<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ACK3</accession>
    <name>A0A1Y2ACK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_475096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000142">
        <property type="protein sequence ID" value="ORY20268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ACK3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ACK3"/>
    <dbReference type="InParanoid" id="A0A1Y2ACK3"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="61"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="156"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="160"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY20268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="409" mass="45406" checksum="65F536D599CB7A30" modified="2017-08-30" version="1">MSSSSQPVVPRRPDDGPYFEEDYSVEIMAYMHSMDALTLASAELMDMQPELQWFMRPYLIDFLIEVHQQFRLRPEVLYLAMNIVDRYVSKRVVYKKHYQLVGCAALWIAAKFEDGKDKVPLVRELAEMCCKAYDESAFIQMEGHVLSTIGWTIGHPSAEAWLRVCTTGVQHEESKVSNTARFLMEITLFHREFVGVQSSVVAAGALMLARYICGKPRKPAQRGESAAVRVSQAIDRHFGEKLESVSEIVVRKYAPTYYGRASTVVREWYLSGRRYVYQPEQPITPMSAGIPTPGLAPSGSWSSKRGSWIAASPSAGSLSCASSDAGDEPLTPVTPNYPHGVDPFNMAAKENINPVYGGAAVAKDAVLMMGKHTSAIPMPVYAVQPSRPALHVLPAELAIPNRTMRRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AD53</accession>
    <name>A0A1Y2AD53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_475009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000134">
        <property type="protein sequence ID" value="ORY20478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AD53"/>
    <dbReference type="InParanoid" id="A0A1Y2AD53"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY20478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="262" mass="29442" checksum="A45707030565124E" modified="2017-08-30" version="1">MVNADKTRNFPASAQDKHYLVIIDNMMNLDMMYEATKLTGDPKYAKIATHQAEKSSDTHVRKDGTTYHVVNFDPKTGKALDFMTHQGYSDESAWSRGQAWGIYGYAQCALRTGRDDFRDTSRRLADVFLSLLPDSGVPEWDFRAPKPCPYDASAGTIAARGLQMLYQLLLPSDKSAAEEYLVRANKLVEDILRECGTPAATLDKDGKVNWGEGSWETLLQHSTINGNEKATRRLLDHGLVYADYYLMEFGNEAIKIERAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADF8</accession>
    <name>A0A1Y2ADF8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_502599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000140">
        <property type="protein sequence ID" value="ORY20307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADF8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADF8"/>
    <dbReference type="InParanoid" id="A0A1Y2ADF8"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="336" mass="36329" checksum="87CD04C3ED5A86A7" modified="2017-08-30" version="1">MWTSSLGLTENITLPGLSPLFPNITCSPSGDICHLTTGEAEINAACSASALVLATKEFDLTKTYFMIAGIAGVNPFTGTLGGVAIARYAVQVALGYEIDARQMPANWSTGYFLFDTEAPGQAATQIYGTELFELNTNLRDAVTAYTSGVQLNDSATAQTYRAKYDYAPANQPPSIFYGDVATSDVWFTGSILDEAFGNITLLWTNNTGDYSMTAEEDNASLEALLRGALAGLVDLSRVILIRTASDFDRPPPGLDSLENLLADAGGFTPSIENIYIAGKPIVEGIVNDWDSTFAAGIPPQDGWLYNSDDLHTLVSERKREVREYQQVAKRAARMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADW7</accession>
    <name>A0A1Y2ADW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_554918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000127">
        <property type="protein sequence ID" value="ORY20712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ADW7"/>
    <dbReference type="InParanoid" id="A0A1Y2ADW7"/>
    <dbReference type="OrthoDB" id="2575524at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ARID" evidence="4">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1383"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY20712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1525" mass="165629" checksum="24500849A9DBA4D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEJ3</accession>
    <name>A0A1Y2AEJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_554336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000120">
        <property type="protein sequence ID" value="ORY20998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEJ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEJ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AEJ3"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000035">
        <property type="entry name" value="Probable fatty alcohol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
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    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY20998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="339" mass="37898" checksum="F4227FB52AD92815" modified="2017-08-30" version="1">MSAVPTISLKDFDARKEEITQQLMDASINVGFFTLYDHGIPSEDIQAAFDLSREFFALPDEVKAKTPLDGKNAGWERGTQVRPSTGTADQKESIQLQFARMEGLWPSDEDIAGFRTRAEKFMHQVQTLSIKVMECFAVGLGLPIDTFTEGTVDPGAGDSQSVLRLLHYHSTEGKSFGPNFWRAGAHADFDVLTMLFQRDGEGGLEVCPGRKVVGDFGMGQTWLPVEARQDRIVCNIGDQLMRWSDDRLKSTYHRVRLPEGTESRGPRYSIAFFNQARTNTTIQGPQKKYPEITGGQFIADALARNRMQSAEIARQAAQQPEDKIAREIHFVPQHLQISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF72</accession>
    <name>A0A1Y2AF72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_591671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF72"/>
    <dbReference type="InParanoid" id="A0A1Y2AF72"/>
    <dbReference type="OrthoDB" id="2564476at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10361" checksum="271390981B96EB9E" modified="2017-08-30" version="1">MPVKRSASEESSDLNTNTSVTPSPSKKPKTSPKSPKSKYTEDEERRFLETINRIVKNSLWQEAKSDPILSKRGANGMQAHWLALYKKLSKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGP0</accession>
    <name>A0A1Y2AGP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_601282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGP0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGP0"/>
    <dbReference type="InParanoid" id="A0A1Y2AGP0"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="389" mass="42825" checksum="EDD0B35E1FDBA2C0" modified="2017-08-30" version="1">MNEDDLLKRFAALRAPTLSPSDPRASTEAASKRAEEEDDELERIADGRGPSVQTVARAQGEEVEDEDKAMQRRLALLRGEEMPLNEDELELGDDEVEAYIASLSSTTFPAPSMAQEAHTDDDKDDLRDEARSALNEAQPFLPSPPQDPSTLDDIENDGYDEEETEEDILRRTLDTVRLEGGSRKKGEKGQEEENELDILRKALEEAEQEVLVPPQPQHPTRADKSIPDAVKDGGDSSLKEDKSEATMDQFPEIPIDLPRSEGEEEADDDDETKRLMDRLLGLSGPTTISLPKVPTSTPGDSHSKVTTTPGDSAKKEVGKGYGLHGWNDERDDDLDSWCCICNKDATLVCLGCDGDNYCNECWAEGHGPGGEVGHRTKRLVWGRKRALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHJ4</accession>
    <name>A0A1Y2AHJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_591430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000100">
        <property type="protein sequence ID" value="ORY21976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHJ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AHJ4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="295" mass="31822" checksum="12E382BA552AABDC" modified="2017-08-30" version="1">MSDTEADIRLRKSILFYEFAKRELDALETAQNPVPTIVVTDTLNPVPTIDAMDVDVEMDPVQTSVATEMTEEEMSRRTIAAHALLSFPRGSAQTAGETSGDGDKQARSDKEISEESASDKEILEENDTVEGRSELIRTMREIDWAKELRELNEALEDGESPAVSRRIGDFHQWYTSLLGVDLGTQNPVQEGTTTEVGEDKSAEKSSHHTNVSFSDLLIAVESVESIYTALTAYFRGQPSAGSGSMAGSQAVSQEASESQTPQSPSTNLQIPAGTSTQSGSAPTTKVAEESSIDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHX0</accession>
    <name>A0A1Y2AHX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_552121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHX0"/>
    <dbReference type="InParanoid" id="A0A1Y2AHX0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="100" mass="10730" checksum="FFC8A20F3F21692D" modified="2017-08-30" version="1">MTHSPAPARPICEIFVTSFVACQGSQSSAAQCGGDDTTDRQGHTLSTPQAPRPASRMRLSASDDLVPVHRKAGGGSQYELCVCVRQCDVKLHVRYAQTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI90</accession>
    <name>A0A1Y2AI90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_552694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000102">
        <property type="protein sequence ID" value="ORY21907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI90"/>
    <dbReference type="STRING" id="71784.A0A1Y2AI90"/>
    <dbReference type="InParanoid" id="A0A1Y2AI90"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY21907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="457" mass="50976" checksum="9EE4A84A32BA8544" modified="2017-08-30" version="1">MAYLGRPSTGDSPFAIGDKAMRDTSSPQPPSQRNPQPRRSPNPGSFMQTPSPYGSVSDEARRRYEERYAKKKAEDEAKLRAETGGGGGGGGSGSSAPPGGYPQQQQQHAPPPQQYAPPPPPQQYNAPPRNQFSPQPGPPPQSFGHSPPLQQQGYQQQYQQQQPPSQGHRPPSGYGSPPPQQYHQPQQQQQQPPPPIQQRWSSGGPPPQNHGGQPQWSNSAVPPPHQSWSKPQSPPPPPPPVQVQQPPDDELRRLFAQFDSRRTGQLDSFDLQRLLAKDATMEAREDCVKMLMNIFDTDRSGAINFQEFEGLYRYIKDWHGIFLRFDRDNSGTIDRKELHQALLGFGFSLPSEMVRKLEKRFAPPPAPGQTRSSGVSFDRFLMACVTVKHFTEGFRRADVNGTGRLTLDYNQFVSLFSPPNPPFLVETPTDIYISREREREKAEMLIMNVDGISIGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIG6</accession>
    <name>A0A1Y2AIG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_551697</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIG6"/>
    <dbReference type="FunCoup" id="A0A1Y2AIG6">
        <property type="interactions" value="657"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AIG6"/>
    <dbReference type="InParanoid" id="A0A1Y2AIG6"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="524"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1172"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="178"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="427"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="686"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1174"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY22381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1221" mass="135332" checksum="B98718A145C915BF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIP5</accession>
    <name>A0A1Y2AIP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_551653</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIP5"/>
    <dbReference type="FunCoup" id="A0A1Y2AIP5">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AIP5"/>
    <dbReference type="InParanoid" id="A0A1Y2AIP5"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="131"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="459"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY22449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="692" mass="76846" checksum="21E2CBDB042EBC0D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKS1</accession>
    <name>A0A1Y2AKS1_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">BCR39DRAFT_550565</name>
    </gene>
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        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Naematelia</taxon>
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    </organism>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000086">
        <property type="protein sequence ID" value="ORY22900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2AKS1"/>
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    <dbReference type="OrthoDB" id="5353557at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:magnesium ion homeostasis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Unplaced genomic scaffold supercont1.12, whole genome shotgun sequence"/>
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        <property type="match status" value="2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
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        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
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            <end position="32"/>
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        </location>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="715" mass="76391" checksum="B7373157B912F4AE" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL09</accession>
    <name>A0A1Y2AL09_9TREE</name>
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        <submittedName>
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    </protein>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="44"/>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="340" mass="37119" checksum="F99876D0CFDD3749" modified="2017-08-30" version="1">MYIRPPPVHDPPPASDPAQCRLLGPTALVVQALMGVIVLCSLVLKRHFENPKRPWKQFVMDVGKQLVGQGVVHALNVLISDLVAHHASNNPCSLYFLNVLIDTTIGVGIFYVALKAFTWFLTKPLGLKGFVSGEYGNPPEMRYWWKQLLPYLLSLIAMKLLVLLPLILPRISTALLRFSYAVLGFLSPNAQVVVVMAIFPLIMNVIQFCIVDQIVKAEKPTDYARLSEGQEDQNPIKGTSGSPLTPNTPLRIATPDGYGSTGASPRGGSPARYAVWENLTLPDFARSGAPSPDTIIRDDLSTSRTTDESQREARRSLSPPARRGALDNQDTGLGLTGING</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALJ5</accession>
    <name>A0A1Y2ALJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">U4/U6.U5 tri-snRNP-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_549306</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="12">
        <location>
            <begin position="97"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="219"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY23438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="63782" checksum="51ECDDC080390CDB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALV2</accession>
    <name>A0A1Y2ALV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rds1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_348282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALV2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALV2"/>
    <dbReference type="InParanoid" id="A0A1Y2ALV2"/>
    <dbReference type="OrthoDB" id="2098436at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012282318" evidence="1">
        <location>
            <begin position="19"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="362" mass="39591" checksum="8BC4369EB52CF5F5" modified="2017-08-30" version="1">MLSTSLLPVLALIGGVLAAPAPIPSGGVGVRSNDTPPVYHTMSEFDYQSLSLGLYQEWIELDLFNYGVERFSAEEFAAAGLGADDVSLIQFMANQEVGHATLLSNIVSAYGRPAALQCKYHYDFETVRDFVNFCQRLTRWGESGVYGFLPHLDSRPSAQLLLQSITTEARQQMIFRQFSGAFPMPVYFETGISQSMGWSLLSRYISSCPANNTRIEWPIFPWLSVTNEPSLLVDGYLANITHNRTSLSEPGRTVTFAYDAPGKSTGPDNSYNTSVGGLVNSTVPKFAAWISQLNVTYTPLTITGNGTASTIQPGGYVFNNTNDGIVNGTMFIGLTDTDLYVTPYNLSLINDHILAFGLYQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM84</accession>
    <name>A0A1Y2AM84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_550185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM84"/>
    <dbReference type="InParanoid" id="A0A1Y2AM84"/>
    <dbReference type="OrthoDB" id="2596262at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="118" mass="11974" checksum="2DE2A3E2A1AE4D8B" modified="2017-08-30" version="1">MSSLTTSKPKLLDAQQVPAQATSIVNASKSGSGRGSITSVNATDAPPIAIASRGQGQGAGRPINAANAMRARGLMVPPHAVTPGNTPNSLDTIRRRIASTVNGTARDGQGNKIAPSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMA1</accession>
    <name>A0A1Y2AMA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_507752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMA1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMA1"/>
    <dbReference type="InParanoid" id="A0A1Y2AMA1"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="75953" checksum="8DA140F17B8572F4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMJ0</accession>
    <name>A0A1Y2AMJ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_549297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMJ0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMJ0"/>
    <dbReference type="InParanoid" id="A0A1Y2AMJ0"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY23437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="519" mass="56488" checksum="8729336F98FD8C1A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APJ8</accession>
    <name>A0A1Y2APJ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_600518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APJ8"/>
    <dbReference type="STRING" id="71784.A0A1Y2APJ8"/>
    <dbReference type="InParanoid" id="A0A1Y2APJ8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="47"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="339" mass="38411" checksum="1CED0191D64CF791" modified="2017-08-30" version="1">MPTSFEGLDYERHLFKSVVNNESDGCFADVYFPKVSNPSQEPHPIALYYHGGGFTLGDSMHIFIGQFRYLLDRGFCVVSVEYRLAPHYRFRHQREDWVDGYRWTIEKLPKLVQARVDTSRIFVFGGSAGGTASLFLGLDAVKAALPPPRAILAVYPALDFDKPGLLPTKHYDYDKIDELINSLSLERQDALRELIRGPSSTSFDFKASLSGNANSPRWLWYQLAQEYSFLVSCYLEEPGAPFSRSNFFIDLVGPQYPPTVLIKALDDTLLDATQTSDAYERLKQLNVDVKLIEAHDMKHGDAEGENDMKEHPAREAGFWDGVFDVALDWCIERTASRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ57</accession>
    <name>A0A1Y2AQ57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane protein S linking to the trans Golgi network-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_548017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ57"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQ57"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ57"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="242" mass="26832" checksum="C835E920A0CBDBF4" modified="2017-08-30" version="1">MRVQGWDPVMIICQIISIQSLHYLALSLLLPPLLTTFTHPSTLQYSGGPATVSHILDWRELASRPTISSSAFQLPDFSLDSAAEGWRKLRGAWAGGKQVGVVEDDQGGIGTGEKAHVGVEDELEALWDFGVDDARGWVIGAAWLVASGFDILPLYYLVRRPTHILDFSLTLTFNHLILTTYYAKSFPTSLFFWVVQALGALLMIVVAEQLCVKREMQTDLDIAWNPSIESVESGEVIELNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQN6</accession>
    <name>A0A1Y2AQN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Frag1/DRAM/Sfk1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_507313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQN6"/>
    <dbReference type="FunCoup" id="A0A1Y2AQN6">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQN6"/>
    <dbReference type="InParanoid" id="A0A1Y2AQN6"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="325" mass="36608" checksum="6156616C952A4F30" modified="2017-08-30" version="1">MARLPLYLNTRTVSSHLFFGPYIFLPLIAGCVWLAEILALLATWVKDGKPKYRSDEASVVFISDVGGMHKLLFIIMSSVTVGFYISSLFAERWLRHVDRLPVDLRLREKVFDWMAIVFGIIGSAALVLLSVFDTFNHSGIHWSMTLVFIVCVALSAIFQSAEVWSLHKDHPDRAHLLRNAIIKLLVILLAIVSAIGFGATYAVCGGNSTATRGHSAQTCNRITSAAAALEWTVAFILVFYFFTLVADLWPAGKSSERYMRRLAKWQEKNGEGDDFTGRRAFDQYPERWQGRADEMRQTMWERNTGIERQNRDSLASGAPLNRPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARW7</accession>
    <name>A0A1Y2ARW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_546357</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARW7"/>
    <dbReference type="FunCoup" id="A0A1Y2ARW7">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARW7"/>
    <dbReference type="InParanoid" id="A0A1Y2ARW7"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="426" mass="47934" checksum="408AF88D03F11560" modified="2017-08-30" version="1">MTSRPLYKKRAWSDEHLLISLAVVVRLVTYVLLQLLSRLPAFDTSHRFLSSAKPSATLRWDAIHFASTAVDGYQYEQQLVWQPGWIAAIRAAGEIVRFVRGGNQLEVDDVVLGGEIIANAAFVGATVALYKLSNQLFNPTFARTTALLYILQPSQSVMSSVYTEPLYALFSFVGFDLALRRKWIRASLCLACATSLRATGIFSAGLTGWMILFERKHSSFAGILRKFVLAGMTTSLIVLPFSLFQAYAYHSFCLSPVTDRPWCTSHLPMAYSFVQAEYWNVGLFKYWISAQIPNLLVAAPVLLISLMATYTYMRPLLQFDSGETSRSIWPAEARNRALPFHIHHLALTLLLIFSSHTQIALRVSSGDPVIWWGLSEMAFKWPNPKRDEAVNSQGRAMSFWGKIWVWWVVLWGGVGIVLWAGHYPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS13</accession>
    <name>A0A1Y2AS13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_309113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS13"/>
    <dbReference type="InParanoid" id="A0A1Y2AS13"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1445"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
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                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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        </source>
    </evidence>
    <sequence length="485" mass="54400" checksum="A078EE8D699EA8AE" modified="2017-08-30" version="1">MFHSRIHIDYGDLVILYFSSQTQEPVIITSGGVFHNKYGRYPHDELVGQKYGSKIHSPAPNPGFVFALRPTPELWTLSLPHRTQILYMPDIAYITMRLGVRVGGSVIEAGTGSGSMTHALSRSVGKRGRVQSYEYHRVRWEKAKVEFEEHGLDNVILQHRNVCKDGFGDDVSGVEAVFLDLPAPWEAIPHAVKTLRPDMITKICCFSPCLEQVLKTVSTLRSEGFMDISTEEVLIRKYELVQPLPPSSNAFKTIDEIVKDLQDHEVRKESRRVIQMRTARQKVALAKQTEALSSTSAAPGDMSSVDITVPTEMTETGAKRSAEADDGEGQHESKRPKLDDPLTTTNESIGLSPVPPPAVLETTDGAPQQTKRSRREPVDPINTITYPKPPRHEITENLPTSTILTRPYPEMRGHTSYLTFASYYPASIRDLIVEPRPQAQRVGELLEEDKARPREQSQETEYGDVLVEETLGKMSEEDLWKLQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATK8</accession>
    <name>A0A1Y2ATK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_282794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATK8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATK8"/>
    <dbReference type="InParanoid" id="A0A1Y2ATK8"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013276963" description="Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="21343" checksum="321DB619D33B7175" modified="2017-08-30" version="1">MLLNSIAAVAFVAGAALVDAAINTPPALVACQPAQLTWTASTPPYIIDIIPGGDVSGAIIEEISSGTAALQITWTVDLAPGRNISFRETDGAGANFYSSPVVIQQGGDSSCLNASASAEVASAASSSPSGATSAESTSTVTATTSGSVSSAASRASSASSASSASSASGTSSSRTPTSTGTSTGSSSGSSTSAASTSSTGAGFVSAATQAPALLFAGAGVIAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATM9</accession>
    <name>A0A1Y2ATM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_544062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATM9"/>
    <dbReference type="InParanoid" id="A0A1Y2ATM9"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="550" mass="60800" checksum="E29B176A13437B54" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATN9</accession>
    <name>A0A1Y2ATN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_542614</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATN9"/>
    <dbReference type="FunCoup" id="A0A1Y2ATN9">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATN9"/>
    <dbReference type="InParanoid" id="A0A1Y2ATN9"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="186"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="314"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY25929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="459" mass="50838" checksum="4A2F4261C0E1EE47" modified="2017-08-30" version="1">MSQPLASMMQGMSLNAPSSPSAKHNPQPGQNRLPAVMKKYMHPGLTRPPNTGLLAHGTESQRGPLLKLAGINTNPQPSHPGSKHQPTSPPGKHKYSLSQHTAHGIHGPAHSTTSRALASSINPHQQVHRTNSVAAGPKGDAGIGKYDGGLEADEAKKESVHGESAKILEMDSGSSSGTIPLSLPAFHIGRPLGKGKFGRVYLARTKAAPHFIVALKCLHKQEIISGRVEKQVRREIEIQQNLRHPNILRLYGYFHDEKRIFLVLEFAVKGELYKQLSKVGRFDEKRSSRYIYQMADALAYLHKKHVMHRDIKPENILIGLKGELKIADFGWSVHAPSNRRHTMCGTLDYLPPEMILGKEHTAQVDLWALGVLTYEFICGNPPFEDMAGTQATYKRIQNVDLRIPSHVSPEAADLVRKLLKFEPEERLPLAEVMVHPWILKYQRKKTSTSGQGVGSTRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU98</accession>
    <name>A0A1Y2AU98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_560675</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU98"/>
    <dbReference type="FunCoup" id="A0A1Y2AU98">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AU98"/>
    <dbReference type="InParanoid" id="A0A1Y2AU98"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY26131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="285" mass="32358" checksum="A6B791D574B3349E" modified="2017-08-30" version="1">MVTIRHSGVNKDGIHEVWADNLESEFAALRNAIDQYPYVSMDTEFPGIVARPIGAFKTGADYHFQTMRCNVDMLKIIQLGITLCDEEGHSPEISTWQFNFQFNLGEDMYAPDSIELLKNSGIDFKRCEEDGIDVEYFGELLVTSGLVLFDNVKWVSFHSGYDFGYLLKILTCAPLPANENDFFSLLAIWFPCIYDIKHIVRSVKTLRGGLQEIAESLGITRIGPQHQAGSDSLLTAAVFFRIRSNYFNNDLEDDYYKNYLYGFSSGRHGKVSPTTFNSVITERPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUC2</accession>
    <name>A0A1Y2AUC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_271553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUC2"/>
    <dbReference type="InParanoid" id="A0A1Y2AUC2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="132" mass="15213" checksum="913F59AC04DEF781" modified="2017-08-30" version="1">MSHLSSLLCLRHRAARVDLFPFPRLLFLISLLCSLILSLTRFEKKTFFGSHEYAAWETGNSMAQVTKRRGKGKKERAGERERKKERRGGRVSRDKKTNMVIISLDTLEFQARTLGRSSFVILGHEEEGLVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUW6</accession>
    <name>A0A1Y2AUW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_541385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUW6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUW6"/>
    <dbReference type="InParanoid" id="A0A1Y2AUW6"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="453" mass="49075" checksum="A4B587BEFE23742E" modified="2017-08-30" version="1">MPAPVRTAAQWAQFGRDHVSHGLGRMQDLVVVKGEGLDIYTSDGQKLLDFTAGIGVTNLGHCHPAVTAAVQNQVGSLVHMQCSIMFHAPYLQLIERLLPVMPHPSLDQFFFWNSGSEAIEAALKLARKATGRPNVVVFQGAYHGRTYGSGALTRSKPIYTQSTGPLMPGVYTTAYPYWHSLGVPPSTSEEEIVRLAKHQLDMLFRQQVATKDVAAIFIEPVQGEGGYVPCPAPFMNHLRELCDKHGVLLVIDEVQTGFFRTGSYFSVNHIKGFRPDIMIYAKGIANGFPLSGIVSNKEIMATLDVGSLGGTYAGNAVACAAGVAVQDVFASEDIGGNVNARAEQLYNALYALRDSPKTAPLVAQVRGQGLMAAIEFRMPNDPLTHEGLDKGTHIPSNIGKRVQEFCLSKGLVVLTTSCFDTIRFIPALVVSEEQMDKAMKIFTEAVQNVANEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUZ5</accession>
    <name>A0A1Y2AUZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_541183</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUZ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUZ5"/>
    <dbReference type="InParanoid" id="A0A1Y2AUZ5"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY26306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="770" mass="83116" checksum="FC47946613784EFB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV91</accession>
    <name>A0A1Y2AV91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_269743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV91"/>
    <dbReference type="FunCoup" id="A0A1Y2AV91">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AV91"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="228" mass="25345" checksum="281F0F7C3BFD96BE" modified="2017-08-30" version="1">MLHTSPSAKRIHLTRHAQAEHNVANDYSIPDAPLTELGKTQARELHNMSKDSVQRTADLLVCSPLRRPMETMLLGYPSLKSRLDREGKPVILLDILQEVGPYPCDTPTTPISALKAANGGIFSSLDFSTLSPEYASKRGIYHPDRASERARQARRWLRDRPEAEIVVVAHGDILRYIADGQNSSRPWDNAETKVFTFHSSSDDNAGLVEIAHHAKPKDATDEPTSSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVZ4</accession>
    <name>A0A1Y2AVZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_540125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVZ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AVZ4"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013299492" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43413" checksum="111696F4AF46BDE6" modified="2017-08-30" version="1">MLEILLAFIPLCSLLTQAAPLHGRSTPNPVVKTATLYGPISETEPVYLDRDSCGSTKWGDRVLFVCRDTEVYKDLANRSEGVTAFFSSSASYIDINSDGSLSFVPFTPEPGTPDSESHFNYSLPAYGANNNKAFYPTQPDECDAETGSCDNNSTRWVIWPDSPPLVSSEGADGTIKAYSWIKKAYITDSLGVIIENPAISLYRLDYSPSIQGTGDVLPAVTLVNEEFFHENQWTYGDFGNIVIDDTAYLFAATGNGTTSLAKVPIGSEEDVSAYQYFVSGAWTSTMPSINDPNAIIIATSGGQGTFYFSQPWNSYVWIGQAVNDGSLTFQITTAPAIEGPWTVPKTFFSVASSPGLVYSVQAHPAFLSDPSINSVWVSYTVAINNYGYDTILYKFDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWK5</accession>
    <name>A0A1Y2AWK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">succinate-semialdehyde dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_539845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWK5"/>
    <dbReference type="FunCoup" id="A0A1Y2AWK5">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWK5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWK5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF10">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE (NADP+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="122"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="594" mass="64247" checksum="5375389919BC2903" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWX5</accession>
    <name>A0A1Y2AWX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_506377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWX5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWX5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="353" mass="39041" checksum="3A373F3EE524158F" modified="2017-08-30" version="1">MEPHPDLGPMHPDRKRQMHMSNSDFDVSVWRREVATVRALGGESEQRSRTPPFWSPSSPSGSWQPSTSSSAYSGLPSIHGQPSLSSETRLPPRFRSRRQGFQPGTMTTRGRLAGGHNESNNRGQQSSGPPIVGTSNRLSGTSYENANGFYDPQPSFLEDNRSYPRRRTGYPPHEPFQAHPQMGQSQHQYRDESRYLDDSLLNDYDPRYEGSDSDNGGSSGYPDEDGCWSDQVIDGEEGNGYGAIYIGGEDYGYYNDQDVYGVYRGEDDHDNDGEGDTWDQETMQMLHHSAYPAHSIAGPAPVMGSTPPFPWPSQSFDPGVNPQSFGDSRSGLPRGFSGRVIRGGGAYRSSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWZ5</accession>
    <name>A0A1Y2AWZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BCR39DRAFT_539569</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWZ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWZ5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWZ5"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="795"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="26">
        <location>
            <begin position="64"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="25">
        <location>
            <begin position="209"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ORY26964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1074" mass="112205" checksum="273711FDA4205B3E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXY7</accession>
    <name>A0A1Y2AXY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BCR39DRAFT_589142</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXY7"/>
    <dbReference type="InParanoid" id="A0A1Y2AXY7"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
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    </dbReference>
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    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
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            <begin position="434"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="546"/>
            <end position="567"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="620"/>
            <end position="636"/>
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            <end position="767"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORY27431.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1389" mass="150729" checksum="F68AD0756795799B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY14</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">BCR39DRAFT_226268</name>
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        <name type="scientific">Naematelia encephala</name>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">68-887.2</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
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        <property type="entry name" value="Est1-like_N"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TPR-like"/>
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        <location>
            <begin position="151"/>
            <end position="299"/>
        </location>
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        <location>
            <begin position="327"/>
            <end position="606"/>
        </location>
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        <location>
            <begin position="862"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="106927" checksum="87ED55411D11FE90" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYS8</accession>
    <name>A0A1Y2AYS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
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        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="7" type="ORF">BCR39DRAFT_589082</name>
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        <name type="scientific">Naematelia encephala</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYS8"/>
    <dbReference type="FunCoup" id="A0A1Y2AYS8">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYS8"/>
    <dbReference type="InParanoid" id="A0A1Y2AYS8"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="202"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="344" mass="36630" checksum="2613833ABACAF131" modified="2017-08-30" version="1">MSSPRPNALIFGLGGIGGIYAAILALSGKCDVHVVARSNYAAVKERGLRLVSGKFGNHDSIKFAGVFRDCAEAAASGKTFDYVLCANKALLDAKPSLSDQLSPLISAPTSIVLLQNGVGGEAPLHASFPQNTIISAVVWTGGKVLPEQDGVAGVEQFNREGLTIGVDYRSDEPSERAEEDAKLERLVEVLKAGGGDCTVTKDIQSERWIKVIWNCCWNALTTVTRGRTGPLFDSSPYALPLCHTVMDEVTAVARAKGLSIPEGTTEKLIKQCTDVAGLGLPSSMMVDCFAGRPMEVESILGTPVREGDRLGVKVPTLLTLYTIVKALDYGNSHPDTQIDGQRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ92</accession>
    <name>A0A1Y2AZ92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_536618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ92"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ92"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ92"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="614" mass="69036" checksum="220F1360162A0EA4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZD6</accession>
    <name>A0A1Y2AZD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_537772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZD6"/>
    <dbReference type="FunCoup" id="A0A1Y2AZD6">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZD6"/>
    <dbReference type="InParanoid" id="A0A1Y2AZD6"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="244" mass="26611" checksum="2113C21AD72D86A7" modified="2017-08-30" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAMEAIKLGSTTVGITTPEGTVLAVEKRVPSPLLESSSIEKIMEIDAHIGCAMSGLTADARTMVDHARVTSQMHAFTYDESIGVESCTQAVCDLALRFGESVEDDDALMSRPFGVALLIAGIDEKGPQLYHTDPSGTFVRYDAKAIGSGSDAAQQSLQDAFHKQMTLVEAHTLALKVLKQVMEEKLDENNVQLAQVTREHGFEILGETELKQVIEGIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZM2</accession>
    <name>A0A1Y2AZM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_217196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZM2"/>
    <dbReference type="FunCoup" id="A0A1Y2AZM2">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AZM2"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="513" mass="56909" checksum="8C3A3A7E99F49082" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0B1</accession>
    <name>A0A1Y2B0B1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_535252</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0B1"/>
    <dbReference type="FunCoup" id="A0A1Y2B0B1">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0B1"/>
    <dbReference type="InParanoid" id="A0A1Y2B0B1"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="461"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY28278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="963" mass="105860" checksum="1FF48F6DB60713C2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0B5</accession>
    <name>A0A1Y2B0B5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_205392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0B5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0B5"/>
    <dbReference type="InParanoid" id="A0A1Y2B0B5"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="164"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="297" mass="32012" checksum="5ACB4ED039F8DA34" modified="2017-08-30" version="1">MPSPLSPSSSQEIIAISPPLPPPSTSKASSSKISLDTLDGGTTLPKPALWDPPVELRGKMVRAVRAYDERVDIQSGKQKAGKGETERERKRAVGAGRARQTEIMMNTLGKGVNPITNSDLYSRSDHFVSCATGHQQSNRGGGSSGATTYWEVRNAKMAEQAREKTSELFRGCVFYINGSTGPRLSNLQLQHIITSNGGRFTATQNGSNTHIIANGGLSGSKTQKHINGQGGRGASRRAKVVRVEWVLDSLERGIKLSEARYGMIKDPTQNSLLSAWGSNSNDENHVKEQSPIQGSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0C3</accession>
    <name>A0A1Y2B0C3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_535890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0C3"/>
    <dbReference type="InParanoid" id="A0A1Y2B0C3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="189" mass="20917" checksum="28AE0B63AFFC8A0D" modified="2017-08-30" version="1">MDSINPLPIHPLVWKATVRESLIRVGLSLWLREVDGVARRGVEPPRSDAAWNQWYLDYETARAAICGPDVLKGSFAAVVESNEFFALPDLEPIPSVYQVVEKLVQDVYESFERQQASSQTIFVPKRPLEAPPSSSPHRHNTVSISAFVNDRHPPSLDLPATLGPSSSAVDVTDLTLGFAGVRLSDYTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0E2</accession>
    <name>A0A1Y2B0E2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative MFS maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_496604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0E2"/>
    <dbReference type="InParanoid" id="A0A1Y2B0E2"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="62"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="550" mass="61173" checksum="3EB1397A4C431237" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0V6</accession>
    <name>A0A1Y2B0V6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_534816</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0V6"/>
    <dbReference type="FunCoup" id="A0A1Y2B0V6">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0V6"/>
    <dbReference type="InParanoid" id="A0A1Y2B0V6"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="16">
        <location>
            <begin position="553"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="248"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="507"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY28469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="778" mass="75436" checksum="2A4F0CA1AB7721FC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Z1</accession>
    <name>A0A1Y2B0Z1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_209581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Z1"/>
    <dbReference type="FunCoup" id="A0A1Y2B0Z1">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0Z1"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Z1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="205"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="351" mass="39297" checksum="5A4722C597B67E69" modified="2017-08-30" version="1">MTILQSLPIIDPTSYLPHTHLLPSVSLSTSNNRPSRSETANAIHRACRDVGFFYLRVDSFLSPEECNEVVDSGREFFKRPQEEKELIRLEESDGVRGYQRLHQNITKGKADHHEALDLYAPWPSSSSPPTASESMTDSSESPKTTLAPLRGPNQYPSNPASMRHTLERWTEKMKILGEAVMHAMADGLGLDDKEWKDLWGLVNDSFWVMRVIGYPPLPPGAEGISCGEHKDYGCLTFLLADPIPSSLQVLSTSSTWLSADPLPGCLVVNIGEMWSIWSRGLYPATLHRVIHTSPTYRVSVPFFFEPNYHARVKGLEGARRKCLEEGREEVDGGEVMYGDFLLGKVSGNFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B127</accession>
    <name>A0A1Y2B127_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_535096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B127"/>
    <dbReference type="STRING" id="71784.A0A1Y2B127"/>
    <dbReference type="InParanoid" id="A0A1Y2B127"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013231592" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="175"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49262" checksum="7E48841929CCF3F4" modified="2017-08-30" version="1">MMLVLVWLAALLGTRVVFAANTSNTSNSTITGQQICNPDVCVTALRNTAKKIDTYTLAPAKDLALGLSEFGWIAIGFGSQMNGSPMIITWPNSDGTFTLSQRQASGHNAPKVVSSPARKATLLSSSSFSNTSSTAITFTLPITSASTTSANSTKLIWAYGGTNPKSTSTSATIRQHNNMGTMSIDLLAAYSSTSSSSSSSSDSSSAGPSYSVMIAHAVMGGLATLLFFPVGVLIPRIARGFSIKRWWFPAHSVMNGIIGGVLVIAAFGLGVNKFQGGINSAHRKCGVALFILVILQIALGLGSHYYRPSRTIVFSTASGRGPSNFSHVALGLVVLALGWATAWFGIDSEWKVYDGKGLNVGWKVLWGLAVGITSTAYLVGIGILLPRQRNLEAQQRRQRRDQDLELSRAEFLKNGQQEQDSRGQSKDTTGHSRDFEQHVYGQTQIEREREREGWAGNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B220</accession>
    <name>A0A1Y2B220_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_533850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B220"/>
    <dbReference type="STRING" id="71784.A0A1Y2B220"/>
    <dbReference type="InParanoid" id="A0A1Y2B220"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="42619" checksum="CAD052339D3F6D52" modified="2017-08-30" version="1">MSLSSSTLNLKFMQRALARQAPSTPKSTSTSTPISTSTPLILPSSTKQSGSLPPPPATPTPAPNTTIGTATPVGQSSTPQTSGPNTSAALAEEEAARWFLPLPTSSFPSASSSRLVEKDRVRIENSYLPFLETGEGSWGGGGGRMRFGYGGDSKDDEEGEGGEEGDDGDGEERHEQGEGDRRGTGQSQRGKDEGEIRSARRDQARSQTNPRPSARAKVTETNRGVDTTPRQGIPNTPSGAVPNTPSNARTFLRPQGLTEHNVPSIPRSNFKKPDSTTIEPTTTPSRNAGNVKQLSSQVDKNNDDNDNTPRSKGPKKRKLDSLQSQPQPPSNSQKQSPPQAQSQSQPRPQLVDQTTLSPTNPSPATNGGLDDRERELKAAKRREKKARKRAKAAAGGTETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B239</accession>
    <name>A0A1Y2B239_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative iron transport multicopper oxidase FET3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_535645</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B239"/>
    <dbReference type="FunCoup" id="A0A1Y2B239">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B239"/>
    <dbReference type="InParanoid" id="A0A1Y2B239"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012463359" evidence="9">
        <location>
            <begin position="16"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="156"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="401"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY28145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="633" mass="70154" checksum="DACA692D1E0CC378" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3G7</accession>
    <name>A0A1Y2B3G7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_533638</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="13"/>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3G7"/>
    <dbReference type="FunCoup" id="A0A1Y2B3G7">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3G7"/>
    <dbReference type="InParanoid" id="A0A1Y2B3G7"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000037">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="677"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="713"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="765"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY29017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="797" mass="88413" checksum="41C29FFC5ACA94D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B490</accession>
    <name>A0A1Y2B490_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B490"/>
    <dbReference type="InParanoid" id="A0A1Y2B490"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="61" mass="7213" checksum="A531DA6177D65AC3" modified="2017-08-30" version="1">MGLARSIWMISTLVMLVYRMLRKRDLKRCLRNSNDCSSLGGKKWIKHLYQSEEKRDGIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4A1</accession>
    <name>A0A1Y2B4A1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_574881</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4A1"/>
    <dbReference type="FunCoup" id="A0A1Y2B4A1">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4A1"/>
    <dbReference type="InParanoid" id="A0A1Y2B4A1"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ketoreductase" evidence="13">
        <location>
            <begin position="115"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY29556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="44257" checksum="E037D49AF4E59C4F" modified="2017-08-30" version="1">MTEISAVPHPLPALPSSLDIDLIVKVLNKTFFSPFFCAFLPLTFLSQVKSTSHPAFILSCIWTALVFIFSEFFGYRNVLCITNSLIIDALNHLDRIYTNQGSFLFAPPKLDWEEQIVLITGGGTGVGRLLAETLALRNVTVVVLTKSPPLEEIENNNILTYICDVSDCKQVQDTAARVREEVGDPTILVNNAGVIKGKLLLDLTEEDITETFGANTLAHFWILKAFLPTMLRRGAGHVVNISSIMGLVGAAQMSDYCASKAALISLHETLRAELNTRYLTPAIRTTLVLPSHIQTSLFERIQLPPTRFWRFLAPTVSPHTIVKEIIQALDSQESRVIRLPFYSQAARVLGTGAGLVPHWLRDLLQWIANADLSMAAYGPKPDAGERLQAERATGRHEKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4L3</accession>
    <name>A0A1Y2B4L3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_531610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4L3"/>
    <dbReference type="FunCoup" id="A0A1Y2B4L3">
        <property type="interactions" value="681"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4L3"/>
    <dbReference type="InParanoid" id="A0A1Y2B4L3"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="6">
        <location>
            <begin position="135"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="200"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="269"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="329"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="382"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="576"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="635" mass="67715" checksum="7AE073F70B8C567C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4Z2</accession>
    <name>A0A1Y2B4Z2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_530976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4Z2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4Z2"/>
    <dbReference type="InParanoid" id="A0A1Y2B4Z2"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002137">
        <property type="entry name" value="Specific RNA polymerase II transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="556"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="594" mass="64553" checksum="6BFFDE08A8B5DFCF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5F9</accession>
    <name>A0A1Y2B5F9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_494923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5F9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5F9"/>
    <dbReference type="InParanoid" id="A0A1Y2B5F9"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="213"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="558" mass="61389" checksum="A2ECB6B84EA45554" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7K2</accession>
    <name>A0A1Y2B7K2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase I-specific transcription initiation factor RRN6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_587775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7K2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7K2"/>
    <dbReference type="InParanoid" id="A0A1Y2B7K2"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="167"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
        <location>
            <begin position="799"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="937" mass="104627" checksum="27804372BE55E5B9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B865</accession>
    <name>A0A1Y2B865_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_527816</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B865"/>
    <dbReference type="FunCoup" id="A0A1Y2B865">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B865"/>
    <dbReference type="InParanoid" id="A0A1Y2B865"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY31019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="128" mass="14038" checksum="9E13E025CC497959" modified="2017-08-30" version="1">MAAPGQIFYEFYRGSSIGTALTDSLDELITAGDIPPQLAMRVLQQFDKSLTENLQKNVKNKTTVKGHLSTYRLCDDVWTFVVKDPQFKMEGQGHAVEMVTAPKIKIVACKSGDAPDGKKGGGKNQDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8A1</accession>
    <name>A0A1Y2B8A1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_587720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8A1"/>
    <dbReference type="InParanoid" id="A0A1Y2B8A1"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="663" mass="73292" checksum="5C0B8A835304CD68" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8F5</accession>
    <name>A0A1Y2B8F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhamnolipids biosynthesis 3-oxoacyl-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_527959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8F5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8F5"/>
    <dbReference type="InParanoid" id="A0A1Y2B8F5"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="34526" checksum="CF8F288A5EED1733" modified="2017-08-30" version="1">MSNISFKIDDIFSVAGQIVVVTGGGTGLGKAITAGFATNGAKVYITGRRGEVLQATADEINGQVEGGGLVIPIQGDVATKEGVLKIVDAIKDKEEKIDTLVNCAGVMRGWKSPTKKHNDPDSVESMLLDVDDDDFNYSNSSLFPHRPSFRLLWNNTDPLLPLVNLNGVYFMTVSLVPLLRKAESPNVVVIASIAGLANQRTMGSLTYGASKAATIHCASLLAGRLHPMKIRVNTICPGIFPSEMTGVKTDTSHKYNLGDAADKAAVRSTAQRPGAPQEIVGPVLLLASKGGMYMNNALLTVDGGRLMMAGINDGIRMPDETFPEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8S3</accession>
    <name>A0A1Y2B8S3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_493966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8S3"/>
    <dbReference type="FunCoup" id="A0A1Y2B8S3">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2B8S3"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="393" mass="41321" checksum="7F08F47244060F47" modified="2017-08-30" version="1">MSDDTSSWKVTAVVLFYMAVALIMVMTNKWVLTTTSLPLTFLFLQLSISVICLCLLSLAPSSSRFHFRPPRWSLSSIISMAPVCTANVVGLVFNILCLQLVDASYFQVARGLTLPFTVVLSALYFSDKPSLPTILSCGLVTWGFTYSFFSISSIVTNTGILATTGAVPDTAAAAGGGGGGGGEAPMLGMIFGVGSGALVAIHAVLVKGALKTLDGRTMDLAWWSNLLSAIALLPAIVISGEIRGIARLIQGTQGSLNAFITGSGITGIVGFLICLAGLLSIKVTSPTTHMFSSAVRSVLQTVLGVYLFGDALNANRIVSIFLILLGSTIYTYYKSRANSSPPSRPLTHSPSKEPLLGYSSEKNRENDPEKGLINGTGTGTGLGLNGRRSPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B948</accession>
    <name>A0A1Y2B948_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_526295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B948"/>
    <dbReference type="FunCoup" id="A0A1Y2B948">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B948"/>
    <dbReference type="InParanoid" id="A0A1Y2B948"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY31362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="434" mass="47208" checksum="8A870FA71B8F3A4C" modified="2017-08-30" version="1">MSLFASAFDTGLTSGPSYTTLTAPKSAKAQIKRKRPSYPETQDREDGRVRNVQKNFERVMKRVDGGEVKPKPRKEGTEVMGMARHGKKHNVKPATHNVEQNAIAKPGLGKSVLSPKETSYQSTSSASRERPAPAELPLPHDISKSLPKTSSAEEGLTNLQQGMKAKLEGARFRWINEQLYSTKSTEAVEMMKKDPKIFADYHMTHRALTSAWPQPPLPHLISLLTPLSAGTLVVDLGCGDAGLAKALVPQGKVVLSYDLVGDSGVPTDGQGTGGWVVETDFLEHVPLPGRPGGRSTAAAEEEEEAQPIKKSKKKGKAKASEASEVVDVVVCCLSLMGVNWVGGIYEACRILKQGGVFHIAEVTSRFISTEAFISKIESFGFELEHQEAPSSHFTLFRFKKSASTPHGPARGEAGWHARVKDGEQILRGCVYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9M3</accession>
    <name>A0A1Y2B9M3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_105254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9M3"/>
    <dbReference type="InParanoid" id="A0A1Y2B9M3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="159" mass="17747" checksum="3C7E2810060015AD" modified="2017-08-30" version="1">MSHDRCSKLENRVSTYMSLVDNISKRDKTMESIAPTDTHRKIGDPKRTLPLGSRSPDSIRSFPATQEGDLNEQSLAENSSRRDLGKRRFETLESLTEEPDDRPTKNSKATTSSSTTRKHTLRKASMGSTESVVPPIATQNPEKIGKVRGRSSVRFADKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAS3</accession>
    <name>A0A1Y2BAS3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_524742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAS3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAS3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="110" mass="12841" checksum="77F2AEA50A108802" modified="2017-08-30" version="1">MRSNPSMYRHTKYYRPHSASAPYRPTAYHSSSAKALLSPFYSRSFVRGIRRQSQTEAEGASGNNEKRESETITGWLGWAWMAFICRLSDSVDRPVQRKVPGEKWRRRDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBU0</accession>
    <name>A0A1Y2BBU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_523398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBU0"/>
    <dbReference type="FunCoup" id="A0A1Y2BBU0">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBU0"/>
    <dbReference type="InParanoid" id="A0A1Y2BBU0"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="219" mass="24251" checksum="A10848277DAE55AF" modified="2017-08-30" version="1">MDSRASLPLVPLHLTSLAILSPSNSPLYVHSFTSPQDSLRHYHLSHAAIDVIEERIIMTSTPNKPADSYLGLLFCMEDMAFYGFQTTTKLRMVLSVALVDALIKDADIVAIFRAIHHLLLQTTSNPFLSLPSSFRSHPALSLPSTESTPTPTQTQTQTQTQTQTQTQTQTQTAIHNPPIPINKMFATGPEEIQSDWLRDSERFQRGIEGIGSLLNGIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD87</accession>
    <name>A0A1Y2BD87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_504125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD87"/>
    <dbReference type="InParanoid" id="A0A1Y2BD87"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="228" mass="26951" checksum="3F0B4770E9C052D2" modified="2017-08-30" version="1">MHILQDEVSRVIKEIWACAVLWFGIGPIRSWKRIRCLNKLVERELSIKEKLINTWSTGDCPPVSPGEEESMVHFDDLEDLLQVSRDRDWDWQTDIWALHYSLNDVNMELPVVIKIQWGISITDQDAQKTYDIVSVLCTRTNIKFNEGHHNIEGHQCNEYKYDVWWLIVILHRIWPDLIKSQMNPTYEYMPRWHRRSIEDVARCRDMFQKCQVGVSQGGIGEREIVPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDA7</accession>
    <name>A0A1Y2BDA7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase phosphorylation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_350505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDA7"/>
    <dbReference type="InParanoid" id="A0A1Y2BDA7"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="397" mass="47293" checksum="8A3C0A086021B7AD" modified="2017-08-30" version="1">MHDGPIREGNRGGQGDFRWAAVVDDKHRENYLGHSVQAPQGRWQKNKDIHWYQRDALPLDKAAADRERAEEIKRLKEQEEEALAVALGFAPKKKPVGEEDGGDGTTGTGANGVPVKGEIERLEKEARRREKEEGILLGLEEKEGQAGDGRKVMLGYRGRLGRGWKKGHARLLRRLRREQRALKRVEKEVKREEKERSKGDRRSKREYSENHYDRRRSRDRDDRPSRREDDRYDRHRSRDHENRYDRHKSRDHEDREDRHRSRVHEDRDDRHRSRDHADRHRSREYDDRDHRQERDPRSRRYDNKDDETYQNQRRRHDKTPPVKRERRSMSRTPPPVKREGEREQRSRSRTPPVKRERRSQSPLKRDRVPVVPVVPASVSAGVEPESTSFLIVDESDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDD4</accession>
    <name>A0A1Y2BDD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_521844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDD4"/>
    <dbReference type="InParanoid" id="A0A1Y2BDD4"/>
    <dbReference type="OrthoDB" id="2447764at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="52"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="290" mass="33160" checksum="F7654D7EA95407B6" modified="2017-08-30" version="1">MRRSSRMSSSSASSIEVGTPISSAPATPIRTSTRTKKRPSSQSSSSSESGIYVVDSIIARSIEQVFGDNGVEEYQYLVRWEGYGPKEDTWEMESNLVLGAADIVRRFQSQIHDAGHPFTLLDWRDYSPKRYQVRYGESPYAQTVWQTAVQMRDTMGVTNSALAKAYHKGAYAPRSYKAQQRRLLAILDHSQYRKSKDSKRSEVKRSGLTVYMTRWREGRVTEEGWIFRSQLVSWFGPSGAMTAIQQYHERLADTKKKIAESLNAVQLSQYEEGRLRNIQENQDLMRQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDQ3</accession>
    <name>A0A1Y2BDQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein rhp7 treble clef domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_522058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDQ3"/>
    <dbReference type="FunCoup" id="A0A1Y2BDQ3">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDQ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BDQ3"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="594" mass="64802" checksum="493ACC0411FC716F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDQ6</accession>
    <name>A0A1Y2BDQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rtf2 RING-finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_522353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDQ6"/>
    <dbReference type="FunCoup" id="A0A1Y2BDQ6">
        <property type="interactions" value="671"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BDQ6"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="336" mass="35989" checksum="4B3B702D08EE53AA" modified="2017-08-30" version="1">MGADGGSIPDRRDLVKTKAKAEQTDKALLRELFFLCALSKRPLSRPVVLDPLGKLYNKDAVIEYFIDRSKYGDGDQICGYLKGVKDLMTLNLTPNPSYTPSISSTTADIPSRAPFVCPLSLKEMSGTVPFIALRPCGCVFSDAAIRAVIPNLTKGSAASAMIKDDKPDEAKPVTSGVKEEVACPNCGKPIEPTKSSTILPINPPREVQELLLDNLLASRAAAKSSKKRKATSAIIEATTVSADTEPVKKAARPSSESPVPRHSASPAPGGRATSAVSQNSLVRSVHEKLAEQEQKRLVAQAGMSDAVKAMFKPKGDPGQKRSGMDDFFGRTFTRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF42</accession>
    <name>A0A1Y2BF42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_520163</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF42"/>
    <dbReference type="FunCoup" id="A0A1Y2BF42">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF42"/>
    <dbReference type="InParanoid" id="A0A1Y2BF42"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="19">
        <location>
            <begin position="423"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY33453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="741" mass="83227" checksum="20ECC1BA929565E4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF62</accession>
    <name>A0A1Y2BF62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF62"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF62"/>
    <dbReference type="InParanoid" id="A0A1Y2BF62"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="264" mass="28969" checksum="2952F94E705DF079" modified="2017-08-30" version="1">MGGTVEVCLDSLASAQIAADIVNDVDNRIELCSNLIYGGGLTPSLGLLRQCATVITGRKFMIMIRPRIGSFMYTPSEVETMLSDIDVFKSEPSVKGFVFGCLLEDGRIDVHLTKRLVDACGPFEVTFHRAFDLTPDWEQAIKDVWSIPGITRILTSGHARTAPQGAQQLNHLITWVSAAHERDPGRGRLTILPGSGIGPTTISEIKERTPNLHEVHLTASSAVVLSDTEINRRGEELGFGNEAWAMDGLKLRSVWEVVKDWEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFX0</accession>
    <name>A0A1Y2BFX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_518680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFX0"/>
    <dbReference type="FunCoup" id="A0A1Y2BFX0">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFX0"/>
    <dbReference type="InParanoid" id="A0A1Y2BFX0"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="203"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="831" mass="93388" checksum="C5387FF273CA26E7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFX1</accession>
    <name>A0A1Y2BFX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_265315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFX1"/>
    <dbReference type="FunCoup" id="A0A1Y2BFX1">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFX1"/>
    <dbReference type="InParanoid" id="A0A1Y2BFX1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="49"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="476" mass="53008" checksum="FF6667E5B2C07537" modified="2017-08-30" version="1">MASSAKYTPLDTAHLRSQDPSEETTMQSLIDASEHLAQEALEVMPYAFDECTYQKGYLRQSIWSCLDCGEKGVCYGCSISCHSDHRLVELWTKRHFRCDCATDMNPSSSTSTFTTKRRRCTLNPPEIQPADPNEENRYQHNFSGQFCRCGRSYDPEIETEAMINCIACEDWYHESCLNLASRKPVKEVQEGEDEDEDEEKDVLIPSDSYDGLLCARCAEGCEIAKCCRGKDGWMTIEPKEGEGGGWVVRGRKETKEENIEDSKDKKDINGSEVKSEDPRGAPVGVASSVEIDTAKVELGIKRVAEDTVEDKGVKKIKIEDNSSTAKDVKPTDSQDVKPTDSQDVKAMDSKDVKPTDSKDVKSTELKGAGDIFLADGIRERLKSTLSSAEIASLPFPLVDEEIYEPPRDTDPETLDQVTNRVVGSLPRVQAIEALHGYQNMKEGLKVLLSGRAERGEIVTRDDIEGFFADLKGRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGL9</accession>
    <name>A0A1Y2BGL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_592578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGL9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGL9"/>
    <dbReference type="InParanoid" id="A0A1Y2BGL9"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="72694" checksum="FE75F0CD6D5DA934" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGU1</accession>
    <name>A0A1Y2BGU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_586415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGU1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGU1"/>
    <dbReference type="InParanoid" id="A0A1Y2BGU1"/>
    <dbReference type="OrthoDB" id="2630497at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="292"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="392" mass="44008" checksum="A3F7C5BD7F89D7C6" modified="2017-08-30" version="1">MTTPCSPDTWILLNSFDPYYVPSTQATPTAKLSVIPLSDSLPTTATLVDIGGFEPENPKSPSPPSKKCIIPVTQASFSQDESASPRHLLFPLPLTASESSLKNWQEPEVLSTLIDVTLQRDKVIRTLQDHVEKLEVQVKVLQEESVSKEDLNRTLDKKNTASQNSRSKAGRKKISPLPRVNRFGTGGTTTGLATELEALYPQTTPCSSNVALDLRQDEIISETQRVHWSCAGLDIDTSYTPETYVCPECSFILATAPYSNIAFAQQERCVRPDCILHMHKAPQVRDGDDERFRMERIIGRRELPRADPSSTKKFEYLVKWEDWEINDCTWEPADNIDNLEMHLGEFKEVCDHEDLDYRLPVVLLSEARSAWNETGILLSRTRPYSQGGVGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGV6</accession>
    <name>A0A1Y2BGV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_233998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGV6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGV6"/>
    <dbReference type="InParanoid" id="A0A1Y2BGV6"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF144">
        <property type="entry name" value="METALLOTHIONEIN EXPRESSION ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="899"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="962"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="453"/>
            <end position="507"/>
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    </feature>
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            <begin position="721"/>
            <end position="749"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="768"/>
            <end position="877"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1025"/>
            <end position="1078"/>
        </location>
    </feature>
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            <begin position="13"/>
            <end position="29"/>
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    </feature>
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            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
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            <begin position="455"/>
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            <begin position="497"/>
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            <begin position="788"/>
            <end position="798"/>
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    </feature>
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            <end position="811"/>
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            <end position="850"/>
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            <begin position="1029"/>
            <end position="1039"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1078" mass="115421" checksum="8226BD0BBF595B5D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHE0</accession>
    <name>A0A1Y2BHE0_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Naematelia encephala</name>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="242"/>
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            <end position="427"/>
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            <end position="533"/>
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            <end position="82"/>
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            <begin position="509"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="ORY34201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="549" mass="61464" checksum="B0899A6D118FFE96" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    </comment>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_motif"/>
    </dbReference>
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        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
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        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
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            <end position="265"/>
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        <source>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
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            <dbReference type="EMBL" id="ORY34321.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="344" mass="36817" checksum="F2FBDBDFAAB97ADC" modified="2017-08-30" version="1">MGDQSRALHTPPSSSSGSSSTFQTGLKRSPSKTPRPEMQMSIAQAGHPQGQQQPQRPAPPRFHHYAPPPLAPYVGRDERVVPPTPSAEGWLRHDAPSHPTHPSIPPPQRPAPPHIPPPPRAKQDTAPPSPPASRGQYPADEGAEGYSDGAARTHSAGSAQSGLSASSARLDGDISSSPEGKRSRDHATSETAASGSSSEQTEPKPRKRTRVLMTHMQGTRLAALWHENRFPSTQQREELGSEVGLTPRQVQVWFQNRRQNARKQFNQAGIPEGANVAEYEDLQKSPRSRRLSMGSSAQEDRTSRWAASSSSTGYTSVSSYSRASGSGIGGGLASIGESASELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHT0</accession>
    <name>A0A1Y2BHT0_9TREE</name>
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        <submittedName>
            <fullName evidence="6">Putative peripheral protein of the cytosolic face of the mitochondrial outer membrane</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">BCR39DRAFT_477319</name>
    </gene>
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        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="ORY34344.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="759" mass="83396" checksum="8435FBA9826E2430" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
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    </protein>
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            <taxon>Naematelia</taxon>
        </lineage>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
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                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
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                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">68-887.2</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
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        </location>
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    </feature>
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            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ORY34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="913" mass="97725" checksum="D4D8CDC30C977A4C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJA0</accession>
    <name>A0A1Y2BJA0_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_515119</name>
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    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="3">Chromosome</location>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BJA0"/>
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    <dbReference type="OrthoDB" id="5586015at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
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    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY34846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="263" mass="28310" checksum="B513171E66B9778B" modified="2017-08-30" version="1">MPPPHPLRRISTGSLSSLARSQDRAPQSSSGLDFLAPALTELADEAATLAANVQHLNELHDALGTFNESFAGWLLALKMNAFCVEWPLGPNEVSFLRAPTLAPPPPPVLSILHNPNTIPSSPTPGQTQSDHPGDMTYATSYSNSTEDQPLPPKKVGTGPGLGVKKGIMKKPPAERKKRELAVSAIIDTLPLEYRGSQPSARLAMEKIINKLMDNPSGLPIKEMVSQPDLPHPRVNKCLIALVSKKAVTKVLVEGSTWYKWVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJB8</accession>
    <name>A0A1Y2BJB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_514022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJB8"/>
    <dbReference type="FunCoup" id="A0A1Y2BJB8">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJB8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJB8"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000707">
        <property type="entry name" value="CAMK/CAMKL/CHK1 protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="475" mass="52445" checksum="807158310C052E74" modified="2017-08-30" version="1">MQVDGPSTLRYPSIKGYRLGEEIGGGGFSKVFRAIDDTTCRIAACKVINLFISPTLGYGTPNVKELQKEVQVHKSLRHQYILEFLHSEVVDRDREAEGWVPGLYMLLELAIGGDLFDKIAPDVGVPEDLAKFYFSQLASGLEFIHSKGIAHRDLKPENLLLAANGNLKISDFGLCAVFRHKGKSRLLSGRCGSLPYVAPELGGPSGSGYAAEPVDIWGLGVVLYTLLVGNTPWDEPSENSPEFRAFLTRELLQYDPWTRIKGQAKAILLAMLTVDPNQRITMEGIKGHPWCMTPSQLNREQMADALTQGLRSTGMMAIADPTFASAASQAYASARSQRVVGDSQWASQLNQQESQFMRATGNITQGGDLNNNTTRFWLALKPTDCLRLLVPYLQNELGESNVRVDESRAHITVAKAAGYKSVQGTFVIRTSDSLAAEGHSLVTMKRAKGSILHWRAFWWSIVRQQQIEPYVVKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJC2</accession>
    <name>A0A1Y2BJC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_515317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJC2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJC2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJC2"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10207">
        <property type="entry name" value="ASKHA_NBD_Arp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="575" mass="62521" checksum="479D5D9AFCEC66BE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJD4</accession>
    <name>A0A1Y2BJD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_592364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJD4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJD4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJD4"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="322"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="823" mass="90165" checksum="3861C74B08C52236" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJD5</accession>
    <name>A0A1Y2BJD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_515367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJD5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJD5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJD5"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="448" mass="49084" checksum="CBE37F9412D1E6A0" modified="2017-08-30" version="1">MYGQQQGYGQQPPYGAPPQQGYGAPQYGAPQPGYGAPPPGPGQYGAQQYGGQQGYGAPQQYGSVSPQPPYASPQPPYGAPPQQQWGAPAPPPQQSYGGYGAPAPPPAPFMGGPGAGPHFLGVPIPAPPPAVPLTNLNGYNPQFDAERIRKATKGFGTDENTLIDTLAPLDAFQFDVLSRTYEQTVGRTLQKTLEKELSSWLEFTLVLLALGPLHGDLHLLHRACAGAGTHEDLLNEVLLGRTNEEIFLLKEGYRRLYHKDLTAVVRGELSAKTERMFNMALSGSRDESTFVNQQLVQQDVESLYRAGPGKIGTDEINICGILLSRSDAHLQAIAQTFPQRHRHALSHMIHSEFSGHMRNALLYVVRGAENDGRGVVRDAEMIGEAMSGMGTKDERMIYRIVRAHWNRPRFNAIKTQFQATHRRSLRQRVESETTGKYERALVAIIDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJV2</accession>
    <name>A0A1Y2BJV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_516343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJV2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJV2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJV2"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="682" mass="76288" checksum="63BC3FCE1B852D22" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKN7</accession>
    <name>A0A1Y2BKN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CFAP74 fourth Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_2214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKN7"/>
    <dbReference type="InParanoid" id="A0A1Y2BKN7"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056310">
        <property type="entry name" value="Ig-CFAP74_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211:SF1">
        <property type="entry name" value="ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ASH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24798">
        <property type="entry name" value="Ig-CFAP74_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP74 fourth Ig-like" evidence="2">
        <location>
            <begin position="771"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1518"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1819" mass="195033" checksum="8D9A22C249400F0A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL46</accession>
    <name>A0A1Y2BL46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_461594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL46"/>
    <dbReference type="FunCoup" id="A0A1Y2BL46">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL46"/>
    <dbReference type="InParanoid" id="A0A1Y2BL46"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="111"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="206"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="297" mass="32052" checksum="2A012EBBBA08D661" modified="2017-08-30" version="1">MSELLSPPPHTPSLRLSQTQKDLIGGSIGGIAQVLVGQPFDIIKVRIQTAPTGTYASPLDCATKLLKNDGPMGFYKGTLTPLLGIGACVSIQFGALEWSKRTFGAPDKDCVFLGELYASGAIAGVANTIVATPVEHIRIRLQTQSTFAGPLDCARQLYASAGIAGIMKGQVSTMWRDGLGYGSYFLVYEWLVQNHVEKHGVDRKDIAPIWSVTYGAAAGYGLWATIYPVDVIKSKLQTDSLDPTKRQYSGMIDCATKVWRAHGWRGFTGGLMPTLIRSPFANGATFVAFELAMRAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLE9</accession>
    <name>A0A1Y2BLE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_489409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLE9"/>
    <dbReference type="FunCoup" id="A0A1Y2BLE9">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLE9"/>
    <dbReference type="InParanoid" id="A0A1Y2BLE9"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:apoptotic DNA fragmentation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable NUC1-dna/rna non-specific nuclease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="13">
        <location>
            <begin position="74"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="12">
        <location>
            <begin position="75"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY35593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="370" mass="40340" checksum="FAC747DD2C001299" modified="2017-08-30" version="1">MPTLGPSILFAAGLTLGVGAGVLYPRRTTSSDVQIPPPPPEGGRDVARSPVKTASGSAVVVQGGFPGPIADVVKRTAYTAAYDRRLRHPAWTAEHLTAASLARTPSPSSPNTQPVPLDAARAADTTPDPPVKADRSRSTFMEDETIPELFRAKLADYFRSGYDRGHMVPAADAKISQQAMDETFFLTNIAPQVGEGFNRHYWAYLEDFCRRLTTNFEDVYVFTVPLYVPTLHPDGKYRVTYEVIGDPPSVSVPTHFAKVILASRPDFSYPQRASASDKAISSSNSVKELAMGAFVLPNKEIADEADLRSFIVPVEHVEKTAGLQLFNPELKSRSRQLCAVTQCQLVVRRFDDARKSYGKGQKGSQGRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLP4</accession>
    <name>A0A1Y2BLP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_585297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
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            <end position="271"/>
        </location>
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            <end position="607"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY35682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="672" mass="74158" checksum="24F359EDD094E9A6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLT5</accession>
    <name>A0A1Y2BLT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor of growth protein N-terminal histone-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_511740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BLT5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLT5"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor of growth protein N-terminal histone-binding" evidence="2">
        <location>
            <begin position="86"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="440" mass="47501" checksum="6BBA32DCBA6E890C" modified="2017-08-30" version="1">MPRKSLPAPSSTPLTSLRSAPATSIKRSRSRKEIYDPSASPSRSRKKRRLETPTPTPTPEPAAGEEAGGDDEADEAEKDLEAWQDFAAEHYEMVEQLPLELHRNFRLLRELDDGCLAQTEKLHALIREYIAYRLPPPTDTSEVIRHEDSGQVEEAQVNGQGEIAQQPSTSNDNLHSTPPSRSGEESLLHSSSNAEEPYETPEPVEYDLHVPLKPSEPSAPETAEEMGVPLPDGHGGLLLPMEPAEPAGDVEPRREFPAAQNTSTQSRSGGKVNGSTDDGKGEVASQIEATAGPSRTQRATKPYLPEIGKLIREVVRNGEEKLAVALGAYNIIDRHIRALDQALDAQEASIVLGLRPSTMPSHSVDPDQEDVAQETEQVQDEGEVTIGLGGAAGGRSRKKGKKGKKVQEPVPAPAAPQLHPSGMPLDFVADPYGYPPTLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM00</accession>
    <name>A0A1Y2BM00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="7">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_511920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM00"/>
    <dbReference type="FunCoup" id="A0A1Y2BM00">
        <property type="interactions" value="684"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM00"/>
    <dbReference type="InParanoid" id="A0A1Y2BM00"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="10">
        <location>
            <begin position="246"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="9">
        <location>
            <begin position="520"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="723" mass="79972" checksum="ED882C64F61A8858" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM79</accession>
    <name>A0A1Y2BM79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_511557</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM79"/>
    <dbReference type="FunCoup" id="A0A1Y2BM79">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM79"/>
    <dbReference type="InParanoid" id="A0A1Y2BM79"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="127"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="220"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY35697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="311" mass="33867" checksum="9F91BF8E382B2622" modified="2017-08-30" version="1">MAEPILPAKSDIKAQHHLLAGALSGLSSAISLQPLDLLKTRLQQGYEAGGPKRRRLRVVVRQVLHDDGIFGFWRGTVPTLTRNIPGVAIYFYTLSTIRTRLSSTPYFQKIVPDPSAPRSSKSALVKLSSQGNLVAGAISRTSVSFILNPITVLKARYESNFYTEYHSLLSAFRSLLATNGVRGLFQGFTATAVRDAPYAGISLVFYEKSKDFLGRVSSLPNAVLHSASGASAAMMATLATSPADCVKTRMQVNPQDHPTIRKAVIRIYNDRGIAGFFSGSTLRISRKAGSGAIAWTVYEGLLLFLRDYQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM96</accession>
    <name>A0A1Y2BM96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_38426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM96"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM96"/>
    <dbReference type="InParanoid" id="A0A1Y2BM96"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="526" mass="56667" checksum="45A4D5EFC27B9DCB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMF6</accession>
    <name>A0A1Y2BMF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative Imidazoleglycerol phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_512724</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMF6"/>
    <dbReference type="FunCoup" id="A0A1Y2BMF6">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BMF6"/>
    <dbReference type="InParanoid" id="A0A1Y2BMF6"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY35870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="606" mass="65849" checksum="2C7E98033A8E4DB7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFB9</accession>
    <name>A0A1Y2AFB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AEX-3 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_553921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000114">
        <property type="protein sequence ID" value="ORY21289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFB9"/>
    <dbReference type="InParanoid" id="A0A1Y2AFB9"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cDENN" evidence="2">
        <location>
            <begin position="592"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1373" mass="152002" checksum="7088F40FD1DD57DD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG83</accession>
    <name>A0A1Y2AG83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_553356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG83"/>
    <dbReference type="STRING" id="71784.A0A1Y2AG83"/>
    <dbReference type="InParanoid" id="A0A1Y2AG83"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="399"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="2">
        <location>
            <begin position="741"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="835" mass="92048" checksum="311F0C685CB7CF76" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHY3</accession>
    <name>A0A1Y2AHY3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_50436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000104">
        <property type="protein sequence ID" value="ORY21797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2AHY3"/>
    <dbReference type="OrthoDB" id="10646755at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="212" mass="24936" checksum="A1ADDED9351CEF09" modified="2017-08-30" version="1">MYNEGSANKTPDENEKENKEADAAAKTRSTENENENENAEENDTDQNHLPITRTAAAKQKSRAKRDSEREMISQFNQLIKKLLSRYKKYKKGTKDAKDSKALSRTWKRCQVSADELTQRIKVAKFRVKGPGRRYHMGAGFFHNLPFEFFSTTKLLFLRDDTSPKEKVWKKSFETLAECYALACKWPEVGDIERKNWQDRNEWGYVRMYWESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI82</accession>
    <name>A0A1Y2AI82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_552063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI82"/>
    <dbReference type="STRING" id="71784.A0A1Y2AI82"/>
    <dbReference type="InParanoid" id="A0A1Y2AI82"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY22182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="92" mass="10180" checksum="EB91C8762C7F4012" modified="2017-08-30" version="1" fragment="single">MTDLSCSVHTLSYLRQTSPILFSTVLACASRFFRKDLHSLLLSHASTILDRASNSGVADIGIVQSLMLSTYWKAPEDTSAWRKIGMAVRLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ97</accession>
    <name>A0A1Y2AJ97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_385607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ97"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ97"/>
    <dbReference type="OrthoDB" id="2575565at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF2">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="478" mass="53517" checksum="FC8E9A526F4CC832" modified="2017-08-30" version="1">MPRPSLPRYVPAGPSRLPKPQHAQPPPPAPALLFNHEPEPLRLSRPHLYRAYLQHIRFIPDPHIWLMMIPRMKELCRHREALDETSDGYSSLVKPDVNDNDADDLPMGVVSFELERIRTLKRARKELAGMRAAVACHPHALQRLIERAYGQRGRIRRDLITRICETSPPPAPHPAAYLLGSGRPDLPPPLQATRPAPVPPQPASPRARQYVPKKAGKRKAVANWARDWDRVLVPLVLPQWLPRGQPSAMTGWEGCGVVESLRVLTGDDTGQVENGAQPLPLPSPTPTPSSSPSRYPIPDPRKLSTFLSLPANLQRLFPVNLPASTRDLERYGVPRRRETRANPSTWRGPRPLTLRLLQRIYRRFWDTLVWVRPADSGAWVRCSFHEMAAWEKGTELQDIPTMAGLKKRRKKGPMAVPFEQARFAHATEDEARWLEPAQAGSTLGNSPAPTSPINDTSTSPTSDKSIRTAKQTPISPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJW3</accession>
    <name>A0A1Y2AJW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation transport protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_550794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJW3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJW3"/>
    <dbReference type="InParanoid" id="A0A1Y2AJW3"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY22841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="596" mass="67230" checksum="1AF3426516CC7311" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKY1</accession>
    <name>A0A1Y2AKY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WLM domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_549816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKY1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKY1"/>
    <dbReference type="InParanoid" id="A0A1Y2AKY1"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="5">
        <location>
            <begin position="10"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="482" mass="53372" checksum="A28380E69CF49B6F" modified="2017-08-30" version="1">MQAPGFRMNEREANPNPYVGFIRALKGKKDAADAESVLKAVAAQMKKIMEQRFMFVHTLEEAAFNRVFAGRNWNHGQSIELVLRGPSGRFLPLPYITSVMCHEMNHGPKFQKLMASIKKDVREMQARGYFGDGFWSDGRRLKDSVKMGAEGLKPSDFPEYVCGVSASDAQKARGPRRGPSASQTPGLVKGEASHLSGRQTEYNPKGARRVNVDMGENGTRLDGKREITKEDRAARKTFIDEEVDKLVKAGLPITRAKTVAIEMYDKLHPWYKEGSTFGKKAKSKTAVEMRAEAAERRLAALQPKLEPPEEDIAENGTLEIWDLTSEEDVPDPHTDPQARKREMEESMTKEELHDLKGGWEDYVITSPKKRAASPSAIGSSSSKKTKQATLFGAQIIKEEQLRGLGLASSSSGKSSRTSRQAGATMTVDDSPARRSDESSMRPESPSTRPGWTCKLCTFINVSNNGRCEMCRARPDGTIPSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALJ9</accession>
    <name>A0A1Y2ALJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_549455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALJ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALJ9"/>
    <dbReference type="InParanoid" id="A0A1Y2ALJ9"/>
    <dbReference type="OrthoDB" id="2564890at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="298" mass="29160" checksum="1041C7234AAD4627" modified="2017-08-30" version="1">MDLGAPIGNVAPRAGFDEGEHGAGTGLSGGYGQVNSQNTQQGIAAAEESSGFNSGLGGAHASSGIPKDYSQSTPIADKYMTGTTAGSTLDSYSSSGAGYAGQKETVSGAYAGGGTGDALTGQSQASTTGPGVGVLGENANSGSGEQHHHHHHHHHQQQSGAGAGNPRTAAMAGTAAGAAAAAGEESETRLGGETGTGVGASGGAGGHYSSNEYRETSDSNYSSGAGAGAGAGVGAGAGANDASKAKGHYGHAEDDETRGQPISNPHDLDTGGRHSLVFDEASGKYLHRHEIEGTTRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM04</accession>
    <name>A0A1Y2AM04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_591012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM04"/>
    <dbReference type="InParanoid" id="A0A1Y2AM04"/>
    <dbReference type="OrthoDB" id="2564657at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="117" mass="12930" checksum="CC9E3941F1BFB08C" modified="2017-08-30" version="1">MSTSFYSNSSTSPKKRQATSSPPLSDDKPVTVFPTTPKKKSKVNGHSTTPKLTPGKNKGEGWTAEKRIKLFEAFVHVAAVDWNSVAVKMGDGTTGKMCREQWQRAMGKKIRKALMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMK8</accession>
    <name>A0A1Y2AMK8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMK8"/>
    <dbReference type="InParanoid" id="A0A1Y2AMK8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="76" mass="8507" checksum="65FE772B7AB0524B" modified="2017-08-30" version="1">MLAPLTISTTPALAGLTGTMRARHLNRPASTTLKFRPLTRNSYLPFSPRHSPLAQGRRCSRPPDNRQHFSHPFSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ17</accession>
    <name>A0A1Y2AQ17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_546139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ17"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ17"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="106"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="316" mass="35233" checksum="3FDF82932CDD621A" modified="2017-08-30" version="1">MASVRRSSSLTKFNVRTRTGIITPRQIFERKMSKHPPFEDVEASRPDFDVDFKHVVTKVPLPGFKPGGGLNNNLPYAKDFEANVGKFITFSAEERKPADIYKLLISSATPRCISFNSTLDENGIGNLAPMSYFNVVSHDPPTIMISVQAGKKHSDGLKDTNHNIKTTKEFAVSIISEPFLEASNYTAIDAPSDIDEWKLSGLTKRKSETIKPPHVAESPVSMECELMHWYDIIGASGETSNTVILGRVKKFHIKEFVLDPADPMKVLVEKLRPMSRLGGISYGRTTQTMEVPRPVWEKVKDTPEVQAALAAEEKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ60</accession>
    <name>A0A1Y2AQ60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative ergosterol biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_561425</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ60"/>
    <dbReference type="FunCoup" id="A0A1Y2AQ60">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQ60"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ60"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY24681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="134" mass="15035" checksum="163B3C41018DB430" modified="2017-08-30" version="1">MSYLPDSSRGILPYWLLLTSAASVYNVFQSYTTTWQSKEVYAGRSAEMTPLASRIFGSWTLTAAMIRTMAAYNVSDPTAYHLVMGTYIIAAFHFGSELFVFKGVKINRASIPVFIVATVSLVWTYNQRAYYLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ80</accession>
    <name>A0A1Y2AQ80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_546691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ80"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQ80"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ80"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012146751" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="208"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="292" mass="30182" checksum="0A92675F5A2FAEBB" modified="2017-08-30" version="1">MFQFKSLRTVVLITFFASMGAVQGGGLLDDHYNVLSKRLTANVCATINPGIDVYIPLVGTEHIALASSTCLCLSGGVLTPTSIASLKLSVQTSDGTGTVLGDAVAALGLTNIVNLFDSAAITLLGAQPDSGCNYPSGAIPRDCGTCNYDCPNSGFVCGSTCVDAGSVCVSGKVVKSRRRSLDSSPFLCPKDLTACAIPGSNVWTGHNFECIDTQNDIESCGACADPIPGQPMGQDCTAIQNTNRVACQQGACAVLSCQRGYEVDSTGTSCIAGLVNQSGNSQKRSGPRRARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ86</accession>
    <name>A0A1Y2AQ86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_547603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ86"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQ86"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ86"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="479" mass="52144" checksum="937885FEE5F087FA" modified="2017-08-30" version="1">MDITLLPPTHILSHHSHLALLPSAFPRRRGQPSSNLIPTPYPRAPFTTYSFKRRAFECLAPLDGSSPISTLPDEVLLHIFGFMESDEILPLRAVNNHWSSLALTPSLHHTLTLTSLPPTPLPKILSDHILPAVRHLHLHLCPYPSTFHPWKRDRPPSDLQELLGAIPPDKLLSFSLPFSAPYLPSADLVEVLGRVGGRLEKLDLRGSGLAGSSWVHTLEYLGSRGGGIKELDLGFTGILALPSSWNNLTSLSLASCSHLPSTVMTTYLANLPPSLVQLDLSRLDQVSFNALWDMRVTTPEGDATALNEVKVVGIDHLTRLDIRRLKIHWASQRRSTNPISDLATPLVRPPTRSTPIQISSYRPRTPSPRGFSRSLGSSTSSSAGDSSPDLRTPPDWSSHTRILNSYPSADKAFVKPLEKTVAGIHVLHSAILESEDEAGYRQFIGDVVGATVGLGGGTAWDPVYGDDGGVYVEIDGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR35</accession>
    <name>A0A1Y2AR35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="5" type="ORF">BCR39DRAFT_317561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR35"/>
    <dbReference type="FunCoup" id="A0A1Y2AR35">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AR35"/>
    <dbReference type="InParanoid" id="A0A1Y2AR35"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY24687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="487" mass="52684" checksum="F8686395CF9A2671" modified="2017-08-30" version="1">MSCGNEPDVAPDGGQSGGEALMPRRRQVRRVDRAICQKCKTAKSKYIMHSATFCPACFESTLNVRFLRTLFPALRPPHSKVKDLSRPPLQKGNALIGLSGGAGSVAMLDLLMRFGLIGRGTGARADLTKGEKEVVWDWATVVHVRFEEDVEKETELQRVVEGWGLQWMLLKAEDVFDSGLRQRLGGTQDDGPELGVDLHYHDLPLTELSSSSSLTPREKLLSLLTALPPASRPAMLQSILDHLLTFTAATLPNISHLLLGETATRQAQRVISGTALGRGWALPLDLAAKRSTSGDVVQLKPMRDIGSKETAILCRLRELASWNERRWFLGPEGKEKGKGGSGTRSIEGLTERFIAGLSVSHPSTVSTINRTGDKLVFPGETGSIASCPLCESPLEPSALDWKSRTALTSLSASTVTVPKNRKGDGKGLGLANMLCYACLTTLSRSPIAKHSPSLLGQGSVPLPLWVSAHVGRGTIEQYLIGQDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARD0</accession>
    <name>A0A1Y2ARD0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARD0"/>
    <dbReference type="InParanoid" id="A0A1Y2ARD0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="137" mass="15562" checksum="55A44F3CCA6DAC93" modified="2017-08-30" version="1">MSFKYPVLPIVRVQEEKIPLLGQAKVSRSEQDVKLQVEEENKDDDIRPSLAEASRLLILLVFAAVWTGLAIFLTPLSPTPTRRTIGWILVGVWASLTTFLGARLAIETLDLWRESRMRERGRRLLFVGDECEKTGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARZ2</accession>
    <name>A0A1Y2ARZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_590239</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARZ2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARZ2"/>
    <dbReference type="InParanoid" id="A0A1Y2ARZ2"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY25246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="448" mass="49929" checksum="0B2A3A104E8D57FB" modified="2017-08-30" version="1">MAERGIFSLLLALVLFVLYCVIWALCVLGWRTARTRYAGRLMPSRMESLPSSSAPGVTIIRPLCGLDNNLYNALESTMKLDYPKYEVIFALQDEKDEALAVVKMVIEKYPEVSTRIIIDDRKVGVNPKINNLMTPFEQASYDLLWVIDATISVGPGTLGRTVDAFLETSSFSSSFDSDLESTQLMSDDMRKPPVKGDVGLVHHVPYAVVYQRTWGSLIEQAFLNTTHAKMYLAINATAVDSCVMGKSNLYSRANIASLTTPSPTLRSRPNPPSGLAGFSPFLAEDNMIALGLWHELGLKHAMTSDVALDFLGALSVRDYINRRVRWIRVRKKMTPIFAVLIEPFTESILCGIYGAWAIDRIFIANRVAIFFVHMVIWLLLDLSVRRSLGANVKGIGPPSSTPLFVVAWLAREVLTLPIWLYGIISSDVTWRGKRYRILNSGEAVALDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASG4</accession>
    <name>A0A1Y2ASG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_561039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASG4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASG4"/>
    <dbReference type="InParanoid" id="A0A1Y2ASG4"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000658">
        <property type="entry name" value="COP9 signalosome complex subunit 4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="232"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="462" mass="51150" checksum="76810F52830F71D5" modified="2017-08-30" version="1">MEVDSDIDDKLSEIASFPNQRDRTTSYLDLLKSLLSSKPSPTPLIAYGRHFILSSSMATVVGRRVLGAFVAALCAGSGMDKVESLTSSDVEEGAGDEEHWERLGKAAFEGEKGAEIRKEVVDGVLSDGARGGWCDEQVTALRHLQSYLLQLEEDWVGAARVLMQIPLEGGSRLISDEEKLRVYMKIVRLCLESGESGLAQNYFSRASLLIHTTKDKETQLAYKLSQARIFDYSARFNEAAQRYHELSFDGAIDEDDRMHMLKAAVTTSILAPAGPQRSRTLASLNRDDRVITSLPAHLPTMLKKMLLEYIVRAEEVKEFEAGLEEHQRATVEGGGTVLERAVREHNVGACGKVYDNVSFDALGTILDLDSDAAEATARRMIEQGRLRAWIDQPLHLLYFESRSTHDTDAEAQGTAGGLGVEREEKDVEPVSWTERWDDRIRATSMQVEAIASTIQSRGLIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASN1</accession>
    <name>A0A1Y2ASN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_545340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2ASN1">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASN1"/>
    <dbReference type="InParanoid" id="A0A1Y2ASN1"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="236"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="286"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="650"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="799"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1276"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1063"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1185"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1229"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1295"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1381"/>
            <end position="1395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1418" mass="153706" checksum="CB09A8A630C58A23" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASR6</accession>
    <name>A0A1Y2ASR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_544365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASR6"/>
    <dbReference type="InParanoid" id="A0A1Y2ASR6"/>
    <dbReference type="OrthoDB" id="2563251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="197" mass="21447" checksum="475BA630F88C9551" modified="2017-08-30" version="1">MAQTLTNLVQAIHLPSSSSPFLLITSGPSDQIITLHLLTITGTSILSWTGNIDSPPEDSEEAKNLSEAVMEGYLHLDLGRKIPSETRDISLHILPPGHTPIVIALSKTEEDDTDVRLFQTCLKLLERSIPPDASEIRTLRTEISAKDAEISHLTARLASAKATVARTSTAESKKKQMLSPQKKVPVNASALQPNQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATB8</accession>
    <name>A0A1Y2ATB8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_543937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATB8"/>
    <dbReference type="InParanoid" id="A0A1Y2ATB8"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="702"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="907"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1110"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1304" mass="142339" checksum="DF2BAD9930CD2957" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATS2</accession>
    <name>A0A1Y2ATS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_600061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATS2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATS2"/>
    <dbReference type="InParanoid" id="A0A1Y2ATS2"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="639"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="737" mass="79069" checksum="347776795EEE55BA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATS7</accession>
    <name>A0A1Y2ATS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_542702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATS7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATS7"/>
    <dbReference type="InParanoid" id="A0A1Y2ATS7"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="279" mass="30687" checksum="F14EE7A73A526AB7" modified="2017-08-30" version="1">MPKDQTHRSRPHAASSTSGAGAGAGAGAAGPSYKALPIEKRDPTGLAGVSKLKASIRQTKRLLAKDTLDPGLRVQTERRLKSLEADLARAERRGVEKKNGEKYHMVKFFERQKLVRLIKRLGRQSDTLSELEKARVMLNYVLNYPNERKYISLFPSTSSTEPSTKPSLTLPNLLPNSDQPDPDLTVLGKGEKRRMEMLLRVRNMMRDGTLPAQPEKDLQDRDGQGDGEREARNRGARTAMGLGDELVAGVGGTEVGGHKGKKGKNVGAQEQEDEFFESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATT0</accession>
    <name>A0A1Y2ATT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">chitin deacetylase</fullName>
            <ecNumber evidence="14">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_543502</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="14"/>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATT0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATT0"/>
    <dbReference type="InParanoid" id="A0A1Y2ATT0"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF135">
        <property type="entry name" value="CHITIN DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013096017" description="chitin deacetylase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="17">
        <location>
            <begin position="125"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY25637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="431" mass="44960" checksum="F4C538FF7955FC6F" modified="2017-08-30" version="1">MVHFAAFPAVMALVAGHTLAAPLGDWYQAADSSVAAMFHKRYTPSPSDANFTSNYPTGWTTPTSDTLPKAWTDKLASIQMPNVSVATQNNGYPTYPNGESGADSTICSFTYECTTSDDLLNPPDGVLALTFDDGPTDYSEELYAFLSQNNASGKATHFMIGGNILGSPTVMQDALKAGGHIAVHTWSHPYMTTLTNEQVLGELGWTMQIISDLSGGRVPKFWRPPYGDVDNRVRAIAKGVFGLETVPWNQDSADWAIGTDAQYTNASVEASINQWLSGSKTPGLCMLEHELNANTVGVFENVYPNMVSNGWNVKTVADAWSLDWYQNAADDTATVTSMAIAGDAVAQSSTASSSSAVSSTSASSKTTSTAASVSASSTSAVTSTTASSAQSSANASSAAAVTSKTGAAGRVQVGAGWAVVLFGAVVGVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATT8</accession>
    <name>A0A1Y2ATT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YABBY protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_543574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATT8"/>
    <dbReference type="InParanoid" id="A0A1Y2ATT8"/>
    <dbReference type="OrthoDB" id="667577at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056775">
        <property type="entry name" value="YABBY_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04690">
        <property type="entry name" value="YABBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YABBY protein C-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="68" mass="7628" checksum="B89CD59E91FA7FF5" modified="2017-08-30" version="1">MPPKKTSTPKKKTASKKGSGTPSAYNVYMKKKLEQLKKDEPDLLHKDKFKKAAASWATAPENPKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUQ0</accession>
    <name>A0A1Y2AUQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low-affinity phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_470499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUQ0"/>
    <dbReference type="FunCoup" id="A0A1Y2AUQ0">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUQ0"/>
    <dbReference type="InParanoid" id="A0A1Y2AUQ0"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="433" mass="47378" checksum="6132EAB3B9A5AB90" modified="2017-08-30" version="1">MRDRLRKPVFELVVLGSGGGPLETDCSGYLVKPYLSAWEDGILALEGVGSGLGALAMLLESKGEKSLFPTLKFPKTHDTPLLKAAYVFSYLACYLVTHAHLDHALSLIMLSGSVPPRPKDAAHFQAPLSAITPPAPEYALTSPRLPVYGTRRTLEKLAVVYGGDLWPELGSWAPERPLDVPEAERASTRKRRKAPDAHGATEGVCVSFSPLVSSKAHRPLDPSLPISTLTYPVSHGCTSHGRYESSAMFIRYDPGSITHSQNDESAQAGREFLFFGDLESGWRAQGEESVDVQSGQVAEEMNRAIWEEAANSWRKGKLAGIFIECSYDSSRPAHLMFGHISPPGLYHELQTLASLVSRPLDGLRIFITHIKDALVPHPSGKTSKERIIGELLELEKHGKLGLEFAAVKRGDRICAYLSEKSQRRSAEESLEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV35</accession>
    <name>A0A1Y2AV35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_542499</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV35"/>
    <dbReference type="STRING" id="71784.A0A1Y2AV35"/>
    <dbReference type="InParanoid" id="A0A1Y2AV35"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="170"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY26077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="601" mass="65418" checksum="C1C9A845D8543F39" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVI9</accession>
    <name>A0A1Y2AVI9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPR1/FUN34/yaaH family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_594810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVI9"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
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    </dbReference>
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        <property type="entry name" value="GPR1_FUN34_YAAH"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="77"/>
        </location>
    </feature>
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            <end position="107"/>
        </location>
    </feature>
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            <begin position="116"/>
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        </location>
    </feature>
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            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
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            <begin position="181"/>
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        </location>
    </feature>
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            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="249" mass="25942" checksum="0663ADD2D1D6B124" modified="2017-08-30" version="1">MSQQELKPQEQPAPANGVGAGAGYQGTGGQMSRFVTPGGNPIDSSQPAFPIYHRKFANPAPLGLMSFGATTFILSLYNVQARGITTPNVILGMALGYGGLAQLIAGIEEWACGNTFGATAFASYGGFWISFATLYIPQFEVVAAYGDAASELDSALGIYIAAWGIVTFIFLIACLRSSVALVSLFFFLDVTFWCLCGGFLGPSVNATKAGGAFGILTAAIAGYTALAGLLTKDTSHFILPVGDLSRGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVZ9</accession>
    <name>A0A1Y2AVZ9_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1360"/>
            <end position="1369"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1369" mass="149798" checksum="6058A5418C102F3E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW26</accession>
    <name>A0A1Y2AW26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP/chorismate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_497895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2AW26"/>
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    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF12">
        <property type="entry name" value="TRANSLATION INITIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="122" mass="13058" checksum="F855E2343455B14E" modified="2017-08-30" version="1">MQHFNAPEMPKGPGAHAVKVDATGTIYCSGWVPMTPDGQIITEIKEATKRCITNLGYSLKAAGSSWEKVVKVNIFLADINDFAALNEVYIPLMPNPAPARTCIQAGALPKGSIVEMECIAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW96</accession>
    <name>A0A1Y2AW96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_565898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW96"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW96"/>
    <dbReference type="InParanoid" id="A0A1Y2AW96"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="420"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="552" mass="59568" checksum="32154270FD5D8CE9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWB8</accession>
    <name>A0A1Y2AWB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_560289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWB8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWB8"/>
    <dbReference type="InParanoid" id="A0A1Y2AWB8"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="897"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="953"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1226" mass="136200" checksum="B6B2182CE250771C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWF0</accession>
    <name>A0A1Y2AWF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADPH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_484068</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWF0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWF0"/>
    <dbReference type="InParanoid" id="A0A1Y2AWF0"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="304"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY26889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="607" mass="68952" checksum="F64DA2A902A9D1B0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWI2</accession>
    <name>A0A1Y2AWI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_262274</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWI2"/>
    <dbReference type="FunCoup" id="A0A1Y2AWI2">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWI2"/>
    <dbReference type="InParanoid" id="A0A1Y2AWI2"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="216"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY26265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="879" mass="96333" checksum="D3AC3F63E11EBDB3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWW5</accession>
    <name>A0A1Y2AWW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_484181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWW5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWW5"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="551" mass="61720" checksum="E1D6C42345802543" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX84</accession>
    <name>A0A1Y2AX84_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_538866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX84"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX84"/>
    <dbReference type="InParanoid" id="A0A1Y2AX84"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="11">
        <location>
            <begin position="208"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="463"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY27189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="492" mass="52832" checksum="6261C1DEEFFEC2B4" modified="2017-08-30" version="1">MGLPDICSAFEPYFLLSDDKLRDVVKHFRGELEAGLAEYGKDVAMVPSFVTGVPDGSEEGTFLALDLGGTNLRVCEVRLFGHHKFEIKQQKYKVSDELKEGQARILFDYIADSVDAFLTDIGSDISNNEPMHLGFTFSFPVEQTAIDAGTLLTWTKGFAAKNAIGHDVVKLLQDAFDRKHIHVRCSALVNDTVGTLLSRSYQSGPALIGAIFGTGTNGAYIDKTRSIPKLGEEKIAQSEKGGQHAGEFMVINTEWGAFDNGRHCLPVSIFDNKLDRESINPRKQAFEKMVSGMYIGEITRNILLHMIDSSVLFSGYSSPIINTHYGYDAAFVSKIEGCKSLEEIKKAIIKDLGVDADKVSDADAEIVQWAVSVVAHRAAALAGCAIAAVILHTGNDKVPEDEEDTGVDVGLDGSVAEFLPDFDNRVRKALKTLLGDAGEKRVRMGLAKDGSGVGAALTALQAKKALDAHPNPDQSPTAPGKPGGKTGATGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX95</accession>
    <name>A0A1Y2AX95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_506382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX95"/>
    <dbReference type="InParanoid" id="A0A1Y2AX95"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="245" mass="26628" checksum="01721AA844FD1A98" modified="2017-08-30" version="1">MDGISSTQSSASLARSSASLAQSSVSLSQPSVSLSQPSTSHAQPSVQSNQSETFPTQGSTTHSTWHWEERRNSTQIKLHSDDGEASVGQIDTETNLPLSLLTCMDNLYRKSAEACEVNTDDDLHSTFIKWAGAHLWSLDKRGIEFTAEPEMTFRVNSDRSSKNAGPVSVTMTVQWGNGWSSGVHIPPDPKPDLRPLGIAPGPLNTDLTGTLFGPTMIRDSEVDALVPGSQDDFLPDPRDRWNCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXK8</accession>
    <name>A0A1Y2AXK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_228152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXK8"/>
    <dbReference type="FunCoup" id="A0A1Y2AXK8">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXK8"/>
    <dbReference type="InParanoid" id="A0A1Y2AXK8"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="392" mass="42675" checksum="8995CBF1940D0EF7" modified="2017-08-30" version="1">MGVVRFGVCVLGVYAAFLLWAIAQERLSAPFPSIYPEHTTGDKFPSPLFLNFAQATASCLSALIYLTVKSWRAGNLAKDGFAKILGISMLLSGGTSQRDEKGEVGEKLAVKQGRRVAWRKTLPALLLQVSIFQTIAGPIGFLALRHISYPTMVLGKSCKLIPVLLLNVLLYRRRFGAHKYLVVSLVTIGISMFMLFGDGGSKKGGSDSIYGLTLLGIGLFIDGLTNSTQDQIFATYPQFTGQQMMFTMALLTQLLLLPIMLLPLPSHPLSLLHLPSPLASTSPVTFSPPAFLESLHFLLTHPTAVSPLLAYALLGGLGQLFIFETIQHFGSLTLVMVTVTRKLFTMLLSVVVFDHTLSKGQWAGVAVVFAGIGVEAGMKRRDVMRKTRRDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXP9</accession>
    <name>A0A1Y2AXP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_538397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXP9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXP9"/>
    <dbReference type="InParanoid" id="A0A1Y2AXP9"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="11"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="536"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY27341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="595" mass="65484" checksum="5EE50691BECCF678" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYM1</accession>
    <name>A0A1Y2AYM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_539493</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYM1"/>
    <dbReference type="FunCoup" id="A0A1Y2AYM1">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYM1"/>
    <dbReference type="InParanoid" id="A0A1Y2AYM1"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="3"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="15">
        <location>
            <begin position="201"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="14">
        <location>
            <begin position="351"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="584"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY26955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="678" mass="73880" checksum="98D46AA270A0DECA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZF2</accession>
    <name>A0A1Y2AZF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_469152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZF2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZF2"/>
    <dbReference type="InParanoid" id="A0A1Y2AZF2"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000135">
        <property type="entry name" value="LIM domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="498"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="638"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="695" mass="76303" checksum="04CC275D28F3CA49" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZI2</accession>
    <name>A0A1Y2AZI2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_594350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZI2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZI2"/>
    <dbReference type="InParanoid" id="A0A1Y2AZI2"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="333" mass="36240" checksum="A7FFBFB797664776" modified="2017-08-30" version="1">MGSYFSSSRFDPSRDIPSLKGKVILVTGANSGIGYQTAVYLALNGARVYVGARNEGRGLEAIKKMEDDHPSLRGENRLLPHELDLSTMTSAEKSALAFLEREKRLDVLVNNAGVGNSSYRIGPEGIEAAFVVNHLAQFVLTTTLLPLIAQTASLPDGDGRIIAVSSDAHNLVKNNPKFASVDDFNSIVAPKVKVANTFYNRTLRYGMSKLANVLFSKELQRRLLEDESTSEIISLAVNPGLVDTPATKRSLWFLYFVPKSWVFYTPLQGASASLFAAASPIVRENSALYRGAYLTSFGKISKPSQLGQDNQLARHLWATSEAVVEQTLAKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZW0</accession>
    <name>A0A1Y2AZW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_536112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZW0"/>
    <dbReference type="InParanoid" id="A0A1Y2AZW0"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="274"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="634"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="802"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="889"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="942"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="974"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1204"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY28004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1314" mass="145361" checksum="0B2AD6C39C78A722" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZX5</accession>
    <name>A0A1Y2AZX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_559876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZX5"/>
    <dbReference type="InParanoid" id="A0A1Y2AZX5"/>
    <dbReference type="OrthoDB" id="2562427at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="236" mass="25340" checksum="292B84530ACFAEBF" modified="2017-08-30" version="1">MDALLSQIASYLPPDLQAIVLNPPSLSRPSSFIPALRIIVPYTKYVVVLLAFYIVWSTISSVVGYFSRFMRFAMRIGPVLGFIAWVMAASGQGGMDELFQSVKEWTGLANAGNNIGGRSPGIANLANLFGMNTAPKQSSRKRRTTGLGNLFSSDTDPVSSRTRTKGKKAVDQDSDFVSQLLRSAVGVGAEGNGGNVQDVVQSYVKDALAKAAGLSWLFGQHNEGEETEARSGSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0L9</accession>
    <name>A0A1Y2B0L9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_536339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0L9"/>
    <dbReference type="InParanoid" id="A0A1Y2B0L9"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="28"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="569" mass="62759" checksum="ADE466B7204C5591" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Y9</accession>
    <name>A0A1Y2B0Y9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral peroxisomal membrane peroxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_565599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Y9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0Y9"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Y9"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="6">
        <location>
            <begin position="110"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="525" mass="57453" checksum="68B6674EFE7E14A2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1H2</accession>
    <name>A0A1Y2B1H2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_468195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1H2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1H2"/>
    <dbReference type="InParanoid" id="A0A1Y2B1H2"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF4">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="289" mass="31980" checksum="69540479625DF933" modified="2017-08-30" version="1" fragment="single">GNCIGRGQFGSVYRSLNLSTGQMVAIKRIRLHGMEEAEVRDVMREVELLKRLAHPSIVKYEGMSRDEEYLNIVLEFVENGSLGQTLKAFGNFNEKLVSSYVAKILEGLDYLHSQGVVHCDLKAANILSTKNGNVKLSDFGVSLNMKAVENIRQDATQGKTTSRDVAGTPNWMAPEVISLNGASPASDIWSLGCTIIELLTGKPPYAEITNSMSVLFRIVEDEMPPLPDVSPDLEDFLKLCFIKDPKHRPEAVVLFEHPWVKKLNPEIVRQDFTLGVPYLTNVSGTTTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1S8</accession>
    <name>A0A1Y2B1S8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_533728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1S8"/>
    <dbReference type="FunCoup" id="A0A1Y2B1S8">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1S8"/>
    <dbReference type="InParanoid" id="A0A1Y2B1S8"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="474" mass="51192" checksum="76B8951A43C34B53" modified="2017-08-30" version="1">MAPSVPLAYPTLSNPLPSRPYILSITPTLSSSSPHLLLRHPSPSITIADNQTLQPVEVLQGGHGGDVTDITVDESGGVWSSAKDASIVRWDERTRQPAMTIKAFVRKPLPVLAMTVSERDHLVVAGTELVSSEAHILFWDMRNHKTPAYSHASTHSDDITHLSLLPPTSSFLPSSSSFPSRLLLSTSTDGLVALSDLKEADEDEAVQAADNWGQSIAGAGCYLHRRGLKVWARSDMDGVCVWSLGKGVVEDEDGEVVEMQNPVEYGSDNFKFRDFNPPSTLPSTARSAEEERVDKAGRLTSDYLIDVAPSLGVGKHGGPMVAVGTNAGDIVLLHQSSTTSPSYIPSAFLASGPSPNRGHADVVRSIFHDVQNEALYTGSEDGVLCGWSLASLPERLRVGDPDIDDDGGDGREGIDRADEESEIESDDDDDDDDGMDVDDDDEEEGEEGPRYGPVLGRAAGDRREKRREKRVNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B258</accession>
    <name>A0A1Y2B258_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_467941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B258"/>
    <dbReference type="STRING" id="71784.A0A1Y2B258"/>
    <dbReference type="InParanoid" id="A0A1Y2B258"/>
    <dbReference type="OrthoDB" id="2594416at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013390791" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="196"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="270" mass="29292" checksum="6377550F42653818" modified="2017-08-30" version="1">MFHRSTALAALALTFFSLDTVRATPTQTQIQACSQSISLDNYQDTVTYSTSDSTAHNQSYSYSVSACTTPGVKVTSIYTQDLDSNTIYTCTLKQFDTTGTLFTTCSITNGAIATTAQSSGDQDWGDFLKVGQKPTFYTIENDYTVDYYTAPTASAASRKRRALQDEPGLEARSDLSPRINCPAGFSSCWTGVRDQFECINTSSDVESCGACPRSSDAQDCTSIAGSNEVQCFASMCKVISCDSYHTLSADGTSCEPNGRHKKRSIYATRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2Q6</accession>
    <name>A0A1Y2B2Q6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-requiring protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_495851</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2Q6"/>
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    <dbReference type="InParanoid" id="A0A1Y2B2Q6"/>
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    <dbReference type="UniPathway" id="UPA00068"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:L-arginine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
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    </dbReference>
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        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
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    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
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    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
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    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="409"/>
            <end position="599"/>
        </location>
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            <begin position="69"/>
            <end position="92"/>
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            <begin position="83"/>
            <end position="92"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00002294"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00004173"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00008694"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00030322"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY29014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="625" mass="68638" checksum="588957CBA035D6D5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B478</accession>
    <name>A0A1Y2B478_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_532011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AtrR-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
            <end position="882"/>
        </location>
    </feature>
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            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
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            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1067" mass="114810" checksum="CCAAA8E410C32A94" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4I7</accession>
    <name>A0A1Y2B4I7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4I7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4I7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="502" mass="56342" checksum="2990C18B950C2D44" modified="2017-08-30" version="1">MDYNSINFIRPQESSQGNFYSMRSGPMISTSHLRGTPSQQPSLSAQPPPTNHTLTCYSHPPRLRRRVLHGHGMEQIASSEPTSRWQSSDHHSWVYYQQHYQQHYQQQIPSNQASQDRMSQAHPESSYRQSPYQASEYPESCPQADIPDPNGANRFNQYPEQDQTSAALQSIPQSSGDLTDFACQQQAEGEVPMDYQVGQEPPFQSSQFHESWYQDASSSGQNLESEAQQAGLDHWIQPDQVTHASNSLNPNPFWEASSQYSDTRTGQRLQAQPLQDQYAIGTLPMQAPQRLLTVEQGIPQEFLPPVSLELSTWPPRNLPTFAQHGNSSSLSSVEQALHYDSPLVRTDHWNTRMDGPSRSDTGIKEDDPAQPSSYMFSEDVLPRFLGSGEDSTSSLGGDWQQGSRRWADNRALEVSGQGRQSKLRLTKTSMVHPTGPPPRRPGRRAALETALSTVIGQPRTRGRKIRERGDSSLSTRGQAAEKTLYRLTIHAPHARAWVKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4P3</accession>
    <name>A0A1Y2B4P3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_531944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4P3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4P3"/>
    <dbReference type="InParanoid" id="A0A1Y2B4P3"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="78"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY29520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="550" mass="60329" checksum="7AB7C70A67E5E20B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4W0</accession>
    <name>A0A1Y2B4W0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_532712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4W0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4W0"/>
    <dbReference type="InParanoid" id="A0A1Y2B4W0"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58062" checksum="13F04A04B1D697D0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4W4</accession>
    <name>A0A1Y2B4W4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_530828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4W4"/>
    <dbReference type="InParanoid" id="A0A1Y2B4W4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY29746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="71" mass="7930" checksum="AE559B6072BCF9A6" modified="2017-08-30" version="1">MSWTSSTSCFPTSKVTTALDPMTPMTTFTVSTILAPVFASHMISTLHFGCQRSTLAIRSLSRRRWICSVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B501</accession>
    <name>A0A1Y2B501_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B501"/>
    <dbReference type="InParanoid" id="A0A1Y2B501"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="202" mass="21512" checksum="20D1EC28BFD8D0FF" modified="2017-08-30" version="1">MVYPTKLVVRPTTPVQPAIQITPHKPPQDSQAALMNYIPLHATALVPSPRPSSGPAHPAPGPLVLIPKTSGSRARKIFPAGQTTNTPVISYHTQADPSTPYLIQSDTPTTFSRALLAVPHLSPSSSSGSSLHPGLHFGDGSFACLATIMDLPRPVALARTDQDQCYTLNEISSGQKLDLIWAVLRDTSRLTSIHTDLSKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5D3</accession>
    <name>A0A1Y2B5D3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_530762</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5D3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5D3"/>
    <dbReference type="InParanoid" id="A0A1Y2B5D3"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="847"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="859"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="578"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY30039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="896" mass="99298" checksum="49F17C1B150F900A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B662</accession>
    <name>A0A1Y2B662_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_529202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B662"/>
    <dbReference type="InParanoid" id="A0A1Y2B662"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="802"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1183"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="728"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1344" mass="148698" checksum="D513581457C2B613" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B686</accession>
    <name>A0A1Y2B686_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone acetyltransferases subunit 3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_587901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B686"/>
    <dbReference type="FunCoup" id="A0A1Y2B686">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B686"/>
    <dbReference type="InParanoid" id="A0A1Y2B686"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="593" mass="64932" checksum="F2E0E5F11758E87B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6M2</accession>
    <name>A0A1Y2B6M2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_161498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6M2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6M2"/>
    <dbReference type="InParanoid" id="A0A1Y2B6M2"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="407" mass="43630" checksum="262A2E41222E44FF" modified="2017-08-30" version="1">MNSSLSPFSGSPSSIKNETIIDNTAMPRVVPSMAKPPSKSKPRKRVNTAEKRHQHNAIERQRRETLNGKFLSLARLLPALASHRRPSKSAIVNGSISHLTHQRDQRLMAARLLRKMCAEHDELLNEVNEWRKANGFPAKESAPAWTDEVEDVCSVEKEVFGNFASMGGDDDGDDDGADAEADAGEVSLDLNTMQFNGLVTPRSSTQLDSMVQPQDMFADKRQAGVNGLNWSTDFAFNVANGGNASVSSTNSLPFNGFLGSSDGASSTSPANSHSGPVLTPPTTADLGIYTHTPSPRSSAAGEEINKPAPTQSWSAQQLLFMQSNALGQRPNQAPVTFPTQVNPASNPAYGLFAHTAHQAQLQGLNQPAFGTDAFTQSLLSSMFPTNSGSAAQVQEWRKVALAGVEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6X6</accession>
    <name>A0A1Y2B6X6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_558583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6X6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6X6"/>
    <dbReference type="InParanoid" id="A0A1Y2B6X6"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="585"/>
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    </feature>
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            <end position="1143"/>
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            <end position="1268"/>
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            <begin position="334"/>
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            <begin position="359"/>
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            <begin position="375"/>
            <end position="385"/>
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            <begin position="415"/>
            <end position="432"/>
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            <begin position="615"/>
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            <end position="1268"/>
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            <position position="77"/>
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        <ligand>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
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            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY30591.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1268" mass="138995" checksum="0BC192E7BB1FD4C5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B858</accession>
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            <fullName evidence="3">DUF7721 domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Naematelia</taxon>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
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                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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            <dbReference type="Pfam" id="PF24845"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y2B8N5_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">68-887.2</strain>
        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY31066.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="88" mass="9655" checksum="F07463E68E667187" modified="2017-08-30" version="1">MPDLAAWRLYPESSQGRASYWITSGNDPPMFVSSACSGPTGLDALITFANQPTSLLTVQRRRMTVCFHRLLLLLIGYLITVGGEVAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
                <person name="Haridas S."/>
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                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2B8X7"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="494" mass="53731" checksum="39B8569629EF9B7A" modified="2017-08-30" version="1">MASMTTRPYRTHHDMHVAPLVASHMPTFAAPPRATADIPLPEHRTIPKEERRVRYAGAEHTLGPTFSDEEDGDDSAYIASQMAALGLDQLSALAPYGLHGSERNTAVDPRPSDRARGPVDAQAQARIQRQLQLQQLAQQQQQALLLQTILANQPRSGQQASQHQLRESLALLELQQAQQASTYPQLQAHLAAQAQQAQRAVFAAQMQQQQQHQLYLQQLRQQQLDLFTNSQQSYSSPSEQRTILAAQVQASLLARTNRARGMNPDDAELRARFESAPNSNDMYKTPQEPSKPVFEQRLSPYAQPAPSTSWRPSQPAAPPAKSANSDSRPAMGRFAQARQAMANDPKPMGSLSSVLTRRRMTDESSASSQSSSTSERKASDSSQTSPTTSFEEQVRAAPVKNLGLGRPSAPGSGVRSATSPTVLTPRTEPAPRAASYTNGQVARTAVVRQPIGPPGDAKELGDKNFQSRIRRQAGLNLGMLGRRTDAASSTPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B904</accession>
    <name>A0A1Y2B904_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_111608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B904"/>
    <dbReference type="STRING" id="71784.A0A1Y2B904"/>
    <dbReference type="InParanoid" id="A0A1Y2B904"/>
    <dbReference type="OrthoDB" id="2596881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14691">
        <property type="entry name" value="bZIP_XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="422" mass="46669" checksum="B53AFD9FF90F3C9E" modified="2017-08-30" version="1">MTSSSSHSDYGVHPDGEYDGEHDGQVDGEHDGEVDGEVDGEVDGEIDGKVDGEDSSRRHRSLKSVDSAVDGESTSHRDRPTKKQRQRSHSSPELFSPSDINTRTSQAVPLFRSPTTSYTPHGTSQAPLPSGSAGGTSTRASHGEDSLTLRRREANRLAAQRFRSRKKGYQDSLEERVRQLEEERDALLGRLGEPPIGASSLGPRPEEDSRGITPFSVAGTSALLRASPRQSSFSSHSTSPERRESVLTLDLEIRLAALESANRKLQDEAKNASEENERLRFELDRWVHWERDTREGRSRWASDSRQEAKSHDGPSSALPPPDPYLSSSRLPFAKVQEARPPTHHAPSFSQVPFEAAERVPIRLPPLRLAPPPSPISDGVPHRRTSLSLTLPRPPELDHHSSTPQDHARYYQRGKKEDGGSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B916</accession>
    <name>A0A1Y2B916_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_527572</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B916"/>
    <dbReference type="FunCoup" id="A0A1Y2B916">
        <property type="interactions" value="782"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B916"/>
    <dbReference type="InParanoid" id="A0A1Y2B916"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000010">
        <property type="entry name" value="Tryptophan-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY31000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="602" mass="66888" checksum="3520891FBCF3C89A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B968</accession>
    <name>A0A1Y2B968_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_527029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B968"/>
    <dbReference type="STRING" id="71784.A0A1Y2B968"/>
    <dbReference type="InParanoid" id="A0A1Y2B968"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="201" mass="22682" checksum="9505730C0C310B5A" modified="2017-08-30" version="1">MLGFSSLSLGRAVASTSLAAGIRDIFPNASTFQNQIRTSTKRGGGSSKNNRKTAGKRLGVKRFENTFVVPGEVIVRQRGLKFHPGQNVGVARDHTLFAREPGYLKFYQHPTRYPHQDRSVFIDEMNGQTPSAGKSSKDFAMVQFPRGMDRYIGIARFRHETLPRDQRDQGRDRRFWGVPKNTEWHVSEDSKDHGSSETDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9U6</accession>
    <name>A0A1Y2B9U6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AAA domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_96948</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9U6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9U6"/>
    <dbReference type="InParanoid" id="A0A1Y2B9U6"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="15">
        <location>
            <begin position="34"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY31280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="247" mass="27919" checksum="5F090C462AA433A6" modified="2017-08-30" version="1">MIPLVMGCKQAVLVGDHQQLGPVIMNKKAARAGLSQSLFERLVILGNRPIRLQVQYRMHPCLSEFPSNMFYEGTLQNGVTAPERLRKNVDFPWPVSDTPMFFHQNLGTEEISSSGTSFLNRTEASNVEKMVTKFFRSGVLPSQIGVITPYEGQRSYIATYMQLHGSLKKDFYKEVEVASVDAFQGREKDYIILSCVRSNEHQGIGFLNDPRRLNVALTRAKYGVVILGNPKVLSKVSDWAMRWTRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA64</accession>
    <name>A0A1Y2BA64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_526566</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA64"/>
    <dbReference type="FunCoup" id="A0A1Y2BA64">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BA64"/>
    <dbReference type="InParanoid" id="A0A1Y2BA64"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="177" mass="20053" checksum="8FD792004E04E8DC" modified="2017-08-30" version="1">MGRFTGRRVDQAYFAFFIIHLIASLALDLQRSYPAWLIDDTQLAAFKKWYISWSRDPVMLNAYSGDPAWLWIEPFFFLELVFQVPSFVVGAIGLWKNDKRVYPLMLAYAASTATTMLPTVQSLYTAPSNPPLSSAELYNLFASYLPFLIVTLGMAVDMTVRLTHLVGDAQRNKVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAX1</accession>
    <name>A0A1Y2BAX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_524525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAX1"/>
    <dbReference type="FunCoup" id="A0A1Y2BAX1">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAX1"/>
    <dbReference type="InParanoid" id="A0A1Y2BAX1"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001669">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000009">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="47"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="567"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="673"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY31914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="790" mass="88572" checksum="44CB2C4E666357CC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAX4</accession>
    <name>A0A1Y2BAX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_504567</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAX4"/>
    <dbReference type="InParanoid" id="A0A1Y2BAX4"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="HisK_dim/P_dom"/>
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        <property type="entry name" value="PAS_2"/>
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        <property type="entry name" value="Phyto_chromo_attachment"/>
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        <property type="entry name" value="Phytochrome_cen-reg"/>
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        <property type="entry name" value="Phytochrome_PHY_sf"/>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
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        <property type="entry name" value="Response_reg"/>
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        <property type="entry name" value="BCTRLSENSOR"/>
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        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
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        <property type="entry name" value="CheY-like"/>
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    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
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        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
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        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="983"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="1377"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1715"/>
            <end position="1844"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="450"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="562"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="721"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="796"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="928"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1606"/>
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        <location>
            <begin position="1"/>
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    </feature>
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            <begin position="29"/>
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            <begin position="82"/>
            <end position="93"/>
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    </feature>
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            <begin position="94"/>
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        <location>
            <begin position="124"/>
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            <begin position="139"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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        <location>
            <begin position="279"/>
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            <begin position="298"/>
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            <begin position="314"/>
            <end position="333"/>
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            <begin position="495"/>
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            <begin position="1622"/>
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            <position position="1765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022543"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY31988.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1883" mass="204835" checksum="F3538606875FF60B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBH2</accession>
    <name>A0A1Y2BBH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_524508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
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        <property type="protein sequence ID" value="ORY32188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="1905920at2759"/>
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        <property type="reaction ID" value="UER00863"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="HMGL"/>
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        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="414"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY32188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="454" mass="48782" checksum="B576F2FFD3EE6A06" modified="2017-08-30" version="1">MSLVWTSLLPGHSCTLPREGLQAFQAGGAVSRFRSLPSLHSRSFHHDSVCTAGYKTKHPVTAINQHPLIPLHALRASERSMSVSANDGVLNGKHPDPRELPSGRFIRVVEVSARDGLQNLPTPAVPTEVKRELVSRLLDAGVRNIEVGSFVRSDWVPQMADTEQLLRILPPLSGSVKPLDSVPLPPTSNEPSSDPAIEAMTVHYPVLVPNMRGMDNLLKLEESWRNTGAKNSLTDEIAVFVSATEAFSQANNHASVEKVLAGLPAVIDKAGLHGYRVRGYVSCVITCPYSGPTPPEQVVDVAKRLLDMGCYEVSLGDTTGEGNPHAWATLWSALETADLPMPAMAAHCHDTFSMALSSLISLLPRGLATVDASLAGLGGCPYSPGATGNVPTEDVVYALHKLGYRTGIDLDRLVEAGNWLSETLRVRNESRVGRAIWARRVAKQSSTASPGLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBL5</accession>
    <name>A0A1Y2BBL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_523342</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBL5"/>
    <dbReference type="FunCoup" id="A0A1Y2BBL5">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBL5"/>
    <dbReference type="InParanoid" id="A0A1Y2BBL5"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="59"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY32219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="469" mass="50603" checksum="6C5ACEDF78B04815" modified="2017-08-30" version="1">MIRAPARSLVGAAKASTSSSLRRTSVRGLSVVRIATRPALGRIILPAPRTFHASAFQLAETVKVPQMAESITEGTLKQWNKGVGDFVQQDEEIATIETDKIDVSVNAPISGKIVELLAEEDSTVAVGQDLLRIEPGEGESTSKDEAPKEAPEGAARSEPKAPESGNKDEAAPEAGKEKGASKETHKKHDEKAPGMKSSSEEKPAPKKEEAPKPAPKKESAPKEEKKPESHKSVNSRNETRVKMSRMRQTIATRLKASQNAAASLTTFNEIDMSSIMDFRKLYKDGILKNEGVKLGYMSAFSRASVLALKEIPAANASIEGDAIVYRDYVDLSVAVATPKGLVTPVVRNAESLGLLEIEKAIAELGKKARDNKLGLEDMTGGTFTISNGGVFGSLYGTPIINLPQAAVLGMHSIKEKPVVVNGQIVIRPIMVVALTYDHRLLDGREATTFLVRIKEYIEDPRRMLLPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBT3</accession>
    <name>A0A1Y2BBT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_523788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBT3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBT3"/>
    <dbReference type="InParanoid" id="A0A1Y2BBT3"/>
    <dbReference type="OrthoDB" id="428768at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="132" mass="14102" checksum="FEB142EAC488D0F2" modified="2017-08-30" version="1">MVHTGQCLCGAVQIKVDTTEEKQIACHCTDCQHTSGSAHSTNILPKITQVELTGDVKEYNSTAASGNTVTRLFCGTCGSALAHKSKAFGDAMAVQTGNLPDFRKIPFAAELFIKDRWTGIPEIPGSDQAQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCP4</accession>
    <name>A0A1Y2BCP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_379536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCP4"/>
    <dbReference type="InParanoid" id="A0A1Y2BCP4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="288" mass="32313" checksum="F98777D63D78DFE3" modified="2017-08-30" version="1">MTFDLLHLWSDPLLCEQDVSREITPASLYLAPTRTVDALRPRATQQETNLPSTTVVWIGLAFVGTAASFLGILIANRVIRTQARVRRAQARGEEITFRDLWRLDGGMWGFFTGLGGDRLATSMGMNPDLAGIRRMEEMLRMRLWQLDAVDAGLKRPEMCEVEVDSTPQDFFQPLSITCQAVAKDENGRPTRSPIMDMSFLILLPSPAKPESDQYEDLPDLAIGTTIIHPHVNAPHQDIEESFLHNSSEAKQDLINDVQIEYASEGGDHRRQAGWIKIDDVQWAIEGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCV8</accession>
    <name>A0A1Y2BCV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BCR39DRAFT_379364</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCV8"/>
    <dbReference type="FunCoup" id="A0A1Y2BCV8">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCV8"/>
    <dbReference type="InParanoid" id="A0A1Y2BCV8"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012892281" description="alpha-amylase" evidence="17">
        <location>
            <begin position="21"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="33"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="57"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORY32604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="560" mass="60824" checksum="2B1C3B84B7148314" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDG7</accession>
    <name>A0A1Y2BDG7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Abscisic acid G-protein coupled receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_522216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDG7"/>
    <dbReference type="InParanoid" id="A0A1Y2BDG7"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="369"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="495"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="742" mass="79991" checksum="429D8932C7CD53B3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEI5</accession>
    <name>A0A1Y2BEI5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_504199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEI5"/>
    <dbReference type="InParanoid" id="A0A1Y2BEI5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="301" mass="33326" checksum="B75C0000160E6D3E" modified="2017-08-30" version="1">MTSSPQNTDCTLVSSTSPTLPEQYSDLVSNNDPPSTLDPSLALTIPTDTPATYEPSYPSVLHSGKSDGIGNDNDQNDTQETDARSESAPQLDIVFGSTADTQEFVRLWMGLDNETDHDPATKETLRVATKIVEDNDESFLRVQDRVYAAPRLAEWVLCLSEVDKLYRADEFSEEDWFERATLANLRVRDTESDNGFLLSPGWLSRKTDTEEERSEAIRKASQSAFKLLVKRPAGAKAKQEFFSVTTEQMKDIITTVISKLDQLAKTRKAKEERQTETVADGERDIDTGTGADTDGVEGTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEJ3</accession>
    <name>A0A1Y2BEJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_583326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEJ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BEJ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BEJ3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="464" mass="50599" checksum="55289C5A6D9140CB" modified="2017-08-30" version="1">MSETQTTLSPIDGSAIITRKIPTASELDQVLEVSAQAFKSYRVLPLSERIAITSKFLGELERRRDELAVQLTEQMGRPTKGCWNEVGTAIKRGNYLISIAESSLGDVTLKESDTSDHIRLIKREPVGPVMVISPWNYPYLCQINGVVAALLAGNTVLLKPSPQTPLAAEAFESAYLAAGLPKGVLQVLHITPDLVNRAIADRRVKYVVFTGSVANGHAVTKAASESFKGLTLELGGKDPAYVRPDVDLDNAVEWLVDGAFYNCGQSCCAVERIYVHRSISDQFIEKYVDLVKKYKLGDPREADITLGPVVSLKSAETIRKQLADAERAGAKLMIPSEHFPNAKEGTTMVAPQVAINCNHSMELMMEETFGPVVGIMTVDSDEEAIRLMNDSPYGLTASVWTKDQQAFLDIVPQLETGMAFMNGCDAPDPALPWSGVKDSGRGISMSKFAFDGFTQVKGVDIRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BET8</accession>
    <name>A0A1Y2BET8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP/chorismate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_520881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BET8"/>
    <dbReference type="FunCoup" id="A0A1Y2BET8">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BET8"/>
    <dbReference type="InParanoid" id="A0A1Y2BET8"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="129" mass="13824" checksum="70102F252EA757EE" modified="2017-08-30" version="1">MPAEYTLTKEAPAPLPGIYSQAVRAGNYVYTSGSVGMTKEGQMVEGTVQDRTRQVILNLDAVLKGSGMSLKNVVKANIYLSNLSRDFGAVNEVWKELMPEPKPARTCVGVAELPAGGTDVEIEFVAFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEX6</accession>
    <name>A0A1Y2BEX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_463489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEX6"/>
    <dbReference type="FunCoup" id="A0A1Y2BEX6">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEX6"/>
    <dbReference type="InParanoid" id="A0A1Y2BEX6"/>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012824547" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="715" mass="79589" checksum="614D3DED162B74C7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF50</accession>
    <name>A0A1Y2BF50_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_563961</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF50"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF50"/>
    <dbReference type="InParanoid" id="A0A1Y2BF50"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="551" mass="61584" checksum="EA483D266BEC78DC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG26</accession>
    <name>A0A1Y2BG26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_519092</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG26"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG26"/>
    <dbReference type="InParanoid" id="A0A1Y2BG26"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012440659" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="477" mass="52699" checksum="74D01514C8C1E8BF" modified="2017-08-30" version="1">MMLRALSALACLVPALAGVIDLSLGSTEHVLNSVGHLHFGHPLSASALEVTQYYYDPAAGYARKLCSLKSLGEGEDDTDNFLEAVKECGKGGVVRLPDANYTISRPIIIELEHSTLDVHGWISFTQDVQYWIDNRIEFPFQNQSLAFIIRGHDYTLDGNDKGGINGGGQAWYDYARDFGNKFGRPMSLAIEKSKNVVIKNWSIIQPQFWALITIESENILIKDFYVNATSYNPESASDDKNWLQNTDGTDTYKTHNVTFENFVYQGGDDCIALKPNSTMITARNVSCYGGTGIAFGSIAQYPGVLDIIQDVHLEDIRLYPSSQCLGYQGVYFKSWISQSYGIPPNGGGGGYGYCKNVTVKDVYMEDIMHPIAVDTTLTYLPDVKGGADIPSSTFSWYDIHLSNFTGNGSGNRLVWMDCSKLRPCHGWTFDHIDLKPGKDDHPEISYVCNNFLLDGTEGLNQCHPSNSTLETDNGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGK9</accession>
    <name>A0A1Y2BGK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ER to Golgi transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_451900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGK9"/>
    <dbReference type="FunCoup" id="A0A1Y2BGK9">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGK9"/>
    <dbReference type="InParanoid" id="A0A1Y2BGK9"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="231" mass="25431" checksum="7D4A8FF785CD77D7" modified="2017-08-30" version="1" fragment="single">SSRFSLASPPPSSSSTTKRDSRPAQPPSSLQQQLFSNSTHGGILDRPLNRTRGAEVALGAFAFLLSEVVAYSQSRVDSVTDLERRLSALGYEAGLRILNLILLRNTQALGGKDPRREHRLIPILQFVHTHVYRYLFGKSADGLERSVDGEDEYMIALNQPPLTQHISIPKDMSQLSCEAFTAGIVEGVLDGLDVPARVTAHTVATDQYPQRTVILIKLDPRVMDREEALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHN9</accession>
    <name>A0A1Y2BHN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_577876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHN9"/>
    <dbReference type="InParanoid" id="A0A1Y2BHN9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="300" mass="32745" checksum="44475B2B9BC75ACF" modified="2017-08-30" version="1">MGQSTSSRRSDRTQNDPSAAIESSTAVSIPSSRDLMRALGVDRHTQSVDRSPLHISSVSVTRDNAQSVVYTMTFRIRPIQYGLRTFQPDSDYDLEVTTALWLLASAASHRSVFTKREFESTLRSFSQSLSLEPDAVEWTSMNQTPNKYTIKVVVGGSSPGSSTRATIPELNSNVTAANSVEEESELGDNYPWYAGRGTIRGLLDTETIRMYSADPVVDIGPPRFRSASQTGDETRGTKGGKVPGHTKSPHVTGNELSVGLGQVTDEDYCILVKARVWDIHICIYCRIVNAIVLATPASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIC2</accession>
    <name>A0A1Y2BIC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_563321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIC2"/>
    <dbReference type="InParanoid" id="A0A1Y2BIC2"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="513" mass="57488" checksum="5701A7B3BDB5056E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIG3</accession>
    <name>A0A1Y2BIG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_513447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIG3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIG3"/>
    <dbReference type="InParanoid" id="A0A1Y2BIG3"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="517" mass="56430" checksum="9855BD3550102D7C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIG7</accession>
    <name>A0A1Y2BIG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_556090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIG7"/>
    <dbReference type="FunCoup" id="A0A1Y2BIG7">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIG7"/>
    <dbReference type="InParanoid" id="A0A1Y2BIG7"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="119" mass="13561" checksum="F89B32F8E0C4B6E1" modified="2017-08-30" version="1">MQRPNDPLAQRALFIKNLNFNITGSDLYDLFGRYGPIRQIRLGNDANLKTKGTAYVVYESPDDATEAITHLNGFHLMERYIVVLYHHPSKQQASALAKAELRAREQALAMEKQRLGMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIJ1</accession>
    <name>A0A1Y2BIJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Domain of Kin17 curved DNA-binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_513572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIJ1"/>
    <dbReference type="FunCoup" id="A0A1Y2BIJ1">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIJ1"/>
    <dbReference type="InParanoid" id="A0A1Y2BIJ1"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="351" mass="38485" checksum="9421118D94E28EDD" modified="2017-08-30" version="1">MGKAGAGTPKALANAIKAKGLGRLRWYCQICEKQCRDENGFQAHTRSEPHMRKMMLVGPKAGQTIAEFSRQFQYEFVTLLRTRHQTNRVRANAVYNEYIQDKHHVHMNATRWVTLNGFIMTLGKAGTVKVDEDEKGLWITWVDTSPATLQKQAALQKRDRAEMDGEERERMLLEQQIERARALQAEKGQQVDAGLQKPDGEKIKLSLNLFGNTNTLEPSSSTAGPSGTRSIESSEAGPSKSAAPNEDVKPTISFGSIPSAPSTSSSAPPTTVVNPLKRPAPVNVFKQAKTPKTESDAGTSSQGKKGYMSEAERLMKEDQARKGGGSRPQGYGGFGPTRSTQPGAQRRFVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIL2</accession>
    <name>A0A1Y2BIL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_513688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIL2"/>
    <dbReference type="FunCoup" id="A0A1Y2BIL2">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIL2"/>
    <dbReference type="InParanoid" id="A0A1Y2BIL2"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="74"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="402" mass="43198" checksum="C9D69DADBD2DE2B6" modified="2017-08-30" version="1">MASRNVLTRLSGSTSALRRPLTTSSSAAASKLVSRAALASTPVARVPRSASRFLVGQNEAQKRMASSEEGGSTMTVRDALNSALEEEMLRDETVFIIGEEVARYNGAYKVTKGLLDKFGEDRVIDTPITESGFTGMAVGAALAGLRPVCEFMTWNFAMQSIDQIVNSGGKTYYMSGGNVPCPVVFRGPNGAAAGVGAQHSQDFCAWYGSVPGLKVISPWSAADCKGLLKAAIRDPNPVCFLENELLYGVSFPMTKEEMSEDFVLPIGKAKIEKEGTDVTVVAHSKMVTHSLEAAEILEKENGIKVEVINLRSIRPLDIETIIASVKKTNHLVTVEGGFPAFGVGSEIIAQICESSAFDFLDAPPERVTGADVPTPYAESLEHMAFPDTSIIAKVLKRHLYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIT3</accession>
    <name>A0A1Y2BIT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_121420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIT3"/>
    <dbReference type="InParanoid" id="A0A1Y2BIT3"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="179"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="265" mass="28270" checksum="F85E8CF0236F8903" modified="2017-08-30" version="1">MVKIDSISTSSSQNPTTCSTTLSLIIIPVSPFLLPGLRQSVLHPTVSLESQLFPYDHEPTTIHLGAFLVSSSSLSISAFPSLPSSSSLLPSTSPSPSSPSPSPALLSPSPLSISPFLSSSSSFPLSTSSGSDSSNLSTSSESDSSKLVGSLTLVQSTYPRPLDTLPLDIQAKLARTTRHVQLRKFAVSDSYQGKGIGRALMNAAVKLVTPTPTLFFFNARLDKSGFYKKMGMEILHDEIWIQQSPVHDGRAVECIHMGTVLGYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIU8</accession>
    <name>A0A1Y2BIU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_585669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIU8"/>
    <dbReference type="FunCoup" id="A0A1Y2BIU8">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIU8"/>
    <dbReference type="InParanoid" id="A0A1Y2BIU8"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="178"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="233" mass="25523" checksum="63E6DC0E31E64AA3" modified="2017-08-30" version="1">MSSRGGYGTSPRRDDRRGYERDQRSGGGGRDRSRSPRRDRGDDTRGSGGRGGYDRRERDHRGPSKPYDRPPAASYRGGRGGGRGGGYEGRPTREDDYERPLDRRAIEEGRRRREEERANGVVYTDERDAGRDGDHPNGQRGSRDTPGGSGSAAPRSNGRGLGEDGEDDGGEEGEGGEDDDAMAAMLGFGGFTTTKGKGIGQNAEGAVNVHKQRTWRQYMNRRGGFNRPLEKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIW6</accession>
    <name>A0A1Y2BIW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_585683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIW6"/>
    <dbReference type="InParanoid" id="A0A1Y2BIW6"/>
    <dbReference type="OrthoDB" id="3366178at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="424" mass="45549" checksum="A1FB2269E7BEEBC8" modified="2017-08-30" version="1">MSFLSPTRHGMPTSPTPDQPGGSILLNGPGRPHSSSISSIPSTCPSVSDSAYVPGSTSGSAQYSPTASQSSLMSESALTDISATGSGTSTSTKIRFAPLPQVPPDLKRRSSITLGVLARRNMLQGQGTTGAGAGGMSGTTRVVKMTDAEWEEYKRKFDQNKSGKEAVDLGVLAKQGAKSLWRKVRSSSTSSQSSTTSSNNGPTSPSMGVVGGGPPSSPIRYLNNNGTNNNGFAGRARRGSDLAILEEEESPTSGTSSSALGLDTSKYTRARQDYGAWNPENWKPPHAHVHPQPRLLNEDSGQGQGQELDGDVTPRRRASPPPPPHPSIRQVEEEEEEEEEEEGREGQGEVEEEEDESEGVVEGRKEKEEGKEKETHPPGKFQNIIKTEGDVQAEHERDRREAVLGFDDKRYHLDAQGHWEGHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ99</accession>
    <name>A0A1Y2BJ99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ99"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ99"/>
    <dbReference type="OrthoDB" id="2564643at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="127" mass="13937" checksum="413F26B418DD37CE" modified="2017-08-30" version="1">MDSEQKADKGKSRETALPPLPIPAVKGTIGGIESPRRNQFSPSYIGKGHGRESSISTLRADNSSTPSSSTPTQTPLPLSNTHDPSAENDLDQYQDRPVFRSDPTMKSCFDNLKLDGKDEIKRLFYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJA6</accession>
    <name>A0A1Y2BJA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">40S ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_490447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJA6"/>
    <dbReference type="FunCoup" id="A0A1Y2BJA6">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJA6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJA6"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="194" mass="22322" checksum="A2D9361C5E3D6970" modified="2017-08-30" version="1">MGSAPRKQSKTYKVPKRPYEAARLDAELKLAGEYGLRNKREIWRIQLTLSKIRRAARELLKLDDKDPKRLFEGNALIRRLVRIGVLDDTRMRLDYVLALKTEDFLERRLQTQVFKLGLAKSVHHARVLIRQRHIRVGKQVVNVPSFVVRLDSQKHVDYSLKSPYGGGRPGRVKRKRAKAAAGGGEDEEAEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJH5</accession>
    <name>A0A1Y2BJH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inositol hexakisphosphate-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_585872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJH5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJH5"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14496">
        <property type="entry name" value="PTP_paladin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000127">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="898"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1471" mass="163765" checksum="943F0EBCBEAA7A67" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJS6</accession>
    <name>A0A1Y2BJS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_556518</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJS6"/>
    <dbReference type="FunCoup" id="A0A1Y2BJS6">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJS6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJS6"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY35016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="338" mass="38195" checksum="F1B8CF4B938E4C72" modified="2017-08-30" version="1">MPGTAPSQSPNSKSRASEEKRRLERKSKQATGLTPVKIYLLLYNTAAAVLWAHLLYLLLSFLYTSFVSSALVTPRRPETVLKKLLNQSTRIYLPKVVDDFTTRLSGSYDYKNLGWWTKVTQSLAVLEIVHSATGIVRSPFLTTAMQVASRLWTVWGIVEPVPETHSNPLFTTMLFAWSVTEVIRYSFYALSILNIDVGAINWLRFTTFLPLYPLGASSEAFLSFSTLPPLSTLPYIPDWLSTLSPLSSLIRYLPEGWGRYLMKSRIGRAVIWNLAKAGLKGKKVAAGGVKAWGPIELLRLFLFVAWWPALYVLYVHMLVLRKRYFSKGRTVGHKTKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKM9</accession>
    <name>A0A1Y2BKM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_508784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKM9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKM9"/>
    <dbReference type="InParanoid" id="A0A1Y2BKM9"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010897751" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="491" mass="54790" checksum="9B5BFAE2A1D510DD" modified="2017-08-30" version="1">MRLSTCLLAATVLAVPAWARSTQQTVIPGPVDRLSSLQTGQDYVTVTSAHHPGHKVRIKSHKGWCEENAKSYTGYIDAADGKQLFFYFFESRSKPSEDDVVMWINGGPGGSSAMGLFMEQGPCRIKENPETPYDTYTNPYAWNEKANVFFLDQPVGVGFSHGENGQIITNTLDAAKDVASFIDIFFDTFKEYKGRPFHMTGESYGGRYLPVFASAVYDQNAKLLKQGREPVNLKSVMIGNGGTSLFKLIESSFEFACTKHVDLGRSVLEIGQCIQMAEAVPKCHKMLQKYCLDTSDYTSCRMWSQYCINFWTGTAALAEVNWYNVNQSCSAQEREEDRCLAGSSDVEQYLNLNATRKLLGVDDHIKKFELSSNKVNTDFHAALDFEHQTYYWVAQLLERGIKVLNYVGTLDAACDHIGQSKWMAEMPWTGQAAYLAAATEDWVVDGEVAGTFKTAGDLTLLKVYGAGHLVPTDKPKESLVLLNEWIESTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL98</accession>
    <name>A0A1Y2BL98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="6">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF32</name>
        <name evidence="9" type="ORF">BCR39DRAFT_510670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL98"/>
    <dbReference type="FunCoup" id="A0A1Y2BL98">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL98"/>
    <dbReference type="InParanoid" id="A0A1Y2BL98"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="315"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="759"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="526"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="761"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="859"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="912"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="938"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="949"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112072" checksum="131FA95DD25F5DCE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLC3</accession>
    <name>A0A1Y2BLC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_555714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLC3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLC3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLC3"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="576" mass="63030" checksum="06727E5E202DC3AE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEQ5</accession>
    <name>A0A1Y2AEQ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_601385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000119">
        <property type="protein sequence ID" value="ORY21041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEQ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEQ5"/>
    <dbReference type="InParanoid" id="A0A1Y2AEQ5"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="164" mass="18356" checksum="D9414CD235E1220F" modified="2017-08-30" version="1">MPRLVKVAAAQLSSKTQQWKTSSSSPFTADSGANRNHLTTFFPRYFITDEEELASDFESEVDGTVAQSRNVKAFFERRHELDDVQLGYSEVTEKGRYNAAVHRPCTVEPFDHNPSTTDQLEKRKFLPGNLCFNVFRADSLTETCGGASLIAGQLICNDGRWNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEU8</accession>
    <name>A0A1Y2AEU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative histone lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_554394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000120">
        <property type="protein sequence ID" value="ORY21006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEU8"/>
    <dbReference type="FunCoup" id="A0A1Y2AEU8">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AEU8"/>
    <dbReference type="InParanoid" id="A0A1Y2AEU8"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001194">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY21006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="383" mass="41885" checksum="C04BED8F18FC954A" modified="2017-08-30" version="1">MNVNQKPRGIILSEQVVNQLRPAKVFSDAIVRPKHASSSTEPCQITSVSFDDTGEKCLTCGEDENFVVWDARKGSKSMTFPSQKYGVSLARFTHRSANILHASTKMNDHAIRYHSTHDNKYLSYFKGHTARVLSLQINPTNDTFLSAGDDGTARLWDLRMPSCVGLLNDVGGATVAAFDNTGAVLAVACSDTQTIMLYSAASMDKAPFHYASLIDSVLAQTAQPPPKPIFSSLSFSNDGKYLLVGTSSDAHYILDAFTLQMTHRLVGHQGLERDRHGQKDIQPRRGASGEELSWSADSQWIASGSADSTVYLWRVEGSQTDSSTTIPQFCKPVVTLRSGDTHEATGIRTVAFNPRFAMLAAAGEKLSFWLPAKDEESKIAEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFS7</accession>
    <name>A0A1Y2AFS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_562641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFS7"/>
    <dbReference type="InParanoid" id="A0A1Y2AFS7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="404" mass="44907" checksum="27FC54F357E605A2" modified="2017-08-30" version="1">MATSSTTPNAATGSVASSIQSDTLLASTQPAASLDTVSTYASEIERRTGITQAMQDSIEWKSPEYPSDGRKGLPTELWSMIFTDVATTERGERLADGSANEYRERALGRLRLVCTDWWYHVTFNLSRPRASTYWTGVKKLELSESLDGPDGESLNSRLKLVDKSNRYSAVNLRIGLDYGKTRFPYEDGDFKSVKTLLVDLKEGDNGQRSAFLKYTLPQILVDTGVATRIERICINFSDCGEMDDYDQACSKSLTELFAKCDSLNEFACIYTTMGQAKIKATPPRGTVVSIILTPSESVFMNSMQERLAEYSGGDEDQSRATLTLAWTHRSKYNTQGSLLAKTLQLTGEDDIGDLTEPQMTERLQAKRIEVVGSCSFTGSLPFRLYPYRQQFLPRTSTGWPSEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFU5</accession>
    <name>A0A1Y2AFU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_553553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFU5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFU5"/>
    <dbReference type="InParanoid" id="A0A1Y2AFU5"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY21473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="175" mass="19064" checksum="BED251579C1A9569" modified="2017-08-30" version="1">MTSPPFSIRPAKAEDAAQVSHLIGSTWSKFFAYSVSETDLEEYLSGPLSAPRIQADILDPSMRVLVAVESSGNIVGVAHLVIGQAPTCITLPKPIGLRRLYVDSTHHGSGVAGALVQAVDTLSKKEGFESVWLGAWDQNARGLRFYEKMGWKVVGETTFMVGKSVRRDFVLERSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGE6</accession>
    <name>A0A1Y2AGE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNF01220-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_55583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGE6"/>
    <dbReference type="InParanoid" id="A0A1Y2AGE6"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="516" mass="57698" checksum="5633C829160E66E4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGF6</accession>
    <name>A0A1Y2AGF6_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">Separase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000108">
        <property type="protein sequence ID" value="ORY21586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AGF6"/>
    <dbReference type="InParanoid" id="A0A1Y2AGF6"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
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        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
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            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="292"/>
            <end position="327"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1317"/>
            <end position="1356"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="311"/>
        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="567"/>
            <end position="576"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1550" mass="168038" checksum="6ECDAD56B71000CE" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGQ6</accession>
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        <submittedName>
            <fullName evidence="3">SprT-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_63921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000112">
        <property type="protein sequence ID" value="ORY21367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGQ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AGQ6"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="462"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="694" mass="77735" checksum="4F46E0C8AA510C20" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHQ9</accession>
    <name>A0A1Y2AHQ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_552231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000098">
        <property type="protein sequence ID" value="ORY22133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHQ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHQ9"/>
    <dbReference type="InParanoid" id="A0A1Y2AHQ9"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="287"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY22133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="478" mass="52231" checksum="7FBC22BDF93DE8AF" modified="2017-08-30" version="1">MAFSAGQTKRNRGGTRQGERRGTGGAGSSRDASEEDNDNASDVGSLMSVQAGPNTFNVPPETASPRVAPQPVPGPFIAASPVAVAPATARRLHERRWQELSGAGSQSEDPSGGRDSPTYDGDVESSSTIDGTPIHAVHPHGHAHHARRPSSPTPGSALKVDNMHPAPSSMSPHASQRLPTPKASRAQLADVTTPPVPLPYVRPRDVVVQKSLSLAEPRKSQELPLSAPASPKPEPVIQKMTTLPVELSEDNIRGFVRRAIEGKGQEDGVERWWRTNAPPEGKVVRVYADGVYDLFHFGHALQLRQAKLSFPKVHLLVGVCSDALCEDHKSAPAMTHAERCESVRHCRWADEVLPDAPWVVDQAWLEKHDIDYIAHDELVYPSKTHDDVYAFAKSQGKFWVFQPSPPPRHTHTAISTSDLLERIVRGYRDGFFDSKLEKNGHPELLAADVDWDSSASVERRERRSAAAKKRTHAANIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI19</accession>
    <name>A0A1Y2AI19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_54296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000108">
        <property type="protein sequence ID" value="ORY21595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI19"/>
    <dbReference type="STRING" id="71784.A0A1Y2AI19"/>
    <dbReference type="InParanoid" id="A0A1Y2AI19"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="144"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY21595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="260" mass="29945" checksum="1A0E9F050872CE2D" modified="2017-08-30" version="1">MSHDESEMQSKRRAEVEKLLSKRDAAYEDLLDKTASSQSMALADIKGQLEARYTAQEEMLKGEIASLTEHAESRAAEIRRLQSTVESYKLSNEELNRALTAASAGVEDGETFVNSAKELERSRKQHEIQFAEFDLVKKSLMKDLQNRCEKVVELEMQLDEVREQYKVIARSANSRAQQRKLEFLEHNLDALNSVQKQLVEQNTTLKKEVAVAERKLLGRNERIQNLETLLTESDRRLTAKNKKYEDQLQLFKERLAEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ69</accession>
    <name>A0A1Y2AJ69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_552498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000100">
        <property type="protein sequence ID" value="ORY21985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ69"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ69"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ69"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="135" mass="14596" checksum="F8E050FFFE636F58" modified="2017-08-30" version="1" fragment="single">MDEKLQRALSPSSALSPSSSSALPPSLPSAPAITITSTPSVTTLATKDRELAEVQTQLSTTLAALENSRVSARKQAERVLELEARLARADSEKRLEMGKLEVALALEQARVVGLVEERDLARQRLDKVKTTLFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK75</accession>
    <name>A0A1Y2AK75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">And other transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_562157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000086">
        <property type="protein sequence ID" value="ORY22892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK75"/>
    <dbReference type="STRING" id="71784.A0A1Y2AK75"/>
    <dbReference type="InParanoid" id="A0A1Y2AK75"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="982"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1012"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="630"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY22892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1148" mass="125345" checksum="3788307889A76EC4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKR1</accession>
    <name>A0A1Y2AKR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_487597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKR1"/>
    <dbReference type="InParanoid" id="A0A1Y2AKR1"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="315" mass="34716" checksum="AF229340E8749FFF" modified="2017-08-30" version="1">MAPKLRVLVSSATAYPPSSPITVNSTSPTPIKTDHFDGEISVYIKDYNGDHQGGDGSVYFSSKGRESMTYGIVVRGHFLEEINADDVVFGNVFEKSVKDHLPWGTSIATKFMYFVDPTLEIDIYADKPWALSPTLACMNYLSLGTSKPEGHVVEEDSLPELKILYEGSSSPPDAPSDEKSHVSARRKWLGNAENRKNTTITSDTQVGLEFCNGLLDFNTLSATLPQPFRLQVPLLKYWDGQPVTYVCQKRHEKGESPVGGDRVYFSVAFEIVDEEAKKALEKRGGKASDLAKDATETGEEHASTEAHVENDDDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKS9</accession>
    <name>A0A1Y2AKS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_363589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKS9"/>
    <dbReference type="InParanoid" id="A0A1Y2AKS9"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="229" mass="24665" checksum="2892EA6CF21D2AA5" modified="2017-08-30" version="1">MTVNVVVAGSARGIGFELAKQLSSKPNHVVHTVDRYLSTELEDLIKTSKNVHFSLADITDIDQLQNASGLVPHVDLLLCVAGVLGCRESLLGRPASEEEPAADIMNVFRVNLLGTWNVIAAYQEKLARGAKVMLMSSTRASLQRADSDGDPAYSIAKAGLNMLGRKLAVGLSDRGIDVIMMSPGVVKTEMNGWEGEITPEESVNGILQQLAKDGTSGMFLRYNGEIVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKY6</accession>
    <name>A0A1Y2AKY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_549797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKY6"/>
    <dbReference type="InParanoid" id="A0A1Y2AKY6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="181" mass="19950" checksum="C3F9CCAB8D06C2AA" modified="2017-08-30" version="1">MIDGVEDIEYENDPLIEEVTIKRGVRSPLLTRNRDRRNGQTNTNTNRYSWSQSSSGINTKTRTRSRARTRSGIGGDLVQSMKRGLAPRPSRGSSSLNWSTEFRLRILLGIALLLFFVLGAMWIKRIGKKIGLIGGDGDEVGFKGGDGSGLEKIGMGGKILSMFWHDGGSRMTSRSESEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALT1</accession>
    <name>A0A1Y2ALT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_590981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALT1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALT1"/>
    <dbReference type="InParanoid" id="A0A1Y2ALT1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY23444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="490" mass="52089" checksum="26086D3E4591EAC6" modified="2017-08-30" version="1">MVQPKLFDTIVLGAGWSGAVAARDLAAKGHSVLVLEARDRIGGRAKTWSRGDVKIDVGCSWIHGYKEGNPTRTIAKELGVTAHLPKPAEGVIYGPEGPLSSTAASALRASLSSAQASLKTPHPAPPPSASLASALFSSTSPLFTSSTPKPSSDVQNTSPANPDAVPTDSAPAPPKDLAESFARTLEIGLGLKLEQASLKWAGWESATSFAGSDAAPEGGYEALVKKAFGPVEIKLGEEVVSVKYADGAVQVTTVSGETYRGKTVVCTIPLGVLKQLPEEFFFPSLPPARKETIQGTHVGVLEKLLLHYPKAWWPNADTVGSYTFLPTSSTPNENSSLAEIFSGSSLVCANFAGPSLPNSTPTLLTYLSETPARLLLAHPPEQVAKAYHEFLIKRFKPTSTPPEPTEYALTDWHKDKYAYGATTTPSIVSEDGERSPLDFKELSRPLWDGRLGFAGEHTEMDHRGSVAGAVVSGQREGERVARLLNRLADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM27</accession>
    <name>A0A1Y2AM27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_582802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM27"/>
    <dbReference type="InParanoid" id="A0A1Y2AM27"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="414" mass="45281" checksum="249FB910EEE74871" modified="2017-08-30" version="1">MSASSTNPSSCLNPPSQDTTHPAHTQYRAQSGNQPEETYNVDWDKILKMASSLPPTENSSVSSQLVQDPAFSTGYMQNPLSSNEAADTYGYQYPLQPVGLQGEDWNLQGQTNSAGQPSIFLSPNRTTQSGESDPHAASQYQSMRDFHHSQSDLTNPAGNIESSSPLSCPESRLGLGNAPHAWSHQASMQAVRQGDDTNFARPFNFPQGGWYASTSAGVPDSLTAFAASTVARSSDDHVAAPGLTRSSHRHRGRPRGPNDSYSREISLKCVGEGPKCLVPKSTKVVVPNVHRQKVTDNVLTTLCLWCMEGRATLANSKPLRKGTQLRTGVGAEWEDTETDKSVGILCTCERPGTSFRGRTHLTMKTVRVDDTEEETNREGKVPREKCREGEVTRKKIEIKEQQSTSTTVFQYMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN38</accession>
    <name>A0A1Y2AN38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_548311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN38"/>
    <dbReference type="FunCoup" id="A0A1Y2AN38">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AN38"/>
    <dbReference type="InParanoid" id="A0A1Y2AN38"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="316"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY23932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="640" mass="70657" checksum="93976AF75A1AD9A3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN74</accession>
    <name>A0A1Y2AN74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_548111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN74"/>
    <dbReference type="STRING" id="71784.A0A1Y2AN74"/>
    <dbReference type="InParanoid" id="A0A1Y2AN74"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="856" mass="93287" checksum="B7EAA1925D93B65C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANA6</accession>
    <name>A0A1Y2ANA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">BCR39DRAFT_590765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY23992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANA6"/>
    <dbReference type="InParanoid" id="A0A1Y2ANA6"/>
    <dbReference type="OrthoDB" id="2563847at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="175" mass="19493" checksum="8BC2502FEAC12028" modified="2017-08-30" version="1">MSSPGEMTEADPLDLTSLDSDSLFQALTAVERAIPTLLLHTKPILANLSHPAPLRSVSSRDAVEEEQRGIRAREAVEQYMNLLDKIQFVLRQTVYYLHETRVSPNTLRPPPVDAVPTPFASTLPDASQEPELGLYGRRIEAGTLKEMTEVLRRMKRDDEVQESEQLPPSSDQGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANJ2</accession>
    <name>A0A1Y2ANJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger Mcm10/DnaG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_547670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANJ2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANJ2"/>
    <dbReference type="InParanoid" id="A0A1Y2ANJ2"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="3">
        <location>
            <begin position="487"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="690"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="745" mass="81347" checksum="5E1E301CF07CE5DB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQX6</accession>
    <name>A0A1Y2AQX6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_310308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQX6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQX6"/>
    <dbReference type="InParanoid" id="A0A1Y2AQX6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="380" mass="40177" checksum="14FBDB14B11D19EC" modified="2017-08-30" version="1">MYNGGPSTPTQQSGPLRPYLSSPHTPYISPHHHQLYRSPAMDSFGPPSPSSPYLDSSPASTSYIHHANTSNSSLAPTTRSYMSPHFSQQFDSLSTSSPAHLPAQLPSPVEQQHVVVLDWSPLEGGQGTTLSIKCEVNLPPTPSPSYDGSDESNPGSHGKALRVVFGSQPVQTTVHILSSASHLGGGQICQLTATAPSWATTGGIPTSRGNRVSVYIQVLADNHNVIETVLMGEFAYIAGPSRIPFNSYPSNGSLKRAGESLESHRPSPNQFLHRRVFSNSTVSRMDSPVIEQFSQLGATYHPPPPEHGYSSPYTGASATLPTMPAPPGPAYSPSPGAQPSLMRSTQVSVAAPAPTTYTPSSGGKASLELSNDLASMSKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR40</accession>
    <name>A0A1Y2AR40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_545311</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR40"/>
    <dbReference type="FunCoup" id="A0A1Y2AR40">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AR40"/>
    <dbReference type="InParanoid" id="A0A1Y2AR40"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000031">
        <property type="entry name" value="Chromosome 12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY24946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="588" mass="66718" checksum="8D6226E56A594A03" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARP9</accession>
    <name>A0A1Y2ARP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_545462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARP9"/>
    <dbReference type="FunCoup" id="A0A1Y2ARP9">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARP9"/>
    <dbReference type="InParanoid" id="A0A1Y2ARP9"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="311" mass="34420" checksum="A1481328297F0E34" modified="2017-08-30" version="1">MPRDNQLEAISVKDAAKPSKRKSVPKENEDDSDSGSDSGSDISMLDVDFDFYNFNTDIDQIALKRLLRQTLSNDEDRIDVHPLAELILSEGIRMGAGSSIKTDGEDSDPWGLLAVIDVNRNRSNPAFKPFLDYIRSTLPSISPLRLLLDDSPSPAYSNSPALVFSLRVLNLPVPLIPPLYKMLLSELESADNKEVPKFTHWILWGRGYRLEGTEQGMGLEMTVENTGAGGKKKRKAKRNAVDALPASVGQFPYHPEEEFIDNVAAHIHTYPFKTAAPRDDDSFGVEQFGRLVLINHDNLAQAVQAMEAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS43</accession>
    <name>A0A1Y2AS43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">rRNA-processing arch domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_544443</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS43"/>
    <dbReference type="FunCoup" id="A0A1Y2AS43">
        <property type="interactions" value="818"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS43"/>
    <dbReference type="InParanoid" id="A0A1Y2AS43"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="172"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="407"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY25352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1088" mass="121055" checksum="95BED322A540918A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASC0</accession>
    <name>A0A1Y2ASC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_580246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASC0"/>
    <dbReference type="FunCoup" id="A0A1Y2ASC0">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASC0"/>
    <dbReference type="InParanoid" id="A0A1Y2ASC0"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31171" checksum="43712E0FA069A8FA" modified="2017-08-30" version="1">MSDFRKVALITGCSAPSGLGATLARELHSRGWEVFATARKSSSMTGLATAGINTLELDVASKGSVEQTVHNVFKATDGRLDLLINNAAKAQNHPLLDFEPDAVEEYFAIHVFGPLRLMQAFAKPLIKTKGTVVNIGTISSHGLPWQGIYASSKAAAQVQSDVLRRETAPLGLKVITVELGMVNTTRSRLLSMLSDIPNPPSILYPNFAEITRANIDATGKNVDQAPKAESVAKDIINAVDSGFSGKMWTGKSSSLFRWMFPVIPISWQDWIYGKIMKTDMIKPVNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT20</accession>
    <name>A0A1Y2AT20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_600069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AT20"/>
    <dbReference type="InParanoid" id="A0A1Y2AT20"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="772"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="1340"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1278"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1311"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1476" mass="163068" checksum="226CDB4F95FF036D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATW4</accession>
    <name>A0A1Y2ATW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_590008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATW4"/>
    <dbReference type="InParanoid" id="A0A1Y2ATW4"/>
    <dbReference type="OrthoDB" id="2601820at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="361" mass="40298" checksum="9ACAA2EE49D943A8" modified="2017-08-30" version="1">MVYVCRYVTVDQKFGHPSITMLSSLQPEIWRIIVEHLVRPVPSPSEACSWHELHQNDLAAIMRVNTTMYILAAPLLYDSPTIWDLSRFLYRSPNPSPIQPTKADLLKRVRSLTFSNTEHLTAPVDDDELPIVGQMILRRTLEALSCSSTAPAIIPNIDRIEVRAPPDEASTWWRAFNSWMMDTDIDPLPMTQRAFAALVQALSPRTLETYGSPTGPLVYLCRSTSGRAWSFPAHSMQSIGSRAGPTLISHIPQLNPHIRIVKGTTNRFFVQPAGNRQAVDSFVAELMKSLASAELEKGAVAKVEVVGACWPGAIEDGIDKAEKAEVEEEELEKARGLLDKVLRGEAKDRVRLYKRFEVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATX2</accession>
    <name>A0A1Y2ATX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E1-E2 ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_506861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATX2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATX2"/>
    <dbReference type="InParanoid" id="A0A1Y2ATX2"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="190"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="274"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="826" mass="90523" checksum="6F4D193995DA2D0C" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUD4</accession>
    <name>A0A1Y2AUD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_485074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUD4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUD4"/>
    <dbReference type="InParanoid" id="A0A1Y2AUD4"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30735" checksum="28335133D484E920" modified="2017-08-30" version="1">MTSPNITLYLLRDVPGMPLYFPPHPWKTILALKLLDVPHEVEYVSLDELSHVLPLRMGTAKVVLPALKIAHNNQSEEYIMDSYNIAIWLEENFATRERSLFSPGSHYLSSAVVSARIFARFLENWVDHSLAAALRPCIKSFVSNGSDLLTGTHRDSYRARVGVDVIDEMAKLNKDPTWREAQYERAREQFNLLERLLAEQSERGEIGDFITGSEPRYVDIVFFAFYPFSLPNPSLVLGTWRHSSLPFVGKWLDAMLGSGLIDTGALPADPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV82</accession>
    <name>A0A1Y2AV82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_540905</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV82"/>
    <dbReference type="STRING" id="71784.A0A1Y2AV82"/>
    <dbReference type="InParanoid" id="A0A1Y2AV82"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="272"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="495"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="697"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="658"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY26481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1041" mass="115780" checksum="D86F9D864CF3F7A5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV83</accession>
    <name>A0A1Y2AV83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L16p/L10e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_540837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV83"/>
    <dbReference type="FunCoup" id="A0A1Y2AV83">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AV83"/>
    <dbReference type="InParanoid" id="A0A1Y2AV83"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="261" mass="28570" checksum="9C93AE0502A4FA0B" modified="2017-08-30" version="1">MLQSLFRPSSFSSPLASSSRHVLPSFSVGQQVRFRSNIAPKRTKFRKNMKGMPIRPPTGGSLRGSTLNQGSFGVRILESSRITGAQLTACRDTMKRKLKPVKGCEVIMRVFPHLPVSVKGNEVRMGKGKGANGYWAARVPAGRVLFELQGGDVQEAIARQAISLCQDKLPVKSEFIKHDTPARLGLLVDSSLTKPPSNQPVPALMEWQKINEQGSLNRGVGKWRSMLDRLAERRSKRLAIMGVGGTVELENKSVEAAQASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVU9</accession>
    <name>A0A1Y2AVU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sulfiredoxin</fullName>
            <ecNumber evidence="2">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_540647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfiredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVU9"/>
    <dbReference type="FunCoup" id="A0A1Y2AVU9">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVU9"/>
    <dbReference type="InParanoid" id="A0A1Y2AVU9"/>
    <dbReference type="OrthoDB" id="10023328at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="10">
        <location>
            <begin position="47"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY26584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="146" mass="15941" checksum="2EBCDAB952648B44" modified="2017-08-30" version="1">MAEPSSTSCLPPELQPVDGPATQASATPDPDRPSSSIFSRADNAPVHSVPMRVIHRPLPSELDEDKVQAFMEEMKGGDVFTPIEVVKVKAPLKTDPTKTTQNFYFAMGGCHRYEATKRLGLETIRARIIEVPASQMRVYLGAGSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVV1</accession>
    <name>A0A1Y2AVV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_542311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVV1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVV1"/>
    <dbReference type="InParanoid" id="A0A1Y2AVV1"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="250" mass="26395" checksum="6C2C2A461397414E" modified="2017-08-30" version="1">MFELDGKNAIVTGGSRGIGAAVALALGNAGCNVIVNYTSASSEIKATSIVDEINSTTKGKAYLLQADVGADNIGEIVARAAHLHFANGAVDIIVHNAGVSVDKAMPAVTPQDWAHIMNINARGPFFITQSVEPMLADKAKIIFMSSVSARAGFVDDSLYAGSKAAIEAYIKSWPKEQWARSRKISVNGLAVGPCETDMFAAIPQEYQAGFRENPVAEPTDIANLVLLLCSEKAIWINGSIVNANNAMLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWN0</accession>
    <name>A0A1Y2AWN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_540555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWN0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWN0"/>
    <dbReference type="InParanoid" id="A0A1Y2AWN0"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="36"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="439" mass="48366" checksum="430CA3EB0C2998EB" modified="2017-08-30" version="1">MSISQRGAARLSSSKSSPYPSPSGPYYDPELHPQGVINLSTAENSLLSHKILPILNEQSIKSQHLRYRVTLLRSSTPQLADLLPTYVNYRKPVRPVTRANSVAGPGVGSLLAQLFWAICEPGEGVLLSAPYYHDYERDIVFPAEAKTVLAHVPAHVDPLSPDVIPILKQRIQSSNAEGVPIRCLLLCNPHNPIPRCYPRETIEGYIALAQQFNLHLVVDEVFAYTTLSTDSNPHPTPFISVLSLPIWQDPTAAFLQRLHVLAGPTKDLGCSGLKAGLLVTENADVRTLVERGLLPTPISGATEAALTGLLLDEERLTILLEENRRQCAEAMGLCSRWATYHDLPIVEANAGVYFILDLSPVVTNLGLEQGGLEEVSITSQLMRRMITNKVYINPLALDADPQKYRFRFIYTHVQDTLKLALRRLEAAFGLGSFPEVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWV6</accession>
    <name>A0A1Y2AWV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative peroxisomal sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_246158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWV6"/>
    <dbReference type="FunCoup" id="A0A1Y2AWV6">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWV6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWV6"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="448" mass="48319" checksum="8A6C7836CD965782" modified="2017-08-30" version="1">MGQSASIASHQAVKTGALASRDSSIIIVGGGGTMGSSTALHLARRGYTNVRILDVYENPSLNSAGNDLNKIAGADAVGLFGGASDDAWVAWTTDPVFMPYAHSPGKLELTSIGSAGAKHLREKYDKLISLGRSDIAWLANEDDIRQRAPHLAQADIKGWCGLYCSTGGWVAARDALNSVGYELRRLGVKTAFGTAGTFKELILSDDGKRCIGVKCIDGTEWNADLVVLAAGAWSPVLVDLKGQCTSKCWVYAHIQLTPEEADAMRGIPTMYNDTYGFFMEPHPTLNLLKLCNEFPGYTNLQKVQPFGSPKPITISVPRSHAANPSDTIPTESLDDIKRLVSKCLPHLAGRPLINQAMCWCTDTDDGQWVVCEDPRWKGLVLATGDSGHTFKMLPVVGGQVADLIEGKLSEERRQLWRWRPGVGDPLGTGRGGPPPKDLSQVPGWRHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWY0</accession>
    <name>A0A1Y2AWY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_539102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWY0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWY0"/>
    <dbReference type="InParanoid" id="A0A1Y2AWY0"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764:SF38">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="394" mass="41712" checksum="6124DFFE21758F38" modified="2017-08-30" version="1">MTSTMTAVSLATPFPSKRPAASSSSQSAKRQRLSSVKPVDVEGDEDEEDADPEDLSEEAQAKRARKEARTIRNRESAQRSRNQRKQHLAYLEKRVMELEDENRRLKSGSTPLPSTPAREPSPAHSVLSLANDLGLPTELVSTSGGVNLASVAPPPQGLEVDVKPVVPSSPALTVQPLADTPSYSELLAENGILQERVRLLESLVKNAIALSNLGGSPTTPPQYTETPSNMSTVSNTSSGMVHQGSLDWDNFLKPSTTSLQSTLSPSFHPVQQSANPTPLSLASTNAQINNLTRHPAAGEASFDLSVGDAFQSQGGGFGGEGGSDSGKGQGLAFAFYDSGLASQSLSVYENTGEEMNLWGSMPEETWGGAAVGKEDSLGLEWWSMELGMGSTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXF1</accession>
    <name>A0A1Y2AXF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXF1"/>
    <dbReference type="InParanoid" id="A0A1Y2AXF1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="963" mass="104897" checksum="D72CE3914BDA690C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXT0</accession>
    <name>A0A1Y2AXT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXT0"/>
    <dbReference type="InParanoid" id="A0A1Y2AXT0"/>
    <dbReference type="OrthoDB" id="2502001at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012350040" evidence="1">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="282" mass="31221" checksum="4C1B4C2F3A52E17D" modified="2017-08-30" version="1">MHLLGLLALALTSTSVLAEVTAGSVFDVAKKVVTNALTGKVPSDISYLDTTDEEAKVVRIDDRNASVLNEGNWVILVHAPPRRPLDRAFMQVHSNASLAYHEFSPELSASAETPMEEFHFARIDFMDAVEISTRWMVWRPPKIVIIENQGPNRSIRFISNGNIPLNGTTLFRAIRDETYRQVPTWESNWAPGGDKAWIIDYYLAAMAKWSEKTSRIPNFVWLMLSGYIAKELLGWLHSARGNTQVPTTTTTTTTPLTGSAAAAARAQLRARAAAAKNKPKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY01</accession>
    <name>A0A1Y2AY01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_540136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY01"/>
    <dbReference type="STRING" id="71784.A0A1Y2AY01"/>
    <dbReference type="InParanoid" id="A0A1Y2AY01"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
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        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="556" mass="61889" checksum="6C7CB735269D6986" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYH7</accession>
    <name>A0A1Y2AYH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_506186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <end position="129"/>
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            <begin position="158"/>
            <end position="188"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y2AYI2_9TREE</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BCR39DRAFT_537509</name>
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        <name type="scientific">Naematelia encephala</name>
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        <lineage>
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            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2AYI2"/>
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    <dbReference type="OrthoDB" id="5876637at2759"/>
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    </dbReference>
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        </location>
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            <end position="330"/>
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            <begin position="1"/>
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        </location>
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            <end position="110"/>
        </location>
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            <begin position="111"/>
            <end position="121"/>
        </location>
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            <end position="212"/>
        </location>
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            <begin position="284"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="330" mass="36187" checksum="B88C99325C3F8653" modified="2017-08-30" version="1">MPHKRAKRSVRTAETAKKGSNLAPPQSSTHDDTPSSASRILNSLAARTAFRASGRTSSEDIGGYIPKSKRIKIDSSTSTSTKHLNQVKNSNGSGKINSNNNVTTKVNNTNGLTSKVNNNDNTRGKGGKEREESGTDNRNKVEIKKIMPHETLREYNQRVESTLRPGLNKAMKLARSSDPSKKSKSNSKSKSQPQQDPTSTSTSTSASTSSSSLGKTKEFKPIPGPRRLNDIVQAPPQLPSLRRTGGKGENKGVWSSIGKGGAVLNAGQRRLLEVERERVVSVYREIKERREKEREDERREREEKSKSKGKGKGQGQNKRKISDVDVDVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ61</accession>
    <name>A0A1Y2AZ61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_536993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ61"/>
    <dbReference type="FunCoup" id="A0A1Y2AZ61">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ61"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ61"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="83"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="395"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY27754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="634" mass="69983" checksum="23CF36A94D8FD8AE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZK6</accession>
    <name>A0A1Y2AZK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial outer membrane translocase receptor TOM70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_468703</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZK6"/>
    <dbReference type="FunCoup" id="A0A1Y2AZK6">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZK6"/>
    <dbReference type="InParanoid" id="A0A1Y2AZK6"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY28008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="72098" checksum="30768A66D0AB32D6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0A8</accession>
    <name>A0A1Y2B0A8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-actin-capping protein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_535210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0A8"/>
    <dbReference type="FunCoup" id="A0A1Y2B0A8">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0A8"/>
    <dbReference type="InParanoid" id="A0A1Y2B0A8"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0117">Actin capping</keyword>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="464" mass="50043" checksum="E0E9EE6781A6530A" modified="2017-08-30" version="1">MAELSLEEKCNLASKLVEQAPPGQVNDVINDIRAIIGNDEALMPYIRPALRTYILTQLTVVEHPASGDVPVHTSLLSEATILPGSTAEKERFIDAEGGRSFAFDHINMTISEYEPYELPAEEAAFRAELAKSLAAYCKNHFPSGSSSVSSSQYPLLPPAPPAPVPAPVSEEPVTDVVPEQLNTGDAEPAPTPAVGDVEVKQEEVVAPGGLEKLDEEVEKAKEEEEGTEAASVPESTKPVVEESSEAASVPEATKPEVTEEPGSEEAAKVEEEPAAAAETAKVEDEPTEAGEPAAEAPEVPEPPAQATEAVEPAPPAVEQRKQERIENPTYTLEIVGNRYNTANFWTGRWRTRWVVDQAAGTVSGTINVDVHYYEQGNVQLATNHTSIFPLPTEATGSQSIASQIVTTISKIETTYHLELNDVYGELGDKVFRGLRRALPVTRQKMEWEKVSGYTLGSDLTKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0B0</accession>
    <name>A0A1Y2B0B0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative nuclear mRNA splicing, via spliceosome-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_496571</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0B0"/>
    <dbReference type="FunCoup" id="A0A1Y2B0B0">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0B0"/>
    <dbReference type="InParanoid" id="A0A1Y2B0B0"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000502">
        <property type="entry name" value="Pre-mRNA-splicing factor cwc2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY28174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="353" mass="39369" checksum="5FB410744C70A47A" modified="2017-08-30" version="1">MSDSVVPTKRKLRPARKQVKPGEIDKTEGPQPGKEYNVWYNKWAGGDKEDALASKTLSQSRCVISRDAGYTRADATGNKFCCLFFARGCCPYGHECNFLHRLPLPPSQYPDHSRDCFGREKHSEYRDDMGGVGSFNRSNRTLYIGKIQESPDKHQSQETLLRHFGEWGKIVKWNLLYNRGIGFVTYETEQMASFAKEAMANQSMDMDEVLNVRWATEDPNPEEKVAEAKRIEEVGQKAISGMLDEGLVEAAQTLRALEDGDEEDFYPIEPSKADSPEPEDVRPAKRAREIETESNGGAQKKLAGNGIFSADAMDNLKFYAEMARKQAEQTKSAKPPASGMALLGGYGSGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1A9</accession>
    <name>A0A1Y2B1A9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_535105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1A9"/>
    <dbReference type="InParanoid" id="A0A1Y2B1A9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="83" mass="9986" checksum="6E1E74998B99F01A" modified="2017-08-30" version="1">MLLTTVDIATKLLGRRHRILPEHNDRRLVENRCYKRSRYIVLQNRLRRRSMIPIIGSLQLLFVVLAKNRISPIYNLHNYAYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1S4</accession>
    <name>A0A1Y2B1S4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-glucan synthesis-associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_533712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1S4"/>
    <dbReference type="FunCoup" id="A0A1Y2B1S4">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1S4"/>
    <dbReference type="InParanoid" id="A0A1Y2B1S4"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000259">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="399"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="834" mass="90537" checksum="18C0BF93594F6A93" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B279</accession>
    <name>A0A1Y2B279_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clasp N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_534297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B279"/>
    <dbReference type="STRING" id="71784.A0A1Y2B279"/>
    <dbReference type="InParanoid" id="A0A1Y2B279"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="305"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1181"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1198"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1210" mass="131017" checksum="38D6A780F83E37EB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2G6</accession>
    <name>A0A1Y2B2G6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_183221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2G6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2G6"/>
    <dbReference type="InParanoid" id="A0A1Y2B2G6"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="226"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY29003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="470" mass="49998" checksum="22DA981AA6414193" modified="2017-08-30" version="1">MAEANTEMLEEQLKRGRSGTFSGHLGGAAGSPVTPSNPTRQTPQTSGAAVPRAVTNPTRAATATTSATTTPARKLDETKRPTSLQIPASASNSAQTQNVSSANGKDEGKGWKFWNKQQKLGGVTLPSPAQVMAQIPGTPTSERPFDFSTLMPSAQAAFGLPDAPANPNVRAREIPLQRSSSMQTINGAQRPPGTPSGAATQVSELARLRAAHAAAQTKIETMGKELVELKKGKVDMEAELENLSQALFEEANKMVADERRRRAEIEELLKEVREEREALRSTIKVLGGKVEEEAQAAGEEEETKVDEVKDSEDPDFVPRDLDKHYEALRKTIHHVSDGANTAGGIPDLSMVSNMPVLEEGPHEEDEVEELEDVVGELETPDVSRLAASEPNLLGIGVGNTSLGAELNPWADPFANAASTIIPPGQAALPGEEELRPTRNAFLDEVAPDVAGEGEPPSVVEAFGVKQDVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2X6</accession>
    <name>A0A1Y2B2X6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_533034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2X6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2X6"/>
    <dbReference type="InParanoid" id="A0A1Y2B2X6"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="515" mass="55593" checksum="878B110E8699CEA8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B348</accession>
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        </submittedName>
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        <name evidence="5" type="ORF">BCR39DRAFT_588452</name>
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            <taxon>Naematelia</taxon>
        </lineage>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
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                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="STRING" id="71784.A0A1Y2B348"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="5"/>
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        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="19"/>
        </location>
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            <end position="1071"/>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Protein UNC80 C-terminal domain-containing protein</fullName>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
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                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
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                <person name="Spatafora J.W."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="UNC80_C"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1425"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="204"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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            <begin position="28"/>
            <end position="46"/>
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        <location>
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            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2305" mass="252385" checksum="02B5C8B7B3061EBF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B435</accession>
    <name>A0A1Y2B435_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_531676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B435"/>
    <dbReference type="InParanoid" id="A0A1Y2B435"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="95" mass="10953" checksum="4C0FCD8C83C4B5CF" modified="2017-08-30" version="1">MFRTISLSFHHITTYHTTLPTFLLPPIRYLDRLLMVGNPDPTLSLSLFCLVSSLFSLFAFLSATRLNRSQRHTEERSGSNDSFRFRNVSSAYHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B468</accession>
    <name>A0A1Y2B468_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_593906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B468"/>
    <dbReference type="FunCoup" id="A0A1Y2B468">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B468"/>
    <dbReference type="InParanoid" id="A0A1Y2B468"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="199" mass="22437" checksum="DC96E900D4B18B0E" modified="2017-08-30" version="1">MTTHHERQHPIILITGTPGTGKTLHSTLLAQNHSTSSSSSSSPLTHLNIGDIVKTHGFHEGYDTEWAAWTVDEDRLLDYLEEVVNPQDGPSETGFIIDHHDPSLFPERWIDLAVVLTCDNKVLHERLTERNYPPAKITENITAEIMMTCLTETRESYAQEIIVELPSDGRGGDAEVEDNVRRIGEWVEAWRADRESGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4D4</accession>
    <name>A0A1Y2B4D4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_167824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4D4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4D4"/>
    <dbReference type="InParanoid" id="A0A1Y2B4D4"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="588" mass="62220" checksum="5C62C3790120C714" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4S3</accession>
    <name>A0A1Y2B4S3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_531178</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4S3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4S3"/>
    <dbReference type="InParanoid" id="A0A1Y2B4S3"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY29828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="500" mass="57115" checksum="1C06E81192DB7BC0" modified="2017-08-30" version="1">MSTSETVLNGDAVPQGFKTTSYPAIANPPLPAEGSAAFNNLHMILLNLAVSWLVQKLIPFRTGWTTYFVLLALLFVPVTMSYWILTSKYGRRVNEKIPLPGKPLDHYLEIKGGGLTKYEGKKIPMQVFHDAYFDGKVEFKGEVLDVMEYRHDWATFEFTPELFKYVFTNLIPDVILHTESQDAEQVTDHYDRGNDFYSWFLGPRMIYTSGVISDINRMETLEELQDNKLTLVCEKLDLKPGDKMLDIGCGWGTLATHAAKNYGVDVTGVTLAKEQTAFGNERLQENGIPETQGRILCKDFRNIDHPKGYFNKISCLEMAEHVGIRRYSKFLGEVYDLLDDDGLMVFQVAGIRTNWQFEDLNWGLFMNKYVFPGADASLPLGWVIKQLESANFEIKSVDVLGVHYSATLYRWYLNWVSNKDKVVEKYGIRWYRVWVFFLAYSVIASRQGTASVFQITCHKNLNGFHRIEGVPSHGSIHAPISRKIESVVSHKDLWPEKYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6A4</accession>
    <name>A0A1Y2B6A4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_448293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6A4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6A4"/>
    <dbReference type="InParanoid" id="A0A1Y2B6A4"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="123" mass="13792" checksum="F0EB684DC08A5190" modified="2017-08-30" version="1" fragment="single">KVVLLGSQGVGKTSLILRYTTRVFSTSPAAATIGSSLHTRKLVHSGVRVKLQIWDTAGQERFRSMAPIYYRGAHVCVLVYDISDRQSFQDVRSWLEELARTVPKETVIYVVGAKIDLESRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B835</accession>
    <name>A0A1Y2B835_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_527565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY30998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B835"/>
    <dbReference type="FunCoup" id="A0A1Y2B835">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B835"/>
    <dbReference type="InParanoid" id="A0A1Y2B835"/>
    <dbReference type="OrthoDB" id="3063237at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY30998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="120" mass="13239" checksum="6977EE66DFB708B4" modified="2017-08-30" version="1">MPSATEQTLDNQNEEELDRLHGKIKALRSVTIDILDDSGRQNDQLDRTTNTFSSFTNSLFSTSRHHSRSIASNSTIRQYRMIAYIVGAVVVLWLILRVWTHGGGGGGGPGGYHPEPEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8F8</accession>
    <name>A0A1Y2B8F8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_528264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8F8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8F8"/>
    <dbReference type="InParanoid" id="A0A1Y2B8F8"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY30777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="680" mass="76904" checksum="8E50B1A0EBF4FA95" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8Z3</accession>
    <name>A0A1Y2B8Z3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Chorismate mutase</fullName>
            <ecNumber evidence="4 13">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_527275</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4 13"/>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8Z3"/>
    <dbReference type="FunCoup" id="A0A1Y2B8Z3">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8Z3"/>
    <dbReference type="InParanoid" id="A0A1Y2B8Z3"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY31289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="32228" checksum="5CCF517B7B745B7B" modified="2017-08-30" version="1">MNFTSGEDASQLLSLDRIRGQLIRLEDTIIFSLIERAQFGLNEKIYQAGAFKDELDSQGSWLEWFLYEIESFHAKARRYTSPDEHSFTPLEKLPKPVIGLQAYPTLLHDPAARHPSVNVNSKILDFYVKHIVPGITPPLDDGNYGSAATRDVEVLQALSRRIHFGMFVSESKFLSAPQDFIPHILSNPPNTEALAGLITKPEVEAKLLIRLRNKARVYGGEMNADGTVMELSDAELKARGKIDIEQVVGMYRDWVIPLTKDVEVDYLIHRLDGVPRSQIDAWLGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B998</accession>
    <name>A0A1Y2B998_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_526784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B998"/>
    <dbReference type="FunCoup" id="A0A1Y2B998">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2B998"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY31441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="632" mass="68465" checksum="85C3A08EB20F2376" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9F0</accession>
    <name>A0A1Y2B9F0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thaumatin family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_587484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9F0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9F0"/>
    <dbReference type="InParanoid" id="A0A1Y2B9F0"/>
    <dbReference type="OrthoDB" id="3342934at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="33657" checksum="DED34DA6EB07CE99" modified="2017-08-30" version="1">MGIAAGVSPLTNADTRTATKLDAYDAKDLYNLAGSSLTVTKSDREGKPALALTRSGKEASSDLTWASISSHPSRTIDLQRKETHKVLTLNMVRYRQDGCHGDHAPSTFLSYQLQVPSTCLSYQLSLYNLHYKLLSTQPEDFEMFTNLISLFAVLGAVSAAVVNPVARQSESHTVTLINNCGSGQARFLYQGNSNPQGSATIIGPLDGGVAWVDGFAGANCLSSGVNCGVVEFTLVNPSGANPPQNAVDYSLQTQGNHQYTYEMNAAYTNSASCAGRGPPGPCTGPTQASCPGAFVGSDTTDGTVYQCIDSNVGITITFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9W8</accession>
    <name>A0A1Y2B9W8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_571181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9W8"/>
    <dbReference type="FunCoup" id="A0A1Y2B9W8">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9W8"/>
    <dbReference type="InParanoid" id="A0A1Y2B9W8"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="208" mass="23871" checksum="637FD771856494A9" modified="2017-08-30" version="1">MGITRDSRHKRAASGARRAHYRKKRKFELGRQPAMTKLDSSKRIHEVRTRGGNVKYRALRLDSGNFAWGSEHCTRKARLIQVRYNATNNELLRTQTLVKSAIVDVDATPFRQWYEAHYAQPVYRGGKIVDEAAADKKQSNHVKRIVDERKKDAKIDPILEQQFKAGRLLACITSRPGQSGRADGYILEGKELDFYNRKLQVRKAKHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9X4</accession>
    <name>A0A1Y2B9X4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9X4"/>
    <dbReference type="InParanoid" id="A0A1Y2B9X4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="658" mass="73187" checksum="22194E186012CD1F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAC8</accession>
    <name>A0A1Y2BAC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_525500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAC8"/>
    <dbReference type="InParanoid" id="A0A1Y2BAC8"/>
    <dbReference type="OrthoDB" id="549336at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="56748" checksum="59A04A32E9DE0CE3" modified="2017-08-30" version="1" fragment="single">MIRSLSSRRFGLVGTLLIVTLATVLLLWNSEQSLSTRGALSASRNWGSFTGSRVVIEEDDGCIDYSPLALPGLLESAGNGRSLNGLRVAVLEQTGFHDEVIPPLARALQDVGVSYEIYRSRGRWHWIDLLRLVVAYPSEALGVSDKTYENRVSSGEIDVTIHVSCDAKWNPSAGFGAILKNTPSHQLVCLYHNSHDLRDSDRDFWVDMARDGRLQMVTLSPLASDRMRAGILKWGDHQDEVAWQGVQVETILPIFPLDYQQLPDTDRVQAHELVPRERSRRPSRMAIVGGIEPKRRRYTAFIQELHRSVQADSSVWGYKLESGIYVPDPSSAVEPAKFYLVGKLHASFDLNIPSEIASMIEIVSDLEFEEFYLFLASMDLLVPAFGSDDYLNGKLSSVIPISLITQTPILVDERTLRSYSFLRYPAISLRPTGQAEVDSIALLRQGIDPWTSASKYGPPRRIVPAQSAGWDQYVAELMDVNADTMRRILERVVARRDDWNMEGEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBA2</accession>
    <name>A0A1Y2BBA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_525273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBA2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBA2"/>
    <dbReference type="InParanoid" id="A0A1Y2BBA2"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="919" mass="101008" checksum="0C240D134DBE9A10" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBM4</accession>
    <name>A0A1Y2BBM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_41711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBM4"/>
    <dbReference type="FunCoup" id="A0A1Y2BBM4">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBM4"/>
    <dbReference type="InParanoid" id="A0A1Y2BBM4"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="289"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY32229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="422" mass="47908" checksum="7BE2A971A1655658" modified="2017-08-30" version="1">MPSLPDTTHTPFRLCEKHFKNRSLRGVYPTLHGRGVIDLSRPAKQEDDEVWRGGWWSAGMSEEELRRWRKGKGKARERGDREEVNVDELKRIELSDGKVGWVVSEGCIFIPQYLTTSEQLDLLDDCLSNYTLPPNPLSLSTHYALPSNLFTLYATDSTDLIQPLHIFRPPSVIPLPSSRRTVETEPGSVLGYDEIVARNKEWKGDEPSVKLGPKRADELMRDLRWANLGWVYQWSTKSYDFTPDDPIVFPPELAHMCTKVVKSVPWDLVFDQSVEEKQPDWSTWSDDYVPDTGIVNFYQMKDTLMGHVDRAELDPSRPLVSISLGHAAIFLLGSASRNQPPIPIILRSGDVLIMSGNGRQSYHGVPRIMEGTLPAHFQPNDGDEQNRKAAKKFIATARVNVNARQVFPLGFRRPDRHQDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBS3</accession>
    <name>A0A1Y2BBS3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_593120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBS3"/>
    <dbReference type="InParanoid" id="A0A1Y2BBS3"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="57"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="524" mass="58537" checksum="F092D308E9F89A79" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC07</accession>
    <name>A0A1Y2BC07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_523795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC07"/>
    <dbReference type="FunCoup" id="A0A1Y2BC07">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BC07"/>
    <dbReference type="InParanoid" id="A0A1Y2BC07"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="67"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY32294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="183" mass="19666" checksum="B3A8E2EB8AC2F056" modified="2017-08-30" version="1">MSSSGWEVRFSSTRNLPYFFNGSTSTSQWDAPSELSPEQIAKLPGAEKYLSQGAAGTGAVGGAGGKQGQARASHILAKHTGSRRPSSWKQEKITRSKEEARKQIQAHIDHLSTLTESEKNREFAKIASVDSDCSSAKKGGDLGWFGPGQMQKSFEEATFALQPGQMSGLVESDSGVHVIYRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC39</accession>
    <name>A0A1Y2BC39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_564326</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BC39"/>
    <dbReference type="InParanoid" id="A0A1Y2BC39"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000003">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000006">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000235">
        <property type="entry name" value="Probable nik-1 protein (Os-1p protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="197"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="290"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="382"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="474"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="566"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="658"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="751"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="825"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1221"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1364" mass="147417" checksum="5A40827CCA510592" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCD6</accession>
    <name>A0A1Y2BCD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_522503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORY32498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BCD6"/>
    <dbReference type="InParanoid" id="A0A1Y2BCD6"/>
    <dbReference type="OrthoDB" id="3263880at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="82632" checksum="8509160E98685A09" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCF1</accession>
    <name>A0A1Y2BCF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BCR39DRAFT_522595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2BCF1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013231593" evidence="1">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="67" mass="7350" checksum="3B89F5DD849741DB" modified="2017-08-30" version="1">MEVFGSVVVLAALLGFAAIMANREDHVIKAHRSLLENATLITPEKLDLVLAELKLLRQAVDRIGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDX7</accession>
    <name>A0A1Y2BDX7_9TREE</name>
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        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">BCR39DRAFT_464016</name>
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    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y2BDX7">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDX7"/>
    <dbReference type="InParanoid" id="A0A1Y2BDX7"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="498"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="704"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="385"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="437"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="934"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127868" checksum="27094FE9D80E7869" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDZ8</accession>
    <name>A0A1Y2BDZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_523798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDZ8"/>
    <dbReference type="InParanoid" id="A0A1Y2BDZ8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="187" mass="18283" checksum="FC7A022DD14F2489" modified="2017-08-30" version="1">MSMLTPSKQQRHITVSSAASASRTFNPSTTHPASLSSKTSPSPFSTSGQKRIHVTSSSSASGDVPPEGAISGGGGGGGSGAGSIEGIEGPNRKNGSDQEGDEKESGEGKESEGGEGEGKGNGNGKGEGYGDVTRWHPASSEGKSISSGDEEGTKSGGEKNQDGTGGVAGGMGVRGGLGGSSVEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE37</accession>
    <name>A0A1Y2BE37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Origin recognition complex subunit 3 winged helix C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_521705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE37"/>
    <dbReference type="STRING" id="71784.A0A1Y2BE37"/>
    <dbReference type="InParanoid" id="A0A1Y2BE37"/>
    <dbReference type="OrthoDB" id="2573365at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="2">
        <location>
            <begin position="351"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="560" mass="61532" checksum="F001DC0C6E0E6CB4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE69</accession>
    <name>A0A1Y2BE69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_521394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE69"/>
    <dbReference type="FunCoup" id="A0A1Y2BE69">
        <property type="interactions" value="825"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE69"/>
    <dbReference type="InParanoid" id="A0A1Y2BE69"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="259" mass="27955" checksum="91F58A9023ED90B8" modified="2017-08-30" version="1">MRLTPEFVSKAPSHLNPLKERELDLRGLQIPVIENLAAHQGGYDTLNLNDNSLTVLSNIPQTTRLTSLHAAQNQISSIAPSLPQSIPNLITLVLTENAITSLATLVPLGDLVNLRHLSLKGNPVSAHEHYREFVIWKVAKGKLHTLDFTRIKDAERESARKKFTDPLTNLPNALAHQLSIPTTSSVPGASFAASTKSGATGKGGKGRLMTPDEKRRVVEALTRANTADEVRKLERMLADGLVPEGGMDISTNGEAVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEB5</accession>
    <name>A0A1Y2BEB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_582094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEB5"/>
    <dbReference type="FunCoup" id="A0A1Y2BEB5">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEB5"/>
    <dbReference type="InParanoid" id="A0A1Y2BEB5"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="225"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="42818" checksum="76DE9C34BCEA6C9A" modified="2017-08-30" version="1">MPLVTEFVSAALEADPSLAGSSDKDKSAISLLDSETVSLAKDLSALNTRLTPITYLYHNTPSTADISLYCRLHPTLTKLSTPASQHPSNPSVLRYFLQIQSLDPVIAARKSHPNSFPLLEIDVSSLPAPPREVIAPVKKEKKDKKAAPAPEPAKEASGIVASATAAVEAVASAAIGVKEAVIGGASEKEASVPKEGKAGKDGKKKEKKEKPAKAPVVKEEPTGPLPSMIDMRVGKVLDVKKHPEADSLYVEQIDIGEAEPRTVCSGLVKYMKEEDILGQTIIVICNLKPVTMRGVKSYAMLLCASQSSGTGEKEGVEFVFPPAGSVPGERIYFEGEKYENQVPEPQLNPKKKVFESIQPGFITLDNLDAAWIDPITKSVHKIRTEDGICKAKSFVGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF60</accession>
    <name>A0A1Y2BF60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_521278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF60"/>
    <dbReference type="FunCoup" id="A0A1Y2BF60">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF60"/>
    <dbReference type="InParanoid" id="A0A1Y2BF60"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000001">
        <property type="entry name" value="Translin-associated factor X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="270" mass="30866" checksum="7E49AE36E39649D1" modified="2017-08-30" version="1">MTEVLMPESSSAPSSRREQLATTFEGYRSELDADNERRERLIILSRSTTQLSKKLIFHLHRGATLTSLEARSKNLQEARNKVAEIKINFGKIYDEIRGGINVESYWRWARQVSPGLEEYIEAISFLYYLEHASLIPLSEIQSELSDPTTGQPYVVVTPEDYVLGMSDLTGELMRYATNSLSTGDHEIPLAVCDFVRTVKTYFDGISPAMLYKLSKKQEETTRSLEKIEKVCYALRLRLVEYADRPEILRQMAKRALEDARDREGEGDKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFX9</accession>
    <name>A0A1Y2BFX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_518739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFX9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFX9"/>
    <dbReference type="InParanoid" id="A0A1Y2BFX9"/>
    <dbReference type="OrthoDB" id="2596744at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="955"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1180" mass="125509" checksum="114A6F9F49B103C6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG08</accession>
    <name>A0A1Y2BG08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_520463</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG08"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG08"/>
    <dbReference type="InParanoid" id="A0A1Y2BG08"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="28"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="574"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="745" mass="81379" checksum="C8F0671C6AC212A7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGX0</accession>
    <name>A0A1Y2BGX0_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34059.1"/>
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    <dbReference type="OrthoDB" id="5954308at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Anthrone_oxy"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19071" checksum="4C166771C8B4C3F6" modified="2017-08-30" version="1">MFGLPDSTVVLTGGLISTSYVLFSNLGMSQIGIIPLINGRLGEFHLPARERAKAWSLYFKQAAPWTIGPSVVGAGLNFAAAYMTSSPFIRQLAITAGITGLTIVPYTLTFIHGINLQLHAINNEDKLRDVPESHPHAKQVGQLTTDWEKRHWVRFVAYGGAFALNLAALLAQQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHC0</accession>
    <name>A0A1Y2BHC0_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHC0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHC0"/>
    <dbReference type="InParanoid" id="A0A1Y2BHC0"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
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        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="585" mass="66147" checksum="5F11F2CEE6F9C360" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHL9</accession>
    <name>A0A1Y2BHL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor IIIC subunit delta N-term-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_518139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHL9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHL9"/>
    <dbReference type="InParanoid" id="A0A1Y2BHL9"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="3">
        <location>
            <begin position="681"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="794" mass="87661" checksum="FBBCB45A2D4438DB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIT1</accession>
    <name>A0A1Y2BIT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_518065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIT1"/>
    <dbReference type="InParanoid" id="A0A1Y2BIT1"/>
    <dbReference type="OrthoDB" id="2536450at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012508367" description="DUF7729 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="2">
        <location>
            <begin position="57"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="271" mass="26574" checksum="51295CCEFC247061" modified="2017-08-30" version="1">MVNIKAIVAGSLVVLSGTTALSTTCTAQVASLALGDAGSCLALTSLLPVLSASGSIIDSVNSYLSNLCATSTPTCTNSTLTSAESSVQSGCSSDISGGGTNAAEVDALLSLLQFYPQVHTAGCAKNQTTNEYCLTSTLEQVQNGTGQNITSSFLTSLLAGTGSTDSITQFASTGQLCTGCVQTIYDQALSANSTIASSTIGQAITSQCPAFNSTSATGVSSVSTSAAAATSSAAQSTGAAGKVEPLKNVLPFAACAGVMMAAVAVGGSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJE7</accession>
    <name>A0A1Y2BJE7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_515473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJE7"/>
    <dbReference type="InParanoid" id="A0A1Y2BJE7"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62551" checksum="5D2A0D8AF977D2B7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJE9</accession>
    <name>A0A1Y2BJE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_514130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJE9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJE9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJE9"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="339" mass="37056" checksum="B194D5FB11A29A93" modified="2017-08-30" version="1">MSTGDHSLQPPADGISAVVFSPDSTRLLVSSWDGSIQLHHLVAPPQPPAIFPHPAAVLAICFGSSPTIAFSGGLDKRVRQWDFETGQTRVLGKHDDAISCMVWSAEYNVLITGSWDSTIKVWDPSAEIPLRSTQTLPSRVYNLSLAASTSTLLVSMAHRHVYVYKLPELAAVQEGQPLRPSQERESALKFMTRSVACMIDGKGWASGSIEGRIAVEYFDPDPATQSQKYAFRAHRQQVDGVDCVYPINALAYHPVHNTFASGGSDGFISIWDHSAKKRMKLYPKYPTSISSLAFSPDGSKLAIGASYEHDNAVNEHDRGTIMLLVKDTVMEDCKPKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJG6</accession>
    <name>A0A1Y2BJG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_137396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJG6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJG6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="356" mass="38416" checksum="3115797BDD27905D" modified="2017-08-30" version="1">MTTTTKATRNDTTRRPLFHSYTDDDSVIAATTTATSTNMRLMDMEMSNEIHRVGIGGGELASSAKYPQTSSNIGGGGVGAAMSTPRLQALRSEHAATYSPSHATYPTDPLDERMTTSSLMPSRRGFPRTPSPPPSTSSSYLPRTPYTSLLNPSPVHLNQPRQHSPPSSVSETSTPLRSSAYTSSPRSPYTYTSSSESPNTSYSRSPAASISRSPNTPSSSQSPTASSSSRSPNTSPRSPRSYFRLPLAYSPPSKRGKLSPAPDDIASDEKGSVSVIVLNDDDHEMALVHESRLAWQMSMIALGVLGMLAVLCAAGFVLFSRKLTCVSMSSISISTHRRRAVLWRYCKRDDVLIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJI8</accession>
    <name>A0A1Y2BJI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_515713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJI8"/>
    <dbReference type="FunCoup" id="A0A1Y2BJI8">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJI8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJI8"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="310" mass="34151" checksum="808C14BA7199783F" modified="2017-08-30" version="1">MRFADIAVNLTDPQFTGNYHNRQKHPSDIDSILSRAKARGVERILITGTSLEESRTSLDLAKKYDLHCTAGCHPTSTNEISKHPSGAEGYLSELSKLVQADRGEGGSRRILAIGEIGLDYDRLHFSSRETQLEHLPALLGLSKTHNLPMFLHSRAPEAHIDLVRLLKQVGWGQDWPGGVVHSFTGSMEEMKALVEMGLYIGINGCSLKKVENIQVVKAVPLNKLLLETDAPWCSITTSHASYPFIPKDTVLEKVSKPDKFVEGKGVKGRCEPVEVITIAHVIAAIKGISIEQVAQAAWDNSTRLFWPEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJT8</accession>
    <name>A0A1Y2BJT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_585968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJT8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJT8"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="338" mass="37559" checksum="38A0E92CA8DE6C96" modified="2017-08-30" version="1">MNIRRKMSYCQTCYTELRPSESVYTTPCCSSPICSRCITRNPRLKEYSPCLRCGDVRTDIGNRAIRDGRLRLEEARRSEHIGQFTIGDDDDEVEIGDEDAPPGYTSDPEPPTKSDKATDTRARHGGAENEEELQAVEVRHPVSRSDTILSIARRYAADPHEILSLNNLPPSTLSTQPHLLRTRQTLLISRRLMPKSKLPSSTLFSTPADKDYSPYEKKPEHSDGNEDEARRAEERRVKRFQLITKTADPCVGRAYVGLAAAEESASTSDGIGFGGSGEGMGGKKTHLPQEGNRAERAVERFLDDDEWEREWGGPARASKGVDGRWKVVGSGLKLGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKU4</accession>
    <name>A0A1Y2BKU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_509258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKU4"/>
    <dbReference type="FunCoup" id="A0A1Y2BKU4">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKU4"/>
    <dbReference type="InParanoid" id="A0A1Y2BKU4"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="6">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="7">
        <location>
            <begin position="210"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="541" mass="58704" checksum="C7DAF2F38B37DA45" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKW0</accession>
    <name>A0A1Y2BKW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyanamide hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_509372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKW0"/>
    <dbReference type="InParanoid" id="A0A1Y2BKW0"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017771">
        <property type="entry name" value="Cyanamide_hydratase_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03401">
        <property type="entry name" value="cyanamide_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="62"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="249" mass="27661" checksum="3CBABFC293B889E8" modified="2017-08-30" version="1">MALDSTHHLWHPVPRSHDHFFTSAPPSQSDLVPYDTKSIPYPTTPLVKATEAFAKSNLPPATLNHSYRIFFYGLAILRAGRPDLLEKLDEETWAVTCLLHDIGLAEKFHLTTNMSFEFKGGIVARDFLLSNGATESQADSVCESIILHQDVFITTGNIHLGGQLIQLATLFDNAGGKAEWVHVKTIEAVCTAYPRGGWSEKFACAVESEMRAKPWSHTTTFEEPGWRQGEKGSKFGSLARGNKLMEPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLH5</accession>
    <name>A0A1Y2BLH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_511197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLH5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLH5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLH5"/>
    <dbReference type="OrthoDB" id="2838915at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="276" mass="30794" checksum="19E69371C4658C83" modified="2017-08-30" version="1">MSEITLVPMTKGDIPTIMALSSAAFSTDKHSLFKAYEKGGTVADELQPEEDIERYFDIGRVRMIKACIKEDGDGDDNTGNKEEGRTTGDGEDGKESGKMIGFTNWGMWPVRFDDPELSEVLKVKEIEMADQHIPFTAPVPPPSLPLSTTPRIEYLGAITHEHLMALQIRLNAASLPNPVLYCLGITVSPEYQSRGVAGKLLADLCQFADHHHASCWIHLSDHLGGKKALERNGFQQVAQLEIDLDKWATKKRQDGQNWGSYTHRYFRREAKGVNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLP7</accession>
    <name>A0A1Y2BLP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_511452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLP7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLP7"/>
    <dbReference type="InParanoid" id="A0A1Y2BLP7"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="172" mass="18354" checksum="2D1625D8CF4CC017" modified="2017-08-30" version="1">MSGSLPITFHPAHAQPFTLEQAMLLEINILVAEIQRLENSIQHLRETQSQLTLFLQTEDDQDLRQAYQENEIVIDSQSERITLIKVALLNKVGQDSAAHYGISDIDTSTTTRTGTRTGTGIGTGTGTAAGTGIGTATGTGTDGVRNGTVNQSGTENVVHEEDGEEAQPGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLQ9</accession>
    <name>A0A1Y2BLQ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_563148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLQ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLQ9"/>
    <dbReference type="InParanoid" id="A0A1Y2BLQ9"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="150" mass="17461" checksum="D8785901CC32283F" modified="2017-08-30" version="1">MVSLARTIRNFRRAGFKEWWRQLQYIGDAKYGRQVGSDQFGNRYFENMNPTEEVPGRQRWVDYTQHEYNATQVPPEWHSWLTHIRKDPPTEDPIMQASTPPWKIPYVENLTGTRGRFITYPTVVPKINAWEGKVAPRGAVAKQPDTTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLS6</accession>
    <name>A0A1Y2BLS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_460712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLS6"/>
    <dbReference type="FunCoup" id="A0A1Y2BLS6">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLS6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLS6"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="336"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="637" mass="70302" checksum="271ED144A76E2BD2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM69</accession>
    <name>A0A1Y2BM69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_503031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM69"/>
    <dbReference type="InParanoid" id="A0A1Y2BM69"/>
    <dbReference type="OrthoDB" id="3257643at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="301" mass="32835" checksum="3DD8947F3AEBD5C6" modified="2017-08-30" version="1">MAVHSSTLKKTPSSPEISFSVSGYRMNTSSSMNTLMHGSSGAGSGLEDGDNRTRNAKAQRRHREKRKAHLKALEESVQLLTAQLEDARRQLGQAAFASASRIGNAPMSPQSKDIVSLQAENAYLREENTDLRRQLYTYRVSYGQVAPPHPGQMDGGEVKSEPGGFGVTYGQSSMASPRAGERLRQSGEYAPAASPYIPSAGNFPDPRSTSMSGQSPSTPLESRYTPVRYESHMYPPSAPAQPPPHQLPRQGLYDLSHQYRGGGGGGGDENPAEQQHNMWGPEDMEMVDKMQKNGVENIKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM70</accession>
    <name>A0A1Y2BM70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_32291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM70"/>
    <dbReference type="InParanoid" id="A0A1Y2BM70"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="319" mass="35116" checksum="360CA482CF1C9083" modified="2017-08-30" version="1">MPPRRSKRHTKIGETVSSKAGNKRKHEESVQEHEEGKPETTTNEHPQKTSKGGRSILDYLLSDEAFNLAYPAIEQGKGETDLPSGQGDKTPPSESAGKRDTSESESAIHYPRDHLTPFQNLVAALILSKPLSHNLGHRTIHTLLNPPFSLRTLSDLDEAGYEGRRKVMWDARTQHKEKTAGQLGDLVEGVRELCGDPGREEDLSDLKGIKEQLEGIKDAKDAQAKLQSLLTEIKGIGPGVVSVFLRRIQGDWEDVFPYIDNRGTKAAVALGLLKEGDGAEDLGHVVNGDRVKMVKLLDVLVGLQLEKKIDEAKKAIEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMF8</accession>
    <name>A0A1Y2BMF8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_513190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMF8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMF8"/>
    <dbReference type="InParanoid" id="A0A1Y2BMF8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="549" mass="60747" checksum="0402022B44CD7819" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMG1</accession>
    <name>A0A1Y2BMG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_32784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMG1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMG1"/>
    <dbReference type="InParanoid" id="A0A1Y2BMG1"/>
    <dbReference type="OrthoDB" id="2564627at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="32987" checksum="591A37DEA31CB86A" modified="2017-08-30" version="1">MSFNYTNPYAPPSQAPPAAFSGLPGSVNSYQVLLSGIPLDVRDADFQDLMTRIGIVDFEVTPLYDTSGKFLGKAIMTVRTGDEAELIRREYSGQTFDADVKLTVHHILSPTQPLPAPSVTPMQRLVPASAKAAATRPAAPPTGPASKRPNARAGPSTNAATSLKPGKKDDGKPDGLKLLARLQPQVKDKQKQAALLAKQKANLKAKTPGAALLSRMTHSSPVTSKVTAKINASAKAPLNASNKLARAKAKANQGQGQGQGQGTQVVKPVIPAKPTNGGAAPAGGKAKDKPRHKTQAELDDEIAAFQRSRRFAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ACV8</accession>
    <name>A0A1Y2ACV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin binding cofactor C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_451076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000137">
        <property type="protein sequence ID" value="ORY20383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ACV8"/>
    <dbReference type="FunCoup" id="A0A1Y2ACV8">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ACV8"/>
    <dbReference type="InParanoid" id="A0A1Y2ACV8"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="5">
        <location>
            <begin position="165"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY20383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="294" mass="32305" checksum="B4E79EE05B141B68" modified="2017-08-30" version="1" fragment="single">RNMASTSTAADFHKTYTSSRAEIETLLTSSTRPPLTDISKALGSLRGELRAILAGLPAYDQRKYELDLIELERRLGSLRAKEKPRSKFTFSKPASTSTSTSTVTSRNPELGNTAKPSQSNSNSNSISEPLNETSDFGSSSTSSHSLHHETHQYLTLDRSEPEPEPVALTLESIEECVIDLRSTRLTALHADGLKKCVVLVGWVQGSVLLSHLEGCLIVLGARQVRIHSSTASDILLHVVSLPIIEHSSNLHFGPYPRSLFSDLDKGIQLTQSKFDQVQDFDWLRGGPSPNWTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE66</accession>
    <name>A0A1Y2AE66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_562833</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000123">
        <property type="protein sequence ID" value="ORY20868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE66"/>
    <dbReference type="FunCoup" id="A0A1Y2AE66">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AE66"/>
    <dbReference type="InParanoid" id="A0A1Y2AE66"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY20868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="108" mass="11826" checksum="6B3169840389E6A0" modified="2017-08-30" version="1">MSYEKGDANKGASIFKTRCAQCHTLGAGEPNKVGPNLHGLIGRKSGQVEGFSYTAANVNKGVHWDENTLFEYLENPKKYIPGTKMAFAGLKKAKDRNDLITHLTEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEB5</accession>
    <name>A0A1Y2AEB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C-type lectin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_554493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000122">
        <property type="protein sequence ID" value="ORY20909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEB5"/>
    <dbReference type="FunCoup" id="A0A1Y2AEB5">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AEB5"/>
    <dbReference type="InParanoid" id="A0A1Y2AEB5"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="195"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="386"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="9">
        <location>
            <begin position="604"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="7">
        <location>
            <begin position="771"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY20909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1025" mass="114877" checksum="3A90C28A6D437AE4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFJ8</accession>
    <name>A0A1Y2AFJ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_474521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000112">
        <property type="protein sequence ID" value="ORY21373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFJ8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFJ8"/>
    <dbReference type="InParanoid" id="A0A1Y2AFJ8"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="297" mass="32787" checksum="95E0540BAB57F1A5" modified="2017-08-30" version="1">MRTRVSRRAMLYVPGSNPRMLEKSLVSPADSVSYDLEDSVAPSKKSEARKLIGELLDGERRPKGEVMVRINAVGTGNESADLDDALRTRHIQAIALPKTTDPEHIEWVVSRIQRLCPKDKQTGGSNAIRIIAMIENAIGMIRIEQIAQSGQGHLDALLFAAEDYCADVGLIRTENRLEMLYARSKLVTTAKAFGLQAIDLVCVNYKDPEALRIESEEGRRLGFDGKQAIHPDQIEIIHRAFAPSPADIEKALKIRDAFEKHDLAGRGAFELDEAMIDAPMQKQALRILAKAKAAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH89</accession>
    <name>A0A1Y2AH89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_508333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000107">
        <property type="protein sequence ID" value="ORY21650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH89"/>
    <dbReference type="InParanoid" id="A0A1Y2AH89"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013322330" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13160" checksum="E29C6FF7018F3DE9" modified="2017-08-30" version="1">MTFTNVVVAVVAVVAVVKANDEVVDIEAGDGDRFEAVCLQCDRDEVGSGKIGVRVEGRTTSMSTRSPRDRGDSHLGYAVDKYQGFQLNCVLALAHEWHRIHSRRQVQQGMNNWGPKTACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJF3</accession>
    <name>A0A1Y2AJF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_551182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000090">
        <property type="protein sequence ID" value="ORY22622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJF3"/>
    <dbReference type="FunCoup" id="A0A1Y2AJF3">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJF3"/>
    <dbReference type="InParanoid" id="A0A1Y2AJF3"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000101">
        <property type="entry name" value="Wos2 protein (P21), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="134" mass="15547" checksum="35799698DCD555AB" modified="2017-08-30" version="1">MAPIHPEIQYAERSSATDPEKNIIYFTINAPDIKGEPKLEIKPTEIIFAATAGDPSKGVPEKEYKFDLQLYEEIIPEETRKITTSRAIILVLRKKELKAEYWLRLTKEKPNRNWIKTDFSKWVDEDEQDGVAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJV2</accession>
    <name>A0A1Y2AJV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_550882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJV2"/>
    <dbReference type="FunCoup" id="A0A1Y2AJV2">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJV2"/>
    <dbReference type="InParanoid" id="A0A1Y2AJV2"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY22762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="555" mass="61223" checksum="757C8BEB70361CD9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK71</accession>
    <name>A0A1Y2AK71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Retrograde regulation protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_550572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000086">
        <property type="protein sequence ID" value="ORY22904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK71"/>
    <dbReference type="InParanoid" id="A0A1Y2AK71"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="490" mass="53279" checksum="9E5E89DD41110447" modified="2017-08-30" version="1">MITDRDEEEKGAEHNVSAVVDDTLPQWDEARKRKLYRKVDLHVLPSLIILYLISFIDRGTLANASILGIKTDLHLDTTKYNLVATVFLFTYSAFEIPANAVLQKVKPNIWIATICLAWGIVATMSGLVKNYAGALVARIFLGVAEAGFFPGAVFLVSLWYPREQLQFRISVFFSMGSLAGAFSGLIAYGVAHMEGKGGLRSWRWLFILEGIFTCALAPCILWILPNSPESSKWLDEEEKAYLRSVSVLAGGGGTHVPFQKEHLYAALKDVKIWLCGIMGMGTTLPLYGFSYSLPTVLVQLGYKAEIAQLMTVPLYAVAAVWTITVAIVSDKIGRRAPGVLVSFSLALIGLAAEWGLPKTGVAKTRYGCLFFIPAGLYAALPGSLSWGSNNAAPRGKRAMATALQLTVGNISAAIGTNVFLGKEAPNYPTGYGISIAVLVLGIICAGVLWLMCNRENKRRDGMDINAIQATYSDAQLEAMGDKSPLFRYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK95</accession>
    <name>A0A1Y2AK95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_458041</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
        <property type="protein sequence ID" value="ORY22979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK95"/>
    <dbReference type="STRING" id="71784.A0A1Y2AK95"/>
    <dbReference type="InParanoid" id="A0A1Y2AK95"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000286">
        <property type="entry name" value="Zinc finger protein 770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN RSV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY22979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="269" mass="28559" checksum="FD6C248856350502" modified="2017-08-30" version="1" fragment="single">KGKNGATGPAEGKAKPHLCQICQRGFTTGGHLQRHQRIHTGVKAFKCPFPGCETRTSRQDNLQQHYRTHLSPTLRRGSGSAARQAVAAAMEAAGLKSSSTRAPRKSKGSANGTPSSTASAGHIPSPYQTPTSQAGPYAGYSMYDPQQYGGYPAHPLPPPGIMQTQSAASSRVPSPANGHSSGHSSVTSIPGHHQPPYFPQPYSPAYSFGGGMHQQPYRYGPGPYGPPSHHNLYSPGIAPEHQGHLYSPMQAGFPTHSRESSYNVINPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALT6</accession>
    <name>A0A1Y2ALT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase 2C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_549086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALT6"/>
    <dbReference type="FunCoup" id="A0A1Y2ALT6">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALT6"/>
    <dbReference type="InParanoid" id="A0A1Y2ALT6"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="526" mass="57059" checksum="4D8126DC9FECD18E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALV5</accession>
    <name>A0A1Y2ALV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_487103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALV5"/>
    <dbReference type="FunCoup" id="A0A1Y2ALV5">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALV5"/>
    <dbReference type="InParanoid" id="A0A1Y2ALV5"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="214" mass="24697" checksum="1A7F6743F7D46F19" modified="2017-08-30" version="1">MKSINRFLYGPTPEEKVRDWQAKLRTQQRQLDREIANLERHTQKSRSELKTLAKKNDVKSARILAREVVRANKQRDRLISSKARVGSVQMQLQHQLSMVKVTGAFQKSTEIMKTTNQLVKLPQLSATMREMSMEMMKSGIMEEMMEETLDSVDDDELEEEADAEVDKVLFELTDGKLGQAGKVGGELPANKEEEEEDVEEMQRMQREMQDLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMU4</accession>
    <name>A0A1Y2AMU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_346299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMU4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMU4"/>
    <dbReference type="InParanoid" id="A0A1Y2AMU4"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="280" mass="32404" checksum="1C3E070CA0E48EB8" modified="2017-08-30" version="1">MVSSPRKRTGKARVSTLWDADYLTCPQAGISWPIQELTSDPVAKFFQPGSKLDWHYNWNKNWDVLLPQTAPGLKIDAEFVPMIFAPEYLNNEYKLQNGYRMILGYNEPDYDAPTSVRRTPQEAAKAWVELAKLRTSIEIKLVSPGVAASLDWLKDFMAFLPDHSKPDYIAVHVYTTTFDSFKETVERYWRTFQLPIVVTEFAMTSFDPNVPPPQSQQQVHDFMGQTTKWLDETEYIIRYAWFGAVRDLSHLHGVHPYNRLMDQHGEITPLGWQYIQGGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN16</accession>
    <name>A0A1Y2AN16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_582790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN16"/>
    <dbReference type="InParanoid" id="A0A1Y2AN16"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="760" mass="84586" checksum="0B76D4DB3FEBACB2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN46</accession>
    <name>A0A1Y2AN46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ETC complex I subunit conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_561991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN46"/>
    <dbReference type="STRING" id="71784.A0A1Y2AN46"/>
    <dbReference type="InParanoid" id="A0A1Y2AN46"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY23375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="135" mass="15053" checksum="8699073638431ADC" modified="2017-08-30" version="1">MFRATRPLFAAIKPIKASTAITGLAPHPDPIPALKELYRTNLNILSTLPATSVYRQATEALTKHKLSVVEKAGDDVQAIESEFGQIVEVSLEEGKSEQGLIGKMVEWKSWEPLEHEAPPDQWRYFEPGNEEESLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN76</accession>
    <name>A0A1Y2AN76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CTLH/CRA C-terminal to lish motif domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN76"/>
    <dbReference type="FunCoup" id="A0A1Y2AN76">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AN76"/>
    <dbReference type="InParanoid" id="A0A1Y2AN76"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="258" mass="28746" checksum="18E268EC1047BF3A" modified="2017-08-30" version="1">MSSQAIPPVDMKRWEDELSKAEISKSDLNALVYDYLLIEGFSDAAVEFARETGLPADVDHAMIQERMEIREAVEEGRVEEAVRRVNELDPEILDTNPPLLFHLHLLRLIELIRLEQIDDALSFATTELAPRGAQNPEFLTDLERTMALLAFPDLARFADDSPTENHPPPDAATLAYLQDPVFEPICQLMRRSQRVKVAKELNAAILDSQGQGMETKLSGLVRLMAWGESRLEKMGGLPAAERGKGTKWADAVLSDVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANC8</accession>
    <name>A0A1Y2ANC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_342435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANC8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANC8"/>
    <dbReference type="InParanoid" id="A0A1Y2ANC8"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="6">
        <location>
            <begin position="356"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="774" mass="84596" checksum="18ED3F8261BBC4E1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP63</accession>
    <name>A0A1Y2AP63_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_547453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP63"/>
    <dbReference type="InParanoid" id="A0A1Y2AP63"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11659" checksum="6C91AD0D614047AD" modified="2017-08-30" version="1">MPSPNLFQSLGYVYFSYTTPLSIVAKFYAHGGIVLTSQDPYRLPVDIYFAPPGDRLASYLTARQLVVHDPCWVDACIVEGRLVDLKAWVVECPHSVTIKTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP83</accession>
    <name>A0A1Y2AP83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Biotin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_546890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP83"/>
    <dbReference type="FunCoup" id="A0A1Y2AP83">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AP83"/>
    <dbReference type="InParanoid" id="A0A1Y2AP83"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="457"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="778" mass="84616" checksum="8AA9AD8CB8E0DF57" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2API9</accession>
    <name>A0A1Y2API9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_500107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2API9"/>
    <dbReference type="InParanoid" id="A0A1Y2API9"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="502" mass="55064" checksum="B8CC38D0A60CE54C" modified="2017-08-30" version="1">MSDEKEAPSFTVEEVHNQVVTLSEDLSERQLVRKLDIYVLPPLTILYLMSYLDRTNIGNAVIFGLKADLGLVGSQYNTALAIFYACYVVVEPPSNTVLKRSRASVYLTFLMLCTAVVGMCMGFVKNFSQLTAVRALIGITEGGFWPGIMFTVGQWYPRREAAYRASIMFSAAGASGAFGGLLARLLEKMDGVAGREGWRWIFIIEGIATFVVAVAMYFFIQDSPETATFLTEVEKEIVIARLTTDGQCMPTAFKWKYIRDTFTSPLVFLMAITQFGTYIGVVSFTTFAPAIVNAMGFDAGLAQLLTVPPYVLGCISTVLVGYLSDRSQTRYPYVIGSTTIALLGYLVLRFTANVPAQVSQPSRSASSQLTFQYVACCLVCIGCLPLVPLEIAWNGNNQGGTLKRAVAIALQVGASNSGGIVGSYAFIATESPRYYTGHAVCAGFMGITILFASLSALYIVYQNRKRDRLYGPAADILPTMTPAEIDEEKERGDHARWWRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ09</accession>
    <name>A0A1Y2AQ09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_320097</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ09"/>
    <dbReference type="FunCoup" id="A0A1Y2AQ09">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQ09"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ09"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="276"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY24576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="507" mass="56603" checksum="57E4C1051C0A5C21" modified="2017-08-30" version="1">MEEIGEEVVEAGGGREEIEVQNKRARRVTRRDKRVELLGDLGRRGLREKMSFGYPRRSVQSYLGIAGQGIMGCKFPPLLTLFSQPDGAKTIEGEFFAALVKAGAVSSDNADDHRKVDVQRAARTDAGVHAAGNVISMKMILEPPIPEGFKDLADYVNSFLPPTIRMWGFVRTVKSFQARLTCDSRKYEYVFPSYCLLPPSRTDPLALQLDASSPGWRDTLGAAAEFADAAEPTVKSGEGGEGEGDVDVDPKARGEYERRRGWRIDPGTMGRFRDLVKEYLGTHNFHNYTVGKPFNDRTVKRYMIEINVRDPQVVGEIEWVSVSIHGQSFMLHQIRKMMSLAMLACRTGSPPALIPETYGPKRIHVPKAPPLGLLLEAPQFSVYNMRVSEKTNGLEADREPVDFGLYQAQIDEFKLKHIYDQLRADELQSHVFHKWIRQMDCAIGPTLSFLNTHGIIPPEAQLSINKSKGDNKDAAADGAVDNALQNEIQSEDEEVDQELLKRGELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQC1</accession>
    <name>A0A1Y2AQC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_545886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQC1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQC1"/>
    <dbReference type="InParanoid" id="A0A1Y2AQC1"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30895" checksum="F3BC7CCC4398E326" modified="2017-08-30" version="1">MGSSLEVPPDLIGQSSLYNSPDPLLRRLRLDDSTGSSISDVERYFKGKEVLVLYAGSEAGSNNLKHFHRDLTTMVMRYLKTLGVIYISTDTSPSAPQRVLASHPWLRLIFADNSDFASPGDGKGKEVEMEEVARGEEFIQAGEIELGMEKVEFGLEENENDYVRPLSRAAVTALMSAYATPSVSIYHLGTHTFIAKNVRLSAFESHNIDKNYATWRNGGTPSLRLIDILTAMKWPLILLVLAVLYHSLVYFGGQEYHVLPRLLDSLSWQSKSAGVVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQD1</accession>
    <name>A0A1Y2AQD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromatin structure-remodeling complex subunit SFH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_546165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQD1"/>
    <dbReference type="FunCoup" id="A0A1Y2AQD1">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQD1"/>
    <dbReference type="InParanoid" id="A0A1Y2AQD1"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54492" checksum="C8D66725E601760A" modified="2017-08-30" version="1">MYRAYLTGQAPPPAYTRPAQPVKHVYTTPAHPAGPLAYFSPPPSQPTTDPSMSYPPTSQGLYTTYPSRLRTGVTGLIQPETITGGPKEREWLLAELDRELGLARGGSTPPPRRVATMSGRARRVNYAEAEEEESDGEEEDEDDARRGWTGTGSTEQQAAMRAGKLRKKREEMDRGLTWLGDRTPGERVLTRRARMTAHTYRSEEDLEREKDRPEWLVPITIDFDVPSTHPDSMGIKLKDRFLWNLNEPHMTPISFARIFCDDVGIPANQHAQTIADLIQGQLEEAAGCVELDLVDREVGDGDVVWDEVERDDDDEREREVGQVDADCRIIVNLDVQIYTHILRDRIEWDLSSPLPPSLFAKHYCTELGLTGEAIPLVAHAITDELLKHRRDALELELFARSHPTEQAKWDKGSSGIPRVNDRRGAKRLVGVWRDWWERDEFGPILVELSMEEMERREMERTREARRMIRGLTSGKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQF3</accession>
    <name>A0A1Y2AQF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_320751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQF3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQF3"/>
    <dbReference type="InParanoid" id="A0A1Y2AQF3"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF6">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="298" mass="33598" checksum="CCBB79C0C350ECAB" modified="2017-08-30" version="1">MGKRIVFTGGSGKAGRHAIPYLLAQGHTVLNLDLIPLDNPDVFTLKTDLADSGQVFNALSSLFSMSEYSLPERHGRPDAVIHFAAYARNMLVPDNELFASNVKQTYNVVEAACKLGIPKVIIASSETVYGVCFTQGDSDFHSFPLDEDTYDCDPEDSYACSKLCGERIARTFARRYKTDIYALRIGNVIEPHEYALNFPTYLADPPSRKRCAWSYIDARDLGQICHRAVLRDGLGFQVFNATNDTITLNEKTKDFLGKESPHVKITRELEDYEAPLTNKKIRDVLGFKEEHNWRQYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQR5</accession>
    <name>A0A1Y2AQR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_547305</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQR5"/>
    <dbReference type="FunCoup" id="A0A1Y2AQR5">
        <property type="interactions" value="675"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQR5"/>
    <dbReference type="InParanoid" id="A0A1Y2AQR5"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000007">
        <property type="entry name" value="SNARE complex subunit SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="143"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY24295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="224" mass="25875" checksum="DD6F238495C111A6" modified="2017-08-30" version="1">MVRSTTIFRVSDALPLAASVDDETTEKALTEYKQQSKLVFRRLNANSEPACSIESGQYTLHYLIVDKVIYMCICDATYPRKLAFSYLDELSKEFQRSYEGKIETVTRPYAFMGFDTFISKTTRLYRDSRTLTQGGGPSAPASQMDQLNQNLKDVTQIMTKNMEDLLWRGDSLDRMSHLSTSLRSESAKYRKAARNINLQALLRKWAPIGGIAFFFILFMWWRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR24</accession>
    <name>A0A1Y2AR24_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ketopantoate reductase PanE/ApbA C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_590450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR24"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR24"/>
    <dbReference type="InParanoid" id="A0A1Y2AR24"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="269"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="706"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="722"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="847" mass="92637" checksum="04F33A4C604DFA8B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR84</accession>
    <name>A0A1Y2AR84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_471784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR84"/>
    <dbReference type="FunCoup" id="A0A1Y2AR84">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AR84"/>
    <dbReference type="InParanoid" id="A0A1Y2AR84"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000002">
        <property type="entry name" value="Invertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="411"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="525" mass="57628" checksum="CDE46A0DC07CA3E5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARS0</accession>
    <name>A0A1Y2ARS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_306025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARS0"/>
    <dbReference type="InParanoid" id="A0A1Y2ARS0"/>
    <dbReference type="OrthoDB" id="2596167at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="409" mass="45647" checksum="2123EFC7FE011F2A" modified="2017-08-30" version="1">MVYSAQEIQEARALLIKADFTNIDTMVVAAPIGCIIEALIAGSCLQMVLRYFRGPKRDNPLGRIGIVVIMVLVCIQIFLCNSQMYRLVHYYSDYARTFLLDWFLFNVEGMIYSIVVCSVLFLYAWRAYLVWDRNKIVLYGTMPLLGAQLLVGLGCGIYGMAVPWPLRLMSDDEFNSWIPEYLHRKDMYFPLRMTTVAAQLITTTVLSFLICTGVLRHRGVAQETDNAISRIVFISGESLLPMVVLSVFFVVGAALEPTQGMLLTRVCGHLSPSIYFHGLMTSLVSRERVAQLLNASSIRHLHDRKSTNLQSGVIITSETHLFTESASSFPHQRLVTPPTSKSVKTSNGDGDGDGDGDGNESRYSVDFHDGLKSKDKNAKGGWDVYAMSEISPKDLEVEIEDDTGKSHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS04</accession>
    <name>A0A1Y2AS04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_561148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS04"/>
    <dbReference type="InParanoid" id="A0A1Y2AS04"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="191" mass="21044" checksum="77725A9CA38C06BA" modified="2017-08-30" version="1">MLAIEQPAEAKQKHEIRLVDDRFETADIVRRFLDAATGKSLPTPQTISLHQLGDSIRFAKKYDCPLICALLLSIFKESLGAVDASGKTHSSSTFFSIAAQLDEPEICSAALKLGIGNFHEHHRQGDNKDRSSIPGRPGFDIIAFPLASFRDLPIDYLWALGRVSLVSGDKAKAEEFKRLIEVAKRTPVAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASV6</accession>
    <name>A0A1Y2ASV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_543419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASV6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASV6"/>
    <dbReference type="InParanoid" id="A0A1Y2ASV6"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="166"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="762" mass="84690" checksum="2649CD9DD035BA1A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATQ7</accession>
    <name>A0A1Y2ATQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Las1-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_542626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATQ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2ATQ7"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="473" mass="52826" checksum="82F8884ED8946BF8" modified="2017-08-30" version="1">MRAPRRLPWASKTELSELYELLFAPSADTASRQRGVARMSVYISSPSCPAFIHLLHTLVAASLRPSPPQSAEESQSTRLAMAMAVVRFVNGMVDPLQTGPYARPISHIAASLGIPPSLVSLRHRATHEDLPPLPLLEQSTYQAIEYIHRYSFLPMLSSSSLEGPAIRDRRTKIQGLIGRWKRVMKERLREREVREDSESGKEMRRVRRALEAEDAEDVVEALCAEGALVPLARKKRPNINAVQPTDTSLLVWVPLLAHLGTSNPSIASFLADQILTTLLSSDSPQDQDGTSKSAVDLTEDVNEKRNERISFRWTLATWFLWIWTSGEAEQQNLCLDKDEKDDLWRRLMTGLIHSDEIVVKLYRSLLRIDPGRRGLTGLEACLLEDGADEELAGLEDGHSDGHRDKGDILLEMENRLSQLENKVNKGFVSGDSGNITLVDGDVDGEMVGQAEKGWRLVPENEWKPCPIGMWTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATZ5</accession>
    <name>A0A1Y2ATZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_589914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATZ5"/>
    <dbReference type="FunCoup" id="A0A1Y2ATZ5">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATZ5"/>
    <dbReference type="InParanoid" id="A0A1Y2ATZ5"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="125"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="370" mass="40335" checksum="0EC4B9C69F4D050D" modified="2017-08-30" version="1">MSSRRDIGRIVFDVAAFAASQLAVYYALRYVLSSLDQSSPTSKKAKQKGQSLLTQTGLSDSQLAALELDEYESTIAGEIIPPSSIDVTFESIGGLDEIIASLRETVIYPLTFPELFAGSNGLLSAPKGVLLYGHPGCGKTMLAKALAKESGATFINLPLSSLTNKWFGESNKLVAGLFSLARKVQPSIIFIDEIDSLFRERSAGDHEVTGMMKAEFMTLWDGLTSGTDTRILVLGATNRPNDIDPAILRRMPKRFPIRLPNMQQRQKILALMLGHTKLAPDFSLSQLAARTDGLSGSDLRETCRNAAMAPVRELMREKGKSGKEGLEAAQKEGFKLRPLRMDDFVLNDSHAYAHVEPSRKPPGGYGDPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUU3</accession>
    <name>A0A1Y2AUU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="16">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_273987</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUU3"/>
    <dbReference type="FunCoup" id="A0A1Y2AUU3">
        <property type="interactions" value="808"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUU3"/>
    <dbReference type="InParanoid" id="A0A1Y2AUU3"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="304"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY26050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="526" mass="58833" checksum="B040595DAE015E28" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV81</accession>
    <name>A0A1Y2AV81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_541068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV81"/>
    <dbReference type="STRING" id="71784.A0A1Y2AV81"/>
    <dbReference type="InParanoid" id="A0A1Y2AV81"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="518"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="686"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="769" mass="84142" checksum="DCE17A2CA348F04C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVC9</accession>
    <name>A0A1Y2AVC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lecithin:cholesterol acyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_542194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVC9"/>
    <dbReference type="FunCoup" id="A0A1Y2AVC9">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVC9"/>
    <dbReference type="InParanoid" id="A0A1Y2AVC9"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="742" mass="83078" checksum="324AF5FB64144214" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVT5</accession>
    <name>A0A1Y2AVT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_251687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVT5"/>
    <dbReference type="FunCoup" id="A0A1Y2AVT5">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVT5"/>
    <dbReference type="InParanoid" id="A0A1Y2AVT5"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF2">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013096030" description="Protein ROT1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="236" mass="25571" checksum="E8ACB9F3AF403FF7" modified="2017-08-30" version="1">MMIAILSLTLSFLALARAAPDFSSANNLTSIAGTWSSNAAVSTGGDFCTPAEMKFDYPNNTGISYSFTDDGFFEEAQYRYTANASNPSCIQATIFWQHGTIGFNDNGSLTLYPFGSDGRIQVQDPCAAVTNVITYYDQQTLYSDWGITVDAQTANYVLRLNRFDGAKMPPMYLIARPPNMLPTQILTGVNASGQTVARKRSTSDVSQFWQRSAAPERISAREGMMLGAGLVGVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW27</accession>
    <name>A0A1Y2AW27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_589496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW27"/>
    <dbReference type="InParanoid" id="A0A1Y2AW27"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="62"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="454" mass="49000" checksum="92C3B54E316455A1" modified="2017-08-30" version="1">MAAPLDELSRALSQTTINGIEVVPPLGRQPPLSEEKIGDDKEFETEMADIPFEYPEGGYGWVVLGCCMTFAALTMGWGVSWGVFQSYYIQAFPNESPSSLALIGGLTGLFMNTTSYVSGRTSDKFGFKRVLYLSTFCSWLSFFLASWSTKLWQIMLTQGVMTGISAGMGLPVFFSLPSQWFHRRRGLASGLAVGGAGFGACICTILVRLMLVRIGVHHTLLIYSFINLILMSVATFLLRGQPNSPEANKSGTGPWFDPRIWKIGSFYLLEGCLLINTFGYTCVFFYLSEYASTLHHPKSSLAAAIPLSIANLCAGIGRVLVGFLADRIGALNSLFLSCLLASVFIFSLWLTATSFGAVMAFAVLYGLVAPTYLSLIPIAAIRVVGSDNLASNVGVCLMLTAPGAFAGGPVGGAILKATGQYKWLIVFAGAMHAFAAISIIICRFVLQRRILCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW47</accession>
    <name>A0A1Y2AW47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_257350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW47"/>
    <dbReference type="InParanoid" id="A0A1Y2AW47"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="160" mass="19106" checksum="8EBDB17D6D1821BC" modified="2017-08-30" version="1">MLPKETRQSNNQCTSHVDSIKLKDILSLTILHTVHIHVHTVLLHLSDTNIRLEVKRDNAYVRLSNHLAESRRGRWVRVRVRVSFTRRRMRVRVFTFSAWRRRTMRPVFSSWWGRGRTMRPVSSSGRRWKWSMRTVVGEWESTTTWRTSVSTSSMVMFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW55</accession>
    <name>A0A1Y2AW55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_540266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW55"/>
    <dbReference type="InParanoid" id="A0A1Y2AW55"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="719" mass="78974" checksum="267DC2067921FC00" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW93</accession>
    <name>A0A1Y2AW93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_594680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW93"/>
    <dbReference type="FunCoup" id="A0A1Y2AW93">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AW93"/>
    <dbReference type="InParanoid" id="A0A1Y2AW93"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="925" mass="101326" checksum="D9137920C027F9DE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX80</accession>
    <name>A0A1Y2AX80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_541036</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX80"/>
    <dbReference type="FunCoup" id="A0A1Y2AX80">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AX80"/>
    <dbReference type="InParanoid" id="A0A1Y2AX80"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="204"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="279"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="505"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY26505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="660" mass="72951" checksum="80B7D65D802B1DFB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX83</accession>
    <name>A0A1Y2AX83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_445399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX83"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX83"/>
    <dbReference type="InParanoid" id="A0A1Y2AX83"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY27181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="687" mass="78083" checksum="E0D721DB6CE88028" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXZ4</accession>
    <name>A0A1Y2AXZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_538513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXZ4"/>
    <dbReference type="FunCoup" id="A0A1Y2AXZ4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXZ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AXZ4"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="468" mass="52798" checksum="2FED91D5684A0A62" modified="2017-08-30" version="1">MASSMVPQEELPVLEAFINIRNRLTALKKDTTKFIRTQDVMPIYNAVVKQVTKLNEIRDEHTSHHASTLASNAASSSADPNSSGPAPPEPNRVDTILADVFALLSLFFMTIGKSRETPAAYSQIAAIRQILSFMNETGAYTEAFLSPFRERIDQLKEMIKRDSEEGKHPEPIVRLMLRKLQGVERQYSDLMASLSVISIELVPIHQRLVALRKQMAILAGEPKPNKTEFKAVMEELRKIDAKRVDGKFLGPGGSSVPEGQALLSGLLDQCFDVAQDIKAREAEEDVSPSLQPIYERLSDMKAQLDRLTLTHRWTLRETDLYNYVMSLREIDSMRVDGKFVDTDGNKAEGQYALLFLLRRCYGLIYRLMSESEPISEELMPIANKLSTIKKCLNEVLKYGGPYTPRDLYPYHLALHQIDSLRRDGKFYADDGSIPEGQAILVAQLSEAHELLEMLKESMSDEESDEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY26</accession>
    <name>A0A1Y2AY26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_226960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY26"/>
    <dbReference type="InParanoid" id="A0A1Y2AY26"/>
    <dbReference type="OrthoDB" id="2564718at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="313" mass="34765" checksum="26F0E0174CF79765" modified="2017-08-30" version="1">MRFTSPSARPALTPFGHRLLYLSESKLANLESPYEASALWKGVILREAVKAAWRSVDEGAVADLNDWHSKGAMGLDVIGEDEDEEYEYDEEDEDTTGYTTGGREERWFEDLVSSFGEDEDERPIEHEWVESNVSIPEFDDYEYEVGEAYTFPVTQSPPSTPLVTPAADPASSADWVVRIVAAEDDDLDDQVEAVDQVDPSELGLDVDAIERPHRLRQLGGRLEPVTPSQLPLPSPLTLASFSLFPITPVTSPLESPDGYPSDVMEYDDLDDCADDFLLPPPLARSFSSVTSRLSWTVMVNASVSHHLLTRVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYB2</accession>
    <name>A0A1Y2AYB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_497549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYB2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYB2"/>
    <dbReference type="InParanoid" id="A0A1Y2AYB2"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF3">
        <property type="entry name" value="F-BOX PROTEIN POF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="478"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="626" mass="68811" checksum="B140FEEC73CF103C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYE9</accession>
    <name>A0A1Y2AYE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_537467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYE9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYE9"/>
    <dbReference type="InParanoid" id="A0A1Y2AYE9"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="124"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="671" mass="75651" checksum="C1964FDD87313BD7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYV2</accession>
    <name>A0A1Y2AYV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_536941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYV2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYV2"/>
    <dbReference type="InParanoid" id="A0A1Y2AYV2"/>
    <dbReference type="OrthoDB" id="2138242at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="483" mass="53932" checksum="440BF467820AE2B0" modified="2017-08-30" version="1">MSSTRIGTTVLAPPQPSPNRTVHPTSSLRDPLPDATPPGRSRSGTPESPSDDYMRHPSRSGGRKKGRRERSGEESDEHASPRGDKRRRVKAANGTTSPHDPPRSARLGPSTLAPIKPIGFAASREARREEGDRSVPSPVVMGFDFKAIDGDQLKTVRDTISIKEQQQALIAQRRREVAASQPSTPKELTFKGWTPKESKDIGVGRRREKTRDKVERLSIVTSASEKDIVPGSKSAPLGHAPQLPSPRDPPSGSQTSVPHILPPISGYPNGMTDPRTAPIRRNGDEHEFARQQFYPRAAYPHPVPHTAHPRTIDRRNFTAPHHAGPPPNPNPNPNPNASASPPPQRDTFLQPFNQLYDLLHQTEQLRFDLQSLMHQCEQTYGTQRARMDEFKGTAAQARDLLGSLQASADSLKDMVRYEVGRGREGERREMDELKERIRVLEEGGRGREREVEHDKEKEVEVEKEKEKEKEKTSEIQDTMQVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYW1</accession>
    <name>A0A1Y2AYW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_537890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYW1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYW1"/>
    <dbReference type="InParanoid" id="A0A1Y2AYW1"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="699"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY27676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="754" mass="82204" checksum="5A42A7B099C6CA9C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B035</accession>
    <name>A0A1Y2B035_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_538148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B035"/>
    <dbReference type="STRING" id="71784.A0A1Y2B035"/>
    <dbReference type="InParanoid" id="A0A1Y2B035"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="431" mass="47294" checksum="233F852B76AAE732" modified="2017-08-30" version="1">MTSLPTHSRVILFHLSTTLNNHKTSESKTAMVATRSRGQNQNQNENGATQAGDKRAAPASKKQPASKKAKQEKDGKLELGEDGEVGLKQQGKEEQTEQNGKEVKEGDENDTKVQQDKAEIKRSGQGETTQTGDETGVKDQGSSSGAELDEPKHGTLETGHIYFLYRPKIDADEVESIDDVSKFHILLIPTSAPHKKGHFHRIIEVGKKKLPDPGAKHQVIWGLVGAVGSDRSALKEAFGAYDYDTKTKGRRHQPAARPAARGHYILHSPRDELADSPEHDRQRDFKLLLAYEITTPVHEDFGNVQKELGLEPSGAIVLQIKNPDAPNTNPRAASIPKEKRASYPEKLNGLFHGRRFIPANPPAFLNYQGGELLIISSPHELSDSLGKDGEQVEADLEKDAEKESVGIKEALKELGMTEKDTDIEALEGAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B051</accession>
    <name>A0A1Y2B051_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_468557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B051"/>
    <dbReference type="InParanoid" id="A0A1Y2B051"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF172">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="206"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="401" mass="46275" checksum="F5A9358D50BF878B" modified="2017-08-30" version="1">MTSNKFNPPAADLPGKPSIPDWVPPALTKEKLDFAKLRTIDLSLVESDDPKVVDELVQITKKAIREDGFLFIENYGVSLEQLHRQFTLAQYLHYNISEEDQERLLFHPEISGKWAGYKHPWGFKRERKVWDGITQFNWYSEEWADYSRVPTCILPFMDEIRAFNEFLSESVNRRILILLSKVLELPENYLWDKVQSHGGPTGEGYYRHALFRPFTEEAEKLSKGLRFNGHCDYGTTTLLFSVPVTQLQIWGQDEVWRYVPYKPGAIVINIGETLEIVSGGHFKATRHRVFKPPMDQINAERLSIVQFNSSVGDLRMTPAIESPLIQREGFADYQGAFREFQKTMASGIPIPTNRQWREIQIAETVNTTDVKRQTIGGDWVMHDGKLMNKREFHGVTVILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0K1</accession>
    <name>A0A1Y2B0K1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_505890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0K1"/>
    <dbReference type="InParanoid" id="A0A1Y2B0K1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="387" mass="42295" checksum="BAA990D98BD2854A" modified="2017-08-30" version="1">MSTSSNPVSFSFEEGRIDVRVNENSADGTTDVTFRVNSSQSSSQLNTSSQHGTLEHSIKIHPTQHHFTAEEVQSFFTERQVAASAEEIDKSKAILLRLSQDKADVEDFIGKFISQYDEALRVGEEVVQSAIDAHCSERRAQNTSTAPCTGGASQTDEAECRGSAGGNLTNQEENEGGGDEIGQLIIFQSHPQTSQHPVHSLSMSMSSSLTSLSPSPENVQSPPETILSTNFDNGILSVDLVTQGDALKLHFKVRIPANDRNEDYEISSTEDGHITASQVRSFFNEEPRIKLTEKIASVQVYSQLLEDILSEREEHRKVSEKKLKEAIVHFSSASGVQSTSTAPNPSSGSLLSGRSSQMEGICFAREIMNAMSTIQRQNAENPPVRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1B6</accession>
    <name>A0A1Y2B1B6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_215641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1B6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1B6"/>
    <dbReference type="InParanoid" id="A0A1Y2B1B6"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF2">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="150"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="450" mass="49892" checksum="5BFBD6688942D7E8" modified="2017-08-30" version="1">MVQAGTTQVGGRVGIVGTGHRARMYTTAVSERPDSQLVALCDLNSERMKHHQKLLKDLGRPAATEYHPDDFEKMLDEQKLDVLVVTTVDATHHLYIVPALKKGIRVLTEKPMTTDVPKCKLILDTVEETKGSLQVLFNYRYNPVHWKVEEVIASGKIGNVKSVHFEWLLDTVHGADYFRRWHRYKDKSGGLMVHKSSHHFDLVNFWINAKPKEVFGMGSLAFYGAENGAKSGWARDYYRARDSEAASDDPFAIHLEDEPGLKALYADAEHVDNYHRDMNVFAKDITIEDDMAVLVKYNTGATMTYHLTAYSPWEGYRVMFNGDKGRLELEVVESEYRVPTKKGGAADGVVHGEKALPQDGGAKITLQPLWGKAEKVPFQVGVGGHGGGDERMLDQIFGPRPGQVEKDSAVTRLSANQVDGALAMAVGLAANESFKSGKLVKIDDLLGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B315</accession>
    <name>A0A1Y2B315_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_534834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B315"/>
    <dbReference type="STRING" id="71784.A0A1Y2B315"/>
    <dbReference type="InParanoid" id="A0A1Y2B315"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="393" mass="40816" checksum="6BF14F88EFEC685E" modified="2017-08-30" version="1">MIRRKLSNGLLRTAAQAQHSAISPAKVSSSVPLTGQSANLASAVMLSTTRNWKVETTTTLKAELKRRGLSQVGNKTALIDRLSSAETSASLGPVPPLPRKSSKQLSTTSSRALPPKRSASPARKARTETQGQDQDQEPVTSAGPPISSQKTDAPSAEPVRAEQVTVAPGLPETADVGKTRDTLDIKMPQPEAEQPTTQSIPFVPDNYRSNALLETVDNAVKKAEEALPKVMTVASASTHPAGGPTHGVHSSSDAHTHEVSSTEVEETVGQTFGSFESTVSSLLSAPVKAATSAGLVPAVGWPKLKDDSKSAGEYKADPSEPLNEQEKTGAWALAGLVGLGLWLGGPSKKTKGKGKKSGEHQEGNASVVAGTKGDAKWEQASGAGIVGHGGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3C3</accession>
    <name>A0A1Y2B3C3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative MFS alpha-glucoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_467523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3C3"/>
    <dbReference type="InParanoid" id="A0A1Y2B3C3"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="572" mass="62883" checksum="4344CE700F75C9FF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B417</accession>
    <name>A0A1Y2B417_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_575573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B417"/>
    <dbReference type="STRING" id="71784.A0A1Y2B417"/>
    <dbReference type="InParanoid" id="A0A1Y2B417"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="125" mass="13868" checksum="4CAA50258364EF84" modified="2017-08-30" version="1">MSVHTGAKPFVCEEPDCGRRFSVSSNLRRHEKVSSCSSSHARSSRQPCSFISVPLLSADPSRRISSTVHPLPCMLRRQRLTQSTGLKTHTARPARLSHAGPPRLTSTHTPTRQASQHPHIHIQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5C9</accession>
    <name>A0A1Y2B5C9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_532211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5C9"/>
    <dbReference type="InParanoid" id="A0A1Y2B5C9"/>
    <dbReference type="OrthoDB" id="2574524at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32118" checksum="92403C612A968617" modified="2017-08-30" version="1">MVVKLGAADSFNSSGATIVPDPRHDDNTSPPNNVSNLSYARVLMPQDTLGRELESALGGGDLQNSQAAWELFQQIQNQADDTVPLSLTQSQSETLDFSSFLASQPSDNETTTDIFSNLQLDNPVQTPFRPLSSHSHRGSVSGSDYSYTTTEMSSTDTDGDGDSHMEFKVEWAETTSISPQSAISPHEAQGVSPSLLGGGGPAGEPLREDDKKRKEKLEHRRSINRRSAQKHRLRRKEELESISHTLALREARIAQLERDLAVAHAQSAQLLDLLKSQGIDLGSKMQTRGRGAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5W0</accession>
    <name>A0A1Y2B5W0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_530100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5W0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5W0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5W0"/>
    <dbReference type="OrthoDB" id="2564629at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY30229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29096" checksum="2492F59876FA2742" modified="2017-08-30" version="1">MSRGGFAGRGRGRPRGGIYATLAGLHADMGPGMLSSMEMDSLMKQPKKHNGMLYPPLESSSLATLPAPDEFEKIILDETAKLHTTLSAEGQPWRLAGERKVVGIEIESFSDRFALPPQAPTQAQTHTQTQIHISTPPPNSRSTTDLDSTALYLDKSMFPPSLWEAYFEDHSGGGAVLKRRKKNELSDGRKRTKMLGLDDDGQEMDDDPSSDLEASTHSSSVDDEFDFEDESDHQDYDANYFDDGERDDDDDGAGAEEDVGGTYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B655</accession>
    <name>A0A1Y2B655_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal L28e protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_598549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B655"/>
    <dbReference type="FunCoup" id="A0A1Y2B655">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B655"/>
    <dbReference type="InParanoid" id="A0A1Y2B655"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="4">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY30020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="161" mass="17751" checksum="74133E6F28C61D0A" modified="2017-08-30" version="1">MSTDLQWLLIRKYNSFQHKTANGPILSREKGNLLNLHSHKYSGLANSKVVSIYANPEGAITITKVKKDAKPNQVASARQHVTLRRSTGPRRANKIAAVETASKGYRADLRSAAVARISALSRVNARTANPPKTYPTKVRGSKASHFGFKAEEKEEDVIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6P8</accession>
    <name>A0A1Y2B6P8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_529359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6P8"/>
    <dbReference type="InParanoid" id="A0A1Y2B6P8"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="132"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="377"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY30356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="524" mass="56490" checksum="771CBBE85C9D5C5C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7E2</accession>
    <name>A0A1Y2B7E2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_529594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2B7E2">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B7E2"/>
    <dbReference type="InParanoid" id="A0A1Y2B7E2"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1196"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1208"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1228"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1265"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1291"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1300" mass="145526" checksum="6D810B8535A0F515" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7F5</accession>
    <name>A0A1Y2B7F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_528245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7F5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7F5"/>
    <dbReference type="InParanoid" id="A0A1Y2B7F5"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="29760" checksum="E6281372A6878886" modified="2017-08-30" version="1">MKIDGSTFIITGGAGGIGSAAGRSLVAAGASVALFDVVPEEVGNSAAKSVSPEGRAIYFRVDITDSDAVKAAVESTVEKLGNLKGCVHCAGVAIKRPWTNDVAESIPNFKKMLDINVLGTFTVNAHVADAINKPLNHPNGGEEHGPFWTTNEERGVIINFASAAANPYARVLSYGPTKTAVVGITKSMSDFLGPSGIRVVSISPSIVVSAMTANFSTYFSDDLLKHATFPRVPLTADQITPTIHYIIENVGVNGIDIPVDGGWRLVSSKAGLAGGEDPRSLAPGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7F7</accession>
    <name>A0A1Y2B7F7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_598252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7F7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7F7"/>
    <dbReference type="InParanoid" id="A0A1Y2B7F7"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="97815" checksum="D6535654F7B707FF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8J1</accession>
    <name>A0A1Y2B8J1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="4 13">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_593543</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="4 13"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8J1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8J1"/>
    <dbReference type="InParanoid" id="A0A1Y2B8J1"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000047">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="710"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY31016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1162" mass="127575" checksum="6433ED9E78B5AA02" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8P6</accession>
    <name>A0A1Y2B8P6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase</fullName>
            <ecNumber evidence="1">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_94052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8P6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8P6"/>
    <dbReference type="InParanoid" id="A0A1Y2B8P6"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF91">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="2">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="160" mass="17280" checksum="D5584113478EA8CE" modified="2017-08-30" version="1">MPGETSPYGTVVNPGVLAPFHQHLFSIRIDPAIGGLGEGNTVMQEDSVPMEYDPTSPPKNNPYGVGYTVKKETIETSGWADAAPEKNRIFKVINPGHINPISGRPIGYKLVPVPSQLMISHPKSVGYARAELYALLSSVTRMIIADICCSANHHIVSITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8Q7</accession>
    <name>A0A1Y2B8Q7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_526838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
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    </dbReference>
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    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
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        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="649"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="172"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="431"/>
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        <location>
            <begin position="584"/>
            <end position="623"/>
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            <begin position="1205"/>
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            <begin position="9"/>
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        <location>
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        <location>
            <begin position="1231"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY31203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1300" mass="137221" checksum="9621272EC488C4BF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8T7</accession>
    <name>A0A1Y2B8T7_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_587588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
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        </location>
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        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="174" mass="18895" checksum="ADAE2472E1FDE367" modified="2017-08-30" version="1">MSTESNGDPSNASGAAFSGVPSIVLSFTVPSELHPRGQIEVWLYGDPSSLPSNTNLNTSETVSGSEEEGIDLGTRELNTRFDQRLNELASGEFGDDPTELFFQAPPIVGEFIREAKSQTQLTKLVEHLISKCLWNKELYQESVDSRMRQLGGSDGESQDRMTGDSGTECNTSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y2B9B7_9TREE</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">BCR39DRAFT_479985</name>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:U2-type spliceosomal complex"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
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        <property type="entry name" value="CWC25"/>
    </dbReference>
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        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <end position="192"/>
        </location>
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        </location>
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        </location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY31354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="440" mass="50894" checksum="551356AACAC84FDD" modified="2017-08-30" version="1">MGGGDLNMKKSWHPVLLVNQERVWKAEKQANEEKKKLAQLRKEQEEERQLAELQRMQEASTGRKRVEKLDWMYSAPSNEGNALGGARIGEREMEDYLLGKRRVDEVLAQGDKNVGSLHKEFIAVQNANSARDTASKIREDPLLAIKRQEQAALAAMANRPDIRRQLKALKKEAGESKEERRARKKAEKAARHESKRHRYRDSRSPKSEYTDEDDKRRVRDYRDRDEKKYRARSRSSSPRRDKVREEGSQRYRDQDRRYRDESPGRRVRNLSIGDRDSRNRSERDERRDSGDRSRDRHSNGHSRDDRIPPPRQYPTTSDSREVKPHPSRPSAMDLAERPTSSRPSAQPPASNGNGNSNHLDEMRAARLAAMSQSATELYAQRTKTLSSMAQVEKEELAREERMRTKYGQEHVAAGFFKQKSEMGLGENLARRAGKGLQRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAN6</accession>
    <name>A0A1Y2BAN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_525825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAN6"/>
    <dbReference type="InParanoid" id="A0A1Y2BAN6"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="29"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY31590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="578" mass="62498" checksum="8CDFD5647936F245" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAV3</accession>
    <name>A0A1Y2BAV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_525927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAV3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAV3"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013028180" description="Pali-domain-containing protein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="20653" checksum="E673BF1E5DAC744A" modified="2017-08-30" version="1">MVSPAFPGLFFSAAAAILLLFASISPPAWDRVDFLHASVGSSETVFGVFGECVKGGSCSTKSVGYDLVLNGATGVTINETVLHNLTYTMILHPIGGFVALLAFVFGLLGIACASRTATVFMGLSAFVASVITLVVFVIDMVLWNIVKNHIKNAGYSATLGNANWFTVAALGSLWFATCASCCGAFGRFATGRAAGEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAV9</accession>
    <name>A0A1Y2BAV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_524797</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAV9"/>
    <dbReference type="FunCoup" id="A0A1Y2BAV9">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAV9"/>
    <dbReference type="InParanoid" id="A0A1Y2BAV9"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY31959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="339" mass="37913" checksum="E976EF5F39193BB1" modified="2017-08-30" version="1" fragment="single">MPGSRSHLRLRDIPALPLLFLLHILFTLLSLLLRTYQLLTSPRPLKTPASFQRPIRHIAVVLRPSTSSYDVKVRQETLALKESVKRVVRWASEMGVSEVSVFDGKGLLQNCQEELVRDLLRLPPSPPGSRPATPARLPNAVQASSVSKPRSRSSVQTIIIPPHHSQGNESEMLKLHVLAPSTRDVVADLTASYIKKQIPLGDIQQDMLDRDVRDVLHLSHDPDILIIHLLSSPSFFKALLPRPAPQLSGYPFWCLRITEIYQHPTPLPRLIPPPLLSLLHQARTSNLSLLRKVARSLPLTDPDESETIHGSRRVIKGAMGREVWDGAMRAWGGVEQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAZ0</accession>
    <name>A0A1Y2BAZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_527143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAZ0"/>
    <dbReference type="FunCoup" id="A0A1Y2BAZ0">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAZ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BAZ0"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="134" mass="14544" checksum="B263F71129689163" modified="2017-08-30" version="1">MASTSRASAHRIGSLLFCPACGTLLDLPKDDEDEIACAQCGRLEPSSSYENLPTKTYSSPTAFPSALRSKRALVQDQLTDGERAKEKDPVAQEKCQKCGNIGLSYKVMQLRSADEGSTVFYKCLKCGDQTSVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAZ9</accession>
    <name>A0A1Y2BAZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_557944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY32021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAZ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAZ9"/>
    <dbReference type="InParanoid" id="A0A1Y2BAZ9"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="745" mass="79255" checksum="709157D16E297406" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB94</accession>
    <name>A0A1Y2BB94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6 12">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_524166</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6 12"/>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB94"/>
    <dbReference type="FunCoup" id="A0A1Y2BB94">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB94"/>
    <dbReference type="InParanoid" id="A0A1Y2BB94"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000001">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="15">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY32102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="384" mass="42673" checksum="02363E26DC76EDDB" modified="2017-08-30" version="1">MSGSETKYDIPQLAGIETWKDQTWPELKNDLLLRAARGEETPRAPVWVMRQAGRYLPEFQEIRRDHSFFECCQTPSIACALTLQPIDRYPLLDASIIFCDILVVPQALGMEVLMEPTKGPVLPSPLVTPSDIERLRTTVDVQKELGYVFEAITLTRKGLAGRVPLIGFCGAPWTLMAYMCEGGGSRTFEKSKSWLYKYPKESKALLKRIADVCADLLIGEVLAGAQMLQVFDSWAGELTPYQFETFALPALLHVSHKVKSVLAQLGHPTITITLFPKGVHANSSLRLLADPHTTGYDTLGLDWALDPVGVREIVGDKVSLQGNYDPVVLYGGKEGIESEVKRVSERWKEAGGGWIANLGHGITPAVKTEDMGWFLECVHRYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBE0</accession>
    <name>A0A1Y2BBE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_479328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBE0"/>
    <dbReference type="InParanoid" id="A0A1Y2BBE0"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="433"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="950" mass="103268" checksum="36F73BA54F9F15C8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBV6</accession>
    <name>A0A1Y2BBV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_523889</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBV6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBV6"/>
    <dbReference type="InParanoid" id="A0A1Y2BBV6"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="13">
        <location>
            <begin position="115"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="390"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="510"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="541"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY32313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="600" mass="68176" checksum="849067F74117802F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCP1</accession>
    <name>A0A1Y2BCP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_82579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCP1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCP1"/>
    <dbReference type="InParanoid" id="A0A1Y2BCP1"/>
    <dbReference type="OrthoDB" id="2571149at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="331" mass="38082" checksum="2E3EA6A6644D04DE" modified="2017-08-30" version="1">MPPKTNRITTLTAFKPVYPRRLERTVRPRPKLTSNILPFHRDPAHTIPTKWNLYRSLLRSASSYRPPSSGESSSGLTAVRRKIKETWRRFRGMTSPSQTRVILDRQYTLLDKIRSSDPQLEELDKFYTKVYAIRDTPKAPVPKPIPRLTGGFLFPTYHNPPLPKLHPQPPEISGMIRQRIKARAKIIDKLRRYREWGEDMTTETKFWQRINAVKKSGGDGGGVGGVGGGEGKVADHWTGGRFTWSREQDEHLKPIHESMEKYTARSKMMYDEKTIEKVLMARKVRARVANEMNRKDNMEKRKKQERDQRGELALRESAPGPKTARGAAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCS6</accession>
    <name>A0A1Y2BCS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone reductase complex 1 MLRQ subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_522869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCS6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCS6"/>
    <dbReference type="InParanoid" id="A0A1Y2BCS6"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF1">
        <property type="entry name" value="GEO09626P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="88" mass="10399" checksum="3D9C91B1C9C7D3B7" modified="2017-08-30" version="1">MAARFNFKKNLPVEVYPIVAIMGIAVGGASYYLYKLAMGNEVVWDRKGDWKPWDKIKYDQNTKFLTTQPEFWAKRKEQRLALEKERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD88</accession>
    <name>A0A1Y2BD88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_374879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD88"/>
    <dbReference type="InParanoid" id="A0A1Y2BD88"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38683" checksum="6F760A8B2FD9A8B6" modified="2017-08-30" version="1">MDDRLDFLATYAKDGEEVRHLPIECTFPHRLDGLGGGETAMHYWPSKNTDGPPEQLTLFILGNPGSLGYYPPFLNHLHDLLPPTHALLAMSHVGHSPSLAAPQVPLTLDEQIDTKIEVVQAIRSTLDELAIDEHLETGQALKSPRLALMGHSVGAYILTRVIKSLNGDGIHAGYMLFPTVGWISQSWNGKTLFPIFHQPLRSLLPVLSHLIRPILPLTTFPQTTLDLLYSPRTIQHTLALAKSEMETIRQPDLPWFKTNVHKDPTRGLFGVWSGGNLDGWVGREGAMVRECLGGEWGGRVRVLDGVPHAFCLSQAHSEIVAEVVASWINPLQAGPRGKTSVAPPYGSTKLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDP8</accession>
    <name>A0A1Y2BDP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G protein-coupled glucose receptor regulating Gpa2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_523162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDP8"/>
    <dbReference type="InParanoid" id="A0A1Y2BDP8"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46075" checksum="A7026C3544B48EA5" modified="2017-08-30" version="1">MSRMSSIGPAASGVSGEPVTDKGCESPGFLLATALWWQYGFSLAIAITTYVALRHPLSSFKVAAEKRAVEIIVLIVVIGILQAVLWRILRGFEVWEDFCFYAPPSHLAAELLQFIPRITVSLIVISIYARLVSFLNRPDLSSAYLPSPQLQQTPSTDPIPPWERMTIPDFSTLEADGAVRGRPKSSGGASVASLVRVFGNRRPVSAGSTWFTGAETELKVEIHAAGVETGLELKVEIQTVEPALTRSRASSQTMVVTELGSLDEFKLKPEQDTDHLSIAETLHTTRDDPEVASFRGMLDYIPTHSTTLYQSPSMDAIPRPSTPDEQVESMASFMNRQMIYYIIWFPLTHLTICGMAIFRFVYCETTGKDGPVMQGLTLVMIMGQGIADIIIFGFVERRTQMAYKNEIAACSPGTDQGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF14</accession>
    <name>A0A1Y2BF14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphatase phospho-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_519901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF14"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF14"/>
    <dbReference type="InParanoid" id="A0A1Y2BF14"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="252" mass="28382" checksum="8FAE6DE974EF0FFE" modified="2017-08-30" version="1">MTGKQLVVFDFDWSFVDQDTDRWVFEVLSTKHRRLLQDRKSGGGTGIQCTPDVVDQTMGDLAQAGYTKEDVLDALRILPLHPAMKRAVLGLKERKPDTVFVCISNSNQVYIQTILEKHGLTTLFDTIITNPAHWSTSPIPNRLHVGRRLAASEPPHGCTIGCLANMCKGAELDTYLASHGGRESFERITYVGDGGNDFCPLLRMRTGDWACVRTPGFELEERIKNEGEKAGLKVDVKLWDQAWRIDEYFQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF17</accession>
    <name>A0A1Y2BF17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_563941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF17"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF17"/>
    <dbReference type="InParanoid" id="A0A1Y2BF17"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="132"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="476" mass="51726" checksum="C527D9B06C72F313" modified="2017-08-30" version="1">MPHPIPGHVIRESLDRRQSDSSSLAEEGEATPLLGEDEDGMIALKWYRGPLFIAGLKFAALFFVFTAVVVGTFWFGLPKLEPEDRVVLKLPRSFADLQALNSLFQKYKTRYPLQILACGVVTYLFIQMFTLPGSMYLSILFGAAYGMVYGLLLACACDAFGSLLCYTLSAICAPPLLAIPFYRDRVETWRIKIMGDPASGKQVSWDGVFAFLVVLRIAPFPPHWIANFVAPHLGIHPAFFWASCFVGIAPVSVIHVTIGMSLDTMTSAADFHILSLRNVLGLIAVMVAVLIPVGLKRVFRKDLGELEETASETESIINGPIMDDVDVPVPAYPQISPGTYRAVDSGLVLAGPSSGDPNLDTDTDYIRAPSSKIGIKGKGKGKGKAKLLDVIVDQDDEEDEGGEERRRYEIYDPHSRSEHVVLPSSNSGTVNEKRRAGYAPFRGYGAIESVPIVGGVGVGGGGGRGERISGIWPFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF69</accession>
    <name>A0A1Y2BF69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ataxin-3 homolog</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Machado-Joseph disease-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BCR39DRAFT_586533</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Forms a complex composed of deubiquitinating enzyme atx-3, adapter ubxn-5 and cdc-48.1. Forms a complex composed of deubiquitinating enzyme atx-3, E4 ubiquitin-protein ligase ufd-2 and cdc-48.1. Interacts (via RRDR motif) with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus); the interaction with cdc-48.1 is not required for atx-3 enzymatic activity. Interacts (via C-terminus) with ubxn-5. May interact with ned-8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF69"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF69"/>
    <dbReference type="InParanoid" id="A0A1Y2BF69"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000018">
        <property type="entry name" value="Ataxin-3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="21">
        <location>
            <begin position="29"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="398"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORY33469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="496" mass="54685" checksum="BD934D0D7B49B97D" modified="2017-08-30" version="1">MHIAGPPPPAGIDNDLARAREATVKMDLVPYMYYERQEPGSQLCAQHCLNNLLQQFTYTEFDLADIARKLDQAENAALSRDNQNKKSFNYNDTGYFSISVLERAMQVWDLTLVRWRGEAMKPYQEHPEDQAAFILNLASHWIPLRRFSPYPPNKASNKRWYNLNSFLPNGPEWISPTYLRMVLTQAEEEGYSVFCVRKAGKGAGEGMDTAEGLGWGDGGIGILPECQADHIALELGEPLGRSGGIASPRSVSNEASTSRAAVAAINPDQPTVDASITPPTGSGSPPPRRRHRQEDLVDSAAPSEEASASPKSPQRPPRNPLRASMSSLERLAASTIQPTDPDDNGDVEVDDLPIDAEEYYRSRHREEATYGGPTDFAYHSRSYDDEDTALQAALKASMQDVPSDWVPPALEPKKKPIRKISETKPVPAPVPVPEPVQELRGKPVTPTRPKAEGSRRNSGAAGSRFVEMDDDDDDEPTESLSPGEIRRRRLARFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFC1</accession>
    <name>A0A1Y2BFC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_463658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFC1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFC1"/>
    <dbReference type="InParanoid" id="A0A1Y2BFC1"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="95" mass="11575" checksum="794BE21238B37FA5" modified="2017-08-30" version="1">MVYTIVVHLQAYPDCIEKLRFKLIEASAIYRKDKETIDWYVMQDPVDPTKFCIVERYEHESSQKYHLENPYWKTFDPYVVPLLSKPMDLTRWEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFZ8</accession>
    <name>A0A1Y2BFZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_303530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFZ8"/>
    <dbReference type="InParanoid" id="A0A1Y2BFZ8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="125" mass="14403" checksum="F1C530E140356A76" modified="2017-08-30" version="1">MAFFGSDGLENTNKQLTKQLASKNAELAFMKNERDTRARELSEAKRTIEVLEARNEGFELERERWESLKDGKSGPVEVRISISVLRCFHWTERPMDFVGPQFPFHQSCLISTPIQPSSLTLTYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG19</accession>
    <name>A0A1Y2BG19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_520797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG19"/>
    <dbReference type="InParanoid" id="A0A1Y2BG19"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="80" mass="9211" checksum="C73FC42710525FC2" modified="2017-08-30" version="1">MTLRTNAPFIHYTLNNPTLAHAYHSYTHYPVNSTIFTVRSTIFTVKSTTMQTSQTIRAKPARPTIHTKLDVRGRKSHRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG41</accession>
    <name>A0A1Y2BG41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG41"/>
    <dbReference type="InParanoid" id="A0A1Y2BG41"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="236" mass="25789" checksum="81EF6284D7E4829F" modified="2017-08-30" version="1">MTNTAIDLPNGSNSTSSASEDLSPFTTTNYRESLFTGLTLNPESGFSSLISPSGSPRPSGQALSVTNTSNHSLPLTRPNTPTSFSNDNSPTTSSRSPSPSSGQAPSETSPPYRILHSHPDLKDDELENLAIVRRYMKDCWSTMFGQDPSVNEKVMARNSLDGLRTRLKQVRETKSQGTGGNEFVDGEKEAEAEHLKEAEAEHLKEMDSIINELGNILRYSPYIEGEEDEGSDDERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGQ8</accession>
    <name>A0A1Y2BGQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_519164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGQ8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGQ8"/>
    <dbReference type="InParanoid" id="A0A1Y2BGQ8"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="2">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="376" mass="41478" checksum="5F707A602FB18210" modified="2017-08-30" version="1">MSSTGTIYPSAKRHTVLVLPFTTYVFTNPTILLPVIFATLAHSSYDSLTVVFSSPPEPAQLYSLLKADAVTHWEAFQEFLGKVYATLAAAQWRSGRVLMNVEVHFDGEEGDWKEKLPPKNADSQTVILEGFSDLPINPEIKALLPGITSKIPHRAFPSLAPIIPSHDPGLPVIALGGTFDHLHAAHKLLLHLALFLTTRRLIVGIMSDSLLASKSNAKLVQPLSVRMDSVKRFLSRCGMGNVEMDVVEIHDPLGPTGWEKDIQGLVVSGETRSGGEMVNLTRQERGLGELQVFVVDVIASQTVDQQDQEDDLEVEKEDDDEGEITVRPRDRSESVMTLDLRSEVDEKRLKDLKLGSTAIRQWIADRGSHGDDSMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIG2</accession>
    <name>A0A1Y2BIG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_513402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIG2"/>
    <dbReference type="FunCoup" id="A0A1Y2BIG2">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIG2"/>
    <dbReference type="InParanoid" id="A0A1Y2BIG2"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="247"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="398" mass="43538" checksum="A27A9546E96A9C4D" modified="2017-08-30" version="1">MSNPYLPSSPASPFSSAGAGPSTQPITRSRTLFYLSIRDSSAPSYPQRQRRSHVQYGDTIDVAEDDQEALLGGGRPGDVSVGTKGLPPRWVDASDEVEEVLEKVKGKIATLDKLHAKHVLPGFTDRSAEEREIERQTADITRDFRRCSTLISSIQPGPRAPRVEIMTSKNVQRGLAQKVQDLSGQFRKKQRVYMQKLQGHAVKNKDLLAASGAISLRGSDSIDELAEDEHASTTQLQSQSQAQVAVNIDIDQRTKEITQIATSIAELADLFRDLGNLVVEQGTVLDSVEWNVQTAAKELSAGVEELKVAQRYQANTGRRRCILLLVLIIVGLIIVLVYKPRGGPNTISPSPVLDDDTTSKTSSGITIPAPSHTRRPHRPHLPKPSKMPAIPIGDDNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIG6</accession>
    <name>A0A1Y2BIG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class III aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_116321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIG6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIG6"/>
    <dbReference type="InParanoid" id="A0A1Y2BIG6"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="463" mass="49472" checksum="FA4EC873EEF96DF4" modified="2017-08-30" version="1">MSPIALPTLPTPPLSPPSFTSKVTGSALLHHATPQPVATSASSLTFTLQDGTEIIDGVGGAAVACLGAGNTEIVQAMTEQATKLSYCYHQLMGNEPSEQLGKFLCDRSQGAFVSAAFLNSGSEAIEAAIKLCRQYWVEKGQPQRKYIIARFPSYHGNTLGALAVGNIPARRDMYTPLLSTTAFHHVPSPTYLRSHLPDESETSYSARLASELDAKIRELGPENIMAFFAEPVVGAALGVMPPPSGYFPAISKVVRGHDILLVMDEVMSGMGRCGSLFAHQAVAEGIKPDICAIAKGLGAGYVTISGILVGDKVQRVVKQAGQWKSSHTYQNHPINCAVALKVCQIVERDQLLQNVRQRGDQMRAELRDGLKGVQRVFDIRGKGLFTGIELDAPSSLSPRFAARVKEKCFQNGLLILGLSGTIDGKEGEALVIAPAYIISAEQVSQMVSVLVKSIKASVSELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ12</accession>
    <name>A0A1Y2BJ12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_513249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ12"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ12"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ12"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="229" mass="24743" checksum="73B7376B0D229231" modified="2017-08-30" version="1">MLGREEAFASEGKKIVAIGRSYTYNWPGNRVPKPLPEPLLFIKPTTSYILDGQQVEIPQNCEVYHEVELAVVIGKKGKDIAEDKAYDYVSGYALALDMTARNIQAKAREAGLPWTICKGMDTFTPISSFIPKSLIASPSNVDLLFTVNGIVRQSGSTADLIYSVGQLIAFASSVMTLEPGDTILTGTPEGVSRIMPGDRIFASLSVSGSELASLSVDVVQKTTGYKFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ22</accession>
    <name>A0A1Y2BJ22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_514697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ22"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ22"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ22"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF2">
        <property type="entry name" value="OS05G0199100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38147" checksum="6280B3666CC9C51E" modified="2017-08-30" version="1">MTRTADPPRLRDAYKKTQAVHSLSCLHLTTITTTMSRYENRYDDPYDRPIAYPPPEQYQQPAYAQDDPNAYHDGAYGEAPRYPSYPADPSAGDYEAYPSTEKINDGGYAENTAREQPGRSGVRGQTKSFASLGPPPRSTGILRMWRKDERGEQWFRGGGLRATLRIFGCCLTITIIMLVSIVLAIALYVRPPNVTLQSVNLGNSPVTLTTDGLTVSFNVTISAANPNWFSVDFNEIKATAFYPGNNTNSFGGGTLYNVDFQGYNQYTFDFPFTLNYTTAADPNRVVLNDLISKCGILSGVKSDITVDYDLLLKLKVLGVSISPTVSGSASFECPITESDLEGIIGSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJC6</accession>
    <name>A0A1Y2BJC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair metallo-beta-lactamase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_514011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJC6"/>
    <dbReference type="FunCoup" id="A0A1Y2BJC6">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJC6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJC6"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="8">
        <location>
            <begin position="428"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="719"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="886" mass="97851" checksum="7A798FF6474310C7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJE1</accession>
    <name>A0A1Y2BJE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_515439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJE1"/>
    <dbReference type="FunCoup" id="A0A1Y2BJE1">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJE1"/>
    <dbReference type="InParanoid" id="A0A1Y2BJE1"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="108" mass="11998" checksum="1ADBD1D4E85E8D64" modified="2017-08-30" version="1">MPPQVKSKAQKAAAAQAGSKAGKKKKWSKGKVKDKANNAVILDKPTYDRIIKEVPTYRVISQSTLIDRMKIGGALARRAIAHLEKEGLIKRVVHHRAQLIYTRATVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJN8</accession>
    <name>A0A1Y2BJN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_515962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJN8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJN8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJN8"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="681" mass="73047" checksum="81618E8DBABEF9C4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJV9</accession>
    <name>A0A1Y2BJV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_516451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJV9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJV9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJV9"/>
    <dbReference type="OrthoDB" id="5392202at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30877" checksum="BF3A60375D37B294" modified="2017-08-30" version="1">MSIKLSPALKSLISAPHAFPAALPAPPRQALNELFDQIRRRAEPYGVNADTWLTLGTAGIMTVNSPDSLCALWDFASARRDNQEGKIRDALIMRETGLKCISFNGIPRTINNLGALHTHQTKEFTDHLPTTSYRTPDASNLAEISTRGRALWNNIYSPHHEKLLSKLGQSHPDLPVHILNSHYGPLLSDPSTPGASIVGRLLTSIVAMTCLRLQTGVGLQVTSHVYGLKKALTEGNTAEKEVAGAEWLTSDEGVTWVLESADEISRVVAEGQTSFGKTLQKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKT1</accession>
    <name>A0A1Y2BKT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L22/L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_509224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKT1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKT1"/>
    <dbReference type="InParanoid" id="A0A1Y2BKT1"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="212" mass="24265" checksum="C1F2BED23D4A559C" modified="2017-08-30" version="1">MRRRSDEEEETSTSPTSTSTSGSGSDKPDGTSTDSTESTESIFSEVSKEITQYNKHYRWRGPKEHRFKTAKHKISPRKLNDLGKQIAGLPIDEAILQMQFSEKGASKWIKSTLALARDHAEMKGLRRSRLQVEAAWVNKSRYGQKLLDIKGRGRQGIKRHPYARLCLLLKEGKTRVERAETRFVKDLGKVRSAGLAREDGKLRRQHTKQWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL41</accession>
    <name>A0A1Y2BL41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_509977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL41"/>
    <dbReference type="FunCoup" id="A0A1Y2BL41">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL41"/>
    <dbReference type="InParanoid" id="A0A1Y2BL41"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42019" checksum="506A5DD107521AA6" modified="2017-08-30" version="1">MPLNETSTTAKPESQIISDDSDDDEPGFGLDDLIPEPESPTPAPYSFSTYIPPPLPSLPILDARTQLILRLVGSHPLWGHHLWNTARTLTDYLMENPQLVRGRKILELGAGAALPSIVSLLIGAEKAVMTDYPDTQLVDNMLYNVETNLPSALVERADVEGFTWGRDPGPLLDKTHGEGYDLLILSDLVFNHSQHPALIRSVNSLLRDSTSKPSPSRPDSIVPTSRKSPPLQQQQSPPLQQQQSPPLQQQQSPPLQRQQYPPEQHQQSPPEQQQSISHQRSSPEERQSPQPPPPTYPSILVFITHHRPHLISADLNFFPALASSGHGWAYQRIVERFAGVMFDEDPGDAIVRGTVYGWRCWRVRTELGELPGEVVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLA9</accession>
    <name>A0A1Y2BLA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_515455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLA9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLA9"/>
    <dbReference type="InParanoid" id="A0A1Y2BLA9"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="367" mass="39371" checksum="9C93BAFA79D303F4" modified="2017-08-30" version="1">MVIGRPCSACWATLSANRAVYISRRSTLRQFSTSSFSRSHENPLGIPVRNPNPAPTLPRRGGPPLKSRIRGVKRVVVVASGKGGVGKSTVAANLALSLVQTSSLPHPPRIGLLDLDIFGPSVPKLMGLENVGDPQLSAENKLIPLQNHGIKTMSIGYLLPPNPAHDSPVVWRGMMVMKAVQQLLFDVDWTTSNEDLDVLVIDMPPGTGDVQLSLGQLVAVDGAVVVSTPQDVALVDARKGVGMFNKVSIPIIGLLLNMSHFTCSTCSTPHYLFGSATSFEKAANDLHLPILGKLSRYQYQFQVLSFNGLVGKVPLVPSVSDGGDAGRPVMVQNDLQGQEVRQVMGEVGREVWDWLGHRPISEAGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLY2</accession>
    <name>A0A1Y2BLY2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyridine nucleotide-disulfide oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_461277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLY2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLY2"/>
    <dbReference type="InParanoid" id="A0A1Y2BLY2"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="30"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="8">
        <location>
            <begin position="394"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="464" mass="52000" checksum="9420DB09F96C5361" modified="2017-08-30" version="1">MSNRTIGFTCTHLGSRLRAFSTSSRLSQEQLVILGSGWAGYNIARQIDKKLYDVTVVSPNSYFSFTPFLASAAVGTLEYRCATEPVRGIKHVHFAQGWADSIGNPTPLQGPSKLQTPEEEGEEGNKEDSVQRLYEIEYDKLIIAVGCYSADFGIPGVAKYAHFLKDIRDSRSIRNRILERLEQAVLPNTTTQQRRDLLSFRVVGGGPTGIEFAAELNDFVEEDVYRLYPELKNLVSITVYDVAPGILMSFDDSLRNYAEKHFRREGVKIKPNSRITAVGEDWLELDGKDRVPHGLLVWSTGLASNPLMSKLAGVKRDEKNKSIRVDQHLRVINTSDQPMSDVFAVGDNAMPEEGRLPATAQVASQMAKNLSKKLNAMGRGTDLNKTEAFTWSNRGSMVSVGQHRAMVDRSQDSIQGPKSRLAGISAWIVWRSYYMTLAMGWRNKILIPVHWALTWFFGRDVTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BME4</accession>
    <name>A0A1Y2BME4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_512031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BME4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BME4"/>
    <dbReference type="InParanoid" id="A0A1Y2BME4"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="193" mass="21852" checksum="E340E10FE2369BE8" modified="2017-08-30" version="1" fragment="single">MHVYKLSDGVIEKYSRRLDVINRGFGGYNSEWARPLFDKIFARKEDAAKVPVVRLVTIWFGTNDSVLPVKEQHVPLERFIDNINYFLTSLTSHDSPYAVADTPVSIILITPGPPLHSQMGYSQMAEPKPHFRTIERTGQFRDAVLQIGNDWKLKEKEQNLDPRGRGWKVETIDLWAALEKAGGGLGEGLAPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BNE1</accession>
    <name>A0A1Y2BNE1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_555813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BNE1"/>
    <dbReference type="InParanoid" id="A0A1Y2BNE1"/>
    <dbReference type="OrthoDB" id="10690261at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="690" mass="77283" checksum="85C200B3F778EABD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE35</accession>
    <name>A0A1Y2AE35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_555255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000132">
        <property type="protein sequence ID" value="ORY20537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE35"/>
    <dbReference type="InParanoid" id="A0A1Y2AE35"/>
    <dbReference type="OrthoDB" id="2565099at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="616" mass="66445" checksum="9499A7F144B861EA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE93</accession>
    <name>A0A1Y2AE93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rad17 cell cycle checkpoint protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_555112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000130">
        <property type="protein sequence ID" value="ORY20600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE93"/>
    <dbReference type="FunCoup" id="A0A1Y2AE93">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AE93"/>
    <dbReference type="InParanoid" id="A0A1Y2AE93"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="733"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY20600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="783" mass="85436" checksum="C46EED5803A89F6B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF67</accession>
    <name>A0A1Y2AF67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_554110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000116">
        <property type="protein sequence ID" value="ORY21229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF67"/>
    <dbReference type="InParanoid" id="A0A1Y2AF67"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="377" mass="42354" checksum="E0D07A9A1346D6DA" modified="2017-08-30" version="1">MTSQIPSDVLLAINRIHEFAEATGHKRSRSTTAVDARSHCHECQSLNVLLSQKDEVIRQQSALIAQQSLLLNSLSTARDNGPLSALKATHPGSHNFTDDIKRLQPFLLEQITSLTPSFSFYSSAFTWPDPLVPPPQDFLHFNPPTPWAPFILGSDVNMLDFLLDFTATSRAATYAQWSRSGSEACLSLFDASTPPNIRFVSQSLYRESAYDLQSAADFLRAREIIASYTMLLPLVELDMIAGTIELPDGDVPWSVHPQTALVTVYGHVEISLVKKLFRPVLPEVTSRWEYVTKSLSNIPIDAAREYHQLLSLFLLECLVKDPKSCTHGLTRVYIPDPEDEDIHVSWQDLKAYLIKNFAGALYRHGAEVERLIKHLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFQ3</accession>
    <name>A0A1Y2AFQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-coenzyme A transporter 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_553650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000111">
        <property type="protein sequence ID" value="ORY21433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFQ3"/>
    <dbReference type="FunCoup" id="A0A1Y2AFQ3">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFQ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AFQ3"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="672" mass="72703" checksum="07F6FFB445A995BD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFZ6</accession>
    <name>A0A1Y2AFZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_553526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFZ6"/>
    <dbReference type="FunCoup" id="A0A1Y2AFZ6">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AFZ6"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="71" mass="8245" checksum="02286FB67BB2DE49" modified="2017-08-30" version="1">MSQQRYSQQNPNSMPNRDQPKAPEQIEYICGDCGAKTALKANEAIRCKECGHRVLYKPRTHRIVRIYPLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFZ7</accession>
    <name>A0A1Y2AFZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Proline iminopeptidase</fullName>
            <shortName evidence="8">PIP</shortName>
            <ecNumber evidence="8 10">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_55049</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="8 10"/>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFZ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFZ7"/>
    <dbReference type="InParanoid" id="A0A1Y2AFZ7"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="33"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY21523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="314" mass="35668" checksum="F7983B38DAE55958" modified="2017-08-30" version="1">MVYPQSLPFDEGYLKVSGIHTLHYMQFGNPDGKPVIVLHGGPGSGLVTFHTTFFNPNIYRIIAFSQRGSGKSTPLAETRENTTWDLVGDIEALREKLRVEKWLLFGGSWGSTLALAYAQNYPERCKGLILGGIFLAREIEAKWDLEGRRQLFPEAWDAYTSHIPPAERTDLMPAYLRRLQSTDHTIRMGAARAWNTWELAIGQLQSELGRLESMLNDEDWCLAHAVLEAHYFTHRCFLEEGQLLKTKNVDRIRHLPCSVVHGRYDVVCPPRNAWDLKGAWPEIELQFTPDAGHSFRETGTMKALVQIADRFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGG0</accession>
    <name>A0A1Y2AGG0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_457520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000107">
        <property type="protein sequence ID" value="ORY21641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGG0"/>
    <dbReference type="InParanoid" id="A0A1Y2AGG0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="108" mass="12218" checksum="F80B86CD815B23CF" modified="2017-08-30" version="1" fragment="single">PRQHLYTLFTEFLTSNDKNQVMVHAYTVETLALNEVVSFWGSLAHNGSITSPLEVYATSFERFDWVDLNDEDYFTKVPSCQRPMIIAQGCVEGPTTKDQFTLTGSVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGZ6</accession>
    <name>A0A1Y2AGZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_553514</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGZ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AGZ6"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY21457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="107" mass="11745" checksum="4A207B62B058A712" modified="2017-08-30" version="1">MPHKKVAIEGIKALTFYADRKTAARRTEAIPQLQCLGKPCSKFQPPVIQCINAGLDDMGGVQWRCDTDLPSGVRLGRTDVSCEGWSRAGDKNVLQGKRLSSPVDLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH82</accession>
    <name>A0A1Y2AH82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_474567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000113">
        <property type="protein sequence ID" value="ORY21335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH82"/>
    <dbReference type="STRING" id="71784.A0A1Y2AH82"/>
    <dbReference type="InParanoid" id="A0A1Y2AH82"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="363"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="489"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="778"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY21335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1030" mass="111339" checksum="67DE4D56F0D1979D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHC3</accession>
    <name>A0A1Y2AHC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_553326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000108">
        <property type="protein sequence ID" value="ORY21597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHC3"/>
    <dbReference type="FunCoup" id="A0A1Y2AHC3">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AHC3"/>
    <dbReference type="InParanoid" id="A0A1Y2AHC3"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY21597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="353" mass="38592" checksum="ED105041D0E8B5E1" modified="2017-08-30" version="1">MLQTNLLAPGHADLVTHLTYDFYGERLATCSADQHIKIFRRSVDGQWDLESDWKAHDAPLLRVSFAHPLHGSLLASCSHDRTVRIWEEPSGSSSKENRWIERAVLAGPRGSVRAVEFSPPNPSYGLRVASISTDSRLRIHTSLDPDLNDWSTAYDVHVPSLAAPGQSEDPPAPETNGTHDLALGGWGLSWCKEKWWGSVFAVFAGTSPVVKIIQADPTPTSLINLVPPSSPPVPLTSLAWAPSCGRSYHLIATGARDGTVRIWRVEPPSPPDESGNGYEDDQKRREAWSAEIVGEFGKGGARVGMVDWNATGTTLTTSDDDGVIRIYKPTYAKTWKLLGRITAEEPDSETNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJM0</accession>
    <name>A0A1Y2AJM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4 8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_550884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 8"/>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJM0"/>
    <dbReference type="FunCoup" id="A0A1Y2AJM0">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJM0"/>
    <dbReference type="InParanoid" id="A0A1Y2AJM0"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY22763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="134" mass="14590" checksum="96A1BC635FE7F622" modified="2017-08-30" version="1">MLRTSLRSITKNTLKSRNFSSTTIRMGVTVDTISPGDGKTFPQVGDTVHIHYVGTLQDGSTFDSSRDRGSPFITAIGVGRVIRGWDEGVPKLSLGEKANLTITPDYGYGPRGFPPVIPPNSTLKFEVELLKITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJN6</accession>
    <name>A0A1Y2AJN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-binding cassette transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_551500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2AJN6">
        <property type="interactions" value="32"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6500128at2759"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="entry name" value="ABCC_MRP_domain1"/>
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        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="188"/>
            <end position="205"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="234"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="435"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="711"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="1085"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="1211"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="1255"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1311"/>
            <end position="1329"/>
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    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="374"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
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            <begin position="790"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1080"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
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            <begin position="1397"/>
            <end position="1637"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="509"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="509"/>
            <end position="535"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY22510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1641" mass="182184" checksum="5428D4B0BB57C8B0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKJ4</accession>
    <name>A0A1Y2AKJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_550848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CUE"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="74"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="domain" description="CUE" evidence="7">
        <location>
            <begin position="321"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="364" mass="39856" checksum="5E5CC0A4CC60EE39" modified="2017-08-30" version="1">MSGFQNAGVTKGIMMVLAINTLAVSLLHVKPYIHLQVVPHMTKYHQFWRLLVHPFAFANSTELLMGELLLYNVGTNVERSFGPRKYSSFILLSSLLSTFICFVGIVVLHKFGVSAVPAGPYGVIFSLLWQQYRTIPSLYAFRLFGIEFSSKIFSWLFALQLFLSYPPRSVLASLAGLLAGWIYRLDNLVLLPSLSRRRVLRPLKTYRIPLSIHTLLARLFEPLAGSSLPPRRSVRVLPGQMRESSARTTTASTVEPSTLRSLLSSRIGAGAAPPRPPRPSNGTTETGSTVPPPSATGSARAAMGEWVSEMTGRGQGGARAPTEEEIGILSGMFPSSSREAVVRALQRSDHNTAQAVEMLLDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMC1</accession>
    <name>A0A1Y2AMC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_487175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMC1"/>
    <dbReference type="FunCoup" id="A0A1Y2AMC1">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AMC1"/>
    <dbReference type="InParanoid" id="A0A1Y2AMC1"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000069">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="439"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY23440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="710" mass="76157" checksum="1DFA1466BDFBF198" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AME5</accession>
    <name>A0A1Y2AME5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS maltose permease MalP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_473432</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AME5"/>
    <dbReference type="InParanoid" id="A0A1Y2AME5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="30"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY23125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="521" mass="57481" checksum="770D958B91BC22F9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMV7</accession>
    <name>A0A1Y2AMV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_548657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMV7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMV7"/>
    <dbReference type="InParanoid" id="A0A1Y2AMV7"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="362" mass="40574" checksum="DB13538150BBF1A5" modified="2017-08-30" version="1">MTVTQYGSQRGPIDPLGFPPDFPGPKILVTGATGIGGSHIALALARSGYKVHATTRSKKRSEAFSRKWPAAGITWTIVTNQDTPGVYDEAIKGCEGVVHCAGPFDYKHEVSREILDPSVEGILNVFEAAVKEGTVRRVIHISSVAAIHQHPPTDDQDWSSVTYDETCYNLHEFKVATGEKNEDRQYAYTFSKKFAEEKAQEWLKNNPHNFDVVTFCPATQYGPLVQPLDNLSELDTASRRFYDYTTTATQYIPKDPYPTYTAVKDLAQIVVRAYQTPVASGQRYQVVSGYYNYGRLFSILRKAFPTEAHRFPDVPDDGLPLKPHFFTDSTKAERDFGVLHWTPIEEAIVPEFRDLLVVEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMZ9</accession>
    <name>A0A1Y2AMZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_561830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMZ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMZ9"/>
    <dbReference type="InParanoid" id="A0A1Y2AMZ9"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135:SF1">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="85" mass="9914" checksum="D8E2F7F7D85DEAD1" modified="2017-08-30" version="1">MIPRILPVINFVVATTALTFQVYVLLPWHHELSEHFAALKTEQTRQLAEYHEEKRSMLNELHIRIKELEKRLAPPRTVEPSGTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANF5</accession>
    <name>A0A1Y2ANF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_447323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANF5"/>
    <dbReference type="FunCoup" id="A0A1Y2ANF5">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANF5"/>
    <dbReference type="InParanoid" id="A0A1Y2ANF5"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="291" mass="33122" checksum="CF28D1276A83EAD4" modified="2017-08-30" version="1" fragment="single">LPRMIDNGRVELHGTIGTGAYGQVYLAIDRRYSQPAWRAVKCLRRNGLDARQKHFQRREIALHRLASSHPSIVHMDRLIEDGEHLYVVMDYGEEGDLFAMITDKQRYVGDDELIRSVFLQLVDGIAFLHSLGIAHRDVKPENIVCSEHGTRVRICDFGLATSEVESGEFGCGSTFYIAPECLGDWDPEQKSYPTRPGDVWSLGVILVNLVCGRNPWRIASPTDESFNAFLRDPYFLRRILPISEDCLYVLTRIFTLEPSERASLPELRQLITEVRSFTMTEEELLRAHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANR9</accession>
    <name>A0A1Y2ANR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_547539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANR9"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANR9"/>
    <dbReference type="InParanoid" id="A0A1Y2ANR9"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="154" mass="18262" checksum="73343BB0B4083E42" modified="2017-08-30" version="1">MKWSIYHSSSSSSSSSSNVPAGNPTLTRWEAILQDEERYQALQYPTPEDLPGCWSMLDDFMRAYALVPQLRSFYRYGRSSDSLWRWSDFKYCLSLKSETEEKRRELWIKRKAEWWAKRRVEGSSEDVWEIRQTPLENFPPLDPPDVLEDETVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANT0</accession>
    <name>A0A1Y2ANT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serum paraoxonase/arylesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_472569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANT0"/>
    <dbReference type="InParanoid" id="A0A1Y2ANT0"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="41986" checksum="D57AF64CD7A43075" modified="2017-08-30" version="1">MIRGVGEIHLIEDTIDAEDLHLHKESGLLFTACQGVRDSRLRWFPPACRFEHPEWAEKAEGGLRVIDPKTFKATRLELVGFTGAFVTHGIDIISDPADPQCAVFIHAVNHLPNPEYTPSSKLIPKAASQVEIFHHTIGSTSARHIASVAHPLIQTPNDILSTSPYSFYVTNDHHYREGRMRTVEVLGTQAFCAWSTTVHVEVRIVKGKLDSVEATTAVEGLHNNNGLGYGSNRSEVIICDASAGRTHLANIADDYRLKVYNSIDYTSTIDNPTWFEDPYSEATGRDASGIVCAGLVQAWKLAAEIDTGPAASLVWLTTPVPGKKNKWRKKLIFQDDGTLIRSATTALLLAIDPKENDGKKQAWLWITGCLSARMLVVKVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APV1</accession>
    <name>A0A1Y2APV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_546528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APV1"/>
    <dbReference type="STRING" id="71784.A0A1Y2APV1"/>
    <dbReference type="InParanoid" id="A0A1Y2APV1"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF142">
        <property type="entry name" value="FAM86 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55109" checksum="A5161689C78FE26D" modified="2017-08-30" version="1">MLEPSAFPAELIPSSFLPHLPRAQTTLHPLSINDILAHIAVLRTLYLPPIHGGFHESDQGEGHTVKISNNARDMKSARRFSSGLSESMEGLGLTTGDDPASEIDHNRTATAIAEALPDADEECGTGSEASEEENGPSAHLDPFEREWAEKWLNGVVRRSQGWLEEHEDSEGQASDEEMRHKDIEAVLREATAVLAMMAGTSAAGSLTRHLLFPIDPALSPALRTMISLPTNPDLSPETTTFIKSLSMSPVSPTNGFLHRSNASYSPEQAIRSFRRRLSSTVRSDLSTSPESGIRRRRRRKPAVPVLLHDAPMADHLSVGVQTWGSAILLGRQMALRPTDFGLFVDGPKGVRILELGAGTGLLSILCRKILDLHSYGIDEEQDTARGLVVATDFHPDVLANLKICVDLNFPPLVTETIESSTDTSPVSGIHIAKLDWTSFPAFMENGAGEEEMERFVHEPFDLVLASDCVYDPTHAEMLRQVAGWVLRLPDPNIKGDMGGTMVSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQQ6</accession>
    <name>A0A1Y2AQQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_547214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQQ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AQQ6"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="91342" checksum="741287F90DD34A83" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR00</accession>
    <name>A0A1Y2AR00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RRN7-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_545473</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR00"/>
    <dbReference type="FunCoup" id="A0A1Y2AR00">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AR00"/>
    <dbReference type="InParanoid" id="A0A1Y2AR00"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="11">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="12">
        <location>
            <begin position="296"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="78068" checksum="3386FFF3F8404902" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARH2</accession>
    <name>A0A1Y2ARH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_595155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARH2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARH2"/>
    <dbReference type="InParanoid" id="A0A1Y2ARH2"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="123"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="484" mass="52546" checksum="48BD92B2B5024BCC" modified="2017-08-30" version="1">MMQQVSSALGDFTLIDNDDLPLDNSLKKHTDSPYHWKPRYWAPWPLPKDYQLPNAGWTRPPQQPIKLTGVNVIDVEHGRILPDMTVKIRQGFFERVSRRNGNDDKFDIQAQPEWMEIDCKGLYMCPGLIDCHVHILAEAAGEDGWSDIMAAYRVAHDLKGMLGNGFTTIRDVGGATRHHREATEQWLIPGPRLYIGGPVLSQTGGHGDHSDRDAAPTPGMISDGNMGPMSIIVDGVDACLKAARKLMMAGADHIKICSSGGVLSPTDKVDSDQFTVPEIKAICDTVRSMGGTLVTAHCNTTQGARNAIEAGVMGIEHGSLIDEPTLKLMAEKGVHLTPTLIVQEMIVNGPLGAQVPKVSLEKAKVVAGATYEMIKIAHRVGVNIAYGTDIIVDVQLSEFDLRATILPSPVILKQATCNGAKVLGMKDKLGCIKEGAFADFLLLDANPLEDIKILNRPDTHLKAVVKDGRCVRSTVAGLEVEIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARP3</accession>
    <name>A0A1Y2ARP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hepatocellular carcinoma-associated antigen 59-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_545407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARP3"/>
    <dbReference type="FunCoup" id="A0A1Y2ARP3">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARP3"/>
    <dbReference type="InParanoid" id="A0A1Y2ARP3"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY24970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="310" mass="35374" checksum="28203F6C56A16174" modified="2017-08-30" version="1">MFKKRSRPQSVREKPSVESESTSTPEPTTTDSISGPSNPPPVRLEEDDTTQNIEELILLRKLRKSKQGIDLERLNRGEERKSKKSDASEQYGLQSVTGKKGDKDDEFADDVERARRLIKTNNFTKQTNALDVDKHMLAYIESELQKRRGRETAFESSINEAFDPTAELFRIADRFKKEAGIVAAGEEDEEGNVTNSLGMLTSIPEVDLGMDNRLKNIELTEKAKRDMMEQRKAEEARRAQKRPEDEDYAAARFFKPHQRVPSDAYAFDDAKRDAANALPATAPPPRKPRTGHETATDEQVYERFKKRMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ART1</accession>
    <name>A0A1Y2ART1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_600244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ART1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ART1"/>
    <dbReference type="InParanoid" id="A0A1Y2ART1"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="387"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="591" mass="64403" checksum="DFB898C83BDEF78C" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ART4</accession>
    <name>A0A1Y2ART4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_291604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR011333">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="260" mass="29205" checksum="083EFA61800D747F" modified="2017-08-30" version="1">MPNDTVDKDPVMEEGDETTESDKENETSKPEPDKFYTEGDVTLISSDNVSFKIQMFYLQASSAVFRETFAVGELKDDNRDIITFTDEAIESSATIRVFLDTITGKQIPSPQNMTFDWIRFVSLFARKYDCPLLAAIFRMVLAQCVGAAGLAGNLLDPRSIFVTAAILDYPEICQNAISNEANWQWGTSEKELTGDDKDITGVVGESVFSPLSMPLQSVRLIPEDYLWALMRSRATEKGEKRAKEFIRLLDVTKRECDYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASU1</accession>
    <name>A0A1Y2ASU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_485359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASU1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASU1"/>
    <dbReference type="InParanoid" id="A0A1Y2ASU1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF12">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013163955" evidence="5">
        <location>
            <begin position="19"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="57"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="457"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="491" mass="55405" checksum="3A2BDF84CA47CED6" modified="2017-08-30" version="1">MSLRQLLAVAAVLSSALAAPSQQPFSLPNRIDPLKHLSAISPFFLPTEKPTPLPPRCSLTRVSLLVRHSSIMGNDDEYEQTMGPFIHKIGNLSTDDLPDSGEWSFLREWETPIVEERLEELSGRGKKDAKKLGKYIRKQYDDLFPSKKRKSVDEARKGKKDKKGKDTTYKVWTASSDRDIESAKAYILGSFPRHQSGDDGHGDGEVVQLVKVPNKARDWDRSLTPHKACDAFEKQSSLEPASKWLDIYAPKVRARLAGTIPGLAEKLDDQDILAMQMLCGYETIAQGFSPFCHVFTDEEWLDFEYYMDVRFHYMMGYGNDLSPYLGMPWVKTAKHLLGGKDSDSDSTSDDEANSLQPLPEPKLPPNASHSQLLHPSFTHRESPAFVSVFLNLYNSSTSAHPASHPPSLDHRVPNRDWRTSHLVSFLGHVALERFHCKGDGDYVRAVVNGKHEVMHGCEDGLDGSCRWKTFHDWVDERALRWGDWESVCDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASV1</accession>
    <name>A0A1Y2ASV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_590060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASV1"/>
    <dbReference type="FunCoup" id="A0A1Y2ASV1">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASV1"/>
    <dbReference type="InParanoid" id="A0A1Y2ASV1"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY25639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="558" mass="62471" checksum="0EB11A077057F237" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUB7</accession>
    <name>A0A1Y2AUB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_542494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUB7"/>
    <dbReference type="FunCoup" id="A0A1Y2AUB7">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUB7"/>
    <dbReference type="InParanoid" id="A0A1Y2AUB7"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="201" mass="23651" checksum="1AE1BEFBA1A04953" modified="2017-08-30" version="1">MGAYKYLSELYTKKQSDVLLFVSRVRCWEYRQLAVIHRASRPSRPDKARRLGYKAKQGYVIYRIRVRRGNRKKPAPKGATYGKPVRQGINHLKYQRGLKSTAEERVGKRCGNLRVLNSYWINQDGVHKYYEVILVDPSHKAIRRDPRINWIANPVHKHRESRGLTAEGKRNRGLGKGSKHNHQPGRSTWRKHNTLSLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUH0</accession>
    <name>A0A1Y2AUH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_541580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUH0"/>
    <dbReference type="FunCoup" id="A0A1Y2AUH0">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUH0"/>
    <dbReference type="InParanoid" id="A0A1Y2AUH0"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="7">
        <location>
            <begin position="234"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="447"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="544" mass="61831" checksum="CFE06CB92BA87235" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUI6</accession>
    <name>A0A1Y2AUI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_589781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUI6"/>
    <dbReference type="FunCoup" id="A0A1Y2AUI6">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUI6"/>
    <dbReference type="InParanoid" id="A0A1Y2AUI6"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049546">
        <property type="entry name" value="WDR54_beta_prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21031">
        <property type="entry name" value="WDR54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WD repeat-containing protein 54 beta-propeller" evidence="6">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="474" mass="50829" checksum="30034E2C29EE1FC9" modified="2017-08-30" version="1">MAPQEVILSACSSEASGSTAPGRPSSTPALHIHDLLTSAHLHAFKTSTSSPNCVTYVPSSDSRGGSIFASQEGKALVHVWAWQKDQLSLKLHLPEKLTCFVVSPNGCWAAGGSGSGQIYLWEISSGLLVASITAHYRAITTLTFTTDSRILLSSSLDASVHVFLVSRLMDEEDPGSSGKPYGSLADHTLAVRAVSVGRTAGSSGGRCWTASDDGTIKVWSLRPPFNLLTTFTLPTSLVPSTLSVDPLERFFYVGTTSGEVFHVPLFKRRNQVGDLAAIGGGGDGSPPIKTEGSVISLKSPITSLALSLSATHLLVGSHSGEIHVYSLPSHQHLRAISSHGSPITHLSTLPRPPDLVGTSFKPEDWPAMEVKPFERMRVGKPAREVQETTLLLRPSPAAIDRLEALHPPRSWKDYAPPPIVTASDGDNMAEILADNKRLKAQLDRAVRINEKMWTAVVDLKMTESDTNGHMETDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV93</accession>
    <name>A0A1Y2AV93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_540952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV93"/>
    <dbReference type="FunCoup" id="A0A1Y2AV93">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AV93"/>
    <dbReference type="InParanoid" id="A0A1Y2AV93"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="458" mass="50935" checksum="9A60C3C1E3FE516D" modified="2017-08-30" version="1">MPSSSTTTTSKTSAPKPYNRPLPASIGAPSQIGQSSRKGKKAWRKNIDITREEAALELGREEERATGGKVAQKKDTELFTIDTVGDVDVAKKLRRAPKPLRSLAVLSERSAVPSITSRPVPSSSLSSGPSKRLSAAEKARLRRIARRSDEATSSADMKALPITSLRDAWTAEAEPQVIPPGAFGEETIVKRIVKPPRTLAQQREIRAVQIELGRGVEIPEGGVSYNPTAESHGRLLELAVEEEKARLQKEAEEERKIALLAGSVDARKQHVDGEDFAEGMRVGPGYTEGEEEEEGEEEGDSVVKQTKTKRKTQAQRNKALRQRELARLEALEKEQRRLARSVETLSLASIQGTLAKRDRRAKEAERLAKLAKRERERLGLAGGEKIGKHRVKKADVTVQLGEDLAESLRQVKPEGNLFKDRFVALQKRALVEPRERQLPTKRVRKVKEYEKHAYKRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVU0</accession>
    <name>A0A1Y2AVU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_540478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVU0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVU0"/>
    <dbReference type="InParanoid" id="A0A1Y2AVU0"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="550"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="649" mass="70939" checksum="DD0242F95EB0F981" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW58</accession>
    <name>A0A1Y2AW58_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ureidoglycolate hydrolase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_540267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y2AW58">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AW58"/>
    <dbReference type="InParanoid" id="A0A1Y2AW58"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="197" mass="20764" checksum="9202931433A07641" modified="2017-08-30" version="1">MNLQAGPLSPETTHPQLSIISPALTNSATRSGNGGTSTKTPDIAPCTNRYDLAASKRPGRPVLSASRNTPRLVKTDASGVSTLEISMLERHAYTSQSFMPMGGSDKVGYIAVVADSDQSGSRPDLTTLRAFTVRGKDGICYGAGLWHAPMAVVGKVGQRVSKLTPDHGLWNLSVCQRRSGGGLRDGRLGCPNNNIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWJ7</accession>
    <name>A0A1Y2AWJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_540397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWJ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWJ7"/>
    <dbReference type="InParanoid" id="A0A1Y2AWJ7"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="436" mass="48072" checksum="4B9106B3B80F0E96" modified="2017-08-30" version="1">MSYIPANHPSQPEPTIAPYPPASSLPPDNYDTSLNLPSAGNSRSTKTIKTESKTDTREETSTREETDLDLPPVILGGGQFGYGIYDDDQGVLSDMPVRVIRMALRSGMNAFDTSPHYHPSEIIIGNALKCLESEFPRSSYKIITKAGKYGPTPRDHVYTPETIMDSVQRSLKRLHTDYLDVVYLHDVEFIATDPYPSPAGHHLPALDPSTSEAKTFHLDTTTYSPLGRGDEIILGALGALRTLQSAGKIRKVGIAGYPLPLLLRLSLMILHTTGIPLDIVQSYAHQTVQNAALGEGYLEAFTEKAKVNQVVNAAPLSMGILTTRGGPDWHPVIASKSPLEAVCKQAVELCQQRETSIEVVGTDFGFRVLRQQDLKRVPVVIGCKNLQEMERTLKSWWAVNNSDGHVKEIGEVEKQVMALFDQRGVRNWSWQSPMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWY7</accession>
    <name>A0A1Y2AWY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_241556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWY7"/>
    <dbReference type="InParanoid" id="A0A1Y2AWY7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="265" mass="28993" checksum="6DD8990F214326CA" modified="2017-08-30" version="1">MTTHGLSSSTPTHNNRDSDASWIHDYRTYMKHFDDESPQCSGESSLDSRMLVDPLPRQQQEEEEHQQQQQQQPQPQPQHRLSRSSSLRDSLLRPATRRSMSPLSESTLVGTEGSRNASSPSSMGTTLLGRSATGSDDDSSSINESVCGTSLHRGRSPIHSSPSNIVVRSPRSVTPTGSPRRDRLHAPLIPSSLSSSARTSSCPPGSTRNRRGNYAESSKFNGDGDSSNEYPRGIQRLPSTITVLTDDRKFAITAALKPQLDPQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWZ1</accession>
    <name>A0A1Y2AWZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_539074</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWZ1"/>
    <dbReference type="FunCoup" id="A0A1Y2AWZ1">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWZ1"/>
    <dbReference type="InParanoid" id="A0A1Y2AWZ1"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="65"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="183"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY27062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="748" mass="83103" checksum="A27FC470F94CF683" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXF5</accession>
    <name>A0A1Y2AXF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_540046</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2AXF5">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXF5"/>
    <dbReference type="InParanoid" id="A0A1Y2AXF5"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="309"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY26907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1300" mass="144348" checksum="F8310C29DCA5650B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXK5</accession>
    <name>A0A1Y2AXK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_538349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2AXK5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012801967" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13695" checksum="16CE8E07DA1B8C26" modified="2017-08-30" version="1">MKFSSTVVLFATLFGMVTTVKGQLIPPSAQFYTDTGCTVANGGLHPIISNECFSQAGSGSVKVPDTGLGHDIFHFNLFALYTSDPSGDEPCSTLNEPPITFYADGSCIVLNNTDNESYQFAGPCGLGLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY25</accession>
    <name>A0A1Y2AY25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_538447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY25"/>
    <dbReference type="InParanoid" id="A0A1Y2AY25"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="341" mass="37672" checksum="DCA81F9E821098B9" modified="2017-08-30" version="1">MTDSILYPHEPSTLLALLESHLPYSLPVYGTLKRLPLSSKDSQAEPAWASFPSSSIPNLFTSTSTSTTSTTSTSITPTSTLEPTSTSTSSSAEPWIIITHLPSPLRNQIRLYSSSEHPSSSSHAQIEKARQQVLTCMLEFVKMSPEADRAGAVNLLWSGHLRDLFGTKDLGVCDTWIKVDVNDQSQGTQETKGTQETQGTQGTQGGIQGESDADMDGLVVDDAREEDCEMIMNTRDIPIPLPYYHSLVRETTVIRTISTGTAISWSMTQHDGVIGSLYTLPDYRRRGLAQIVVEQRIKRDLETGFGVGGYCYIYRGNKGSEGLFGRMGWQRRWGVQWVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYD7</accession>
    <name>A0A1Y2AYD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_540000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYD7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYD7"/>
    <dbReference type="InParanoid" id="A0A1Y2AYD7"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="8">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="666"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="918" mass="104289" checksum="D2D56A5925195BA3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYR3</accession>
    <name>A0A1Y2AYR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_538563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYR3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYR3"/>
    <dbReference type="InParanoid" id="A0A1Y2AYR3"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="112"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="374" mass="39773" checksum="C33DC82496F28124" modified="2017-08-30" version="1">MSSPGYTINGDSTIVSPPNGKAPMHAANSDELDRYVTDEMPRTDKMNPRGGARDAAGALLVVQPLKKNEMQQSYSQDFGTGSIEHGFYGSMMNGLGSCVGAIGMIPCCPFPNPFKSVDQGSVGLISRFGQFYKSVDPGLVKVNVCSEQIRVVDVKIQLTQVPRQTVQTKDNVSVEVDSVICWHVISPYRAAFGINDVARALVERAQTTLRQVVGGRVLQSVISDREGLAHEVAEIIEATAEKWGVAIESILLKDINFSVELQQSLSSAATQKRIGESKVIAARAEVDAAKLMRQAADILASPAAMQIRQLEALQNMARTAGSKVVFVPMNLGTMGAAGMDNVAQQISASAREEGYGDGPGPATNAGLISSMASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYV6</accession>
    <name>A0A1Y2AYV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_538204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYV6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYV6"/>
    <dbReference type="InParanoid" id="A0A1Y2AYV6"/>
    <dbReference type="OrthoDB" id="2564497at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="95" mass="11226" checksum="2B6B20291E73869A" modified="2017-08-30" version="1">MYSEGFNQPCALEKTLMAADEHLGRSDLADFIRRGKKFQRLLDILTFQVYKVEHLNATRRAFLDLPDDGQIEPSTQDEWIRLAMKKYKDDEGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ05</accession>
    <name>A0A1Y2AZ05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_506164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ05"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ05"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ05"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="519" mass="58805" checksum="32DCD0A5CD32BFCA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ37</accession>
    <name>A0A1Y2AZ37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_565720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ37"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ37"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ37"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="233" mass="25777" checksum="8375AB08D7D25F30" modified="2017-08-30" version="1">MAPKGSFPREQKLVVVGSGGVGKTALTIRFVTSQFYDQGYNPTIEDSYRKQCVVDDEAVTLEILDTAGQEEYAAMADQWYNFGAGFMLVYSITDHPTFEAISGFHQDILRVKDKNYVPCVVVSNKCDLGNLRAVGQLEGRQLAKSLTAPFIECSAADGVNIDIAFKELVKLVRKDERVSTLWFVSFYEQPPRFLVCVCVLTGFQTVEIEENDGGSIGSDAKTRSCTFKSFTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ88</accession>
    <name>A0A1Y2AZ88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BCR39DRAFT_537154</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ88"/>
    <dbReference type="FunCoup" id="A0A1Y2AZ88">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ88"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ88"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="126"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORY27784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="665" mass="73421" checksum="9B3AA95D8CD488EB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B002</accession>
    <name>A0A1Y2B002_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_588842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B002"/>
    <dbReference type="InParanoid" id="A0A1Y2B002"/>
    <dbReference type="OrthoDB" id="5346979at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30798" checksum="3D2B9E25AD84CF9D" modified="2017-08-30" version="1">MSFLSSFLTPSTSNSDEAPRERKKLPRVVFIVSGAAMAMTIGLTVMMVPYLRQAIRHAKTVPDSLSNRHLDLRSTRLKELSLASSRNQPATSSSPIVPHTLETPLPSSSFTSSASTLDNELHGETTMSPEMENIRSFNNNEERHLYGSVTSSLDPQPLGEASTRTSKAIEEDSKAVSALMGIQALGIATALVFGSTGLGVFIVAKLLGVDDMTEFRIRMRETLQSSMPGLVSSIHEDHSVDRHLRPGNKVTEEDQVAMDELNDWFRSLDEHGNEQTETKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Y4</accession>
    <name>A0A1Y2B0Y4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_534854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Y4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0Y4"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Y4"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="147"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="552" mass="59805" checksum="C46F43584C776472" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B165</accession>
    <name>A0A1Y2B165_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L18-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_534839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B165"/>
    <dbReference type="FunCoup" id="A0A1Y2B165">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B165"/>
    <dbReference type="InParanoid" id="A0A1Y2B165"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="190" mass="21542" checksum="D762B7F5EAE5C5D4" modified="2017-08-30" version="1">MGIDLRYHHVKKGNRQAPKSEDPYLLLLVKLYRFLARRTDSRFNKVILRRLFMSKINRPPISLSRIIKETRNSNPDNAKTVAIVGAVLDDERLPEVPKLSVTALRFSASARERITAAGGECLTFDQLALRAPTGSNVILLRGKRNVREAVKHFGGPLKGGKPYIKSKGRKFERARGRRKSRGFKIKSTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2Q0</accession>
    <name>A0A1Y2B2Q0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDP-fucose protein O-fucosyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_565191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2Q0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2Q0"/>
    <dbReference type="InParanoid" id="A0A1Y2B2Q0"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53640" checksum="5BF125478CF3510E" modified="2017-08-30" version="1">MRITLPNPLGPPIAVDTAHLDNLRSKLPRGIPSPGAIFRRPHFRLGIVLLLIIGMLTLHPTPPFPPSYSLEARMERNLPQLYDDVRYGEGKAGRFIKFDVPQGTGFTECPISDHRLQHHLAVLGNRSLAYEPFVQDRVWLPFRLTSFPWHSSQIPLSAFIATVISGFEAYFNAPRAVPASYYSAVCRRNQRVYSILGDDGLNLVADGQARIHQLQVLLAGSDVGCIRIEGEVFDDPFFDSQAPLELYESFIRSPVMKHFSFSPTVLAIINRAMPKLSRNSELYDLDRVAHAEAEPYRTSMWRHILALHLRRGPEWEAVCEEKGMRSAPFVSFNKLPLLPGNENVPPSSDMVEAARMGLYRAKCLPQTLEIIARARRMRKNHPLLRSIYILTDADNSWAEEIRMWLQSEGWDNVFVGQRDIYPDWQDREVGVAVDMEIARRAGVFVGNGFSTTSSNIVLLRSRDGVHPDLTQFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2U7</accession>
    <name>A0A1Y2B2U7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_534009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2U7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2U7"/>
    <dbReference type="InParanoid" id="A0A1Y2B2U7"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="82"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="477" mass="55175" checksum="3A10F693D377CB12" modified="2017-08-30" version="1">MSSTTNGHKSDYLVVKGENILLHGEPILLKGAGLGGWMNMENFITGYPGHEHQARAAIKKAVGEEKYEYFFDKFLEYFFGEDDAKFFASLGLNCIRLPVNYRHFEDDMNPRVFKKQGLKHLDRVIEICAKYGIYTVIDLHAAPGGQNIDWHADAGGHQALFWDHKDFQDRTILIWEHLARHYKNNTWVAGYNPLNEPTDIQHVRLLAFYERVEKAIRAIDPHHILFLDGNTFGADFSRFGEPLPNSVYACHDYSKFGFPNPPAEFTGTPEQIEIHEKSFARKVEYMQHHHSPIWNGEFGPVYQSASDGLPDWEAINERRYAVLECQLDIYAKARASWSIWLYKDIGYQGMVYAGEDTAYMTLLKPFLQKKKATAADEWGCDDTPVRHVFDPLEKWFLESVPSLSRRYPQTWKPATHIGRLVRNILLSEELCHEFGQYFEGLSFEQLDELAKSFSFENCKQRTRLNQILTADSQRTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2W3</accession>
    <name>A0A1Y2B2W3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_559399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2W3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2W3"/>
    <dbReference type="InParanoid" id="A0A1Y2B2W3"/>
    <dbReference type="OrthoDB" id="2587207at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="168"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="581" mass="63454" checksum="4423C47F6BBABC8D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3L5</accession>
    <name>A0A1Y2B3L5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_532333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3L5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3L5"/>
    <dbReference type="InParanoid" id="A0A1Y2B3L5"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="580" mass="63750" checksum="89A7440DCE91079B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3U6</accession>
    <name>A0A1Y2B3U6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Inositol phosphorylsphingolipid-phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_495338</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3U6"/>
    <dbReference type="FunCoup" id="A0A1Y2B3U6">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3U6"/>
    <dbReference type="InParanoid" id="A0A1Y2B3U6"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="350"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY29503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="520" mass="57107" checksum="4417C31A5D7A7033" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4I8</accession>
    <name>A0A1Y2B4I8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_505425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2B4I8"/>
    <dbReference type="OrthoDB" id="2596678at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="278" mass="29777" checksum="7C00C88862022A8B" modified="2017-08-30" version="1">MPTHHSRSSGPTSPNPGADDINNLNLDAVRARLERNSRVLGSGIFSPSPTTADDPVRQKLLEAREQLLAREQELLALGVEGMNIEPGSIPESSSAARRRSSTGVGGSGELGGARSGKASALEAIQANESRLAKNGLLIPLSETVALGQRDYYDAAAQRLSELSLAQSSPTPAKSKRHPERPDQTDEIARAQATARMRAFMSYKDEEDDGEGEDNGLIDADWEGEYDGDGDRLEFAGEAGGGGGGGEWREKGTGEEVDELGEDDERWPEGSEEYLDRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4P5</accession>
    <name>A0A1Y2B4P5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_588180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4P5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4P5"/>
    <dbReference type="InParanoid" id="A0A1Y2B4P5"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="147"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="780" mass="85793" checksum="AB7865F7806D49DF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4S8</accession>
    <name>A0A1Y2B4S8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_467114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4S8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4S8"/>
    <dbReference type="InParanoid" id="A0A1Y2B4S8"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000504">
        <property type="entry name" value="C2H2 transcription factor swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF144">
        <property type="entry name" value="METALLOTHIONEIN EXPRESSION ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="142" mass="15831" checksum="887BCEDCF2A67F13" modified="2017-08-30" version="1">MDPPRTTESAEVPGKAGLPKKFIERLYTCITAVETGPGGQQQQVKRFKCLIEGCDRSFPRKSAVGSHIQTHLDDKPHVCDHEDCGAAFVRQHDLRRHQRIHRGDKPFNCECGKGFARGDALMRHRQRGICSGGIAPGQRTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4X0</accession>
    <name>A0A1Y2B4X0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_161521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4X0"/>
    <dbReference type="InParanoid" id="A0A1Y2B4X0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="99" mass="10919" checksum="BF139662BD724855" modified="2017-08-30" version="1">MITYTTSFLGPSGILCDISPHSKTTINLIGPTVSPSTLDRRWPPLSLSKNVYLVPQSDQNGCPKTPFSLVDSKHVPNHLRGRSFASTTPIQKRDTTSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B551</accession>
    <name>A0A1Y2B551_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y2B551">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B551"/>
    <dbReference type="InParanoid" id="A0A1Y2B551"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:protein tyrosine phosphatase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="138" mass="15582" checksum="AC77D281FF3E5A61" modified="2017-08-30" version="1">MSFGPSYKYINADELATLIKSSSSSQLRDIAVVDVRDDDFAGGNIIQAINAPSRSFHEDVKGLVERLNDVPKVVFHCALSQQRGPKAARIYAETRSVLKPDSAKPQEIFVLRDGFTGFQQKFRNDPELVEKFNKYYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5U6</accession>
    <name>A0A1Y2B5U6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_529976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5U6"/>
    <dbReference type="InParanoid" id="A0A1Y2B5U6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="56" mass="5940" checksum="DD87ABC3650B4DF4" modified="2017-08-30" version="1" fragment="single">MSETERLGMPLMVAAELIVIVIVLIVIVIVSEETVAVIVLLKLLGAVALRDPCGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5Y4</accession>
    <name>A0A1Y2B5Y4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5Y4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5Y4"/>
    <dbReference type="InParanoid" id="A0A1Y2B5Y4"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="70887" checksum="7E2E2C44030B38CB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6M6</accession>
    <name>A0A1Y2B6M6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_529885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6M6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6M6"/>
    <dbReference type="InParanoid" id="A0A1Y2B6M6"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="284" mass="31500" checksum="C4ECD656073273B1" modified="2017-08-30" version="1">MSQPPNGKSNGHSVEGEPEEERSFDYGPGRVKFADKEKERQYVKERLALAYRVLSHLGVVEGASGHLTSRDPIDRNCFWVNPYGLHFSRMKASDLLLINHSGDIIMGGKPDRQRYNTAAFVIHKAIHDARPDVDSAVHCHSPWGKAFASQGRELPIYTQDAAIFYNDHALYNDFGGVVLSDKESAQIVGALGGKKALIMQNHGLLAVGRCIESAVAWFFLLENECRCVMRTEASCAFTGKPPISLRPEVAEFTWRATGTEEGGKHEAEPFFDLVEELCQGAHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B822</accession>
    <name>A0A1Y2B822_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_99317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY30981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B822"/>
    <dbReference type="InParanoid" id="A0A1Y2B822"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="229" mass="26206" checksum="982373ECF50D1992" modified="2017-08-30" version="1">MSSPPPLAAKENLSLETSSDENLSPASSQLTRSLTPRPPDKQPATRNISAPDGSHRARSNDLPTPQRDPKSGSKRKHRDDDAAIEVDSPRTIERVLRWRTELPGDWALSKGGDGGIMGDVEPFGPEFFASMTREEAYRWLKLKQLISAEESDDRYHEKHLKRLESAFEQQVSSNESTKRYREKKLRLMRMDLAVRYAEAKCRQDPNLNFMLTLEEGEKRYEVNKKVHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B848</accession>
    <name>A0A1Y2B848_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">DNA topoisomerase</fullName>
            <ecNumber evidence="4 13">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BCR39DRAFT_558370</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="4 13"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B848"/>
    <dbReference type="FunCoup" id="A0A1Y2B848">
        <property type="interactions" value="732"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B848"/>
    <dbReference type="InParanoid" id="A0A1Y2B848"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 13 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="18">
        <location>
            <begin position="169"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="17">
        <location>
            <begin position="746"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="17">
        <location>
            <begin position="829"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="896"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="947"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="985"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="635"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="781"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="910"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1005"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORY31011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112035" checksum="61012177AB995B50" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B867</accession>
    <name>A0A1Y2B867_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_564743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B867"/>
    <dbReference type="FunCoup" id="A0A1Y2B867">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B867"/>
    <dbReference type="InParanoid" id="A0A1Y2B867"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012779213" evidence="7">
        <location>
            <begin position="16"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="191"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="522" mass="54384" checksum="F30054ACBA4BE96F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8D1</accession>
    <name>A0A1Y2B8D1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_527782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8D1"/>
    <dbReference type="FunCoup" id="A0A1Y2B8D1">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8D1"/>
    <dbReference type="InParanoid" id="A0A1Y2B8D1"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="86" mass="9559" checksum="742380EC313ECEB2" modified="2017-08-30" version="1">MATSDKLLGGLMLLTAIFVFVYYTTWALLLPFLPDSSPLQPLFPPREYVIRIPLFILVSGLVGIGLFFGRIMLSEARRRSGAGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B941</accession>
    <name>A0A1Y2B941_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative C-3 sterol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_527562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY30997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B941"/>
    <dbReference type="FunCoup" id="A0A1Y2B941">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B941"/>
    <dbReference type="InParanoid" id="A0A1Y2B941"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000944">
        <property type="entry name" value="Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="308"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="431" mass="47904" checksum="14637A743B22E736" modified="2017-08-30" version="1">MPSSESYLVVGGCGFLGRHIVEQLLARGETQVSVFDIVQRHFDSNVNFYIGDISKPEDVENALTKSGATAVIHTASPAHNLGRQLYELVNVTGTRTLLDACLPSPTVKKFVYTSSGGVIFNGDQDVVCADERLRYPERALDAYNETKVAAEKMVIAANGEQLLTCAIRPAGIFGEGDRQMINAFYEVVKNNQTKFQIGYNDNLADFTYVGNVAHAHLLAVDKLGTTYPYSSFRDPLDSIELSTGALRVPTSDAHPLGPNTSPSEASLFAARRYESGQHDPADLRPVLRNRMDQFNNEASLEDESSDAGYPIAGQVFFITNGEPIYFWDFTRSVWKGLGHIPPYRIILPAFLGLILATLAEAFSKFRGKEPGFTRFRVSQAINNRYYDIERARRLLGYEPIVGLVEGMERWTSWYRGELAKQSQTVESDKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9U2</accession>
    <name>A0A1Y2B9U2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_504886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9U2"/>
    <dbReference type="InParanoid" id="A0A1Y2B9U2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="44151" checksum="545531F97E07288C" modified="2017-08-30" version="1">MSDTDTGKGPTAYSRDVLNILVRWKIDNAQTRERWRRAATIYEKSLSDTVPDESLQPSSPESIRTLTLGKDESTLNFDHDPSSCRRGSSNREKIPWRQGSMDSDISGTTLVSPMHDDPCSGVQKWILLHMLNGGLHQYGGFSRQGSSDSEPIATTLQDWRVISRPPQSQLLSGSQSQAPLEISDSNASKDTMIGGVYHEAPAEGSSVKSCQAQGGSSRELHPLPPGGQLPKAAQSDKETEPQSFDMCPSTSPSFSIDHLPSSLVTNRSFSSLAAKPITKSPSRTANLRSSVLNAGSVTCFTQSNSTAGTNPRNVSKITKVRQSRTVYTNLRERLKNQDLLDCGDPDLTLEPIQNAYGTILNFMLHTSTYQRNKFHKTARKKEDTIRWLLNRIIEERPEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAN1</accession>
    <name>A0A1Y2BAN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_81317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAN1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAN1"/>
    <dbReference type="InParanoid" id="A0A1Y2BAN1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="312" mass="34454" checksum="779D8BAA556DFFCC" modified="2017-08-30" version="1">MSYKSTILITGGSSGLGYETSLQLAKSHPDLLIVAASRSSPAEELLSLANVKWFHLDLSTKAATRSFVTAFLAESFPPISALILNAGLQRFPKVYYTPDGLEEMVETNHLNQALLFFLLQERLEPTARIVVVSSSVHDPEIKRGFPEYTTAEAAAHPQGESYKSFQGGIDQYAVSKLCQLLFAYALHDHIVAAGKSWIVLALDPGVMPTGLFRWTPGIVRILFNWFLRSGIPRLLIASDYYPVAETARSLVKLAMDPEFAAKEKSGKYYVVMGPAESPSSKLSHDKAIQKDLWDWTVKELGVQDEVKALGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAS5</accession>
    <name>A0A1Y2BAS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_68265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAS5"/>
    <dbReference type="InParanoid" id="A0A1Y2BAS5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="154" mass="15987" checksum="50EF4332DE7512DC" modified="2017-08-30" version="1">MGSFGRGPPAVPAHGPLYGKHLIGTAWPPVPPGAGGPQLRPPPRSNLSHSSQPLESIVDEDRSTTSSSFTTKTTTMPKSIPSPNGTGFGFAQREQVDQVTVNSLGTRQSLSSVESSTMTIKPDDAAGGPNKPKLKGQIASLAKMLSGLKTKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB06</accession>
    <name>A0A1Y2BB06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB06"/>
    <dbReference type="FunCoup" id="A0A1Y2BB06">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB06"/>
    <dbReference type="InParanoid" id="A0A1Y2BB06"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="237" mass="26171" checksum="5C884DFC2E455F4D" modified="2017-08-30" version="1">MTAIRNDQNIVQGHLDPPLSPLGKTQAMKLAEHLQLVPFSEAWTSDLARAEETAKVLLTFHPRVSLNIDPRLRSRGMGSLQGKKWQDGVEYPADVESDQILSTRLKEWLDNLITYHTPVTSPAGTPRTPISPADPGSGTVLAVTHEECLLSLLRLLTSSNKDNHNHALQLHVPQTVDTSLRLGNTAMTIVRVWWEDVGGLSPFGDGQLGMGKMEPRGRLEAWGVEDHLIDDTEQPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCI5</accession>
    <name>A0A1Y2BCI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial inner-membrane-bound regulator-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_523571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCI5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCI5"/>
    <dbReference type="InParanoid" id="A0A1Y2BCI5"/>
    <dbReference type="OrthoDB" id="3362817at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="87491" checksum="246FE1461E739317" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD22</accession>
    <name>A0A1Y2BD22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_379483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD22"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD22"/>
    <dbReference type="InParanoid" id="A0A1Y2BD22"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001781">
        <property type="entry name" value="zinc finger protein 496 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="436" mass="47297" checksum="AB14A83A816EA8FA" modified="2017-08-30" version="1">MDYRSYSNESQRPQQPSLSRTPSMSMNNAPAQGSPLASPYQRQVSNGYPSPHAQSPQRPNVYPQQYYSSGSYPSSADMPRSMSYPSTYAPPYSYLPSMSAAPMHQGGGLPPLARHNTTGAMEGGIPGMDRPSLGYSFANRLPLVDRPFKCDECVQSFNRNHDLKRHKRIHLSVKPFGCDKCGKTFSRKDALRRHWLVKGCRGEDGATAPILPMFPLNSNPPALSPPSPPGNVSPSDHAHSGPSYHPSSFSHPAAPPPLNTLPMRQASDQSQIIVTPNDVANQSMRAEIAGPMDEPMVVDSTMSGPHAGSGRGSGSSMADSNGYFEGVVGLKHDGTALIDNQAGTPNSPYSKYSTSPHPYRRPNGVASPHRSQPSPSYGSRTPNGPDQLGKPIFAMPFTPSGQHYHSQDGMLAPPHESIRMEKQHSTESAPESWQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDA8</accession>
    <name>A0A1Y2BDA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_521708</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDA8"/>
    <dbReference type="FunCoup" id="A0A1Y2BDA8">
        <property type="interactions" value="899"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDA8"/>
    <dbReference type="InParanoid" id="A0A1Y2BDA8"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1066"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY32811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1151" mass="128977" checksum="3AB42EB606E704B7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDD5</accession>
    <name>A0A1Y2BDD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_522792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDD5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDD5"/>
    <dbReference type="InParanoid" id="A0A1Y2BDD5"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="278" mass="31832" checksum="E9B742C8EDCE08B0" modified="2017-08-30" version="1">MSTTIESDRSLSEPRPPKGTIAVDMDDVLCQTNLTIVSMHNEMFHTDPPLTLDDFQNYLYWQNRGWGTAEETVEMVSKLYAQGLYWKSPPVPGAKEGLLKLKAMGYDLIIITARSERQREGTEDWIAQYMPDIFDEIHFTGAFQHLEPTSEEKEGHVAKRAVVSHHKRSKAEIVHSTQSLFLIDDSAENALDASRATPPCRVILFGQYPWNAVVHRPELSTPDDSLTYVDKEKKGLLDGAKKKRQDQIKEGWLPQGVERVKDWKEVIHWVEQLESRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDZ3</accession>
    <name>A0A1Y2BDZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDZ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDZ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BDZ3"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="63"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="633" mass="70191" checksum="AB99C943CB1911A4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDZ6</accession>
    <name>A0A1Y2BDZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferritin-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_564025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDZ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BDZ6"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="277" mass="29140" checksum="524B6C065D7F11D0" modified="2017-08-30" version="1">MSGSGPNDTQVLQYALTLENLENKFYMDALSQFSADDFTAAGYPDWVRGRYTQIAGHESDHVSLLSGALGNDSVAPCNYSFPYTDVKSFISLATLIENVGVSAYSGAAQYITTPAYVTIAAVILTTEARHQSWQSSSVAMMAPWSSAYDTPLSLDMVYTIASAFITSCPSTNAALPVMAFPTLTVANASANAYVDFSFDDNSTDTKYAIFYNGLGNTAVQLDESNGATIPGNLQGVSYVVVSTASSAADVSNSNIVAGPAILDFPFPGSASNPAFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEC8</accession>
    <name>A0A1Y2BEC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_564159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEC8"/>
    <dbReference type="FunCoup" id="A0A1Y2BEC8">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEC8"/>
    <dbReference type="InParanoid" id="A0A1Y2BEC8"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="316" mass="34707" checksum="A1F2FA36060ED721" modified="2017-08-30" version="1">MSATYTPVAGFSRFNLAQIQLRPGEEDKTKNLDHARDLIVQAAAGGGDDSRKADLIILPEYFNSPIANSAHKKHAEEVPDVPAGGKIEKKDLPAASPTLKMLSDAAIQTGIYIIGGSIPERDLTDDTKVYNTMTVWDPQGRMIGKYRKMHLYDVDIPGGITMRESDVISPGSEPTVMKFPFGTVAVAICFDIRFQFLIASLREANPDICAYLLPAAFNLTTGPKAWEILQRARAIDNQIYVGMCSPARKQGEEYVAYGHTLLCDCEGKIISTPTPEDEGETIVYSTLDPEHLSAIRKGVPTLTAQRRDVYNLPSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BER4</accession>
    <name>A0A1Y2BER4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_522888</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BER4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BER4"/>
    <dbReference type="InParanoid" id="A0A1Y2BER4"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000682">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="13">
        <location>
            <begin position="420"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY32565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="823" mass="89763" checksum="FC408220F5E1706E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF71</accession>
    <name>A0A1Y2BF71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_521350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF71"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF71"/>
    <dbReference type="InParanoid" id="A0A1Y2BF71"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="444" mass="47316" checksum="634BD4CB5AB15951" modified="2017-08-30" version="1">MSTVADDERPLLGGASTGGNAHEGYGATSSSTSSESEVSEVEEKQHKEFKEIWALCLGLWTAVFCSALSASIVANIQLEIGSSFRAGSLVSWLGTAYLLGLTAMTPLYGRLAQVMGRKGAMLLALGLFFTGTLGCALAPSMIFILFARAIAGAGSGGLLTVTAIIISDLVSLADRGLYQGGVNVLFGAGASTGAVVGGAVADRYGWRVAFWIQIVPILVATVLVITQVHVPHHKGELSAWEKIKRIDWAGSVVLMISMSTFSISVSLATSSGYPWTHPLVLTLLAITISVLPLFAYIEKTAVEPILPLDLLTRAQPSLVLMGFVLNTATTFARLFMQPVYLHVTRGLNGSETGLLLLPSSISGALSSLYAGWHMRHFKEYKWFQFVVSLIPWLQALSITTLWGPETSVHRLWIEMAIGTLGGGATITTLLSTSFVSESMPLTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFU7</accession>
    <name>A0A1Y2BFU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="6">EF-Ts</shortName>
            <shortName evidence="6">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSF1</name>
        <name evidence="9" type="ORF">BCR39DRAFT_518578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFU7"/>
    <dbReference type="FunCoup" id="A0A1Y2BFU7">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFU7"/>
    <dbReference type="InParanoid" id="A0A1Y2BFU7"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="8">
        <location>
            <begin position="108"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="375" mass="40038" checksum="78C6063E262D26BF" modified="2017-08-30" version="1">MFVLQPIRTCSATCTRQAWRSLHCSRPLFDAPTTKVPVSLIAELRKTRPVPMSVAREALSKSDNDLARALEYLESNSASAEKKASKVAGRDTTEGTIAVSLLSGKRVAMAHLACETDFVARNDVFLKAAKGIAGTAAFLDVPSEEEKRNIKLGEDPIQTWPTSALLSAPLIALPDDGSEPTPVQSDPTTIQQTLLSALHATGENLRLLRTVSFAAPFPSSPEVRYVPGVYSHGGSTPNTGRVGSIAVLAVTSADTSTPIASMIHGSNGSDLETALLKLARDIARQIVGFPTKAIDRKSKEGKDAEEGEVLIEQEFMMIGDERKVGDVLKARGEERGVHVRIVGMRRWSAADTIAEDSSSSSVEGTETTQDTVDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGF0</accession>
    <name>A0A1Y2BGF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_521495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGF0"/>
    <dbReference type="InParanoid" id="A0A1Y2BGF0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="986" mass="108092" checksum="82D41B38C5A8371D" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH65</accession>
    <name>A0A1Y2BH65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_520109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH65"/>
    <dbReference type="FunCoup" id="A0A1Y2BH65">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BH65"/>
    <dbReference type="InParanoid" id="A0A1Y2BH65"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="9">
        <location>
            <begin position="337"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="8">
        <location>
            <begin position="706"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="588"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="38"/>
            <end position="51"/>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="120"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="138"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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            <begin position="197"/>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="906" mass="101393" checksum="EA124625165700CC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHE4</accession>
    <name>A0A1Y2BHE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BCR39DRAFT_516787</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHE4"/>
    <dbReference type="FunCoup" id="A0A1Y2BHE4">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHE4"/>
    <dbReference type="InParanoid" id="A0A1Y2BHE4"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORY34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="525" mass="57448" checksum="C26651A23EF5576C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIK2</accession>
    <name>A0A1Y2BIK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_513586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2BIK2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012847397" evidence="2">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="223" mass="24760" checksum="9D267040A973C4E0" modified="2017-08-30" version="1">MPLFLASLVFAVSLSLLPSIEPEPTTPNPDPKSEHTLQHQHQHQHHLRNLEHPSPTFPSPSKRPENGPGPGPGPGRGEAGNGNGKKPSQIARKRKRNLSTELKARQINWRPIELDFLLHSDRRVDEGFQALGFFDIETRPSSSSSSSSSSMSTSTSTSTIISRRDSEDSKFEQVGNEVDDIDYDPIILGPRLRRCSSLPDFTSMSPENYEYTLESSSLDDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIP9</accession>
    <name>A0A1Y2BIP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_513871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIP9"/>
    <dbReference type="FunCoup" id="A0A1Y2BIP9">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIP9"/>
    <dbReference type="InParanoid" id="A0A1Y2BIP9"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="754"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="829"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1125" mass="122613" checksum="DBDD3FA7C8C3F326" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIX7</accession>
    <name>A0A1Y2BIX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adipose-regulatory protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_518237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIX7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIX7"/>
    <dbReference type="InParanoid" id="A0A1Y2BIX7"/>
    <dbReference type="OrthoDB" id="2593582at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
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            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
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            <begin position="475"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54340" checksum="25F1E76F3B7521D2" modified="2017-08-30" version="1">MARPSTASASLDPYLRERAANPSLIPSKSTRTARIATTNATKNEDFLDFLRGLGRLVLSPVTFPAHLIHQTLTSPLTISLVLKLLLLGALTLASAVFSVLAVGAFWYSWGTGGLIEVEGWLVYGAKSHRSPHTLIPLPVERFQEDLRYDVQIEMELVRPSRGSEEMGNFMLTLDLRSNRDPEISVLRASQPSLPPPPLPSTLLSLPSIPTSLIPPCVIPWPFRSLCPSRLLGYDGRPNSKIRERRKRGGFASPAHGKDVVLLRKELMEAVLLNPGRGGDAQIGSAFVSIGREDSFGENDGAQCDVKTREVRTTGWVVVRFVPRPTGIRWLLVSHPFPPLLLLPPISLGLTLSSSFFAFIIISYLRSASKKKSKRTAQPILEEKVLEDKRKAVFAERDREERREADRRKAEWEEVESSALGGMRRVPEERKRSRIGESTIGGSETTVPTNIQSFATIPESGDETESTATGTATETRPGDHSRRHSRDMDGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ75</accession>
    <name>A0A1Y2BJ75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ75"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ75"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="150" mass="16521" checksum="5F933C97C51C3236" modified="2017-08-30" version="1">MSEAPSQAEWARRHTNAQNLPTAEEIRTFVPTESEWGYAQSYVGKDTSYASKWFAMRAIRDNVTLTRATIQALTKELDPNVKFPYESQFTNSPSTPNLPSFHTRGSDAGLPPGHDGRRPSDASFASSSSKRSSATARHLRSIFKKPSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJY1</accession>
    <name>A0A1Y2BJY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_147419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJY1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJY1"/>
    <dbReference type="InParanoid" id="A0A1Y2BJY1"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="791" mass="87522" checksum="26AC4F8DB74DC137" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKT3</accession>
    <name>A0A1Y2BKT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_555534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKT3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKT3"/>
    <dbReference type="InParanoid" id="A0A1Y2BKT3"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="106"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="692" mass="76565" checksum="0E022F7ACAF6D545" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKT7</accession>
    <name>A0A1Y2BKT7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV-endonuclease UvdE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_556217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKT7"/>
    <dbReference type="FunCoup" id="A0A1Y2BKT7">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKT7"/>
    <dbReference type="InParanoid" id="A0A1Y2BKT7"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="639" mass="71620" checksum="0EC66F7D601F56D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLR6</accession>
    <name>A0A1Y2BLR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_555851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLR6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLR6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLR6"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="4">
        <location>
            <begin position="265"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="397" mass="43673" checksum="1603F96BB92A5B77" modified="2017-08-30" version="1">MPKSTRSKTEKLKTKSAGASTSSRPSSSTSTPLKTAAPRLYSSFLPIPLSLPSSSSSKPTTHYIYARPHSSKPSSPDDERTVFVANLPVDMTERDLRVVFGRWGVIDSVTFGAESGGDILEDAVRGLPVDDSSDNSESDDEDHEGEREEEEEGEEEEERREPQFIANGKPLSRRQRPRRRKNGLPTSVPDIIPLPSLNPREKPYGLSGLSTARVTYLDDISLTRLFSTSPSSISLPKYNASTSTTKDSSSNPTGLEYYIAKHTSLRPTLASIKAFSDTSMARFDHLHSLLLSSRAKAQGAGALVDEDGFTVVVRGGRYGRTGGRGDGVGKAGVGVARKGFAKDVLEGKKAKKLELQGLYKFQRVDQKRKELADLRAKFEDDKLKVEEMKKNRRFKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLZ7</accession>
    <name>A0A1Y2BLZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_502991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLZ7"/>
    <dbReference type="InParanoid" id="A0A1Y2BLZ7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="378" mass="40485" checksum="2260A6026F108FC1" modified="2017-08-30" version="1">MSMSTEHYVPISTRLFATATCLSTLLSSNGLSNSRPITYLSNKVDRPPEVLSNAILIFTLVTLLVNPEGLASIIADLITYSIGLTSTLSYLRASDRAQKAKNELSKILDFWVVLGGCIVIEGILGRDLIDYLIPLWWVGKVAILGWIMLGSTVPVMLGPTAPTVLDSTIRIQQSLVRSAVAVSTDVGTSIIKTPLSGTFRNNKPSTLNLRSIPRRNSSSTPSEHVPSPEIIRFRNTPDGPEVLSEVEHHNDGYDANSNAVTASSPVFLRHTTGMDGDTVPLAVTDKMSPGESPVFGLTSNNDGIMSDTEDGLLIYSETSGLAQLTESVPVSGGVGEDGMTKISLDQLLEMEMENEGEGEGAEEERKVPKVSQAQAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM27</accession>
    <name>A0A1Y2BM27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_512376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM27"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM27"/>
    <dbReference type="InParanoid" id="A0A1Y2BM27"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000006">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="72287" checksum="11D00E049A7E5A3B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM35</accession>
    <name>A0A1Y2BM35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_511764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM35"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM35"/>
    <dbReference type="InParanoid" id="A0A1Y2BM35"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30903" checksum="938FEC4DE260CEA4" modified="2017-08-30" version="1">MRIHLSLDPNHFNPSGQSSSSSSSSPLIKLGGDLVILELQGELSYEGDDRSGGVVGVIGLDRPDHPTLHLGPHHLLHGKISVLPKPYAVIRRAVGDPNALISIGGTALEGDAEEEEEEDEEGEKDRNISSSTGKKKRKRVETGNTKDKEEQQDEDEDEDEGPLFAPNPDIFDIPTTPQNQRHPNSSSPILPPSSIKDYSSELGYSSPARIDQEDEDEDEEKEEQKDEENRKRARRKERKQAQDGKERTRHYEVVGIVRKKVVFALRPEPIVTATILPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMB6</accession>
    <name>A0A1Y2BMB6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_512897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMB6"/>
    <dbReference type="InParanoid" id="A0A1Y2BMB6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="224" mass="24968" checksum="6C0A088F9FB1687D" modified="2017-08-30" version="1">MPPPQREDERSWDARRDKAIPAEERYREQQKRSGEGSSTSTGLSGLPRRPSSPAQKTRSPSKGSEEYGSSRPRSPAHSLSDIYRRLETRRREDSAEPGQIVSPRRSRSPDIPPPRRDSNPIPRIPSPSSRARPMRSRSPSRREQEGASSRGHTRDGTRKRIRSRSRSPGGDGGGRRRIRSRSRSSPGGGRRRLRSPRSRSPPRDGGILKGEPGSVVLGLEGFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMZ3</accession>
    <name>A0A1Y2BMZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_510493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMZ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMZ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BMZ3"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="444" mass="48621" checksum="089F27C6561F0158" modified="2017-08-30" version="1">MSASSSSSARPKVNLRSTAVKRIMQEASELAKPDEDDFVAGPLESDIFEWHCTMRGVAGSEYQGGLYHLRILLPPSYPMSAPDIVLMTPNGRFELGKKICIDGLTSFHAGSWQPAWGVRTAITGLRSFWMQTGEALSAIGALDYSKEERQRLAGLSRDWACPTCGVKNAELLPDKVEEDDDDSGPPTMEVEGMDSRAHETVPVTQPPTPQLHTTPTEPSIPESPNSPQPLVPALNGLWVQYDISLNPPARLIRLLPNTSRLPGVIPLPPLPAPSSIAPANERWFILPTSDSFTVQRFLPELAPSNSVRVAEGIYPPYPGRHYYTLPSAITHEGRCVFVPADDLPPENALIIRQASDDERAATFDERYPPLGPYPGARGRVFTVSREGRVWAEYVSEGKPPEGALLVSDKQERSTPVWLDVLIGTFVLILAVALAQRTGWILAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BNE8</accession>
    <name>A0A1Y2BNE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein GET1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GET1</name>
        <name evidence="11" type="ORF">BCR39DRAFT_555822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BNE8"/>
    <dbReference type="FunCoup" id="A0A1Y2BNE8">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BNE8"/>
    <dbReference type="InParanoid" id="A0A1Y2BNE8"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010996014" evidence="10">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="215" mass="23899" checksum="17A180AA19D62043" modified="2017-08-30" version="1">MANLALLIFGVVFITQAVSWIGKSVLQELAFSLYARIFLSSLYSKQRTLRSQVLKEKADLAKTSSQDEFAKWAKLKRKVEKSLADLETINSQLGSAKTSFSLRFSSVLWLVTTGAQLVLVWWYRRQPVFYLPQTWTPGVVRWILSFPSAPSGSVSSGAWCTVCKRVLSTLEEIVKDLILPSGVTAPIPTAPVPATSEKTPAARIEPLEIEHDKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BP39</accession>
    <name>A0A1Y2BP39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_585498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BP39"/>
    <dbReference type="STRING" id="71784.A0A1Y2BP39"/>
    <dbReference type="InParanoid" id="A0A1Y2BP39"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="382" mass="42426" checksum="918B0D7AE5773C3C" modified="2017-08-30" version="1">MTPRNNLRKLHSFCTPASISQDSPAARAFRLSAYLAPDTDLVLLDRWEPPQRRRPHEPQSWHLSYHESATRKILSGSDRTPGCHRLVRYSLGGVGVLVTFDCDAYLPQEGELPEGNDTAEDAERREEDEDEDNLSVVTNYTAQTDHTISTVATQGSSQSDDRSDRAFDLWGAKSGPTTSTTTSTGLVIKHTGFVEPPQDALITIKTRGLPLSYRVKKNGPPRFVHSTCSETPSSWEDIHSNKVYSPPNTKATVSSSREPKSIDVESLHQPSKMYEQLLYSQTPTLYLALHHGGDFSAHPLLKLGVHSTELASLRQTHIPIVDKVAGILRFVVDVTRRFGRVGIVGRPDGVIEVRKLDEEVGQLCQETIQILKDAFIRNTAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADN6</accession>
    <name>A0A1Y2ADN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_83261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000131">
        <property type="protein sequence ID" value="ORY20574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADN6"/>
    <dbReference type="InParanoid" id="A0A1Y2ADN6"/>
    <dbReference type="OrthoDB" id="2563735at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012756494" evidence="3">
        <location>
            <begin position="24"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY20574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="488" mass="51401" checksum="C94CAF2CA7D53342" modified="2017-08-30" version="1">MRLSDLASNLAIAVLCSAMTASAASLRQFTWPLSVAQCEVVPVVLLGGTPPFKFYLTPLNGQNMAFELLPPDANSSDAAQYNLQMQFAAGTYYTAWMSDADGIGGGGVTTVSQVAPSNDSSCLGTAQFNLTQNMFAFNLTGALQPCTDPSTGDGMRIEWNGAQEDAPYNMTVIPCDQSYVPFEVPLNYTPSGLAAADWRVNMTSGSRFTVMMNNKFGRGRGGVANVYEVQNASSTTNCASQTRNTDAISWPSSLTAQTLPAATVFIDTGNESNSIGSGAVAGIAVGSALGVALAGLAIFYVFRKRKQSNEDLGQKVNRGGRVDMLDVEKDQDDTPRVDPFMYQGIPLVPTDHDHDHDRQLDSTANSDETPSSSTPFLSASAADLKAQTIELSSRHSTATPSARGYTDLLIPGSSSSGGPSSSPLSPSSKGVLSPSRGTEEQEPAFVRHTDGGSVHEVEGIEPSGGVVDLPPMYSDVPSRSKNEGGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFV1</accession>
    <name>A0A1Y2AFV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_488355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000111">
        <property type="protein sequence ID" value="ORY21421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFV1"/>
    <dbReference type="FunCoup" id="A0A1Y2AFV1">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFV1"/>
    <dbReference type="InParanoid" id="A0A1Y2AFV1"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="6">
        <location>
            <begin position="172"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="287"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="574" mass="63540" checksum="2C2FEA19029B7A5E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFY5</accession>
    <name>A0A1Y2AFY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_474393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFY5"/>
    <dbReference type="FunCoup" id="A0A1Y2AFY5">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFY5"/>
    <dbReference type="InParanoid" id="A0A1Y2AFY5"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="199"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="489" mass="53711" checksum="6FFBD442E42F2D42" modified="2017-08-30" version="1">MQKIAHPPSLDLEGGDENESHYLGSGVFSGLTLREISANSGTSSGTNFQFRQVSFDPRQPAYFVKSKSFMYGRGPTTGKTAFEAVCRESVVAGSDIPTKALSILQRTVLPALPFINATRLETACLGVGDCGPIPYALLAGIIAHSSPYITEMRAIHKTVWSHALLALEDEYRQPRLQTLQLALLAFSARPIYTENAGQSDIGLARAIGAAHLLGLHMEPSNWDLPLWEKSVRKRIWWTLLIHDKWRAVMYGRPSNLHRLYHNVVLPTVTDGDWGKYASPAVQLSLETFVATCRLTLIIELMVETMGELSDWQNSIVVRSAVGSCMRTVNFVLALSGADRESFWMPYSSLHISNSACLLVRIAIQSKSTDADLVAESIRSVILVTEGLLSMYQESAWDVAESALKWMTAILSAACHQLPELKESARAVARALDIPMNSDDISVEEAFSSSDLNFDPMAWLGNDVSWLSADIFNGIPGPESSIEGMQAPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGB8</accession>
    <name>A0A1Y2AGB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_553442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGB8"/>
    <dbReference type="FunCoup" id="A0A1Y2AGB8">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AGB8"/>
    <dbReference type="InParanoid" id="A0A1Y2AGB8"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY21522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="367" mass="40370" checksum="5FB5AFA2D5B18C36" modified="2017-08-30" version="1">MPEVPPKYDVVILGAGVIGLSIALETARRGLKVGIIARDLPDDVHSAAFASPWAGANWASFASNDRERKWDTATFERLGKWAKSHPDMVKRRQVIYPWTTEGVYPEPWYKDIVPNYRKLQPEEVPSGFRYAIGFDSFSIHPHRFNTFLVAQLRDLGVEFHRRTVSSLDEAYTVLGPTRLVVNATGLGARSLIGVADEKVFPGRGQTILVKAPSVQGVFGWKEPHTPIEQQTYVIPRPGPEGHVILGGCNQPRNWDTQPDMAIAERILKEAFQVCPALSEGGASWKDIEVISHNVGLRPCREGGMRLEMEKRIIGQNNSELVPRLGLNGSGCEVACLHAYGIASCGYQASVGVAEEAIGLIVDYFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGC4</accession>
    <name>A0A1Y2AGC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_570433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000120">
        <property type="protein sequence ID" value="ORY20995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGC4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGC4"/>
    <dbReference type="InParanoid" id="A0A1Y2AGC4"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY20995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="560" mass="62795" checksum="692C924BB3D3888D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGZ1</accession>
    <name>A0A1Y2AGZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative exoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_601214</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000103">
        <property type="protein sequence ID" value="ORY21859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2AGZ1">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AGZ1"/>
    <dbReference type="InParanoid" id="A0A1Y2AGZ1"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="11">
        <location>
            <begin position="612"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="800"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="986"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="1288"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="12">
        <location>
            <begin position="1538"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="1882"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY21859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2254" mass="250210" checksum="9E01F74B403D5C74" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH01</accession>
    <name>A0A1Y2AH01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formin homology 2 domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_488464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000115">
        <property type="protein sequence ID" value="ORY21245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="94"/>
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        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:cell cortex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:actin binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0051017">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
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        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
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        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR016024">
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    <dbReference type="InterPro" id="IPR015425">
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    <dbReference type="InterPro" id="IPR042201">
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    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
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    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="237"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="900"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1660"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="690"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="27"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="39"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="832"/>
            <end position="843"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="3">
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            <begin position="1057"/>
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            <begin position="1774"/>
            <end position="1783"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1783" mass="197097" checksum="C8869519E421C010" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHB4</accession>
    <name>A0A1Y2AHB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_553253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000108">
        <property type="protein sequence ID" value="ORY21587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:RNA polymerase II, core complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY21587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="66" mass="7604" checksum="4D54792BB5739218" modified="2017-08-30" version="1">MIIPVRCFSCGKVVGNLWESYLELLAAGVDEGDAMDKLQLKRYCCRRMVLTHVDLIEKLLLYNRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIA4</accession>
    <name>A0A1Y2AIA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_386478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000095">
        <property type="protein sequence ID" value="ORY22319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIA4"/>
    <dbReference type="InParanoid" id="A0A1Y2AIA4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="85"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="461" mass="50903" checksum="477C122A6CA9786D" modified="2017-08-30" version="1">MRADRLVSAARLEPQSQRRRQPQRLPLHLRHRSPSPVSTESTITRLPPASDLGDSVSLVRDEVNPDPVNSEHLRNSGLPTSLPSITTTPFTVTTRFVILDAIWLPEELPFVKQEVTISGATVLNEEQSSTATKLDYLLLPEPHEEIQGGLAARICEGIIMPHLVSLQKVSRKWLKKCILRGRILEAEEKPHAFSNDDLFGKSGQSSTAHPRYSSLPPNQRDLASDVLAEIDRYPFHQNATRSSFYEYYDKAYPRRKPKNIRSFIDRYLTFFEAASPQFASSGRQNARGIGKRSVNGKHPAPAEATPSGSSPLYSASPNPGSQVPLSQISPVVEPVPVVALDRESSTASNPAHLPDPGTLLASASDRRRSHQSVTPDRRSVPSTQGSSHVVSDNHPLEHTVSANDTVNLSPTSSTSIDHHDAASQLLTLARFETPLTTNINQHLALQVWECRLARRAREMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIN3</accession>
    <name>A0A1Y2AIN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyridoxal phosphate-dependent transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_551649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIN3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AIN3"/>
    <dbReference type="InParanoid" id="A0A1Y2AIN3"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY22448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="56129" checksum="935695472C231972" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ21</accession>
    <name>A0A1Y2AJ21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_551318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ21"/>
    <dbReference type="FunCoup" id="A0A1Y2AJ21">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJ21"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ21"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="8">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY22573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="440" mass="46652" checksum="9FFA79AA938909F2" modified="2017-08-30" version="1">MSTEPQPAEPAPAVAETTATGSAETSTGEIPETKADQRAQADKLVAEGKKAIALKQWEEGVSKYADALELMQQLVGDSDPQMAPLLLSYGKALFELAFSQQGVMGKEEVDKQTEETVRQAVIDDTGASSSKIVFSADTVPDDDDAEDAEDAQDARGDTTQDAGGDTTAAGGQGGGEEEVDEPEDDYNAAWEVLDVARTIYAKILEGVPDGEKTEERLCLAECYLSLGDVSCETENFPQAVQDYTSALDIKSAILPPSSRALASVHYQLATVLEFTPDRRSDALSHVEKALSGFRARLSALQSPESSSTVGEMAGKDIAQEIKDVQALIGDLEVKIDELKTAPPAEDLVSESINHLLGSSNGESSTLGPGAGLDDKPVNDLTSMVKKKPKKNGTAQMTAAVQEVKQAVQEMKDAAENTNGAAEKRKAEEQAEGEAKRVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ75</accession>
    <name>A0A1Y2AJ75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_562396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000096">
        <property type="protein sequence ID" value="ORY22247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ75"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ75"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="340" mass="37829" checksum="A4CB09F252982318" modified="2017-08-30" version="1">MSRDATISSELQGSARRLFLQKTLPNSMRFFPSEVTSLKDPTHPPVFAFSQFRPDSGFIDDYTLILEDYTPGCVMLRTGSDSEKTSQLVIERFSHQVFARRLSQQVQFVWTESAIFWDCTSASDAFGIPLYLLPPVLVILGLGRRELSVEALSAVEAWTQNNVLGPSVSPLSLRVPLSNTIKVKGEVLLAICMSVPSSRGIPSRLSGELLRFLAITASDRSDWNGRPIVRRHVGRELFDELVEKEARVSVGEFSYLHASPHSPLSGSNIAVCRLRRRFRRERRSLPSVCKAFQLDLSKQVGVVDAVPPCTIPSNGVQPKFLAALGPTSLECLQSFRMYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKG4</accession>
    <name>A0A1Y2AKG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_365627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Responds to activation by environmental stress by phosphorylating downstream targets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKG4"/>
    <dbReference type="FunCoup" id="A0A1Y2AKG4">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKG4"/>
    <dbReference type="InParanoid" id="A0A1Y2AKG4"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY23049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="410" mass="46772" checksum="D8F9707983EB56A1" modified="2017-08-30" version="1">MATHTQHPSSRRGPPAQADPRAAQGNHQGNPQEKVTKGSSASAPRKIKFNVGNAYHVVDVIGEGAYGVVVSAVHRPSGTKVAIKKVTPFDHSMFALRTLRELKLLKYFASEGVCENIISVLDIIKPTSYEDFREVYLVQELLETDLHRVIRTQDLSDDHCQYFLYQTCRALKALHSANIIHRDLKPSNLLLNANCDLKVCDFGLARSTEAPLNDDKNGFMTEYVATRWYRAPEVMLSFRKYTKSIDVWSVGCILAEMLNGKPLFPGKDYHNQLELILNVLGTPTIDEFNAITSSKSKNYIRQMPFHRKRSFTSLYPNASPAAIDFLTRTLTCASIHFKMMLTYPVDPRTRFTVEDCLRHPYLEAYHDPEDEPTAAPLDRSFFEFDDRKDEITREELKQLLYDEIMDFELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL30</accession>
    <name>A0A1Y2AL30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_549821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL30"/>
    <dbReference type="FunCoup" id="A0A1Y2AL30">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AL30"/>
    <dbReference type="InParanoid" id="A0A1Y2AL30"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="496" mass="54862" checksum="64A0C8517FE2C8CC" modified="2017-08-30" version="1">MPKEQIRKRGKRKSKKDTEAQHDTHLQAAPTEDYIPLEVEVEVEQPQAGPSGLHPARAAMLAGRRPPRPEATIPNPEEEGQPLEWQRGPGIDTDTPFGILDPDLKGYFRTVEDQIKDWEGVSSAGEEREDRQNFLTSVLAELRGHELQVATDPDTAVVLERLLPSLGDWGRRVIGDAFGDNWETLIRHRFGSHVAQTWFTLAADTLDREARGSFPPQQKSQSEIVDNQGVLPTMMTLITTIITSLLPNLPPLLTNPHASPPIRLLLLVISPHKSLPSLDGTGTDSIRSKRSNKYRKGQDVKGKSIFGDDDGKGKGKGKEAQREVPKEVVAVRKEMREVLMQRISGMEWRGMGVEAVGSAAVQLLLELEVEEGESTKPDSILDHLTEGLVTNLKSSPSPQPYPTNLLTTQTGTRLFETTLRVVPQPIFEKVWELYFVGKTGKLAGHPYANFVVAKGVSRLEKDGIEAVVKECRSVSGGRGLISEFIFVHSTSEIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALQ5</accession>
    <name>A0A1Y2ALQ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50B-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_549205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALQ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALQ5"/>
    <dbReference type="InParanoid" id="A0A1Y2ALQ5"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="202" mass="21733" checksum="73138EAD061F39AE" modified="2017-08-30" version="1">MHELCHALAGVLTCAHVESITLDPEQGGSTRMRGGIPAITLPAGYLGSSLIGAGLIACGFDTDASKVATLVLAFFWILTLWWARRSWVAYVTIAIMAGLVIVCWLVAHSVALRFLILFIGVMSCFYAIWDIVDDTLSRKVNTSDASEYARIVGCCGSRFWGAFWLVQASIFFAASLLVGIAAFKDDWGTQASKADNFLGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMT0</accession>
    <name>A0A1Y2AMT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_548909</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMT0"/>
    <dbReference type="FunCoup" id="A0A1Y2AMT0">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AMT0"/>
    <dbReference type="InParanoid" id="A0A1Y2AMT0"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000365">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.14, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY23610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="304" mass="33293" checksum="5C604C16BCC28C93" modified="2017-08-30" version="1">MPPSQAINGEPSSKRQRPNVGSALKKPPAPSYDQGLAYWDGIEASVDGVLGGFGNGPVPHVDQLSSRLLLLSLIPSLGTFPNPLTPSPPPTPSHRLTALDVGAGIGRVSRHVLLPLFEDVITVEPVGKFIDEGYRQGRDREWADLQRQKESGRGKRVWFVKGGLQTLDPRYPAKNGEVVGVVGEARGGDTVAFGEAEAEVVYDAIWCQWCLGHMSTPDLITFFKKAQSALRDNTESFVFVKENCCDDAPGGTGQEFLDEEDSSLTRSHQKWLDIFKEAGLEVVREEVQEGLPDELFVVKTWALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN44</accession>
    <name>A0A1Y2AN44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mitochondrion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_548097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY23998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN44"/>
    <dbReference type="FunCoup" id="A0A1Y2AN44">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AN44"/>
    <dbReference type="InParanoid" id="A0A1Y2AN44"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="228" mass="24471" checksum="CA0E799568D301B6" modified="2017-08-30" version="1">MSNFLRTGRKIVAIGRNYADHAKELGNAIPKEPFFFLKPTSSYISPGDGPVEIPRGTIVHHEVELGVIIGKTGRDIPKSEAESYIAGYTLAVDMTARNVQDAVKAKGLPWSTAKGYDTFCPVGPFIPKSKITDLSKVGLSFSINGNLKQSGTTADMIFDVPHLISFVSGIMKLEEGDVLLTGTPKGVGPIGPGDKFQAKLTYPGLDGQVLDQYEMACEARSGGYEFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN61</accession>
    <name>A0A1Y2AN61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BCR39DRAFT_548191</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN61"/>
    <dbReference type="FunCoup" id="A0A1Y2AN61">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AN61"/>
    <dbReference type="InParanoid" id="A0A1Y2AN61"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="154"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORY24018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="372" mass="39536" checksum="9CDC97A30D644999" modified="2017-08-30" version="1">MSFARPVPVALIGLGGVGRAVLAQLLSPPLAARFNLVLIANSRLSLSLPLPAAAITPVNYLPILEKHGVPLDVPSIVSVLSRHPDAPGILIDATGSDTVPSLYPQILGMGVHVVTPNKKAFSGEETLYRSIQDASYPNAAALVYGESTVGAGLPILSTLRDLVGTGDEVEKIEGVFSGTLSYIFNEYSKPEGGDVKFSQVIKIAKDLGYTEPDPRDDLSGTDVARKLTILARLVPSSPSLPQGYASVPTQSLVPPILADAQTKEDYLSRLGEGDAYFDQLRSEAANEGMVVRYVGVVDLKEGKVEAKLGKYPKDHAFATALKGSDNIISFHTKRYSPRPLVIQGSGAGADVTAMGVTSDMIKIHERLRTVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANL6</accession>
    <name>A0A1Y2ANL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_548567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANL6"/>
    <dbReference type="FunCoup" id="A0A1Y2ANL6">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANL6"/>
    <dbReference type="InParanoid" id="A0A1Y2ANL6"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="110"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="201"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="351"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="517" mass="55116" checksum="0258D3A4EF95BC42" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANV7</accession>
    <name>A0A1Y2ANV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_547597</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANV7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANV7"/>
    <dbReference type="InParanoid" id="A0A1Y2ANV7"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="266" mass="27564" checksum="8056FBB308049402" modified="2017-08-30" version="1">MDSNHYQSWQQPIPHIGSTSEARQASNSHAGPSTSTYPSPSTQSSAADVTSIPIAGGPLVEPHQDLNEFLESFWTRQMDVVEREDQDGRNAILPLARIKKVMKSDEDVRMISAEVPIMFSKACEIFISELTCRAWLVAESHKRRTLQKSDVAAAISISDMFDFLIDIVPRGEDGAAGAGGGGGTGGATSRDDAEDAHGTDHDGVDIVGNGESGGSVGGGGGVGGGGVGSGGVGDDGQGQSDGYGNDSADVQDQGEAMYSEYVQGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP17</accession>
    <name>A0A1Y2AP17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_450890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP17"/>
    <dbReference type="FunCoup" id="A0A1Y2AP17">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AP17"/>
    <dbReference type="InParanoid" id="A0A1Y2AP17"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY23695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="265" mass="29288" checksum="BC87298C332F2B48" modified="2017-08-30" version="1" fragment="single">MPWDTVTLNDGTKIPSIGFGSAFHTKERTIADLGTAIEVGFDHIDTSDNYKNEEEVGQAIKESGLARSEVYLTTKYSVLDKSPSESVEESLEKLGVTYVDLYLIHAPRFCRGDIPGTWKQMEELVKKGYTKSIGVSNFNVAEMEELLKYSTITPVVNQIQFNPNTLKEQAPVLEFQSRHNIVTEGYSPNRPFGTDPGGPVVGLVRDMAARLRVKEEQVMLAWCKAKGVVVVTSSSSKQRMESYLSAGDITLSTDDIRAIDDAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APF3</accession>
    <name>A0A1Y2APF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_546724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APF3"/>
    <dbReference type="InParanoid" id="A0A1Y2APF3"/>
    <dbReference type="OrthoDB" id="2563644at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="675" mass="74270" checksum="1ED94834610CC326" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APL0</accession>
    <name>A0A1Y2APL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_546697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APL0"/>
    <dbReference type="InParanoid" id="A0A1Y2APL0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="157" mass="17957" checksum="92465CCDB8180A2F" modified="2017-08-30" version="1">MPRNAPGTNSHGFLRHRLNTRTPQVNTLPHQIETLNGRRRLDDSRPVPVPDINRPESSSPRQPLTFDAYQLRTLIEQDWRKEACLYDQGLNLFLGIGIQCFAQWGDQYIRLERTKCAATTREAGVGGEIWYCQLQSRWLLMSRCSLHVLVLSVLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQH8</accession>
    <name>A0A1Y2AQH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_561390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQH8"/>
    <dbReference type="InParanoid" id="A0A1Y2AQH8"/>
    <dbReference type="OrthoDB" id="5304367at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="69" mass="7600" checksum="E1D842EFECA8AEE8" modified="2017-08-30" version="1">MSRYRRSDYTMPLAAFGMVIVLTSFIYSSIGNAKINATNSAGSMYGEGGHARQALKKPNNSREEPKKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARM4</accession>
    <name>A0A1Y2ARM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_312260</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2ARM4">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARM4"/>
    <dbReference type="InParanoid" id="A0A1Y2ARM4"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="505"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="810"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1293"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="52"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY24867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1485" mass="166140" checksum="7D841F2D9FE15202" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARU2</accession>
    <name>A0A1Y2ARU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_307452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARU2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARU2"/>
    <dbReference type="InParanoid" id="A0A1Y2ARU2"/>
    <dbReference type="OrthoDB" id="2597019at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012260062" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48737" checksum="663834A50849C814" modified="2017-08-30" version="1">MLSAPTFALTGLTFLLTVAAQDAPDSSTPDASASASASAITTDPSTTANASASAAATSCKYDGSVSAYLSCQKSRISTTTLIVAGIGVTVGIFVIAFLIVWLIKRKKGGKSSQASKHEEDGDGEGSYQKEGEDDEYDQEDEYEEAPRYSPPRNQHAHSIIEKRHAEPQVEKRSSPRTTVVSDSPRHTRVEKIDSGRRRSPRTTDESDTNDDRRVTRVNHNEERRPSRADQNEDRRPTRAESEGRISPRATVSTKPEPAIDTRATTVESVDDPEDDTTPTPRPKPTRSASGSPTDTDITPRDLYPTNPSPLRRPPSSYSRHQPAAQSTRSDPNDAPPMPTAAASGTPPLNVRKSVAPTVGIPSYYETSRPVPSYYEATGRPASRVSTRSRSSESVHRGHGQREREREREPVPPVPGQASDGRRPSAASAKSSSSSGRPRAESRTRGEKGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASS4</accession>
    <name>A0A1Y2ASS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative NADP(+) coupled glycerol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_543507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASS4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASS4"/>
    <dbReference type="InParanoid" id="A0A1Y2ASS4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="321" mass="35535" checksum="069EA616A622E9C6" modified="2017-08-30" version="1">MSVPTEFKLNTGATIPAIGLGTWQAKPGEVRDAVAHALKSGYTHIDCALCYQNEDEVGQGIKDSGVPREKIFITSKVWCTYHDRVEECLDITLKSLGTDYLDLYLVHWPVRTVENGTVKLFPTKPDGSRNIDWEWDQADTWRQMEALVEKGKVKAIGVSNVSEILLEKLSKTWKIVPAVNQIEIHPYLPQHSLKKYCDSKGILLQAYSPLGSTSSPMLSDPEIQEIADKHGVPLATILISWAVNRGTVVLPKSVTPSRIASNLKVVKLDADDMAKLDGMSEEGKWQRINHPPWGTDFGFSDWYGPGNKDAPEGARLLAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AST5</accession>
    <name>A0A1Y2AST5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_543575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AST5"/>
    <dbReference type="FunCoup" id="A0A1Y2AST5">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AST5"/>
    <dbReference type="InParanoid" id="A0A1Y2AST5"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="432" mass="48443" checksum="0C54A95E12655BF2" modified="2017-08-30" version="1">MPRTAKPAKPRHDPLHVELEQDDVHRRLGRVRQPGKRRQRSEKEEDETLAEDARTSKRILDLAREQQDEIAAENEEQWEDDDTEPSRTRERIESSDEEDDDEESEGDVSGDDAELQIDPSDHATLDALGGGGRTLADLIFSQLNSGPQVEDTTENDGPPDPRAGLNPKVIEVYTKVGYLLSRYKSGPLPKALKILPSLPHWAQLLALTEPTQWTPHATYACTKIFVSNLKPSEVRVFLEGVLLDQCREDMRSNGGKLNVHLYEALKKALYKPAAFFKGILFPLCETACSLKEAAIVASVLSRVSVPVLHSAAALLRLASMDYSGPNSLFIRILLDKKYALPYKVVDALVFHFIRLANSPRSRTGEDKLPVLWHQSLLVFTQRYGSDLTPDQKDALLDVIRVRPHPTISAEIRREIVNSVERGAPRPDDVSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATP9</accession>
    <name>A0A1Y2ATP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_484974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATP9"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATP9"/>
    <dbReference type="InParanoid" id="A0A1Y2ATP9"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="383" mass="43010" checksum="5BD5BD874AEEEFF5" modified="2017-08-30" version="1">MPRDDFALSSMSMPPLPVDLPLPPLPHITNTDIYRVILTHGSMYQAVKKFDLTGVDGDKIYDYEKVEHVGDAILGAVVTILLHDLFPRLREGPATILKGLLICNVTLAQLADRYGMTRNLIAAPTSYKVAQNLVKTRGSLFESWVAGVWYSFLEQDIHEILNDEVEELKEDTADSKPSQEEVVRAQESQTSLDEPGPTTVEVDTPDVETANSIVDESKTVIDELQEDKITDLVDPQQTETIPATTLRKTRGQAYDHIDKWLRPLFTPIAHYALGEMQLEQKRIDALAPPPPDVAFEIPQEWASEDRNAVGSCALLHEFAQRKLRSMPFYEDQIARGGMWTVKCILFARDGRKWEEEATRLTKAAAKNVAAWKVYKAIDPQEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATV2</accession>
    <name>A0A1Y2ATV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dak1 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_579530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATV2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATV2"/>
    <dbReference type="InParanoid" id="A0A1Y2ATV2"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="392"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY26018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="599" mass="63836" checksum="83831784D1284952" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU91</accession>
    <name>A0A1Y2AU91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_542247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU91"/>
    <dbReference type="InParanoid" id="A0A1Y2AU91"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="57" mass="6345" checksum="6B352A3C4FACED43" modified="2017-08-30" version="1">MSGIEMFLFVLVQILLQLFIDILIILFLKRLKSGSKVPPTMASAALKNNKRVAGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVA6</accession>
    <name>A0A1Y2AVA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_560538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVA6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVA6"/>
    <dbReference type="InParanoid" id="A0A1Y2AVA6"/>
    <dbReference type="OrthoDB" id="2576237at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1167" mass="126375" checksum="8244E8FCB7289A94" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW35</accession>
    <name>A0A1Y2AW35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_540469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW35"/>
    <dbReference type="InParanoid" id="A0A1Y2AW35"/>
    <dbReference type="OrthoDB" id="2571494at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="166" mass="17947" checksum="1314FBCFD8DB6F86" modified="2017-08-30" version="1">MTTNDDKVPSNPTHSSMRQSISISTTSQAGLPRGRNASLSIARSPSILASSSISDPLSLPHTTSSGGYHNPLTRIRSRSKSRLDDTPFEENGDDEDELDHDHDQIHHHLEETDDNGEGRGDEGLRLVGGPFQKPDMREIMGIVLAVGGVIALSTAAGLTTIYDWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWK2</accession>
    <name>A0A1Y2AWK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_539562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWK2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWK2"/>
    <dbReference type="InParanoid" id="A0A1Y2AWK2"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF32">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G04120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="136" mass="15200" checksum="408588669E3BF583" modified="2017-08-30" version="1">MSETLSGSCLCGGVSVSIPIPPDDSMGVCHCTDCRKSTGTVAGYFLRVSTESFHLDGKEHVKEFTVKADTGNIYRRFFCRDCGSRLWDRDSKETDYVCAGLFPPGTLPKPTYEQFVRHLEKWEKTHEGAKLVQVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWX9</accession>
    <name>A0A1Y2AWX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_448703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWX9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWX9"/>
    <dbReference type="InParanoid" id="A0A1Y2AWX9"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="48218" checksum="3B9506BCA659CCFB" modified="2017-08-30" version="1" fragment="single">NGCLRLIGSVACPGFSYAYLNPGNLSNAFPFFAGVKDVASFDAGALDYFSNQFEFQTTKFIDELGCSNATNAVIRWERTVLCSSWVNEMWSTACLANYNGSAAATSQKMVCQSTCLEYSASEVNIVNSTMFCPGTDNTNGNRSYNLNKDFVDCTNWTTLATNNSMTCVEGTVNEPNCGFGSSSSQLCAFCNSSTPESCCYSSIVCGYTLVPQSSTTGSSSSSTAGASQTGSSASSGSGLSGGQIAGIVIGSVLGGLLLLGLLIFLLCARRRRDRKNSSSNSSFAAGTPHHTSGGVFGGIFHNEPPHGATNSSEKGLLGHSAAAHGSSPTMGGEDTLYSGHKGSNEGSSMMAGGSGGAAAGVGAGGLAPGGQPGERTSGVVLPRVRDENQGGDRWIETGNEVSVLWPYQASLPDELDLRPGMKLKVLRLYDDAWGTAQVVSALSSGEGSEVGKQGAFPIVCVSEGSSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWY3</accession>
    <name>A0A1Y2AWY3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_589428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY27006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWY3"/>
    <dbReference type="FunCoup" id="A0A1Y2AWY3">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AWY3"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="522" mass="58316" checksum="513730C1F2DA014C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX11</accession>
    <name>A0A1Y2AX11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_539140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX11"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX11"/>
    <dbReference type="InParanoid" id="A0A1Y2AX11"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="8"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="433" mass="45991" checksum="111859AB20F9C83C" modified="2017-08-30" version="1">MSLSSVLTAIWTISHSLLYGFHISSLNGVQDSVICGSNKSNRKYGLVSCLDITDAQFGVIVTIFTLGGLLGSLSADTVTRRFGRIGTLRFAEMGLIGGTILVGASNVMALLIIGRLIIGFSSGLVMVSVPLYLAEIATEERRTIFGTLHQIAIGLGMIIGQSLSIPFGQPWKWRAVLLVGLGIALIVFLAGLLVPKPQQTEDKSTEDEDADEETPLVSRENDDTKDEMSVKELFTTPKTKIRRALYVVVAAQLSQQICGISPVMYFSTRILSSVFHGNSKLVTLGIMGIGIPFNFVPGLLPNSFGSRRLLITSAMGTAISSILLAIGLNTHAQALSGVGVVAFVLSFSIGLAPMAWVVLSEVMPPKARTSGGAVGVSVNWLVNFAMGSSFLPLQQALMHGDQGEGNVFFFFAATSALAVVSIWTTFKLLAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX79</accession>
    <name>A0A1Y2AX79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_540022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX79"/>
    <dbReference type="InParanoid" id="A0A1Y2AX79"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="719" mass="79433" checksum="ADF001FC64439AA7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX92</accession>
    <name>A0A1Y2AX92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX92"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX92"/>
    <dbReference type="InParanoid" id="A0A1Y2AX92"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47095" checksum="7EA96101B203A9CA" modified="2017-08-30" version="1">MQRPALMNALRFNPDPPPHLPLPNDLSSRPSRRPYRSNTTTTSSSANLLAPASPERSKMRTRRSLSSDSYGLDAGQKEVAAGQRKTAEDKKASRHADVIDTWDPTGLGSAMWHHSGPYDAAAPSRNTNLPPSKAPMRAFNGAPVQSPPRGPTTISLSSPPVPPSKDLPEGNGHKRAQSAMRAQATRRQSGGLTGQYSTSMPASGGYFPDPDEGTDDASTARRDRQKQRDDKRRALKAAWGTDIPEPFEDFGGSPLGDEMDLTDDMYSPESQTAQLPGRPMRSPGLRMGLGARTPSIKEESSSPTGDFPPQTTYSRGVAQPLPGGGVKRTKSLMQKFKTMVRTRSGSVESQPAVPSVYGRSADRSHSISAGGQRPAISPGIGRPEGQAVVEEELMDEMDDDNQFADAREDVFGTATEMGQWQGSRGERRAMSEGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXY9</accession>
    <name>A0A1Y2AXY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_538029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXY9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXY9"/>
    <dbReference type="InParanoid" id="A0A1Y2AXY9"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="284"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="638" mass="72480" checksum="70A4A003D8ACDA6C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYM9</accession>
    <name>A0A1Y2AYM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_537900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYM9"/>
    <dbReference type="InParanoid" id="A0A1Y2AYM9"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="327" mass="36209" checksum="867A948CAFE6E118" modified="2017-08-30" version="1">MSYCPACQYTKSALYCASCIREGVAKHHQLSNDLRAQGAASSQRARSLIEQPRGIDSWRQLRAQVANAEQRCARLRRAIAKIPDATAPNSRYVAQSSSVENAFLRIRHQQDEVSRRLVHARCVLVREALAVFGVQRDAIAGLPLPPPQMFRLYPATHINAAVLHTLHLLSLLTRYLSIALPFSPSFSTATHVGRPSLRANVPFVTSTKFRDKNVLWMSTRKKNKYFFTSFALLAFSVSYLAWSQGVDGIGVALDEETTIASTQILALMIALAESPRLGIQSHEPGTKLLPHLGFGMDVNLVVDAVLAGEVWEDTEGWDLVEAPRDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYX1</accession>
    <name>A0A1Y2AYX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_537926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2AYX1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYX1"/>
    <dbReference type="InParanoid" id="A0A1Y2AYX1"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="220"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="533"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1288" mass="142197" checksum="79DF575AECF8319A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ72</accession>
    <name>A0A1Y2AZ72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BCR39DRAFT_559773</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2AZ72">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ72"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ72"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="607"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="855"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1436"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="213"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="298"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="399"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="475"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1653"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="684"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORY27879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1717" mass="189630" checksum="AD77B86258ED1EEC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ93</accession>
    <name>A0A1Y2AZ93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_469043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ93"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ93"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ93"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10312" checksum="1CE9535A1CE3765B" modified="2017-08-30" version="1" fragment="single">YSPDNFNANPGDTVRFTFTAGNHTVTQSTFQSPCNASGFTSGFTPVAPGANPPTFDLLINDTTPIWGHCEQTNPVVHCAKGMVFGYVRGVYLVTCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZH9</accession>
    <name>A0A1Y2AZH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_468902</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZH9"/>
    <dbReference type="FunCoup" id="A0A1Y2AZH9">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZH9"/>
    <dbReference type="InParanoid" id="A0A1Y2AZH9"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="276"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY27884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="611" mass="69747" checksum="12AFD3FC4E500058" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZJ3</accession>
    <name>A0A1Y2AZJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="17">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BCR39DRAFT_565503</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="17"/>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY27991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZJ3"/>
    <dbReference type="FunCoup" id="A0A1Y2AZJ3">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZJ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AZJ3"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 17" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="45"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORY27991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="295" mass="32683" checksum="BC349CDD936C234D" modified="2017-08-30" version="1">MADFKSIFALLEPYAQELGGLAVLLTFLAIWLTNRAVPRKVLDPIEWRSFKLAAKDHLSHNTALYRFALPHPNDSLGLPVGQHISVMAEIDGKQVVRSYTPTTLDDDKGHFDLVVKTYEKGNISRYLSLLTVGQDVKIKGPKGKFVYTPEVATHLLMIAGGTGITPMYQIIKSSLKNPKDKTKLSLIYANVEEDDILLRKELEELRDTSKGRFTLYYVLNKPPASWAGGVGFITREMIEQHMPEGGVGSPVHGEGHKVLLCGPPPMISAMKGHLNGLGYPAPRSVSKLEDQVFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B021</accession>
    <name>A0A1Y2B021_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_576720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B021"/>
    <dbReference type="STRING" id="71784.A0A1Y2B021"/>
    <dbReference type="InParanoid" id="A0A1Y2B021"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="142"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="527" mass="57882" checksum="3A4CDFB65AC0103F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0A2</accession>
    <name>A0A1Y2B0A2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_536793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0A2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0A2"/>
    <dbReference type="InParanoid" id="A0A1Y2B0A2"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009385">
        <property type="entry name" value="PRK12744.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="244" mass="25983" checksum="C3CD212B2B688BCB" modified="2017-08-30" version="1">MSKIAVVAGGAKNLGGLISKSLGADGYGVVVHYNSPSTKEAALSTVHEIKSKQGQAWAVQADLTKVAKVEELFAFAKDKGKVYLAVNTVGKVLKKPIAETSETDYDSMFNINSKAAFFFIKSAGAALEEGGSIVSIVTALLAAFTPFYATYQGSKAPVEFFTKSAAKELMEKKITVNAVAPGPMDTPFFYPQESDDAVAYHKSQGLGGRLTKIEDVLPLIKLLTTGQHWITGQVIYTNGGYTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0G5</accession>
    <name>A0A1Y2B0G5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_535429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0G5"/>
    <dbReference type="FunCoup" id="A0A1Y2B0G5">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0G5"/>
    <dbReference type="InParanoid" id="A0A1Y2B0G5"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001277">
        <property type="entry name" value="Elongation factor 1 alpha-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000107">
        <property type="entry name" value="Related to translation elongation factor HBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="195"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="629" mass="68092" checksum="AD2A5DA924EE80B0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Z5</accession>
    <name>A0A1Y2B0Z5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_588711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Z5"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Z5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="153" mass="14517" checksum="4398E99C0D8DD26A" modified="2017-08-30" version="1">MGTVLRLRGGGSCMSKKHHDEDIPLTSEATSYPDTGPKSAPTENTANHNDQTTAPFLPPTVIVTDEHAKHTTWDGLEDTHRNGGNPSVGQREWGGGGPESDAVEAGVEGVGGEAGGGGEGGGGGGESGGGGGEGGGGGEGGGGGGGGEGGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2U0</accession>
    <name>A0A1Y2B2U0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative MFS alpha-glucoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_559212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2U0"/>
    <dbReference type="InParanoid" id="A0A1Y2B2U0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="79"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="580" mass="64191" checksum="EEEB33A10521DC5B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B309</accession>
    <name>A0A1Y2B309_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_532677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B309"/>
    <dbReference type="FunCoup" id="A0A1Y2B309">
        <property type="interactions" value="551"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B309"/>
    <dbReference type="InParanoid" id="A0A1Y2B309"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="231"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="363"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="440" mass="47227" checksum="3DEF59336E62A49E" modified="2017-08-30" version="1">MPGLNPSQQDIEDFISITNSSTEQATHFLATGTTLQGAIEDYFAAQGAEDPEQVEDTDMPEPEEPPRAGGGMTLDGRPAEGLPEGWGRPERTRVGRVGQWSDAPRTGELATLGHDDDDDEDEDPRRPQEFYTGGERSGLAVQNPDAGRRGPGGLVDNILRQAASATRDREPEATTTTPFFRGAGNTLGTDETPAPSEAAPGPRVAPVSSSAFDQLLASMTGRAQSQPEPEPQTRQLIFWRNGFSIEDGPLHPYDNPQTQELLEAIQSGRAPPTLFNVRFDQPLTIQVSERRKEDYHVEKKPAKAFEGSGNRLGSPTREAIGSSSSMAMPGGILQGQGSSSSSTSTSTPAPSAPTSAASFAVDDSKPTTSIQVRLGDGTRLVARVNLTHTVGDLRNFVTASRPDNRPFVLQTTFPSKELSDFNATIEEAQLKNAVVVQRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3X4</accession>
    <name>A0A1Y2B3X4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_574817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3X4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3X4"/>
    <dbReference type="InParanoid" id="A0A1Y2B3X4"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="395" mass="44904" checksum="3ACB1CE9731306A0" modified="2017-08-30" version="1">MPVKTTPRTKMVSIGAWTLGETLGRGAYAHVRLATHANGHQAACKILPALHRPRRRPLTTNELMDAVEAYKEVVILKGLAGSGTQGIVGLEGIMEENGWTYIFLELYPYSLSSVPGPWPARELVPFYRALLHTVHNLHTLDVCHEDLKRSNILVDHERHPVLVDFGFSHLAVDGEVVKSAGGTLDYSSPEKIASQRLEEQDMQDMTSQRYDPRSSDVWALGIVLTKMLGMPHPFLTGSDDEASDDFRKRIIECDPRIDVPPLKSDASEHLVSLLEGILEKDPVQRLTIPQILQHPFVYASHGDPPPFSPPSYQLSPRVKRRFDASVIRDLCFLSYLRKEFRLCQTPMDVEQRLYGDEPGWLKRWAVMLSRWRQRAEMDWEDTVPRVLEINVRRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B556</accession>
    <name>A0A1Y2B556_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_466963</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B556"/>
    <dbReference type="FunCoup" id="A0A1Y2B556">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B556"/>
    <dbReference type="InParanoid" id="A0A1Y2B556"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="146" mass="16095" checksum="1D8D25153CDF50C0" modified="2017-08-30" version="1">MERFTQNPTELLRIVNMVVGGFAIAGGIGSAIHHSFSSIIIGVYEILTGAIIIFLEVRAPTEHQKTLIHKYASFMHSFIGRGVFYLLLGVLMLNYYTILYICGTVVGVVGIAYIALNFFPVFEPPSTMKAPEIDAESQPVWQGPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5H6</accession>
    <name>A0A1Y2B5H6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_531080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5H6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5H6"/>
    <dbReference type="InParanoid" id="A0A1Y2B5H6"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="664"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY29800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="798" mass="87497" checksum="E683966A14842253" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5L0</accession>
    <name>A0A1Y2B5L0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Peptidase family M41-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BCR39DRAFT_530383</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5L0"/>
    <dbReference type="FunCoup" id="A0A1Y2B5L0">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5L0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5L0"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="358"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="765"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORY29976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="818" mass="88072" checksum="3306691A286CD0C1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6D6</accession>
    <name>A0A1Y2B6D6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_530749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6D6"/>
    <dbReference type="FunCoup" id="A0A1Y2B6D6">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6D6"/>
    <dbReference type="InParanoid" id="A0A1Y2B6D6"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="138" mass="14847" checksum="D6D9530766D6C18B" modified="2017-08-30" version="1">MPSHPNEKDNLTTTAVIYKPGPHAAEYIVYIDDSRDYEAWKGDKSIALSRFVGDFAIFKSQTSGHTGQVGEVSKQEIETAFFGDDKNVKDKSVEAAIVIILTHGHAAPASFNSGHKLNKNPGRGLGDVNVSGGPNHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6P3</accession>
    <name>A0A1Y2B6P3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tim17/Tim22/Tim23/Pmp24 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_466598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6P3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6P3"/>
    <dbReference type="InParanoid" id="A0A1Y2B6P3"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="152" mass="15474" checksum="DE7D917625F97367" modified="2017-08-30" version="1">MRSHPLLPPIPSSTSSSHYFFPSPAEAHVYHPKPTLYNTASGGAIGAAFGTVVSAIKNATQQHDKGAIGVFTRTGSSITFFAALVGTYAAAEAITSNVRATEDPWNGAVGGCAAGFIAGIQRKSLPVAVGQCAFMGTVIGAYQTAGVDVSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6T8</accession>
    <name>A0A1Y2B6T8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_153142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6T8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6T8"/>
    <dbReference type="InParanoid" id="A0A1Y2B6T8"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="53"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="266" mass="28815" checksum="924ACB93D33E8DA4" modified="2017-08-30" version="1">MRIPQVLLALLSASSQMTIKPTPYPNHQLFKLNDGNSFPSPAFGCGSALFGKEATDSVLLAIENGYLHIDNSRIYGNEKSVGAALSQTEVDRRKLYITSKYDGINGASVEEEFNQTISELGVDYLDLYLIHFPGAADKGGGIEKVWRSFEKLKREGKAKSIGVSNYDHDQLEELLALAEIKPAVNQIRYHAYNALESASTLAISQENGILTEAYSSLTPITKTPGGPADAIGASIAEELSERYGKEVTVGQTILDWLRSTGVAAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6U2</accession>
    <name>A0A1Y2B6U2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_528690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6U2"/>
    <dbReference type="FunCoup" id="A0A1Y2B6U2">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6U2"/>
    <dbReference type="InParanoid" id="A0A1Y2B6U2"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000016">
        <property type="entry name" value="Putative ubiquitin thioesterase otu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="13">
        <location>
            <begin position="151"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY30552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="37331" checksum="3158DFD893396913" modified="2017-08-30" version="1">MVAIRLRHPRGVTTIEINPETDTIDDLKVLIFSSTEIAVNEQEIKYGYPPKPLPETTGTLSTIPITRGEQVIVTSVPASAAQATSLPHDSAPTPAPSVKPLNEALSAPTEKTPRPSQSQAQPPTPTPAQPSSSAEESSDSVALPGRDAGFLQLRVVPDDNSCLFSAIGVVFEGGIEANKALRKVVADAIKADALNYSDVILGQPREQYITKILKPDTWGGAIELSIFSKHYQTEISSFDVATGRCDRFGQDEYSNRCVLVYSGIHYDAATLAPTPDAPPAFHTTIFPTSDSSILPAAQKLVAQLKARHYYTDTSNFDLRCGVCGVGLKGQKGATEHAKQTGHVEFGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7L5</accession>
    <name>A0A1Y2B7L5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_528583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7L5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7L5"/>
    <dbReference type="InParanoid" id="A0A1Y2B7L5"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="60907" checksum="583173E878500819" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7T7</accession>
    <name>A0A1Y2B7T7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fcf2 pre-rRNA processing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_529116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7T7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7T7"/>
    <dbReference type="InParanoid" id="A0A1Y2B7T7"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="348"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY30600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="470" mass="51587" checksum="8EFA5507FFC600E2" modified="2017-08-30" version="1">MPSTRRSLSHPATPLSVSITPKPTSSRHTPRSASRTPSVQVHHHKTADELALEEAEEMLHSPLASSSRFSTVGTSSSAREARHRHLEQVRAEKEHDREDIDNAESEGDATQVEVAEVNDGRKRFNGGDSRTQEPDETTEGDEVEELAVPDNEEVNTASLSAQDRSSPETTSPPFREPRADDSDPTIGDSSSDSASSESDSEVETSSEDDDDSESDGSSETSDTDDSDEEDERMEALLQAAKTAAKAKQEQAHSRIEVAVAEELDGVLQFDGTEGETHKEKREAPIPDLSIPNLPAPHLSFIADGSAKAPTAAPKVPNAALRKSAEGLELDDRPYEKEPSKREKAAQPKKASASELWATIPAPRSDTLPQMKRDYQALSLANSLDPKRFMKGGNKAGKVPERFAIGTMVEQPRHMQDTTQQRERKYKPGQVVQGLVQDEVVGSYAKRKYGDLQYTRMDNGRGKGWKKRTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B887</accession>
    <name>A0A1Y2B887_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B887"/>
    <dbReference type="InParanoid" id="A0A1Y2B887"/>
    <dbReference type="OrthoDB" id="2559882at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="93" mass="10004" checksum="4ADB76C0FB2C6971" modified="2017-08-30" version="1">MSNAVDPKTQSAVPESVQEAVPKEVEESLPNSVHNTNPQENAHTSHATGQSIVPEAIQKAVPESVERALPNAIHDTGNLECTTYVENVEYVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8D8</accession>
    <name>A0A1Y2B8D8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_529465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8D8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8D8"/>
    <dbReference type="InParanoid" id="A0A1Y2B8D8"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="299" mass="33135" checksum="C6DB306EA71D04D7" modified="2017-08-30" version="1">MGFAHIHHLIRPVDREVEMAKTILVTGATGKQGSGVVRALSAISKNDGSFKILALTRNPSSDAAKALTTLPGVQVIQGDLDDPEPIFSAHKLDGVFSVQDYAAKDEAKQGIAIVDLSVKYKIGQLVYTGVDFAGQENTPLHHFETKRKIEARIHSVPPDALSWTIIRPVGFYENFYWDEWPKAVSTRFSPTANYKLIGCDDIGRVAAHVFSRPEAFNHKAIDLAADSLKQADIAKIWLDVTGKPLPNEKPNLPEAFDKNVEFNATHEFVADVQENRRLFPFLTDFATWLRSTPLAKDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8S2</accession>
    <name>A0A1Y2B8S2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_465905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8S2"/>
    <dbReference type="FunCoup" id="A0A1Y2B8S2">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2B8S2"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000154">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="142"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="242"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY31219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="383" mass="41576" checksum="530DC1F2444C6A13" modified="2017-08-30" version="1">MAPISRDGNSEASTSTSPSLSPPNSLLSHGPLPFDIRIPREFHSMTAGAGAGLMASITTCPLDVVKTRLQAQHLARDAKGYEGVQRTITRIWQQSGARGFYRGLGPTLGGYLPTWGIYFTVYDEVKDRLGVILETQEHPQAGQAATHVVAAMTAGATGTILTNPLWVVKTRFMVTVLPPSAARYRTTFDAIRTIYRNEGFGAFYKGLLPSLMGVSHVAVQFPLYEKAKQWAGAGSHAGLSPSTILICSASSKMIASLVTYPHEVLRTRLQIRTSSPSKSPSRIPPITTVRAPLYSPLVTGSDPPLPIAPPEQHPQIAAPGRTSQKPPWKPNPGGVIDTFLKIKHQDGWRGFYRGLSINLVRTVPNSAVTMLTYELIMRRLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8T1</accession>
    <name>A0A1Y2B8T1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_564683</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8T1"/>
    <dbReference type="FunCoup" id="A0A1Y2B8T1">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8T1"/>
    <dbReference type="InParanoid" id="A0A1Y2B8T1"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="15 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="29"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="387"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY31261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="527" mass="57198" checksum="4B2B5B41306D1A42" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9A2</accession>
    <name>A0A1Y2B9A2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_92097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9A2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9A2"/>
    <dbReference type="InParanoid" id="A0A1Y2B9A2"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012869817" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="142" mass="15443" checksum="D9785C389C3B0FF9" modified="2017-08-30" version="1">MRFSFLASVFLLATSSKTLASPMPEVGIETSSNHLEARATRSSQGWYSYGCYMDCYDGMDRFLPHQAYIDANNSPDMCVAACKDSGYNYAGLQFGKECYCGNTLAGPPTAPSQCDVQCADGHNHCGGPCRNNIWSAFEKPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA08</accession>
    <name>A0A1Y2BA08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_89083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA08"/>
    <dbReference type="InParanoid" id="A0A1Y2BA08"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="104" mass="11536" checksum="B61F21E29FCE145E" modified="2017-08-30" version="1" fragment="single">MALETSQAGPSTVASTLHPGASAYHESSHFKHWRYSPAQLAAVRQALNEKSRDVTAQNIEREKEAQLELGHESAEPPQPTEYPSVEDESLLLRFYATQISAVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA11</accession>
    <name>A0A1Y2BA11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA11"/>
    <dbReference type="InParanoid" id="A0A1Y2BA11"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="92" mass="10969" checksum="28895F3A86379266" modified="2017-08-30" version="1">MKRKVHRHFLQPTPSFLLHFAAMTLQRHSNIQKPMALHHRVWFCSFSSGFLTSCVLILIHTRPLDYVKLLAPYYREDNTCSNLFQLFLLEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAU3</accession>
    <name>A0A1Y2BAU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RPS22A-ribosomal protein S15a.e.c10, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_524788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAU3"/>
    <dbReference type="FunCoup" id="A0A1Y2BAU3">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAU3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAU3"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="130" mass="14532" checksum="7AE43DB75CF4F108" modified="2017-08-30" version="1">MVRVSVLNDALNNIVNAERRGKRQVLIRPSSKVVVKFLSVMQKHGYIGEFEIVDDHRGGKIVIQLNGRLNKTGVISPRFNVAVDAIEQWVNLLLPARSVGKIIMTTSSGIMDHEEARRKHVGGKILGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB72</accession>
    <name>A0A1Y2BB72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_524096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB72"/>
    <dbReference type="STRING" id="71784.A0A1Y2BB72"/>
    <dbReference type="InParanoid" id="A0A1Y2BB72"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="726"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="643"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="757"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="835"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="847"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="940" mass="100174" checksum="9A7EA00D94059EF6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBB5</accession>
    <name>A0A1Y2BBB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_479273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBB5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBB5"/>
    <dbReference type="InParanoid" id="A0A1Y2BBB5"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="243"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY32119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="871" mass="99084" checksum="D5044858DDD74AAC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBE8</accession>
    <name>A0A1Y2BBE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_524353</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBE8"/>
    <dbReference type="FunCoup" id="A0A1Y2BBE8">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBE8"/>
    <dbReference type="InParanoid" id="A0A1Y2BBE8"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="164"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="476"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY32149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="541" mass="60994" checksum="EF85EF95ADEEB2F2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBW8</accession>
    <name>A0A1Y2BBW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_523979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBW8"/>
    <dbReference type="InParanoid" id="A0A1Y2BBW8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="144" mass="15704" checksum="8F94012F0D3671C8" modified="2017-08-30" version="1">MVHILRFGISPENQESLNKTCYSPFHEYALSNLCSQSSLSILDNRDNPINQNQSINTLIIISQEKEEKNSTYGCSNPPSVLPILSPSSQPIIFNNLCPILPSPILSAPCPTRSPSLCRALASGAPNFFAPRGLSFCPPPPPPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCF2</accession>
    <name>A0A1Y2BCF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carboxypeptidase s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_465371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCF2"/>
    <dbReference type="FunCoup" id="A0A1Y2BCF2">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCF2"/>
    <dbReference type="InParanoid" id="A0A1Y2BCF2"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="248"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY31765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="535" mass="58436" checksum="54D7FB1E999F0782" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCJ5</accession>
    <name>A0A1Y2BCJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_564285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCJ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCJ5"/>
    <dbReference type="InParanoid" id="A0A1Y2BCJ5"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="244" mass="25935" checksum="C20D3403D0953195" modified="2017-08-30" version="1">MATETATAPNGDVPSFKIVSRLDGIPVVHDSVTYAHHLVNSYSLTASIYQTAVGVASKSYEIATPVLSRGKPVLESVDGLAVATFDRAEATFPYPFKTPTGELVGVKQAKGIYDAHAQPVLHDVLVKTSEINSALGARAHATLHSSQELSHALIEQLKQLSEQGKAIPSVLLQATGSLAGDVKEIVFSKEGTVQEKSNKLGAYVVDQVKPVIDEIYTYVLGAKKKAEEQTGKAVDQVNGQLNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD48</accession>
    <name>A0A1Y2BD48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_524944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD48"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD48"/>
    <dbReference type="InParanoid" id="A0A1Y2BD48"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="102"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="373" mass="39977" checksum="F3A641CDE1ED6076" modified="2017-08-30" version="1">MSSMIIPRALRVRSTVLVHQRPCHQSFRALSTTFSCLAKPPPPTTHPTQHEDRNVQSGKPVAEFAKEDETKVSGLPEEPKEGGPPPPLAGKTVTELFSLSNRTVIVTGAARGLGLTIAHSLLDAGANVVAIDRTPEPADEPWSDALKLASSKGLKLSYHSLDITDQASVSSLFENLFASAPESAPVRGMFHAAGIQLLMSALEFPADKFRGIIDVNINGSFFVSQAFAREYLKWKENKTKAKAKAVGNEEDLDGASIVLTGSMSGHVANFGLECAAYNASKAGVNQLVKNLAMEWGKQGIRVNSLSPGYIRSAMTAQLLAQKPELDDIWHRGSLLGRLSTPDEFRGPVLYMLSDASSFMTGADLLVDGGHTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDW0</accession>
    <name>A0A1Y2BDW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_522337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDW0"/>
    <dbReference type="InParanoid" id="A0A1Y2BDW0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="194" mass="21972" checksum="807FE97B7508547F" modified="2017-08-30" version="1">MCYGSFFSLSMMSNPTGTYLKKHEETLGNPYNYSSLQNLVNNKDLRFAAMVEEGNRHACLMVVMGKNMFLKSGTSTECVPFGAESVIYLRIDGQTHARPTFTGIAQYRSQTVPDQDWLETLRQTTHENLKAYVEYDRSFEVSNAFAVWGFINRLRDSHSDFSQGMTKALELPSSIVLQSSLDPSSRYLSSMEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE15</accession>
    <name>A0A1Y2BE15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyruvate carboxylase</fullName>
            <ecNumber evidence="4">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BCR39DRAFT_330344</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE15"/>
    <dbReference type="FunCoup" id="A0A1Y2BE15">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE15"/>
    <dbReference type="InParanoid" id="A0A1Y2BE15"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="72"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="192"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="18">
        <location>
            <begin position="610"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="1145"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORY33078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1227" mass="134112" checksum="A4D9151AFF8C8100" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE51</accession>
    <name>A0A1Y2BE51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Timeless protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_592891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE51"/>
    <dbReference type="FunCoup" id="A0A1Y2BE51">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE51"/>
    <dbReference type="InParanoid" id="A0A1Y2BE51"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="6">
        <location>
            <begin position="60"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="925"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1058"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1094"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1118" mass="126742" checksum="5E22C90A61BBB919" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEG4</accession>
    <name>A0A1Y2BEG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_557480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEG4"/>
    <dbReference type="FunCoup" id="A0A1Y2BEG4">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEG4"/>
    <dbReference type="InParanoid" id="A0A1Y2BEG4"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="219" mass="24027" checksum="79F92C29DBB775B2" modified="2017-08-30" version="1">MFTARFPELKRLFDANARWAEEMNEQDPDFLPGTMKGQFPKFLWFGCADSRVPESVLLEQKPGVLFVHRNIANQFHPEDDSANAVLEYGIGPVGCQHVMIVAHTGCGGCIVAHDSPPPAPQAEETTTPLGRFIAPLIELRHSLPAGADGVNDLILANLRRSVENMTKSPAIQTAWELGRKGELQHIYVHGMIYDMASGRLKDLGLSVGPEGPVSLFDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEU4</accession>
    <name>A0A1Y2BEU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_503895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEU4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BEU4"/>
    <dbReference type="InParanoid" id="A0A1Y2BEU4"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY33368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="267" mass="30267" checksum="0F601129477DEABF" modified="2017-08-30" version="1">MDVDAQIDELLSSEEEALVKCEWADCEAAFNDQEGLVKHLHNDHIGAGRDVYMCEWNKCSRRGQKQATRHSLITHIRAHTGERPYTCSVPGCNKTFTRSDALNKHLRSLHDAPIEPPKKKREPSAALTIKPLSLPMAADAELLQDPDLTEVVPRLRARQREWEIDALDKAALATVRSAFSQAAEVDFDEGVSERWPSPVQSVGTVPDPDNPRKLVDVVSRPRWQVRYIMAKAKLMLVDEENAMRRRELAEASALERQAEEEDRTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGM8</accession>
    <name>A0A1Y2BGM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_517957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGM8"/>
    <dbReference type="InParanoid" id="A0A1Y2BGM8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="64" mass="7166" checksum="BA7AD1AB7774FCD7" modified="2017-08-30" version="1">MFGKAPGRSPGESKATTEKKKNSLNPNFQRLPGRDVALAFNLVFLFLLVFRALTVDLFLSRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGY9</accession>
    <name>A0A1Y2BGY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_463645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGY9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGY9"/>
    <dbReference type="InParanoid" id="A0A1Y2BGY9"/>
    <dbReference type="OrthoDB" id="2548929at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="766" mass="84042" checksum="6F9CDD02CE3AC776" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHU7</accession>
    <name>A0A1Y2BHU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromatin associated protein KTI12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_517821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the elongator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHU7"/>
    <dbReference type="FunCoup" id="A0A1Y2BHU7">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHU7"/>
    <dbReference type="InParanoid" id="A0A1Y2BHU7"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000827">
        <property type="entry name" value="KTI12 chromatin-associated homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="304" mass="33731" checksum="D206CBE081B71E89" modified="2017-08-30" version="1">MALITITGFPCSGKSTRAAQLKSNFEARLADPDYTGPSLKVVIVNDESSHVSRSVYDDSISEKSGRANLFTGVTRALGQGSIVICDSLNYIKGFRYQMYCAAREARIRVCTIHVAVPPEKCQEWHDAQTEECSYQQATFDNLLMRYEEPSSMVRWDSPLFTLPFDEDAPYDDIWNVITKGEKKPPPAAVVQIRKPPPNTLQTLTNTTSLIITSLLSHINSAPTMTDTFRIPSPPASTSTSTASSLVLHLPMKRVTLPEMQRLKRQFEGVQTKAQASGSRAAGTWSEEDVAVSFVRFLEATWDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI17</accession>
    <name>A0A1Y2BI17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ornithine decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_518970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI17"/>
    <dbReference type="FunCoup" id="A0A1Y2BI17">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BI17"/>
    <dbReference type="InParanoid" id="A0A1Y2BI17"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000021">
        <property type="entry name" value="Ornithine decarboxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="10">
        <location>
            <begin position="117"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="528" mass="57302" checksum="76777910F7E57957" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ96</accession>
    <name>A0A1Y2BJ96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proteasome complex subunit Rpn13 ubiquitin receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_515196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ96"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ96">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ96"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ96"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="228"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="349" mass="38066" checksum="5D199BF5BE9B6AF4" modified="2017-08-30" version="1">MDLTSRQREQLELLQAAQRRAIQESNLISVPAGRSTRRSPNERWVDPQPDKGFLQMRLEDDLMHLWWKPRGLDVREDELIVFPGEATFEKVGQDSSGRTHVLKFSSSDQKYFFWFQRASTETDLRAEVDINSLLQDPTYRPGTAALPERAPAADAETARSPTPVDARSWPPTPGAPRLSHPEPAPPAEGSSSTNTQAAPAESTQPSEDQTRMDMARMLVEWAQQGGSLTNTDDDARLNDVLSPVNISTLLSTHPNLVSTIAPLLPSELNLPSNPSAQDLLPVLSAPQFTDAIASLENALRSGGLPGGMMRELGLPESAGTGVKAFLDALQALGTGDSPPQNDDDRMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJA4</accession>
    <name>A0A1Y2BJA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_503201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJA4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJA4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="226" mass="25742" checksum="9757228C262BDE9B" modified="2017-08-30" version="1">MGRVTANYPVPQSNEVAPYYSNSTSRQKCMSLDHDWRYSIRFLKDRASGSEMTIGQVLEDVVKNRFKTPNDSLMWCLDPSQDSDQSKDHKDARLSVCLTESCQLVRFCRWSENTPEWRVANTSLSVKAVMTDTRGTVCPHGFFLPARNFDDQINTSFKSKVYTNPNDAYEFWKMEGHEETPLDLATFKITGTYLYPAFLPNTLGLISGGVSVDFCLRMDVDNLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJB3</accession>
    <name>A0A1Y2BJB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_585794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJB3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJB3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJB3"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012440672" evidence="2">
        <location>
            <begin position="23"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="231"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="379" mass="40567" checksum="F444B988E05F62D8" modified="2017-08-30" version="1">MLTIRLLTLLPFLATVLQPGSALPQRGLQFDAEADTNAKTAASSEADKALTISHIPSPSRYKSIKLASRSIPTSGPTEDIDATNTLSTSKDIDDLDGLGETLLEERQGLCVLGDCWSSSLDAPSAPDATNTPSTSKDTDDSDDLSINLLEDREMSNSEGLSPTLSSNDTDDSDGLGESIHCQPPFCFSSSLDAPSDPDATNTLSTSKDTDVSDKNLLEDRSTLCTWWPIKIGCSSLLDQHNGLRQQYGANALTWSNDLQESAQATAATCKFTHTNNNTIGENFALISGPEANFTTAFELWASEAASYNPKEPVYNADYANFTQLVWFSTDQVGCGVANCSEGIETSGWTAGGGLWFYVCHYLEAGNVAGEFSKGVPFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJR2</accession>
    <name>A0A1Y2BJR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_516034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJR2"/>
    <dbReference type="FunCoup" id="A0A1Y2BJR2">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJR2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJR2"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="106"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="270"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="376" mass="42416" checksum="0E3AF27AB11292F0" modified="2017-08-30" version="1">MSTAGPSGIQAHPDSEPEDDSVSPNRQTQTKKRKRHSHIELEDAFRHEDPIQLAKLNAQYRAKQSEAEDNLANLANVTAAEIQKNIKDTNDLFSEVRLSIGVATLDAKVIISSSDAVLGLAQKLKDDNNAFDTDNFMIRIKTLLGLDRLELEDIDVDDEEDEIDESLESGGRSRRNRARKGRIGDWEKVGWMAASLTRRVPGVEFMYGPLAVEHKKRAAPNRQRRGDVAPEQRPEEIDLSKSNTEAKDDTLTNVRIVGKTMEALDPEGEGINLFKLVINPDSFGQTVENLFYVSFLIKEARAGITVKEDGEIFVFQRHQDDVERDTDGRILMNQAVMELDQETWEEAKRIFKITKSAIPHRDYSKLAVPGSRSWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJW9</accession>
    <name>A0A1Y2BJW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_516447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJW9"/>
    <dbReference type="FunCoup" id="A0A1Y2BJW9">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJW9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJW9"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000050">
        <property type="entry name" value="Related to XPT1-xanthine phosphoribosyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="218" mass="24573" checksum="5B2EFECB7BB5E545" modified="2017-08-30" version="1">MGHPEGDVPMVRWSYNDVHKAIQATAVRIKEEFAPTLFIAIGGGGFIPARILRTFCKTTTEGVKRNIPIQAVGLVLYESMGGIAEKPGTEVVRTQWLDFSTLGNMASRGGLLGRKILVVDEVDDTRTTLMYCLRELQSDINKQLDEVEDETERERLRKETQLGIFVVHNKLKEKVGTLPSSIKYFSAVDTPDVWLAYPWECDEDIDEHDSLRSQNPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKL9</accession>
    <name>A0A1Y2BKL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_555472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKL9"/>
    <dbReference type="InParanoid" id="A0A1Y2BKL9"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="78"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="552" mass="60131" checksum="931B8F297AC9A51F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL63</accession>
    <name>A0A1Y2BL63_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_509246</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL63"/>
    <dbReference type="FunCoup" id="A0A1Y2BL63">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL63"/>
    <dbReference type="InParanoid" id="A0A1Y2BL63"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY35390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="363" mass="41339" checksum="437BDF6F1C6BF5BC" modified="2017-08-30" version="1">MTTNGTSTAPQTAANDKAARRKRFEDVFPIIANELLGYIRGEGMPKDAVEWYEKNLYHNTPGGKLNRGMSVVDTVEILKGEALTEDEYLKAAILGWCVELLQAYFLVADDMMDASLTRRGQPCWYKMPNVGNIAINDAFMLEAAIYHLLKKHFRSEKYYVDLLELFLETTFQTELGQLIDLLTAPEDHVDLSRFSLEKHHLIVVYKTAFYSFYLPVALAMRMRGIEDEAAYKLALSILIPLGEYFQVQDDYLDCYGLPEHIGKIGTDILDNKCSWNINTALSHATPDQLSVLESNYGRKDPVAESRVKEVFSQEPIALPRRFETYEAESYTKITELIESVDESGGMKRAVFTSFLNKVYKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL87</accession>
    <name>A0A1Y2BL87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_461392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL87"/>
    <dbReference type="FunCoup" id="A0A1Y2BL87">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL87"/>
    <dbReference type="InParanoid" id="A0A1Y2BL87"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="328" mass="37121" checksum="BE33561CAC8B8527" modified="2017-08-30" version="1">MAPFDLDACIDRLRDKQLLGEALLREICEKTKEVLMRESNVVHVASPVTVVGDIHGQFHDLIEIFRIGGSAPNTNYLFLGDYVDRGLHSVETISLLTCLKLRYPERVQLIRGNHESRAVTQTYGFYLECTRKYGSPNVWQYFTDMFDFLTLSVVIDDAIFCVHGGLSPSIHHIDQIKIIDRFREIPHEGPMADLVWSDPDPEKEDFAISPRGAGYTFGASIVKKFLSLNGMNHVLRAHQLCMEGYSVLYGDQLSTVWSAPNYCYRCGNMASILEVSPGGRRFFNVFEAAPENEVSCRLYLVDMQRDGPNQQQQAKVCDHALQMLMTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLD0</accession>
    <name>A0A1Y2BLD0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_510889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLD0"/>
    <dbReference type="FunCoup" id="A0A1Y2BLD0">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLD0"/>
    <dbReference type="InParanoid" id="A0A1Y2BLD0"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="14"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="322"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="387" mass="44257" checksum="AB70ACE0457B540C" modified="2017-08-30" version="1">MASRTSRGRKQAKKGVQLTVMVVGASGTGRTTFVNTLVDQPLLTHRSQSLLTDPSNLHSPLDISLVRQAAQTAHEEQPINIKPINVELEEDGVRIALTIVDTPGFGDGIDNEYAFQEISTYLERQYDDILAEESRIKRNPRFRDNRVHALLYFIPPTGHALREIDIELMKRLSPRVNVIPVIGKADSLNSLELKAFKKRIMEDIEYYGIPVYNFPYDVEEDDEETINDNSELRALLPFAIVGSEEEIMINGQPVRGRRYPWGVVEVDNPLHSDFSRLRSALLISHLTDLKEITHDFLYENYRTEKLSRSVGGGDLGQSILPEDMANQSVRLKEEQLRREEEKLREVELKVQRDIQMKKQELMAKEDSLKVLEARLGEFVFFFSPVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLH3</accession>
    <name>A0A1Y2BLH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_511164</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
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    </dbReference>
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            <end position="274"/>
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        <location>
            <begin position="428"/>
            <end position="472"/>
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    </feature>
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            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLK7</accession>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Naematelia</taxon>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
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    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORY35642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY35642.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLN9</accession>
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        </submittedName>
    </protein>
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        <name type="scientific">Naematelia encephala</name>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35684.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="618" mass="66323" checksum="AB762B6C34BCE779" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLU2</accession>
    <name>A0A1Y2BLU2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_511761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLU2"/>
    <dbReference type="FunCoup" id="A0A1Y2BLU2">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLU2"/>
    <dbReference type="InParanoid" id="A0A1Y2BLU2"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="255" mass="28864" checksum="A8009DC22A0BE2BA" modified="2017-08-30" version="1">MSVLPYPPLHTEAKFVVLSDWDGTITDRDSNDFVVDNLGFGYEKRRAMNLEVLQEKITFRDSFREMLQSVHHPFEDCKKLLQQNIKLDPGFKEFYEWCKANNVPVIIVSSGMEPNIRAVLSTLLSPEEALKIEIIANDVKFTDPAHTGETWEIVYRHPESGFGHDKSKAILPYRDLPSKPTLFFCGDGVSDMSAAKHADCLFTKLMANGDSDLMAYCKRQGIPHVPFTDFKQVLERVKQVVEGKPVAEVLKEAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM99</accession>
    <name>A0A1Y2BM99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Capsular associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_512729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM99"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM99"/>
    <dbReference type="InParanoid" id="A0A1Y2BM99"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="63202" checksum="19E7C0E5DEEB0558" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AD68</accession>
    <name>A0A1Y2AD68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_488848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000133">
        <property type="protein sequence ID" value="ORY20509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AD68"/>
    <dbReference type="FunCoup" id="A0A1Y2AD68">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AD68"/>
    <dbReference type="InParanoid" id="A0A1Y2AD68"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="123"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="217"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY20509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="304" mass="32571" checksum="1290883198FDA750" modified="2017-08-30" version="1">MSPPVDSKIPGGKRDSGAARIFGSGTSGIAELLVFHPVDTVAKRLMSNRSRVAVGELNNIVFRSAANAPIHKKFMSLFPGLGYAAGYKVAQRIYKFGGQPYFRDMIDKNSGDFFRSTFGKKNGGMLMHATAGSLTGIGEVVLLPLDVLKIKMQTNPGALAGRGFFKLLTDEGIGSLYRGWGWTMARNAPGSFALFGGSAATKEYLFRIEDYASATWGQNFVASIGGAVASITVASPLDVVKTRIQNANFNSTVGGATIIREMIRQEGVGAFFKGLTPKILVVGPKLVFSYTLAQSLIPFFGKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADR3</accession>
    <name>A0A1Y2ADR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_554901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000127">
        <property type="protein sequence ID" value="ORY20708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADR3"/>
    <dbReference type="FunCoup" id="A0A1Y2ADR3">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ADR3"/>
    <dbReference type="InParanoid" id="A0A1Y2ADR3"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000276">
        <property type="entry name" value="Glutaredoxin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY20708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="144" mass="15740" checksum="CF79AA1485E5C664" modified="2017-08-30" version="1">MSAVRRLATLSNHLVTRSLPSQFNSPVATSFKLGSALSTTTSPEMSASVKQLVDSSIADNKVVVFSKTYCPYCRRAKQILTQETDNVKIFELDEEDNGSEIQAYLKQLNGQGTVPHVYINKEFIGGCSDLQAIPTAKLKQKIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEH2</accession>
    <name>A0A1Y2AEH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_601404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000121">
        <property type="protein sequence ID" value="ORY20951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEH2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEH2"/>
    <dbReference type="InParanoid" id="A0A1Y2AEH2"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY20951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="263" mass="28820" checksum="64C9D7790FB43D6E" modified="2017-08-30" version="1">MASSQPFQTDSIRPTSLPSANLGHRVLGASSAEPSANDHDHDQAAEEWNGRIDRELKSLVGGLKELVRVADLTPTPQALSGPLLPLHLSLQTSSLIRSAQNLRDMAHELKLLLLLGDEASTARNRDNEMTRLGIEVDQRRREVVREAVEVFGGGSKLIQSETEGVNDQEAVEGVNDDELLEGVNNGGNVEGDNNGENVEGVNDQEAIEGENVEAEEERRREEENERDGEDKEMSRRDDDGAIGSEDAEEQVSMDIDDDFEEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEI7</accession>
    <name>A0A1Y2AEI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_502348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000121">
        <property type="protein sequence ID" value="ORY20961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEI7"/>
    <dbReference type="InParanoid" id="A0A1Y2AEI7"/>
    <dbReference type="OrthoDB" id="2595278at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="120" mass="12948" checksum="6E08FA9967DD7BC8" modified="2017-08-30" version="1">MKRESDSSPPSTPPSKSALTPNTTPTPTKRLKSTPSSKTKTKTDNDTEKIDPSPGKGRSTKLTLAAKAEFLEDIIAAGVRAVNMDTLALKYGVPKSVLVDQMKPNRSNLRERAIKAIRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFL2</accession>
    <name>A0A1Y2AFL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_569930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000114">
        <property type="protein sequence ID" value="ORY21296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFL2"/>
    <dbReference type="InParanoid" id="A0A1Y2AFL2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="356" mass="39262" checksum="A0D109C5D78BF7E3" modified="2017-08-30" version="1">MDISPAFLVHHSLSVTSALEPYDVFRGTQSTMTKSQSSNSGVTSNRTSLATLVSMMRKIQNARSVLQAGLRSPPSTFASREQPRVDDTSRPSLSHEVTSTTPSLPSTSPVLPSTSPPLPSTTTTPSLAFSKTQMARGSVLLRLPLQVSHVGTSQAGRANQTKFESLQHSVDGLALDDRTTLAELASISNAYQELYSAIREENPQDRWRLTDDAAKKLYGVVWETNERLQGTVQASQTDGQRTTTMDRPITTASNTYWKPWDKRQDKEKGKADPEETEATEDTKEDTKEDTEATEETEGAYYLGGTGECTVQLYRQLKVQHSIHPGEGSIPPKKIKDDLSIERRCQYLGHQATQSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGB1</accession>
    <name>A0A1Y2AGB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_553817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000113">
        <property type="protein sequence ID" value="ORY21330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGB1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGB1"/>
    <dbReference type="InParanoid" id="A0A1Y2AGB1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000039">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY21330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="176" mass="19192" checksum="1820E3D28E1E2038" modified="2017-08-30" version="1">MASSSLDAPPGVTRPVVFFDVNIGETPAGRIKMADSGRTAENFRQLCTGEHRINSTPQGFKSSTFHRIPQFMIQGGDFQRNDGTGSFSIYGAQFEDENFVVKHTGPGLLSMANSGPNTNGCQFFITCAQAEFLDGKHCVFGRVIEGLLTVRKIENVPTGPNNRPKLICRITECGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGM6</accession>
    <name>A0A1Y2AGM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">X-domain of DnaJ-containing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_554217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGM6"/>
    <dbReference type="FunCoup" id="A0A1Y2AGM6">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AGM6"/>
    <dbReference type="InParanoid" id="A0A1Y2AGM6"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="498" mass="54526" checksum="0B4B2842A0BC82E8" modified="2017-08-30" version="1">MSKKVKDTELYDVLGVSPEATDIELKKAYRKKAIQWHPDKNTSPEAEAKFKEIGEAYQVLSNPDSRAFYDKVGRAGMDKTADDAQVDPQEIFSKMFGGEAFYDYIGEISLVKDFTSTMDVVMTPEERAEMEAAEQESAENAQGTTPTAASVAAATSSADVSPTTPQASATPTHSATTEHSNTSLAHHSSFGPNSSASTSDLSKKEQSSTPGKDKKGKPKLSPEQKAQLDMLEKKQEERKLARVKELQEKLVQRIRPFVDAKHPGDINDPETKAFEGRIRTEAEDLKLESFGIELLHTISGVYITKAGNFVKAKKFFGGGFLGRLKEKGGMVKEGWGLLGSAIGVKTAMEEMERLEQKGDATPEELEALAQELSSKMLLTTWKATRWEVINVVGTVVDQVLYEPGLSKDVALKRAKAIMTIGGIFKSVEADESDEERRELERLVMNAGNKKKKAEKEKEKEKDKKGWGWGHSQSTKTDSAPATPPTGEKATTSGHSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH36</accession>
    <name>A0A1Y2AH36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000104">
        <property type="protein sequence ID" value="ORY21792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH36"/>
    <dbReference type="InParanoid" id="A0A1Y2AH36"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="573" mass="61165" checksum="93AEA840A1DB4EF2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI28</accession>
    <name>A0A1Y2AI28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_551983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000096">
        <property type="protein sequence ID" value="ORY22249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI28"/>
    <dbReference type="InParanoid" id="A0A1Y2AI28"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="241" mass="26778" checksum="2465378DB6EA7DED" modified="2017-08-30" version="1">MTGSPFSVAGGLLPFAHYISVPAASPSTADNDSVLPNASDLPAVAPISWRSRWPFKVTAEQGKGHDYDLIRELTPTKLTTPPRKRRRLSSQPEVSIPLPCTVEGELVRFQNMLMEVNRGLQEDAIPRFRRSLENVIEQSVSQRVEAALKEERERLEQMKAEIMEREQNSNQQIQSTRPILRIPITGSDYLIPVPTGDDGSECDLESQCSLLHAILKARDIEVSALRDRLKSLEGSAGPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJD2</accession>
    <name>A0A1Y2AJD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hemolysin-III related-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_550932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000089">
        <property type="protein sequence ID" value="ORY22683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJD2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJD2"/>
    <dbReference type="InParanoid" id="A0A1Y2AJD2"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="705" mass="77111" checksum="40306A9CA379DE2C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJE3</accession>
    <name>A0A1Y2AJE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_583976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000089">
        <property type="protein sequence ID" value="ORY22699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJE3"/>
    <dbReference type="InParanoid" id="A0A1Y2AJE3"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28645" checksum="D8C2A62AA4B6C4CE" modified="2017-08-30" version="1">MSVMRDTPGQKELVKLQEYMNNQPDVLTAIVKYRLKTPGNLGDIFIESFDPQGHHIVLLTHPLPSREPVKLLLPFHQPITSPYEVRPWLYTWRDQALKHFNVPERPVVDYYSPPSPFPFAVPGVLGLLALLFALVGPGPYAVQWRNFLDARLGKKGIPAITYFVVFMHFIFWPIFMFWTLRKHKVPLEPGIKWMITATVLGIGCGTEFWETVQYERLRHVYRQTDVGEIEPRVGHGRGGGKVSSEKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJT1</accession>
    <name>A0A1Y2AJT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_550650</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJT1"/>
    <dbReference type="FunCoup" id="A0A1Y2AJT1">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJT1"/>
    <dbReference type="InParanoid" id="A0A1Y2AJT1"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053974">
        <property type="entry name" value="ERMP1_1-A_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22249">
        <property type="entry name" value="ERMP1-TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="140"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1/1-A TM" evidence="17">
        <location>
            <begin position="397"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY22823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="846" mass="93889" checksum="5B6F238DFDBFB376" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKN9</accession>
    <name>A0A1Y2AKN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_549970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKN9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKN9"/>
    <dbReference type="InParanoid" id="A0A1Y2AKN9"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY23129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="64009" checksum="19EFB9630CED6DE3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKT6</accession>
    <name>A0A1Y2AKT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_473602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000086">
        <property type="protein sequence ID" value="ORY22910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKT6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKT6"/>
    <dbReference type="InParanoid" id="A0A1Y2AKT6"/>
    <dbReference type="OrthoDB" id="2594556at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="127" mass="14928" checksum="F91C2713D97ECDEB" modified="2017-08-30" version="1">MFAAFAKGFGDGQRGHDQVRAMAIMWMREHPQDFIPFVPDSYKGQSQDFNCYLLRMSQLGEWGDNLTLQAMCKAYRTHVHVLKRGQKGDLVWMEIGDRVKPQSVFWLYLDKYHYENLLDRSQISFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL98</accession>
    <name>A0A1Y2AL98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_549350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL98"/>
    <dbReference type="FunCoup" id="A0A1Y2AL98">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AL98"/>
    <dbReference type="InParanoid" id="A0A1Y2AL98"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF21">
        <property type="entry name" value="DNAJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="225" mass="24115" checksum="AC13DC690C70F2F7" modified="2017-08-30" version="1">MSSLPQYYTILNVSPTATADEIRGAYKRESLKTHPDRLPQSATPQERRRATERFQAVADAYYVLSDPARRAEYDALFRSRPSSAFTDDNASEFEQDQASSSFFSNFSNFFQNATGTAGAEGTEGTQARPDANNVFGDVFEEMLAPEVQHVRPFWAWVGGGAGGALGYIVANIPGAVAGGFAGNRLGAIRDAKGKSVAQVFGGLNSAKKAEILRALAFKVLGSMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALH3</accession>
    <name>A0A1Y2ALH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo-type protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_549413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALH3"/>
    <dbReference type="InParanoid" id="A0A1Y2ALH3"/>
    <dbReference type="OrthoDB" id="2573735at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY23356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="90231" checksum="670A7C3AC17754E0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALQ1</accession>
    <name>A0A1Y2ALQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="6">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_549837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALQ1"/>
    <dbReference type="FunCoup" id="A0A1Y2ALQ1">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALQ1"/>
    <dbReference type="InParanoid" id="A0A1Y2ALQ1"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="9">
        <location>
            <begin position="270"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY23220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="419" mass="45238" checksum="99DBD5C8D1AC2695" modified="2017-08-30" version="1">MTTTPTNTITPPRPTTIFSRTSFQGASKEMSFSSVPASPPTQALSEMDIGSTVTTPAVTRPSSPIEALPASPLPSGKHRVAIIGSGSWGSALAKIAAENVWKHRDDFHREVRMWVREKHVNGKKLTEIINRTHQNSRYLPDIALPKNLVAVPHLKDVVKDATLLVFVTPHQFLHTVLRELAAPGVITPGARAITAIKGVEVNGTDIQTFASLIESKLGTPTSALSGANIAIEVAQEQFCETTIGVPSESDAKLWYSVFHSTNFHVSCIPDVAGVSLSGALKNVVALAAGFVDGLRLGGNTKAAILRIGLQEMKGFCMEFFEGSKPETFSDESAGIADLITTCYGGRNRKCAEEFVKTGQSFDKIEQKLLNGQKLQGTATAEEVNNFLVARKRAHAYPLFEKVYQISFKGVSPQEIVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM96</accession>
    <name>A0A1Y2AM96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_561848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM96"/>
    <dbReference type="FunCoup" id="A0A1Y2AM96">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AM96"/>
    <dbReference type="InParanoid" id="A0A1Y2AM96"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="251" mass="28100" checksum="7218D083EB4DA809" modified="2017-08-30" version="1">MPIVTFFLGVWQVKRLRWKLDLIEEIERNIEREPMLLPPHVNLTALPDFAFRRVLLKGHFEGPPLLFGPIVEQGFPGYALILPFVRSPLPNSTTVPSTILVNRGFITKTRAEGIKAGTEPVPGLKDGEVVIEGMLTKRFTEGKGSWTPENEPEKNEWFWKDAKGMAEFVGGEERGVQPVLVDAIDDGSIPSSYLMQQGIPVGRPPTVEVRNQHATYAMTWFSLSAATAIMLVLLFRRGKGKKVLPTRSLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMN8</accession>
    <name>A0A1Y2AMN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1-gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_549190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMN8"/>
    <dbReference type="FunCoup" id="A0A1Y2AMN8">
        <property type="interactions" value="563"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AMN8"/>
    <dbReference type="InParanoid" id="A0A1Y2AMN8"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="87"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="269"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY23560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47357" checksum="627D7C4682F5ED3C" modified="2017-08-30" version="1">MAPKLIGSAGNPRVSRVLAAAALAGVELDFDSSFTMSSNWKTTEFLQKFPLGTLPVLEDGEFRLSESAAIAEYVASLGPNQTILPSDPKELALVHQWMSLADQEIFIKHAHANGLLIGRFPYSKPTFTAMYEGLLKTLTTVDGILAHKTFVVGERITLGDIILVTAVVKAFTGIVDAAARAKLPNLVRYVETVTKHPKLIAIFDNGNIQYTETQAVYQPPAKPKETKAPKEAKPKAEAAPKPPKAPKAPKEKEPEDDDDEPLVPEEPKAKNPLDDLPKSAFNLEEWKRQYSNLDTRKEALPWFYEKFDKEGFSIWRVDFKYNEELTLVFMSSNQIGGFFNRLEASRKYLFGSVGVLGKANDSIITGVLVCRGSDYKPVVDVAPDWESYEYKAIDLSNSADKDFFEAAMAWDLVIDGREWADGKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMX8</accession>
    <name>A0A1Y2AMX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_548342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMX8"/>
    <dbReference type="InParanoid" id="A0A1Y2AMX8"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY23933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="811" mass="91749" checksum="F25403DC68367BAE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMX9</accession>
    <name>A0A1Y2AMX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_507668</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMX9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMX9"/>
    <dbReference type="InParanoid" id="A0A1Y2AMX9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="19"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY23919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="552" mass="60587" checksum="53F6E4B1D952D4D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN94</accession>
    <name>A0A1Y2AN94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_547829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN94"/>
    <dbReference type="STRING" id="71784.A0A1Y2AN94"/>
    <dbReference type="InParanoid" id="A0A1Y2AN94"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="517"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="994" mass="104125" checksum="20B14E4A68C8229E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANG5</accession>
    <name>A0A1Y2ANG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XRCC4-like factor-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_507593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANG5"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANG5"/>
    <dbReference type="InParanoid" id="A0A1Y2ANG5"/>
    <dbReference type="OrthoDB" id="2564800at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37060" checksum="0FEC657525E372F2" modified="2017-08-30" version="1">MSSFQKKHDDSLIASPWRFKADNNEQTWLFKHAPHPDKAGYLLIATDLNSILFESLTASSIPSRLAALADISPSQRPNTSHSTSDTDVENIASMIEDTLDKIGGLMGDWWDEVTLQIRDDDFYDRIMLLSTEDFTWSFNLTSNRELRDRTPLTFISRHLIQPLSSLLATSYNTKIPHGCSSVNTLARLLSQEGLAEEIATASKSGPSRSTKGKSPAKRARTKDPSPTISRHRVEDIKKEDNGSPGPQTSSSEAVRTSRIATQASPTLKEDISSPTLTPEPTPSPTDTTPEPTPTPLGQSPRPARSRKIIHAYASSPKIAKPNQDPSPSCIAETQSEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANP8</accession>
    <name>A0A1Y2ANP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_547537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANP8"/>
    <dbReference type="InParanoid" id="A0A1Y2ANP8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="70" mass="8125" checksum="F343FD60B11BD76A" modified="2017-08-30" version="1">MTTRQAKEVARTTRRTNRLLPLFLRTMSEVEHDRSLVGSLNEYQYIFRADRLSVSVFVFLAFGGEVEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANZ4</accession>
    <name>A0A1Y2ANZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_343189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANZ4"/>
    <dbReference type="InParanoid" id="A0A1Y2ANZ4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY23675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="143" mass="16044" checksum="3DFDBA1FCCE0D5A7" modified="2017-08-30" version="1">MAKLACSLSNEHWSSTTFLYTSDLTQLQLTFSAVLLLRIIRLTRTWFDQQFIDEAIGEVQASASLLSELKGKYYSDNVKAAITSFQTWLSSRTPSGANSALPVGVENDRQLQDDYFFDLNAMGGLEMGWESFLDQQSIGELQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP29</accession>
    <name>A0A1Y2AP29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_336826</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP29"/>
    <dbReference type="STRING" id="71784.A0A1Y2AP29"/>
    <dbReference type="InParanoid" id="A0A1Y2AP29"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY24050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="553" mass="63648" checksum="F583CEB6C3541A40" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP68</accession>
    <name>A0A1Y2AP68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin assembly factor 1 subunit A-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_546875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP68"/>
    <dbReference type="STRING" id="71784.A0A1Y2AP68"/>
    <dbReference type="InParanoid" id="A0A1Y2AP68"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="7">
        <location>
            <begin position="505"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="8">
        <location>
            <begin position="753"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="826" mass="92567" checksum="98B8FFCAEF9BB7BB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APJ5</accession>
    <name>A0A1Y2APJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_547113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APJ5"/>
    <dbReference type="FunCoup" id="A0A1Y2APJ5">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2APJ5"/>
    <dbReference type="InParanoid" id="A0A1Y2APJ5"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="92"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001467-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="166" mass="18003" checksum="5A020C71B1A99200" modified="2017-08-30" version="1">MAEATYVTFDTSVGSFTVELYTAHAPKTCNNFSKLAERGYYNGVIFHRIIPGFMIQGGDPTGTGRGGTSIYGEKFQDEIHPDLRFVGAGILAMANSGPNTNGSQFFITCAPTPYLDGKHTIFGRVSSGMKTVQRLEAVRTDANDRPVEDIKIHKARLGDGKPLAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APN8</accession>
    <name>A0A1Y2APN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carboxypeptidase C</fullName>
            <ecNumber evidence="2">3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_600479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APN8"/>
    <dbReference type="InParanoid" id="A0A1Y2APN8"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="496" mass="54991" checksum="82165989046F72EA" modified="2017-08-30" version="1">MSNAQETTPLLGEEAGKPTKRYGWHYVLAGVAFVLVTAAVIVSVVLSVRHSPKAYAPGSFFVNITKAPSFCDAPATAWTGHIGLTGDTEESPKRSFFWYVEAEKKPETAPMVLTVGGGPGTSGLTRMWLGDGPCIISQEEKRAVSNPDRWTKEFNYLAIDHPVGVGFSYGQMVNSSADAARDIYDFLQRFYSLHPDLQKNDLILNGGSYGGMYLPHMAHEINEQNKLLALGKAKSGTKHINLESIMISNPMLDPISHITGLPLSMCKYHQIWNETECTELYEAVPSIIELMRRAVASPTLEHKIPALHAMGHWEAKDLHGVSRENLRSRCNGQLVDCHPRLPLTADLLNSVKSSLGIPEFLNFTAWKPEIAELFDANGDMMQDSTRFFPQLLKDGIRILHRVGMLDLNCAWPGVLSALKRVPTPYQDEFINAADIPWPGEETEATFRVIGQGAGEFTYVQLHNAGHFVGADAPRMELKLAQHWIYNKAFDQTDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APZ1</accession>
    <name>A0A1Y2APZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_322277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APZ1"/>
    <dbReference type="InParanoid" id="A0A1Y2APZ1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="216" mass="22927" checksum="326B42AE6A27BA9B" modified="2017-08-30" version="1">MSTKPREPIVIRGFNPQPPTSSTSPSSSTSASATTSASSKHHHHHHHHHPPANLTFSPTFSTSPSGPTFSSSNSPSGPSTSTSSPTSTPSSTCTSRSNSTSSSSSKSSATSTSTCGSSAALEKDTSSVRRQRKQKQKPTFFVVCETETSDVVSSNTTPASSAVSSLQVRQVGDVRGVRDVRQVRDVRPVRDARDMRDMRDDHLDQGQHIEFAGQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQQ7</accession>
    <name>A0A1Y2AQQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_545747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQQ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2AQQ7"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="299" mass="31954" checksum="083DD154A922C7A0" modified="2017-08-30" version="1">MKVFLTGASGRLGTHIIPHLVARGHTVTGLVRSQASANVIKALGSSTAITPLVGSLEDTDLLISNAKSHDAVIHCAMDHKSGGDIGAKQEQATIKLFGDALEGSGKALLMSSGTGLVPKGSDETARSTPGQMLRPDTEVITLGLKDKNIRSIVVRLAMNTHDIANIHIFEGMLLGAAAEDKLGYIPYIGDNVWSACHADDAGLLYVLAMEKAEPGTVVHAVAEFVKVKDIAEALAKRTGFKTGEASKDKDKFASLGWLGMLLQWDNEVKTQWTKETFGWEPKGQGLLEEFTDAPDSYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQW8</accession>
    <name>A0A1Y2AQW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_581139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQW8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQW8"/>
    <dbReference type="InParanoid" id="A0A1Y2AQW8"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000105">
        <property type="entry name" value="Similar to LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="594"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="760" mass="80644" checksum="82B9326E167BCFDA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQZ6</accession>
    <name>A0A1Y2AQZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_453367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQZ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AQZ6"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="259"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="442" mass="49707" checksum="41D8FA239AB41C33" modified="2017-08-30" version="1" fragment="single">FLASLARDGDFETITTMVIRMVVIVAVIAGSRKASLWLYETTLRALFPTAYIAVSDPSYLWVMAWMAQDPSAQKQITDFQLSTEEWRQVRKSSASALRRSAETNKGGTVQNSSPSVGEQNASWAEGDIIGQIIPTYRYSIRLRHEGKYLWVKRRMSSFARSRLRTVDHIQIRTLFWQKDVLKRFLVAAHQSYFAKEDRELLIFNANRIVAKWQSPVSRPVRPWSSVILPDNMKEDLITDIGKFLSDKEVQWYAARGIPHRRGYLFHGTPGSGKTTLATAIASKLRLDIYVVNPSQRGMDDAKLSKLFRDCPARSVILIEDIDCIFPRNRGRNNVTLDGSDGEPTSSTTEGFDDIPNEPPVTPMFGGKHDLAPSTVTLSGLLNAIDGVSSQEGCILIASTNHPERLDPALSRAGRFDVHLAFFHASRAQARALFLHFYPLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR47</accession>
    <name>A0A1Y2AR47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_472124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR47"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR47"/>
    <dbReference type="InParanoid" id="A0A1Y2AR47"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF94">
        <property type="entry name" value="MDG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="444" mass="45538" checksum="C182F28CCAE1F0D7" modified="2017-08-30" version="1">MSAHLAKFTWGAGPQSVHVAGNFNNWSGDATPLNKLADGSFAADIPLPWGEKQAFKYVVDGDWKVREDEAKEWDAAGNMNNVYTAPHAPTSNEAESTTTAAAETTTTDVPPTSAPDVAPTTEPSTLLASSAPPAASRGEIPTLGAVSGATAAVPISAAPKTTEPTPVQIEKIAANANIGEAPTSQEQTYTEKATEIGAGLVGTLGAALGGAVAAVERATGVDITNTQPLSVEEATAKGIDVDTLEKKEGETDTVSPAGTKPSAEAVADLETKVQELKVDGEQQKDAASVSVNAPEPLPPKDEKLPNDLPAQDETTENHKTVPIPVITAVSEKDPKKDRTIANGDTTATKPVSSDPAVSAVDAKKEAETTASMPEAVTAVPITPVAPATPSKSTATPVSTTSTPASTPAKSAHTKDSSGGSDIKKKKSGFFSKVRSAFLLLPHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR66</accession>
    <name>A0A1Y2AR66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_471893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR66"/>
    <dbReference type="InParanoid" id="A0A1Y2AR66"/>
    <dbReference type="OrthoDB" id="3259746at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="151" mass="15655" checksum="358F5683D2411EAF" modified="2017-08-30" version="1">MIALVAISSTNASVVLAKRSEAGGILAGAPVSNITVYIDTLAECGWTTISWTGAVAPVSLMIGLGGYYVGTTTLETHDDLNDPEYGWTVSQPSGEDMIFQITDANGQIGYIQNQQVTAGDGWCLSSSSSSSVVASTSTGTDSVGKSYLYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASM0</accession>
    <name>A0A1Y2ASM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_507055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASM0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASM0"/>
    <dbReference type="InParanoid" id="A0A1Y2ASM0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="172" mass="19303" checksum="23090B1A67D0996C" modified="2017-08-30" version="1">MSSVHALLATKTDPSLVLRPGATEGGFPLTGDHDASPFHFIQSGSTRTLMPTFTSLQQERQYRKEHLVLVFRASHRAGLAEGIAGSYGHTHISDDFQVIVLPETPFNPTPSRSIRKQSPLLVCAFPTCTEWTRMEMWLKVPSPWIRVQLAFTRLYTKQGEEDPVIQEGQTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AST3</accession>
    <name>A0A1Y2AST3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein beta subunit GPB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_560951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AST3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AST3"/>
    <dbReference type="InParanoid" id="A0A1Y2AST3"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="345" mass="37262" checksum="BA8A153A8D4781F5" modified="2017-08-30" version="1">MSQAEIQEKISAARREADGLKDKIRAAKEQTADTSLRAMSNDVPPLPRMTMKPRRTLKGHLAKIYALHWAADKRHIVSASQDGKLIVWDAYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYSLRGAGPGGGQAKVARELSAHSGYLSCCRFINDRQIVTSSGDMTCMLWDIEQGVRTMEFNDHTGDVMSISLAPNANLFVSGACDATAKVWDIRTGKAVQTFTGHESDINAVQFFPNGDAFATGSDDASCKLFDLRADRELNTYAHDNILCGITSVAFSISGRVLFAGYDDYNVNVWDTLKGSVSECCPATIIGSAVWACQATGSHSAPEAGIVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATE0</accession>
    <name>A0A1Y2ATE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_590166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATE0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATE0"/>
    <dbReference type="InParanoid" id="A0A1Y2ATE0"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32517" checksum="0D19EC59D9E4EE14" modified="2017-08-30" version="1">MSFLKTRPSVQTIPATSPIEEILRILHRDGAIVLSDYCTDEEVDALNAKANVHFERTEKEGRGEDSFFKNFRASHTTAAYDLIGAAPEERKVWHQGKVFVHESADPTSVMEEFLCHEVWDWLGEERVTRKTGYWLHTSIAYKVGPGAGEQVLHRDINSAAIQRTGPESLTNGVSTFVAGCNVTAENGGTHVAPGSLAIWLSNIFHGAGANTLDPSHPDALRIIYGFFACGDNFRQGEITALACKPEEFQKMPPEILRLLGFYRGKSGGGALAGRDPIDSWEGLKGYRGGEWLVNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATF2</accession>
    <name>A0A1Y2ATF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_542949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATF2"/>
    <dbReference type="InParanoid" id="A0A1Y2ATF2"/>
    <dbReference type="OrthoDB" id="3032718at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="619" mass="68040" checksum="63688FC8930FF7BC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU45</accession>
    <name>A0A1Y2AU45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_542464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU45"/>
    <dbReference type="InParanoid" id="A0A1Y2AU45"/>
    <dbReference type="OrthoDB" id="2594518at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="26128" checksum="19FE7955AC7344AA" modified="2017-08-30" version="1">MSATFKDKAGNEYKLHQKFVDGNFTIISYDKVAFKLDDFYLKAHSPVFRSMLVTCDDKQEAVLHLEYYATFIAYFVTALKGLAIATLHCGNEREADAVFTLLKICSTYETPIICRVVLQSIRLDSKTSSKQLFPLFVVASQFNDLNLARRVIERCHYLELHRENGISLHPDSKRTRMKGSDIEKINSRWIWALYEASRLLEDRWDNWDEEYFMLFSGHFVALAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUS7</accession>
    <name>A0A1Y2AUS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maintenance of telomere capping protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_541552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUS7"/>
    <dbReference type="FunCoup" id="A0A1Y2AUS7">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUS7"/>
    <dbReference type="InParanoid" id="A0A1Y2AUS7"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="481" mass="51521" checksum="2EDD4733C89A5A6B" modified="2017-08-30" version="1">MPPKGKKTKAEEALDFLSNLDNLDAPPPAVPETSASPAPAIPTSSSTPRASTDSIRPLMKPATPAPAEEETAEAAKALAYLEAQINTKRAPLTRTASSVHPPPPPTATTTGGGSQGELPTNIPSQTQEEQSGGGWGSSWWSTATSAIQSAQKIADEGYKRVQAGGGVTGGLEQLGVKGVSVDLGKLRQGAGERLGGIVKGVDLEKLRQGLLNNASTTLATILDTVAPPISAHETLELWLSHPMIGYGGVEGVVYRAWTRILEQTESGEMVVVWSPDDDEADEDVARSIRPVEGWEEGWSFSQAALEAIRVREEKDPKGRGSANANLPVTTVPIFLHLQPLLAPLPFPEPQILLGAAHPAPENPPQHLFFLIHLQDPSHALRFTSITQPCPSDWLDVEYDRSDWVEERLVEVLRTGVEIVAQDYVATRMGLKPSTGMTRPASPDKKSQDDKQDQLENEEDSQVQAQDQDQVAVGAEAVKATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUV9</accession>
    <name>A0A1Y2AUV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_498885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUV9"/>
    <dbReference type="FunCoup" id="A0A1Y2AUV9">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUV9"/>
    <dbReference type="InParanoid" id="A0A1Y2AUV9"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="680" mass="75000" checksum="C0D479829FBC59F1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV79</accession>
    <name>A0A1Y2AV79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_542935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV79"/>
    <dbReference type="InParanoid" id="A0A1Y2AV79"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="80" mass="8874" checksum="44A84ABAAC8D38B3" modified="2017-08-30" version="1">MYNKLALVSVGYIVIVTHDMVYRFFPRFGPQNDVCLESSRWRLSGNTCSGNEGKPNTSFIGWWGGKDPSEDMGIIGSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVC7</accession>
    <name>A0A1Y2AVC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_540955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVC7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVC7"/>
    <dbReference type="InParanoid" id="A0A1Y2AVC7"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="437"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="756" mass="79317" checksum="D2EF7243463B8BC2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW57</accession>
    <name>A0A1Y2AW57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_255146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW57"/>
    <dbReference type="InParanoid" id="A0A1Y2AW57"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012621190" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="27121" checksum="CBCE2E4DF494E724" modified="2017-08-30" version="1">MHFTYFPIVAYLALSPIVSAGVCKHRQGKNSTSSASASASKQAPSSTSAISSAIFAASSASSATSSSASLAWDSSSAASSGSASSTGGDLLASPTSISSRSSATGNWTSSLITFNLTRTLPAASHTGSSDMWNCTESRASSSQSWSSTWTSQSADPTAPHTGGDLLASPTSISSNSSATSSRASSSKVSSRSSSSSERNTSTSKSATATSTASSGDVGSSTAWTELPKSLLLAVQQTFPLSLSLSLPCLAFPFFHDRYNQRLTPPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWF2</accession>
    <name>A0A1Y2AWF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_589446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWF2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWF2"/>
    <dbReference type="InParanoid" id="A0A1Y2AWF2"/>
    <dbReference type="OrthoDB" id="2564892at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="306"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="403" mass="42459" checksum="9C6CAC20558AA884" modified="2017-08-30" version="1">MESSEDVKDEESPSNLPPLKEGEALESTSNKPSVPLPKSLAAIDTINIPTHPSPPSAFTPTPTAVPVQSETQLHHPSPTKHHSSSPSLHSSRPAPASPAPSRPGSAILSPSLGPRPSSRDRSGSTSSSQGGSLRGGGRRGSTRPRSQLGSISHVPDLDSGGITPLGSELGDSLAVIPIPENSTLSTKSRDNTPGPSSRHSSSSNLIVIRDFAYSPTDERHRGRYPVNSPSITPHDTPDSGSTSPKKGWAGFGLLGWKSMLSGNTRQSTVSTSDSNFPETDPDHQQDDYEAFSDDDDDDDDDDDDDEPWGLYRAAYAFEPEGAHEIGLQEGDLVDVKGRGGGEGWVVASKRGVPGEGLVPEGYLEKVDSIDSIDDDDSERIQAIAASEHRGELVTTPGSLSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWJ1</accession>
    <name>A0A1Y2AWJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_540767</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWJ1"/>
    <dbReference type="InParanoid" id="A0A1Y2AWJ1"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="230"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY26607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="325" mass="35017" checksum="23AD87F67FDDB9E2" modified="2017-08-30" version="1">MGNNGTSGSNGSSAVSPAIDFTAGVIAGAAGLIVGQPFDVVKVRYQTPQFQGRYTSTFAAIGSIVKEEGTRGLFKGVMSPMAGIAFINGVVFTSYSFFMKLQHPSAYTSEPHLGQICLAGAGSGVLSAFITCPTELIKIRQQSAPPHLNLSTVSVCRSVIAADGLRGLYRGFSATALRDLAYGPYFCTYEAMCRLFKYLKPPPPPPPTPQALRHHHESLMEEADREVSELTWGELMAAGGVAGVTAWIATFPLDVFKTRMQSIPWPSTETQSPSRPSLWYTARHAIHNEGWRVMFAGLGPTLIRAVPVNMVVFVTFEACVMGMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWM5</accession>
    <name>A0A1Y2AWM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative phospholipase A-2-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_541277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWM5"/>
    <dbReference type="FunCoup" id="A0A1Y2AWM5">
        <property type="interactions" value="983"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWM5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWM5"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="8">
        <location>
            <begin position="380"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="9">
        <location>
            <begin position="521"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="801" mass="85742" checksum="0B0BDD40DF151564" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYI6</accession>
    <name>A0A1Y2AYI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_594419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYI6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYI6"/>
    <dbReference type="InParanoid" id="A0A1Y2AYI6"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="519"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY27653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="619" mass="71053" checksum="278315862F9004AD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYY6</accession>
    <name>A0A1Y2AYY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative aromatic-L-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_537190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYY6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYY6"/>
    <dbReference type="InParanoid" id="A0A1Y2AYY6"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="515" mass="56866" checksum="3B02F576B2AAF269" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B156</accession>
    <name>A0A1Y2B156_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_534833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B156"/>
    <dbReference type="FunCoup" id="A0A1Y2B156">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B156"/>
    <dbReference type="InParanoid" id="A0A1Y2B156"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000005">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="295" mass="33350" checksum="DF28F00244AC8568" modified="2017-08-30" version="1">MGRSRSEEVNIHPGWPTLLLSSILHRIHALLTSVLLYLLSLGPLPHHVGFVMDGNRRYARGRGMQVAQGHSDGFQSLRRTLEVCLKLRIRAVSVYAFAIDNFSREEEEVGALMRLARVRLMELCGHGDLLQQYGIRVRFIGRIEMLPKDVREAVQEMEALTRNHRNGVLNVCCPYASRDEITTAVRDTVKAAYADTSDSELEDVPSENVFGNLESCRSIASIASRGDKGDSGKLDILVRTSNVKRLSDFMMWQASEDTQLHFVRTNWPEFGLTDMLPILLGWQQKIWLRTLGIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B181</accession>
    <name>A0A1Y2B181_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane proteins 14C-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_534177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B181"/>
    <dbReference type="FunCoup" id="A0A1Y2B181">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2B181"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="10790" checksum="26CCA36669305873" modified="2017-08-30" version="1">MSHKPIAGLSGMSLLSGIFAYTRFGSTPSLIASVGIASAMAVSSMRIKDGMSYGLEGAAASSAVLFVPVARRALRTRAPIPAVTAVLAAASTGYYIREWLDSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2H6</accession>
    <name>A0A1Y2B2H6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_533586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2H6"/>
    <dbReference type="FunCoup" id="A0A1Y2B2H6">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2H6"/>
    <dbReference type="InParanoid" id="A0A1Y2B2H6"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="77" mass="8613" checksum="003732B3B0C93AFB" modified="2017-08-30" version="1">MLLKIKTLTGKEVEIDVQPEWQVKKVKEQVEEKQGIPPDQQRLIFGGKAMADEKPLTFYNITAGAAIHLVLALRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2T0</accession>
    <name>A0A1Y2B2T0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_532705</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2T0"/>
    <dbReference type="FunCoup" id="A0A1Y2B2T0">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2T0"/>
    <dbReference type="InParanoid" id="A0A1Y2B2T0"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="67"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY29123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="375" mass="41144" checksum="7408E5725ED277BB" modified="2017-08-30" version="1">MAARASRNLLPLSRSLATVAEAPVVARPTFRDGDVRTNWRRSEIQKIFDAPLLDTIFRAANVHRMHHDPSRVQLCTLMNIKTGGCTEDCKYCSQSSSYKTSTKASRLVDIEPVLEAARTAKANGSTRFCMGAAWRDLAGKKSGFEKILKMVSEVRGMGMEVCTTLGMLSPDQARRLKEAGLSAYNHNLDTSREFYPEVITTRSYDERISTIEAVRAAGISVCSGGILGLGEQDEDRVGLIHEVSRLTEHPESFPVNTLVPIPGTPLEDNKPVGVHTVLRTVATARIVLPKTIIRLAAGRHTFSETEQAMAFMAGANAIFTGETMLTTPCSGWDEDKSMLGRWGLRGQRSFEDHEVDGHVPEVESAVQAKRQEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3N8</accession>
    <name>A0A1Y2B3N8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_532465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3N8"/>
    <dbReference type="InParanoid" id="A0A1Y2B3N8"/>
    <dbReference type="OrthoDB" id="2561307at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY29354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15562" checksum="30E9BD0D85DADD37" modified="2017-08-30" version="1">MSPITREYIENIFKPLENGDYKALFAVVQDDVHWTVVNPNIKSFDVAGVYDKAGFVKAIAPLNACFPSPLALTIQHILVDQGGHTAAVELRAQAIANNAMKFDNFYTWICEFDDSPQPKIKAVRAYLDSAHVKAIIDSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3T9</accession>
    <name>A0A1Y2B3T9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar ATP synthase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_495335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3T9"/>
    <dbReference type="FunCoup" id="A0A1Y2B3T9">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3T9"/>
    <dbReference type="InParanoid" id="A0A1Y2B3T9"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="227" mass="25559" checksum="9C7047A234B1255F" modified="2017-08-30" version="1">MSRGGALDDSEIQSEMNKMVAFISQEAREKAREIQVKADEEFAIEKAKIVRQESFAIDAQYEKKRKQAEVGWKISQSTALNASRITVLRERNDQLEALFEEATKQVKEHASGEEYAKALENLILEVLLKLLSSNITLTHRPKDTDAVKKSADAALKRYKDMTGRDTTIDYDASLSDDSAGGVVGSSMAGRIKVDNTLSERLKILEEKMLPELRHDLFGANENRKFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B497</accession>
    <name>A0A1Y2B497_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 3 N-terminal helical repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_532078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B497"/>
    <dbReference type="STRING" id="71784.A0A1Y2B497"/>
    <dbReference type="InParanoid" id="A0A1Y2B497"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="3">
        <location>
            <begin position="93"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="494" mass="53717" checksum="5E26F021753DC527" modified="2017-08-30" version="1">MSRSNTHPEFPSLPAGSRERPPPDNGADLIHLINDANTLEAVRDYLISALQRISEGENQVGDDPQQKIKSGEALLASLGAAGLVPDQQQMIGKTAALVYIISARLMAPRITPESHNEAALQYAMTLCQIGEESQLELCRGRVALLAEGVLRLAKHLRRVDLIIEPLYRLALRAFPRGCFSGAHWVVLEACLLVRQYEPAKRIMLEIFTDLRYASPTYLDVLTFYHHAGLICAALKEYARAAEFFSVAVCTPTAAASAIQYACVKRAILCELIASGKPLVFPAYISGNITRNIERHAPDYLALAKAYEAADWAAVLNARSTKAFSDDNNLGLVDQVIASIPRRRLIKATNIYSKLTLSELATKIGLTGEDGTSRAGQLFAELCAAGDVHGEVTGDPPVVTFYEESGDPGPKHLVEQIETANLMASWLESHLDLSSKRLAGSKYYLRKQATAMQVSGGKGKGKAGGLWDTDAAEEADSEKTRRMRGPGGNYSDMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4T8</accession>
    <name>A0A1Y2B4T8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_505532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4T8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4T8"/>
    <dbReference type="InParanoid" id="A0A1Y2B4T8"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="189"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="362" mass="40816" checksum="35DDF0F0F05805BA" modified="2017-08-30" version="1">MSASNPLAGLTPEQQAVAIEQGAKALFESDLGIYLGPWLLGFTFDFALFGVMCHQLVHWLSLTSNERPFTRILLAWSVTASAASSFFALALIFHLFVYHFGTYSNFLTMQLVGWYTILIPLVILPAQLFYIERAYRINKNKIWIPIVGVALALGSVAGGIGGKIVVVRFSFAQLSGVRPYFWVWFGFTFACDSFLTGMILFGLWRSRTGWSQTDWLLNRLLRISVEAQLPATLLALALMITYSVKPDSFVLVFWEMWHPKTYVCALIAVLNAKFSLRADFASGGDDFSNSDKNAQNVYLHSERLHQDTVDIRDPDRSTESYEMPTLRIPLNRQQPPLTSDTQSDIVRGGEREWDSDNVRENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6B8</accession>
    <name>A0A1Y2B6B8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6B8"/>
    <dbReference type="InParanoid" id="A0A1Y2B6B8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="387" mass="42478" checksum="BC584D390C319906" modified="2017-08-30" version="1">MSSGMQPLPSYNAVRIGDQSAPVQSRRTKERQPPNAILRWPQQTAQGAQQAFQLTGQPPMNQVHSSPSNHHQGMTLPSTMSTGTLVSPGSSHYLTASKPGGNSFDAAFHGYQPSEPSQQDSWGWVDNQNSVPQRPGVSLPVSQSISMGITQSSPPRGQLPRSEMSMGDLIPQPHNGIESAIESGSFQPSSQQSQSMSMAIRPSESRVNSTRIIAIPQYQPPTGVIIGSSLSQSRKKRKRTIEESNSVPGGKDTHQASDASTRKRTRRDTRKPDSSSMPYNNTRSVLTKQEAIKDVAQLFRRVLTYDENMSLNSHPDQVSVGQRCPECTRLGQECLVKVRRLMGLTTKIASGTYSPAKDRTRLRCQKCTRSKQSCGKAFENNFVARVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8C5</accession>
    <name>A0A1Y2B8C5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_494257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8C5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8C5"/>
    <dbReference type="InParanoid" id="A0A1Y2B8C5"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="6">
        <location>
            <begin position="150"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="5">
        <location>
            <begin position="316"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="7">
        <location>
            <begin position="423"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="8">
        <location>
            <begin position="771"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY31053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="879" mass="97834" checksum="86BEC4D3E973CADC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B975</accession>
    <name>A0A1Y2B975_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_526626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B975"/>
    <dbReference type="FunCoup" id="A0A1Y2B975">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B975"/>
    <dbReference type="InParanoid" id="A0A1Y2B975"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="69" mass="7729" checksum="74CDAFACFD6CCCB3" modified="2017-08-30" version="1">MEGATKTPVKLARVIKVLGRTGSRGGVTQVRVEFLDDTTRSIIRNVKGPVRQNDILALLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9C1</accession>
    <name>A0A1Y2B9C1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_526772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9C1"/>
    <dbReference type="FunCoup" id="A0A1Y2B9C1">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9C1"/>
    <dbReference type="InParanoid" id="A0A1Y2B9C1"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="133"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="385" mass="42244" checksum="B95CACB2D185B351" modified="2017-08-30" version="1">MSKPIRVSVLGAGMSLSVLHVPSILALPDKFVVHSVLERTDTGRARKACGEGIKVVPDLEGVISDPEVDLVVIATPNTSHYSYSKAALEAGKHVLIEKPITPTAEEAEELVALAKSKGLILSVYQNRRWDSDFLTVKELLTSQKLGELIEFKSQYDRYRPLPPDSPRRGWKETPGEGNDVIYNLGSHIIDQAFVLFGKPQKVFARTWDIRGIGLDESFEMDLYYPPSVKSSTAPLVVRLSASILSRQIKQLRFALHGTKGSYTKYGVDPQESFLKKLAAGEPKGEGYGSEPPELWGQLVEDVAGGDKGKIEGEKVTGQDGVEFVVSKYKSQAGDYPALYENLYEAISSGDSKKLAVKPEEAIEVIRIIQLGLKSAKEGKVLDVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9P9</accession>
    <name>A0A1Y2B9P9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_106521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9P9"/>
    <dbReference type="InParanoid" id="A0A1Y2B9P9"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="122" mass="12940" checksum="2FAB65A0202DC253" modified="2017-08-30" version="1">MGGGAAPGGDFDALLAAADNQGWRGLFKNRRALGLALFASLGGVLYGYNQGVFGQVQVMSEFVNRYQSTLNDSTTKGLLTSVLELGAFAGSLIAGPLADAYSRKVSCLLHSRRYPYSFTHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9R9</accession>
    <name>A0A1Y2B9R9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkaline-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_593614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9R9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9R9"/>
    <dbReference type="InParanoid" id="A0A1Y2B9R9"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047400">
        <property type="term" value="F:phosphonoacetate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.110">
        <property type="entry name" value="Domain 2, Phosphonoacetate Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012710">
        <property type="entry name" value="Phosphonoacetate_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023116">
        <property type="entry name" value="Phosphonoacetate_hydro_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02335">
        <property type="entry name" value="hydr_PhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY30825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="445" mass="48281" checksum="15D7E11E61894262" modified="2017-08-30" version="1">MTITLSPVPTIATELPDVSVPGLKSSVEDSRSFTLHERVYKLPASPTVVICVDGFDPEYLTQGMADGILPNLACIYTAGFCATAHAAMPTFTNPNNCSIISGAATGVHGISGNFYLDPKTGEEKLVLDDTLLQGSTILEQMSLRGVRVAAVTAKDKLRRIIQHGLNPATGDICFSSEYADRCTLRENGIDNVESYVGRTAPPQYSGDLSLFVLDAGIKLLAENRADLFYLTLSDFIQHKHAPGSKESNAFFAALDDKVGQLVRLGAVVGITGDHGMSDKSTIDGEPNVLYVQDELEARFGAGCARVVCPITDPFVRHHGALGSFVRIHLDPAFKSKRDEMIKFLESSDKVQVVLPGEEAAARWEMPLYIEGDIAVVSVKHAVLGSKASEHDLENLKGHRLRSHGGLSEQDIPIMSSSPLSKEAQAEVSERQWRNFDVFDLVLNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9T2</accession>
    <name>A0A1Y2B9T2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_465879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9T2"/>
    <dbReference type="FunCoup" id="A0A1Y2B9T2">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9T2"/>
    <dbReference type="InParanoid" id="A0A1Y2B9T2"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="216" mass="23621" checksum="D3F43CDEB9408598" modified="2017-08-30" version="1">MTLGERNNRIALLAKRQNRPSVQNKRKVDDGDESLSVDQAARVLRAIEISRPSSSYNLRIDTQPERAKNKKKKAHIAPLRGRVVLPVDFRPTADKILVFALPGSADFRIAQAAGVDYVGGAEMFQQLIDGEIEPDKVLSSTNMIGPVTSTLARFLGPKGLMPTARRGLVGEGEMLANIIREAKGGLDWRANDDGRIDMIIGRVNISINLLLLSDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAH3</accession>
    <name>A0A1Y2BAH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_525647</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAH3"/>
    <dbReference type="FunCoup" id="A0A1Y2BAH3">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAH3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAH3"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="192"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY31839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="513" mass="57910" checksum="ADA00FEAD34C9D98" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAT0</accession>
    <name>A0A1Y2BAT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aldehyde reductase i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_524618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAT0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAT0"/>
    <dbReference type="InParanoid" id="A0A1Y2BAT0"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000034">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="328" mass="36990" checksum="24391A3CBD3337DB" modified="2017-08-30" version="1">MATQSFKLNNGLTIPSIGLGTWQSPKGEVAKAVEAAIKVGYRHIDCAWGYQNEDEVGEGIKASGVPREELWLTSKLFEFHHKPEHVELALRDTLKKLDTPYLDLYLMHWNIAFTMDAPEGELPVHKHLVKTDDGKIKLDKELTDNFIVTWQAMEKLVEKGLVKSIGISNFNIHKTKQLLAAAKIKPVANQVELSIQCPQPELVAWLKKNDILPQAYSPLGGTDGQHLREHKDIVAIAQKHKVHGATVLLSWLLKRGICPLPKSVTPSRIEANFKTIDLSSEEFETLEKLAEGHPPKRVCDQSDSLEPYYDIYQENDPEYSDKVQFAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAZ3</accession>
    <name>A0A1Y2BAZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_524678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAZ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAZ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAZ3"/>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="3">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="248" mass="27276" checksum="1E6EBD095AF3A7AD" modified="2017-08-30" version="1">MRNPLPASYYYFFWLVEPALTLCGAIYAIFLPEKYASELLPPHYERVTTIMGNTVRGQIVIGGLGSCFLLLAMISLSLFPIIKHTLKDQPAAQAKLVKGLLIPLAIADLTHIFVTLIPMPMSLLETPQKWTTLVNGNVWITTVLFIVRVSYLLGIGRKKTASPSNTLAAIENDTKKVPHSNPSFEKDSKKVPPTSPSVEKDTKKAQPGIPAVEDVAHEAPSVNQTPVTPSKTPRRRTRVKEAAHIETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB30</accession>
    <name>A0A1Y2BB30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_558138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB30"/>
    <dbReference type="FunCoup" id="A0A1Y2BB30">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB30"/>
    <dbReference type="InParanoid" id="A0A1Y2BB30"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001070">
        <property type="entry name" value="Dynein intermediate chain, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="504"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="695" mass="75571" checksum="09E5644AD261BE32" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB71</accession>
    <name>A0A1Y2BB71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_524785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB71"/>
    <dbReference type="STRING" id="71784.A0A1Y2BB71"/>
    <dbReference type="InParanoid" id="A0A1Y2BB71"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="46"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY31956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="549" mass="59548" checksum="4A5C1CCEB16CB1B3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBK2</accession>
    <name>A0A1Y2BBK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_524295</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBK2"/>
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        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBK2"/>
    <dbReference type="InParanoid" id="A0A1Y2BBK2"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="347"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="621"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="857"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY32134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1226" mass="135927" checksum="4B7F0466867995F5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBY1</accession>
    <name>A0A1Y2BBY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_71841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBY1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBY1"/>
    <dbReference type="InParanoid" id="A0A1Y2BBY1"/>
    <dbReference type="OrthoDB" id="2563669at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="352" mass="36535" checksum="DA6F4F2878DD9A29" modified="2017-08-30" version="1">MTGYSLYRATTQFSHGMVQTLPSTVHGGTIMYANTRVPLSIDTTDTDFDFDLSKGIYGVSLDNGQAQYYAGFSADAQFQAVLYASSGLTEGDHTLRLSNENGQNIAQYPQYIYLDVDEIAVTGTLLNAASATSDSSIISSTETTMAVLQTSQVASTSTSTQPTSTISSTTPSSSSSSSSSSIFTSSSAPTSTSTSTLTSATSPSLIPTSSTLASSSTPTTALSTPPPPISSIIIHPNTLVPSFATNKSEDSTTMETTGTPNVSAPLTSPPKVSSGVVGTAVGADGTGSSSHKTTTIAVSVTVIIIAVAVMVTIGSLYYWRTRRKKLDRDEQAFRGNGGRGRGGVPKSRWSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC69</accession>
    <name>A0A1Y2BC69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial outer membrane translocase complex, subunit Tom20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_524245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC69"/>
    <dbReference type="FunCoup" id="A0A1Y2BC69">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BC69"/>
    <dbReference type="InParanoid" id="A0A1Y2BC69"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY32130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="207" mass="22108" checksum="97F79F70E1197982" modified="2017-08-30" version="1">MSARTASQVAVITAAAALTGLVGYAFYFDYQRRNNPDFRKGLKKQQKKLAAAAEARTKAEKERNSKALREALATVQAEIPPTSPEEQEAYFQEQVAEGEKLSVQGPEFMVPAATHFYRALRVYPQPVELLMIYQKVVPAPIFALLLELTSLTGGGMGGAPPPGASLADIDEGEITGSPNGATSATSGSGSGMGSGGEWERLSDEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCG6</accession>
    <name>A0A1Y2BCG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_42421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCG6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCG6"/>
    <dbReference type="InParanoid" id="A0A1Y2BCG6"/>
    <dbReference type="OrthoDB" id="2560219at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="178" mass="19371" checksum="28E00D3606A1C1BB" modified="2017-08-30" version="1">MNSFQAVSGMLDIKPTNQELDAAIYTGLQAKEDEDADDVKPPPTTLVSSLDPVASVAEDPPLTPQQEEVLQRILRGENFFFTGSAGTGKSVLLRAIVKAFKMRHFEARQAVEQQRNQIVQDYLAGKLDNLKAVDENKVEKWHLAITASTGMAAVNIGGCTLHSWAGIGLGQLPVTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCL5</accession>
    <name>A0A1Y2BCL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_450540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCL5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCL5"/>
    <dbReference type="InParanoid" id="A0A1Y2BCL5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000425">
        <property type="entry name" value="PLAG1 like zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY32582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="55" mass="6273" checksum="0AA410BF80D02BE4" modified="2017-08-30" version="1" fragment="single">KYSCSFCAKTFSRPSSLRIHTYSHTGERPFACREPGCGRSFSVQSNLKRHAKVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCN1</accession>
    <name>A0A1Y2BCN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_523016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCN1"/>
    <dbReference type="FunCoup" id="A0A1Y2BCN1">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCN1"/>
    <dbReference type="InParanoid" id="A0A1Y2BCN1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF24">
        <property type="entry name" value="LANOSTEROL 14-ALPHA DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="388" mass="43178" checksum="24B106EFDCE0C64C" modified="2017-08-30" version="1">MTVALGPKGNNLSLGGKVSQVSAEDAYTHLTTPVFGKGVVYDCPNDLLMQQKKFIKHGLTTEALSSYAPLMYKEATDFFEHELGLTPATPGPKKLEALKIMSELIILTAGRSLQGKEVRASLNARFASLYEDLDGGFTPLNFMFPNLPLPSYRRRDRAQKEMSDFYLDIIRKRREGETEPEHDMISVLSGCVYRDGTPLTDRDVSHMMIAILMAGQHTSSATSSWILLHLAHRPDVVEALYEEQKKLFGNQDGTFREVTYESTKQMTLMEAIIRETLRLHAPIHSIYRKVLSDIPVPASLSSPSESSAYVIPEGHFIVAAPGVSQMDPLIWPDAKTWNPYRWLDEKGVAASAKEQYSGATSEQVDYGFGQVSKGTESPYQPFGAGRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCR8</accession>
    <name>A0A1Y2BCR8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCR8"/>
    <dbReference type="InParanoid" id="A0A1Y2BCR8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="412" mass="44376" checksum="DA563C7BC3ED2736" modified="2017-08-30" version="1">MARTSDKSTAISHTGPNGSSHFAPPGSIGTVTSSRIVSPARQQVRETDTDRDTRVRRIHDFLLHDGNRRSVFGLINDLPGGSISKDRRGNPSLFGLSDEDPGDDALYSGIAYTRELQRKANSAITTLRSKPRHQESLRILSDALFDWQDGTSLKERSSLTTSETNLLDYLPDHTASRGGGSTGQSASAITSVRRIGDSVVNPNMRRNPSGPSLPASPKPNPRTPPIFSPQPSIPPITIRSHKPNPPIRYSTKQTLHTLGSSPSEPGMPSWPTTSRDPSMFRKSRAHSIRTPSRISPLSASSTSSASTTFNTSSIPTPRTPGTTFTTFTTPTTPITPITPTTPTTPTTPTTPTTPDTSNEVHLSPGTGIMGSVLGIFTRSLRDGDSSLGRMKGQIRSPRHSPKSSKSEDSRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE83</accession>
    <name>A0A1Y2BE83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE83"/>
    <dbReference type="InParanoid" id="A0A1Y2BE83"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="248" mass="27587" checksum="AC8C68CEE958A2A6" modified="2017-08-30" version="1">MSHTDYHPPRSGYQSTDDLTTGATTAQVMETAGESQDRLDDFTSGGFGTFSLGPLHNWIDHDKTPDETTRKRNSSNPNALSCRPTYTSKPTTASPLSSEVVNSQCQMGESSHANPSTDDNTREMSALQASEQVVKWLDTHLPQSSLYSYPDQVPETGWDEFRILLSEWRSAAQREQSSRGAIQIHRALRSRYWSSGDAPVSLMQAASLIESTVKEEEEEKRGRGRDRTVSLLQGLRSRFAQSTASLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEC0</accession>
    <name>A0A1Y2BEC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_557304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEC0"/>
    <dbReference type="FunCoup" id="A0A1Y2BEC0">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEC0"/>
    <dbReference type="InParanoid" id="A0A1Y2BEC0"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="132" mass="15175" checksum="9D5347B80205D81A" modified="2017-08-30" version="1">MAVGGALGYSLAPILKSRYAGIAKLLKPVANLYASAAGWRKMGLKYDDLIPEESDEVQRALSRLSPRESYDRVFRHRIAFQQSILHKPLPKDQWLPVSEDKRYLTQLIKNVEAEVKEREEWDSLIVERKKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEM5</accession>
    <name>A0A1Y2BEM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_448211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEM5"/>
    <dbReference type="FunCoup" id="A0A1Y2BEM5">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEM5"/>
    <dbReference type="InParanoid" id="A0A1Y2BEM5"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001585">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="194" mass="21770" checksum="DACC74EBC1241E70" modified="2017-08-30" version="1" fragment="single">TSLLPPNLLKLFAPRPLPPFLRPLSKDERIRGPDKLTGVGNLLQRIKEEAEDAELQQGLAERPETKSEANGNVVAQEAEAAEQKMDVDGDSPQDDPNATGDPYKTLFISRLAKEDLRREFEIYGAIERIVITRDRKGKSKSYAFIVFERERDMKAAYKDAEGIPIHHKRILVDVERGRTVKGWRPRKLGGGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEV0</accession>
    <name>A0A1Y2BEV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_519441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEV0"/>
    <dbReference type="InParanoid" id="A0A1Y2BEV0"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="528" mass="59661" checksum="A0796FC3E57988B8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEW7</accession>
    <name>A0A1Y2BEW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_477897</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEW7"/>
    <dbReference type="FunCoup" id="A0A1Y2BEW7">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEW7"/>
    <dbReference type="InParanoid" id="A0A1Y2BEW7"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY33379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="335" mass="35930" checksum="BE89E7DC7BFC1EB7" modified="2017-08-30" version="1">MATATQINPAKSVPVETQHEDMIHDAQLDYYGKRLATCSSDKTIRIVNVVNGEAKGEPVILKGHTAPVWQLAWAHPSFGSILASCSYDGRVFIWKEVGPGKGKGSGGELQDGWERIKEHTLHTASVNSIAWAPYDLGPILACASSDGKISVLSFQNDGSTDATIFPAHGTGANAVSWAPPVTSVDSTTLKTQGNATLVSQKRFVSAGSDNVVRIWAYDEDAKKWLEDEALSGHDDWVRDVAWAPNIGLPGMYIASASQDRTVLVHSRSSPSAAWSSVALLPNTPDSSDPHFPDAVWRVSWSLAGNILAVSCGDGKVSLWKENVGKGWECVSDFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF03</accession>
    <name>A0A1Y2BF03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein 9/12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_519384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF03"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF03"/>
    <dbReference type="InParanoid" id="A0A1Y2BF03"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2440">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="83" mass="8657" checksum="FC23292F32F3AF22" modified="2017-08-30" version="1">MSDTGRQSLGDKAEAAVKPDSQKTYLEQGKDMLAGKSDSAASSAQPDSQKSTTQSIGDSLSGNSNENSDSLMNKAKDTLGMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGY2</accession>
    <name>A0A1Y2BGY2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_586195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGY2"/>
    <dbReference type="InParanoid" id="A0A1Y2BGY2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="173" mass="18539" checksum="E24A12AD59BBC352" modified="2017-08-30" version="1">MTFQFTPLVVAAIATGSLAVLVLILAMISMIIRRTCLKDSQTPSRYRYPSESLLKYHTSPPISLSQRSLSSLETPTISSSSSAGWLKRLRGDEMVMVTYKEGLQALGGIDRPQPEPSSLPLPLRSLPGRTASGGGGNAGRGERREDGLQSTWLPSYYRSELSQGGGGKGVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHK9</accession>
    <name>A0A1Y2BHK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_477209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHK9"/>
    <dbReference type="InParanoid" id="A0A1Y2BHK9"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="114"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="370"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="457" mass="48646" checksum="69F59205D9CA8A00" modified="2017-08-30" version="1">MLILAVLLPGVVAQLSLPIIADTSFSLLSGELVVARQLVSWGIKLAPVSFNVQLDKRRSRRRDGLDLDDNGRGSLLHVFDQVEESAVGWGDDVASVGWGDDENVARGERGDTSWYTYVSLGSPPQSVPVLPDTGSSDLFVFGPSCTDCYLTNHTSFSPPSSTSFINGSFDWTIGYGDGTTAAGYAGTDMLSLGDVSIPVLIGVAGDVRGSSVAISTRSGIMGLGLDPLASMTKDKTNGATIFSRLVKSGKLDENVLSIRLDKGQQSQGKVYKEGMGEYTFGGIEEQYVVGGRAVLVWTSVSSVNFWGFAIDDISMGITSVLAADAKTPHRAIVDSGTSLILTSATAAITIHSHIPSSFQDSSSGIWYIPCSTSFPLTQNLFFTISGRRFGVPIEDLAWKVSDTYSNCCISGVQGGMEAFTILGDMFIKNHYVVLSYGSTGDQLEVGFGDRVDVQPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHQ7</accession>
    <name>A0A1Y2BHQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHQ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2BHQ7"/>
    <dbReference type="OrthoDB" id="2552978at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="331" mass="36806" checksum="ABC0AB445077AACC" modified="2017-08-30" version="1">MANPNPSSITNTNPSSTTNTNAIAVATNAIAGPSTRSSSPSPSSSSSGWTDLPSDQEEMFYASDEDERERLRGQRRREWVDKLREERVRDREREERDKGREEVQAAAAKDLEEPSPDILTLMHHTATSLLASPNPRILELRIMTHHASDPRFNFLRGRHPLAWARIKAQVKVEKAKKEDPERIKREQGKVAGLVGGYESDSEDEDEDEGEPKDSPPPLPDDSQDPDPEELDGKDPVVRKDGKESVSRIDSHGSVISLHGDGSVIQVDGKGSVIQVHGKGPVIRVDGHGSVDDIMSTPPMTADQEASEEKKRIRRLKAEEWKRKRAQVAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHT1</accession>
    <name>A0A1Y2BHT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Quinon protein alcohol dehydrogenase-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_462749</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHT1"/>
    <dbReference type="FunCoup" id="A0A1Y2BHT1">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHT1"/>
    <dbReference type="InParanoid" id="A0A1Y2BHT1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY34349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="412" mass="44346" checksum="7A138562A10CC0D7" modified="2017-08-30" version="1">MTRTSHHPHPTPAFPVYALDWADDETLILAGGGGASRSGIENKIKLAKVNKDGRAVKYTAETKFSAEEDAPMTLAVDREGKRLVTGVNASSSSIKQGRNEHVRVFEYTADSLTPQRTAGTIRTEWSDDYPYQKLTVLSPSRTLVAVGTTDNRVSLLGVPELEEAVPTFGLDSELVDLDWGADNLVSLAVTTVSSLFLYKVSTGEKTTIELVQTIYSPSLDITSAAFRSARFSPLGTTSPIIHAVLNATKSPKRGAPRKAWVCTFGLVAGPSSTIRTAAEEGKGKEKETEEEPEKTEELGRWDVIVRREVSGKPVTVFDVSTDGRLLAYGSSDLSLGILDAKTLAPLLKILHAHNFPPTALKFNPSANMLVSASADNTIRAVVVPASFEGMSASMIALLIAILVILLALILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIF0</accession>
    <name>A0A1Y2BIF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_513415</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIF0"/>
    <dbReference type="InParanoid" id="A0A1Y2BIF0"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY34568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="539" mass="58934" checksum="EAC6C926C19C06EA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJG0</accession>
    <name>A0A1Y2BJG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurochondrin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_585851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJG0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJG0"/>
    <dbReference type="InParanoid" id="A0A1Y2BJG0"/>
    <dbReference type="OrthoDB" id="2570790at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="59833" checksum="6D653AC98D9D1571" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJG7</accession>
    <name>A0A1Y2BJG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_515582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJG7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJG7"/>
    <dbReference type="InParanoid" id="A0A1Y2BJG7"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="364" mass="39903" checksum="FEC9BF9197D84DF1" modified="2017-08-30" version="1">MLIGFLAALGCHICCFLYPAYASYKALSYHPETSPEAMQQVERWLMYWAVVGTWTAVEAVVGWTFTWLPFYNLIKTAVFLYLSLPQSEGSSYIYQRHLAPLFEEHEADIDAFLASLRGRATTALAGGVGWAWEKAKQQLNITIPDQTEPQTQGQGYQVHNEFPTTSSQPPTLQDPASGAVRQLYGFAARYAGRYLPIAVSTLQAAAASATARQQAQPTSFRAEQVAESMSMPIPIPTPSPRTTPAQSLRSRTYIHAQAQQQQSLGVSSGHMTTAAVPPVHSRAVSTPSAQSSSESLSSTDGREQRRSFGEMSYEQINRDEVGEMPVAGHSTPAASQGNRPGMEKRRSSWFGWAGTSTPEREKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKJ6</accession>
    <name>A0A1Y2BKJ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_508716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKJ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKJ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BKJ6"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="535"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="581" mass="63476" checksum="F2566AD45E8A6DCD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL58</accession>
    <name>A0A1Y2BL58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_510085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL58"/>
    <dbReference type="InParanoid" id="A0A1Y2BL58"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20054" checksum="4D3AEBC0973FE2A1" modified="2017-08-30" version="1">MAAAETTTAPIATKENGSAPAPTAEKSEEIQKVEKNGTGKEVEGKDEVEGKKEPEVGEKRKAEEVSEPEEKKAKIEDKGKGKGKSTATEEEEEEAQFDLGNESDDSGPIVSGPRVRNRVDYSSAKARAAAGLNEDDEGDDDDDDDDDEVNSDDLGDEDEEGEEDEGGNVDEQGGGEEDDEDDEDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL91</accession>
    <name>A0A1Y2BL91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">VPS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_567933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BL91">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL91"/>
    <dbReference type="InParanoid" id="A0A1Y2BL91"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000007">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012305157" description="VPS10 domain-containing protein" evidence="10">
        <location>
            <begin position="35"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1380"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="11">
        <location>
            <begin position="59"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="11">
        <location>
            <begin position="739"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY35539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1483" mass="165338" checksum="BCD4701DD457E905" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLA1</accession>
    <name>A0A1Y2BLA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TOM core complex subunit Tom6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLA1"/>
    <dbReference type="InParanoid" id="A0A1Y2BLA1"/>
    <dbReference type="OrthoDB" id="5514856at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7469" checksum="6C50BB894EB9B3B8" modified="2017-08-30" version="1">MSAPQQLTPAYLGSSKTPQSSNPLTAFWRSQVIAPEHRADNLVILRAVTVFAVGVAFVRSGLSSALVPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLG4</accession>
    <name>A0A1Y2BLG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_563149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLG4"/>
    <dbReference type="FunCoup" id="A0A1Y2BLG4">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLG4"/>
    <dbReference type="InParanoid" id="A0A1Y2BLG4"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="226" mass="25505" checksum="24CB761D017BD4FC" modified="2017-08-30" version="1">MSKLQASSVRSSVKTLLAQSGEETWKEAGGKKRNFVETIELQIGLKNYDPQRDKRFSGTVRLPHVPRPRMQLCILADAADVDRAKQLDEELPFMTVEDLKKLNKNKKLVKKLAQKYDAFLASEALIKQIPRLLGPGLSKAGKFPTPVSHSEDLARKVNEVKSTIKFQLKKVLCLGVAIGHCNMEEDQIVQNAMLSINFLISLLKKQWQNINSLHIKTTMGKPQRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLH6</accession>
    <name>A0A1Y2BLH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_511189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLH6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLH6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLH6"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="168" mass="18085" checksum="865F4E0A4C95A216" modified="2017-08-30" version="1">MSDIQSNLKQSNAAYAASFDQGHLALPPAKKYLVLTCMDARIDPAAALGITLGDAHVIRNAGASAVDALRSIVISQQLLGTHEIVLIKHTGCGMLTFTNEDARGLVEKNLGKEARAELGDLDFLPFPELDSAVKKDIAFIKQSKLVPDDVIISGWVYEVETGKVRQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMC5</accession>
    <name>A0A1Y2BMC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMC5"/>
    <dbReference type="InParanoid" id="A0A1Y2BMC5"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45336" checksum="DF001191F4711323" modified="2017-08-30" version="1">MLVDNRLSVRPTLKIVLAVLISATILLHLSSTSSSSSLYRHLPLKILDATIAKTVDLDWITKQYEYHLSLIRQKTWNVDRDHNVLFLNGLDEGREAYIDRLETFVGDYFPPKQQENLIAMLNRLKSGISPPLPAGRELPKTVFTNDKESIPDVFKGWMETHQDWEFQINNDDGMDDFITKYMGGSRFQHVFNRLPRPIFKSDIIRYLYLLLHGGIYTDSDTAPVAHALTWGHDPIPMLSPVLSALQSLMISGYDRLSSALPPLGERTGAILHPGISTIVSLEYNAIQDDRDKTIWEQDQLGWKRIFPRATQVVQYTMMSKPWHPIYLDVLYHTIMSSEDLEEQTEAGKMGIHDWPGALNLTGPGPFTDAVFRYLQVQYGYNPRDAPAINAKAQVIGDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMC6</accession>
    <name>A0A1Y2BMC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase family 18 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_513030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMC6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMC6"/>
    <dbReference type="InParanoid" id="A0A1Y2BMC6"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="1">
        <location>
            <begin position="291"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="576" mass="64619" checksum="59C701A3357099F1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMP5</accession>
    <name>A0A1Y2BMP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_509722</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMP5"/>
    <dbReference type="FunCoup" id="A0A1Y2BMP5">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BMP5"/>
    <dbReference type="InParanoid" id="A0A1Y2BMP5"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="161" mass="18454" checksum="039FBE97A2B55266" modified="2017-08-30" version="1">MLNYVMLVSRQGKVRLAKWFQTLPPKTKAKIVKDVTQLVLARRTRMCNFLEYKDTKVIYRRYASLFFITSVTPGDNELVTLEVIHRYVEVLDRYFGNVCELDLIFNFQKAYAILDELIIAGELQESSKKAVLRIVAQSDAIEEAETQEDSLSRLGSLAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMU5</accession>
    <name>A0A1Y2BMU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_513034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMU5"/>
    <dbReference type="InParanoid" id="A0A1Y2BMU5"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="8">
        <location>
            <begin position="302"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="494" mass="56343" checksum="A86820D1D044ACE4" modified="2017-08-30" version="1">MPLARNISRTLVSCSCIAAFLYFFTALSEYLNLHDLVPSGLSEPSTTYTLRSRDESTRVFRQDLKTTKFLSHAPGFSVVENLYWRNYTYYILTDQPWETPHLRYFASLSFDTQKTEGTLGILAAEIWAIRGDPIAPNVLDKDPQFGTSISFDEAVKKFGKAIELESPMLINDDDNFVNHMYHWIGETFIGAWRIWSSYAWRTGLVLPDFKTVAFIRQWHCAEKPEGHGAGDCWEDYPGANKWFTQKFFPGIKIESRTDWEARADTLQIYRLPLVVIADRAGGHNGPFSAWKPWGDVFRLPVMHDWLTQLRDRVLAGYTGRVNLRPKDTGRLRVMYLERQEHGRSLRDEDHDRLVEALEQLHKERVVDVVIETFTSAIPFADQVAKISTIDILIGVHGNGLTHTIWMNPGNDKAVFEMQPAACTITDYSPLAVAAGVQHYMVHETTFCHPVDCPQRGCTDHENYPDGINSDDIRVTPSVITNEIRKIAQRAAAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADK6</accession>
    <name>A0A1Y2ADK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_555145</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="MCFC01000130">
        <property type="protein sequence ID" value="ORY20601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADK6"/>
    <dbReference type="FunCoup" id="A0A1Y2ADK6">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ADK6"/>
    <dbReference type="InParanoid" id="A0A1Y2ADK6"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="15">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="13">
        <location>
            <begin position="340"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="14">
        <location>
            <begin position="635"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY20601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="975" mass="107735" checksum="3672EF7B4F767F70" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEY2</accession>
    <name>A0A1Y2AEY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_474635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000117">
        <property type="protein sequence ID" value="ORY21153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEY2"/>
    <dbReference type="InParanoid" id="A0A1Y2AEY2"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="2">
        <location>
            <begin position="76"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="484" mass="53137" checksum="F142008F8877FEAB" modified="2017-08-30" version="1">MTISTPRRSVTWRPDRAIHRFSTYRHLHRLLIPFLAIWATGFILLIRQQYYIPTPEYIGCTASPWDNWPPDVCGINATDCATDLVTASYRCPGACRDVTLGNPRWVGGEQVNGVPFVVGGNSDTYRADSWICPAAIHANMISPRFGGCVTVDAIPFLQGASGFLNSTSNGITSSSFLPHFPGAFTLTSHSQTGCIDLHAYISTYNALCLAIFTLFLQPSTGVLYSVLMVLGYAQIKLVSNPPTMMPDWSAIAGDLPAVLGAVYWIWHVAFKRTLKGFKHLPLETTLWQGLGYWIGVESSTIFAKLPISRLGYDPLDPAGVITLTIIVVLVVIVVVVQVWDMRKYGTVWYYLIRYLPLVPIVILLATLPGYYFRPHHYLLSLLALPVLSLPNRVSLFLQAFFLGLFLDGVGRWGWDSIIETKAALLGDADAGTGTPTFDLVNSTASLLSWDGGSDVGDSTGSGVGVMIDDVLREWDLMTNSESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFD6</accession>
    <name>A0A1Y2AFD6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_555009</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000128">
        <property type="protein sequence ID" value="ORY20675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFD6"/>
    <dbReference type="FunCoup" id="A0A1Y2AFD6">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFD6"/>
    <dbReference type="InParanoid" id="A0A1Y2AFD6"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY20675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="208" mass="23042" checksum="3A28B67435311AF5" modified="2017-08-30" version="1">MAGPHYDFLIKLLLIGDSGVGKSCLLLRFCDDSWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDEKSFNNIRTWHSNIEQHASAGVNKILIGNKCDWDEKRAVSLEQGKQLADEFGLRFLETSAKANEGVEEAFFTLARDIKTRLIDSQPEAAAAPSLAADRRGVDVNKQGSSSSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHB2</accession>
    <name>A0A1Y2AHB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_552674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000102">
        <property type="protein sequence ID" value="ORY21906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHB2"/>
    <dbReference type="FunCoup" id="A0A1Y2AHB2">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AHB2"/>
    <dbReference type="InParanoid" id="A0A1Y2AHB2"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="73"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="469" mass="52777" checksum="5A4498F2FFE2B9F3" modified="2017-08-30" version="1">MPRPRSLVIRIQSLLSRSTTPTRHFSTTSITRSSSGIMATRKALIPQSQRMFDGNTDKQDVWSIFTPANVPPDAINLGQGFMNWGPPKWVLDEAYQTISTDIMTNHYPHPRGRPRLIKAISKHYSPQFENLVKEGRELKWEEIVVTAGANGGMYAALTAHLEPGDEVIFLEPYFDQYFATVHFQGAKPVFVPLHPPTGEGVKGGGEWTLNIDEFRAAFTPKTKAFIINTPHNPVGKVFTRKELEEIAKVCVEKDILVLADEVYDCMVYDGKEHVRIATLPGMWERTLTVGSGGKSFACTGWRVGWLIGPPELTLATQAAHARIVFCTNAPMQESVAIAFEGAAKHNFFAEQLAAYQERRDVLCSYFDQLGLSYTKPEGSYFLLVDMSPIKVPEEFVEKVPDSIKKGRGKDFVLCWWLAQEIKVVAIPPSEFYCGEHVEIGERFARFAFCKNPELLHDAGKRLLRLKDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHW7</accession>
    <name>A0A1Y2AHW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_391227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHW7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHW7"/>
    <dbReference type="InParanoid" id="A0A1Y2AHW7"/>
    <dbReference type="OrthoDB" id="2595589at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="427" mass="48398" checksum="28DC7B643247C9A8" modified="2017-08-30" version="1">MSNENDTTTPEDAGCGIDSHAESSRTHISRASKACENCRIRRIKCEPPYPCKACRLAKLTGCHVRPKARPGRQSRQQDPSKILKGTGYRERTSGLERLDKELEAIFEERTGGPIDLKVVEEHTHPLLDLSSPLPTLPSLDSSASAAIRQFTIYCLPYCSFLTPTRISHLFDRYEAAPLSLSPDQRALVYVCLACGYIRLQYFGEGGRLAKFVPEEERLDVVWYRQAVDALDKWGSATFTSLHALFCMWFYTTLVCKSDATRFVCSWMISQARELGLHQEQTALAVPYSPSDRADLMFVMILYAHYYSVALCGHPPMIKPGEFDTVIFHSSDLQVDDPSSAIVPRRAVVELLLLNTQAHLNLHDEVASNLSIDWLLRIEHNWTAWRRSWIKHGRPVWDPYTGILWDWSVSRLSFSFFLTAVISTHGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIM9</accession>
    <name>A0A1Y2AIM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">STE like transcription factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_551591</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIM9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AIM9"/>
    <dbReference type="InParanoid" id="A0A1Y2AIM9"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="661"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY22438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="687" mass="75505" checksum="B29B78DBF8D71443" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL93</accession>
    <name>A0A1Y2AL93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_549642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL93"/>
    <dbReference type="InParanoid" id="A0A1Y2AL93"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY23272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="75" mass="8814" checksum="843B258ECBC75238" modified="2017-08-30" version="1" fragment="single">MENREWRMENGEWRMEENGEWKMEEQGAASHLRGMRRVSVKSTSFGKLSTWLVGYGMKRVSSEVFGNCVKLNVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL94</accession>
    <name>A0A1Y2AL94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_550166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AL94"/>
    <dbReference type="InParanoid" id="A0A1Y2AL94"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF28">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1102"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="890"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1353"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="962"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1365"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1412" mass="151200" checksum="BE00ED31E6FD422E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALK2</accession>
    <name>A0A1Y2ALK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_507851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALK2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALK2"/>
    <dbReference type="InParanoid" id="A0A1Y2ALK2"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012869809" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="6">
        <location>
            <begin position="480"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="668" mass="70775" checksum="F2AE597BD88DA154" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALT2</accession>
    <name>A0A1Y2ALT2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_500907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALT2"/>
    <dbReference type="FunCoup" id="A0A1Y2ALT2">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALT2"/>
    <dbReference type="InParanoid" id="A0A1Y2ALT2"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY23442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="118" mass="13256" checksum="DD0B09CB2923ED93" modified="2017-08-30" version="1">MDYKDDLDKTGAATAKVHKIRITLTSRNVKPLEKFCADLINRAKDKDLKVKGPVRLPTKVLKHTTRKTPCGEGSKTWDRYEMRIHKRLIDLNSSADVVKQITSISLEPGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALW2</accession>
    <name>A0A1Y2ALW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_566903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALW2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALW2"/>
    <dbReference type="InParanoid" id="A0A1Y2ALW2"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="42663" checksum="1FEBEE9A890269F9" modified="2017-08-30" version="1">MSDLTRLPTLTVQSHRTPFSFFTPTHLSFAPRSHSHSQSPSSTSSSSSTKDTSQNVTWQSRKARKGRYLPKTTHVHSAAHAQGAGAGGEEKAQGGKREVAARLKHPGSRLKPGFTVDISFWVAVSFTFGSMVWVVNGFVVWFPILRPSLDTTAFTNTSSATAFIGGTVFLVGSYLMVVEALDRYVFSTLGRESQFGTALGELLHYHRNHPSGSSTSVNKEQSPERDDSIGHEVKVVLGASGWVWWGKPLWHDMGYLAAVVQLFAATIFWISTLTGLPGVIKGFSTGDGSKAIIDVFFWTPQVIGGSGFIVSSLILMVEVQKKWYIPALSDIGWHIGFWNLVGAIGFTLCGALGYSSSSGAVYESALSTWWGSWAFLIGSGIQCAETVWREPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM11</accession>
    <name>A0A1Y2AM11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_549079</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM11"/>
    <dbReference type="FunCoup" id="A0A1Y2AM11">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AM11"/>
    <dbReference type="InParanoid" id="A0A1Y2AM11"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="17">
        <location>
            <begin position="34"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY23536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="537" mass="59101" checksum="8C8C2D2D7A7FB93F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN47</accession>
    <name>A0A1Y2AN47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_548078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY23993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN47"/>
    <dbReference type="STRING" id="71784.A0A1Y2AN47"/>
    <dbReference type="InParanoid" id="A0A1Y2AN47"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY23993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="397" mass="44462" checksum="429DC520BC2D5606" modified="2017-08-30" version="1">MPPLLTEEETAIDPYTTLGLTSNATEQEVKKAFRRLSLKYHPDKDSSEKAQVKFRAISVAVEILSDSSKRAFIDRKVEVDRARKEKYELSDKKRKDLIDALRDREEAAKKAKVDEVKRRQQASAEEAVVEHTKKMLAEAQKRATAATSASRHSTQPKAQPTTPTSNGHSHADARPHISEEDLALLLTIPSSSSFTSSSQLKTTLESRYGRITRVDLRDPPEGEKKKKRKRRAVVDFAEGNWGGCWACMKDHAEGSVSGGREVEDGIKAMWLAGKEPAWVKWAEMQAENINVGNGNAHEPQSQPQNGKTTMADLLARHRKDQGGVQVEQRKEDVESTVLFKLRQMKRAKADAASVSSVPNEVESGGPRSDSQRELERRRLEEQIRREEEAEEMQGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AND8</accession>
    <name>A0A1Y2AND8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_548578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AND8"/>
    <dbReference type="FunCoup" id="A0A1Y2AND8">
        <property type="interactions" value="632"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AND8"/>
    <dbReference type="InParanoid" id="A0A1Y2AND8"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012643775" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="400"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY23810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="508" mass="56338" checksum="F0F5DEE7D6ED95F4" modified="2017-08-30" version="1">MRLSPLSLLLVIPFVLAEPRTLQQITSDANRLLAEGAYLEASRSYSEAIDLDPNSYVNYYKRATAYLSLGKNNAALDDFDTILKLNPSFSQAHLQKAKILAKEGDFDTAKTELKLFGKTKESEEASELVNSITAASAEKKSALAALKSNHWDRCVEHATKALEVGINSIEIREVRLKCEEELGDVDAVYGDLSRLASLNPSALSLPLRLSHIAYFLLASPTATNHIKQCLHYDPDSAPCKRVHKLLRSLDKDTAKARNFVEGSSWRQAIKVLDGEDGLLARFDAALAQAIKEEYLPLQFEPKKRSLKRLELYALACKAAVGANDLSSSKGGKWCQETIWMDPENMDALVGQGEKLLKEEKYEEALRMFENAFEKSGRSSQDIMNRVQKAQKLLKISKQKDYYKVLGVPRDADERQIKKAFRTAAKNAHPDVGGSEEKMAALNEAYEVLSNPELRARYDSGDDPNDPHQGNGGGQNPFAHHNGGGMPFQFFQQGFPGGGGGQKMHFQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANK0</accession>
    <name>A0A1Y2ANK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_337669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANK0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANK0"/>
    <dbReference type="InParanoid" id="A0A1Y2ANK0"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="696" mass="77712" checksum="417E9B88DC5E2676" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APA3</accession>
    <name>A0A1Y2APA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_547741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APA3"/>
    <dbReference type="InParanoid" id="A0A1Y2APA3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012124085" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7796" checksum="5514C25B20E87768" modified="2017-08-30" version="1">MARRPTPIFKVLYVLFICSSCRTVDTVDTVDTVVHTVVYTVDTVDTLASALTVRLSGESEKHRATPHVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APZ5</accession>
    <name>A0A1Y2APZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APZ5"/>
    <dbReference type="InParanoid" id="A0A1Y2APZ5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="173" mass="18305" checksum="4B11354BAF29D0DA" modified="2017-08-30" version="1">MSSMLSLVPDPIRTFRSLGSGLSSLRSLSSLFGWPFTKSLGTSTGATDETFESSTVKGSTVNTRQSSVPSWSDVQSTVFPELTTLPGSFPLSPSEKSSDPSGPVTEDLRTTGASGFGRSTDNNDLTNNGSTIIDHPSTDLQPKASLDQDRTNGYSACSSPLSPQLKLEISRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ07</accession>
    <name>A0A1Y2AQ07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_319392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ07"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ07"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="210"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="438" mass="46595" checksum="ECFC5CC21E71E21B" modified="2017-08-30" version="1">MRTDNIIVPIPVGNEPCCAACGNTIPTGTTALRRDKTFNPEARETIKTSIEAASADLKEISLFLHANPELKWEEFKAHEKITTFLTKEGFKVESIEGMPTAFRAAFTQGTGGRTFGLNSEYDALAEIGHGCGHNLIAISGIAALLGLRAAMQKHNIPGTVVLLGTPAEEGGVGKQLLLDKGAYSDMDACMMLHPGPGPSPKGHIGPSLASIGVQIEYFGKAAHAAMAPWAGVSALEAAILAHNSIAALRQQMRPEVRVHGVITQGGGYASNIIPAYAELTYSVRGISTAALEETWVGVKKCFENAALTTGCTVKINRGLVHDDLRNSKPMCEEYAATMEEMFGIPVTYGFDQAASWGASTDFGNVSYVLPGCHPMIGMPTPPGCVNHTVDFTTIVGQDEAHVQTFKASTAMACVGLRFLADTAYAKQVAQYFKEDMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQX7</accession>
    <name>A0A1Y2AQX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_471882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQX7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQX7"/>
    <dbReference type="InParanoid" id="A0A1Y2AQX7"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="1">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="155" mass="18334" checksum="92F49E5DAA02A0AD" modified="2017-08-30" version="1">MADSYRSQEEWVSKRRLVQFWRRQEGTAIFATCRPLPQHDYPQQQNSIIISCIFREEKNTCYVTSVDAIYLLEALVGNRFTVEEKNRIRRNLEGFRPLTVSKSRPESEEFFKLIMGFPNPKPRNIEKDVKVFPWDILGQALKKIISKYVSIYVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS11</accession>
    <name>A0A1Y2AS11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_290881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS11"/>
    <dbReference type="STRING" id="71784.A0A1Y2AS11"/>
    <dbReference type="InParanoid" id="A0A1Y2AS11"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="697" mass="76851" checksum="1D631FDA5D87FAEF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASX0</accession>
    <name>A0A1Y2ASX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_544018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASX0"/>
    <dbReference type="InParanoid" id="A0A1Y2ASX0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013186395" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32956" checksum="6F57212A64DB5608" modified="2017-08-30" version="1">MRSPIFFLTILCLFLISQEGLAKRSQGKAASDPRYFKQTTRSDIVLRQQNRERLKAIRADASKRKELTARQATASCSPHPTCGTDYQPTVNSYALFPLLDLWHDDIENSVESDLQTCAASGQALGSVGAVTYIPHGASDSNAGKCYRKGTELSSGTWRNKTTTSTLLFGSCCDYNGIVPSDVLSSCCQTRSCNPTSYPTCNSTFNAGSGYAVFPNWDPYYGDLGDCSIETSRAACSSRCDDSNTCAGYYFSNGSGCNCYLKTGSASDFTWEMYHDTVSTGVFYGSCCDFAGVAPDNVMASCCQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATA8</accession>
    <name>A0A1Y2ATA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_543098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATA8"/>
    <dbReference type="FunCoup" id="A0A1Y2ATA8">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATA8"/>
    <dbReference type="InParanoid" id="A0A1Y2ATA8"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="175" mass="18832" checksum="90596082907BA615" modified="2017-08-30" version="1">MSFARRFASTVSEMSQVYFDVAINNAPAGRITFKLYDDVVPKTAANFRALCTGEKGFGYAGSGFHRVIPSFMLQGGDFTNHNGTGGKSIYGNKFPDENFKLKHDRPYLLSMANAGPNTNGSQFFITTVVTSWLDGKHVVFGEVTQGSDLVKKIEGLGSDSGKPKAKVSITSSGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATS9</accession>
    <name>A0A1Y2ATS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Quinon protein alcohol dehydrogenase-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_544385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATS9"/>
    <dbReference type="FunCoup" id="A0A1Y2ATS9">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATS9"/>
    <dbReference type="InParanoid" id="A0A1Y2ATS9"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000464">
        <property type="entry name" value="Ribosome assembly protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="526" mass="57384" checksum="CD3C96D2BF288D82" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATW3</accession>
    <name>A0A1Y2ATW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_542273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATW3"/>
    <dbReference type="InParanoid" id="A0A1Y2ATW3"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="521" mass="58742" checksum="8F23E77C7CABCE3B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUT0</accession>
    <name>A0A1Y2AUT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sister chromatid cohesion protein Dcc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_542734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUT0"/>
    <dbReference type="FunCoup" id="A0A1Y2AUT0">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUT0"/>
    <dbReference type="InParanoid" id="A0A1Y2AUT0"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="402" mass="44973" checksum="2E894C98B7805A8C" modified="2017-08-30" version="1">MPIATTLPSSSIVLRYPTTSTSTPEVIQEESYQLLELPAEILKAVEKSSEPFPLTIKGRPNDDAVLCTPSTTFLLRTVTISNSLLILRPPPPRPATATRTDPTLEIRDTCHQVLECVPQAASLERIRTVLRESAWEGTGTLGKRKRGDKEPRRYTREMLGSVIQGSEVELERGLKERNVIPYRGRMMLLPLNHLHPLLSLVLALLTIHHTTIALNESPPTAVSPSRPLQEALDQDHEIDPEITRGVMGLFGEMDSDGEVWTCRPAEMVREIGKGLLGAVKSSGMGLDKLLNDWKEAVGETWSDLVNVNLLEGDHLLVDPPPAVTSQPRLIVPFPLYQLPLNPATRFADLFLTRPKWRPDDMIPFLKGLYRDGDSKERDKLVAKFVRVVKEGQGAWWYPRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVE3</accession>
    <name>A0A1Y2AVE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_541678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVE3"/>
    <dbReference type="FunCoup" id="A0A1Y2AVE3">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVE3"/>
    <dbReference type="InParanoid" id="A0A1Y2AVE3"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="113"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY26260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="404" mass="44228" checksum="44C5F85EF9CD5C27" modified="2017-08-30" version="1">MPAPLPGRFDEDPRVHFDKTAGNYQYEDEETGKEYEWNGKVWIELVDEEQWRAQQAAYSIAGVDESTPANAVVAREERRNKKRKKGEAGPSYKASSISASTSAPQPPSAPKRTAVFVSNLPPTTTAAQLASVFSKAGVLMLGDDGEPRIKLYHDDAGNFKGEALVMFFKEGSVDLAITLLDDTELELGTGWGNIRVKEAEYGSGQGQGQGQAEEKKNGDAAEADGAKKAEKKKLTAEEKQRISKRIKTMQNKVTWHSDDDSDDPAAPIDGAPAPGANRMNRVVVLKGMFSVEDVEKDPGLLLELKEDVREEAETLGTVTSVQLYDQEEDGVMTIKFKDAVSAQACVMKMNGRFFDGRQIFAGIYSGKERYRKSGGGGLGDDDEEEQDRLEGFASWLVDDDGEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW97</accession>
    <name>A0A1Y2AW97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_541040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW97"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW97"/>
    <dbReference type="InParanoid" id="A0A1Y2AW97"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="445" mass="47159" checksum="E70D33038233AF9D" modified="2017-08-30" version="1">MESDPWADTPSSPKQPEVVEVAANGPSTSTEATPTVEQVAIPVGTSSVEETSDHVDLNLIAGSDLTGDVSQETAGVEAGAAEDGGDEFEDFDDFDASAGGPGPSTSRTGEDGEDGFGDFGDFEQGDFTTSEEAVNGDGDMLSNGNGGIVEEPDVYEERFQSLHLDPMPSRAELLDQLTNLLAPLLPSPSDPSLTDEPQRAVGGLSQIMISESSREAYAQLTTAPMLKPLDWTRSRVRRDHLISMGVPVNLDEVDSHRLSTLPPLQINVNPPTPRRADPNARYSSIQKGKGREIPLNSGRNSMPASIGSGLAGRGLVNGDPSKVHGLGARPEIDIAKAEELCGIEEEQLTIMSLNRLKRLQEQLVSMTADASSLLGYLLQLKDAQTQDSDTYNGMISELIANAAKVKSAQSAAASGGVFRRASTRRPNSMSGTNTPRRVGTPTGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWC0</accession>
    <name>A0A1Y2AWC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWC0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWC0"/>
    <dbReference type="InParanoid" id="A0A1Y2AWC0"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="57" mass="6432" checksum="756C69894E7DE8C5" modified="2017-08-30" version="1">MAAFHPPTAPLLHRFLAKSLGAGMWFFIFYRARQDGAVLLGLRHPWDGHGDHGSEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXD4</accession>
    <name>A0A1Y2AXD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_539316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXD4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXD4"/>
    <dbReference type="InParanoid" id="A0A1Y2AXD4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="560" mass="62309" checksum="C5C18188E0E966D9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYC7</accession>
    <name>A0A1Y2AYC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_539956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYC7"/>
    <dbReference type="InParanoid" id="A0A1Y2AYC7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="918" mass="103292" checksum="A0169A10187241B0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYX3</accession>
    <name>A0A1Y2AYX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_565619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYX3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYX3"/>
    <dbReference type="InParanoid" id="A0A1Y2AYX3"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="172" mass="19121" checksum="FA270F80BBEC96DD" modified="2017-08-30" version="1">MGSSIAYPDIKELFDRNREWSKQVHASDRDVRCLRIRLIPQSFSHYPGQRPKILWIGCSQPGDIFTHLNIGEAIMLIALQNCPVVHIVITGHTNCVGCQQDLNVASLPPMPPSYALQPGQDMFTADSPPGLDNLLASDAVLNDWKRRGDAGVVVHGWVYHLENASVQRASRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ04</accession>
    <name>A0A1Y2AZ04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative rRNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_226786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ04"/>
    <dbReference type="FunCoup" id="A0A1Y2AZ04">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ04"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ04"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="25"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="484" mass="53798" checksum="3799FAF6A012F2A6" modified="2017-08-30" version="1">MGQRRRKNRTHLKGPAKGETEENVPKSFVIKSGQVTKSISQLVRDTRQLMEPNTASRLRERPHARLRDYLTMAPSLHVTHLLAFTLTDAANVHLRVARLPQGPTLTFRVQRYSLMKDLVNASLRNIGKTPGGEFRNPPLLVLNNFQQPAEGPQLPQLRLMSTMFQGLFPAISVEKSALPTFRRVLLLSYNHTTHLISLRHYSISVRPHGVSRRVRRLLNPSTGSVKTSRKTPNLATTDDIADYLLRRPGTPGSEVGTAGYDSMSETDASEAESDTNAVELPEDYVGRGNKKGERKAVRLVETGPRMELKLIKVVEGLVGSKKGEGETVFHEFVHKSKAESTALNKSHQERKRAKDARRAEQAANVARKKAEKASKKGEKGEDDEGGEEEDDDDIDVDGLSDVDPEEALERRRTRLSQADDGDADEEEFQYEDAAGLQDGEREDDGDWDEDVDAGDVSSGEEQSGESSEDDEPAPPPKRRNAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZY4</accession>
    <name>A0A1Y2AZY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M24, structural domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_537282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZY4"/>
    <dbReference type="FunCoup" id="A0A1Y2AZY4">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZY4"/>
    <dbReference type="InParanoid" id="A0A1Y2AZY4"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="36"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="398" mass="43066" checksum="0110243CE651E818" modified="2017-08-30" version="1">MSTEPSVDLKKPVEPVDSTADKQEEKGLSGDAITKYTTAGQALADVLKKLIPQITAGKSVLDLCVEGDKIINETVSPLWNKAKNGVKISKGIAFPTTISVNNVVSHFSPLPSDPEILLKDKDVVKIMLGVQIDGYAVTHAETVQLTTKAEGVAADVIKGAFEAAQAAMRTLKIGAKNWDVTDVVEKVAKDYGCSSVEGMLSCQHERNVTDGKKRILLNPSPELKRDHETCTFEEGEVYGVDVLLVTGSDGKAKPDASRTSIYKKADINYQLKMKTSRAVFSEIQKKAGAFPFTLRALDDEKRARMGVQEAVAHGLLKPYDIVQTASGTLVAEFFFTLALLPAGPLLLSPVPSWYSADKVSTEKGIQDEALKTLITQPLRAPKKKKAKTNGESREEPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0J8</accession>
    <name>A0A1Y2B0J8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAM signaling pathway protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_535150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0J8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0J8"/>
    <dbReference type="InParanoid" id="A0A1Y2B0J8"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="348"/>
            <end position="465"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="769"/>
            <end position="796"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="815"/>
            <end position="839"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="860"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="918"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1034"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="1136"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1244"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <end position="407"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <end position="447"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1004"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1148"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1179"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1263" mass="135374" checksum="3F40EADE4A17B34F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0R8</accession>
    <name>A0A1Y2B0R8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_576628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0R8"/>
    <dbReference type="FunCoup" id="A0A1Y2B0R8">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0R8"/>
    <dbReference type="InParanoid" id="A0A1Y2B0R8"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="174"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY28326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="619" mass="65968" checksum="22751066C1AC1E5F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0V4</accession>
    <name>A0A1Y2B0V4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pectin lyase fold/virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_534726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0V4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0V4"/>
    <dbReference type="InParanoid" id="A0A1Y2B0V4"/>
    <dbReference type="OrthoDB" id="2587928at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011965714" evidence="3">
        <location>
            <begin position="19"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="4">
        <location>
            <begin position="176"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="615" mass="66529" checksum="7053CE9AEBD0A551" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0X1</accession>
    <name>A0A1Y2B0X1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_202078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0X1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0X1"/>
    <dbReference type="InParanoid" id="A0A1Y2B0X1"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="450" mass="49597" checksum="F272EE15665DC7E5" modified="2017-08-30" version="1">MLHAWASAEPTDAERQHTVNLLEQLSVALNARLGGPRPSLEKGYRRFEVDIFGSVSWGGETGQSGDLDLVVIDKDERQGYRPDLWKVPPTRHFSKDDQSGYGKLPPVYNLRSVARVLWSIGMVDCLPIVHASTPIIKFKDASNGQECDLNVNDLGGWYNSSLILHYCMISPFVLRPLIHALKIWASTHNLNDSAGARGPATMSSYCLALMAIAYLQHCGVLPNLQQDVRVPIPHVAKDTKDPDAVWVGWGKDQGIKALVGFERNPPYGWTPRNLTAADALRGFFEYFSTKSGSPRFDYQSQVVSILNGCIISRAEPQGAATRAESDRRKELLGKGVSEKAITSILSEARANAARRELSMGKGNIGIQPLKWGESKLVVQDPFLWSKNCAGGMTKIGVGRFQETINRTYELLRTLGSDTTIHDILNGVVSTDSPIPKSRSRNKSRSTRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B144</accession>
    <name>A0A1Y2B144_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_594202</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B144"/>
    <dbReference type="STRING" id="71784.A0A1Y2B144"/>
    <dbReference type="InParanoid" id="A0A1Y2B144"/>
    <dbReference type="OrthoDB" id="6600518at2759"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY28280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="644" mass="72886" checksum="741D556673192486" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B187</accession>
    <name>A0A1Y2B187_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cell polarity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_534959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B187"/>
    <dbReference type="FunCoup" id="A0A1Y2B187">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B187"/>
    <dbReference type="InParanoid" id="A0A1Y2B187"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="64"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="788" mass="87638" checksum="3B9BC760276A1D21" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B195</accession>
    <name>A0A1Y2B195_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multiple drug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_534346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B195"/>
    <dbReference type="STRING" id="71784.A0A1Y2B195"/>
    <dbReference type="InParanoid" id="A0A1Y2B195"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="102"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="692" mass="74858" checksum="72BADE084828AA74" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1A8</accession>
    <name>A0A1Y2B1A8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_536481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1A8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1A8"/>
    <dbReference type="InParanoid" id="A0A1Y2B1A8"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="335"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="619" mass="67425" checksum="FBB8C1F0D9188AE6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1B7</accession>
    <name>A0A1Y2B1B7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_468094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1B7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1B7"/>
    <dbReference type="InParanoid" id="A0A1Y2B1B7"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="63788" checksum="0B95312614E61B8C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2F2</accession>
    <name>A0A1Y2B2F2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_575404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2F2"/>
    <dbReference type="InParanoid" id="A0A1Y2B2F2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="318" mass="36079" checksum="060919F610A0AC36" modified="2017-08-30" version="1">MDSPRYNRWSTPDSDSDITEHPSTRETDGFSPTHLPTPISTPQPHTPDRSIIVTSSDGFGLKSVHSGDKGGPQKKKRDSEGGGEDGRYPDKLAVVERLRTDVGDLAWDLTGVVVDPETMSTYDWRIRSRRWIFSLEASLPSSLQEELRKVTTYLKPREQDKIAPIAPGTPLGILERELSAYIGLLDDITTPLARLGVYDLFERYEAEDSLQEILRFTLGVRQSWTDIQLEVGMDELGKDREEVVRKLECQWSLFQSEFMKVVKDRLIKAERLDKRCPSMMSRMARENKILKKQVDGAMEGHQAHIEDAMLGLSMARTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2G4</accession>
    <name>A0A1Y2B2G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_535240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2G4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2G4"/>
    <dbReference type="InParanoid" id="A0A1Y2B2G4"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="80"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="184" mass="20341" checksum="7B4A1859BB651754" modified="2017-08-30" version="1">MAEEARESSPRIDDDVNVDEELQLMQARLAQMEEEKNQLAASEKAQLKAGSTSGTPKPEGDGDGDEATMEEDQPEAVDARSVYIGNVDYAATPEEIQAHFQACGTINRVTILCDKFTGHPKGYAYVEFAEPSIVQNALVLNESMFRGRLLQVKEKRTNIPGLNMTNRGRGRGRGRGRPFRARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2K7</accession>
    <name>A0A1Y2B2K7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_533360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2K7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2K7"/>
    <dbReference type="InParanoid" id="A0A1Y2B2K7"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="305" mass="32605" checksum="C4138316B154ED1C" modified="2017-08-30" version="1">MAALELGKSAFGTDALEIASLFDISGWVVVVTGGGTGIGLCTATALAANGAKVYISGRRLEPLQAAARDAKPRRGGGQIIPVQADISTKEGILKLKSEVEKEEKWINVLVNNAGVSLKGPNIEAADQTALGLSTAMFEEEEFEKWSEMHRINTAAPYFLTSALLPLLSAAQTVGNYPEPGNVVNVASLSGITRTSQRGQFSYNSSKAATRSLSEMLAYEFAHRGLGIRVNCINPGYFPSGMSPKDLETKQGPEKAEYLRTKHGIPFGRVGNARDYAQCILGLITNQYMTGTEVLLDGGWLLESAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3N3</accession>
    <name>A0A1Y2B3N3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_533100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3N3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3N3"/>
    <dbReference type="InParanoid" id="A0A1Y2B3N3"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="61"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="437" mass="47948" checksum="F50470F03F1F377B" modified="2017-08-30" version="1">MPDIDLIAAQEANHAGPSKGKPAKSAKAWNIRASPAVGRSRNPIRATLATLTTVKPTTTKSLINLGIGDPTHYPLHPPPPAATSSVRDAVISERANGYVPGAGMVSAREAVAEYHSRWDGVKYGIDDIVLTHGVGQALDLVFSILFPHQLAERSNILLPRPGFALYATLLANLNVEVRYYDCLEEQGWEVDLDMLESLCDDDTRAIMITNPSNPCGSNFTESHLRDILDIAEANRVPIIADEIYGHMTWTRPFIPLAALSTSVPILTLSGLSKRFLLPGWRFGWVALHDPLGVAAPIKEGLGVWANRFFGPCSLTQASLPDILQTESQWFDDVLAKVRANADVIYSAINETPGLSCSKPEGALYILVRIDQTAFPQFVDEVDFCTTLLREEAVFVMPGLCFETPGYFRVVIASPADIMHEVGERLKEFSSRHCRQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4L2</accession>
    <name>A0A1Y2B4L2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_533592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4L2"/>
    <dbReference type="FunCoup" id="A0A1Y2B4L2">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4L2"/>
    <dbReference type="InParanoid" id="A0A1Y2B4L2"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="544" mass="61738" checksum="2C02700F6D04E305" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B524</accession>
    <name>A0A1Y2B524_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 14">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_598649</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 14"/>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B524"/>
    <dbReference type="FunCoup" id="A0A1Y2B524">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B524"/>
    <dbReference type="InParanoid" id="A0A1Y2B524"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000006">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY29650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="515" mass="56325" checksum="1ED949EE6D34F340" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5A9</accession>
    <name>A0A1Y2B5A9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_530669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5A9"/>
    <dbReference type="InParanoid" id="A0A1Y2B5A9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="293" mass="31604" checksum="B0EDE279823537B0" modified="2017-08-30" version="1">MPPSRSSSNPGLPAVTIVLTPYPGHQNVSPRSPRPGTPYALTPYPHNTTFLSTSPGRSPLGSPAYLLNPAVEPIVSQRARSNHLDKPIRPIVTKSSHSHTKHVSIASPSLHSPSPSHHSASLNRQHSPRIVSSPYLRRTHLIPASLRMTSIRTSATESSPSPLPPTPMTRFPSHFSSVSPLNTSEKWVKELKKRPAPILIPTLQAGGSSSLWGRRHINSEMTEGEASSTPHDEEGQDTARGSNIARSISPDNGPTAIPLTVRRLGTGWLTAEVPLLRDEPSPGWADFQAISIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5G5</accession>
    <name>A0A1Y2B5G5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5G5"/>
    <dbReference type="InParanoid" id="A0A1Y2B5G5"/>
    <dbReference type="OrthoDB" id="2563704at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="532" mass="60679" checksum="20D07A9428D1444A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5Q5</accession>
    <name>A0A1Y2B5Q5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_574112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5Q5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5Q5"/>
    <dbReference type="InParanoid" id="A0A1Y2B5Q5"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY30171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="576" mass="63031" checksum="EF0DA7F2C4CFBE1E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5T1</accession>
    <name>A0A1Y2B5T1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_529941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5T1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5T1"/>
    <dbReference type="InParanoid" id="A0A1Y2B5T1"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="182"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="607"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY30199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="752" mass="82462" checksum="EAA922B47FA60484" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6A6</accession>
    <name>A0A1Y2B6A6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_530054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6A6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6A6"/>
    <dbReference type="InParanoid" id="A0A1Y2B6A6"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="343" mass="38690" checksum="DA2391054DBBCCBD" modified="2017-08-30" version="1">MPSPLITHIYTADPSAHSFNDRLYIYPSHDRETSIKFNDRGDQYDMVDYHVFSMDDIPSEGGSQVGVDGVEKRSQEVVDHGIALKVEDVSWVSKQLWAPDCARGKDGRWYLYFPARDKEGIFRIGVAVSSKPEGPFTPDPLPIPGSFSIDPASFVDTDGKSYLYFGGIWGGQLQCYSTPEGGIFDSTKDGPYEPSGPGVTALLPRVAQLSTDMHTFETPVRDIQIVDDDGKLLAADDHDRRFFEAAWMHKRNDIYYFSYSTGDTHLLVYATGNSPFGPFTFKGKILDPVLGWTTHHSIVQHRGKWYLFYHDCELSNGVDHLRSVKVREIWYDDKGDIVSQKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6A8</accession>
    <name>A0A1Y2B6A8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_165112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6A8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6A8"/>
    <dbReference type="InParanoid" id="A0A1Y2B6A8"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY29635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="525" mass="57121" checksum="E365B99F502B5A51" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6C4</accession>
    <name>A0A1Y2B6C4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_529562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6C4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6C4"/>
    <dbReference type="InParanoid" id="A0A1Y2B6C4"/>
    <dbReference type="OrthoDB" id="2563021at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011965715" evidence="3">
        <location>
            <begin position="21"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="617" mass="66827" checksum="A690F3DA426B7C46" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6S2</accession>
    <name>A0A1Y2B6S2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAC3/GANP/Nin1/mts3/eIF-3 p25 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_163185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6S2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6S2"/>
    <dbReference type="InParanoid" id="A0A1Y2B6S2"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45598" checksum="33DA888B868A634F" modified="2017-08-30" version="1">MSRPAETQRYQPPHLRGQSPRPETSTASSTKIPGNSKVRPIASNGPSKSTNVNGASLPRSRRDWSSPSTFISSSGNVSHGVLQSPAGDIKPMRRAHSGRTELDPMEMMQSVSRSGGDGAEGDALKDWGVQEQYRQWIDQRLDKHYETFSTPRHTSPATDRTDEIESLSSIVLLFRKLREGVVASHRIDAFAIEVFESSARISVLAGNKTQLVASLSGLIPGLYTAVSPPLSPDQPSSLDRALASLRISDARQELTSIYLLYRLVTDSPRAMHELLISLTLPSPPLLFRPFSSVETAAVRPSSHPFIHPSQLAYPLAAARALSEHSFDPVAYFRLLEDHSAGAYERIVLRWATDGVRERAWTRLKRTYLDVGVGWVGKCLGFTADEGKSEEDLHLKKWVQEHGAKSNAGRIKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6T4</accession>
    <name>A0A1Y2B6T4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_494484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6T4"/>
    <dbReference type="InParanoid" id="A0A1Y2B6T4"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="234" mass="25409" checksum="BF6AA83A5019CEDD" modified="2017-08-30" version="1">MATRISVLVAARMARPTAVTSVTAISRALTSHQTFNGLYSGLTRYRASQLRQYASTSSEPDSTSDPTLSRALELIDRGTEAFEKGELRAAKELYEESVGVRETSGAWFNLGVCEYHDGQHAKAITAWENSTRLNPSADAYTNLASAHIMSKPPQPALAIKHLTSALELAPDDPEIAFNLAAILESTDNFEPALNMYQRASKGGVERAEQNIRSISAKILARRAAQEKQAGQADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9N3</accession>
    <name>A0A1Y2B9N3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hscarg protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_480597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9N3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9N3"/>
    <dbReference type="InParanoid" id="A0A1Y2B9N3"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="317" mass="34626" checksum="3B9AFC996F30B282" modified="2017-08-30" version="1">MSKIVVILGATGKQGGSVINSILSDPTAKPHFSLRAITRDTSKPAAKALADRGVEMVAADLDHKDSLIKAFQGAYAVFAVTDYWNTLSKDVEIQQGKNIADAAKTTGVEHFIFSTLINATKATGGKLSGIEHFDSKATVTDYVISLGLPATFWLPGYYMSNLPGQGLRKDESTGKYVLSTPNKPESKFPLIDIVNDTGKFIKAILLDREGTLGKHILGASGYYSPQQIIDGFAKVFPKDGEGIKFVTVPDDAYKNALLSNGMPDRVAEEILQNMHLLNDDYGYYSKEPLEESIKIVKEPLVSWEEFLKNTPAFKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAD0</accession>
    <name>A0A1Y2BAD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_526655</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAD0"/>
    <dbReference type="FunCoup" id="A0A1Y2BAD0">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAD0"/>
    <dbReference type="InParanoid" id="A0A1Y2BAD0"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="200"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="344"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="228"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY31427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="404" mass="44104" checksum="50D6981C18D60146" modified="2017-08-30" version="1">MASTSAPETLQNPSSTSAGTSAETQPRQPIWLRCEKKPFEHRSALTPTTARVLLDNNFEVFVERDPQRIFDDAEFEEVGCKMVPNNEWPSAPLDVPIIGLKELPESTDPLPHTHIQFAHCYKHQGGWADVLRRFAQGKGTLYDLEFLEDPVTHRRVAAFGFHAGFAGAAAGALAYAAQQQSGGDGRLAALKPYDNEAAMVEHVRAGLAGVKGGIDEVKVLVIGALGRCGSGAVDLFRKAGLKEDNIVKWDMAETARGGPFQEILDVDIFVNCIYLSKPIPKFITSEFIAEAGDARRLSVVVDVSCDTTNPHNPIPIYDINTTFPDPTVDVDTKGVGKRCTVISIDHLPTLLPRESSEQFSKDLLPSLLQLPERASAPVWVNAEKLFKEKLAEAKAYDEENGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBM1</accession>
    <name>A0A1Y2BBM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_60626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBM1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBM1"/>
    <dbReference type="InParanoid" id="A0A1Y2BBM1"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="4">
        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="23252" checksum="15BCB7B9515DAEFD" modified="2017-08-30" version="1">MRPPTEEDQALWSSMLRFIPLDYALLPYLSKSGDSSLSSTSPSSVSSTSTSTSLGKTSSSCSSETSTNTKGHLVLLALDDIPPLNPNGVGRKGCEGWRMRFGVDVLPEWDNSSGVMHGAVASFLVDTCTSAALISLQTDNFWSPPMVGGVSLSLDVQYFHPALVGTSLIIDVEVNRLNTTLANLTCHIREEATGKVLAMGTHIKAWRPGPQRKNGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBU5</accession>
    <name>A0A1Y2BBU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_523859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBU5"/>
    <dbReference type="FunCoup" id="A0A1Y2BBU5">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBU5"/>
    <dbReference type="InParanoid" id="A0A1Y2BBU5"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="50"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="584" mass="63161" checksum="72BB5A77F68610DE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBW1</accession>
    <name>A0A1Y2BBW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_47169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBW1"/>
    <dbReference type="InParanoid" id="A0A1Y2BBW1"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="576" mass="61504" checksum="9DA05D05EBE632C3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC88</accession>
    <name>A0A1Y2BC88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mannosyltransferase putative-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_524143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC88"/>
    <dbReference type="STRING" id="71784.A0A1Y2BC88"/>
    <dbReference type="InParanoid" id="A0A1Y2BC88"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="638" mass="70948" checksum="0816A59BC4C67752" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCH3</accession>
    <name>A0A1Y2BCH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Splicing factor Prp8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_522644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BCH3">
        <property type="interactions" value="923"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCH3"/>
    <dbReference type="InParanoid" id="A0A1Y2BCH3"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prp8_domainIV_fingers"/>
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            <begin position="1842"/>
            <end position="1946"/>
        </location>
    </feature>
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            <begin position="1"/>
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            <begin position="46"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY32519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2853" mass="326464" checksum="6A5501888D850AB7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCQ2</accession>
    <name>A0A1Y2BCQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_465358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2BCQ2"/>
    <dbReference type="OrthoDB" id="2566675at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="126" mass="13623" checksum="EABC6924EC8E86EE" modified="2017-08-30" version="1">MAFTIHPLLSTYPGASFFPNGNLTGPHLAQASGGDSGGYWAYVPWDIPSIPPHHQWGLPPALIALREGRGTGVYGRQGPGLGRGVPINYGWPRYGPMPLKPELGGFVGKINPYGRSFPHGYYKTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDC5</accession>
    <name>A0A1Y2BDC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_521719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDC5"/>
    <dbReference type="InParanoid" id="A0A1Y2BDC5"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.30:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit eIF-4F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="794"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="632"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1067"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1177"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1120"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1216"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1398" mass="150080" checksum="4C274E67E271BCA3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDJ6</accession>
    <name>A0A1Y2BDJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_583338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDJ6"/>
    <dbReference type="FunCoup" id="A0A1Y2BDJ6">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDJ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BDJ6"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="30474" checksum="3C5291953C8AF7F9" modified="2017-08-30" version="1">MAARLRLANKVCIVTGAGGGIGLETTLQFAAEGALVLLSDVNDAALSKAVDLVAKNFPTSEAIGVKCDVSKESEVESLVKTAVSKWGRLDVMFNNAGIMHPSDGDAIETEDRIWDLTQAINVKGVWYGCKHAQNIADGHQNKADPEKGLSAGGSIINVASLVAIMGAATPQLAYTASKGAVLALTRELAMVHAREGIRFNSLCPGPIRTPMLMDFLNTDEKLNRRLVHSPMGRFGEPVEQAMAVVFLASDDSSFVNGTDFLVDGGLTACYVTAEGPSTTPPVGLTSKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDK4</accession>
    <name>A0A1Y2BDK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_557472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDK4"/>
    <dbReference type="FunCoup" id="A0A1Y2BDK4">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDK4"/>
    <dbReference type="InParanoid" id="A0A1Y2BDK4"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="309"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="625" mass="70031" checksum="E439D84A95857B30" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDN5</accession>
    <name>A0A1Y2BDN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBS and PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_522278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDN5"/>
    <dbReference type="FunCoup" id="A0A1Y2BDN5">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDN5"/>
    <dbReference type="InParanoid" id="A0A1Y2BDN5"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="78"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
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            <begin position="254"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="336"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="485"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY32884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="73552" checksum="43796585680381E4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDP3</accession>
    <name>A0A1Y2BDP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_522319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORY32894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2BDP3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="301" mass="33407" checksum="E509C06490704597" modified="2017-08-30" version="1">MTTCPRTHDSMFGFSRLRDESGLPLTKRRPPTPPKSITFGNWTDREAFVRKCTGTSDESKVEASLDTLDRLNGLCSIPLQGSNKGSISDTIFMTTSDGEHVCAIKTGRIMSRVQTYVVAMSVGCDGGSEMGHMVRDLELYYGETAASRLKEVVNGLMHELNTQVEETITQKKKDRSVWRSMRTGFRSWIVDGRGSQGSHSTKLYKSRVSNLRQFTEASTQFRKTFEADENNYQTIISLLDPTAQSQFTEATQSQKTFEADVKNYLPIISLLDTTANPIQPDDSNEDSSLNPSPGGSTTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDP5</accession>
    <name>A0A1Y2BDP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2586454at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="446" mass="49041" checksum="A79D860D86C6DBBB" modified="2017-08-30" version="1">MADTLYPNTNIPKESAWRSYSSSPADAPIRPTLALEVPSWGVVFMIPPEDALVHAQLSNAEPRYDHLLNGEFIIALPPGCGKLRCKSLKIGFRATSILDMGPGRMGEVDILFQREVKTAPPEGLVLEGTQRFDFSLILPSTLAPRDWHRNGRVANTLYAEVEGQPIAVGSHRVSPEPPVRTRSRSNSPPSLERLVLSASSLLSMVKKETVVPQPPAYDPTNESSDPTDHWLRGTHTAERIIRLIHNPDLSGGITVLNEQSNGDTPGLGHYEILLFSDIWTISTLLKATLALTDLPPETTVFNFKVTLCQNWTIRSPRDGPDGPEIASSRRFVLIEEGKRPQRPHMFPGPSHPALWRGTAAGGSDDGILIVESKNRIPGDSLLRPSTIPGLITPIRVSHAFEIDIFFSVFGTQPSGKTMRPSGPGELRVMRVRRPVVLPGVCLWYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEA4</accession>
    <name>A0A1Y2BEA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEA4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BEA4"/>
    <dbReference type="InParanoid" id="A0A1Y2BEA4"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1222" mass="133668" checksum="A766500214CAFD10" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEH6</accession>
    <name>A0A1Y2BEH6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_583294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEH6"/>
    <dbReference type="InParanoid" id="A0A1Y2BEH6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="405" mass="44963" checksum="9416532F7A685360" modified="2017-08-30" version="1">MAAPVPVQSRPIAALQALCPQAVRLQGVGSTREIKPDTNDDLTMRGWGTGSTEKPCRVQQEAYQRLEPMSLRVSCGELTGREALKRTFLFSCTVPRPYGLTGASYILARPKRRKILRKQIRIADPLLPLRVSDARVVGDGASKRRRPFSPSWGRLVTPTSAMDDHTGHLSVSQDASSSGQSPRLRFKRVIEDRYTIALLSSEQDRQSFRNEWTQGGREKNFSRKLLKSAGTGSQGETMVVGGSFDDLNTLYTLSQSSTGGYTCRAYSHLKTQSWCCIQTDEVVDEKFDNILGSQLDLSGVQNQNVKEKFRRVHRLFQEMQTFLDQTTSSSPSTVPQVQFATSPGISEYPPFSQPGRRYSNPSTRNRSTSANSNVSDGGGTSFRSNRLPPPPSPLRHEVSKVDLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFA4</accession>
    <name>A0A1Y2BFA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoplasmic reticulum-based factor for assembly of V-ATPase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_520390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFA4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFA4"/>
    <dbReference type="InParanoid" id="A0A1Y2BFA4"/>
    <dbReference type="OrthoDB" id="3193718at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26310" checksum="5D9C991D897F6E16" modified="2017-08-30" version="1">MTTIRVTLPPHLRERIRAVLEHVQLPHELQGLNAALNQVRVEPEETTIDEEVLTRLARWAETVEGKVTLKRSGLDPAEYGFIALFAGTQVYLPAKQVELLQDKPNSFLPGYLAPKAPTFGQEYRETARQLSTALNILFSIVGSAAAVYVASVTGAGYSRETAVVLAILAGVVVGIADGVLVWIVSDRANKARQEMDHLRLEASKGSGAVEEQERDEKVIQPQVKGEVRLRRRALPGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFB8</accession>
    <name>A0A1Y2BFB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_520667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFB8"/>
    <dbReference type="InParanoid" id="A0A1Y2BFB8"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="740"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1647"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2087"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2187"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2087"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2125"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2141"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2187"/>
            <end position="2198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2227" mass="246358" checksum="5EC18B63BEFC083F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFP5</accession>
    <name>A0A1Y2BFP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_519597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFP5"/>
    <dbReference type="InParanoid" id="A0A1Y2BFP5"/>
    <dbReference type="OrthoDB" id="2587036at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17877" checksum="CEA91FA1C2029438" modified="2017-08-30" version="1">MPAGTQAHGMLISPERVHRHLQATLADRNGPHTAVLTAPQGQILGSASVAPNSDSKDSYTDDPGHEMNDNEPWLETPERLRLLVGLASQWHTDESPRVECELGRLLMMPIALPDPEVPPQNAAVPVMRSRTPSSMLLVLNSTSSVSWSDLVVKAEAFSSVWRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG78</accession>
    <name>A0A1Y2BG78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_519336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG78"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG78"/>
    <dbReference type="InParanoid" id="A0A1Y2BG78"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="4">
        <location>
            <begin position="670"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="813" mass="91027" checksum="E4C78A6633B5C428" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGK6</accession>
    <name>A0A1Y2BGK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="10">ITPase</shortName>
            <shortName evidence="10">Inosine triphosphatase</shortName>
            <ecNumber evidence="10">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="10">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_556745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGK6"/>
    <dbReference type="FunCoup" id="A0A1Y2BGK6">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGK6"/>
    <dbReference type="InParanoid" id="A0A1Y2BGK6"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000009">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="191" mass="20291" checksum="F99D7E476070D20C" modified="2017-08-30" version="1">MTSFVFVTGNANKLKEVKAILAAGGSDIQVTSQAIDVPEVQGSTQEVAIAKCRAAAEKLGTACVTEDTALCFEALDGLPGPYIKDFMAKIGHDGLNTLLDGFPTRAATALCTFAYSPGPSHDPILFEGATQGTIVAARGPTHFGWDPIFQPDEGGGKTYAEMHGSEKNLISHRYRALEKLRVYLSEQATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGS0</accession>
    <name>A0A1Y2BGS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_518072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGS0"/>
    <dbReference type="FunCoup" id="A0A1Y2BGS0">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGS0"/>
    <dbReference type="InParanoid" id="A0A1Y2BGS0"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="24181" checksum="CB6AA670D370EFAC" modified="2017-08-30" version="1">MSKAQFLREYKLVVVGGGGVGKSALTIQFIQSHFVDEYDPTIEDSYRKQCIIDEEVALLDVLDTAGQEEYGAMREQYMRTGEGFLLVYSITSRSSFEEVSTFHQQILRVKDKDYFPVVVVANKCDLEYERQVQPHEGRDLAKRFNAQCIETSAKQRVNVDEAFIAVVRAIRRYQKESGPPQALATPGKTPTGGVGGRSTDQGDDHVNKGCCGSCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH08</accession>
    <name>A0A1Y2BH08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAC3/GANP/Nin1/mts3/eIF-3 p25 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_519145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH08"/>
    <dbReference type="FunCoup" id="A0A1Y2BH08">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BH08"/>
    <dbReference type="InParanoid" id="A0A1Y2BH08"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="2">
        <location>
            <begin position="108"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="296" mass="32369" checksum="A5D9A25708FC60C0" modified="2017-08-30" version="1">MHLLTMSSDLQQSLTELQQLFDKSGGSKAEVSQRLVKLKLELAQSGLYFAPPSGNVQDLVATRSILELGAFHSLRIGNLKAYRQYNSSLQPFYDNLSSILPPSPNRPITLGLHLLSLLSEGELTQFHTTLETLQVEQLNDAFVRLPVDLERWLMEGSYNRVYRARDRVPREEFGFLLERLMGTVRAQIAATIEASYPSLALESAATLLFYKSGENAALVSFAASRGWVLQPHSQIFTFPTSSKPDIAIAAESANANVSLNPAALDALHGKGIAKGVPMATLVGPALHLAQQLEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHI0</accession>
    <name>A0A1Y2BHI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_503569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHI0"/>
    <dbReference type="InParanoid" id="A0A1Y2BHI0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="231" mass="24593" checksum="ACB9B88A748BAB5D" modified="2017-08-30" version="1">MSPVPSGSDALSHRPPFTSSASDAPTPVPTQRPSRRRPTTAATNGVLEREKAASLVSLSLAACTGANLARVSDWFDGPFESRRQTYLDPPNLALTMISGSAGAVATHLATEGLPPEIQMILSSYLGCLSASICAHRNEIGRTDSEVPTAGTEGGGTVENPGDERPPSEATNCPSCIVHSVMHRWFNDAVHVVSPKSNSRVSDSPLGFPQVRRQRHAPNIQVCPLTIYTHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIJ4</accession>
    <name>A0A1Y2BIJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_513608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIJ4"/>
    <dbReference type="InParanoid" id="A0A1Y2BIJ4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="137" mass="15260" checksum="2BB4837F993EE21E" modified="2017-08-30" version="1">MAFLIGAAIRTGVKAVRQGVQAHEDFKQEGGPTERLDRWGNPKQHGPVYGMVMKAENAVAKHKGKGKEGQVEVPGVPDVQVNNEAELQQAHAEREERKSMDKTRPYDQGEDYGPQDYSRKPNEQVSFHSHSNRITPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJA7</accession>
    <name>A0A1Y2BJA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_556364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJA7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJA7"/>
    <dbReference type="InParanoid" id="A0A1Y2BJA7"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19204" checksum="BF9D5C3BE441B3C8" modified="2017-08-30" version="1">MKREGKHILIVVFYLDGTDPGVLIAADVAEGETEIQLYMTSVLATCPETKFVLFSYSFGTFAQVLALNNPTIPGFAISAIIYYGSAFWHPGKPENRGTATKGTSLAGNYSIATPAIYEPITADYCLYGDYLCTGTNVGDAHHKYLDSKWQTDAINFAVGRLKKDGIVESIVDTLTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJC9</accession>
    <name>A0A1Y2BJC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_515416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJC9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJC9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJC9"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="132"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="476"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="163"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="700" mass="77762" checksum="144C348FDD87F175" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJE4</accession>
    <name>A0A1Y2BJE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_517213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJE4"/>
    <dbReference type="FunCoup" id="A0A1Y2BJE4">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJE4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJE4"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="681"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="952"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1054" mass="114333" checksum="B1F8B546CCEBA849" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJF2</accession>
    <name>A0A1Y2BJF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_515471</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJF2"/>
    <dbReference type="FunCoup" id="A0A1Y2BJF2">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJF2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJF2"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="198"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY34898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="289" mass="30756" checksum="7ED673B120E84AD4" modified="2017-08-30" version="1">MSLSITRINVLPSTRTLASGVPFANKINHSLPPQAHGHGHSAGPRTDSPPTWAQKLSGSVSVLHVNTLPNTLVFSRSFSTSSRSSAQSGSAVGGISHHATTSQRHGPTGVPDFTPYRASDTSSNRTLSYFMVGALGALGASAAKSTVSDVLSNMAASADVLALAKIEVELGAIPEGKNLIVKWRGKPVFIRHRTSDEIDEANAVDVKTLRDPQTDDDRVKKPEWLVMLGVCTHLGCVPIGEAGDYGGWFCPCHGSHYDISGRIRRGPAPLNLEIPEYDFVEDDAKLLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJH9</accession>
    <name>A0A1Y2BJH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_556426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJH9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJH9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJH9"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000032">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="869" mass="99367" checksum="CB85B9E5626D742E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJM1</accession>
    <name>A0A1Y2BJM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_503294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJM1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJM1"/>
    <dbReference type="InParanoid" id="A0A1Y2BJM1"/>
    <dbReference type="OrthoDB" id="9975943at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="23419" checksum="4BB7338C1366C132" modified="2017-08-30" version="1">MVKVILTGATGNAGSAALIAALAHPLISAVTTLGRRGPYTENPAINPITVSDFTTFPPDLVSQVADHGAIIWALGISQTKVSSEEYVKITYDYTIAAANALKPLGTPEKPFRFIYVSGEGAAQDESGRAIFSKIKGRTEKALHGLQSEGFKTVSVRPGGILPMKEHKPRMSGWERYLLPPLGAVLSTVYPSAIINSFDLGIVLAELAAGTDGGNVGKGSKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKC0</accession>
    <name>A0A1Y2BKC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_516567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKC0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKC0"/>
    <dbReference type="InParanoid" id="A0A1Y2BKC0"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="505" mass="54324" checksum="A4C3C10FAD648A1F" modified="2017-08-30" version="1">MGEPSRPRVKVSGQISFTSSPSSSSIPPRVRAKVDPSTISTPPNVTTRPAIRSTPSSVSLRSGVSATSAGRARSPAPQLLATSTQTPIYTPPLSPPLTNDVSNQAVRVRGGPMYKSAKSPETPIYRSLTEVIGQSGPGPSSSAKAQPSSRGVTSVEGRIRPRAQPLTPTPTTRLLNRSYSRTPLISNSQPPNDQRAENHPYQSAPTISPDRPLLDAPRPVLNKSGAFPSLIHLQHPTASCPPSPLPASDLIIETHRSRILPAHPLYSKPPGLPPPTPGSPEIKTISLPELTPRTSGEYEYRYESEVSDLGKHDDDRDRLSGVTAVEVDLGKEGGVDEVIDDGNGDVEEAKVNRKIADLEISNASLLAINHSLEATKSKQRAEILRLRRALRDSLSGISQPFIPLTSPPIMSPSLMSPTPDDDTLFEEEFVDSELEVRWERVSELVGGMVRRGELAVEKGKEEVRLGTRVLGVEDITRESTPGPNDGEEDNSFASMPKDVGGEEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKZ9</accession>
    <name>A0A1Y2BKZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_509763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKZ9"/>
    <dbReference type="InParanoid" id="A0A1Y2BKZ9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="57" mass="5895" checksum="88C50ADFE95AECA2" modified="2017-08-30" version="1">MTQVARGKRRALPPVPTNVPVPVSSFPLSISVCLAAFPFQSPSILPSPCGVAICCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL29</accession>
    <name>A0A1Y2BL29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RNA-3'-phosphate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_489233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL29"/>
    <dbReference type="FunCoup" id="A0A1Y2BL29">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL29"/>
    <dbReference type="InParanoid" id="A0A1Y2BL29"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000001">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="7">
        <location>
            <begin position="189"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="381" mass="41789" checksum="9CAD082482DD5BE9" modified="2017-08-30" version="1">MPAPVTRPKSDILRFQTHHHLRQRLVLSILSGKSLRIDNIRSDDVHVGLRDYEINLLRLVEKVTNGSTIEISVTGTSFLFHPGLLPGGSHSHTCHVGRSIGYYLELLVPLAPFCKKPFDINLYGITGEQGRDMTVDMIRTVTLPHLHLFGIIDGLELQIKKRGAAPLGGGQVIFKSPVVRHLKTLNFVARGKIRKIRGVAYSTRVSPQFANRIVDSARSILNRYIPDIYLYTDVYKGDDSGKSPGYGLTLVSQSTTEALHASECLSNNQPTSSSSNPTSTLPQTPEDLGINAARLLLEEIARGGCVDSSHQWLVLLFMVLGKEDVGKCLFGNLTAHTIQFMRDLLLFFGVKFKVTPATNGTGEVLVSCVGVGYSNVNKAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL82</accession>
    <name>A0A1Y2BL82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_510486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL82"/>
    <dbReference type="FunCoup" id="A0A1Y2BL82">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL82"/>
    <dbReference type="InParanoid" id="A0A1Y2BL82"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="498" mass="56862" checksum="37637B9FD8AD4AB4" modified="2017-08-30" version="1">MAASLSHLGRGALRVAKNYTKGYTDTQSKVRDATSNDPWGPSGTQMNEVAQLTYNQNDFVEVMEMMDKRLNDKGKNWRHVFKALTLLDYCLHAGSENVVIYFKDNIYIVKTLKEFVYVDESGKDVGANVRQKAKDITNLLQDEERLRAERRHRGAMRDRMLGNIEQSGLKGEGDYGEPRSSSEHRQEPPRYLLDCYMANFRNPPPRSRNEDDDLQRAIAASMSSSEDEARRRNRLHQEEDELARALRLSQEEDERRKREQEAATTNALFDDNLNLTSNNQYSQQPMQTGYPLVDVGYGQMQPQYTSYNPFQAQMLQQQQQEEYMRQQMMLQEQQRQQEEYQRQQEEYMRQQFLQQQSLLSQPTGYGSNNPFAPAGQTQHSQQQIQPQQTSFLPVPVISSPQPPPQQPKPVDPQPTARPAFQPPKDDGQHSQLASLLARGREDGMDTFGNVGNLRIPVGSSFAQSNRLAVQQTGAQGLGGNNPFGQAQQKQSDQPFFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLB5</accession>
    <name>A0A1Y2BLB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_592001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLB5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLB5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLB5"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="273" mass="30925" checksum="086B258C15DC59CB" modified="2017-08-30" version="1">MTSFTGPHTHISAYYTWSPNPISDDAPFPFIPMLWGCNSTYTLPFQQAVENEFDRVGLTADHAILAFNEPDLVGQAECTPSQAASAWMHYLEPLKGKFRLGSPAVTSGPGGKQWMLDWFQACGGGCNPDFIALHWYDIDPEIFIEHIRDFHDTWNLSIWITEYAVQNFSQDATQATLEEIETFMDVTTSYMQSVDWVERDFWFGAMYDMQGVNNLDCLFDLSSGNVTDRTGALSPLGIKYAGISEQVEVSIHSPAPDSWISWTNDQRSRWYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLF6</accession>
    <name>A0A1Y2BLF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_515764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLF6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLF6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLF6"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF393">
        <property type="entry name" value="LIGASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="502"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="612" mass="66428" checksum="8F933F3400B67BDA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLL4</accession>
    <name>A0A1Y2BLL4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_555707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLL4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLL4"/>
    <dbReference type="InParanoid" id="A0A1Y2BLL4"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="337" mass="36824" checksum="D737DD9CFB0916E4" modified="2017-08-30" version="1">MYDADPMKDPVWAPGKNQPFNVWLEMHKPSQLNPDDDQWISISNTAKIQTDSEGDEDLRNAADKAWKKVAILEKRMMAIQKNVHLPVRATRVGQKTKAVAEAEARDELIADLKRLAEESACTSGKWLVHPKASEVDSTWSVIARSVLSGPLRKVGVLYAKVGTTGDFDSGGKPACEIRIHVIDAWDACLVRQVMETFLVKHGICPTAVKADLYTAAGIARDNPCRLRSTIWRPDELTPGGAREIRRLSMQFAAKINPSPGSSSVYSPSRSSSSSMQDQVSQPSINTLPSGSQTRGRADFIAKVGVGATFTPADMSRKENPCCACNFKLQDPSATART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLM6</accession>
    <name>A0A1Y2BLM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_511439</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLM6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLM6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLM6"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="308"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="570"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="652"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="690"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="843"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="935"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY35674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1039" mass="114492" checksum="CBC99C410EFD44B7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLP1</accession>
    <name>A0A1Y2BLP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_489551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLP1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLP1"/>
    <dbReference type="InParanoid" id="A0A1Y2BLP1"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="91"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="582" mass="63775" checksum="CB6A587BBA7A897F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLP2</accession>
    <name>A0A1Y2BLP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_511533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLP2"/>
    <dbReference type="InParanoid" id="A0A1Y2BLP2"/>
    <dbReference type="OrthoDB" id="5541877at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039966">
        <property type="entry name" value="C553.12c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="68007" checksum="A407D55BB0ABAB85" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BME5</accession>
    <name>A0A1Y2BME5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_556053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BME5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BME5"/>
    <dbReference type="InParanoid" id="A0A1Y2BME5"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="109"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY35929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="609" mass="68221" checksum="7CA6CCAB3E11B13B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BNN7</accession>
    <name>A0A1Y2BNN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_460873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BNN7"/>
    <dbReference type="FunCoup" id="A0A1Y2BNN7">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BNN7"/>
    <dbReference type="InParanoid" id="A0A1Y2BNN7"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="332"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="355"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="419" mass="46408" checksum="BBE1D0E26C38953F" modified="2017-08-30" version="1">MDPSIQPHREPNFALYQKEMFLLSQKGSHPAFSTHPDKLQEEAHKSLSQGGWLYASCNAGIGWTDRANREGKWRIIPRMLRDTTARDTTIELFGHKIAAPICFAPIGINKIYHPLGELNSSKVAGELNIPYCLSTAGSQPIEEVARVNGNGPRFFQLYCPHDEELEDSLLKRAWDSGFDACIFTLDTWQLAWRHEDIAASNYAFYRGIGAEIGLSDPVFKKRIAEAGLDPNKIEDMPKIGEKWIDNVWHGKAWTWEKVPKLVKKWKELSGGRPFLLKGIQHPDDAIKAVECGCDGIVVSNHAGRQVDGAVGSLEMLPEIVEAVGDKCTILFDSGIRTGADVFKALALGAKAVCVGRLFVYGMSIAGEAGVRHVMKSLLADFDILMNCAGVNSIAEIQKPQLRECISYFRECTISVLIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEN9</accession>
    <name>A0A1Y2AEN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_488587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000119">
        <property type="protein sequence ID" value="ORY21048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEN9"/>
    <dbReference type="InParanoid" id="A0A1Y2AEN9"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY21048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="485" mass="52783" checksum="2F6AD7E34A62EDFA" modified="2017-08-30" version="1">MENPMSMTPAVPVGHTIPGQQTEKASELDANVSYDGVSHVKPSWYRSVFFQVTIVGICAFLAPGIFNAMSLTGAGGAQSPYLVNTANAILYSLLTVFCIFGGLLTNLIGFRFALMLGASGYALYAGGLYANKVHGTQWLILFGAAMNGISGGIFWCTEGAIMIGYPEPRKVGRYLGLWLGWRNAGTLIGASINLGLNVNTKAAGSLSSSTYIVFIVLQCIGPLVGFFLSEPDKVQRPDGTPVLMKNPSPMAIEAKMMWTRVFTRWDVLALCPIMLYSTWFSSYAGTFLSLYFNVRSRALASFVTSFVSIMANVALGMFLDSTRISKKFKARFAFISVFFILNIAMWIWQTVMQVKYISSPPKALDWSAGATWYQGWGVYVMVLIMYNINANLLYWVISTMSDDPKDAVRLAGLLRGVEGAGGAGGFGMNTHKTLSKYVPLAFNFAFCVVSSIVAYPVIHRIGTPKANSPAPPSDITEVKEEVMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF27</accession>
    <name>A0A1Y2AF27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_554250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000119">
        <property type="protein sequence ID" value="ORY21034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF27"/>
    <dbReference type="STRING" id="71784.A0A1Y2AF27"/>
    <dbReference type="InParanoid" id="A0A1Y2AF27"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY21034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="389" mass="42817" checksum="16AB2B68C21E6021" modified="2017-08-30" version="1">MASPRPIVVLGAGIIGLTTAVKLLESPVYKLHGHPVHIIADHLPNDPLDAKYASTIAGAHHLSFAGDDDTRQSQWDRETFRVMHDEWSKEGEATGLMLLKQTEFYVGTSKHLKIYEEHPDFEIRDVKGKQPTADYSVSFTSITMTPLTYLNRLLKRIDTLSDGACQIHRFHLQSLDEVSHPAVTAFLGTAPPLAVFVCTGLGALTLGGVEDKTVFPTRGQVVKVRAPWIRSGFTRQVGDLNGGEDGERTYVIPRPDGEVILGGTREIGDWYPYPRPDTSGDIIRRVLEICPDLQPAHRRAKRGETVRGQSVDDSNSSPPSSPLEDLIVTHLVGFRPSREQGVRLEVGPDLILNGQRNIHVVYNYGHGGAGWQSCWGTASDAVKILETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFE4</accession>
    <name>A0A1Y2AFE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="12">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_554136</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="12">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 13">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="12"/>
    <dbReference type="EMBL" id="MCFC01000117">
        <property type="protein sequence ID" value="ORY21154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFE4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFE4"/>
    <dbReference type="InParanoid" id="A0A1Y2AFE4"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="16">
        <location>
            <begin position="61"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY21154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="472" mass="53003" checksum="486C169B7675CE3A" modified="2017-08-30" version="1">MSLTERDSHQVDGRSPERRSDKGKIWWSNGFFFIALHLFAIYGALYLSPISQVDKRTLILCFISFQSASFGITIGYHRLWSHRAFTARLPLRIALAWMGSLGFQGSIKWWVMRHRLHHRFTDSPVHDPYAATRGLFYAHCGWIFRKPTYSRMKLLDRTDLEADPVVRFQHRFFVPIAVFSGMALPYLIAKFGWNDGLGGLVWGGAVARLLIWHTTFCINSLAHWTGLQPYTEEVTARGNILLALLTSGEGNHNFHHAFPKDFRNGPHPADWDPSKWIIYILHRYTSLVPSIARTPEAAVVSAQARVHMAEADRLVASIPPSHKVKPKEDLPLWTKADVRKRHGQWIVDDGVRRRRVLLVIEGCVVDAGSYLEDHPGGEHLLLSHSIAKLSSFSVGANADDSGYSSSSPSSPPLGANCRLRAVSPGSSNSSQEDNEESVDLRDATRAFFGGMNNHSGAAKERMRCMRIARLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFK7</accession>
    <name>A0A1Y2AFK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_508495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000119">
        <property type="protein sequence ID" value="ORY21047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFK7"/>
    <dbReference type="FunCoup" id="A0A1Y2AFK7">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFK7"/>
    <dbReference type="InParanoid" id="A0A1Y2AFK7"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY21047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="440" mass="47538" checksum="56897182087C3296" modified="2017-08-30" version="1">MSLRSAVDEARTSYVARNPKSLECFRRAEESLPGGGTRSSIFIHPFPLFISKGEGTSLLDVDGHEYLDFVSDFTSGIYGKTNKVLRDAIVTALDNGIQLGAHTPFESRLASLIRHRFPSMELLRFANSGTEANLLAITTALKFTGRTKVMVFEGGYHGSLLSHFEVKKDQLVEAELVEEDRKNEVNVLTVPFDYLVAPYNDLAATKSLIQANATSIGAIIIEPMLGAGGCIPGDATFLRGLRQLATDVGAVFILDEVQTARLGFGGRQKTLGITPDLCTIGKFFGGGFAFGAFGGKLEIMQMFDSRRPGAVSHGGTFNNSPCTMVAGATALEQILTEPALEALNSIGDDMRDSINAAFKSLSAPYIVTGLGSINQLHCTLPGKLKTAGLDLVFFRLLERGYWIAQRGLISLNFAMSQSDVDGFVTAVIKVVREMQDLVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG16</accession>
    <name>A0A1Y2AG16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_508452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000116">
        <property type="protein sequence ID" value="ORY21230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG16"/>
    <dbReference type="STRING" id="71784.A0A1Y2AG16"/>
    <dbReference type="InParanoid" id="A0A1Y2AG16"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY21230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="240" mass="25898" checksum="B0EC5E0192174A0B" modified="2017-08-30" version="1">MLEAEQNIQLVVTGETAAGKTFSTHHLLGYLLNILQPVNQSMTGSTLEIVKQAEVILEALGNASTTSNDSSSRFSKRVQVIKRLNDKAISLLATDEDFHHSVPTDKDRPLSLSKYSELGISHYAGNVIYEATGIVRANKVVVPDGLANLLLSSGLNVVGKISVAIASTQGQGKLRPSKVVRWLRCIRPAVPGSIGWSKDYVQAQLEITGVKSIIATAPRRGRYGFLGAAQEVLDRYCLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHD2</accession>
    <name>A0A1Y2AHD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_474188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000100">
        <property type="protein sequence ID" value="ORY21979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHD2"/>
    <dbReference type="InParanoid" id="A0A1Y2AHD2"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012914755" description="Glycosyl transferase CAP10 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="304"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY21979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="623" mass="71294" checksum="28D795469426FE32" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHJ2</accession>
    <name>A0A1Y2AHJ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_552403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000099">
        <property type="protein sequence ID" value="ORY22031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHJ2"/>
    <dbReference type="FunCoup" id="A0A1Y2AHJ2">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AHJ2"/>
    <dbReference type="InParanoid" id="A0A1Y2AHJ2"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="470"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="512"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="647"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY22031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="692" mass="74368" checksum="D8FC067C265B97A5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHN9</accession>
    <name>A0A1Y2AHN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_552290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000099">
        <property type="protein sequence ID" value="ORY22016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHN9"/>
    <dbReference type="FunCoup" id="A0A1Y2AHN9">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AHN9"/>
    <dbReference type="InParanoid" id="A0A1Y2AHN9"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="28"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY22016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="861" mass="94554" checksum="EE42438BF6297561" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI12</accession>
    <name>A0A1Y2AI12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_474024</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000096">
        <property type="protein sequence ID" value="ORY22229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI12"/>
    <dbReference type="FunCoup" id="A0A1Y2AI12">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AI12"/>
    <dbReference type="InParanoid" id="A0A1Y2AI12"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="247"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY22229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="555" mass="63310" checksum="14E59F2C00025DA8" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIB6</accession>
    <name>A0A1Y2AIB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_552317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000099">
        <property type="protein sequence ID" value="ORY22020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIB6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AIB6"/>
    <dbReference type="InParanoid" id="A0A1Y2AIB6"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="693" mass="74699" checksum="2E27ACCDD29A0AAA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIU3</accession>
    <name>A0A1Y2AIU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_551455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIU3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AIU3"/>
    <dbReference type="InParanoid" id="A0A1Y2AIU3"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY22503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="276" mass="30233" checksum="0B0F4A19F203C101" modified="2017-08-30" version="1">MGDKVQGFDLGDRICADVGETCGWCHYCRKGQELFCEHFSPAGVARDGGFADYIKYHFSKCYKIKNLTDEEATLLEPASCAIHGMDKLKMPFGAKVLLIGAGPTGLILAQLMKMGGAGHITIAANAGIKMDIARKVEAGDAYIDLDRQNAKAQWEQIKQDNPHGFDVVAECTGVESIVNDAINYVSRGGTLLVYGVYADKARVSWSPTKIFVDEINIIGSFSQTYCFPRAIDLLDSKKIRTTGMVTDVFELKDYQKALDKMSSRGALKIAIRPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJD6</accession>
    <name>A0A1Y2AJD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_551019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000089">
        <property type="protein sequence ID" value="ORY22689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJD6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJD6"/>
    <dbReference type="InParanoid" id="A0A1Y2AJD6"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36577" checksum="58A3142C1BFF2B2B" modified="2017-08-30" version="1">MNYPVIVYDVDSSQPDPDAVYFRGPWHKILWDDTVLILRSAREIPNIFLPLPTLGIRAGPGNLKDITNWGAIFQAIAILVSFIITIGGIFAFFLGVPMPFVAYAILVIFLQINVRIQGPETRVSRPADDEKAFKKEAWLFVNGIATSGSGVQLSVDFLREKFGRQVIGICNRTQGIWFDLVECMLQRDLLWPTQDVNLGYAILSAKIRDQNLKRVVLIAHSQGGIIASTWLDQLLADFPTSQLNKLEIYTFASASNHFSAPSDGSLSSPFGRIEHFANSRDFVADIGVLAFAPNENRAVMPPGGTVPKAGGRYAGRIFKRIGHTGHLLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJK5</accession>
    <name>A0A1Y2AJK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_552165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000098">
        <property type="protein sequence ID" value="ORY22125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJK5"/>
    <dbReference type="FunCoup" id="A0A1Y2AJK5">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJK5"/>
    <dbReference type="InParanoid" id="A0A1Y2AJK5"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="257" mass="27622" checksum="016F239A1CEA88D5" modified="2017-08-30" version="1">MSSIGTGYDLSVSTYSPDGRLFQVEYASKAVEAAGVAVGLRCSDGVVLGVERLLHSKLLVKGSNRRIQSVDDHIGMATAGLLADGKHLAERGRDEASNFRDTYAQPVTVQILSDRLSAYVQAYTCYGSVRPFGISTLVGGVDKTGSRLFCIEPSGVFYGYRATAVGKGRALARTELEKVLGKVDEAGEGSLTVRQGVLELARIIHLVHDDNKDKEFELELTWVCEESGNKHALVPADLLAEADAKGRAALEEGMEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJS0</accession>
    <name>A0A1Y2AJS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative heterokaryon incompatibility protein HET-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_487655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJS0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJS0"/>
    <dbReference type="InParanoid" id="A0A1Y2AJS0"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011006388" evidence="2">
        <location>
            <begin position="25"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="789" mass="86732" checksum="C26166756083E41B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJU8</accession>
    <name>A0A1Y2AJU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_551433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJU8"/>
    <dbReference type="FunCoup" id="A0A1Y2AJU8">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJU8"/>
    <dbReference type="InParanoid" id="A0A1Y2AJU8"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="452"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="570"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY22497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="606" mass="62894" checksum="EE4EFBC63CFE1150" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKV1</accession>
    <name>A0A1Y2AKV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cortical patch SUR7/pH-response regulator pali</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_549724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKV1"/>
    <dbReference type="InParanoid" id="A0A1Y2AKV1"/>
    <dbReference type="OrthoDB" id="2570109at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39078" checksum="1430C92017E5AB48" modified="2017-08-30" version="1">MKFPSKMKLDMKKYEKYTHHPILSQTIISLGLTGLSLLLLVLVLLSVPGPIKGLYWFSVPGETSGVGDLTAGVLGWCETATSNCTYAPLSDNHFLSTLINTGEALTVRIMLPLACYWAIVVLVFWVLLTVLTPIGYAIKDLDSITRHLRFAIIEACVLCVTLFGNVLSWLAFGLGREAYLSVKNGGGTVHSGRAMETTAVAALMSLFSLFAAIWGLHLRVSKAQTQWKEEAVMVRRRSMAMLGNSNSISNGGGVGNLPINLDVENGHVGIHSDPNQLGMQREKNDSTRWSDAPSYSAPQAQTQRFSIQKERLEENVHSGIERGGEHDDEEERLDAELATAKRNSVIHKELISRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALH4</accession>
    <name>A0A1Y2ALH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_507949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALH4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALH4"/>
    <dbReference type="InParanoid" id="A0A1Y2ALH4"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="306" mass="33154" checksum="9B3AC6C727F85200" modified="2017-08-30" version="1">MEPRILLVAAATGTQSGATIKALVASSTPGVSIRALVRSKASEKAQALVGVELVEGSFDDSQSLKNALVGVDSAFLVTTPFGEGQSPEAEIRQGKAFIDAAKGAGVKHLVFTSVEGAERKTGIPHADGKHEIEQHLFASGMRYTVVRPVIFMDLFPLSVGAELAINLWTLEVFLRGRKLQMVASEDIGWSFLSASFGWFCAQALLNPADYGGRQIPLAGDALTMAEVRATYAKVTGQTPWNLYLLPGFLVKWLPIPPLFLKTLTVSIFYMWYGSTAGYEADVEARRAEHPAMMTFETWLSRKIKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALK7</accession>
    <name>A0A1Y2ALK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_550742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALK7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALK7"/>
    <dbReference type="InParanoid" id="A0A1Y2ALK7"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="373"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY22835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="461" mass="49893" checksum="1F37BDB34EBF19BC" modified="2017-08-30" version="1">MFRFRLRTPSFSLSSLSSLKMQASTNASRVLIVGGGIGGLSLAQSLCRTSIPFTVFERDPSPKFRAQGYRLGHNQMGDESLQSVLGEELYKKLRAMGAGEEDRGLKAAGVRADAVSGETLGSGPMGGNPASFATMKKAGDAPPAAQGPRVRAFTSDRTILRSMLGLGLESHISYGKRFSGFSLSDDNTLVTARFDDGTSESGAVLVGADGIQSRVYSELLSVGQQPPPIRLDLERRCIYGKTRLTPGFEAAFPEKWRKGMSIFKDPTNDAKVLFMDPVIFNNKAEDLTEGMVTTPENYLYWVISTQKEEIQMGDEEFLSLAPEKAVEMSLKLTQHWNPQLRVLLEKQDVQQCAALRLVSAPPNIPERPSHSSVTALGDAVHPMSPAGGSGANTAIRDAAVLGSLLKDAWQDKWEPGAIARAIEDYEGQMRGYASQAIAGSFRAGKMMGGMKDAEEYKPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM89</accession>
    <name>A0A1Y2AM89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_548940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM89"/>
    <dbReference type="InParanoid" id="A0A1Y2AM89"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000295">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="70"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY23616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="539" mass="59212" checksum="73D4BEEDA625D542" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMA3</accession>
    <name>A0A1Y2AMA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_548936</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMA3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMA3"/>
    <dbReference type="InParanoid" id="A0A1Y2AMA3"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="14">
        <location>
            <begin position="512"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="379"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="876"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1201"/>
            <end position="1233"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="300"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
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        <location>
            <begin position="1033"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
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        <location>
            <begin position="1206"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY23614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1233" mass="132728" checksum="3999853543130AB1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMS1</accession>
    <name>A0A1Y2AMS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_561802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMS1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMS1"/>
    <dbReference type="InParanoid" id="A0A1Y2AMS1"/>
    <dbReference type="OrthoDB" id="29308at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
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            <end position="220"/>
        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="776" mass="84814" checksum="11F07E01C00071E5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN80</accession>
    <name>A0A1Y2AN80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_339596</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN80"/>
    <dbReference type="STRING" id="71784.A0A1Y2AN80"/>
    <dbReference type="InParanoid" id="A0A1Y2AN80"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="138"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="262"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY24009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="408" mass="44186" checksum="2485AFFE4D4750C2" modified="2017-08-30" version="1">MSTQPLTPFGSALAGALGAVFSNAVVYPLDTVKTRLQALPTSSTQDQPVIASTDVEKGSRHGSVPSGVPAHLVKRLRRFKMLSLLLTIIRTEGPGGVFKGFSANMLNTFSQQFAYFFFHTLLRTRILASRPASPPPRLSTALELFLGALAGALAQIFTIPVAVIATRQQLYTPPRPPIQQPTASQHPNTSSSSTTLPISTQQSSPGFTETAKEIIQESGWTGLWTGLKPGLVLTVNPAITYGVFERLKSAVLAGRAGADARLGVGEAFWLGVGSKTLATVVTYPYIFAKVRLQAKTTDNDDKEDDTTTVSTDAIESTKNQDIDGDEQKTSQSPLIAADKKQNRQRGAIPLLMQVYKQHGFAGWYQGLSAQIVKAVLCQGILFVSKDQFEVYAAIILAIMTRFRQRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APE3</accession>
    <name>A0A1Y2APE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_546687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APE3"/>
    <dbReference type="STRING" id="71784.A0A1Y2APE3"/>
    <dbReference type="InParanoid" id="A0A1Y2APE3"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="185" mass="20354" checksum="1F0986E41F931B38" modified="2017-08-30" version="1">MAIGTEKKNLPNVFFDIQVGADTTKKRVEFKLYDDVVPKTAENFRGLCTGKKGDGSPLDHPKFTYKGTHFHRIIDQFMVQGGDFESHNGRGGQSIWGGKFEDESFHIKHTKPGLLSMANAGPATNGSQFFITTVPCSWLDGKHVVFGEVVKGFEHIDALQKTGNRDGSVPKEKRAVIVDCGAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ29</accession>
    <name>A0A1Y2AQ29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_320223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ29"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQ29"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ29"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="471" mass="49885" checksum="C54453145CA7F38D" modified="2017-08-30" version="1">MGLPLPSLPSLPALPSLSALLDPSPPVFYPSRSRRPSTSSLSSAPTLAEDCPALHASASANRLTGEWKPLARRTSVTSLRSTSSSPAIARPSHRRAHSAIPSGRIPLPLPIKPYHAGSSAISLPTLSEIDQVNHSDSSSSSSYSSSFSFSAQLSGAETPPSPVSIASPASFKCSVPPPLPAGTMPPPPRPQTFNQRRASVSGISDVNVLARWSFPSSPSDTAEEHTSVDPEDMGDDREGSLKGRLRRLSRLDTSMPPPPLPHRASTPTHPPTFSSPATPPRRHLPPHLTHRHTLSSPGAMHASASLPSSLHTLGADHADVNKSRPRRPTTSRLRQPNLLSMPNPSGEIIDSIRGRTFEKRISASSDLDVAMRPPGYSTSLPRDAHGASNLLSVGGGRPVGWRNRLAAIRLHGGYRSMSDIREVSGGAMVNNGNGGIGIGIGGSDVNRNRNAVTDTEGGELDQEEYIDFDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ66</accession>
    <name>A0A1Y2AQ66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Metal resistance protein ycf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_546075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2AQ66">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQ66"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ66"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000078">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
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        </location>
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    </feature>
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            <begin position="576"/>
            <end position="594"/>
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    </feature>
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            <begin position="606"/>
            <end position="628"/>
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            <end position="1026"/>
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            <end position="633"/>
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            <end position="1563"/>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS50929"/>
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        <source>
            <dbReference type="EMBL" id="ORY24672.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1570" mass="172654" checksum="EC0349CF54A8B07B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARM8</accession>
    <name>A0A1Y2ARM8_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BCR39DRAFT_544991</name>
    </gene>
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        <name type="scientific">Naematelia encephala</name>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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</entry>
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                <person name="Labutti K."/>
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                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
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                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="270"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY25170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="303" mass="34044" checksum="A0E3B9C55A347C85" modified="2017-08-30" version="1">MLVLPARSKRPRSPSPDLAEQLSSPLDILHKRRRREEYWSDPLLPPQALYEPEYVDAESSSAAWTRASVNGRRSRQWQYLNAPQTHSSHSHAAEPSSPIPMPRAASQPDPSSRRGQMSSSPIRHHPPSSSPFKSSETRIDDWIGLEEMEREWGAEYTAQNSLLHNLHRARVGHSNMEPSILNSVLPNTPALPTAEQYRTQAPSSISTHSTHFDTHLTPYRYTAAFPSSGPTPYRPGHFPSSPLARDHGIDGMDQDESMDMDDEADGGQAEEEVRKTYEETNRLLAELEVVRRTRWGGNGAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATE1</accession>
    <name>A0A1Y2ATE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rad52/22 family double-strand break repair protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_560930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATE1"/>
    <dbReference type="FunCoup" id="A0A1Y2ATE1">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATE1"/>
    <dbReference type="InParanoid" id="A0A1Y2ATE1"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="59145" checksum="44B7A13C537BEC76" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATZ6</accession>
    <name>A0A1Y2ATZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_542733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATZ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2ATZ6"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18942" checksum="903C1120957D78A8" modified="2017-08-30" version="1">MAVNVDFPQSPGRPFPILPGENVLTEGNTADLELRIPPTPSGPKRTETAKGRIWVTDHRVIFISERQATSTSTSTGYDAPPTLDSLVIPYSHLLIASFNLPLFAPNNLILSFLPSSPESSSHLPEVGRGGKIEAKLVVGEGAGHGIWKRIEGERSRYVERQIEEESLPVYTAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUA7</accession>
    <name>A0A1Y2AUA7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_541941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUA7"/>
    <dbReference type="InParanoid" id="A0A1Y2AUA7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="112" mass="12714" checksum="4986615F857E1BC7" modified="2017-08-30" version="1">MKQVQTSMSFQLNRDTASDRRSLPIYIEADRPTGLCLADFRTPKGEYKRYKGSVLIISLPTAVHIINIAKLVVWRQHVITQLLLFCSPHTPLIERPSIIMRTGGALRLLPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUL6</accession>
    <name>A0A1Y2AUL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">BCR39DRAFT_470655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUL6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUL6"/>
    <dbReference type="InParanoid" id="A0A1Y2AUL6"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="257" mass="28427" checksum="365992F083206637" modified="2017-08-30" version="1">MSLVPPHLPSPAATPDEHLATQAAVSVDSEQRQAQIRAEVEAQLLRLSQDLYEMEICAGEVGMGMEERVPRYMMEVSEALVRLEELSGRMEDSVPKQILEYNRAVDQHRNPHVYTKSTLTRAAGENQYALGRMLGLENFRRQLQSALAEEFPSVDLPDRRHVPDWERNAGQIKENGEVDLKENGESGVRENGESGVRENGESEVKENGESGGEHNGESEIKVEDGDTVPNGQVEGHVFVQNESLELTPTTTPANGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUS2</accession>
    <name>A0A1Y2AUS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_541248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUS2"/>
    <dbReference type="FunCoup" id="A0A1Y2AUS2">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUS2"/>
    <dbReference type="InParanoid" id="A0A1Y2AUS2"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012395308" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="28"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="272"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="502"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="722"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="813"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="841"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="893" mass="96295" checksum="6CC98093D2722516" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV02</accession>
    <name>A0A1Y2AV02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_542327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV02"/>
    <dbReference type="STRING" id="71784.A0A1Y2AV02"/>
    <dbReference type="InParanoid" id="A0A1Y2AV02"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="319" mass="35463" checksum="E89F00FC2041C8EB" modified="2017-08-30" version="1">MAPSCTLQECVIDASAPFEDIYNLLILRGGIVVKNLLDVDTCMQMKSELQPYLDAQAPKPGQEWQGSFFPKTTRKVSGVLTRSKTFGTALTMNPLYLALNDRILSRRNKMRNTQTPKWSTAKPQVNQTSILEIHPGAIEQDLHRDDCIFHRVLPAVDKWTVGRDVSTLCFVALSKVTPANGGTLFIPGSHLTGYEYAPKKEDALRAEMEIGDAFIMLCHTYHGGGSNTMKEGEANSVRTLAATGMTLGFLKQEENQYISHDIEKIAQLSPELQELAGWNISLPYLGWVDFSHPARTLGRHIPDGDHLFFDEDQSEAVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV74</accession>
    <name>A0A1Y2AV74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_470349</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex, at least composed of TIM23, TIM17 and TIM50. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV74"/>
    <dbReference type="FunCoup" id="A0A1Y2AV74">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AV74"/>
    <dbReference type="InParanoid" id="A0A1Y2AV74"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="16">
        <location>
            <begin position="214"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY26471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="496" mass="54659" checksum="3AE48345CB0D38E2" modified="2017-08-30" version="1">MIRQSLIRLAAAAPRRNLATSTRILRSRGDRNRNFNSNPSPAERPPRPPQDDSAPSQAFEPIVNRPASVPTPESLESGSIPLTPPPPPAQPSGPTEEPVTTSEPDLSQLPSLDIEPPAQEAIPPPSGGADKGRTGARGKEYVTSTERSRRLYAQLGVAAFVVGGLGAMYFGSGSDESKGSIGAWARMKGNLTEMFDVFNKPAFKTLLPDPLPPPHQRKYTLLVDLEGMLVSSTWDRQSGWRTAKRPGVDYFLAYLSQFYEIVLFTSQPLYTAMPVAEKLDPYQAYLPYKLFRESTRTAGGKTVKDLTYLNRDLSKVILLDTNPEHAALQPDNAIIIKPWTGQGGDKGLVDLIPFLESIPIYNAADVRPVIKAYEGKDIPTEYAKREAEAKRIAVEEWERLHPTSLHGAGSGFLSGLFGSVSNPGYSRPNRPMTYLEQKRAEAQKTYQDEQRYWAEHAEEFAKLIEDDKQRQLAEMKGSLLGFLSGGAAAPKPEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVM0</accession>
    <name>A0A1Y2AVM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_254584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVM0"/>
    <dbReference type="InParanoid" id="A0A1Y2AVM0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="165" mass="18587" checksum="0D5B93C42521083B" modified="2017-08-30" version="1">MARESLRKLHCCLQLTDGRDGSAQRWILKGSVETRRRVDGSGKTLLTPSILMERRGPMQMVNASRLARAFMAKRNEANTSRKDTGSTQTHPRLDMQSPHDNPGPVQISNHHFFQCSPSLVPVRSEDQVSYFCLSVTPPNASQTWSQTHKPFDNHNSSLSTLRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVU6</accession>
    <name>A0A1Y2AVU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_540601</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVU6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVU6"/>
    <dbReference type="InParanoid" id="A0A1Y2AVU6"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY26574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="165" mass="17985" checksum="76BACBBC6D423373" modified="2017-08-30" version="1">MASSAVTPADYHKIMRVAYDQAIKSLSEGGIPIGAALVHLPTGKIMAKGHNNRVQMSSNIRHGEMDCLENLGRVSEGVLRECAMFTTLSPCIMCSATCTLYKIPLVVLAENRNFLGGEDFLKGKGVQVVNLDDEEITKMMGDWIKSEAGQKVWNEDIGEVSIPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVX9</accession>
    <name>A0A1Y2AVX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_540450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVX9"/>
    <dbReference type="FunCoup" id="A0A1Y2AVX9">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVX9"/>
    <dbReference type="InParanoid" id="A0A1Y2AVX9"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000017">
        <property type="entry name" value="Oxysterol-binding protein homolog C2F12.05c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="290"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="642"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1157"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1210" mass="132925" checksum="52E56FBAEE32349B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW38</accession>
    <name>A0A1Y2AW38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_249918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW38"/>
    <dbReference type="FunCoup" id="A0A1Y2AW38">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AW38"/>
    <dbReference type="InParanoid" id="A0A1Y2AW38"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="18"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="562" mass="63513" checksum="504ADADF2C47D4EC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW79</accession>
    <name>A0A1Y2AW79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_589822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW79"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW79"/>
    <dbReference type="InParanoid" id="A0A1Y2AW79"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="671" mass="73060" checksum="F0F0FC5012503552" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYA7</accession>
    <name>A0A1Y2AYA7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_539840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYA7"/>
    <dbReference type="FunCoup" id="A0A1Y2AYA7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AYA7"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="387" mass="44088" checksum="4D0D393073672AF7" modified="2017-08-30" version="1">MLPLPNSSSSSRPNKSRMFFPSSTSPHPSYSSTTHQIITTLRSRTRLTNLAVSLLLLLLTTSLLLNLNTLLLRPSTYHPGRRKWEGWEDNATPQQLDSGIPLSIETTIERDPRFEELDHLIMVPGHAIWIGNDPERLEEDDQWILEGIQGGGSVKTYVKHIREGVRRLESDPNSLLIFSGGATRLPPSPPLAEAQSYLNIATALRLIQPASLPPLSSPLPLYLRTATEEYALDSYENLLFALARFKEVTGRWPVRVTIVGYGMKRRRYEHLHRASINFPLEQFEYFGIDDEGDTTEHYAGELKYGYTPFLSSPSGCHPPLSTKRLLRNPYARYHPYHTSCPEISDLLEWCPPLVNPPQGEDAPGAIYEGWVPWRDMDDQIRWGREWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYS0</accession>
    <name>A0A1Y2AYS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_247083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY27005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYS0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYS0"/>
    <dbReference type="InParanoid" id="A0A1Y2AYS0"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="710" mass="79470" checksum="EC553843AC07928F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ30</accession>
    <name>A0A1Y2AZ30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_217976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ30"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ30"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ30"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="160"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="619" mass="67712" checksum="EC87A155E16F91BE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZJ6</accession>
    <name>A0A1Y2AZJ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spc7 kinetochore protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_211613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY27998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZJ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZJ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AZJ6"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="546"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="729"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1047" mass="114995" checksum="BFA0B91DD1EAE5DB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZU9</accession>
    <name>A0A1Y2AZU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_537064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZU9"/>
    <dbReference type="FunCoup" id="A0A1Y2AZU9">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZU9"/>
    <dbReference type="InParanoid" id="A0A1Y2AZU9"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="319"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="410" mass="43678" checksum="871F430A4633CCAB" modified="2017-08-30" version="1">MSSAGPSSGADSSTDDERPLTLEEYERYGRQMIMPDFGLPGQARLKRARVAVVGAGGLGCPVLQYLAGAGVGTIGIFDHDHVSLSNLHRQVLHTTERVGMNKARSAQLAINALNPNINALAISEAILPSTAEELLTNYDILVDCTDRPLTRYLLSDLSVKLGIPLVSGAAISSAGQWAVYGGDVKGKRRACYRCLWPKVVHGSGSEGVCEEVGVWGVVVGMVGVGMAGEVIKLIIGKEDEQPLLQLLHLGGNPLVRTVRMRGPRKDCVACGEAAVLPAKLEEMGYDEFCAGPASSVAIDQAAVERMRARDLADILKTSDTPRPLIIDTRPQVEYGICSLPGTTNIPFDTILSSLDAVPPSTDVVFLCRKGNDSQVAAQALAKTSPSTRVRDVRGGLVAYSREVDPTFPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZY0</accession>
    <name>A0A1Y2AZY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_535599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZY0"/>
    <dbReference type="FunCoup" id="A0A1Y2AZY0">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZY0"/>
    <dbReference type="InParanoid" id="A0A1Y2AZY0"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000005">
        <property type="entry name" value="50S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="148" mass="15661" checksum="48407611B4E6DF52" modified="2017-08-30" version="1">MSKAAATAVQFVKLTVPAGKATPSPPVGPAMGARGVKAIDFCKEFNARTADYIPETPIPCLVKISPDRTFTFETRTPPVSYLLKKAAKIEKGNGLSRASPTAGRISLKHIYEVAKIKCLDPDLEVVGLEKVAKSVLGSAKTLGLEVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B158</accession>
    <name>A0A1Y2B158_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_534801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B158"/>
    <dbReference type="FunCoup" id="A0A1Y2B158">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B158"/>
    <dbReference type="InParanoid" id="A0A1Y2B158"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="111"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="557" mass="61095" checksum="A552EF3D1BB02E74" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1A3</accession>
    <name>A0A1Y2B1A3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_468091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1A3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1A3"/>
    <dbReference type="InParanoid" id="A0A1Y2B1A3"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="159" mass="18130" checksum="FC53383034247A33" modified="2017-08-30" version="1">MQAAAGGIFPSALTFDTMVRDYLNNLSPKKREKALLSQYMYDNVMAVLHDPNCTSIGTAQFRFWAKKMFSLTSFGEETVIVHDGKPVAVKEQIYEVLTHCHAQASHGGRDKTSAQVRRYYSWIPKEIIARYVRDCPFCQNRRTSNSSNTRMSSSQAFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1M7</accession>
    <name>A0A1Y2B1M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_468166</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1M7"/>
    <dbReference type="FunCoup" id="A0A1Y2B1M7">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1M7"/>
    <dbReference type="InParanoid" id="A0A1Y2B1M7"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="379" mass="42551" checksum="8E050005E3AF0361" modified="2017-08-30" version="1">MVRRLKAGGGEVQTVQAAKPTVHTIDNADDTDGYYRITPGEILDNGRYQVTINLGKGMFSAVVKAKVLKAVDQERRQDVVGKEVAIKVIRSQESMYVAGRKEAGILKKLNDADPEDKKHIVRLDRTFEHRGHLCIVTESLSMNLRDVIKRFGKDVGLNMRAVRAYAHQMFLALSLMRKCSIVHADIKPDNILVTENKATLKVCDLGSASEVSDGEITPYLVSRFYRAPEIILGLPFDMAIDVWSVGCTLYELYTGKILFPGRSNNQMLLLMMEVKGKLSHRLIKKASLGEMHFDESMNFISIEKDKITGADVAKTLVVSKATRDLRSRLLPPSSVQIKMKDDELKLLKNFVDLLEKCLELDPARRITPRDALLHPFLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2H9</accession>
    <name>A0A1Y2B2H9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_185216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2H9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2H9"/>
    <dbReference type="InParanoid" id="A0A1Y2B2H9"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="8">
        <location>
            <begin position="52"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="202"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="65570" checksum="989EE40D5B4A51DC" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3G3</accession>
    <name>A0A1Y2B3G3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_565179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3G3"/>
    <dbReference type="InParanoid" id="A0A1Y2B3G3"/>
    <dbReference type="OrthoDB" id="2594971at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29047" checksum="C7FBACAAACC9AB5F" modified="2017-08-30" version="1">MSSEAESSSQALERFLSSQLASLSLTVPQDDVEFMSRFIEEEGLEREEKVEGARAMLEGVIEEGELPLEGVDDVLGKAIDEWTRLKKEEEDRLAEEDASSSEEDERTSKPADILASLTPEELAAAQRQALLRQYAYVEGSAEEEEERRLGAGAPPRGDSVKRTEEEKAAEERRRLVEAAIRLDSKKKKHKKAKQVDLLAPNLNKDKAIYLTQIQRDAQKKASAERRDRDKAALEKQKADQVKAKADKQKKTAKQERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3H1</accession>
    <name>A0A1Y2B3H1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_532534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3H1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3H1"/>
    <dbReference type="InParanoid" id="A0A1Y2B3H1"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="563"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="645" mass="67953" checksum="4D79B201E796C47A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B457</accession>
    <name>A0A1Y2B457_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_531228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B457"/>
    <dbReference type="FunCoup" id="A0A1Y2B457">
        <property type="interactions" value="536"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B457"/>
    <dbReference type="InParanoid" id="A0A1Y2B457"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14280">
        <property type="entry name" value="UBA1_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="404" mass="41508" checksum="6B2718A36B16F4A6" modified="2017-08-30" version="1">MVKITFKTVQNKLFTVDAEESETVGDLKKKIQETQTFPAENQKLIYSGKILNDQATVSSLKIKEKDFLVVMVSKPKAAPAPAPAPTPAPAPAPVAPEPVAEPTAAPAEATASSSTAPAATSETSTAPPAEPATESAPSGLTQGSFLAGPALQQAISGMVEMGFEREQVMRALKASFNNPDRAVEYLMSGDIPNIEGTGPSAPAPTPAVPTPAAAAPAPVTPAPAPAPAAAPAPQTTSAPAPGGSAENLFAAAEAAMNRDRGTPAGEAPSAAPAGLGAGAGGLADMANSPQIQQLRQLVQQNPALIQPLLQQIATQYPELAQLLTQNPEALYDLLGAGPGEGDDDEDMAGGPFVQVNLTQDEAAAVERLEQLGFDRNVVLQAYMLCDKNEELAANFLFEHGDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4P7</accession>
    <name>A0A1Y2B4P7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_558921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4P7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4P7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4P7"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="623"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="697"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="904"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY29803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="101476" checksum="DAAA97703EC3A5DC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B554</accession>
    <name>A0A1Y2B554_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor slt11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_481437</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B554"/>
    <dbReference type="FunCoup" id="A0A1Y2B554">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B554"/>
    <dbReference type="InParanoid" id="A0A1Y2B554"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY29617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="291" mass="32234" checksum="4BA87A87C61C64E4" modified="2017-08-30" version="1" fragment="single">MPAKHDINKVGVESSDFPILCETCLGPNPYVRMAKFGNECKICNRPFTVFRWNPGSGGRFKKTEVCTTCAKIKGVCQTCLLDLEFGLPVQVRDAALGRKNQAPSSDINKQFYIQNLEAQMEDSPDGQAYDAEVASRAGREMLKGIARTDPFYKRNRPHICSFFVKGDCKRGAECPFRHEVPEEGALSKQNMTDRYYGRNDPVAKKILREQSEAKGMKTPDDQTVTTLLFLGLPKTDEAAIRSSLSTTVPSVKPTEVRQISIVEASNCAFINFVNRPVAERAAEALSIQGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B565</accession>
    <name>A0A1Y2B565_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_530355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B565"/>
    <dbReference type="STRING" id="71784.A0A1Y2B565"/>
    <dbReference type="InParanoid" id="A0A1Y2B565"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="5">
        <location>
            <begin position="413"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="729" mass="78942" checksum="DC6674B6D2741E78" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5F0</accession>
    <name>A0A1Y2B5F0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5F0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5F0"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="252" mass="27288" checksum="674A32554DC9CA08" modified="2017-08-30" version="1">MAAKKDEQPSTFTPVHPFDMEDPRSWGATIGMMHWDNDKIVFSKRSLLEFLKSCQLTVNTNFTEISKLPKYATFGRLSQAATDAAVADLVEAEIADPTTDSPVHPSKSTVPRFSRKVVDAPGGKQNIRLFGEEYEETDALSLAPPRDGGDGVDVEIERLERLKVHVEPAVEGGAKIEEPKDEPAERVTNPPPGFKPSRKVREGPGGPSTMGQTLFGGYEDETDADRSAATARTGGRKPSPQPPSSSAGGNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5T8</accession>
    <name>A0A1Y2B5T8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_587988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5T8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5T8"/>
    <dbReference type="InParanoid" id="A0A1Y2B5T8"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY30198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="609" mass="65532" checksum="35CBFB310BE2CB2F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5X6</accession>
    <name>A0A1Y2B5X6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_530235</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5X6"/>
    <dbReference type="FunCoup" id="A0A1Y2B5X6">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5X6"/>
    <dbReference type="InParanoid" id="A0A1Y2B5X6"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY30249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="532" mass="61255" checksum="643D8DFC886B8A0E" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B896</accession>
    <name>A0A1Y2B896_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_494590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B896"/>
    <dbReference type="STRING" id="71784.A0A1Y2B896"/>
    <dbReference type="InParanoid" id="A0A1Y2B896"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="235" mass="26519" checksum="67AABDF49C4B845E" modified="2017-08-30" version="1">MSVSSAVAPKPEWVEKFESIVKPSQDYTTYALSTLNPEGKPKVRHVIHRDLTPSALFLTTTDTRMQKPVHLRHDPTVEIAWWIVEPAVQFRITGQAYVIPPANEADSASKFHDILTGLGLDPDKNVEGKPEWWEGQRKLLWDKAMSGHLRGSFGRPPPGTPLSEIEQKPEDWISSLPNDSDDPKVKKDIEYALSHFALLAIKPTGFELLELKATPNKRTQWTLKGDEWVRVEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8A0</accession>
    <name>A0A1Y2B8A0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_528099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8A0"/>
    <dbReference type="InParanoid" id="A0A1Y2B8A0"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="430" mass="48084" checksum="77E7BA1FB3C9AD61" modified="2017-08-30" version="1">MDWHLLGDSVSQAFSVSTSIKVVEAAIKYGGKDGITLPTTCPEYTAPGGQSGEWICSPIKDSWTCGFLVGLLWLVEERKRLMPESVHPSYDSEMLVHLARRWQDAFQCLLDPAPNHDQGFRFQLSHGRDFAMTGSAKAKQTVISAADSLVDRYNPSIGCIRSWESHEVPSLADDPESHFLIIIDTMMNLDLLYQVSEMTFDAKYAAIATRQAEVCMKTHIRPDFTTYHVVDVNPTTGKVQRRFTHQGWKDESTWPRGQAWGIYGFAQCALRTGRQDFLDTSKKLADVFLAKLPPSGVPPWDFDHPRPTPYDASAGCVAARGMQMLYQLLTPEDPKVAERYLAAGFKLVSDILRECYTPEASLVQTDDGLSVNWGKADWEPILAHSTISGDVCGEARQDHGLIYADYYLLEFANEALKMKKGLGFNGFKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8J4</accession>
    <name>A0A1Y2B8J4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_558499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8J4"/>
    <dbReference type="InParanoid" id="A0A1Y2B8J4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013186399" evidence="2">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="211" mass="23108" checksum="DA25D0BD41C8B0CB" modified="2017-08-30" version="1">MRATGMLLTSIAVASSIFAADSIPHVQSEYGSTGSTPRDQIEGSWRAEHCRRTLVDSMFRQQNGLHALKDGRDPIEDTVADEEMQTCKREFPDLDRSVPMTFDEMCRYNELVRDVSVLQWRYGVAAVEKLSKVLSRSSADSIRLSGKEPGSAMEDASQNEGDSDRNDIEASTLDLPQISFATFSGLGNAGPTTCPTATATRWETAALHGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB59</accession>
    <name>A0A1Y2BB59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_597909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB59"/>
    <dbReference type="InParanoid" id="A0A1Y2BB59"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="574" mass="59968" checksum="FBDEC63E0DB42FAF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB95</accession>
    <name>A0A1Y2BB95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_524149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB95"/>
    <dbReference type="InParanoid" id="A0A1Y2BB95"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF23">
        <property type="entry name" value="FLAGELLAR MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1173" mass="125003" checksum="CCB3E2707FF3EDFA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBC2</accession>
    <name>A0A1Y2BBC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_525744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBC2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBC2"/>
    <dbReference type="InParanoid" id="A0A1Y2BBC2"/>
    <dbReference type="OrthoDB" id="2595252at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012011054" evidence="2">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="243" mass="22007" checksum="66E4707415879420" modified="2017-08-30" version="1">MRLSAIALLPLVALTSVLAEPAAAPTPPPIRIGLAGASNKRAQPAGVARRQLGSVLSDVTGGAVSVFSQVTGGAASVGGDITSVGGSVFTEVTSGAGSVFTDVTSGAGSVFTDVTSIGGSVYTIVTSAGGSLATDVTSIGGSVYTVVTSGAASVAGDATSGGASVASAATSVAGAGTSGGASVASAASSAAVAGTSGGASAVSAASSVAASSAGAGIIIPSGTFIGALVGAAGLALGFARVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBF2</accession>
    <name>A0A1Y2BBF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBF2"/>
    <dbReference type="InParanoid" id="A0A1Y2BBF2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="62" mass="7224" checksum="95D6125A1FB213E0" modified="2017-08-30" version="1">MDCLAHDRYVRILVSSLLSVVLFFSRLSVEEFLSSPLSRFDRLLTTYIVRDGHVLCYFCHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBL9</accession>
    <name>A0A1Y2BBL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_557623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBL9"/>
    <dbReference type="FunCoup" id="A0A1Y2BBL9">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBL9"/>
    <dbReference type="InParanoid" id="A0A1Y2BBL9"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="85"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="413" mass="46274" checksum="03F16719AE1D5099" modified="2017-08-30" version="1">MLLSRTLALSQPCSSLQASRQINCLFTCRFITSTSSRSENKSAQPSTAATATANIELSAPVTYLSESHDPYFNLAYEDHLLRSTPHNQPVLFMYRNRPCVVIGRNQNPWKETTPRLLRGESIPLIRRRSGGGTVYHDMGNTNFSIILPRLMFTRAHGAELVARAIREKLGITQCGVNERNDVIIRDDEHEFKVSGSAYKIIQHRAYHHGTMLISSSLSELGKSLKSSSPHIETKGIPSFRSPVTTLNTYLPSSRQGRPIKHDEFVSAVSHEFASVYAGPGKQVITYEVSENLVREVKVWDGVRELKSWEWQYGQTPEFTNRLETVLPFGEISASLTSRHALITSLTFHLTPSISATTAETTVRQEFLDALALSLIGARYEALEGADGPEDPAYDTPQWRELSHEIISWLRQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBM2</accession>
    <name>A0A1Y2BBM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucoronosyl and UDP-glucosyl transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_557870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBM2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBM2"/>
    <dbReference type="InParanoid" id="A0A1Y2BBM2"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55025" checksum="DC59F4DC960EBDFB" modified="2017-08-30" version="1">MPRRPIVLFATSPEHGDSNVHMAVISSLLEKHGDEIEIHLTSQSTLRDRSPPTVTFHPLPWKSIVDNWPDKFDPSRPHLNSMEFVFSPAGFLGSMWGCTKLQRFIHAESPEEYIETAQSAVHLFNTLKPDLVVVGFLAEAVVDAAIKTGQNYIRLSPNTLREVAAGAQGLRAFLWPCAGTGYPFPIPWYLIPLNIINLLFVPIWLFIFDSNFRAKNKARNAAGFSGPMPIFQKSHAPTICMSTPSIDYPAIIPQNVFPCGPIIQASRPLEQVDRDLYDWVMSRPTILICFGSHYPLDEGYGHEVFNAIRLLLDTRKDVQVLWKLRKWTSYDIYTDPVGDRLRVTDWLTANPSAIMATGNVICVVNHGGSNSYHEALFTGIPQVIVSSWYDCHDFAVRAEWLGIGKWGNRAASPRASYRELYKAVLEVIGLTANATYALQILDRAMDISEVAQGRRSAVVTKHGPIVGALDGRKREGRDVAAEVIMEYLAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBR5</accession>
    <name>A0A1Y2BBR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_464909</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBR5"/>
    <dbReference type="FunCoup" id="A0A1Y2BBR5">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBR5"/>
    <dbReference type="InParanoid" id="A0A1Y2BBR5"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="922"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1001"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY32156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1065" mass="116278" checksum="EB7200121B5F2063" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD68</accession>
    <name>A0A1Y2BD68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_504582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY32005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD68"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD68"/>
    <dbReference type="InParanoid" id="A0A1Y2BD68"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="79"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="336" mass="36456" checksum="AD225B2F339D640B" modified="2017-08-30" version="1">MSSHTARNIDENGEPLPFGTPAILAAFGIPPPPKQDPPMREFRGNTLAHPFFMKERMKLSREKPMMGIWYGAFPSIPVARAIGQAGFDFVLLDWEHTPYTIESVGELIKTISYSGEGDSAVIVRVPSHEHSYISWALDAGASAIILPHVRVQLTSYTSADESRQKLSNRQRPPSITYGSPLVLILLQLGGNRSFPPNAMLFGYNDGASGGGGGMEVWNRAAVILQIENELGAENADAMAAIDGADLGLEVGTTLLEMYGNPRWIAAVQKISAAAKKHNKAAFMPALFPQTVELNLNLGFGMLTCTNDGYAFVRALRSELLVGTKALDAWKEKNGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDL8</accession>
    <name>A0A1Y2BDL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_522387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDL8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDL8"/>
    <dbReference type="InParanoid" id="A0A1Y2BDL8"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="91"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY32921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="666" mass="72824" checksum="C82A35C515865FC1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDM6</accession>
    <name>A0A1Y2BDM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_522391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDM6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDM6"/>
    <dbReference type="InParanoid" id="A0A1Y2BDM6"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21986">
        <property type="entry name" value="HMG-box_TFAM_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="219" mass="24397" checksum="0C1D1303511B093C" modified="2017-08-30" version="1">MLGLRSGLNATRAAASGVQVQVMTRAFTASAVSFKSKYPADLPKAPKGPITAFGLFLKKHYADQRATKGDNGEKINVTQVMNEVGDIWKNKLASSEKQTFEAEAAEDKKRYDAEYLQFYESLDKESIRRIKKFTGNSVRKPGGKVAWNQSQRASGLARPNPPYIRYYREFLASSEAQGLPMADSAKKAGANWKSMPDAQKKKYKDEYDAEFAKFKQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDP7</accession>
    <name>A0A1Y2BDP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_557458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDP7"/>
    <dbReference type="InParanoid" id="A0A1Y2BDP7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="214" mass="24131" checksum="BE4AA060B6D1AE2C" modified="2017-08-30" version="1">MLDDVLSHIGPVVSFFLEVESEINLTVSVLTALQEDAKDTVPSILMANTFRTDFQMDTNLAFDRIAPLPKNPARAHNGMYNSQDAASLQLQEIQGNPIHHLRDLAAYHLHNLPAIFDCEAQHRQAIDMWIPTPDDIDKYEDLRESVPNPPQFEQAHSLPPVIPDVSQYYYFGPHSVCFLRVITTPLPMTPVCALYLTAIVATRRDEVRSGLKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDY5</accession>
    <name>A0A1Y2BDY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_520919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDY5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDY5"/>
    <dbReference type="InParanoid" id="A0A1Y2BDY5"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF14">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY PROTEIN 7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118843" description="Short-chain dehydrogenase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39883" checksum="18A15F94A2838FE3" modified="2017-08-30" version="1">MTSKLWLLLALPVLLRLLRVKPKRSREAIIPPRDERVVLLGASSGIGRDLAHAYARRGARICIVARRADALASVKNECIELGLSEDKILLVQADMTSASDLVQLRTEISKAWGGLDTLHILAGVPSTTTLHDLSGVSLSNSASPASTKRIFSSSSFVPTPIDGLPSLDGLENVAKEARACAEINYVGTVLSLACFLPLLASSSISPALHHLSSVAADVPAPVRTIYSATKAAALMAVESCRVECEGCGVRFFSLLPGTIDNGFRLKTSTAQTGGRDELVLPIRHNWERLLLEPSTVIDSILYHLSLNPTPQPLIPIYPLSKITALSQPPKALVHLPWQYRMAFWMRDTPFGWGYLEKNARRKYGLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEE3</accession>
    <name>A0A1Y2BEE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Septin ring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_521401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEE3"/>
    <dbReference type="FunCoup" id="A0A1Y2BEE3">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEE3"/>
    <dbReference type="InParanoid" id="A0A1Y2BEE3"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="90"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="467" mass="52866" checksum="5D6236682AEA7E3E" modified="2017-08-30" version="1">MADSYYDNPPLSAGSGGGSISPNGAYGEERSGGISPNSRATSPNASYANGGTTMSALPATPTPAVQRKVLQSWVGFSNLPNQVHRRSVRRGFQFTAMVVGESGLGKSTLINTLFETKLYAPKEYPPPGVERGKTVQIESISADIEENGVRLKLTIVDTPGFGDYVNNDESWKPIVDNIEARFDAYLEQENRVNRKQLIDNRIHACIYFIQPTGHSLKPIDIEFLRRLHTKVNLIPVIAKADTLTDEEITSFKQRVLADIAHHGIRIFQPPQYENEDEETIQENEEILSKVPFAVVGSDTLVRAADGRQVRGRAYPWGVIEVDNESHCDFVKLRQMLVRTHMEELREHTNDVLYEDYRTDKLRAMGVSQDESVFKETNPAIKQAEERTLHEAKLAKMETEMKMVFQQKVQEKEHKLKQSEEELYARHREMKEALEKQKLELDDKKRRVESGRPLTPEKGSKKRFGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEP5</accession>
    <name>A0A1Y2BEP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_557530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEP5"/>
    <dbReference type="FunCoup" id="A0A1Y2BEP5">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEP5"/>
    <dbReference type="InParanoid" id="A0A1Y2BEP5"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="10">
        <location>
            <begin position="885"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1014" mass="112737" checksum="59BCA4D9B56B9DE6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF21</accession>
    <name>A0A1Y2BF21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein Mis14 like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_519931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF21"/>
    <dbReference type="InParanoid" id="A0A1Y2BF21"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23644" checksum="5B35A540EF680BED" modified="2017-08-30" version="1">MDQPTLSRIAVESQSDWLRVQENIKRGLEQAMEARLGALPGGKDGEAAKRVRKEVEGRLEKIREEMFRLSVPNLRVNGHNYEDFVDATEPFDEMLDRKIKGLDTERVAWGMSVAARRKRTPADIYRLEANLEERREMAEWLPEGEDDEGEQQKRAVDIPKPPRHQETIETFGEVVSNLSQLASMAPKQLARAQRAQSVREEIASIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGN5</accession>
    <name>A0A1Y2BGN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_517941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGN5"/>
    <dbReference type="FunCoup" id="A0A1Y2BGN5">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGN5"/>
    <dbReference type="InParanoid" id="A0A1Y2BGN5"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY33958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="236" mass="25975" checksum="BEB8731F9D230B26" modified="2017-08-30" version="1">MSSKWVPLEASPDVFNQWSRTLGLPSSPLSFQDLWSLDPEFLSFTPKPIKAVLLLFPSRGALHDAREQEEVSGEGKWDGKGVWWIKQTIPNACGSIGLLHALLNLPDSGPYALKADSPLVKFKQASIPLNTVDRAKLLDESTFFSEAHTSAAQTGQSAVPTDLDIDTHFIAFIEAENENGEKRIVELDGGREGPFDRGASNDFLLDTAKVVQEKYFDRAGDDVNFNMIVLAGEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGN8</accession>
    <name>A0A1Y2BGN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_231320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGN8"/>
    <dbReference type="InParanoid" id="A0A1Y2BGN8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010987439" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13457" checksum="E0C3D3B3B5970FB5" modified="2017-08-30" version="1">MGIWACEKRAVVLLVVHTCHSTSYMYLNEVDGNTGSGYPIRQIPLYRFLYLPFCSRNYYFRRYPFELQRNLSSCSLVSHFVGTLRLGVRVKSEQSVCVFTLPWKTEKSGVIYREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGR4</accession>
    <name>A0A1Y2BGR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_556757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGR4"/>
    <dbReference type="FunCoup" id="A0A1Y2BGR4">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGR4"/>
    <dbReference type="InParanoid" id="A0A1Y2BGR4"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="73" mass="7838" checksum="B73F990296734D09" modified="2017-08-30" version="1">MSSASDEARLENARETIDTLHDLSQLLQTGLDKQTLSICVGMIEAGANPDTLAAVIKELRREGQGLQLEQSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGT8</accession>
    <name>A0A1Y2BGT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_463060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGT8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGT8"/>
    <dbReference type="InParanoid" id="A0A1Y2BGT8"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36420" checksum="A60293D84B91C389" modified="2017-08-30" version="1">MTEEAKIRDTEKEDQDDNGNKGNEEVDDELKRQTDFVETFEADYKGKKNGRVIALDFDDVCAQNVLALITEHNVKFGTDLTLNDYQSYIIFQNRGWGPIADVERKLKKLGNLLPKTAPIPGFVPALRALHAMGHPLHIVTARPESDHAAVIEWLAQQGLTVGMGDDDVIAAAWFTDTYGDLGRPDLGERRSTASGVAREQELNEQLKEALRTKTQQGKGGRNKLKVLRAINASLFIDDHHGNLEPILESDPAIPCLLFGPYAWNRSRSGVSTPAELMTFQERQVHGIPLPREPIHVGDNLWRAETWEDVIKWVRRWDELDVVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH39</accession>
    <name>A0A1Y2BH39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_518561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH39"/>
    <dbReference type="FunCoup" id="A0A1Y2BH39">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BH39"/>
    <dbReference type="InParanoid" id="A0A1Y2BH39"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="104"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="308"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="56061" checksum="A441B4B16999FAF7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHD3</accession>
    <name>A0A1Y2BHD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHD3"/>
    <dbReference type="InParanoid" id="A0A1Y2BHD3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14556" checksum="F68E904C63A28D99" modified="2017-08-30" version="1">MVIDFPLDLPYDQSALRNNLESSIRAGKISASEYEACEASARWGWRGMLAGAGISLFLGPIALNRFKVTRANNGLRIASALASVIVGGGSGLMIGGLSAKQKFRDTVSSGNVNQMWDAFEEIKLKSRVHPRRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHG3</accession>
    <name>A0A1Y2BHG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_517047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHG3"/>
    <dbReference type="FunCoup" id="A0A1Y2BHG3">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHG3"/>
    <dbReference type="InParanoid" id="A0A1Y2BHG3"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="213" mass="22695" checksum="C2000AE61D5C0F8F" modified="2017-08-30" version="1">MSKQTILFIFTSADKALDGKPIGWYLPEAAHPYYALVDHFAIDSASPKGGLPPLDHVSVENFKDDESVKFLEKDPAAKKIWSETKKISDVSAADYAAIFVVGGHGPMIDLAVDKDLAKLLQDFYAAKKPIAAVCHGPAALTSATKPGSSESILSGVKVTGFSNSEEAQTPYNDFVNILPFSLEDKLGSLGGKYEKGADWGAYVIVDGIILTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHN5</accession>
    <name>A0A1Y2BHN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alginate lyase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_518209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHN5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHN5"/>
    <dbReference type="InParanoid" id="A0A1Y2BHN5"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012621201" evidence="3">
        <location>
            <begin position="25"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="70"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="454" mass="50037" checksum="C548A1371D4CD739" modified="2017-08-30" version="1">MPSLATILRALTLTLTFLAAPCKAVGITSYANMFFEPSDVINSTWFENSQWAQEMAISWTRKLALNGPWSVTNKTVMAKSGDVHDYLSYAVYYWPNCTSVGNTTALTSEEVWDECPYYRRDGVFNPDIHVVEDNEAMANLTDSVYLAAMAYIGTGDSAYSQHINDAMHTFFVNNATRMNPSIDYSQVIRGPGTQGGRRQGVLDMRGLAKAVSGVLVLRELEAPEWTDETDQGFVQWATDMVTWLETDDLALAEKAASNNHGTFYYNQLCALYALLGENDKAISALNEFYNSTFPGQINANGDQPLETARTRPYHYRAYNLAALTTNARIGDYVGLSPSGWNRTTTSGATMFDALKFAMAQNASTTNEDAEINQLNPTIAAVASKFGDPDGAYAAFLKASDPYYPGQPYFALNAGVSDSGIRQGLLRTTYGAVPAQPTKGSSWGYKRHERSRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIG4</accession>
    <name>A0A1Y2BIG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_513421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIG4"/>
    <dbReference type="FunCoup" id="A0A1Y2BIG4">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIG4"/>
    <dbReference type="InParanoid" id="A0A1Y2BIG4"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="36"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="271" mass="29801" checksum="B252CA237A4E933B" modified="2017-08-30" version="1">MSVHPTTLKTYASRISQHPNPTAKRVLEIMERKKSNLCVSVDVTTADEVLEVIRRVGASVCMVKTHCDIISDFTLEFANELVRLSKELDFVIFEDRKFADIGNTVTLQYSSGTHQISSWSDLTNAHPLPGPGIISGLSSVGKPLGRALLLLAEMSSAGNLATGEYTKQAMKMARDAGREFVVGFIAMGRVDVAEQEDWLIMTPGVGLAAKGDSLGQQYRTPREVVYESGCDVIIVGRGIYGIKGGEEAVKKEAERYREEGWKAYEERLARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIR0</accession>
    <name>A0A1Y2BIR0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_120102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIR0"/>
    <dbReference type="InParanoid" id="A0A1Y2BIR0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="62" mass="6862" checksum="1852758EC0073127" modified="2017-08-30" version="1">MRKVIIRFIVSATSLTSGIDSATSIENFGTDSCEVLHDDRWILEKASLSTLWRGARFTSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJC8</accession>
    <name>A0A1Y2BJC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_516943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJC8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJC8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJC8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="303" mass="33634" checksum="F17442FA6B3E4DAB" modified="2017-08-30" version="1" fragment="single">MAEHHHQDASDSREPDTADHDWHSRVTGSRRPPRSPSPSTTASFSINSSVDFHVFRVDDGRRYQARNDDYTLPADFRELERLDAQHYGFKAAQAGKNYIGPMDEALPNGGAGKRILDIGTGTGIWAVEIAREFPRAEVYGMDLSPVQHDLNLPENVAFLHEDCTKGLPFPNGHFDVIHSRALVAGIRDWRAFISEANRVLAPGGLILCVEMAGLMRIDGIDEEEADAVAPGFMALSREVERSLTIRRLDVNAATKTIEETIATHPELHGFQRVYGPLPLWPWSDDPDMKEAGRVMLSDAQGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJQ2</accession>
    <name>A0A1Y2BJQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJQ2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJQ2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJQ2"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30947" checksum="B9BA35B8A5AEA2F8" modified="2017-08-30" version="1">MSDTSKPTYASTHDHPSHIDLPPAPGGTDIAPAPDDLLSPPVPSSSRPAPARGILKNPLRRPSLLPDDRGMISPQTDMDREKEGERLKWDEENLLETEIQKDSLMKIDEPKTPYVRYDAVNDIVLDDVPDFDLRSERPPPSPLNSLPDSPHTARRSSSSTSSSRSASFSLPTRPHPVRPGQSSSTPPAGTGAFPSISAPIGATQANTAANAGLEVFDDSEEEFMDEEARRRHEQFQKKRGKHYGNEAKIALQKAKELLKQVEAEEEAEGAENGEAPQVVAPNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJY6</accession>
    <name>A0A1Y2BJY6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_477041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJY6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJY6"/>
    <dbReference type="OrthoDB" id="2575102at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31519" checksum="A63C95ABB3557FFC" modified="2017-08-30" version="1">MYSPHQHVQVFVSVYFYVETLCSGLTDLKPEIPLDDMEADLTPPSDMTPQCLRDVTRLEADYMAHLANPYVDTSSPDYIAATEDKWAAMLRNLRLSDNDERSRVKRSWAELRYSWLRILLHARDVSNNLPSSRAGTSLVRSVSQILHIFHDLASFGQFSPSWPQLRMTNICGCLLVLLMAQGELHILEGKNMFEMLLQVLERHHAMWPDSVRLSKGFRQAVRVFNIHFDDPTEPEIIGSDDVPDMWIDLDSTIAQWTAEFLFDFDLSSVEPSDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BK63</accession>
    <name>A0A1Y2BK63_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BK63"/>
    <dbReference type="InParanoid" id="A0A1Y2BK63"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="476" mass="52379" checksum="A6B8DC1252F793EB" modified="2017-08-30" version="1">MAGNSGSGPTSSHHPDPNTSSSERGSPASTSASASSQRESVPGTSSGWRRFRTVLSRPLRTVTTNLTAVLDRRRTHRPPGLPMDTTFLFDASTGSRLSRLGEETLETIQYLLVTRTASFDVRLPSMPNLHTLILDERLAKRSATGTRTGGTDEELPEDGIHEFARSVFDASSIKQLYFYSNKKPSRKPKTLDFCRQILKDASQSAVINKISFFQRTLRSLMFDEDGKPQQPLEIPTSVSQLEFQTERDDIGSVLYDLLYIPTGNALQGGCAPRIVTLFASSVFTRDERGDFAPPSFFEEITAADGTTITAIDGTIHGIPEGQWTLRLSEESMSVAQDGQDDACEMLITPRIEHPGSRTSLKMWRRQLSEQIQNMDRTFWDESDRVRSFLHSRTLESSTGGHVRPLADHATSLISGDSYRANASADSTEQIQEEPVEVGVRGDGDNALLANYVYLLDAQAPGVTGRLIFLGFPPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKE1</accession>
    <name>A0A1Y2BKE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_516673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKE1"/>
    <dbReference type="FunCoup" id="A0A1Y2BKE1">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKE1"/>
    <dbReference type="InParanoid" id="A0A1Y2BKE1"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="566"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1118" mass="124139" checksum="C473D08B84916779" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKU5</accession>
    <name>A0A1Y2BKU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_509168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKU5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKU5"/>
    <dbReference type="InParanoid" id="A0A1Y2BKU5"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF14">
        <property type="entry name" value="ARF-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="383" mass="40312" checksum="E8070A7A728AF06F" modified="2017-08-30" version="1">MSRQDKATTERNARILRELVKQPDNKSCADCRKNDARWASWNLGVYLCIRCSGIHRSMGTHISRVKSIDLDIWTPEQMENIQKWGNRRANLYWERHLKAGHTPPDHKIESFIRSKYESRRWAMSGPPPADPSVLDEGEAQSSAGPAPAQPTSTSSAPPPVPAGRPQTHPLLSRTVPPKAAPAPVATPIVDLIGGDDPAPAPTAAPTQPPAAAPAQATSAAAPPAPTAPSSSIFDLDFRAPAPQATSKPPNAKADIMSLFSASSPSTAVPPSQPFFGVTNSLMPTDAGLASWGGGITSSAPPVQQQPITQAPITNTGWPGMQVDQGAWGAPQQASTAPNANPWGGSSDPWASSGNGSANVQSGLGQVSPEAAKKERDPFANIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL85</accession>
    <name>A0A1Y2BL85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_567766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL85"/>
    <dbReference type="FunCoup" id="A0A1Y2BL85">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL85"/>
    <dbReference type="InParanoid" id="A0A1Y2BL85"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000007">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="110"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="426" mass="47074" checksum="BDC8C874BD6E7D55" modified="2017-08-30" version="1">MAPIATTTLTNTTQETSDRLGQLKLNVANGESSSGKASSSLVDPYNYVGEVLGAGPGPNYPYNDLLPHNPRRSHPDPPLPYYDITDRGHFADPDHSRLRAAVEAKGGRIKDLGICVGTVVEGDVKLEDLSQEARDDLALLVAQRGVVFFRKQHSLTIEDQRALGQHFGPLHTHATYAVPRRGGLDDVVVVYSDRDSRPDLYAFSRAELFHSDVTYEVQPPGATILRLLTTPEVGNDTLWSSGYNVYSQLSRPYQIYLESLSAVHSGFNQAASRTAVTQVPRREPIETIHPVVRVHPVTGLKAVFVNPGFVTRLVGVPKAESDATLEFLKQSFAQQTDATCRWRWETGDVAIWDNRVVNHSATFDAYPSLRHGLRVTPHAEKPLSVEEYEKATGKEAKDWIKERFRALGIDGPAGDDGKTRPKGFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLA6</accession>
    <name>A0A1Y2BLA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_585037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLA6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLA6"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22614" checksum="5234C7828C15DD5C" modified="2017-08-30" version="1">MADSKVTSTELHSSANDPSTLNFAPGLSPTDLQRRHAAIVLDMFQAKGTMAKLRDNFSEDAVYEDLFASCKTREEVGGQLLHLPTICTSATTNSHLITSLNPITTTSGSGRSVPTTEIAIKVDHTFVFKAPLPVSARSITMNTTLLVYSDEQEGKIVRLQDRPMEQIPENALLSWIRRGNAVGVPKVIPLPKDEKEDAEKVLKQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLB7</accession>
    <name>A0A1Y2BLB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_510818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLB7"/>
    <dbReference type="FunCoup" id="A0A1Y2BLB7">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLB7"/>
    <dbReference type="InParanoid" id="A0A1Y2BLB7"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="180"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY35564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="270" mass="30817" checksum="F499D3EEDEA34852" modified="2017-08-30" version="1">MPPTAFLAAPKPVSLHAILDVNNFQSPTPNIDLEWEPFQAHVEAFLNAIDKYTLDAKTEIAARASDHIALVRDMKADKDETERRIQLEREKEGEMLATLEQERHTLQDLTSSLSHLQTTLSKVKDQSATLESELNSVKKEVSTERAEKERQRRKLEEMQEQDEIELGGLEEVLGWRIEGIRENILLMRFTLIDPSDPEREFSLVIDVSKQDYSVPRCEPPLASLPDMLQQLNTDRDLYGFIKRARKAFRALVPSQSGSTKFDDMSGPGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLE7</accession>
    <name>A0A1Y2BLE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nineteen complex-related protein 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_563548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLE7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLE7"/>
    <dbReference type="InParanoid" id="A0A1Y2BLE7"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="818" mass="90436" checksum="8C3C9AD2A9DFB266" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLZ5</accession>
    <name>A0A1Y2BLZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_511855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLZ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLZ5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLZ5"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="72"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="442" mass="49401" checksum="068EA18A43BB9E52" modified="2017-08-30" version="1">MTMASSSVLVGQLKRKYPLPEPDPNWVQECVNALIEDDQNPSFAAVEEQYLYSDLSQSTLASRVLLPSEAHDKILFPSPVLVQLISLTEIGSSAFQLQTVLEQRRDVLEGATRILRMDEEEEQDHGVEEGKLPAYPRGMLQLEISDGRRVMAAMEYRRINGLVLGETALGAKLVLQNVRVLRGTLLLTPDNTNVLGYQVDHLESEQPTRFVNGLLNRLAKHEEHSQAAHHTPRVTATTTSTAERRAAVMRTTIPTQAESSTAAQARARAIATAAATAVPLNPRRQQSPYSPPPIIRPTAHRIASNSAANNTSKRKRTTPQPQSQSQLQLVPRVQDVQAKSKSRTTDTSEYDISAFELDESMLRDMEQIEKQATITQRRAIVVESDEDDDFGVDESFLRHVDDAVAKATQSQTSEWKRGMISDMDEWDDEKENRREVIEILSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM04</accession>
    <name>A0A1Y2BM04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_511584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM04"/>
    <dbReference type="FunCoup" id="A0A1Y2BM04">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM04"/>
    <dbReference type="InParanoid" id="A0A1Y2BM04"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="272" mass="29790" checksum="E7397E7345794B03" modified="2017-08-30" version="1">MTELNLRPVASSSSSTSSSSKPIPTSSLLKPWDFTYSPSQTGKDLNLLIMFHGLGDTKLPFSNLGRQLNLPHTAVLSLQAPNPIPLLENPSYSWYNTFTPLFEPLASPDPTTALPSLRHLLEALTSSQVGWELPQIHLFGWGQGGTMSLELAYNIGREPLDTCTTGAPAKRFGSVISICAPLLSHPTSDLKLETPVLYFTRQSPQSAVGKKNQGVIKRAFKQVDVVVGKDGKGEEMPRGRGEWEGIMRFWAQVLKKDDDGWKGGGQVFEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMA5</accession>
    <name>A0A1Y2BMA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_512886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMA5"/>
    <dbReference type="FunCoup" id="A0A1Y2BMA5">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BMA5"/>
    <dbReference type="InParanoid" id="A0A1Y2BMA5"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="88"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115143" checksum="BFC933FBFA72DAB8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMB9</accession>
    <name>A0A1Y2BMB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_556042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMB9"/>
    <dbReference type="FunCoup" id="A0A1Y2BMB9">
        <property type="interactions" value="635"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BMB9"/>
    <dbReference type="InParanoid" id="A0A1Y2BMB9"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY35918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="605" mass="65271" checksum="739A4D3676D15368" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AD02</accession>
    <name>A0A1Y2AD02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_89615</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="MCFC01000146">
        <property type="protein sequence ID" value="ORY20170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AD02"/>
    <dbReference type="FunCoup" id="A0A1Y2AD02">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AD02"/>
    <dbReference type="InParanoid" id="A0A1Y2AD02"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="281"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="415"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY20170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="694" mass="80535" checksum="24EC5828DE4D1057" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AD56</accession>
    <name>A0A1Y2AD56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_601523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000145">
        <property type="protein sequence ID" value="ORY20197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AD56"/>
    <dbReference type="InParanoid" id="A0A1Y2AD56"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY20197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="243" mass="26802" checksum="F3060E8DC9C62B08" modified="2017-08-30" version="1">MSSNIDYLSIATSILSAPTPPAAIRNRVVRTPVDFDSQPAEGDDEYQPGYYAPGTFVAHVESDREPDRGQYNVLLYRPEVNEPAWFCPPTFLLSTHGYHPQSAPLRPSYLIHAYRLALAVENSLAEPDKHVVAIYDCGEDSGVKIGHKCVRFYIAKGDRVKPRLPSKAYPLPPGLSLDTPAKELADLFQKILQDHVPQSPPYNLYLCRDQAIVVERVAGSDGKLAEYGPGLWDGGRLIGLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEF6</accession>
    <name>A0A1Y2AEF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_74245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000121">
        <property type="protein sequence ID" value="ORY20949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEF6"/>
    <dbReference type="InParanoid" id="A0A1Y2AEF6"/>
    <dbReference type="OrthoDB" id="2564461at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY20949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="682" mass="74615" checksum="0FAD31F7DD22F357" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEZ4</accession>
    <name>A0A1Y2AEZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_554270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000119">
        <property type="protein sequence ID" value="ORY21042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEZ4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEZ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AEZ4"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY21042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="666" mass="72541" checksum="2C4FB59EA0BB73BD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFF9</accession>
    <name>A0A1Y2AFF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cytosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_554335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000120">
        <property type="protein sequence ID" value="ORY20997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFF9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFF9"/>
    <dbReference type="InParanoid" id="A0A1Y2AFF9"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000066">
        <property type="entry name" value="Chromosome 10, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012892265" evidence="3">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY20997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="257" mass="28303" checksum="63F27F50D669069F" modified="2017-08-30" version="1">MRFTITSLALCSVASLVSGYQVEIHPEHQHGLAINDVPAERRMHWMRVANEAVYADGHPCPQAPFGTAIVNTTSDELVCVISNAVGRTGDPTMHGEITAIRHCTDVLTQRGLSPQEILASWKEFSLYTNGEPCPMCASAIRWAGFKEVIYGSSIRTIAENGRNQIYIPSSLVWEKSYSLGHATLMLGNVLTNETDPFFEHQFNESAACPVGCERQVVPGKRVKACSPVDDWQEVVRKAGRGLAAAQSHRQDSRHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFP1</accession>
    <name>A0A1Y2AFP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_64727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000112">
        <property type="protein sequence ID" value="ORY21379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFP1"/>
    <dbReference type="InParanoid" id="A0A1Y2AFP1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="73" mass="7705" checksum="185D21A54C1516A5" modified="2017-08-30" version="1">MSRVKSSVVPVDHLFVTPHPRLCGTGTGSVPPSSALTAGDIIPMCSRLSRIFVSGTPKQATKTLIIQVPVSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGT3</accession>
    <name>A0A1Y2AGT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_554189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000117">
        <property type="protein sequence ID" value="ORY21165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGT3"/>
    <dbReference type="InParanoid" id="A0A1Y2AGT3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012192263" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="121" mass="13712" checksum="2BE849D729E85DC6" modified="2017-08-30" version="1">MSKWLQFLLTIAQQITSELSDETCISYRTMDGSLRATKSLPDWGQTFAKKVAHKLFGDWAVTEDDSGDMKWAYGPPGVQIEDEDDRDPDVAALVWRSRWQLNVEKAVTGFLTLQNKTETSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHG5</accession>
    <name>A0A1Y2AHG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_552301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000099">
        <property type="protein sequence ID" value="ORY22019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHG5"/>
    <dbReference type="FunCoup" id="A0A1Y2AHG5">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AHG5"/>
    <dbReference type="InParanoid" id="A0A1Y2AHG5"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY22019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="494" mass="52730" checksum="BC08FC3A6D6DC7AB" modified="2017-08-30" version="1">MSPIRISDTENRQSKPNDNFTTRSIHIGSEPDGVTGAVVPSLSVATTFKQYGVGHHTGFEYSRTGNPTRNQLEHLLTSLETSSSAQVTDSVDERYDETSGGADSLVFASGSAATATMCAWVSLAVDEGGAGGRDGVNGLGGHVLAVNDVYGGTARYLSRASKGAGLEVTFLDFEAAGEQGIREAIRPDTRLIWLEVPTNPLLLVPPLPLIAEIVASLPAESRPLVLVDTTFLSSFYITPLIPPTPNSLPLGDIVLSSMSKYSGGHSDLILGALTVSSRTVQARPNLLTGLRFLQNSAGAIPSPRDCHLMTRSLKTLSLRMIRHGLNALQIASWLNQQEKVADVRYPGLATDGAFHLVEKLLSPNARKELEFLGWTFPFKPTSGKVVDTVSEGSLAHVRTLGIPFGGIISFRLKDASAEETDRFCSGLRLVILAESLGGVESLIEVPSGMTHSGLPEETRLKLGITPNLIRFSVGIEDADDLIGDLREGLDALHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHQ3</accession>
    <name>A0A1Y2AHQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_552141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000098">
        <property type="protein sequence ID" value="ORY22119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHQ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHQ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AHQ3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="442" mass="46813" checksum="8A373B8D7A2FCA94" modified="2017-08-30" version="1">MSKPNPRLSKGLVRTLAQAPSSASSTHSALQLAPVVSQHSYSTSSSSSSSSTTSSVSNGKYTSLSSSFSTAASNRLSAALSSLSLSPSSSVSLLPTWDSAPFASLGLPDGYITRTGDGVVLPYRSTSRSKRLLSRRTGSSPREYTTATAPVRHQANFDSFGHPTSTSAQTLFFDKSSFPLFGSNSGTLHDLSQPSDLISSPTPPPEKPARHYLLSPYTSNDSPTSFSIALNPYLAYPQVDPSPIPPPPTSTDATSLNLYSSNLVFHLGASGLAKDRPPSPRNPPSARTPAPPPRARSFPLPKVTPPTTLRSTGVGEDAYFTRMDGMCIADGVGGWARSGRGDADAGRWSRLLTHFCEVEVGSWWAGDPAYLVNGGADATSDAPKSDKADDRGPSGWARKVWQRGAKESDEGRKRRPLDPVEIMQRGFEKCLSCVTAEVSSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHU2</accession>
    <name>A0A1Y2AHU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_584629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHU2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHU2"/>
    <dbReference type="InParanoid" id="A0A1Y2AHU2"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY22173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="492" mass="55631" checksum="BA34BCA728E2E2A9" modified="2017-08-30" version="1">MQYAYYNGDNGVGPNVYSATLFQNFLTKAGHDPVTGESCGTGQCVINLGGQKTVASVALIANGISFAIMTVFFTTIGSCADYGIWNKWILIIATVISWAAQYGFLGITMSSQWRAAMALYIISYITYGVTLVFYASVFPRLARNTQTTKDARGALGRGECTPEEYEHVEMMERNRLSVISTAHSNWGYIVTLCLNLSLLLPLAEDPMVDNYTLAFSNSYWVVLGLPWFFLQKDRRGAPFPKGSHWFTIGWKQIFGAIRHFKRLPYTFIYLVAFFLLADGLNTTGSVIGIVQNQHIQFSFLQSTYLNLANATTSTLSCYVFWYIQKWRKWPTKHLFVVTNVFTVFIAFWGMLGLWTNKVGFHNTWEFWFYNVMFGLFQAPYYAYAQTMMSELTPPGYEGMFFGLFGITNRVSSLVGPNVCSAIINRTGNNWSAFIFLFVDCLLAATVIWFFVDVRKGRAQAIAFSIEERGLNGEVRVEQVEKILLKEKAVQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIZ0</accession>
    <name>A0A1Y2AIZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_551428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIZ0"/>
    <dbReference type="InParanoid" id="A0A1Y2AIZ0"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="15"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="488" mass="52630" checksum="4EB29DB60E366A46" modified="2017-08-30" version="1">MAELTADSSKVVRSVFFALILDLLAFTLPLPLFPRLIAWYLHREAHSPTTLLARLLNLSHTWRASLQSISSPSYRTSVGDETKSLWTAGREGGDAKNWDIVLLGGAMGSLFSLCQCVISPWLGGLSDRYGRKKVLLATMVGNLVSAAIWVQSTSFSSFLLSRLVGGLSEGNVQLSTAIIGDVTTPATRSKSLALIGIAFSICFTLGPSIGAYFASRPLPITSANDDKLNVYALPATISLILLAIETIYLAVRLPETKNLKSQAKSDDKVANIAKEPVSVRKARLDAIGRFHGLFLLFFSGAEFTLTFLTYDLFAATNSQNGRLLSYIGILSALLQARHVRPSLARKGELRVASYGIITCCIGLGMLAILPFSSIKSSQFLSTAVLYIAATGLSYTSATVVTGLTAAAAACCDEEVPGTESLLRRGKAMGQFRSKGQLGRAVGPLLASSIYWLQGPTICYSMCMAFMMGVYVYIQQQVRQEKVRKSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ29</accession>
    <name>A0A1Y2AJ29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_382521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ29"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ29"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ29"/>
    <dbReference type="OrthoDB" id="2564267at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1049" mass="114427" checksum="C6BCC271A1FCBF0B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJS6</accession>
    <name>A0A1Y2AJS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter type 1, transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_369760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJS6"/>
    <dbReference type="InParanoid" id="A0A1Y2AJS6"/>
    <dbReference type="OrthoDB" id="2563870at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="752"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="888"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="977"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="77"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="462"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="753"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1067"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY22828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1314" mass="143807" checksum="9AA7D15532832F9C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALC1</accession>
    <name>A0A1Y2ALC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.137</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_473496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALC1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALC1"/>
    <dbReference type="InParanoid" id="A0A1Y2ALC1"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="110"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY23070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="396" mass="44618" checksum="68E28CFB5D6CF10B" modified="2017-08-30" version="1" fragment="single">LGTTLHWYLMIECDSRLPAGKMYAKVAFRFQKKLQEISDGAAQRDVLKRQGELVEALSVRAREIRASKDARSKKIEKLRSYISDPKHGLCPLPAPLPLPLDARIQVTSITAEKSSVFKSNLFPLLLWFETTEKPPEEDVTIVNPDYPIIFKNGDDLRQDQLVIQLFTLMDRLLRRENLDLRLSPYSVLATSATEGMIQFVPSKSLAAIMAEHGSLQNYLRVDHADDGALGSFGIEAGVLDTFVRSCAGYSVLTYVLGVGDRHLDNLMLSPDGHFFHVDFGYILGRDPKPYPPPVKVCKEMVDAMGGTSSAHYARFQSLCYTAFMCLRKNANLILNLVALMVDAGIQDIQLEPDKAVWKVQEKFMLDLSEEDAIKQFEVLLNDTSYLTVVFDRIHDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALG8</accession>
    <name>A0A1Y2ALG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rrp15p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_549971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALG8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALG8"/>
    <dbReference type="InParanoid" id="A0A1Y2ALG8"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="289" mass="30779" checksum="0DDFE4ADCC530F15" modified="2017-08-30" version="1">MSAPKSILKNKTAGPGPSAIAAGPSRLTGSKLRQSITAPRTSAKKSSKRQEVDSDEDGSDEGMSDAEGEEGEGDEEIGTDEEIEIAKRGGERDKSGQKRKRPTTASEFGTTLTSLLAPTTVEPSVASKKSKKSKTQSTAQTQSTSEAQSTKQAQTAILSLSRAKPPPSAAADKLARLAEKRLKVQKAEKEDHARVRDVVEGWSVDERLSMGGMEFERSLRKTAQRGVLKLFNAILVASKNAEAATTSLSAKAGVRDEAAKRKEKDNVLGRGGKEAALTKESFLDLVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMB1</accession>
    <name>A0A1Y2AMB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_590872</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMB1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMB1"/>
    <dbReference type="InParanoid" id="A0A1Y2AMB1"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="256"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY23691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="572" mass="62730" checksum="F3A0585201128684" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANR6</accession>
    <name>A0A1Y2ANR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_507567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANR6"/>
    <dbReference type="InParanoid" id="A0A1Y2ANR6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="176" mass="18266" checksum="DB1B822EE47931A8" modified="2017-08-30" version="1">MAAIINIDSESETTSTVEHETISIPTETNTNTQTAIAIEAAATTAAEVTSTTKETTTTSLTNTNTQAPATSSDTLGIVGGSEQALHECTGGGGDCEAAVEKNRIAIGVTEEGSQDQPLFDDGASSLNECGVDDVGVEQINLGRKEEVVVVVVVAVKMKIEYEMGRRAESCRILSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APS9</accession>
    <name>A0A1Y2APS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme-containing dehydratase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_546787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APS9"/>
    <dbReference type="STRING" id="71784.A0A1Y2APS9"/>
    <dbReference type="InParanoid" id="A0A1Y2APS9"/>
    <dbReference type="OrthoDB" id="3359285at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025702">
        <property type="entry name" value="OXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13816">
        <property type="entry name" value="Dehydratase_hem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="363" mass="41520" checksum="1DEA20FB83ED5F2E" modified="2017-08-30" version="1">MPPISKLLPHAPPGAYTTTARITPLRKPPGFTPTVQRWSALLPESELYVGFFGVQSEDNGVDYSSPFHTWVKTNLLEHVHGPSTHDYAQFTDQAGHTNHVVSAYWVHQTSFSAWRSDMEVEGFWASPELETSRYGHWREILRVPADRFETIYWLDYQRALSADANVQLYPTPFCGYYGAMRDRIPLSAVDKLDPGPVASPILKGRDTTRSRWRVRPPNNLAVIRSAYSWGLMDEEQKLDFDHKLAPPLARGMTFLKENADTSGCISIRTQITTDAQGHDEPEAHVTAYFLSLDYMERWSEMHKTHAAIFGAAMQRYRHYGDRNQLRTWHEVFVLPDDREQLFEYTNCHSGTGLLAQFQGERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ71</accession>
    <name>A0A1Y2AQ71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynamitin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_546238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ71"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQ71"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ71"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="370"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY24691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="46898" checksum="BF3EEA2CBBFB1B71" modified="2017-08-30" version="1">MSSKYHNLPDIDTAADVFETADEPEQILRPSENILGDEEGPVKVVSENIDSSTLPGRRKIDKVFGRRTRKHDSSYPSFRPRLPPLSRHASTSESDSDSSSPSLPPTARLRETPAARLKRLKLELEEVEMEIQAGPSTLPPQSNEAKRKSVLPKKEPVDLMGELVGLRERLEGVRLDGVTVHNGVIEGGDLREKLDQLGARRIGQGEAGKDADVTREAAIASEPPKSGQLSDIDTRLAQLEALIGPSERSSDSAQPPLLSALGKLDHLLSLLTQPRHLDAISRRLKLLLVDLDRAAAASRRPAGSANLSSVNPPPGGEKPASGTLSQADHANLQSLFALLPRLDPLIPIVPPLLARLRSLAILHTEAGAIVDDLKTTRAEEKREAEEIKELQEVVERVDTGLSEAAKAIKRNWEGLEERLSGLEERIKALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQT6</accession>
    <name>A0A1Y2AQT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_547464</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24315.1"/>
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        <property type="match status" value="4"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
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    <sequence length="2065" mass="231696" checksum="1DC2C575E4E9885E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQV0</accession>
    <name>A0A1Y2AQV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_499907</name>
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    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="term" value="P:glucan catabolic process"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="Glyco_hydro_5"/>
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        <property type="entry name" value="Glycosyl_hydrolase_5"/>
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        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
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    </dbReference>
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        <property type="entry name" value="PUTATIVE-RELATED"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
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    <sequence length="474" mass="54950" checksum="3CDDE60B1293F589" modified="2017-08-30" version="1">MPSVPLKCKGDKIVDGDENVITLRGACLGAYLLQENFTNGYPGHEKAYRAAMLKVLGQEKYDFFWNKFYEYFYDAPDAKWFASLGLNMQRLAINYRHLNDDLDPYVIKEEGFKWIDRVVELNAAEGIYTIIDLHAAPGGQNFDWHSDNNTPVALLWEYKEFQDRTVRIWEAIAKHYKGHPWVAGYNLLNEPTDEAPGAARLLSFYKRLADAIRAIDPDHILCFDGNTFGADFRSFDKAGFDYPNSIFSCHDYSMFGFPIGMHFEGTDENRAKVRDDYERKVEFSKKTNSPIWNGEFGVVYATETSEGPDFEAINEKRYGALSEQLKVYGEDKISWTIWLYKDVGVQGMVYAKPDSAWNTTFKERIEKKRKHALEFWGTDDTATTKAFQPVLDWITETFPEAIPKYPGFWQLKQHLFRRTIYTWISDNLNPWFCEPLKDMSFEDLDKLAASFKFENCQKREKLIEVMTKGAGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQY6</accession>
    <name>A0A1Y2AQY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">4'-phosphopantetheinyl transferase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_545373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQY6"/>
    <dbReference type="FunCoup" id="A0A1Y2AQY6">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQY6"/>
    <dbReference type="InParanoid" id="A0A1Y2AQY6"/>
    <dbReference type="OrthoDB" id="15433at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="133" mass="14631" checksum="6DA8609EE276B56A" modified="2017-08-30" version="1">MILGIGIDILSIHRLESVIRRRGARSLARRICSPTELDSFPLSNLKDQVRFLATRWTLKEAAYKSLPPNLQHGITWSTFNIIHHPTGSPLLAFQDSEKTEHLSPRGVGAAFLCSLSHDADVCVGVVIAQSGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR91</accession>
    <name>A0A1Y2AR91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_546762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR91"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR91"/>
    <dbReference type="InParanoid" id="A0A1Y2AR91"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="580" mass="63758" checksum="56A8A518C7578DD7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASW8</accession>
    <name>A0A1Y2ASW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_560978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASW8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASW8"/>
    <dbReference type="InParanoid" id="A0A1Y2ASW8"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="163" mass="18265" checksum="BE19977EC364C0FC" modified="2017-08-30" version="1">MATPKVRAATEASMSDLAPHLPRTSKLPDGTSYTLRLTPTSRLGNRLRNALYDLFNTNMSSLSKGTSMAYTATSKQEEMFDPSTRFLLVLRTESDSDIMMMPLPMPGALPMTSTRKGNGKGKERAEKQVEVEVEREEDLLGFLSFRFDTEETLGSRDAEVIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATF6</accession>
    <name>A0A1Y2ATF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_280931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATF6"/>
    <dbReference type="InParanoid" id="A0A1Y2ATF6"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="56018" checksum="D78188406DD64F82" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATM7</accession>
    <name>A0A1Y2ATM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF423-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_275431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATM7"/>
    <dbReference type="FunCoup" id="A0A1Y2ATM7">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2ATM7"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13086" checksum="3AC4FEB1058C7A9F" modified="2017-08-30" version="1">MNAATVWKSGALLTATGMSLGAFGAHGLRARYPTLPDRAHTSWSTASQYLIYNGLAMLAISFHPGLLSGIRKYRVASGMILGGVLTFSGTIFGLVLARDKVGKVFGPLTPIGGMIMIAGYIVLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATP7</accession>
    <name>A0A1Y2ATP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="13">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_542581</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="13"/>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATP7"/>
    <dbReference type="FunCoup" id="A0A1Y2ATP7">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATP7"/>
    <dbReference type="InParanoid" id="A0A1Y2ATP7"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 13" id="KW-0288">FMN</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="14">
        <location>
            <begin position="372"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY25921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="500" mass="54716" checksum="992F3ADF4FD0178E" modified="2017-08-30" version="1">MIPSTSRLVRPVVRSLRASTSQSRSLATVSDPPVRHYGGLKDQDRIFTNLFCRHDHGLKGAQSRGDWHKTKEILLKGDSWIIQTIKDSGLRGRGGAGFPSGLKWSFMNKPGWEKDPRPRYLVVNADEGEPGTCKDREIMRGDPHKLVEGCLVAGRAMNATAAYIYIRGEFYQEASHVQQAIDEAYKAGLIGKNACGSGYDFDVYLHRGAGAYICGEETALIESLEGKQGKPRLKPPFPADVGLFGCPSTVANVETVAVAPTIARRGGAWFAGFGRERNSGTKLFCVSGHVNNPCTVEEEMSIPLQELLEKHCGGVRGGWQNLKGIIPGGCSVPVIPREVCEKALMDYDSLKDCQTSLGTGAVIVMDQSTDMISAIARFAKFYKHESCGQCTPCREGTTWMMNMMDRMVEGRAQEREIDMLLELTKQVEGHTICALGDAAAWPIQGLMRHFRPEVEARLAQFHAQHGNVLFGGKLQSEIDSRFAIPDNLGGDATRTIAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATU0</accession>
    <name>A0A1Y2ATU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATU0"/>
    <dbReference type="InParanoid" id="A0A1Y2ATU0"/>
    <dbReference type="OrthoDB" id="2573545at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="478" mass="52333" checksum="38C8844E88DC902C" modified="2017-08-30" version="1">MSTMAQAVYLPPPSLPLIPSSPDPTPLRTIAFSVAEAALQPDPNSPSFTSSLSRFPTTDDMFASSSEDIQGWTAPWSKIERRPSLSRQRSGETIWSVVDAATERREHRKAGHAFQRSSTLPPSPPISPLSYAFVLPSGCRLAASIASTSHPSNISVSSDSRFSLFTRSAEPSPTHSTFAGLDQSRPPPEFVPRLSAQEFAKPQGPPKHTRTKSDLMQHKLPPVSPTRQTTKLPSLAQIQAKMSKGHRRGASVGSVPQIQPRKKMVMRTDSQESVEVLQTPTDEHGPTRREPRIVFSGPHDPRPPTPPSPVGKEPRLAPFLRQRTSGRLASGARSVRSIPSPEGPMLKVTPPTLESLPRFTSPVSYFQAPRTPSPTLKQFNLMVSTPPPRRPTSPLSNSPSSPTGSMRSSSTASPTLSVPIITCTPASERVLRDGIEHESDEDDVVVFDGEAESSKDREERERRGKEMKDRLLQRRRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU26</accession>
    <name>A0A1Y2AU26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_542409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU26"/>
    <dbReference type="FunCoup" id="A0A1Y2AU26">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AU26"/>
    <dbReference type="InParanoid" id="A0A1Y2AU26"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="124"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="364"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY26051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="566" mass="61447" checksum="EFB1990421FEC31D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUP2</accession>
    <name>A0A1Y2AUP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LUC7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_566030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUP2"/>
    <dbReference type="FunCoup" id="A0A1Y2AUP2">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUP2"/>
    <dbReference type="InParanoid" id="A0A1Y2AUP2"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46153" checksum="5A2607DB720C72B5" modified="2017-08-30" version="1">MGKMAEAQHKLLEQMMGAEAMGGKVEHLDWWSEKVCRNFLFGACPHVLFGNTKMDLGPCPKTHSEKILEQFREAQAANPNDPRFAAYKQQHENHLLGLIDDVDRRIRASQRKLEKTPEENRKTIDLMREIGEIELSIQGGTDEIEALGEAGKVEESMEKLAAVDALKQLKADKERELQNLNENAGASGHQKLRVCETCGAMLSVLDSDKRLADHFGGKMHLGYHEIRQVLAKLGEERMLARNGYGGGAPQQAQPPPNAPSAPSGPRGSNVFAPPPPQLTPAKNEAVPHTPLGPRVPPPEEMPAVGHGDKVKREAGELVEDIKEERAREYDQERSRDSRERDRPRESRYRDREGESRDGERERHRERNRDRDGEDKYERSSKYDDRDRRDHDRKRERSRSPAKRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUX8</accession>
    <name>A0A1Y2AUX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_541450</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUX8"/>
    <dbReference type="FunCoup" id="A0A1Y2AUX8">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUX8"/>
    <dbReference type="InParanoid" id="A0A1Y2AUX8"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="233"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="567"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY26352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="761" mass="81294" checksum="4EB8F05E27DA8128" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW07</accession>
    <name>A0A1Y2AW07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_498083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW07"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW07"/>
    <dbReference type="InParanoid" id="A0A1Y2AW07"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="183" mass="19766" checksum="E88F15E18FD18537" modified="2017-08-30" version="1">MGVTFSTLWSKLFLKKETKVLILGLDNAGKSTILYRITMGSVVASAPTVGSNHEIYDYKGVRFGLIDIGGQTALRSSWSQYFAGTAAIILVIDSSDTARLSLAKAELQKLVTDEDLQTSLLLVLANKQDLPAAEGRLTPAQVSEALGLTDLREREWQIMGCSALTGIGLFEGMDWLVGKLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWM9</accession>
    <name>A0A1Y2AWM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_589425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY27003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWM9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWM9"/>
    <dbReference type="InParanoid" id="A0A1Y2AWM9"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="75"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="253"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4387" evidence="2">
        <location>
            <begin position="514"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="618" mass="67977" checksum="2FB8667DFDBD83F0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX97</accession>
    <name>A0A1Y2AX97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_483792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX97"/>
    <dbReference type="FunCoup" id="A0A1Y2AX97">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AX97"/>
    <dbReference type="InParanoid" id="A0A1Y2AX97"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY27213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="511" mass="54145" checksum="C26A84B0FCFCFBE5" modified="2017-08-30" version="1">MSAPSGIKVPDDLKTAFSTAQADASDVRALVFVIQGESFKHITTVKPKGDYKEDTTLLAETLPNPKTPASFAYRLDSKELGKFEWMMVTYVPDDAAVRAKMLQASSRAGLLKALGANNFKHDWFATSTKDLTPAALSAYLKHLASPPPLSAAEAALAEVREAEAAEAKRVALDPEAESRRKRAVVGLAGKFSWGDGVQDALDKVALCSDDGWIVCLEIPTGNTSAISLIRSEACTPSHLASKLPDKSPCYTFYSYPTPAPPPQASIPTHVSSAPISSPRNTFQASQGGVRVVQAGNAPPVEEEKKEDEPDKENDKESVETPDVNDLEIKEAEQEPEKPAAVPDKPVGKGRVIFIYTCPSSSPIKSRMVYSSGVRSVQQDASDKADVEIATKLETSDISDLTESYLKSSLGPAKPSHSSSLPTQKTTSSSLSQAPAFGGAFGRPRPSPSLQPVRSATQVPLPASTGPSTPVSATPGEDEDSKEGIRRAFDAFGPRVGGGGGGFARPRPAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY52</accession>
    <name>A0A1Y2AY52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_469318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY52"/>
    <dbReference type="InParanoid" id="A0A1Y2AY52"/>
    <dbReference type="OrthoDB" id="2572232at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="266" mass="28839" checksum="1E74AA3C7919209F" modified="2017-08-30" version="1">MSSTSSIPSSTSSSPAASTSASGDLAGPASFYKNLFYILIGLLCAFALVSFLSLLRARKRRRQIITEAERLGVLVPGIPGYIPVRERTTLSWAKSDGTQSPDWWDVASPEESHSAHNESLLHPINGMAFGPDFVRQALTIFSFLFPFSIPSVRNHSSFTPLAIIPPKTETGTPDPAPVSALPFFPNHLAYRPESLLPPPPRFTADRPGTLDGLEGECVDVVTLIRMPMQDWAGGKSNPEGEEVTKLWGGAEIGITRLDVQSEYRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ40</accession>
    <name>A0A1Y2AZ40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF885 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_243046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ40"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ40"/>
    <dbReference type="OrthoDB" id="5959877at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57771" checksum="51D255D0336ACE10" modified="2017-08-30" version="1" fragment="single">WIDVLGQLDKIDPKTLSSGEQVNYGVYRAQIEVLIDQQRFKDYEKPLNADSSFWSNHAGTARQPFDGRDDYANYIAQLKQVPRYFGEQIDNMRSGVKRGFTPPKITLQGRDSSIASIADAKTAEETIYYEPFKKMPASIPSSEQADLQSRGVEVIAESILPTYRTLLAFFREEYFPNTRETLAAESLPDGKAYYLAKIKEFTTEDLRPEAIHKIGVDEVARIHLEMLDTVKASGFKGDFQSFLQFLRTDPQFYAKTPEQLLKEAAWIAKEFDGVSDKYFGHLPRQRFAIQPVPDDQAPFYTSGRGGPGVYLVNTYDLPSRALYSLPALTLHESAPGHAFQMPLALEHKDLPPFRAVYISAYGEGWALYCEYLGTEMGIYHTSFEIFGMLSYQAWRAARLVVDSGIHSLGWTREQGQKYLHDNTALSDHEIETEVDRYIAWPGQSLSYYLGELAILKCRRKAEGALGDRFNIRAFHDAVLQTGSVPLPLLERRIDEFIASGGIGPYPDEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZL9</accession>
    <name>A0A1Y2AZL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_588919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZL9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZL9"/>
    <dbReference type="InParanoid" id="A0A1Y2AZL9"/>
    <dbReference type="OrthoDB" id="3251871at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="533" mass="59927" checksum="BB39CCA0A57A061E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B014</accession>
    <name>A0A1Y2B014_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_535825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B014"/>
    <dbReference type="STRING" id="71784.A0A1Y2B014"/>
    <dbReference type="InParanoid" id="A0A1Y2B014"/>
    <dbReference type="OrthoDB" id="2560085at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012146757" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24447" checksum="52C7DF7BFF82A066" modified="2017-08-30" version="1">MVVPRAIHSVLFFISFALATIVLAACSNALASKNRDFHHAKALVAAEGVKLSLSSIKLDAPGYALSVGAGSILINSLLLFFHTLNIMPMPLWQRRIFFLNPLFHVIGTLLSLAAGIAVLKVARHGMLSASATINGVPIPQSVLQAQSASVGLTPEFWAKGYVRFMAISTWPMLPFAVIATYLSIQYYKQERPAAYHARQLDAQAQGQGRMRAVSDAGEKGEVTQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0B7</accession>
    <name>A0A1Y2B0B7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_536071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0B7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0B7"/>
    <dbReference type="InParanoid" id="A0A1Y2B0B7"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="529" mass="58855" checksum="736B21D82D0D27B0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0F3</accession>
    <name>A0A1Y2B0F3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_535500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0F3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0F3"/>
    <dbReference type="InParanoid" id="A0A1Y2B0F3"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="237" mass="26186" checksum="B5F6B957D038B649" modified="2017-08-30" version="1">MPPPEVTIYVTSLTSQPKVRQHIELLRRSLKGLEIPFQEYDLVNEPEAKTRWQRAKPAGQVIGLPGYLVGGEFIGTMDDFEYAVESQTLPTFLRQDQETATLGGSTGEEELERLMREMSTGDLDDLAGQLGIEDQVIGKVGLLVPEKEESKVEEKKEGNAEEKEGEGGKEDVQETATDDLSESKIIGAVLSSGEESVEAEAKVEEKEEEKEEVEKISNADEGDASDKTKNEIKEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0N7</accession>
    <name>A0A1Y2B0N7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_536418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0N7"/>
    <dbReference type="FunCoup" id="A0A1Y2B0N7">
        <property type="interactions" value="551"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0N7"/>
    <dbReference type="InParanoid" id="A0A1Y2B0N7"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="2">
        <location>
            <begin position="121"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="3">
        <location>
            <begin position="382"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="460" mass="50765" checksum="6DA07C17D61D7024" modified="2017-08-30" version="1">MSELTELFQFLDSPNPAARHLALTNLVGHTPKNAPQRHIFIPSSLAGSATNGGGLLPEKRKAGQEEDEQKIKVITDLAALCRDQAFIAHDALSALINLTDSLAVAKHLVDREYLIWLISYTANTTSPLSPLTAMLLSNLTSHASLIPLLTPLTIPIIPLSKSKHYPPYFLPATASASSTIHPDWRDPAFGINLEAGQEDEREIEGIRALVQAFEDGAGEGVKEGKGKRKGECHFLASVFANISMLPSTRQVLLIPRPSFPQPSSAAPSEDDEPLLAKIVVYTEHPDTIRRGGALGCIKNSAMDRASMPWLLASENDRVRLPSDPSRRVKGVDVLPWVLSPIMGPEEYDIDEMEQLPATLQFLPSTKEREKDPVLRMMCIEILLLLSTTYTGRQVLRNRGAYYVVRELHKVEEDQAIRDAIERLVGLLQGEEGRDTLGDHIEELVPAQQLQEVTERDVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1G2</accession>
    <name>A0A1Y2B1G2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative glycerophosphoinositol permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_534603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1G2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1G2"/>
    <dbReference type="InParanoid" id="A0A1Y2B1G2"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="56427" checksum="FA2809EBA7C2A2F2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1L7</accession>
    <name>A0A1Y2B1L7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_534564</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1L7"/>
    <dbReference type="FunCoup" id="A0A1Y2B1L7">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1L7"/>
    <dbReference type="InParanoid" id="A0A1Y2B1L7"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY28634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="515" mass="57671" checksum="0D65D575887C072B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1T7</accession>
    <name>A0A1Y2B1T7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="9" type="ORF">BCR39DRAFT_533839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1T7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1T7"/>
    <dbReference type="InParanoid" id="A0A1Y2B1T7"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="240" mass="26871" checksum="B8F87A3C67999E46" modified="2017-08-30" version="1">MTYTLPSQISSQPLRTQLLTNLATQHSHLLDLFTQLSTPTSSIASSSSFQHPINQLYSLLSEKTTELAYLVEETERHQAAWRELERKKKEVVELEGNVRALISTLEQGRRELQVLVDKGREIIQRVDEVEQRPLQVEPLLAHALALGNTTSAPVSSLIAPVDLAQHKPWPTEMSMRMGILFKSAGSMSGMGDTGLIGDERKEVEKAVADRYDGHREETDRVADRHAVFNLDLNSDDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1Z0</accession>
    <name>A0A1Y2B1Z0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_505766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1Z0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1Z0"/>
    <dbReference type="InParanoid" id="A0A1Y2B1Z0"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="763" mass="81098" checksum="9D9F26F630C81792" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B213</accession>
    <name>A0A1Y2B213_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_533823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B213"/>
    <dbReference type="FunCoup" id="A0A1Y2B213">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B213"/>
    <dbReference type="InParanoid" id="A0A1Y2B213"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="343" mass="37390" checksum="8F0247298BB3EDD4" modified="2017-08-30" version="1">MWRFLKSGFGSSVVFIVQPYRVVMAPSRGSADSLEYPQNLVQTLDAHQGPVYVVRYNHGAKYCLSGSADRSIRLWNPIAGKEIKCYNGHAKEVLALDIAHDNAKFASCGGDKMVLVWDVASGQVLRRLQGHFGKINAVAFNKDAQVLASAGFDAKIMLWDMRAATRDPIQTLKESTNSITSLSIPSDLPEIISGSLDGHLRTHDLRMGKMTEDLVGSPIVSVQASPTAPKDTILVSSMDGKLRVFDRSDGNVLQTFSGHKVKEVRSRACWGYGEGLVLAGDEEGKIWSWNVLDGKPIDPTPMAVHKKPITWLELAPNGKSMVSASADGTIKVWSKSPPVETQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2D5</accession>
    <name>A0A1Y2B2D5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydantoinase B/oxoprolinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_533503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2B2D5">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2D5"/>
    <dbReference type="InParanoid" id="A0A1Y2B2D5"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="248"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="668"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="752"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1318" mass="143124" checksum="BFF9CFA714C8E000" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2M4</accession>
    <name>A0A1Y2B2M4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60s acidic ribosomal protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_533986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2M4"/>
    <dbReference type="FunCoup" id="A0A1Y2B2M4">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2M4"/>
    <dbReference type="InParanoid" id="A0A1Y2B2M4"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="114" mass="11335" checksum="5295CD71CC5F4E45" modified="2017-08-30" version="1">MKHLAAYLLLQIGGNASPSASDIKGLLETVGAEADDAQLDKLLSELEGKDINELIAEGNSKLASVPSGGAGASSGGAAPAAAAASGGAAEETKEEAKEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3G1</accession>
    <name>A0A1Y2B3G1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_175626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3G1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3G1"/>
    <dbReference type="InParanoid" id="A0A1Y2B3G1"/>
    <dbReference type="OrthoDB" id="6088208at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="61811" checksum="6DBD6E2F19784E3B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3U9</accession>
    <name>A0A1Y2B3U9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_169420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3U9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3U9"/>
    <dbReference type="InParanoid" id="A0A1Y2B3U9"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15002" checksum="5D8F2C092781127E" modified="2017-08-30" version="1">MSDRDLEAGGPASVVTDDRKLENSADMDIPSATATLATSTTDLPVSATPPQFHELKPTLTSRSARAAQHTLETFQTSPHNPRNWSSSKKWRVTLTVALTGFISTCGSSIGVPGIHAVMDEFGVTNEKIGVLLTTFYVLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3Y3</accession>
    <name>A0A1Y2B3Y3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_481674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3Y3"/>
    <dbReference type="InParanoid" id="A0A1Y2B3Y3"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="211"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="42371" checksum="771464D2550F2963" modified="2017-08-30" version="1">MPIAVPQLYEYNHVPETKEDLDWADLPTIDLSKFGTPEGNAELSQTLIEAIRTKGFFYVVGYDISQERVNRQFALGQRFYELPLEEKLKYTPDLENGEYNGYRPAGRRLLAGGLPDQTEVYNIPKFNGFFPQEFPDLIKDNQPEIEQFARDLHDKILDPLHDLISLALELPQDFFRNLHKYQNKSEDHLRYMKYSKFTPEQQELLLSHDGLYSQGHTDLGTITLLFRQPVAALQIKDHKTGEWKWAKPLDGSLTVNTCDALSFLTGNYVKSTVHRVHLPPKDQRGVDRLGLLYFARPQNDLKLSTVDSPVLKREGFTQNEFEREGVEVPTMGEFVVRKQTWQQTKRSQYKALDGVEILPGFKGTYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4W7</accession>
    <name>A0A1Y2B4W7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar import and degradation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_531011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4W7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4W7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4W7"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="449" mass="49807" checksum="18992D01FE305800" modified="2017-08-30" version="1">MPTESAPPPERPTNPSYPSQHEVIKCSLCGAGGFSSSSNTNRNTSGVVVLSEPIERICGSCVRAQENNAEWHSPDLDHPEPENTNVNVGLGLRDVQLQDVFATSFTEAIAIPTTPTISQPPRSFQVQSLPTQHTRPWTTANVNQTQAPVSPVLEIRTPSPAPQTQIKEDAERPPNPLLDVTKMRVPSVGRGALYPGSVFKGTQTSGRSAYEVEVRFQDVSIPDSTLCGYLSISHLTDAHPHLTTFFTADIIGPKHGFITGSRFGATEHDDMRHWGRFEQFRRPATRADMIRPELLFRDPLPDRSRGESRGKERDFVFLRIKERFLVPDHTVRDISGASFAGFYYALVDLSPSQASSEPPSTPTSPSVPKAPLSPTLSRRMSSTSDARSSSVRPEGRRRRESTSRLDEPREGRGEATIRGYYFHSLNQEPFQELFLTHVPTKSSSTFEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4Z0</accession>
    <name>A0A1Y2B4Z0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_532969</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4Z0"/>
    <dbReference type="FunCoup" id="A0A1Y2B4Z0">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4Z0"/>
    <dbReference type="InParanoid" id="A0A1Y2B4Z0"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="179"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY29155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="548" mass="59665" checksum="208F6DF13996E812" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B561</accession>
    <name>A0A1Y2B561_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_467043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B561"/>
    <dbReference type="STRING" id="71784.A0A1Y2B561"/>
    <dbReference type="InParanoid" id="A0A1Y2B561"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="56"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="207"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY29953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="393" mass="42754" checksum="5AA4BC23393DC174" modified="2017-08-30" version="1">MDNITAAKAQLQNGLKSHQSSHEVDTEALKKPNLALWVNKEHQIWQKEEAFPECPPDGCVIHVKATGICGSEIHFWKRGAIGDCCVTHPIILGHESAGQVVQVGENVKNFVVGDRVSIEPGVTCWECEMCLKGRYNLCPKVQFSGTPPSDGTMRRFVSHPARFLHKMPDTMSYAIGALVEPLSVAYNAVTRAAPYLGQPVLIAGAGPIGLAMALCARAAGAHPICITDLEENRLQQAREMGFEMTVKIDLAWDRHQTAKRVRDTMGPGCVPQLAFECTGAGSSINAACYALEDGGTLLQVGCGAPEISIPLMAMGFREVNIITSFRYTQSWPVVIRLTDAGIFGDVTKLITHTFPIEQTVDAFETCADRSKLAIKVQVGGSVPYQRVSQLMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5D0</accession>
    <name>A0A1Y2B5D0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_530591</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the YME2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5D0"/>
    <dbReference type="FunCoup" id="A0A1Y2B5D0">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5D0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5D0"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="271"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="13">
        <location>
            <begin position="457"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY30013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1014" mass="110977" checksum="ED8EF9DA8575EBC7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B676</accession>
    <name>A0A1Y2B676_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_529303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B676"/>
    <dbReference type="STRING" id="71784.A0A1Y2B676"/>
    <dbReference type="InParanoid" id="A0A1Y2B676"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="309" mass="33428" checksum="3B0E91A90C4A5C97" modified="2017-08-30" version="1">MKVLVLGASGFIGYRVAQAFVRAGHIVYGQTRSESTGKTLPAEEIVPVVCDPLVDAGRAIWGPVASQCDVVVDALAASGGSAAALATFNHFLSLVSKRPRAAPKPTYIYTGGLWSLSRGDGGLESWTDERQPRSDYNPTVAWRAEIEDVVLLEDKVNGTVIRPPIIYGYAASYVGVNIFEPAYKALKDGKKTFETTAAEHTRWQTIHTDDLADLYVRVGERGNICKGQTFLAINPASERLTDILDAVVRITGLESYIVKQADPKNAAWVSTLNAKASLGAALVGWQPKRMSLVDGMPIYWPAFVASKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B681</accession>
    <name>A0A1Y2B681_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_598381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2B681">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B681"/>
    <dbReference type="InParanoid" id="A0A1Y2B681"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="4742"/>
            <end position="4888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4087"/>
            <end position="4626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4135"/>
            <end position="4154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4168"/>
            <end position="4185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4209"/>
            <end position="4219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4227"/>
            <end position="4258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4275"/>
            <end position="4298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4319"/>
            <end position="4341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4392"/>
            <end position="4413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4421"/>
            <end position="4431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4432"/>
            <end position="4442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="4444"/>
            <end position="4458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4494"/>
            <end position="4514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY30348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="4971" mass="548191" checksum="97DBC6FB516BA9EB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7W2</accession>
    <name>A0A1Y2B7W2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_153321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7W2"/>
    <dbReference type="InParanoid" id="A0A1Y2B7W2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="506" mass="56354" checksum="A5D990669AD474E6" modified="2017-08-30" version="1">MSDLEITTKYAPPGEEVKEVEVGDSSYQEFLILSQEFQGKRLDKLTRKIDWHVLPQLIFIYLLSYVDRTNVGNAKLFGAQVDMKMTAQDWNTGLTVFFVTYAIGGPPSNMALKRIGPKKVLPFILACVSLILIGSGCASNRAQWFALRLLLGLFEAGMFPGCCYTLTTWYTPEQIHGRTTIYYCGASLAGAFSGLLAYAIGQADGIWGYRGWRWVYVLEGIFSFIVAMLAFFFLQETPEKQGKWLKEDERRFLVLRNKFMYGGEKGASDDTFRMKDFVTSLKSWHNYVLGFAFFSTSVAAYGLSFTLPTIVKNMGFSAARAQGLSAPPYVFACFCVLLSGWFSDRYRMRMWSTALPSAVAFIGLLIAVLTVTHKNLVPLSYIGVCLAAGGVYCLSPSIAVWIGLNQAGQTKRAASIGLTIFIAQLGGIVGSNIYLTKEAPSYHTGFGCSLAFLGAGCIVVPMIYWYILGRINAKREAMSEEEIYARYSPEELQEMGDLSPLYRYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8E2</accession>
    <name>A0A1Y2B8E2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="3">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIF6</name>
        <name evidence="4" type="ORF">BCR39DRAFT_527828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <text evidence="3">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8E2"/>
    <dbReference type="FunCoup" id="A0A1Y2B8E2">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8E2"/>
    <dbReference type="InParanoid" id="A0A1Y2B8E2"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="220" mass="23818" checksum="3154DC80980881A9" modified="2017-08-30" version="1">MAVRTQFENSADIGVFAKLTNTYCLTALASSSNFYSVFEAELSEVIPVIHTTIAGTRIIGRLCAGNRHGLLVPSTTTDQELQHLRNSLPPQVAIQRVEERLSALGNVIACNDYVALVHPDIDRETEEIIADTLKVEVFRQTIAGNVLVGSYCALTNQGGTINRGSEVIGAGLVVNDWIAFAGLDTTATEVSVVEATFHLQDKTSAAVIREMRDSLIDHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B961</accession>
    <name>A0A1Y2B961_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_526338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B961"/>
    <dbReference type="FunCoup" id="A0A1Y2B961">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B961"/>
    <dbReference type="InParanoid" id="A0A1Y2B961"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="321" mass="36832" checksum="0E36498B48506602" modified="2017-08-30" version="1">MRKFAVQVPEQVSRLLRSSLISTPPTWYQPALANPPPILPARRSRERPPFSWHGEPLTTGDLSRGPTRLSQLKKETQKQRYKPRVIKYEEDKIRTQFFRDYPFEALRATSLVEMRSIESEHAVKGSEWISLEQRGAYPTVEDLVEFVLNLRQMQGLSLSRAYKQATEEFVKLRARHEMATMAAEIEARHWGAEFPTEPFERFHNKLTENLDTNAPDLANKGKIRSVVKYKKPNRLFWSAQVPEEALPSDEYHAGKNYVHKWRLPAPPVMDTSSDSLLAAIDAKVGSPGLDGGKEKEKVEKEKLHEMDDTSFLHTILGGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAG1</accession>
    <name>A0A1Y2BAG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase lambda</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_465497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAG1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAG1"/>
    <dbReference type="InParanoid" id="A0A1Y2BAG1"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="9">
        <location>
            <begin position="229"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="838" mass="93576" checksum="CE0136F07FE78907" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBN7</accession>
    <name>A0A1Y2BBN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_523542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBN7"/>
    <dbReference type="InParanoid" id="A0A1Y2BBN7"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="93"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="302" mass="33490" checksum="3B7D76350DEF6743" modified="2017-08-30" version="1">MMSTPPPLLPSHSTDRTNGTASPPRSAQHYSPNLTQGTPRRSMALSQPEKDHAPNGLAYDKEKGDMSFHSARKSIEISPNLPDDSKQSRKMSAAMIIPIWIALSSAVILYNKYLYSTLHFPYPVFITSYHLGCAAIGTRILRATTNLMDGLDTIHMTREIYLKSILPIGVLFSGSLILSNTAYLSLSVSFIQMLKAFTPVAILLISAIFKIQQLNQKLILIVILISTGCALAAYGELHFQMFGFLCQTAAVMFESSRLVMIQILLQGFKMDPLCSLHYYAPVIIPIHLNSFDHADRLGLLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBR7</accession>
    <name>A0A1Y2BBR7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative mitochondrial inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_523733</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBR7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBR7"/>
    <dbReference type="InParanoid" id="A0A1Y2BBR7"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000147">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial aspartate/glutamate transporter), member 12/13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="343"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="443"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="543"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="695" mass="76843" checksum="2D0B8C41E83AB97D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC43</accession>
    <name>A0A1Y2BC43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_524154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1667110at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="756"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1066"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1337"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1369"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
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            <begin position="222"/>
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        </location>
    </feature>
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        <location>
            <begin position="1021"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1340"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY32100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1398" mass="153676" checksum="18E8C4153E8A4E32" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDB3</accession>
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        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="15" type="ORF">BCR39DRAFT_557385</name>
    </gene>
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        <name type="scientific">Naematelia encephala</name>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
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        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase-assoc_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="646"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="920"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY32822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1459" mass="161854" checksum="EEAC1EFD2AD22156" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDE1</accession>
    <name>A0A1Y2BDE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_504245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDE1"/>
    <dbReference type="FunCoup" id="A0A1Y2BDE1">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDE1"/>
    <dbReference type="InParanoid" id="A0A1Y2BDE1"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42975" checksum="13AD975D3951FCB3" modified="2017-08-30" version="1">MTTTTTSLTTYLTRLRRQHHSLYPPYLLSLPRNITAGDFASASSQRYLLDQILYDPITRSYEPELGYSRRFWRWIVGRLEQGVEEINLMDPGRDEEVDEKFYEALTRFMVDDKPSEDFLPKESYRTFIYNLSSWQIQSAQGGVVDQERYITLLEEQVAVQAGTTGLRTWTAALHLAHHILDDRNILQPDSDGTGNGSFPTIIELGAGTGFLSILLAQLGARVIATDLGDTEDFDHGIKRTPLARLRSNVELNQLQRPPHVIPLDWMDASKPPETWQELIQETPKTIVAADVIYDPDLIPALVTAVRVLLGSDRRNMAVFAATVRNPATLDLFCETCIERQLSVTPLNLAPMDDDDPTFWDSALDRGCLVRLFRLQLADHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDM7</accession>
    <name>A0A1Y2BDM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_522426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDM7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDM7"/>
    <dbReference type="InParanoid" id="A0A1Y2BDM7"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF13">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="7">
        <location>
            <begin position="586"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="8">
        <location>
            <begin position="820"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121918" checksum="FD0C81EF9FBD9CE1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEC7</accession>
    <name>A0A1Y2BEC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEC7"/>
    <dbReference type="InParanoid" id="A0A1Y2BEC7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="204" mass="20922" checksum="8F0C300BAA9DD155" modified="2017-08-30" version="1">MSRPRQAEGPTSPSSTSPTTSTMSSPASPSTTSSPSGQSPNLPTQPGGEASSAASTPSLQSYDSCESGTSPAAPSILSSVGLGLPPTFPPGGSVDSLSPPNDVDSYSSAGDPNPVPPDDGRIARIYGWGRPVTLGSIPDFSRTETTNRSVQRQRASSSARGPDNDVFNTGLGELDEYDNQRRARARAAQSGAVTPTPSQRTEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEX4</accession>
    <name>A0A1Y2BEX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_519723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEX4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BEX4"/>
    <dbReference type="InParanoid" id="A0A1Y2BEX4"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="201"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="552" mass="61770" checksum="EF37C65C9C878CA3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF76</accession>
    <name>A0A1Y2BF76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_520328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF76"/>
    <dbReference type="FunCoup" id="A0A1Y2BF76">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF76"/>
    <dbReference type="InParanoid" id="A0A1Y2BF76"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY33472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="292" mass="32278" checksum="A9F83540AE1A3AD4" modified="2017-08-30" version="1">MQRIRPLYRSIHTSARAQAAPAPARAPYVRRTAVPVSAASRSVSASRPAVSTPTPVFDFPDVDDIPSPVSEIEDYANLAPSRSPNSSVEPSPPLAAFPNDSYKSLPTAPTTIAGEVYTDWTTSFSGLSQTPFSKEAAAELMKPLDPEDIEIKPDGLLYLPEIKYRRTLNLAFGPGGWGLAPRGETNVSEKIVSREWGLVCLGRLVSVARGEQEYFGPHGIPTATEAVKSNALMRCCKDLGIASELWDPKFIREYKEKHCVEVFAEHQMTKKKKKMWRKKNGPKLEYPYKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFL5</accession>
    <name>A0A1Y2BFL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_357769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFL5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFL5"/>
    <dbReference type="InParanoid" id="A0A1Y2BFL5"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="260"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY32875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="357" mass="39116" checksum="62E56DD7B061258C" modified="2017-08-30" version="1">MNNGIPPVLQATSGALGSAVGNALVFPLDLATTHLQLRRSSSEKLTFIQTLHRLLIRRTPRQLYSGLKADTISTLLSSFIYFFVYSSLHKFALRQRRQEANRHLESGLITSPAGIGGMTTKASEMPTTTTKIGSLGIVDELVIGLVAGIVSKGLTLPISAITIRQQLGTDHDDDDEERGDIKSRHNKEHEREKTDRETDKKNKSMTILQAIQAMYQEDGLSGMFAALPPSIPLALLPSLTLYIHTLLLRLVVPARHRAHPKGITTFLLGAASNVLATIPLYPLVLLKVISQSGRDKGKESQGGMLGALNRIMYREGVLGLYKGIEGQLVKGIVQQGVMMLLKQRIEESVVMAYRTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFZ2</accession>
    <name>A0A1Y2BFZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_518918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFZ2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFZ2"/>
    <dbReference type="InParanoid" id="A0A1Y2BFZ2"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="517" mass="57301" checksum="D04CFDDC2D5604D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG30</accession>
    <name>A0A1Y2BG30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_520846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG30"/>
    <dbReference type="FunCoup" id="A0A1Y2BG30">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BG30"/>
    <dbReference type="InParanoid" id="A0A1Y2BG30"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="26"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY33035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="365" mass="39213" checksum="1D051DF79924DBD6" modified="2017-08-30" version="1">MAPIPNGVTVSEPKTHGEKSNKMHSQVVIIGSGPAGHTAAIYLARANLEPVLYEGMLANGFAPGGQLTTTTEVENFPGFPEGVTGTEMMDKFRAQSERFGTKIITETIARVDLSQRPFKYWTEGEEEEADFMTADTIILATGASAKRLFLPGEETYWQSGISACAVCDGAVPIFRNKPLAVIGGGDSAAEEATYLTKYGSHVYVLVRRSELRASKIMAKRLVAHPKVTVLWNTVATECKGDGDLLQSLTIKDTQTGEERDLAVNGLFYAIGHEPATQLIKSQLQLDADGYIQTVPGTAQTSVKGVFAAGDVQDKKYRQAITSAGSGCMAALEAERLISEEEADDEEIAAKDVHVPANGYMGTDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGE3</accession>
    <name>A0A1Y2BGE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_586703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGE3"/>
    <dbReference type="InParanoid" id="A0A1Y2BGE3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="157" mass="16379" checksum="CD08ED7B94B8ABD0" modified="2017-08-30" version="1">MASTNPDNDHHSRSSTHQFWCDLGALVDSICSSGHDDSMHSADGIGETARTANLEAEGNGDNDGYATDADERPEDDDDGYYAAKALHSMDTATHNSADGVTDMANGDAGMETAAVDGADNDASVQTVTETWDTGPMETTTVTMVSGVPLNFCVTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGS9</accession>
    <name>A0A1Y2BGS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stretch-activated Ca2+-permeable channel component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_519259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGS9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGS9"/>
    <dbReference type="InParanoid" id="A0A1Y2BGS9"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="651" mass="68359" checksum="06481F2B48DB5958" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGU6</accession>
    <name>A0A1Y2BGU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZPR1 zinc-finger domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_563762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGU6"/>
    <dbReference type="FunCoup" id="A0A1Y2BGU6">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGU6"/>
    <dbReference type="InParanoid" id="A0A1Y2BGU6"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="54"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="325"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="538" mass="58970" checksum="430ACF46EE16A035" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGV5</accession>
    <name>A0A1Y2BGV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_518798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGV5"/>
    <dbReference type="FunCoup" id="A0A1Y2BGV5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGV5"/>
    <dbReference type="InParanoid" id="A0A1Y2BGV5"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="590"/>
            <end position="609"/>
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        <location>
            <begin position="621"/>
            <end position="645"/>
        </location>
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            <begin position="534"/>
            <end position="569"/>
        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="1"/>
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            <end position="106"/>
        </location>
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            <begin position="141"/>
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            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="921" mass="101093" checksum="4248A751E61F945D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH53</accession>
    <name>A0A1Y2BH53_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_235341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORY34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="107"/>
            <end position="118"/>
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            <begin position="119"/>
            <end position="130"/>
        </location>
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        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="287" mass="30464" checksum="F0EFBD1C789E55C3" modified="2017-08-30" version="1">MYQMGYAHTATMSPIGGSILLSRSHSTLTLSSSDSSGQDGYQPSPQYPALATPNRMGFVQSTPDLTAMEMTPNSRQRSQSSPQVAVDAGAQSPSSGKAQRFGRPSPLNLQRQNSYHGTSPSPRRPVSLSRTNSTQSGLRRSRPGSLAASAFGITPIVGEDQVSPLNSPLTSASSSVGTHSRQRSDVSLAPFMTSMSGMTISPDMSDSGEPGSVLPMQMTVPPLTPITPGQGVANGVFKTTDYGDMATEVPRYATMPNKHYETTHYGHQIYPSSDFGPAYAPQNSAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHD8</accession>
    <name>A0A1Y2BHD8_9TREE</name>
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            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">BCR39DRAFT_516734</name>
    </gene>
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        <name type="scientific">Naematelia encephala</name>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORY34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BHD8"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF22">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="374"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="718"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="655"/>
            <end position="717"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
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            <end position="31"/>
        </location>
    </feature>
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            <end position="70"/>
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        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
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            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="744" mass="82575" checksum="B0D4F472D7AFB070" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIH7</accession>
    <name>A0A1Y2BIH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_462650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIH7"/>
    <dbReference type="InParanoid" id="A0A1Y2BIH7"/>
    <dbReference type="OrthoDB" id="2594165at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29738" checksum="993A5C16CEE86D8B" modified="2017-08-30" version="1">MADETKKEKQPWLGKHTFPLIWIWICVFFNVFGILSHIMLIIAEFVVLASDFSNYVKQFGHNYASRQYQLNAGCGFVPYTNAPTHLGSAIWTLFYQLSVIILSLLTVASDLAWRTAQSEWGGRYVSAFFAVGIMSGEHNKGLFYYVVANGFLKLFIVVMYMSQSFYGLGGGSHSFPSSSSISGSSSISGSSSISGSSSVSGSSSSSSAWRRGGWEIPSSSGHDPNSSWGTELWAFWAGWTVLGSIIPSIIAFMVSTIYSIYLLHLVPNVEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIR2</accession>
    <name>A0A1Y2BIR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_513956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIR2"/>
    <dbReference type="InParanoid" id="A0A1Y2BIR2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="170" mass="18447" checksum="7C2C11E584ABD816" modified="2017-08-30" version="1">MSQGIENPFVPPVPPLPSLYTPSGQVNSIPRQPPSVPRRVPSVPRVPTSYSFDDIYGGYSAPSRPGTTHTTHRRASEIMTPSTSSLLPWRSNDTPAPPVPPINHHAFTTNGYQGTSQHRQPRIPTPKAGGKRRSPPAPQEEIRGPIVPMAQTPGMGLSEHGWTGVIPNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIV4</accession>
    <name>A0A1Y2BIV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_556220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIV4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIV4"/>
    <dbReference type="InParanoid" id="A0A1Y2BIV4"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="112"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="253" mass="28823" checksum="3164B3F471E88778" modified="2017-08-30" version="1">MQLFALRLPVSLPPDVYDRLSQLLSEDARARLARFRLIEDAHRSLVGRLALRWYLLRQGLIAPDKEPVFGRTGRGKPTVVWPDLDPKLAFNNSHEGKYVLLGISRGSTPETGVDVMELPSNPEDVEEGISLQLSFSERASLAIALTTNQRARRITTLWTLKEGYTKAIGQGILFGMERICVDLDDITGEPKRVKVDGKDVEEDGWSWKVGKLGVQDEEQYGWAVYWRPEDHNQDFSVEEIDWHDFVKVFDDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIY5</accession>
    <name>A0A1Y2BIY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 8-amino-7-oxononanoatesynthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_518287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIY5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIY5"/>
    <dbReference type="InParanoid" id="A0A1Y2BIY5"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="35"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="445" mass="48827" checksum="17A25D0E63ED6177" modified="2017-08-30" version="1">MTDLDERLSRFIDERKSKGRFRKLREYDTSANSSLIDFSSNDYLSLTSSPALRQAYLARLAESPQVLGSTGSRLLSGGTPAHHVLEDRFASFFNSPSALLFNSGWDANVSFFSTAPQHDDWVVYDELVHASVHSGLRSSRVKQERRLAFKHNDPSSLSDVLRAIQYPAGGTVFLALESLYSMDGDFAPLSQLLDVLDSHVPPSKQCVVLDEAHSTGVYGVSGRGIVRALGEEGRVAVRLMTFGKAVGCSGAVLLCSPTIRTFLINFARPLIFSTALPHSTLISLSCAFDLLESAEGERRRLALFTLSRYLDSLLAPLLAETPRSVLSLPPTSPTPFPQSTCPSLPPCPPSPILGLITPTPHALSAYLLERGFIVRPVVPPTVPPGMERVRICLRADMGTEVLDSFVEGIREWVKTSREQSERTVSSNQNTSMIQKRPRIEVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ15</accession>
    <name>A0A1Y2BJ15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_462158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ15"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ15">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BJ15"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="549" mass="58211" checksum="E3A606F954C8BD00" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ52</accession>
    <name>A0A1Y2BJ52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_556308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ52"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ52"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ52"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="268" mass="27808" checksum="F79722801D0A923B" modified="2017-08-30" version="1">MPKRSAASGLFADIKNDMVAMAGEFVGTVLFLMFALGAVQLTAAAQPAAGAGTQAAGDASGKIIAAFYVSAAFGISLFAFASVFFRATGSIFNPSVSLALVLTGVIKPLRFVLVSLAQMVGGIVAAAIVDGLTPGKLQAGVALSNGTSRTQGVFIEMFTTAGLVIAVLMLAAEKSNMTPLAPISLGFTLFAVMMFSVQFTGGAVNTARAFGPACIAGFDDYHWIYWVGPTLGALLATAFYVFLKYVHYWRVNPGADSTEEEGSPMQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ80</accession>
    <name>A0A1Y2BJ80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ80"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ80"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="425" mass="47156" checksum="504AC6D17222CD4A" modified="2017-08-30" version="1">MYNRPSVGRSDLGGYNGSNYDPTFHRNRQNLPQPPQNNGYARESPRQETKRVGGKYIQPVDRVPQNSAPLPVPPLRESYRQPSPPRQPPPKGPPTTSPPPVSLISSPVSAVQVHPSRLAQIPAANIARPPPPPLRYSSSTENERNGEYRAYTPTVRSQPPVLLQTISSDTTPSPITPGAPTLNSLESIRQFRAQVQASRAIREAPGVDHSRLETLAESFLNSQHPAPLPQDTKEEEKEPGEISEPSSATTMPDERKSREILLKEKLLAARNQLQASKRDREDPRFGEQGGIKRPRAEDGVEPPVSAKSNGPPTGPRNPDVPLRSTASLPTLEKGRDISLGNREIRQADRQADPLREERAKQWNKSSLPPRPQTLPDDRGYLQPSEKNFVTQRYRNSQQRQSRSPVKRDDTSSKGRDSGGNRSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJE5</accession>
    <name>A0A1Y2BJE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_136388</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJE5"/>
    <dbReference type="FunCoup" id="A0A1Y2BJE5">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJE5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJE5"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="47"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="139" mass="15609" checksum="BC13F95E4C455494" modified="2017-08-30" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSSATTGATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDMALARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJN3</accession>
    <name>A0A1Y2BJN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJN3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJN3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="220" mass="24671" checksum="CE48748863701956" modified="2017-08-30" version="1">MERGYDNYVYRALAGMAREQSWVRRQYPQLTYRFFVPSSFDPKVQRSPAVTSNSSQLQSQWRQPPPGWWARASADEGNTLGSTARRTEGLLPKANRSTIPFSTVTSPHYSEHTQSELPSRASTHLETEPGDLNRQADSFSVLLVWGEKIVVNADGALREAETLTICPVEPNPDYPTPVEFYEFWKEVSTPCGPGSSLAQATRRWNEAQTSASQSNTGNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJQ9</accession>
    <name>A0A1Y2BJQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_503441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJQ9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJQ9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="404" mass="45797" checksum="032CB709694FB997" modified="2017-08-30" version="1">MTEGGVSVNCVIEGLLLWSVEVGTAFASRALEWEKPRRGQKGWWDKFTFATLPPQLLVMLWSHNAENSWESSLVRVVVLASYVVILFGHLAKDAESRKGIRSLSQTSRYLRETVPLSSLSFETTVPRILTKTGEMYTHFDPLIGNKVTGLTLESGAEVSELRTEQLRSLTLSGSFIGDGMINPYGGCWTYDQRKTVEDFLERCPELVQLTLRPSVLASRADLAAIIRMTSKTKCRRLSFPLHDADKTRTNITTLSIPAVITDIDFKDGNELCSFVQKIQFSYEELIKYALLPCSMESLEGVENYWGLDPLFFEYPNRAPRGFVELNDSTDTIKQHKKEGKYLMRICEGSMPWGTEGSRKKLIKLDPDMNDEERFRITSELAGLWRYSYSVDAVPREANSILFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJW1</accession>
    <name>A0A1Y2BJW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_516325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJW1"/>
    <dbReference type="FunCoup" id="A0A1Y2BJW1">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BJW1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="73"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="57587" checksum="4576B8B7D7E2523D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJX9</accession>
    <name>A0A1Y2BJX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_503518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJX9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJX9"/>
    <dbReference type="OrthoDB" id="10673371at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="646" mass="71549" checksum="0D08DB6BE7449207" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJY8</accession>
    <name>A0A1Y2BJY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_556424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJY8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJY8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="222" mass="24544" checksum="18FD0486090541E3" modified="2017-08-30" version="1">MASRRLSPSESRSRSPIFNNHSPFSTCTSLSTPLQPHTPTNMVSPLVAPRISELRNSISETTDLIVSATIEAPPPRRRSDGDVWLELLRSSSTTTITTTSSSTSPKTGSSPKVKVSRRASEPFESFSSASRTTSMGLGLILSTTEEEDEDIDGVDEARLFGDRVPDWSDFKEHCFDQLPPPVQTRTQLRRHLADPLVRKLLVTVFVVSTVFGLSYFTFRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKM4</accession>
    <name>A0A1Y2BKM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_513812</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKM4"/>
    <dbReference type="FunCoup" id="A0A1Y2BKM4">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKM4"/>
    <dbReference type="InParanoid" id="A0A1Y2BKM4"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="36"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY34645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="368" mass="39605" checksum="ADAA1A9D80FE8D57" modified="2017-08-30" version="1">MRAASSLLRTALRPVSRGYATSTLGFGREVEGFVGAVGNTPLIRLNKLSEETGCNILAKAEFMSPGGSIKDRAALYLVKDAEEKGQIRPGGTVVEGTAGNTGIGLAHVCRSKGYKCVIYMPDTQSQEKIDLLRMLGADVRPVPAVAFDNPQNYNHQAARYAASLENAVWTNQFDNQANRNAHILTTGPEIWEQTDGGKLDAFICATGTGGTLAGVTRYLTEKSDGRVQGWLADPPGSVLFNLVETGKAAREGNGSITEGIGQGRVTNNLAPDLSLLTGALHVPDSKSIEMVYRLLDEEGLYVGASSALNVWAAAELGRKLGKGKTIVTILCDGAYRYQARLFSRVWLESKGLVQYIPERLQKQYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKN5</accession>
    <name>A0A1Y2BKN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7727 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_585621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKN5"/>
    <dbReference type="InParanoid" id="A0A1Y2BKN5"/>
    <dbReference type="OrthoDB" id="2110422at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="148" mass="16163" checksum="D8E527FB8FDA220F" modified="2017-08-30" version="1">MGKFIWSDWGRLLALSAAGSSIWAFIFRKFFWDMIGGTLGTEGIIPGNNTKALVLITVKVPLLQIFTLLLGLLAATLDAPLPWLYGTAIHRSMMLRVILYFLTGFVGIMVYQTVECAVYFVIVSAVYLKAMLAGETIAGKTAVHSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKN8</accession>
    <name>A0A1Y2BKN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_508876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKN8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKN8"/>
    <dbReference type="InParanoid" id="A0A1Y2BKN8"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="897"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1174" mass="125972" checksum="F269D8C7EB816E38" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKR1</accession>
    <name>A0A1Y2BKR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_509101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKR1"/>
    <dbReference type="InParanoid" id="A0A1Y2BKR1"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="434"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="968" mass="105272" checksum="FEA0A0C139102454" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLD8</accession>
    <name>A0A1Y2BLD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_510904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLD8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLD8"/>
    <dbReference type="InParanoid" id="A0A1Y2BLD8"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="302" mass="34241" checksum="0BC909F32DA0272E" modified="2017-08-30" version="1">MSRSPEASASPLDDGRYRRMSVDSGHDRPEADEAPAKRMRTDAKVEDKARSKRLFGNLLGTLQKFKKEDNKARSSDSAKRREQVSERIASKIRSETNLHHEILEVEKELKTLRIGTDSAETVLKHKEAAMIARHTTLRPVSKFLHTSASTQPLIFETTLLAPSPIPLNRGPSRIPPPLEQAKPLYFLPKILLSHQDELLNRQISDIDQLIADESSALEKEKVDTAETVKRNRARIEELVAKLSELKKQVKPDSDIRPQAPTRDSFGRNARRDRQDEEQKGMDVDREAAVEIRGEDGDIEVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLM1</accession>
    <name>A0A1Y2BLM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_26391</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="196131at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DEADc_DDX3_DDX4"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="213"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="415"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="583"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
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        </source>
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            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="658" mass="69454" checksum="35B0C23F53C90A68" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM49</accession>
    <name>A0A1Y2BM49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcipressin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_585439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORY35844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Calcipressin"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN SARAH"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="303" mass="33322" checksum="FF85303A18841085" modified="2017-08-30" version="1">MTATPPRSISIPSPPSLIDTKPESEPEPTNSYALLLPHPALFSPPILTLLRDYYEQYGKIAHWAPVRGFGRAIIVWEQVEGARRAKQGGDWLKLDVDVSVPVSKNQESIQREDRNYFSPVRKRRKSDHSNGITLRLFALPYTPLNQDPSTTHLAPPHPEKNFLISPPGSPPEGWEPIIEEAPNASTLANDLQRALEALQLNGSRRGRSAKEVILDEGGMRVEVEDTSQLERTSQQGEEQEEEGAGGGGGEGEEHIQQEWHGVEEIIQRGHGAWTSPSQERGIGSALGTPSGKIKIIPTAMPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BME1</accession>
    <name>A0A1Y2BME1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramic acid-6-phosphate etherase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_513119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BME1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BME1"/>
    <dbReference type="InParanoid" id="A0A1Y2BME1"/>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016803">
        <property type="term" value="F:ether hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000014">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00274">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003915">
        <property type="entry name" value="PRK05441.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009222">
        <property type="entry name" value="PRK12570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF4">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22645">
        <property type="entry name" value="GKRP_SIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="56"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="311" mass="33072" checksum="429D42239887ADAF" modified="2017-08-30" version="1">MENFTGLQTEQRNPRTKDIDVVSTLDMCRMINQEDATVHSAVAECLPVIANIIDEIAPRVARGGRVIYVGAGTSGRLGILDASEIPPTFSAPYGQFVGMMAGGDYAIRNAAEGAEDSITLPVSDLDALQPPIEPEVDSLIGLAASGRTPYVLSAMRSARERGCFTAGICCVSPSAMRETQTVVVECPVGPEVVTGSTRMKSGTAQKMILNMISTGIQIRVGKTYGNLMVDVKCSNEKLVDRARRIFRTVIESLGPDVQCDTPNSDNGIDSLIQECGGSVKTAVVAARWSTSPGEAETRLKEAGGKLKFALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADC5</accession>
    <name>A0A1Y2ADC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_83783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000133">
        <property type="protein sequence ID" value="ORY20512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADC5"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADC5"/>
    <dbReference type="InParanoid" id="A0A1Y2ADC5"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16417" checksum="1BF171A59F7B7A8A" modified="2017-08-30" version="1">MVFDKFRTKIHSHFSSSPIATQRDEFLAVNSTTPLERKAHFTPEIVGGAAAYEAMKAFEHHEVHKGSKPTHARAKEIIAGIATGYAVKLIEEKNLPFSSEVSKKKFKAEAQLYAARDSKRALRESSFYGGSELDPIDNDEKYGNKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADE1</accession>
    <name>A0A1Y2ADE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_474975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000131">
        <property type="protein sequence ID" value="ORY20579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADE1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADE1"/>
    <dbReference type="InParanoid" id="A0A1Y2ADE1"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY20579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="248" mass="27461" checksum="A7D0A575ED2EA8B5" modified="2017-08-30" version="1">METYTLSAFPSTYSTIHIALFRNVTNAPEIRKRLIRASTLEGDLGDRARAEVDFGFIEASLVAPSSSTSTSTSYPSSPSTPTTSSSNTQNPSNSPLTPTPTPPTIPTPTVQPQTRSHNLHSEVLLSLSPNNNITDSIRRHGISDSTSFLAVIRFGPRTTPPEEVYQAMKVVVDGQLVSLDELGQGDNLDRIKVDKVCFCLVLSSILFNFAHSVLFVHFFLFVHSCSFLFYLFYLFCLFICYHQQIGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADS0</accession>
    <name>A0A1Y2ADS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II elongation factor ELL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_554905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000127">
        <property type="protein sequence ID" value="ORY20709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADS0"/>
    <dbReference type="InParanoid" id="A0A1Y2ADS0"/>
    <dbReference type="OrthoDB" id="2587563at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="69254" checksum="21710A6E8B56EE42" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE10</accession>
    <name>A0A1Y2AE10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_555281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000133">
        <property type="protein sequence ID" value="ORY20507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE10"/>
    <dbReference type="STRING" id="71784.A0A1Y2AE10"/>
    <dbReference type="InParanoid" id="A0A1Y2AE10"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY20507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="426" mass="45308" checksum="6E9961D45416EF0C" modified="2017-08-30" version="1">MSLPAYQPSSSPSTNGPPVSTNSGINDETSYSYSNEFMSSSVYSDGAGAGVQSESGTWTTNVYLTTNTLGNPILTTSTSNTNTNNSNNNSVPEKGGVRLSIVQIVVIAVSVGLFVVLFTIGAICCRRRRRLRRKLDKETFINETKMYGGGDSGGAGAGAGGGIDNNNGSGGGGRGRGRNGGMGMGLTTGEVLEVVPLPAPGPRPRRGLSASSSRSSGGVGGSIQRDSIWTDDSEFDAFAVDGSTATRTLSTANSIREFDQDEDDPFNHPAYTYQPHSSSSLAYPPRAGTSTSSIPPPPAPPPPSSSSISTSKESTQRYNYDYNHTYASSSGDNSSSHQSPTSYTIQTPRETASYNPSLVSDYSHTQWTPDDRYSLPSTTWQLRRGQSVIRHSDAGRFEEADEEDEPLHLPPSYGDIFPTRATTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEH8</accession>
    <name>A0A1Y2AEH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_554504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000122">
        <property type="protein sequence ID" value="ORY20912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEH8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEH8"/>
    <dbReference type="InParanoid" id="A0A1Y2AEH8"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="120"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="251"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY20912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="346" mass="37562" checksum="E3AC1C0C4E5143BF" modified="2017-08-30" version="1">MSAPDEPSGGSALKEVVFGSIAGMTAKVFEHPFDLVKVRLQSQSTDSPLRFTGPLDCFRQTYIKEGWKGLYRGISAPIVGAACENASLFLVYNRLQNLILYLRPENDQSAIIGGTSRRELSTPELALAAAGAGSAASFVMTPIELIKCRMQVQMLAREGAFSHLAPSTLSTQPSITLHTLPPLQGPLSLIASTVRTHGLRGLWLGQMGTLFRETGGSSAWFTSYEVSSKFFLRRLQLSKPDPDQTLTKSDLPAWQLMASGAVAGMSYNIVLFPADSVKSAMQTWAELHPDKPRLGFWAMASRIWKGRGLRGLYAGCGLTVARAAPSSAMIFGIYETLVGRFGYLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AET6</accession>
    <name>A0A1Y2AET6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_474669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AET6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AET6"/>
    <dbReference type="InParanoid" id="A0A1Y2AET6"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09880">
        <property type="entry name" value="PIN_Smg5-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="695"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="859" mass="95154" checksum="6D710CBED95E5FAB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEU7</accession>
    <name>A0A1Y2AEU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_554232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEU7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEU7"/>
    <dbReference type="InParanoid" id="A0A1Y2AEU7"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="493" mass="54635" checksum="AB9B27906848B2BF" modified="2017-08-30" version="1">MSNPSQSILIIGAGVFGLSTAIHLAKRGYKDVTVIDRQPFDKNFYHPDDGCDGASADINKVFRTTYGDRKMYQDLALAALPIWRVWTAEVQASSPSDLPDGLDPSDELLSESGFMRTGSGAQLSDFHKACLAGIEADNRRERVFVLKNQDDFKRAKEADELQPGYHWADKLNRYNGLLRGDIHGLLDRDAGFTKADKACVWALHLAKKAGVNFILDSKAGAFSSFITTGTEGDRRVLGVQTQDGKEHRADKVIVACGGWTASVVPEVSSLLETTGGSLAFIDIPRDRPDLLQRFGPKEFCTWSFESAEGTGMGGFPATEDGRLKFGYREVKYTNFVTHPVTGTRLSVPRTKYSPDPIHNIPLHALENIKRIIRSIYPELAAIGITETRICWYTDSIDNHFVGDYVPGYGETLFVASGGSGHGFKFLPVFGENFVNQLEHKQDEFTQYWKWRKPVPGQRANGLEQGEDGPRVLDKVKLATKDDWKFGDESLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFE1</accession>
    <name>A0A1Y2AFE1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_508444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000116">
        <property type="protein sequence ID" value="ORY21216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFE1"/>
    <dbReference type="InParanoid" id="A0A1Y2AFE1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="183" mass="20980" checksum="C373777DD193A1DA" modified="2017-08-30" version="1">MAETRQRLVMVAYRHPSYPKVTKSCFGPFRADRQRHRDRHLPEKLGFMKWLNGSRAISDNSPVNQAGNISQEEVVQMDVMEGDDELPVFYHRKLLADQNARIILVNSSEMDQFIGFLTTPGVRNRSSVPPNLRHYVDVIHSASSISQSIHTPHSGRHHLQSPRDCCFSVTQHISEVWHSNRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH94</accession>
    <name>A0A1Y2AH94_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_552749</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000103">
        <property type="protein sequence ID" value="ORY21852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH94"/>
    <dbReference type="STRING" id="71784.A0A1Y2AH94"/>
    <dbReference type="InParanoid" id="A0A1Y2AH94"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY21852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="578" mass="65006" checksum="3D0E2F3FA85B36A5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHQ8</accession>
    <name>A0A1Y2AHQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_552424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000099">
        <property type="protein sequence ID" value="ORY22036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHQ8"/>
    <dbReference type="InParanoid" id="A0A1Y2AHQ8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="132" mass="14416" checksum="4CDDBA19D208B6CC" modified="2017-08-30" version="1">MQPDAKPTMSDKLTGKFKVLVGKTTHDPNRIIEGTAKETGQAQAINIPIREISNSNSHQNTNGQDSEEEDEGNYKDGEGDGEENKLETQISPPAGMAGSYEREKSLKKEQSKLDGDAFECANGLKKDGKYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI03</accession>
    <name>A0A1Y2AI03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_552707</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000102">
        <property type="protein sequence ID" value="ORY21910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI03"/>
    <dbReference type="FunCoup" id="A0A1Y2AI03">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AI03"/>
    <dbReference type="InParanoid" id="A0A1Y2AI03"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="457"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="699"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1005"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1021"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY21910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1100" mass="118668" checksum="3869C9413E7F5759" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJL2</accession>
    <name>A0A1Y2AJL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_550851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJL2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJL2"/>
    <dbReference type="InParanoid" id="A0A1Y2AJL2"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY22758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="464" mass="49934" checksum="5431C94C730153AA" modified="2017-08-30" version="1">MRITRFAELRHRRLTLLGRALALVSAELLANAIVWTIAGIFLSQADGLMGLALLAWTIGLRHGLDADHISAIDNATRQLVSLGQLPITCGLFFSLGHSTIVIVVNIALAISINIYDKLDRVGSVGGIVGTSISSTFLFLIAVINTYFLISTIRERRRTDRLRARGLPIDEAEQVGKIHGGGCLVRIIAPVLRAVNKPWKMYPVGVLFGFGFDTASSIALLGISAVATRGPDGETINHGKIVILPFLFTAGMTLVDSLDSVLMLYAYAAPALGTQQRRLAVFEDRKTPLPVTLPDLETPPVTVELLNSNPPTAEIEEDDVVKPTDDATKPTGLDQEQEPGQHLPEDTSTSNRQRVLNGKANTMSTLSIILTLLSILVALSISLIQIMGLIGDNCSSCTKAAQDPNGGGLAGSWWRAWGRANDQSGYIGAAIVGAFLGIVVGYYGGRWCWGKWRHRKGPSGMLHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALI9</accession>
    <name>A0A1Y2ALI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_549379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALI9"/>
    <dbReference type="InParanoid" id="A0A1Y2ALI9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012192265" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6980" checksum="2C57A1901B13FB95" modified="2017-08-30" version="1">MRSLSFSLFPEILLLLLFSCAVKYCFTTPKCKCSRMIISKDGAHSFHHVTLHQQACYKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALV0</accession>
    <name>A0A1Y2ALV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_549636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALV0"/>
    <dbReference type="FunCoup" id="A0A1Y2ALV0">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALV0"/>
    <dbReference type="InParanoid" id="A0A1Y2ALV0"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="123" mass="13737" checksum="BC0758BC366BAD39" modified="2017-08-30" version="1">MSTQPLLQRTAQKRIALPIRVEPKVFFANERTFLSWLHFSVVLGGLAVGLLNFGDKVGKISAAMYTIIAVGVMLYALTVYHRRARSIRLRTGAPYDDRLGPTVLCIMLLSAIVINFILKAVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMU9</accession>
    <name>A0A1Y2AMU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_549124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMU9"/>
    <dbReference type="InParanoid" id="A0A1Y2AMU9"/>
    <dbReference type="OrthoDB" id="2565062at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="342" mass="37291" checksum="41E10876AB56626C" modified="2017-08-30" version="1">MGYTIILQWTLPPSPTRQLNLSEIISTRILTHYSLSSPTRSTVQFRTYRTSSLELTTIMYSPPLPAVRDLVIQGVRDDTAYLFLEARHTSTASQENGQSEKQEDKIKAKTEVIEDDGFEIIDPPPPLSLSSTKTSTAVGGGTPVGDSGDNNASSSKPGVSGPGAKKARYRIMAVRPAVSTVPMLQNLLSPLVLGLTKAARAAATTTGSSLPTPTPIPGTSHLLTSLTYPPLPTPLPTIRLTVHILPTTSSSSPQSIILEGEFVRDTALPHSRHSYQETILRECLEGCIPVGTGEIRWFTWDAKNDKDDENKHDDDEKSWQGIERTRRASYLLAKCLKESSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANH4</accession>
    <name>A0A1Y2ANH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_547721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANH4"/>
    <dbReference type="FunCoup" id="A0A1Y2ANH4">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANH4"/>
    <dbReference type="InParanoid" id="A0A1Y2ANH4"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="360" mass="39583" checksum="98CAB33F45F1D9CE" modified="2017-08-30" version="1">MRITKKQLAGIDQYKYSGVDKSVVSKHILGPFWTWLVTLFPKTLAPNTITFLGLCFVFANVGTLLVYDPTYSGRDLPSWVYFSWSFGLFAYQSMDAIDGKQARRVGMASALGEMFDHGCDAINTSLEVVLCAHALGLNRSWWTVASEAASLCNFYASTWEEYHTGTLYLSAFSGPVEGILMICVIYLITAIHPSGQGFWQQPLTSLIPGSFAAQAAHSIDETFGLKGNKSIEALPVNVAFMMFGALGTVGNIVNSYSNVLIARKKAGKPLLAPLLGYLPFAAHTAILVFWLQAELRGGVSLVHDARLLPFLGYWGMSFSYQVSQLILAHVTKSPFPYWNGMMVYSLFGAVDANAEWLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANX9</accession>
    <name>A0A1Y2ANX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_472551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANX9"/>
    <dbReference type="InParanoid" id="A0A1Y2ANX9"/>
    <dbReference type="OrthoDB" id="10620064at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="137" mass="15544" checksum="26EEF71699F76093" modified="2017-08-30" version="1" fragment="single">EEMKSIPRMFEARFRYEQIKFGTDSSLLTDWVIAPNTPEMMRLLKWPQQEDGHSCGPLSVAAALLLIQNIKPTEESLGIRGNNLSERGSKALRQSAIQLFLTCWGEQKCSNSVWGDPKIQKVIQKYSKDLEILFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APE2</accession>
    <name>A0A1Y2APE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APE2"/>
    <dbReference type="STRING" id="71784.A0A1Y2APE2"/>
    <dbReference type="InParanoid" id="A0A1Y2APE2"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="464" mass="50979" checksum="F80B09F62145A2FC" modified="2017-08-30" version="1">MAIVEEVADDETDVPQGEENPLVAASKVEELAARLTPPNELLPQFLNEAKPEESLQIYRSTSERILETLKANLVSPEFASLPLETQSSIILPVLRLSQPSPYTSPDILTAVSGITSSLPSASDVAVYILSNVLKPLFRPSAHPMLNPSTSRALSRPAGGQQAFSDFSESSTQIFKSPQGWACDHVLAWCCDQLDPGQVERHIGLILPPSLVMMDDWEPPWRGRGITVLSKWVEKIDTVVLKRMGLDKLLLDSLIHTLSLHPNPPLPQALPAALSLIERTMSGQAMADRLAEIMDKAVLQGWMYAPSGNDGRAVLIHIAGMAETLCGVFGIGIARWLKTIIPNLLDPLQYTPTTAVLPHHQANLSALLCTMKTLRGTERIARWRGKILDVLSRLWLNLADRGSLLPESSWHTETEAEEPIKQVRILVVAVIKELADQCPSVKKNEFQTLLDLDKTVFATLIPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ78</accession>
    <name>A0A1Y2AQ78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_546337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ78"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQ78"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ78"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="474" mass="52165" checksum="F294F81F0118322D" modified="2017-08-30" version="1">MSIFSSIKMLKSSTRARWLGDNLINHSKSPKAYPRYFSTVRRSSTSSRAESSKSNSDGGAGNELAKIIRDSIKATGPISVSKYIQFALSHPQYGYYTKGDVFGSRGDFITSPEISQVFGELVAIWFLTRYIAEARGKKCRIVELGPGRGTLMEDMLRTFSSFPDINSSIAAIHLVENSEKMRGLQLAKLGKRCEVAGISLEWSNDIHDVPTDFDGYTFVIAHEFFDAMPINIYRKTQEGWREVKVDLEPSLSMVPSSSTPVLRPSAPSSGLRLSLSREATLTSNALTKTSPRFTSLPDGSQIELSYDSWKIARRIGQLCAVNEEAENRCGGGSALVVDYGGDRAYANSFRAFRNHKLVPIFDLPGSSDLTANVDFAYLKESLIGLDARALGPISQMSFLGSLGLETRTKRLLDAATPERRDDIRKAVDRLINPLGMGTQYQVMAITGAKEGLEVYPFVVGLEGVEQSSERSTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQA8</accession>
    <name>A0A1Y2AQA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_545829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQA8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQA8"/>
    <dbReference type="InParanoid" id="A0A1Y2AQA8"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="158" mass="16710" checksum="F55FE160755B8E6E" modified="2017-08-30" version="1">MSIQFAPQYAKSIKPTGSSLTPTTDTPPVLSKSSMPNVPFPALSASQRSSSPTTATSTGQPLSYSRVIHTPVSPAFPHDGSYFPLAEGVSGNADGHPFRYSAETMLSLWDEEKVKAVPIELFDLADGGAGLVSRVPRKPAGLGEFSEQQKKVCSQGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQH2</accession>
    <name>A0A1Y2AQH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_581463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQH2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQH2"/>
    <dbReference type="InParanoid" id="A0A1Y2AQH2"/>
    <dbReference type="OrthoDB" id="2591431at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF3">
        <property type="entry name" value="CLEAVAGE_POLYADENYLATION SPECIFICITY FACTOR A SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012440658" evidence="3">
        <location>
            <begin position="18"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="561" mass="59036" checksum="53F38E0CBE8E30F5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR86</accession>
    <name>A0A1Y2AR86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_545485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR86"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR86"/>
    <dbReference type="InParanoid" id="A0A1Y2AR86"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000380">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="520" mass="56534" checksum="3A89E1C30E0D7997" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS21</accession>
    <name>A0A1Y2AS21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactosyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_544488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS21"/>
    <dbReference type="STRING" id="71784.A0A1Y2AS21"/>
    <dbReference type="InParanoid" id="A0A1Y2AS21"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="303"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY25363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="115761" checksum="A0147AAB8D9E9B19" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS90</accession>
    <name>A0A1Y2AS90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autophagy protein 16-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_545228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS90"/>
    <dbReference type="STRING" id="71784.A0A1Y2AS90"/>
    <dbReference type="InParanoid" id="A0A1Y2AS90"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="3">
        <location>
            <begin position="34"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="239" mass="27310" checksum="67989E642E2F98D1" modified="2017-08-30" version="1">MSTLITTQGQAGPSNSHPEWQNVIKSRMMAQQAEGEVYREIIDQYRRLAKTARELRIRNRALLRSGAGSSNAPDGQPSPLLAHLDKQLSEHRAEISQLYRTQAAAQNKQLALSDALRDRDDEVRGLREEVRELREARDKALSRERDWEERWRVRGKDMEALNDELLSLNLELTALSQRNSALQGDNAALLQRWLDKMNLTAEEMNDEFEKEAKESKKGKEKELLGTEGEKEDFRDGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASB7</accession>
    <name>A0A1Y2ASB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANTH domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_499170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASB7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASB7"/>
    <dbReference type="InParanoid" id="A0A1Y2ASB7"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000036">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="614"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="697"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="809"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="839"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="880" mass="93642" checksum="4F619E41C443233A" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATC5</accession>
    <name>A0A1Y2ATC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_286180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATC5"/>
    <dbReference type="InParanoid" id="A0A1Y2ATC5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
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        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="324" mass="34836" checksum="E1B1B838C1739F88" modified="2017-08-30" version="1">MSVRKQDEQQYQLPAPRATWSPSDMQPEEMQVTLDRWRSSEFPSPDNLPLQSTPIFPDMLASFGPMYSIAGFTAGGRSGMLGFRPINAQVGPSGQLSEHRAPNGSIGHHGQPPFSNLASTQSYSPGDSDMIFQDAFSAQTSTLDELPIQTYSTAVRMANDHMVGSPSSRESDEFLALLLDNDHTIPSLPNDLDWSSLVNLSTDHAPPLPVPVNDLTLPHPPASLISESASNATPTNDKPVSTSSPTSSPETFMNDTAVTELHITSYNRLPPLVNTLSAHSTPLGHTSKCSRCGTTTSTRFALNSGGKLVCNACRIFTLMHAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATD4</accession>
    <name>A0A1Y2ATD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_589982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATD4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATD4"/>
    <dbReference type="InParanoid" id="A0A1Y2ATD4"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="280" mass="29819" checksum="94B2E7B649AAA3F6" modified="2017-08-30" version="1">MSAVSRTEFPGVALITGAGGTGIGSAVAHAFVREGCRKVILTDVNPTTLESTCTSLKALAEHSGKEEKIAILVVSGDISDSTFVDHLFSRIKEDFGRLDYAVNCAGIIGNNLPSSESAVEDFDRINGVNYKGLWLCSRKELELMKGQEIRERAEYGGVRIQRGSIVNIASQLGIVGRPNAPIYCASKSAVIGLTRCDAIDYSPHLIRVNAVCPGIIDTPMVNNRPTGAPAMDISKSIAIAPMNRVGKPEEVADVCLFLCSEKASFVQGAAWLVDGGYTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATG4</accession>
    <name>A0A1Y2ATG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_544538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATG4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATG4"/>
    <dbReference type="InParanoid" id="A0A1Y2ATG4"/>
    <dbReference type="OrthoDB" id="5319015at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="2">
        <location>
            <begin position="410"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="681" mass="74169" checksum="52A603FD12B4176A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATK4</accession>
    <name>A0A1Y2ATK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_542516</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATK4"/>
    <dbReference type="FunCoup" id="A0A1Y2ATK4">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATK4"/>
    <dbReference type="InParanoid" id="A0A1Y2ATK4"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="115"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="290"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="420"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="910"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY25918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1179" mass="134036" checksum="99141F1EAB0E427E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATL2</accession>
    <name>A0A1Y2ATL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_544711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATL2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATL2"/>
    <dbReference type="InParanoid" id="A0A1Y2ATL2"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="11">
        <location>
            <begin position="66"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY25275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="429" mass="45869" checksum="A91F143640014B9C" modified="2017-08-30" version="1">MAAVPISSYARPPVTQLPAVVPAGSSQVNVNVGAAPQQPRPPAPYKPTTLDIRAEEDAARRLNAGRSQVGNTGYGGANSRARRTDLFDRDTLRRTVNTIGADLKLEFDEEALSYLAVATETRIRALLSQSTLASLHRTSTSHIHTPPFQPASTSSGPPKPGKPIWSHRINSDVTAVIDALNRQNKDAEQTFRADRMNRLARETEAQRIKERLALPAESENIAGPSTSTAPSGTGSNDVSTPTKASTSTATSPSGGTPTFGAVIEPKATKRSTKKGANLTPDGQHKMSNMTSMKWAGNMKSYSWLNAPNVSSPLAGKKRKTKASDQTAEPTKPADGEKSEDVSRKPNGDAEEGRVKKKAKNGAPLTRPSRRSVVVDKDEKGEEKKVTDDRAVTLVDLLFVLERDGLGRGMGTADEIVTKVQAMGGRFEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU73</accession>
    <name>A0A1Y2AU73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_541933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU73"/>
    <dbReference type="STRING" id="71784.A0A1Y2AU73"/>
    <dbReference type="InParanoid" id="A0A1Y2AU73"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="235" mass="21416" checksum="E5C638E4ED9FBE0C" modified="2017-08-30" version="1">MGILDKIADKVGGNKGNQGGDDYDNQQSGNFSSGQGGQGGQGGGYSDDSYNQGQGQGQGGQGGGFGSGNDSYSQGGQGGQTAGGFDGQGGGYSDGNMGSNVGSGGGLNSSDNYGSSGNDNFSSGGGGQGGFGGGQGGYGGGQGGGQGGFGGQGGGLGSGGQDNFDSSNQGGGGGFGGGGDSYGQNQGQGGGNFASQGGDDQGGYGGGGAVGGDNYGSGGQGQGQGQGGFGGSDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUD9</accession>
    <name>A0A1Y2AUD9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase, V0 complex, subunit E1/e2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_271663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUD9"/>
    <dbReference type="FunCoup" id="A0A1Y2AUD9">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUD9"/>
    <dbReference type="InParanoid" id="A0A1Y2AUD9"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="72" mass="8086" checksum="FA00261861B1CF5A" modified="2017-08-30" version="1">MGFSHVVWVAIVIIAIVVVGWVVTPRGKNQTLIRTSIALALTCCYLMWAITYLAQLHPLIRPRRGNLRVEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUV1</accession>
    <name>A0A1Y2AUV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_541376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUV1"/>
    <dbReference type="FunCoup" id="A0A1Y2AUV1">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUV1"/>
    <dbReference type="InParanoid" id="A0A1Y2AUV1"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
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                <person name="Labutti K."/>
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                <person name="Spatafora J.W."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="398" mass="43257" checksum="47F5F2D3C04DC117" modified="2017-08-30" version="1">MSSEPPSSPVSYGSHQDGSSQGSLPEVDVASAPDRSYLVSFGPDSCLILGGDTTILEEFKGKNIRAIAFTKGFLTQLGVHDDSTTELPSPSEQVKTFTRLAALANSVPPTDDISNPAFFPSIPGLTDHCEDDFDPDKLMQSSTGTFKTCTRDAIAQHDPLTCTLMSVLTDNPTISRLTVPGTFPGIQPLIAMTMKNAPNLTNLAFDGLGFYPSEVTQLSTLIKRHQSTPSRKITLEFGDTARRPFDEATGEEAKKAFEVYGELVALVTKSEFDPCDRYIFWNVPHFLIGDSNQGPPGFKIVTQGEIESDSNAETVSAYLMTGPMPLTNLDPSQFASAHRVVRDPETDQKEMEKFVIEWDSCVNPDIYKAQPSQRASMPKLEFRHGGSISSSCAALVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWN6</accession>
    <name>A0A1Y2AWN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_539428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWN6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWN6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWN6"/>
    <dbReference type="OrthoDB" id="428768at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="143" mass="15280" checksum="5E05FF93B865CE8A" modified="2017-08-30" version="1">MSKSDTMGTAATITGQCLCGAVTMSMPIPTSEATQICHCIDCRKSTGCLAIPLIRVPLTSFHYQGEISTYYAPGLSGASVGRVFCLICGSQLWDTSSVETDKIWIKGGLFPPGSIPIPTLEIFAKDMEAWEIPIPGAHLVQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWP6</accession>
    <name>A0A1Y2AWP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_539555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWP6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWP6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWP6"/>
    <dbReference type="OrthoDB" id="3345971at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="555" mass="61513" checksum="ED2CEEF4F3A568C7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX14</accession>
    <name>A0A1Y2AX14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_469840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX14"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX14"/>
    <dbReference type="InParanoid" id="A0A1Y2AX14"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="320" mass="35663" checksum="2C20063620F05861" modified="2017-08-30" version="1">MVRTVVIKEPLLKLSCALGEGCIWDTRKQRLFFVDIDERKVFTYEPRTGIVGYQTFDRKITALALLEQDDGVLGTAEDGMIHIPNTSLPFPPTGENMPYKRLPVNITPPKGFNRFNEACVDPTGTRFLCGTMGDQDRWDSAREVGGTMYALQSDGYGGLAAPLVLDNITCSNGMGWTEDLKTMYFTDSFRKEIANFDYDVVTGVMSNRRIFNNIDEDDMGWPDGMCMDNEYGIWSARWGAGKVIRFAPDGQMDIVIEFPKALNMTCCIFGGKDMDELYVTSASAATSGDSVKDFPDSGHVFLVKGLGFRGPERTRFKGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXH7</accession>
    <name>A0A1Y2AXH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_539695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXH7"/>
    <dbReference type="InParanoid" id="A0A1Y2AXH7"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000394">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="465" mass="50975" checksum="1954C443C7B1F3CA" modified="2017-08-30" version="1">MSILVDDKQDLQHVEDGSGIQDDDLRSFEYVSGTVEEKNLVRKIDRHILPMLWLMYVFNYLDRTNIGNAKVGGMEADLKLTSSDYSLVLSIFFVGYLLNEVPSNMILSRSKPSLFLPTIMVLWGSMSIGAKGVTSLGGMVAFRLVLGLVEAGFFPGVMLLLSCWYKPAELSKRIALFYTASLVSGAFGGLLAGGIIGGLEGVGNTRGWKWLFIIEGLCTVCIASVAYFVLPNFPTTTKWLTDEEKRLAVYRLQVGPEQVDDMTHKQAFIEALKDPKTWCFMIIYNVLNSVGTISYFFPTLMKALGYTGRTAQFMTVPIYVVALVVSVTAGWNADRTRQKAYHVLAAACLAVVSFVVCVAVHNNAARYAMICFGGAGVWTAVPLFLSWMVTMFDGREKRAISIALINGVGNLSSVYGSFFWPATDAPQYVMGFSISTGLMALAGVLVFVAKWKINDRGVAGIPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXJ1</accession>
    <name>A0A1Y2AXJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXJ1"/>
    <dbReference type="InParanoid" id="A0A1Y2AXJ1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="167" mass="17186" checksum="D67D4B7482B341BC" modified="2017-08-30" version="1">MENGYDSSSGSECSARTTPATTPPTASHSEFGENDLTQLTRVLTVLLRATGSAATGLASSRESVSEVPPGNESLHPSLRTIDDGSLRVPPNSAKHSNPNSTPTTNGTVASTTGNRANTSSTTSTMVNGTSAHSTTHPSVSNAPTTQSSPLPQLNAMPIFYPVASNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYX5</accession>
    <name>A0A1Y2AYX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_537869</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYX5"/>
    <dbReference type="FunCoup" id="A0A1Y2AYX5">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYX5"/>
    <dbReference type="InParanoid" id="A0A1Y2AYX5"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="210"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="515"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="703"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY27674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1169" mass="130498" checksum="F80B857F5701A40C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYY8</accession>
    <name>A0A1Y2AYY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_599510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYY8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYY8"/>
    <dbReference type="InParanoid" id="A0A1Y2AYY8"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32655" checksum="D606A501DCC19F0E" modified="2017-08-30" version="1">MPIATPRQLYGSINFTLRGEELDHDPSVYETTFDPDRPRPQKTLVVPVNDLRPELARGGLSVDSQVKSRGWAVSTHESEWVDQIGTEAGIEKYLEESAELIKKELGATRVVTWNSTCRKADDRKEDFVPRQEEPEKGFVPTARIQPPAARAHVDQAPEWAKKVVEMATGEDPDTFKRSMIINIWRPLHGPVTNAPLGMLDFPTASADDFLLGMSNFGNGLRIAHSPGQKWYYVRHQMPNEIVYLMCYDSTTNVCAGHTAIEVGEQDRQGVDEALIKPRESIEVRMIAVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ41</accession>
    <name>A0A1Y2AZ41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_217417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ41"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ41"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="314" mass="36442" checksum="DED78BCE35D9AEAD" modified="2017-08-30" version="1">MEEHYIWIWICHRQEDEREERGKEGRGPLMSLLERTTFMPSTRLVLELFDHSQTSFNRLALTSLFTMYPSYHIPLRSQSRSSQPRPTPSELQAPRPRAAVAFPCDSAQNQRTMSDYHTTRDRHGTHRREEAYQQQQQRQPITTDVPSRLNEERRYRHALPIPKPHDGLQDTKARSRTSVYPLDVPSSERHHHRSTGATPTRDVIKDIIRDVERGGTRSERNRAREESKFEKQCKAFVDDIEEDITCSVCMDIMWVELQVGHLAHAALGSDRTSSFHVVMQCVAHVSPLGYAVDMRTTSRSTALNVDKRCLVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ90</accession>
    <name>A0A1Y2AZ90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CND01650-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_536641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ90"/>
    <dbReference type="FunCoup" id="A0A1Y2AZ90">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ90"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ90"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000223">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="66"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="191" mass="20499" checksum="4A7F4743462A153D" modified="2017-08-30" version="1">MSASTIVIPGQPLPANLIAPPLPQCGAGCYEYQGRILSSIIGRPRRIGAVVSVVGKEEAANVPDIDSIVIGTISRVTPQQAHLTISTSNSRPVPESAEEFIGVIRIADTRLTERDKIKMGECFRLGDIVRAKVLSLGDARNYYLSTSANELGVIQATSEAGNPLTPVSYQEMEDVVTGTRERRKVAKPENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0U9</accession>
    <name>A0A1Y2B0U9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_535898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0U9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0U9"/>
    <dbReference type="InParanoid" id="A0A1Y2B0U9"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="4">
        <location>
            <begin position="77"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="335"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="573" mass="60926" checksum="67AF45560CC98614" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B193</accession>
    <name>A0A1Y2B193_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_534265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B193"/>
    <dbReference type="FunCoup" id="A0A1Y2B193">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B193"/>
    <dbReference type="InParanoid" id="A0A1Y2B193"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="126" mass="14243" checksum="4AA9D2BC4A4532EB" modified="2017-08-30" version="1">MKSFKLNPYDVLDVPYGCTDTDVKKSFRKKSLLIHPDKYKHPQGEEAFDLLKKAEGILSDSSKRGEIDAVMSHSRTLILKSLLGAGYSTSIPDDDPRLINLKPSLDVQIKTKAKEILIEDELTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1I2</accession>
    <name>A0A1Y2B1I2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_534288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1I2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1I2"/>
    <dbReference type="InParanoid" id="A0A1Y2B1I2"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="216" mass="24471" checksum="347B707795748CC3" modified="2017-08-30" version="1">MSHRQETIRAAEELVKAHMARYDPSHDWHHVNRVRNTAIRIASSLDPRPDLLVVELAALFHDLTDSKYDPNLPLEEVLLTFLKNPSTEFTLSASQLGLVLMIVPNVSWSKETKLRAADLWKGWYETCVELHCVQDADRLDAIGAIGLLRCAAYSGAKGVRLLYEGGHEGRRDDSAEGHFEEKLLKVRDRMKTIPGRDEAESRHTTVRAFEKSPIMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B254</accession>
    <name>A0A1Y2B254_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_187371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B254"/>
    <dbReference type="InParanoid" id="A0A1Y2B254"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="37"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="561" mass="62093" checksum="3BBF37589A569C5B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2A4</accession>
    <name>A0A1Y2B2A4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_180451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2A4"/>
    <dbReference type="InParanoid" id="A0A1Y2B2A4"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="742" mass="83004" checksum="E7090DDF2BE8AA6C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3H5</accession>
    <name>A0A1Y2B3H5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_176746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3H5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3H5"/>
    <dbReference type="InParanoid" id="A0A1Y2B3H5"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="386"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="907" mass="99133" checksum="DB8D0E5ECECCF2A0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3M5</accession>
    <name>A0A1Y2B3M5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_532390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3M5"/>
    <dbReference type="InParanoid" id="A0A1Y2B3M5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="299" mass="31628" checksum="A7C4BF7975E4CE52" modified="2017-08-30" version="1">MSTAISKLMWWRKPNHKDSESAHELLWRPESSLRSTESTEGIGDFQSSVPNDSYKSDDETIRPVPGDPSHPPPPYSQSSLNAYNSYGPSQYSNWLSNPDNPVSSTQLVSYNPSYMTPVAAHSTPDGWTGRLRSKLSNWWSHGGSMPPDQLTPLQKRRRRFKRNCTYIGITLLIVTCVGVPVGVDVGLRNRHRATSSALTGPNVSNAPPPPLSTASGSHAATGSLGAGTGTVGINTASPSTQTGHPGSSPGSTSNSQGGGKGNKGKGGKGGKGGHGRDYDSEVNPDLSEATSLYDGLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3N1</accession>
    <name>A0A1Y2B3N1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_505572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3N1"/>
    <dbReference type="InParanoid" id="A0A1Y2B3N1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="225" mass="24695" checksum="94D8B938AB703750" modified="2017-08-30" version="1">MLLELVERQVERRGGDSVSIAVSCRSVFEARSIILSFPLDLGIPSLNCPDGVQGLDKSERMLALYKTSDDEKEKKKTPAGVTENNDGEFPQRARVSLYSVAFLLVPLRSLNLPSPTITETGPHVWGKGSLSSSMKNNLFHGETMPHPYLKREAIKYGNSGHLGEMSQTLGYCESISLSTGITIILLRSNTGHLIVLYKHDGLTCILAQVGQAIDSRNLNPKVERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3S7</accession>
    <name>A0A1Y2B3S7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_177579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3S7"/>
    <dbReference type="InParanoid" id="A0A1Y2B3S7"/>
    <dbReference type="OrthoDB" id="2587170at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="132" mass="14713" checksum="F36BF45DFF699FDC" modified="2017-08-30" version="1">MRISGPLTISWLLYISMSISFTLLTHAVVLPTTTTLPQRPLIQNLPNICPALSVSCVKDGDWRHPIGSLGSKPFCRQGIRCNQCEGHKNTRECNRTFEACQGITVWCGLVVNVFDEAKTITYSIIKHSSIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B466</accession>
    <name>A0A1Y2B466_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B466"/>
    <dbReference type="InParanoid" id="A0A1Y2B466"/>
    <dbReference type="OrthoDB" id="2568061at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18369" checksum="A6FD623737FACB01" modified="2017-08-30" version="1">MVSLAGLKSPLMGLLLAVSYSSMVIDIIMITKVHADQNDYGAYPPAVVSMLVAAICQFLYCLAYFVRSGKGVLFKASSVAAALCFFLCFQVGSVAAATALRHHKKYCPPTASNGGDCSGVLRGTEGLGFAIVALNLIVIGFLAALVSKHGAWSDDLHNIPPIALPNADMEKAPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B558</accession>
    <name>A0A1Y2B558_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BCR39DRAFT_530336</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B558"/>
    <dbReference type="FunCoup" id="A0A1Y2B558">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B558"/>
    <dbReference type="InParanoid" id="A0A1Y2B558"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002669">
        <property type="entry name" value="Chromosome transmission fidelity protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="18"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="136"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ORY29962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="866" mass="96387" checksum="B39CCFCDDBEA9182" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5K0</accession>
    <name>A0A1Y2B5K0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein CtaG/Cox11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_530347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5K0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5K0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5K0"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="229" mass="25600" checksum="CFF10D4629C123BA" modified="2017-08-30" version="1">MDSARQRVYNERSKKSRSLLMYSIGTILLSVGVTYAAVPLYRAFCSATGFSGVPVTDPTRFTPDRLYVTPETAGRKRITVHFNAQAADSLPWKFEAQQRNVKVLPGETALAFYTATNMGEEDLIGIATYNMTPDKIAPYFAKVECFCFEEQRIRAGEQVDLPVFFFIDRDIVDDPALDGLDDVVLNYTFFKARRNQKGHLVPDASEEAVLQSQGFDKYEHAPPVASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5S0</accession>
    <name>A0A1Y2B5S0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_530743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5S0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5S0"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY30036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="260" mass="27397" checksum="42CEFD7C855D6197" modified="2017-08-30" version="1">MSPQSALIIGASRGLGLALTKHYASITGPSNVFASVRSSPKPGEFPQGVNVIEGVDVSKPDCGDKVVNGLKGRSVEVVVVVAGLLKPEKFGESNWEDEIAMYTICAIAPVKLVEALVMSSSLAPAAKIILLTSEGGSITLRTQGEGGGMFGHHGSKAAGNMVGRLLSFDLQERGIPIAMVHPGFLKTEMTKNAGMEEFYDQMGAVTPEEAAIPFAEFVDKLDMSMTGKLWAPMGARGIGNAEEVMGKSVKDHKGPLELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6L6</accession>
    <name>A0A1Y2B6L6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor Pcc1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_480934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6L6"/>
    <dbReference type="FunCoup" id="A0A1Y2B6L6">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6L6"/>
    <dbReference type="InParanoid" id="A0A1Y2B6L6"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011470">
        <property type="entry name" value="PRK14887.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="136" mass="15077" checksum="BD94228E9A0116A4" modified="2017-08-30" version="1">MTSIIPSDPSSSQWHTVTLQIPFYNPEHARTAMRALQVDREQNATFVQRSISTQEETLIVEFKATTVRLLRLATNSFLSSVDLVMRTMEEFASDPDIPLPTDQELEDERVRANRGQDKGIELKGDGVGAGGGEEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B845</accession>
    <name>A0A1Y2B845_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_101121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B845"/>
    <dbReference type="FunCoup" id="A0A1Y2B845">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B845"/>
    <dbReference type="InParanoid" id="A0A1Y2B845"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="337" mass="38143" checksum="50B7896A1F3A1FF9" modified="2017-08-30" version="1">MSGEHEMKYVNLGKSGLKVSKLILGCMQYGSGQDWMIPDHDEGIRQLKYAYDQGINTFDTANTYSAGESEVILGKFLKQHSIPRESVVILTKTFNTEGTLEEKGPAGWINQKGLSRKRIFASVKGSLERLGLEYIDLLQCHRFDKETPIEETMQALHDVVQAGWVRYVGMSSCWAWQFQIMQQYAINNRLTPFISMQNQHSAMYREEEREMMPMLKHFGVGVIPWGPIAAGLLCRPHKEMDSTTRGAGRPRDGRGEQSGDKLIIDKVEEIAKKRGVPMAEVAVAWSCGSEWVTAPIVGIRSTDRLDELIKGMNFELTKEERKSIDELYLPVKVRGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B977</accession>
    <name>A0A1Y2B977_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_526462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B977"/>
    <dbReference type="FunCoup" id="A0A1Y2B977">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B977"/>
    <dbReference type="InParanoid" id="A0A1Y2B977"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="510" mass="54868" checksum="9AC8135118AC6356" modified="2017-08-30" version="1">MKFPWSGKVQLEPTTGENAKDSNVIERKIGLSKVGTIFASGASLFSDGYANAAIGPAGSIIKTYIYPDKFLKGSQNGSLLSSMAFAGIIVGQLSFGYISDKIGRKFGMLLCTGIVFVFSALQAASKGPGEQGTINALIAYRFFCGIGIGGEYPTGSVAAAESTENPGIKKNSQQRLFVLATNTMIDFAFVISYFVCLVCLWIFGLHHLNAVWRITLGLGCVPPLFLLYFRLKMVEPDAYKHNSMKNAPIPYLLLIKRYWLRLAAVSITWFLYDWITYPFGIYATSITDVVIPNGTLYETIGWGCLINFFYVPGTVVGAFVVDFIGPKYCMITGLCLQAIFGFALSGAYDKLVPNHIAGFAIMYGLFLSFGELGPGNCLGLLASKAIGPTAARGQLYGIAAAVGKVGAFIGTYTFPQIQASFGDVGTYGYNTGPFWLGSGLAIASAVITLIFIPNIKPDEMIREDAAFREYLAANGYDVSQIGIKDELFQVSVQDVSEGVGADADDKAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B979</accession>
    <name>A0A1Y2B979_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_527991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B979"/>
    <dbReference type="STRING" id="71784.A0A1Y2B979"/>
    <dbReference type="InParanoid" id="A0A1Y2B979"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="410" mass="47380" checksum="F1246F74631881ED" modified="2017-08-30" version="1">MRPRWSVEPKIEDLLTVCGSRASISTYLNGSYNKCYKIEAESGPLLLRVGLPIDAPRKTESEVATMYYITQHTGIPIPRVLRYDATNHNVPHFPYISMEFIQGRCLEELWHELSMEVKELIVRQLARSEAEVFDLEFHFIGNLYFEPHSDSGHSKASSAKDATTSDGTFRARHPPHPRYSKFRPGPIVIADSPDLSSRLPRGPYDHGQDWLRDRVECCVFNFEQTLLKPDVSDEDLADIPSILTFARLLLEVIPKVFPKGDSPESTRIFHHDLHARNIIVDQDNIVGLLDWEFVSIVPVWQFCELPRVLHGPDDVSKPERAHYYPYGSDTVAEESYYWDEVMQYERVHLRKVFIKEMEQLRPSWVSEFRRGSLKRQVAMAINYIERGSIYASHEWAGRLVRGETESYPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9Y8</accession>
    <name>A0A1Y2B9Y8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport protein Avl9-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_479804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9Y8"/>
    <dbReference type="FunCoup" id="A0A1Y2B9Y8">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2B9Y8"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="92"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="684" mass="74823" checksum="16274CDAFC4E7E8C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAB5</accession>
    <name>A0A1Y2BAB5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Argonaute-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_527853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAB5"/>
    <dbReference type="FunCoup" id="A0A1Y2BAB5">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAB5"/>
    <dbReference type="InParanoid" id="A0A1Y2BAB5"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="309"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="595"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="950" mass="104593" checksum="C4C539D9FFFD1FBB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAQ8</accession>
    <name>A0A1Y2BAQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAQ8"/>
    <dbReference type="InParanoid" id="A0A1Y2BAQ8"/>
    <dbReference type="OrthoDB" id="2571901at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="362" mass="39059" checksum="0BE5B6874F6A0570" modified="2017-08-30" version="1">MSIRSLVAGPSRIAQVAPTFLAGSSRVSRRNLTYPHPDLDPSKGTTELYVKFLNKGNTMLDILAVIRAIESKLGPSVFLHVPKDFETLQTSTIFFLHLLRPAQLDRHLLLEVPSPKISRESNHLGGPSLADLMSVLRSNPLDEAGAEGEPPIHVRVEPVPLSGRRKASKELHVQHISSADTPALRAEDKAIVEALRRFEGGFYGGFQGIADDFAHLAGDSATSTVQSISTRTQNTASDRASTRSTSSERSERSSPLTSVTGSPSSSNTPTPKSSEPRPRRPSRAKTSSIPSPELNRDTAQDDEKPKRRRGTKLKQDSTSQTVVEKVLDASLAAAEGEMKVSQETQEAASAVSEKVQQAEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAR9</accession>
    <name>A0A1Y2BAR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BCR39DRAFT_524756</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAR9"/>
    <dbReference type="FunCoup" id="A0A1Y2BAR9">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAR9"/>
    <dbReference type="InParanoid" id="A0A1Y2BAR9"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 21" id="KW-0378">Hydrolase</keyword>
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            <begin position="32"/>
            <end position="384"/>
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            <begin position="486"/>
            <end position="522"/>
        </location>
    </feature>
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        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
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            <position position="220"/>
        </location>
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        <location>
            <position position="244"/>
        </location>
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        <location>
            <position position="101"/>
        </location>
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            <name>substrate</name>
        </ligand>
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        <location>
            <position position="139"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="140"/>
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            <name>substrate</name>
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        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        <location>
            <position position="189"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
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        <location>
            <position position="218"/>
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            <name>substrate</name>
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            <position position="220"/>
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        <location>
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            <name>substrate</name>
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            <name>substrate</name>
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    <sequence length="547" mass="61216" checksum="934A00850B4FED1E" modified="2017-08-30" version="1"> </sequence>
</entry>
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    <accession>A0A1Y2BB01</accession>
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                <person name="Dannebaum R.O."/>
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                <person name="Labutti K."/>
                <person name="Haridas S."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
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            <begin position="366"/>
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        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="427"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="75"/>
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        </location>
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        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="88495" checksum="882EB117F01FA494" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCM8</accession>
    <name>A0A1Y2BCM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_523044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCM8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCM8"/>
    <dbReference type="InParanoid" id="A0A1Y2BCM8"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="330" mass="34896" checksum="B6CC956E2AABACF7" modified="2017-08-30" version="1">METIGILYPGAMGSSLARTLSSRLPHLTLLTSLSNRSASTVSRAESSGLTNVPLSELVSRSDIILSILPPSSATDLAKEIISHLPSNRSKPLIYADLNAVSPGTTSKISALLLEHDIVFLDGSVLGLPATETFDPKIYLSCRAEFESSLNEVADVLSGGSPGKGLAIHTMPGAGEGAASALKMCYGGINKGYVGLASLLVMAANAHSKGTADALLDEFADSKTAALEGFSRSFPDMIGKAYRWVGEMEEISSFINTSLSGNDSSDLARENARKVAETFQGLAKVFQRVADDVRDDEEEEQGDSAGKEEVDKLLDWGKRGGEAVKRKKQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCQ3</accession>
    <name>A0A1Y2BCQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_523168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCQ3"/>
    <dbReference type="FunCoup" id="A0A1Y2BCQ3">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCQ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BCQ3"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="332" mass="37030" checksum="CC77C3F37D978820" modified="2017-08-30" version="1">MPATTTLAGKEIGRVGLGLMMLTWGGDLPTDEESFTAIRTAVDNGSNYLNSATFYGHPENHEAGLQLLNRFFTAYPEYADRVILGVKGGIFYEKRMPSGELEFLRSDLKRAYEHLGDKKKIDIFEMARVPNDLPIEETIKNLVILKEEGYFNHIGLSEATADTLSRAHAVYPIACVEIELSLFYLEPSVLETTTLAEKLGVAIIAYSPLGRGFFSGKYRSIDDFPEGDIRKVYPRFQGDNFKKNLELVDKVAELAKKKGSSTSQLALAYIMHISPVVVPIPGSSNPKRIIENIEAANIELTDEDVKQIDEILKTFVTAGDRYPDYAKSFLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD85</accession>
    <name>A0A1Y2BD85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_557363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD85"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD85"/>
    <dbReference type="InParanoid" id="A0A1Y2BD85"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1192" mass="132356" checksum="C15CCA5F6FBB60DE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDF4</accession>
    <name>A0A1Y2BDF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_522914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDF4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDF4"/>
    <dbReference type="InParanoid" id="A0A1Y2BDF4"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="269" mass="29602" checksum="ECC7FFC18B31998D" modified="2017-08-30" version="1">MSGIAAATAPADGKSSSSKEPHKMRITSGGSIASYVKFALTFLDENPHRPLILHTIAPPPPPPPTTTTPTKGTKPSKRPTSTLTPSLLNTPRLISVVELIKRAYMQRIESPESRKGKERAIGIWQYTESGLLPFVNLEREKGLQVEGDTETETALERVLGGKTQPKMTHQPFLQITLSTSPLGWESRRGVTCQYVMVRRRRPRNKVPPADIMENEPGEVEKPLESLGVADVDLGTKINRDAPTAAMEKKRKSEGSQEGVVKKRPKGKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDG4</accession>
    <name>A0A1Y2BDG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_522132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDG4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDG4"/>
    <dbReference type="InParanoid" id="A0A1Y2BDG4"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF53">
        <property type="entry name" value="BETA-1,4-GLUCOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012576001" evidence="2">
        <location>
            <begin position="18"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="702" mass="77899" checksum="4123B8613FC18B6C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDU3</accession>
    <name>A0A1Y2BDU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_522287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDU3"/>
    <dbReference type="InParanoid" id="A0A1Y2BDU3"/>
    <dbReference type="OrthoDB" id="2570610at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="356" mass="40687" checksum="895A43ED25D3B318" modified="2017-08-30" version="1">MRLNLDPVKHTDLPAAFRLVRQVLKTQPRSFRDILSAGVQLYEAENPEFAQQRRRAEAQQLGASTSTSATITKAAPKGSAMARMLALSKKGAEPKMQRKLELEVEEHAIPPAHPWVSTNFFKRRILPVLSSQNLIVLRSQPTSSLAIRRNEPRRSKYEWQLAPKTRLHNTDAHWEKLVSGEHPGAVGGEYKAHLEQEQALRREQAFNEKRANRTDRDVVQWMERPPELTTKLQRMHLSTRRRRNRDGKEMRAIMRRYEYDLERGLDLNSEEGKQTRLAVDLALRRLSGYEGSKRQGKDKRDEIRKRRKLAAVRLAKGTKKVRASVGDLKGVKAVDTHAHGVVSEEAKASENVNINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE99</accession>
    <name>A0A1Y2BE99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_521481</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE99"/>
    <dbReference type="InParanoid" id="A0A1Y2BE99"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37307" checksum="126BC8A402574336" modified="2017-08-30" version="1">MVIATISPPVSSIMRPPPDPSQCSGTHDVPTLVLSLGLCTGLVISYLPQHIRIIRAGTSEGFSPWFLLLGATSSASGMLNILIVQWPLFRCCRILSSGRCFESLLGFYQVTLQWLLFTIILILYLYYYPAHLKYQRTLPFSTSQNGYGTTGSNGESPEPGESNIVQENVNGVSKAVKARLSTTPEWRLAVTLGIVVALHLGLLLLLSLALLLVLPPTSPPHPLLQYLATFLGVSALILSVLQYAPQMYKTYRAKLVGALSLGTMAIQVPGSVLFVLSLVFRPGTDWTSWLVYAVTGVMQGALLVICIIWKRRQRRLGIDDFGLPIPGGPSGETSALLPPEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF18</accession>
    <name>A0A1Y2BF18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_463559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF18"/>
    <dbReference type="FunCoup" id="A0A1Y2BF18">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF18"/>
    <dbReference type="InParanoid" id="A0A1Y2BF18"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002582">
        <property type="entry name" value="Nicotinamide riboside kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="30085" checksum="07C97F0A929DDCB2" modified="2017-08-30" version="1">MRRRLVIIGIGGASCSGKTLLAKHVRSVLPSGSTILHQDDFAPPIDQVPYSKKYGVQDWDDPPTCILWDEFRATLKYIRIHGTLPNLHTSHDHLNKQVELELDPMVKEAWRIEFQRFNAEMNGEGVEVVWFIVDGFVLYWDQQDVVDKLDIRIFLQVPHDLLKRRREERQVYVLQNPDDAAAGGVWSDPPNYFEEIVYPAYIKAHEHLFDNVETGQLKERWTDRLQVVRPREGAEEMTRVFGESCKGIIEACRQGKGTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFI0</accession>
    <name>A0A1Y2BFI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_520346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFI0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFI0"/>
    <dbReference type="InParanoid" id="A0A1Y2BFI0"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="72" mass="7897" checksum="F7D3E4089EC53783" modified="2017-08-30" version="1">MARPPSSGTDVALYFIALFIPPIAVFAKRGVGSDLFINILLWILGWIPGVLHAWYIITKTERPAGAPIGSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFJ1</accession>
    <name>A0A1Y2BFJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="14" type="ORF">BCR39DRAFT_520374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFJ1"/>
    <dbReference type="FunCoup" id="A0A1Y2BFJ1">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFJ1"/>
    <dbReference type="InParanoid" id="A0A1Y2BFJ1"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="84"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="406"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY33486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="589" mass="63134" checksum="89DB465CE64CE07A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFQ2</accession>
    <name>A0A1Y2BFQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_522357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFQ2"/>
    <dbReference type="InParanoid" id="A0A1Y2BFQ2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="60" mass="6992" checksum="6008AF7D908E600D" modified="2017-08-30" version="1">MNLDTSPDFVHFFLGFTGGVSILDLYCLFMYTFFDMIQLQLNPFSDFFFPFSLPHTHSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFR7</accession>
    <name>A0A1Y2BFR7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_522397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFR7"/>
    <dbReference type="InParanoid" id="A0A1Y2BFR7"/>
    <dbReference type="OrthoDB" id="2565180at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="825" mass="90484" checksum="7849C9E221F33C1B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGM2</accession>
    <name>A0A1Y2BGM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CTLH/CRA C-terminal to lish motif domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_517947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGM2"/>
    <dbReference type="FunCoup" id="A0A1Y2BGM2">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGM2"/>
    <dbReference type="InParanoid" id="A0A1Y2BGM2"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="9">
        <location>
            <begin position="163"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="377"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="377"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="435" mass="47866" checksum="2DFE4FB45CFF8196" modified="2017-08-30" version="1">MPPALSSSNPGLILEEPLIRTPYELLRRSHRSAQRQVEKDFTAISSALNALIKSYGGKTSEENRDTVVSKLDQAGERVRGLKRKLDDLQPQLEQPSPLRSRLTYLDNLSNPNKPADPKASDAPGDSTLDRYIIDHLLRSGRIKSADTLAAKQGLDDLVDVRLFSELARIESALVDRQSVTEALAWCGENRGTLKKTQNTLEFTLRLQEFIELCRRRDTVGAIAYSRKHLSTWASTHLVEIQQGMTLLAFGERTGVGAYRRMYDRARWMSVRDRFRKTFLDLYALPSQSLLALSLSAGLSALRLPSCVTHHSEKAPTTSPHIPLLPAAPPLHNLEDVLLLSPHSSFVPHLTAPIGGDPSTPATDLHTHPEAQVGNIDCPTCGPDVKVLAAEVPMSHHVNSTIVCRISGAVMDSDNEPLAFPNGYVYSAKVGPRMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGP6</accession>
    <name>A0A1Y2BGP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_517977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGP6"/>
    <dbReference type="FunCoup" id="A0A1Y2BGP6">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGP6"/>
    <dbReference type="InParanoid" id="A0A1Y2BGP6"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="32"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="703" mass="76830" checksum="0A7E4FF84F42CF7D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHL2</accession>
    <name>A0A1Y2BHL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_518310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHL2"/>
    <dbReference type="InParanoid" id="A0A1Y2BHL2"/>
    <dbReference type="OrthoDB" id="2581931at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="98" mass="9795" checksum="45AE0AC4E7870861" modified="2017-08-30" version="1">MASYNDTSVNPQGVEGAYAGVMNTTETKGGDTAAVGPDLLGDTGKEIAAKQNVIEGGPGIIESTELAPLGEEKVAADPGLASQATKIAKDAYNSVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI15</accession>
    <name>A0A1Y2BI15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD binding domain of 6-phosphogluconate dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_462793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI15"/>
    <dbReference type="STRING" id="71784.A0A1Y2BI15"/>
    <dbReference type="InParanoid" id="A0A1Y2BI15"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="3">
        <location>
            <begin position="174"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="380"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="3">
        <location>
            <begin position="470"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="599" mass="62204" checksum="CFE3709609230EC6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJF4</accession>
    <name>A0A1Y2BJF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_515479</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJF4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJF4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJF4"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY34902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="135" mass="15869" checksum="A60F1CB2EA369868" modified="2017-08-30" version="1">MSVPAGPSFSAAHRSYVKSLYRRILKNELDWVIRRDIWRQRAIEIRAKFDRNRNIADPRALALVLEQAEADLAKKLHPDPYKPPLFPEGTKWERNTPPKMFTKEEKEKAETYMRQFTGPFSDEWKEKAKAMGLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJS4</accession>
    <name>A0A1Y2BJS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_516204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJS4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJS4"/>
    <dbReference type="OrthoDB" id="2576477at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="402" mass="44723" checksum="00827BDCE6F63014" modified="2017-08-30" version="1">MTTTSTTNSSHSTSPPKVPRMALTRSPSDPMAAPQRPEPPPGQIYVLSADGSSLFLLDPSKPNRLEEPPPYAPFTAPSELSSPRSEHHSVQFPTITGTSSLLLPPSSANEQHHFRGRASTMSALADEAGPSRRPRYRSTVSNTTPISSRARLPSLEDLNVGAPDDESTPLLAHSVENGDARRKKRGLWSSIFCGEIEDQDTRTGFVAGWNRFWSPMGDKRYWRAMLHLWLLNFPIALLVWPFLVAGTLAGTALLITLPIGVTVWWLTLIISRSAARLETIMQLHFHGPLDDWVPPPTYHPIFYRIKERSVPSSPLAAQDELPPEIIWEKRFTKCSYAMFADHYSYSALSYFLLIKPVITLFSTIIILALLPVLFATIFGAPVYLRAARRFGKWQAGVAIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJU4</accession>
    <name>A0A1Y2BJU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of Vps4 activity in the MVB pathway-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_516214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJU4"/>
    <dbReference type="FunCoup" id="A0A1Y2BJU4">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJU4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJU4"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="274" mass="30256" checksum="6BA93A36DB52F5FF" modified="2017-08-30" version="1">MVPWNPARVKVQIRLSIQRLRTLQEKKSALAKKSRREIADLLIKSRVETARLRVEGLIQDDIYVELLELLELYVETLQARFGLLDSTSGTEPEASIADAVCSIVYAAPRTELKELQVLREMLMHKYGRAFSLALQPSDPPPTSVPPRILSKLALFIPSKELVDAYMYEIAKGYNVDWAPEPSSTSGEPVDGDIPSIVGKGDDDEDEDDDDAGNGGGDGGTKEAVALEVPPGELGKRKDVAVEKPAPVPAPSEAKLKKDEEEDLARRFERLKNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJU5</accession>
    <name>A0A1Y2BJU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_516269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJU5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJU5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="23666" checksum="517E051F2C1D6E3C" modified="2017-08-30" version="1">MSIKTVRCFSGTMTRTSFAETLVFSRDEGGTVSGGEYITGESVGSMGSETACESMSDEDVSSVGERNRSESEERGAANTVWVARVGSAGKPDDTSIRAAMQEGRIAEKDIDSIWGDFLNRMETISSTDRDLNVYSVIVSSDGGSRDWCLLLNPHEASSHDLDSTNINIEEQITQEVHDTLFTEGSRFNSKLSEIFAGDAHQKEFTATVTGFMNGELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJU7</accession>
    <name>A0A1Y2BJU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase III RPC4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_516248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJU7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJU7"/>
    <dbReference type="InParanoid" id="A0A1Y2BJU7"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="483" mass="52532" checksum="CCD8D674BF0C2075" modified="2017-08-30" version="1">MSGPRRGRGRPALIVAAQAEVPSPSAPMEITNSQPGTIDSGSARSTPTLPDSASVLSVGYGDSQAGDQPIQRMKFKPRVPIRRPKTEVDVKPEISEPSSSAARGGFRGRGRGGHLGRRGSPIKYSSTSTGIFSGNRISPGQRHTPIPAPRVGIFQQEAEQYSDGEDDSKGTSNGEGHIDIDQVSGMGESAPTSLYRDRTPHGGVKGKGKDTLSGREKIKRIRRVVVNDDDDVTMVKAERLSPVKSHSGLPERDDEVIMPDNDDDHDPNALGQRVRTFMRTGGIEDEVDGEQDVNEAQKVDLSESESEEEEEDLTGDFIQLEDGDPPEDKLFMFQFPHLFPKFLSSDPVDMTKDEKPDIKPDIAAAPSTKGKKKANLPPPEGRIGTMVVMKSGRVKMVLGDNIVMNVTPGVPPTFIQHLVHVDQPSKSLTVLGEVNTQYTVSPDIDRLLQDLFIIGGQTPGDLENEKRKRMVKLEPGLVKLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJW5</accession>
    <name>A0A1Y2BJW5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_462617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJW5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJW5"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17023" checksum="FD5111D76C30BA4F" modified="2017-08-30" version="1">MSQPLSTLPSPRRIITYHEPSGESAAIEEIVPMKVFSALNSATMFIQEDFPAQPDKTVEYANAVSPTFTLSSGVTCYFVDFKPNHHGPLHFANSVGESDMLEYIVITHGSLHLEIDNGQSWTVSQGDAAVCVANAHYWHNKTNEWARQSFAIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BK00</accession>
    <name>A0A1Y2BK00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_516706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BK00"/>
    <dbReference type="STRING" id="71784.A0A1Y2BK00"/>
    <dbReference type="InParanoid" id="A0A1Y2BK00"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="638" mass="71108" checksum="8F88BA997EC68427" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKQ7</accession>
    <name>A0A1Y2BKQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_509118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2BKQ7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012350054" evidence="1">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="291" mass="30807" checksum="4070E7699C7C8693" modified="2017-08-30" version="1">MLFIKLILSSLLFTVRAGPSVPRLVEAPAINGVFTGDLYQLGEHLGLGNISLTSFGASGSDVTKRDGGSCPVPDGIWNKFGAVLEEHPWAWVAVGVFAAPIVATSWYAAAAISVTAAIKAHRTMVATWNAQANQKRDGGIVVFAIDGALDPEGIINSGLGTTGIYQIDYSTGVIDKLGDLHTFSVPDAQAGRGKRYTSGSYVVATSYDGPIIAFNDQDMQGMVQDMLHAAWSGGSEACFSQSWCGNNGCEQLEMQVSSYNGVNIDNLWGNCCGINRNAQWYDFYGSGGTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLD3</accession>
    <name>A0A1Y2BLD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S9/S16-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_509975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLD3"/>
    <dbReference type="FunCoup" id="A0A1Y2BLD3">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLD3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLD3"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="360" mass="39785" checksum="7EA285CBFD5EF83E" modified="2017-08-30" version="1">MASTSTSTLRCLRLSSTSTPLSSLSHTFRRNASTDSYPPRFGTRDIDDIEPPSRPPRPSSPHFFSGRPQQTTEVTALEDLLNKTQRALRTAHVYPLPASLTMPQLPEVRWKTASELSQRFGRQVNNSVHRRVTTLLNELNRMRYLAEVGGRSQVAQKVSNTLDSYSRGSRYNSSLSSKDNSPGNQSGIDEFGRAQGVGRRKEASARVWIVPSQNASTFLDAPFEPFRPAENSDFTTSLTATSTSTLNGEKAILPTSEILINHLPLPAHFPRPIDREKVIRPLRLTGLLGAYNVFVLARGGGTTGQADAIAMGLARALVAMRQDAKDVLFAAGLLMRDTRMVERKKTGRPKARKKSAWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLG2</accession>
    <name>A0A1Y2BLG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_475657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLG2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLG2"/>
    <dbReference type="InParanoid" id="A0A1Y2BLG2"/>
    <dbReference type="OrthoDB" id="2384193at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="435" mass="49417" checksum="38874594581779C3" modified="2017-08-30" version="1">MGFSALIALTGLLFLLWHTWHYDGFKCLYNIRSDWFRTLMILILLVSIAFFCLATLVESYVLYDQYYVFLGTVTIPAPWQLYTPHSVKLWKASLWCLLVGWGFLQAVHMEEFLYWGYLMRSIRTPGGPRTSWLRSGFFKVWVAAFACSWALMIASLQIETHNLDMMRAYLFLIGSVISTVLALMSVLLCIVFPRFLTLVRQQGAGFEVLERLHFFKEANELRTVCRVCYALCFLILSTDATTPAQRINKSAFWADFLYTVGQLGLFASTCFSILILLPRNMGSESLPTAADNAQQPMVPYKLPHIGGGHIITEAQRGLWELGDRLNINRDALALTIPYLSSPGQEKDEGYELDESPRRLDIESSEPAARAEIQEDQAPFSEIADTRVRARYSEFPALPTVLQKFKSPFETAQASRRVSGPAQVFVQTTQTVHHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLH2</accession>
    <name>A0A1Y2BLH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">BCR39DRAFT_489157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLH2"/>
    <dbReference type="FunCoup" id="A0A1Y2BLH2">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLH2"/>
    <dbReference type="InParanoid" id="A0A1Y2BLH2"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="368" mass="40911" checksum="88D7F2326FEF5F1F" modified="2017-08-30" version="1">MPPTPCSLCQTARALVKRPKTGQQVCKSCFFEVFETEVHNTIIEGNGLFKRGEKVAIGASGGKDSTVLAHVLSTLNQRYDYGLDLYLLSIDEGITGYRDDSLETVKQNQVEYGLPLKILSYDDLYGWTMDKIVSQVGRKNNCTFCGVFRRQALDRGAAQLGVDHIVTGHNADDIAETVLMNIMRGDIARLGRCTAVTTEGEDTIKRSKPFKYAYEKEIVMYAYFKKLTYFSTECIYSPDAYRGHARVFLKDLESIRPSAIIDIIHSGESFVLQEGVQRGMKAMQTCKRCGYISSNDLCKACALLQGLEAGLDRSALRQTQDSTTLAPDGQRTIPKYDRHATAFELSTPPKIELHATEGIERAVKAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLL1</accession>
    <name>A0A1Y2BLL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_511337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLL1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLL1"/>
    <dbReference type="InParanoid" id="A0A1Y2BLL1"/>
    <dbReference type="OrthoDB" id="2552152at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="43894" checksum="F10572D8D922C167" modified="2017-08-30" version="1">MSDSGAASVPLSKDRPEPRGRKPNDHLPPSRAREVQRAFRLRRAEHLAALEERIALLESENGQLRALLALPEADRPKIGSGPTGRGKSLREGGVPMSERVRARKEARARDRLARGLPEKVDDSDTDSMRDSESPGRSINDHSHSHSHSHPSTNTSNNQMNHQQQQQQQGLPLFSQPSRDAPPAFNYSLPMQFNLPVSPPDHSFGDFGGHLDSSSIFKSPPPPPIQTAPTPGFSGMFSNLFDEPSSSSSTTAPPTRSPPPPAQQQQQQQTTPNQPELLTRLKACCHLSDSHVVNDPGLLIFATRLCQSFPCQFAGVHPDTVGASDSDHFALEESWRALKAQLDPGGDADGENRINTGRMAAELVIRAAHSRGQSGWIICRYREGMSIKRALIVGLVNGLGGKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM41</accession>
    <name>A0A1Y2BM41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_512454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM41"/>
    <dbReference type="FunCoup" id="A0A1Y2BM41">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM41"/>
    <dbReference type="InParanoid" id="A0A1Y2BM41"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000513">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.3, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="185"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="379"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="466" mass="49339" checksum="2E6EF5D9B3530C26" modified="2017-08-30" version="1">MSQPHEHEEEDPVLQDEDIVEVYNEEDDDNVPMDEDDDDNAQYDGEIIIGGPGPGEEEEMMDMERHEDNSWGVTALHGAQQSIFTLSLHPLFPNPPIAVSGGEDDLGFIFSPIPAQSAGGVNSETFPPVRLTGHTDSVVAAGWSFDGEMVATGGMDGRVRVWKRVKARRGSQEVQAESADSWRDWEFLTNLETGSEIQWVTWHPKGNVLSAGCEDSSVWLWNLPSGNTLTVLSSHTLASTAGLFPPPTARQLLTSSLDSSLILWEISSSAPAFKSSIFTAAGNPELDPAQHGITSLAVAPNGQLAAVGGAGGRVRLVSLPKGDTVGRLEGHAERESVEALIFVDLLAGAGGGKGVVLVSAGTDGKGFVWDVATGRVRAELVHNEPITSLAAHPAPHLHLVTSASADGTLKTWDVRTGALVAEHKGHTGVVNGVAVASYPLQEGEEGKLGQVVVSAGDEGVSLIWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMI5</accession>
    <name>A0A1Y2BMI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_513004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMI5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMI5"/>
    <dbReference type="InParanoid" id="A0A1Y2BMI5"/>
    <dbReference type="OrthoDB" id="3632757at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013028184" description="Peptidase M24 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="205"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="451" mass="51264" checksum="3B8200B7E6702B43" modified="2017-08-30" version="1">MRFSLLILALTSLLGVLAKQPTAHYRDLPTLRKQDELEKAWVQKRYELIPSILKKYGYDAWILSMREYAEDTAFRALVSSTTTFSARRRTLFMFHTDPSVPSPFHYVELKEELWEALNETLHKVDPKKIAVNIDEDMAFSDGLHTGEGRLLLSKLGPYADRVSSERGIGVETVAARVGGEEQLSMYKLMMENVWAMVQEGFSERAVEVGKTTAEDLEWWFRDVMRWRFGTGTWFPPTVNIYRSPAEPSAEEDPYMRPGDLLHVDIGITAMGMNTDTQHLGYILRHNETSPPASLIKGLHDANKLQDFVRKQMVPGRTGDEVFAKVSADMEKAGLKGRIYSHPIGDYGHSAGAIIGMANNQGPISGGGQNKVLENYWTSVELAGVTYIPEWGIEQAFELEEDVYWDEKTKTFEWVFGQQTEIHLVKPKYSHKKHSWLTLAAGKLGWEVVKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BP27</accession>
    <name>A0A1Y2BP27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_512977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BP27"/>
    <dbReference type="STRING" id="71784.A0A1Y2BP27"/>
    <dbReference type="InParanoid" id="A0A1Y2BP27"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="1">
        <location>
            <begin position="225"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="465" mass="52180" checksum="95BE4946A11D4EA0" modified="2017-08-30" version="1">MPSTSPSRLKPRRKSGGMIKRKSPTLLLVLVSLMGAAIFWASTSSSSPATRVFSTKNYSATGQASVYVPINGEKTNYVNGIAGTTLWENIYLRNGTWYVVTSHPQSMPEVGTILCAEPLPERKHIPAGPDRFQYINPSQASEILGKVAVRKAGLSMFFNDEPGPNGQSFLAHYFHSEVFLSAWRLVTSSYGTVPLPERLMYRTVPEDWRDKAGLTTWFQQSVMPNTIIEDAPVWKDRKASQTTFVFDRLVIVDRFSAHMFGHDVGLWNKMTADLPTLPVPKDWMLPLRNSLKNFVLAQGCELEREHARVPILTYVNRQMTSRRLEAEDADLLLESLNQLHAKGEVEFHNAIMENMDRADQFCLALKSDILIGVHGNGLSHQLWMKPGSAVLEDYALPADLMGHEYYAIHNDTYLPRSEWILSDGRAMQQGKGFHSSNIRTHGPYIASLISRLAKDRSSPVDKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADT0</accession>
    <name>A0A1Y2ADT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII28-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_554999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000128">
        <property type="protein sequence ID" value="ORY20672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADT0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADT0"/>
    <dbReference type="InParanoid" id="A0A1Y2ADT0"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY20672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="235" mass="25752" checksum="346BF38069561D34" modified="2017-08-30" version="1">MSHLALPPASSVASGPSQPKKRRKPRPSSTTHPTRDLSRALDADDDVSEDELVAAPQKRLRPEVEVEVEVEVDEESGDEEEVDEEPKGGKGKKEGNGSREKVWRARRGDQLLLREQLDPDQARRYDAFSTVVLPTQAITKLNRELLDQRLNSHLAKIVGSLGKVFLTELIEIAKDIQPSTANPTGPLRPYHLRLAKARLDERGVTRSVGGKPAPSISGGGGTGVALRPKKGLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEQ3</accession>
    <name>A0A1Y2AEQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1765-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_74335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000121">
        <property type="protein sequence ID" value="ORY20952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEQ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEQ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AEQ3"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="87797" checksum="71BA6296EA6CB91A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF85</accession>
    <name>A0A1Y2AF85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_554155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000117">
        <property type="protein sequence ID" value="ORY21156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF85"/>
    <dbReference type="STRING" id="71784.A0A1Y2AF85"/>
    <dbReference type="InParanoid" id="A0A1Y2AF85"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1052" mass="112279" checksum="016171406EDF3669" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFH4</accession>
    <name>A0A1Y2AFH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobW/HypB/UreG, nucleotide-binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_554010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000115">
        <property type="protein sequence ID" value="ORY21256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFH4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFH4"/>
    <dbReference type="InParanoid" id="A0A1Y2AFH4"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="376" mass="41591" checksum="2143C5117EC09A9C" modified="2017-08-30" version="1">MSSEPSSSTWTISPEGTERPIPVTCFTGFLGAGKTTTILGLLQQLPKDYKVVLLKNEYGDVEVDSLLAQQSNITGVSEILNGCLCCTMVGLVGNAMEEIKDKYHPDRIIIESSGSAFPATLALQIRELEPKGFKLDGVVTVIDCLNFRGYEDSSPSAKLQARYTDLLLLSKHHLLSERDLDILMDHLGTLNEDTPKIRISKDHPVEPDVVFGLDTSLFEKTGEEGRTWEDIAGGSGWHGDEIETKSVWWGGKRPGHGHGHEDGKECGECHGHDEAIQGEVFIPLDREVLERELGKLNFEIYRVKGIVRLEASTDAEPYQTYILNWAFGRFDLTRFPSLDNDDSLTGVSIRLTIMGERGEVTRRAKQFAAALKAQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFX7</accession>
    <name>A0A1Y2AFX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_553361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFX7"/>
    <dbReference type="InParanoid" id="A0A1Y2AFX7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6559" checksum="EE9E9D82399143CB" modified="2017-08-30" version="1">MADGTEFINVNTDVLIVGSGPVGCTYAKVLLEKTDQKVMMLEMGTQQSPVLGENLKNVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG36</accession>
    <name>A0A1Y2AG36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_553546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG36"/>
    <dbReference type="STRING" id="71784.A0A1Y2AG36"/>
    <dbReference type="InParanoid" id="A0A1Y2AG36"/>
    <dbReference type="OrthoDB" id="74813at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="55376" checksum="168466D92E096F8A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG55</accession>
    <name>A0A1Y2AG55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_553437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG55"/>
    <dbReference type="STRING" id="71784.A0A1Y2AG55"/>
    <dbReference type="InParanoid" id="A0A1Y2AG55"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF11">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="52"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="432" mass="47021" checksum="D67586A62A6C0EEE" modified="2017-08-30" version="1">MDEEVSELSYGSPEAVGLLSGPFETLHKVSLDYLTPRNYGDATFNAVHPLYPGAVVLVGHRKTIVSHFAVGQSLLYADVHGVLLPEDKQRGMQLDTVFDIASLTKLFTTILILDQVGKGKVDLNTSVATYLPDFAVDAKCAITVLQLLTHTSGLPALPHPPLTPGYASVRERRKAVLAALPETPAGTKWLYSDINFMTLGFLLEVVSGQPLDALLEKTVTGARTKMLLLIQSLTAPQPLGMVDTFFNRGNGPKTGYLERTIATEFQRSILGPVGEIFEPLRPQPVQLSVHDENCWALDGVSGHAGLFSTAIDLAALCQMILGRGTLNGKCILEPWTVDLIFNQYSPLDDGYQGLGFRLDVDAWSGPMKSLNTATHTGYVGTTVNIDRESDTFWLHLTNRVHPSRTWSNTNIARQETGRLIAQALGQKTKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGA2</accession>
    <name>A0A1Y2AGA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_553982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000115">
        <property type="protein sequence ID" value="ORY21247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGA2"/>
    <dbReference type="FunCoup" id="A0A1Y2AGA2">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AGA2"/>
    <dbReference type="InParanoid" id="A0A1Y2AGA2"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="52"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY21247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="365" mass="40807" checksum="CD82DFF726CBDFF3" modified="2017-08-30" version="1">MDAGTARKTFELHNDVKFVDPTDELYRYTRKEEREFDLSAPWKVDYEYFHTVKISAVALIKMVTHARSGGIYEIMGVMYGKVRDHTFWITDAAALPVQGTETRVNAGNEASEYMVSFQTANGEAGKNELLRGWYHSHPGYGCWLSGIDVNTQLNNQKFNDPYLAVVIDPNRTVSAGKVEIGAFRTYPEGYTPPSSTASQYQSIPMDKIEDFGVHANAYYPLKVEIYKTKLDEQLLDLLWNKYWVATLSQSLIVSNRPYATSQMNDLATKLNSARGSLSSNTAHLKARKEDPLVDRFSSSRREQGLVVGVDDEETPLSKAAKDSGRIASQVQNGIISQIIKDRLFNTPLDSSLDPALARAAVEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGQ5</accession>
    <name>A0A1Y2AGQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_52162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000106">
        <property type="protein sequence ID" value="ORY21686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGQ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGQ5"/>
    <dbReference type="InParanoid" id="A0A1Y2AGQ5"/>
    <dbReference type="OrthoDB" id="2569251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="238" mass="26532" checksum="F91F8784E35A69A1" modified="2017-08-30" version="1">MPPRAIYELTVDSWASRERIIVRSSAQTIIGFFSLPFIRSGGDNTWGYVLNAIKELVDISGGQGWRLVNEHGELLEDDLAPWEGECWLRAPGGAMSESSPPFSQGPEYFRRGQAPNPEGSFSTRSDSKRSSVNQSRFRTGVIARDGTCLVTDVDYDNCTACHIVPYSRLDVYENILGIQNEVPIFYASCGLLLRDDLHHAFDRLECSFYLKRSLLLVFAVSRDTDRIPACLDGIIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ38</accession>
    <name>A0A1Y2AJ38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_601052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ38"/>
    <dbReference type="FunCoup" id="A0A1Y2AJ38">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJ38"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ38"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="72"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY22581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="210" mass="23527" checksum="73A3730177559083" modified="2017-08-30" version="1">MYEDVVRRPWDTQSQKFGAPVRRRAESIRKLPSTNELWSRPPPELAELRTLESEKDHALARAWVEGFELGDVPKGACEVGYSRSSGPGGQHVNKTNSKASLRCDLGPALGVWLPRFVLAPLSKSPYYHPNPPSLLVNSQETRSSMTNLETAQRKLYEAIFNAAKSVIVGETTQETKDRIAANLKAAKARLKVAKQKRSAFKADKNKRNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ90</accession>
    <name>A0A1Y2AJ90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_551174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="MCFC01000090">
        <property type="protein sequence ID" value="ORY22621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ90"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ90"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ90"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="283" mass="31473" checksum="134EE6D9D0982AC3" modified="2017-08-30" version="1">MGVEQNGKTIVLKLASGASAEIYLFGATVTSWIVDGKERMFLSSKSSLDSTKAIRGGIPIVFPIFGPPPSSPPEYAALKQHGFVRTQDWTLDSIIMDRDEGVSVRLTSPPPPSEFNHKFTLSYVVTLTKHQLSTDVHINNTGNEDFIFQVLLHNYLAVPDVKKITITGLDKGIEFFDKAAGGKMGTWQGGELKITQETDRVMWKVPSQEIKVDDGEGSGFLVKFRGFEDCTIWNPQEKSGKNMADMEENGWDRYICIEPGYVREFKSIKAGEEFLGQQVLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJK8</accession>
    <name>A0A1Y2AJK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_550856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJK8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJK8"/>
    <dbReference type="InParanoid" id="A0A1Y2AJK8"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001075">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="57"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="255"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY22759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="697" mass="78367" checksum="168C3692AAD47410" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK09</accession>
    <name>A0A1Y2AK09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_368462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000086">
        <property type="protein sequence ID" value="ORY22899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK09"/>
    <dbReference type="InParanoid" id="A0A1Y2AK09"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="195" mass="21382" checksum="F77DE97B0446DC14" modified="2017-08-30" version="1">MPHISPYAVFPAPTIGQLDSHRAQRRLRLAEVRAAQEKIVVDVSVPSLSSMFDFGPPRQRFTQRVLHALAREKQHASADVLINISHSVMDSLVSSFCTSGAYALHSNALVFGPDGSVEITLDPVQRARTKKQLKLQVTDETCSSGYLGRKSPSRTQPPSSCRFEGLMGHGARLSSCPKLESLRSVSLTGNERKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKE9</accession>
    <name>A0A1Y2AKE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_550015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKE9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKE9"/>
    <dbReference type="InParanoid" id="A0A1Y2AKE9"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="377" mass="42596" checksum="177C1B0F31C09266" modified="2017-08-30" version="1">MLSKQPSRFIDRAVFIALAIPAVTSLIWPHVLPWAIRAIVIPAACLLTALTGMMNRRSLGSVAVRQRPVDALTRPDKRKIRRLNEMGVELVVEDNPRLFANLSTMQIFSLVLAGFSLIDHTWRSLLFPREEAIYARTVSASEHSITIGLRMPSPDMADTLSVQLCYRPQATSDLAGWELTEPLTLSKDNDWRGLTTFGGLASGTVYDYRLQSATQLYPPDTFLNFTTFADPGMARESHFRFIFSSAAIPSPQPYRPLDWLPRNFFRPTAPQSAPASGVRAASMEQPAWRQLGQWLDDMAERIAWAPIKFAILGDTELVRSSGSLGLKSRRELERSRQFLDAQDVRNVYERLRESSRWGYSQQQYFPLGPNHLVWGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKM1</accession>
    <name>A0A1Y2AKM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_365497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKM1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKM1"/>
    <dbReference type="InParanoid" id="A0A1Y2AKM1"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="70379" checksum="39A8CEDDD3C6A7E2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL32</accession>
    <name>A0A1Y2AL32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_507873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AL32"/>
    <dbReference type="InParanoid" id="A0A1Y2AL32"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="483"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1344" mass="146819" checksum="83777523F7286CF3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALB0</accession>
    <name>A0A1Y2ALB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-alcohol phosphatidyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_549426</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALB0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALB0"/>
    <dbReference type="InParanoid" id="A0A1Y2ALB0"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY23358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="291" mass="32523" checksum="71D6AC8A4C1B3769" modified="2017-08-30" version="1">MLLLSTQMRWDRAMSGIPMIARRLALGPLPQPCVMRNRQFQRSLAFWSRRYLQRSPNRSPRLVHRHVRSSRRSLATLPEPREEDEESSEPTNELHESPYTIPNLLTIGRICACPFLAYTIIHGQLEWATGILAVSGFTDWLDGYLARQWGSKSVLGSILDPAADKALMTTLVGSLTWAGMLPLPLAILIFGRDVALSLWAFSIRYKSLPPPRTLSRYFDPTIPSAEVQPTQISKINTLLQLVLMGVTTVSPLLSFSIAAPLQALQWAVAGTTIWSGLSYVGRGGFKILRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM19</accession>
    <name>A0A1Y2AM19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM19"/>
    <dbReference type="InParanoid" id="A0A1Y2AM19"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13112" checksum="293DCA69FA036DD0" modified="2017-08-30" version="1">MPPTSTNKQIKPSPRKSPYNHNQKHDNDNDDENDDVKPSSSPDSTTSPSKKPKSKVSRPWTAGDLLIIFDVVTKRGASIPNFEGMIEGRTGTQCYSNWKNTIAPSIQKMLVERGNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM42</accession>
    <name>A0A1Y2AM42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Proline iminopeptidase</fullName>
            <shortName evidence="8">PIP</shortName>
            <ecNumber evidence="8 10">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_347978</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="8 10"/>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM42"/>
    <dbReference type="STRING" id="71784.A0A1Y2AM42"/>
    <dbReference type="InParanoid" id="A0A1Y2AM42"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="33"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY23554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="317" mass="35914" checksum="B726F15DE9FD7412" modified="2017-08-30" version="1">MVYPAQEPYDEGFLKVSDIHKIYYMQCGNPDGKPVLYLHGGPGGSVGVKNTVYFNPDIYRIVLFDQRGSGKSEPTAEIKDNTTWDLVDDIEKIRTKLGIENWVVFGGSWGSTLALAYAETYPERATALILRGLFLVSQAELRWFYQEGGTSMVWPAEWEAYAALIPPEKRSDMISAYYELLTDPDDKVSLPAAQEWSRYESSVIKLRQDAEEIARSDNDLKWAREFARIECHYFINKAWMPDRHLVSEEQLAKIRHLPCKMINGRYDSICLPKYAYDLKRTYGDNCELIIVPDAGHSAAEPGTTAALVKAADEFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANL3</accession>
    <name>A0A1Y2ANL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin Pom152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_548028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANL3"/>
    <dbReference type="FunCoup" id="A0A1Y2ANL3">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANL3"/>
    <dbReference type="InParanoid" id="A0A1Y2ANL3"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="4">
        <location>
            <begin position="40"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="6">
        <location>
            <begin position="183"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="483"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="570"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="776"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="7">
        <location>
            <begin position="1077"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="1191"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1278" mass="142224" checksum="E041B236575FB5D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ14</accession>
    <name>A0A1Y2AQ14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_547381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ14"/>
    <dbReference type="FunCoup" id="A0A1Y2AQ14">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQ14"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ14"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="367" mass="40551" checksum="4F0420367DCD8B41" modified="2017-08-30" version="1">MTMSTGRIVTLEQFIIDTFTQIDENGVETPSDIPDQIGGGGTYMIIGSRMFLPPERLGMIVHHGSEPLPKPMQDKLDSYGPEIWVSQKSKHTCLGLNRYRGDHRSFQYLTEPVLLTPKHIFNTPLENPLPTTLHVISYPPRIEQVLAEIHEIKSWSPRIVWEPDAEPLEVVQRVSGSIDIISPNHTELFHFLDLPTTSSSDNLRESVESALKLFLAGLAQPPKTAVIVRASYLGVCYVTTPHISIPVSSPSTPATSSSSVAPLLASGHDIRWVPAYWQVGMEGYKDKVVDPTGCGNAFMGGLAAAFEKNENIDVETAIIWGTVSASYTIEQLGPPVLEVCQDGTELWNGEDPMNRVESLRRRLVEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQD9</accession>
    <name>A0A1Y2AQD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_316264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQD9"/>
    <dbReference type="FunCoup" id="A0A1Y2AQD9">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQD9"/>
    <dbReference type="InParanoid" id="A0A1Y2AQD9"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16192" checksum="0E1FA82C82A1D997" modified="2017-08-30" version="1">MCTSCRETHPKTVSLNQKEEYEISGSRGSAHFVWRCSNCKKEHSASFIPIPPSKDTSPRPYTSQNGTFQPLIALDCRGLEFTQFHFTGKWHCLAADDDGNAKGAEFQFDLDEVDEDGRWDDYDEDAAREVGVRELKSRIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQV9</accession>
    <name>A0A1Y2AQV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_545596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQV9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQV9"/>
    <dbReference type="InParanoid" id="A0A1Y2AQV9"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="139" mass="15169" checksum="FA35CB2FA223AB9E" modified="2017-08-30" version="1">MVSPLDQPETPASTSSPAPRSQVDDNPSQSQPLAIEAPSAVIPEQKQEQQEEVHSLDVGDGTVVKLDKLGPMIVNSDGTLSRIQNWQELHPIEQERTVRLLVKKRNLVRLQKLEAEDKGVDGQDKLSALKEAEAGGTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR64</accession>
    <name>A0A1Y2AR64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_561237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR64"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR64"/>
    <dbReference type="InParanoid" id="A0A1Y2AR64"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011832844" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="543" mass="58384" checksum="833590FE151D504B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARA7</accession>
    <name>A0A1Y2ARA7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_308694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARA7"/>
    <dbReference type="InParanoid" id="A0A1Y2ARA7"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="127" mass="14300" checksum="8EC93F6F14C46921" modified="2017-08-30" version="1">MEQCYNGLAAQSWVYNGDNSISLQSASQCVDLTSEFIDFAGNLLLNEPDGSKSDGNILQTWEVSPMPRPLSRKFLIFDSVVQVTLIKNGLHNRRTRRTILDGIYKTTRIAYTTISGRNGHFFVQIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASK2</accession>
    <name>A0A1Y2ASK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF917-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_544005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASK2"/>
    <dbReference type="InParanoid" id="A0A1Y2ASK2"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="204"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="4">
        <location>
            <begin position="603"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="5">
        <location>
            <begin position="765"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="993" mass="105765" checksum="8D836F4D3840657E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATC8</accession>
    <name>A0A1Y2ATC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD-P-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_498839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATC8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATC8"/>
    <dbReference type="InParanoid" id="A0A1Y2ATC8"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="595" mass="68138" checksum="D67FD68C68CF8CE8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATI3</accession>
    <name>A0A1Y2ATI3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic membrane protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_544650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATI3"/>
    <dbReference type="FunCoup" id="A0A1Y2ATI3">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATI3"/>
    <dbReference type="InParanoid" id="A0A1Y2ATI3"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="732"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="778"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="884" mass="98374" checksum="2529990D955E32DA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATT7</accession>
    <name>A0A1Y2ATT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_528575</name>
        <name evidence="15" type="ORF">BCR39DRAFT_542791</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATT7"/>
    <dbReference type="FunCoup" id="A0A1Y2ATT7">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATT7"/>
    <dbReference type="InParanoid" id="A0A1Y2ATT7"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY25962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY30528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="203" mass="23182" checksum="F6DFAD1515C76B29" modified="2017-08-30" version="1">MTLYYTLCFGLLMSEIALFTTIIAPMPFSLRKKMFHFLSENPVVAKVQYALKITFIFVAVLFVDALQRMVRIAQEGAAAKAKQDMADVRTETNYAARRFYAQRNLYLTGSTLFLSLILSRVFYIILDFIQVQESYSALQHKTAKQSGANGEAEELRKRVQELEAKERDFETLKKQAGQQNVEYNRLADEHNKASGNVSDKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU88</accession>
    <name>A0A1Y2AU88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 11">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_543024</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 11"/>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU88"/>
    <dbReference type="FunCoup" id="A0A1Y2AU88">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AU88"/>
    <dbReference type="InParanoid" id="A0A1Y2AU88"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000072">
        <property type="entry name" value="Histone acetyltransferase type B catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="222"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="13">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="13">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="275"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="14">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY25850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="433" mass="50094" checksum="77EDBFFC6149FE98" modified="2017-08-30" version="1">MSQGMEEWLVDSNEAVTIQLVRTSSDSEDLHDEEVRAIEPFHPAFTYPIFGELEKIFGYKGLEVKLSFASGSLKTLLEIEYDSRLDPTSHTPPDDIEAALYKFIPPDYTKSKDTFRDTVTEDAENFKPFGEKLGSYVRKRLSGAKEKGKGKGKGKGKGNGGTTNGKDERIDEELSEDSEDAVVFETYRATWETPGFREYHRRMQLFILLYIEGGSYVQEDEDAWEFIILYERRKRPESGLFTYHFVGYTSVYPFWCYPDSIRLRLSQFVVLPPYQGQGHGSQLYSTLFQHMLARAEVAELTVEDPSEAFDELRDRNDLRYLVKAGLMDDPKFLEGVGSGLRGERAKWELQVRKKHKIAQRQFDRLLEMLLLKQLDRSDPAAVKAYRIQVKARLYRFNYVSMFQSTPEERKEGLARTYDSVVEDYDRILEMTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUL1</accession>
    <name>A0A1Y2AUL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rap1-interacting factor 1 N terminal-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_542764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUL1"/>
    <dbReference type="InParanoid" id="A0A1Y2AUL1"/>
    <dbReference type="OrthoDB" id="2591260at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1498"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1594"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1654"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1541"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1660"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1732"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1776"/>
            <end position="1794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1863" mass="202393" checksum="CB7D6685E7AA3A55" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUS0</accession>
    <name>A0A1Y2AUS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_541374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUS0"/>
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    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="252"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="276"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="333" mass="36017" checksum="8CFB84690FF3603F" modified="2017-08-30" version="1">MSSDRAQLVAMGFEPARIDWALKATSNAGLQPAMDHLLANSDNPIPAADQQAASSSSANEDFDEEDTDALAAHIKSKGGSIKDDDLVAKSIKCSECGKVFRSNATASFHAEKSGHQEFEESTEEIKPLTEEEKKAKLAELRQKLAEKRANQAKEETVANKANEALRRKAGQDIGKAKEDLELKEVQKEAERKKREKLEDAKAKAAIKAQIELDKKERAERVAREKAARDGQAAPPAAASTPLAKPSAAVKSSENPETRLQVRLSTGGPPLTKTFPSDGTLMDVAEWIASESLAYNVDTVTFASTFPRKTFSRDEMTKTLKANGLTPSAVLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVN0</accession>
    <name>A0A1Y2AVN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEX14-like helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_253813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVN0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVN0"/>
    <dbReference type="InParanoid" id="A0A1Y2AVN0"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="232" mass="25415" checksum="FA95DCBD5C8E5311" modified="2017-08-30" version="1">MHPYPSASSSSSSPSSSHRHQAIFDEFESYPFSDDPDFTAGLPTVISAIRGTKRSAAQIDEMIGRAQWFYFTRLRGLQIPWEVYAQHTLRAPLPPSPAGGSTPLQPVPTNPLAAINQISESRRMMMSDDSQGEAAEGSGSGGMSFAMLSRLISEGRAGEVPVQYIPEGINVSLARCLLSSLFSVLCIVFSLLLSPVYFLLLSYLFVLLLIFYLFSCLLFSFLLQSSLASRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVW3</accession>
    <name>A0A1Y2AVW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer membrane protein TOM13-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_252725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVW3"/>
    <dbReference type="InParanoid" id="A0A1Y2AVW3"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="43619" checksum="F42B89AA00B2996B" modified="2017-08-30" version="1">MSDTRDEAEQEMVSAGIASGMEDELGSSLPSSFSLPKSEKKHTKPAAETRAEESENPETSAESSEPVPGMDEWKDTYESYLSTWQAESTEARAKAEATRKRIEDEQAAALKSEADKIKAEKTAAEEKKRQEENRKKLEAELASEGARKKKGTSASEDREKKVKEAWELVRGGGQAKEGEEVVTDARGTMPQDVASGHANAPGQTREPTAYDPTTSTEPLPPSMQESTPASPLPVPTESATLSRHSATTSAWANVSGSGGPFSSGEDSPRESGSGMSSGEMIDIPPASTSQAGQATTDATPHGISSGPDNSSAGPSGGQNNDGPPTQPPSLTLSVFTMPSHLTFSRVVAVLGINLVLPFINGVMLGFGEIFAREVVRVGQIWYRDSGIFGWRRSPRGSTGGRGTTGVGLSGNGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWG1</accession>
    <name>A0A1Y2AWG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Immunoreactive mannoprotein MP88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_470265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWG1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWG1"/>
    <dbReference type="InParanoid" id="A0A1Y2AWG1"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="35821" checksum="7B1D37E7E66B4F2D" modified="2017-08-30" version="1">MGSTNPPAATLGTAINQTSYARLLSLNSIDDFCLFGPPDPNSVIGNSEAYEVAWCTKARNNARVIPDDTFTAVHFVQTPLYWQIQGFGDFTKINIASGDEGGELDPHGATGDGNPVGGNVTTNATGSDVSYQEWMNYMSYNQFCLRICIAENSTYSAAVMCQHTLDEMGCEWVMPGDYTDNSFTSCEADAAYPPGIYPESDGSTSTFAQRYTGTYTAGTSVGTFTVGQTVTPQTPASTPASSMCTTYSTIGGAGIVASSNATSSAASSGSASASSTAASASTTASSSAASSAAASGGSVAAAGSAAGSAAGSSKSSASAAATSSGAAFAQFSGPNYGPLMAGVLSLVALIAGAGVIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWH7</accession>
    <name>A0A1Y2AWH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_539395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWH7"/>
    <dbReference type="FunCoup" id="A0A1Y2AWH7">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWH7"/>
    <dbReference type="InParanoid" id="A0A1Y2AWH7"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="86" mass="9359" checksum="15379EF424421BA5" modified="2017-08-30" version="1">MGGKMLRYKVKARKDPLFIPCVAELTALLGCFSASSDLRVTEHCAEAAKSLHTCMGKTRIPSKGYGGKKSDSSINYLLNKVSPKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWN9</accession>
    <name>A0A1Y2AWN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase B complex non catalytic subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_541363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWN9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWN9"/>
    <dbReference type="InParanoid" id="A0A1Y2AWN9"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="833" mass="93479" checksum="764FFD4003471D3E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX65</accession>
    <name>A0A1Y2AX65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_539973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX65"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX65"/>
    <dbReference type="InParanoid" id="A0A1Y2AX65"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF93">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="441" mass="48801" checksum="FBA4EFF7907DCFBD" modified="2017-08-30" version="1">MPVADLSTLPPQERAEKSLLFKPFQLGGMGRLEHRIALAPLTRNRGRPSDKHEGTWVPWDIQTKYYTQRATKGGLLISEALPISLQARAGSMFNVPGIFTDEQKEGWKSVVEAVKPTGAVFVAQLFHGGRSGGHTALSRAVSSSATRIESSLMGGPGDVPDEMTLEDIKRTIGDYVQCAKNAIEAGFDGIEIHGGNGYLPDQFLHSNVNKRTDAYGGSIGNRNRFVIELCEAVASAIGPDKFGLRLAPYGFFNETRGTQRTEQWSELCRALAPKGYAYIHFMEARYDEVLSEQTKLSALGQEMSTDFSSDGLPTLEPFRAILGKDTPMIVAGGYDTENCWEVVDSGRADIIAFGRFFTSNPDLVWRIQNGKELVKYIRPLFYVWPEGKPAQGYVDFANHEENVHTQEEKLVLEEHKKRGIVVAKPGWQLSQDGVQLGEIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX70</accession>
    <name>A0A1Y2AX70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative alpha-1,2-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_565773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX70"/>
    <dbReference type="FunCoup" id="A0A1Y2AX70">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AX70"/>
    <dbReference type="InParanoid" id="A0A1Y2AX70"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="394" mass="46465" checksum="60CF4E6024C85DDE" modified="2017-08-30" version="1">MMIPKWRYVGIAAGVLLAMHALLSIHPTYRATTSPFSLLPSGSNADSWEPNEPPDSAIPTLSGQKRPTLEELNSDALEGRRKANAVFVVLARNSDLWPFLDSMRQMEDRFNHWAQYDYVFLNEEDFSDEFKRYTSSMTTANCYYGKIEHDHWYQPDWIDEDKATKAREEMIRKKVIYGHSVPYRNMCRFNSGFFFRHPLLADYDYYWRIEPSVKYFCDLTAYDPFLVMQDEQKVYGFTLSLYEYIETIPTLWDTVKEFIELHPEYVSEDNAMAFLSGDGGDTYNKCHFWSNFEIGDLNFWRSDAYMAFFEHLDAAGGFYYERWGDAPVHSIGAALFARKDQIHFFDDIGYRHEPFQHCPQGEAHTRGKCWCDQSNNFDFEWYSCTKQYVEMFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXA4</accession>
    <name>A0A1Y2AXA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_539006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXA4"/>
    <dbReference type="InParanoid" id="A0A1Y2AXA4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="259" mass="27483" checksum="7C89D771C8F0487A" modified="2017-08-30" version="1">MYLNNYVVIVITFITLSLSQLVTSITITTTTLAPIPPLGLGQARNVKEENRLIPRQNISMYNITKTTTNGNNQTVFEADVPVVCFAGCQVPLTGYYTCNLKLDITQCLYTCNTPNFTLLSECFDCLIANGAPKENSTRVQAELQGVVEFCKQNGVTLTGTAPITAVPTTTGPFTTTESGTAITLPWYNGSMTNTLTLGGTEIALSPSSIPQATSTTSASASSSSAPATSAAEPLLKSGMRYVGLCFFVGMSALSVFDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXE0</accession>
    <name>A0A1Y2AXE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_497647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXE0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXE0"/>
    <dbReference type="InParanoid" id="A0A1Y2AXE0"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="200" mass="22429" checksum="4FF3055ABC89A995" modified="2017-08-30" version="1">MIRPEIGEDGGWSFFNGHLKGYFISTGEHKYSYRQVYKANSPYSGAGRNSILTPALHYHLYQPETYTVNGGRMLYEIEGRRGVLEKGETFTFPPNTPHTFWSDESTGEDMDITTSIEGGPNVGFDEGFDHNFFGYWSSQVAQGKPLSPFQMLLFLYTADVVDASIPLGLGRAANFVLGLLVGKYLLGYEERYKAFDTKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXH2</accession>
    <name>A0A1Y2AXH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60s ribosomal protein l7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_540701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXH2"/>
    <dbReference type="FunCoup" id="A0A1Y2AXH2">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXH2"/>
    <dbReference type="InParanoid" id="A0A1Y2AXH2"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.15.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="250" mass="28453" checksum="8597B58B7610A9AA" modified="2017-08-30" version="1">MAPSTSVPTAEQVAVPETLLKKRRTNEATREAKLAAAAEARKHRQAQRKVIFKRADEYVKEYVAAEKEEVRLKREARKTGDFYVSAQPKVFFVVRIKGISKIAPKPKKILQLLRLLQINNGVFVRVTKATQQMLHLVQPYITYGEVNLKAIRELVYKRGYAKVNGQRIPITDNQIIEKQLGKYGIICIEDLVHEIATCGPNFKQATSGLWPFKLSNPTGGWRPRKFLTFIEGGDTGDREKHMSKLVHQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXZ7</accession>
    <name>A0A1Y2AXZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_538109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXZ7"/>
    <dbReference type="FunCoup" id="A0A1Y2AXZ7">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXZ7"/>
    <dbReference type="InParanoid" id="A0A1Y2AXZ7"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="646"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY27459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="714" mass="80512" checksum="BFD4FB8EF8564B85" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYV8</accession>
    <name>A0A1Y2AYV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_218696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYV8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYV8"/>
    <dbReference type="InParanoid" id="A0A1Y2AYV8"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="184"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="578" mass="65393" checksum="77A71FABD8B99E44" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ82</accession>
    <name>A0A1Y2AZ82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-glucan synthesis-associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_536576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ82"/>
    <dbReference type="FunCoup" id="A0A1Y2AZ82">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ82"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ82"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="252"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY27881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="684" mass="75006" checksum="9F2813F7BDBDA7FB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ98</accession>
    <name>A0A1Y2AZ98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyl CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_469639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ98"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ98"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ98"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="443" mass="48062" checksum="B29E138457569FC3" modified="2017-08-30" version="1">MLRWSPQLSASTSRRCIVCYRAYSAVPADDRPLAGIKVLDLTRVLAGPLATMMLSDLGADVIKVESPKGGDDTRSWLPPSAPLPASKAGEADYPRPDLPPESAYFLQANRNKRSLTLNLKSQAGQEVARRLVEQCDILVENYVPGKLDQFGLGYDQVRKINPKLVYCSITAGYGSSGPYAKFPGYDVVIEAEAGLMHITGEKGGTPVKVGVAATDILTGHYAQSGILAALLKRARTGRGSRVECSLFESQIASLVNIGANYLISGQEATRMGTSHPSIVPYQVFPTQDSFIMLAAGNDSQFAILCSPAIFDRTEWINDPKFATNQMRVQSRDEMIKLIEGVLSEKTTEEWCERLSGKGLPFAPINNIAQTFAHPQALARKVVEEVEHPRAGIIKLAASAVTYDGQKPKAYRPPPYLGEHTTEVLSELGYGDDEISSMQKGGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZG7</accession>
    <name>A0A1Y2AZG7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_536601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZG7"/>
    <dbReference type="FunCoup" id="A0A1Y2AZG7">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZG7"/>
    <dbReference type="InParanoid" id="A0A1Y2AZG7"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="111"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="477" mass="53287" checksum="D63B8F218646D139" modified="2017-08-30" version="1">MPSITPATVQIDYTKYFSKESHGRIRSQLKELRPYHSVPDMISLGGGLPHPSTWPVNGMTLSVPFAGKSVFVPGYNGRSEDALLPLEPYTAPLKTDSLSPDLAEELQYGSTYGPRHLVNWCKEHIQRIHSPRYADWEVLSTAGNTDGMDGILRSLFDKGEYLLVEEFAYPGLLSPATSMGIRCLGVPMDTEGVNPLALDEIMSTWNEVERGGPRPKMIALVPTCSNPCGVTINEQRKIELYAICRKWDLLIAEDDPYCFLQIRPADKFIEPTFLSMDTDGRVIRIDSFSKIVAPGSRMGWITGPRVLVEKIMQSRESSTNCPSGFSVSAITAILRAWGGHEGFEQKYIPHIASIYTERCLAMVSYLKAHVSPKLIDYPTPSGGMFLWVRLKVETHPDVATKTPDEISKELFHKCIEHKVLIVPGHFFKAPQSVVSTREEDAKKVFVRISFSLPPLDRMEEAARRFGKALAEAWGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZM0</accession>
    <name>A0A1Y2AZM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_468694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZM0"/>
    <dbReference type="FunCoup" id="A0A1Y2AZM0">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AZM0"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="540" mass="59924" checksum="C4164135D76B46A0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZZ3</accession>
    <name>A0A1Y2AZZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_535586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZZ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZZ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AZZ3"/>
    <dbReference type="OrthoDB" id="5357513at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="284" mass="32297" checksum="326162BAE434F0FA" modified="2017-08-30" version="1">MCRMVQTVMPNIMYGTAWKKERTTKLVAQAVESGFRGIDTACQPKHYREDLVGEAIANLISAGTVKRQDLFIQTKFTGIDGQDASQPLPYDPRQSITDQVTKSIEKSLQNLRVEYIDSVLLHSPLRTKHQTLEAYRTLEKFVDDGRVRALGVSNCYDPALLEWLINEARIKVGVVQNRWYEGNGWDWDIYDICQENGIRYQSFWTLSGSPTLLRHPVLQSLAKKSQMTPQQTVYKLCQLWNITPLCGSTTPAHVHEALSVERSHALKADDEEVRTLLGLMRGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B063</accession>
    <name>A0A1Y2B063_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_215672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B063"/>
    <dbReference type="STRING" id="71784.A0A1Y2B063"/>
    <dbReference type="InParanoid" id="A0A1Y2B063"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="288" mass="32320" checksum="EE1FDD2B6D3D3A80" modified="2017-08-30" version="1">MNKHSMLDSSSPTALQRVISASHRLHSTFSPSVDDSRPIRLRGKRPQLGSAPRLPHLVSYIPDPEVRARIRHLVEMGIQRAEQTTQRVFRETIAQTVSIETLDGTSDFDVENMLCDCFEGILQRAVDKILDSVMKVVIKHATSFPQEGLRGNSTFSQHVVYILEQAYLHAQVLTQAECAIVAQRAGISHQQVRTWTSFTLLFGRRATHGVPETKSATSDLRFKPTRPCFLFVWFLILSPFFVLLLWQLLMSRSSRTSGIAKGAPSDELLAPLLCRGRSLSRPSLDQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0E3</accession>
    <name>A0A1Y2B0E3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_594225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0E3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0E3"/>
    <dbReference type="InParanoid" id="A0A1Y2B0E3"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF5">
        <property type="entry name" value="4-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="304" mass="33544" checksum="99ED5143F2C72382" modified="2017-08-30" version="1">MHILLTGAAGKVGSHVLKYFLNRGHSVTALDVVPLPVSLTSSVPESQAKLLRSQVIDLTDFKAYQAILESSPEGIDGVVHLGAIPDPLSHDPRIVHNNNVTSSYNVLQTSMAHGITRIVQASSVNAPGLSFGPEGHLRFDSLPIREEHPSRPEDPYALSKAICELQASALCRYTPGLRIASLRFHMCCPDYSTATTGSRWQDLWAWTSFDACASACLLALTSEGWEGHEAFNIVAPEICWEGGVSPESKEFGKLETTAVQLVEYSWKGKYDALDEEWWKDRPRRSLWDSSKAERLLGWDHDNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0G9</accession>
    <name>A0A1Y2B0G9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_535441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0G9"/>
    <dbReference type="FunCoup" id="A0A1Y2B0G9">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0G9"/>
    <dbReference type="InParanoid" id="A0A1Y2B0G9"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="AH" evidence="4">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29505" checksum="42CE24159AC52295" modified="2017-08-30" version="1">MSWGGLKKATNRFGTTLMQKTGHVERTIDREFAEEEGRYRTMEKETNNLQKDAKTYLDAIRAMASSQTRIAETVGLFFTADRTSDGAMAGHAYKSAVDELDAGVGRELDAPYRATVLEPIGKLNSYYTNINAAIDKRNHKMIDYDAARAKVKKLVEKPSDDTSKLPRAQAELEEAKEVFDMLNDQLITELPLLTDQRIPYLGPSFEAMIKIQLRFAQEGYEKLSGVQRYFAENIRDEYANGVLDGQVEGVLDQMKELSIFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0I8</accession>
    <name>A0A1Y2B0I8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BCR39DRAFT_468734</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY27997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0I8"/>
    <dbReference type="FunCoup" id="A0A1Y2B0I8">
        <property type="interactions" value="738"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0I8"/>
    <dbReference type="InParanoid" id="A0A1Y2B0I8"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="28"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="413"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ORY27997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="462" mass="51537" checksum="2506100BA72A77DF" modified="2017-08-30" version="1">MASGGIVDPMLAYRAKRDRERRTVLKAYKILGFISSGTYGRVYKAILLPPPKSSAPALSTTTRAALSIPRTKPIPNTVADDDALNNPELCMRPGDLPAREGDVFAIKKFKPDKEGDVLTYAGISQSGAREIMLNRELHHRNLVALREVILEDKAIYMVFEYAEHDFLQIIHHHSQTVRTPIPQTTLRRLLHQLLMGVHFLHSNFVLHRDLKPANILVTSQGVVKIGDLGLARLWHKPLAAGGLFGGDKVVVTIWYRAPELILGAKHYTAAVDLDLWAIGCIYAELMSLRPIFKGDEAKLDTKKSLPFQRDQMTKICEVLGPIKPEQWPGVVHMPEWKSYQLCGHMPTPHPLPNWYHSRSNSSLGYDLLCRLFEWDPAKRLTAREALSHGWFHEEGGVKAKSVFEGSSITYPTRRVTHEDNGDAKMGSLPPSLAAPRLPSSSNFRPASGPLGGGPNTKRTKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0V7</accession>
    <name>A0A1Y2B0V7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_535950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0V7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0V7"/>
    <dbReference type="InParanoid" id="A0A1Y2B0V7"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="685" mass="76782" checksum="FF432C7EABDA9DB1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Z9</accession>
    <name>A0A1Y2B0Z9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_536996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Z9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0Z9"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Z9"/>
    <dbReference type="OrthoDB" id="3345311at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25568" checksum="1EDF58F7413EBD83" modified="2017-08-30" version="1">MSGAQLPPDAIEAILKYLDLPLSSDLPLAPFEFLSTHLRILPSSLLTPLSKLVPPRQRSFIPLIKSRRLVYASQQPRPPLLRADRGRLRWPLLWERLGGSSLPVPSSEVEEEENWVESEFNFRSVDGEPRQHVRKLGGFLRELEEEREQEGVREARRAERRLDDVGEEFDSDSDDEDERQRDTTRIQSGLAIGADVDQEKVKESFEKRLLEIFVDGLDIMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1I8</accession>
    <name>A0A1Y2B1I8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_534328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1I8"/>
    <dbReference type="InParanoid" id="A0A1Y2B1I8"/>
    <dbReference type="OrthoDB" id="2596052at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="755" mass="83993" checksum="5876E92B2D582E3D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1S6</accession>
    <name>A0A1Y2B1S6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_533773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1S6"/>
    <dbReference type="InParanoid" id="A0A1Y2B1S6"/>
    <dbReference type="OrthoDB" id="2564958at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="178" mass="19302" checksum="869114DF1F100791" modified="2017-08-30" version="1">MSTPTPTATARPVHVSNLTRQDLQGDLTSLLNLPTSVLRPLLPDSSSSSSTSSPSFPSTTYPSSSSQSPIKPSSNTISTFESISAISLLDDFSTSFSPTSTSTSTSTFTSKDETTTKNGKLSEIDNKEKSQQLIKAYIRDMRDLLSMDTRESEILGIRLDQMREKASEVVQALKDVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1U2</accession>
    <name>A0A1Y2B1U2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose-binding domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_468216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1U2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1U2"/>
    <dbReference type="InParanoid" id="A0A1Y2B1U2"/>
    <dbReference type="OrthoDB" id="10052260at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16736" checksum="3CE75611134E642A" modified="2017-08-30" version="1" fragment="single">STSHPASSSIKRSLISSSNDDEAFTASSLPSSVHLIFPTPLEGVTHLALTFQGGFAATTATVYVALRPHGDESGIQLGLMMGGKIYPEDKNKRQVFEIPFPPNSELPPTELSSARADLPKTNLGNGLTIVTEIKVEFEKASDSYGRVTLYSIEVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1V6</accession>
    <name>A0A1Y2B1V6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tho complex subunit 7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_533944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1V6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1V6"/>
    <dbReference type="InParanoid" id="A0A1Y2B1V6"/>
    <dbReference type="OrthoDB" id="2575566at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="40883" checksum="8841D587327D4375" modified="2017-08-30" version="1">MPNAVTPLSEDALNRYRLAHTDRDLKPLLTRLHRLAHILPTASTSTSIPEDVEGGNVRNGNGGVGNGNGGVGVGVGSNGENGAGVGVGEDGGDEREKQILEMEIMKWGVSVKRSWAAAIGIQKEEMRLRERAKATVERTEMLEAMLIEEKKLLERRQRERDGMRKCDEVAERIRGRKRSRQELDEQIETLQQEVAEHRTSYEAYRSAVQSRIDTFAQITRLVDECRNFKLPVDPNAATYPSSDNKMEIDEPLVPSASGPTTSPTTTTTNASNTKLNAAAPTFQPKPSLPANPTSTSRASTPSSPSGISTLPPPPVARPPTSRAPSGSSRGARSLPSKPSGLRSSTLPTATGGGGAGGGGMEEGEVGEDGEVDDRRKSRTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2R4</accession>
    <name>A0A1Y2B2R4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_532642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2R4"/>
    <dbReference type="FunCoup" id="A0A1Y2B2R4">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2R4"/>
    <dbReference type="InParanoid" id="A0A1Y2B2R4"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="149"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="388" mass="43665" checksum="0D537D2F14385444" modified="2017-08-30" version="1">MILCPTCRDFVIAVQLSILCCYSICCFVSFPPSVYLAIQETFNMDIKLPWNKSLPTSEASRRWRIVWSYLPDWCLTIFLWGIFYLLDTIDGYRRLFSVTDTSLAHPFAHHERIPIWLLIVLCGIVPGVLIIIVGGLFRRSLWDVHSGILGLILSLGLSETFTDIIKITVGRPRPDLFDRCQLPSDLTSDPTHGLTSWTACTRTDLLNDGFRSFPSGHSSFSWCGMWFLILYMAAKMRVYNRLGYTYKSWLLLAPLSCASLVAVSRTMDYRHHATDVIAGAIIGILTGWWGYRQYYPPLSHPQSYKPYAPRIPKPAELPLHHRHSMEGTNTPFLSPEQQQQQQTRSPLPGSFDGNGNGSSGAMGNDRGLGGMGNDHGEDAETVPRDNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B328</accession>
    <name>A0A1Y2B328_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_532765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B328"/>
    <dbReference type="FunCoup" id="A0A1Y2B328">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B328"/>
    <dbReference type="InParanoid" id="A0A1Y2B328"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000070">
        <property type="entry name" value="Endoplasmic reticulum protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="124"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="434" mass="47802" checksum="590FF6CF29511F7D" modified="2017-08-30" version="1">MEVNKEEALRCLHIAHRHRTSSNLPSALKFAKKSVSLYSTPEGVAMVTVLEREISTGGGPSTSSSSSSTPETNASTAKASGVEEHVTNAKARPAASHAPKKEKREYTAKQVEVVKRVKGYQHHQYYEILSVERTCTENDVKKAYKKLALALHPDKNGAPGADEAFKMVSKAFQVLSDADLRAAFDSNPNVDPTQRNAGMSRGGGGGGGGMQGFNGGFQGDINPEDLFNMFFGGGGGGFGQANVFTFGGPGGFQAQYARPRRRAAAGTEEQTSPLVALLPLLVLFLFAFISIVPTFFSETPIPEPAFSWSPSETYDLDRHTYARGVEYWVNTNDWNESPLWKTVPEERRARKDAALYSPKVKAFERNVENYYIRHLQNECEDFNALKQQRISSEAGIFGIGADYDKIRAIRAEKSPACEQLKNWGLMRTQTQKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3R5</accession>
    <name>A0A1Y2B3R5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_575008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3R5"/>
    <dbReference type="InParanoid" id="A0A1Y2B3R5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="283" mass="30549" checksum="75E558FBB53BFAEC" modified="2017-08-30" version="1">MSGTLISRVRSLWNRTVRPSWNYLPLRDLSASNRITNSPSSRPDTNPPSDLPSEAQDPSIMTDMEANLWASSEALGSAQATSAPLQESPSSLSGTATRTITPSESEPGSTAGPRSSNPHSVIHIDTDFSLAATLRNRRSSARRPYSRRPPLWCETRTCLIIKAISVGVGILTVWELFRRGVECYDKTCGENCPSFLLKDKGRGCSSNKRGDLFELAVSANYPTTSLPIAITDPLPPSSSTFSPAGTLDGPAFTEMIDDGDEDDHGDNDDEDGGTTLWLTKGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3W0</accession>
    <name>A0A1Y2B3W0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_481597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3W0"/>
    <dbReference type="FunCoup" id="A0A1Y2B3W0">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3W0"/>
    <dbReference type="InParanoid" id="A0A1Y2B3W0"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="206" mass="23614" checksum="3BA7CB91B03D54EE" modified="2017-08-30" version="1">MTIFSLYIFDRHCDCIYYQDWHRTRPIRPPSIPNFRPGVHRLPPPLDPLAAQSTVRESIFDRDHAVSNVITTNGARVLSGSTPATNRGYTGLPFDEETKLVYGVVLSMRNMVKKLSGRDETFTSYRTNTYKLHLYETLTGYRFVLLSDPSTDSLRFVLRQIYVGPFVDYVVRNPMVQLDSRTEGIDNDHFRAAVDAHMRGLSMFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B496</accession>
    <name>A0A1Y2B496_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">BCR39DRAFT_481687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B496"/>
    <dbReference type="STRING" id="71784.A0A1Y2B496"/>
    <dbReference type="InParanoid" id="A0A1Y2B496"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="190" mass="20682" checksum="92171FEBFC46BE37" modified="2017-08-30" version="1">MLATASTSRVLARARWIHTSSALRDEARSALEIKLRDGLKAAMKSKDKPVTTCMKTILADVVNATKSSPDPSKPLSDDGVIATLRKGIQNRTQAALSYAPDSSSSHSENYENLQKEISILQSYLPKAPSLDEISRTLSEIVQSLDKEARENKSVVGIVMKQLMEKLGEGAKGVDKKEVGKLVFDALRGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4N7</accession>
    <name>A0A1Y2B4N7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_168046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4N7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4N7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="88" mass="9864" checksum="E3381664283E26DC" modified="2017-08-30" version="1">MWVLGCTMWRCTTFLHVARRLELAKPCKEEKGRANQEGTHQTSVGRSVMTGSDAVIFGAIVVMCCYFGISRKMTRNRMASVAVVLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5C7</accession>
    <name>A0A1Y2B5C7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase M24, structural domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_531646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5C7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5C7"/>
    <dbReference type="InParanoid" id="A0A1Y2B5C7"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000009">
        <property type="entry name" value="xaa-Pro aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="5">
        <location>
            <begin position="47"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="377"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="6">
        <location>
            <begin position="602"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="674" mass="76170" checksum="69FE4BDDA9F8D73A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5Q3</accession>
    <name>A0A1Y2B5Q3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_574114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5Q3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5Q3"/>
    <dbReference type="InParanoid" id="A0A1Y2B5Q3"/>
    <dbReference type="OrthoDB" id="2582280at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="325" mass="36291" checksum="33D98CAFAA6EA716" modified="2017-08-30" version="1">MRGLRGPSPVRTLGTLSEQDQTMRLPGGRLLGFRPLIYLHGYPSSRIEAKPADDMAGRHGIRLLALDRPGFGLSTPQPNRTLLNYAEDVRHFAEVMHLDRFAIIGVSGGGPFAVACTHALPRRMLTGVGLFASGAPWAAGAHHMSWTRRILCWLSNHWPSALGLVIRASASFVKMIMSSGPGVRRLDAFLDKAGTKEEARRVKNGPLLRKESKEERREYLWKVLAGEPLRQGSDAAVLEARLLSAQDWGFKLEDVDFDPIRIWHGLDDDNSPIAAIRYLANQLPHSELHEFEGDTHYTMFRHLEGALQELLLEEKPKTVEGMDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5X8</accession>
    <name>A0A1Y2B5X8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_169196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5X8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5X8"/>
    <dbReference type="InParanoid" id="A0A1Y2B5X8"/>
    <dbReference type="OrthoDB" id="2592707at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="277" mass="30993" checksum="D231AE24B925D6A1" modified="2017-08-30" version="1">MVVSMTTSSTTPPKAMPTCYIDEIPETPGPIRARVNNLQKQIDELVRKEHALNRKHKSEMSAVESTISLQRTELGQTHLALKASQSEAARYKVELERCQAEGEAMRQELNVHSVVQQHKALLVLAQEQMQIIELEQRLVQAEAARIMRDHKLALFQAKEDDLGAELAEKDAVLAQVEAKLDKANTSLAHERAANSKTSKLSNSAGNQQELSEARAEVTRMEGKVERLEGKVRALKEGEKEAREELEQWARDERGKHGSVSLISLEARIITEYCVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6K5</accession>
    <name>A0A1Y2B6K5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_494762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6K5"/>
    <dbReference type="InParanoid" id="A0A1Y2B6K5"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="536" mass="60383" checksum="BC9EDE031528582B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7C4</accession>
    <name>A0A1Y2B7C4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7C4"/>
    <dbReference type="InParanoid" id="A0A1Y2B7C4"/>
    <dbReference type="OrthoDB" id="3146826at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="82" mass="8748" checksum="BEE505E0468C354E" modified="2017-08-30" version="1">MSSDEAFVSKLEADAPETNLDTAKEDRIAADSEATEEVEGLKDSLGGGQVLDDSEGYTRSSNKDSKPLQQEQDVDAAIDALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7W0</accession>
    <name>A0A1Y2B7W0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_105118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7W0"/>
    <dbReference type="InParanoid" id="A0A1Y2B7W0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35226" checksum="2ABE420083662C87" modified="2017-08-30" version="1">MAAHLAQPSSSDAFRLPAEVSPEEFEPPAMQSDSSTPWDSAWLLDFHDLSSLPSLTGGPSDPSQVSSSSQVSSQWQRQMDQTGRFGATSGLSVTADSSDSLESMDGWYDVGATASGTTVVTPDSTSVWTSTTSTMTSMTVDPSHLGIHIPNGDPFSDMPTIVEGTEIFSAEAIPPAHRDNDLSSSYQTPWDDFMCSLPFNNRPPSISSTVNLTNPATVTLLPSPIPPSLRPKAHLSHSRSFDQDPPVLIANDIGPPSPPMVQRRRHVPLGHLPESAIPIVRGSPTSASTSRCSRCGTTLSSKFAPIDSMRVVCNVCRLFMLTHRNSHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8Y8</accession>
    <name>A0A1Y2B8Y8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_558547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8Y8"/>
    <dbReference type="InParanoid" id="A0A1Y2B8Y8"/>
    <dbReference type="OrthoDB" id="2558413at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY30555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="85" mass="8464" checksum="53C30407D16D0D9D" modified="2017-08-30" version="1">MTGCSGDPSNCGFCGSTHADCAKTEVSGCSANPGDCAVCKGVGCVAMECTGDVKTCKACKGNFQSCRKAEVTATEGIERSRAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9U4</accession>
    <name>A0A1Y2B9U4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_525949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9U4"/>
    <dbReference type="InParanoid" id="A0A1Y2B9U4"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="866"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="97847" checksum="255D2AC49E30C733" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAC0</accession>
    <name>A0A1Y2BAC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_80560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAC0"/>
    <dbReference type="FunCoup" id="A0A1Y2BAC0">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAC0"/>
    <dbReference type="InParanoid" id="A0A1Y2BAC0"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="3"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="343" mass="36788" checksum="08ECA9FF3D009424" modified="2017-08-30" version="1">MRSSTVLLLSLRSLAHETIKNLVLAGIGRLIIMDDGLVMEADLGGGFLFREEDGAVGKERTAAAAPQIQSLNPLVSLSAIPTLAPFVRDPGSSGAAIDEEEQMVEFLKREKVDVVIACDMLTTQTEVIDKATRKAGVMFYAAGTYGFYGYVFADLGEEYQYLLTSPKSDTNPNPAPGKMVLRFPSLSTLSDRSNWGSPSTQTSAGGSPFRGLSRNQTKDRDPATALGILSVWEYQKRHGVLPEGAPGQREEFSEIADELRNALGINQKALPEIEPTILDHLSSHATHFFPPTLAVVGGLLAQDVLRAISKKDTPTVNLLCVDSMGGIGAVSRWAMDGPKPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAM3</accession>
    <name>A0A1Y2BAM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_587368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAM3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAM3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAM3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="272" mass="28551" checksum="CAC94748FD6D6EA8" modified="2017-08-30" version="1">MYLTDIRRQTLPSTSTSTPTPTTTQSDHSGQQPLMNNHSPSFTPSQTPPLHRPELSTSTSFSSGPSNHTHSSTPPPNVSISFSPDLPSPIRSGTVPPNRHKTNISWAPESYTSPTNSSRHTPEKTSYPRSSPTFGVGGASPSIGRSRAMPFSGNTTPIGTSQPAPWKFPTTTSNPASSPQITRPATAAYPPLSAASPPQMIRPATATQTRPSTTPPPLISRPATAASNTFPTRSTYTPSPRGPSRSKSVSSGPETGGGGDYFGPAPWNAPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBH8</accession>
    <name>A0A1Y2BBH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin cortical patch SUR7/pH-response regulator pali</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_493143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBH8"/>
    <dbReference type="InParanoid" id="A0A1Y2BBH8"/>
    <dbReference type="OrthoDB" id="2589196at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21964" checksum="81395038589DFCAA" modified="2017-08-30" version="1">MFRYYDCLEAHILIGLISSSSATILLFLTSFSAPYINSIYFLLTPSPDNLRLGGFGYCSLKSCTTSMIGYDVGPEMIQWLTRTHILFPLAAIFMSIALIFLILSLLKTGRFMWNPIYFRTTALFGSIIAIIAEIFALVNWVQARHKYDDHQGQRARYGSALWLGLVGAITAFLSVCIGGPAFEGSVMYRHTGTAYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC10</accession>
    <name>A0A1Y2BC10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_525975</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC10"/>
    <dbReference type="STRING" id="71784.A0A1Y2BC10"/>
    <dbReference type="InParanoid" id="A0A1Y2BC10"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="247"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY31625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="454" mass="50067" checksum="A61F94C1F9147840" modified="2017-08-30" version="1">MGREIINVSVGQAGNQIGTAFWENILQEHGLDKSGKYVGSDQQQLDKVDVYFTQASNSKYVPRSVQVDLEPGVVDLVRSGPLANLFRPDTFVHGESGAGNNWAKGYYTEGAELIDPIMDILRTQAEGADSLQGFQVLHSLGGGTGSGLGALLLGKIREEFPDRMLATFSIFPSPKVSETVVEPYNAVLSTNTLVENSDITCCIDNEALYQICVSELKNKTPEYKDLNGLIAKVMSGFTTTLRFPGVLNSDLRKLAVNMVPFPRLHFFTAGYAPLVASASRQYTASNVHDLTTAIFQKKSLLAAIDPVMGKYLTVSVAYRGKLSMRDIENAVWDFHNKNSAYFVPWIPNSSLTTLCTIPPQGQPAAATLVANTTAISEVFKRSHGQFRQLFKRRAFVHWYTGEGMDEMEFTEAESNLSDLCNEYDQYANADIDDEYEEGEAVEEGEAQEFYEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC59</accession>
    <name>A0A1Y2BC59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC59"/>
    <dbReference type="InParanoid" id="A0A1Y2BC59"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="144"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="628" mass="69810" checksum="94E2D71C9C26DE28" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCP5</accession>
    <name>A0A1Y2BCP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_523869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y2BCP5"/>
    <dbReference type="Proteomes" id="UP000193986">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="277"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="395" mass="41389" checksum="57235A56D761D46A" modified="2017-08-30" version="1" fragment="single">MSAYSPGLVSTTSAATSSLPIRGSLRRGGIHRPSLDRPPPAALLPRMTTAVTRNMPSSRGRGTESTLARMPISIIPTSTNLSRTAVVQSITAPTTFVSSPRAFHTGGSSTSSIILAQQSRPPASSSLSQASSSPSLALSLHSAAPYNSPPPSPAPIQARYSLLASSSGSPVSTLRFRPFSSDSLGSTLGSRASSSDSLVSTLSTLRFRPLSSDSTATLQRPPSISSIVRPSNSSSTSTLRRPPSPGMSSIATPSGTPPSSSTPPSSSVVDPGPREEDQQLAEGLELWRLAAMTYLGGTSESQDTTQLDGTPQPEDNTTYLDSTSHSQENADNSAASADPSTSANATTSSTLDLRVRPYWRGPGEYAFGERRETRVARRERATGVIHIKIEIQTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDH3</accession>
    <name>A0A1Y2BDH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_378994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDH3"/>
    <dbReference type="InParanoid" id="A0A1Y2BDH3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13692" checksum="DF8C6807E57BE351" modified="2017-08-30" version="1">MQVGSSPKFSRSRLLSDSDIGESLETSTAAEIRSRRPRSHSWTSPVIVARRKSHALLGYSREDGLRELEMLEEEHGGSLNRPDKRRLQNRIAQRAFRARSKVHHADVSDPFFSLHAYPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDZ4</accession>
    <name>A0A1Y2BDZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_520955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDZ4"/>
    <dbReference type="InParanoid" id="A0A1Y2BDZ4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="36"/>
            <end position="51"/>
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    </feature>
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            <begin position="85"/>
            <end position="102"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="244" mass="24861" checksum="7EFBAC0F11CFBD41" modified="2017-08-30" version="1">MSNFSNTQPPSQRQPHSRTTVPLHSNRNTGHPPRTNTNPSSSWAMSSSNPNYIHGSSPGSAISPGMSHSHRTYGHSSNAGQQGHVPPSSFGGSPGPVFSQGGRRQATDPVSPSTPGSSNGYGADISASNGSPLNPSHGRPARQSSSIPVTPSTGPTRISGGFGSSPDSVTTPSAFAHHGSKNSHLPDQELASLNLGGSGNGGTNGHSGGSQPSTTHPNTFMVGSPNQNQLYRPSASDGSQKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE31</accession>
    <name>A0A1Y2BE31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE31"/>
    <dbReference type="STRING" id="71784.A0A1Y2BE31"/>
    <dbReference type="InParanoid" id="A0A1Y2BE31"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="188"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="571" mass="62449" checksum="F9744CFC5A09318A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEJ0</accession>
    <name>A0A1Y2BEJ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_464383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEJ0"/>
    <dbReference type="FunCoup" id="A0A1Y2BEJ0">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEJ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BEJ0"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14096">
        <property type="entry name" value="STKc_RCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000425">
        <property type="entry name" value="Putative calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="514" mass="57404" checksum="9440C252F9AEA4DF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF07</accession>
    <name>A0A1Y2BF07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_464056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF07"/>
    <dbReference type="FunCoup" id="A0A1Y2BF07">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF07"/>
    <dbReference type="InParanoid" id="A0A1Y2BF07"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="553" mass="59941" checksum="1590489C91F9BD47" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFK6</accession>
    <name>A0A1Y2BFK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin motor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_586784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFK6"/>
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    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000143">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="173"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="907"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1371"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1425"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1475"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="521"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1318"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1013"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1375"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="262"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1503" mass="165794" checksum="15E35642AA75240E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFQ0</accession>
    <name>A0A1Y2BFQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_463713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2BFQ0"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="446" mass="49754" checksum="B11A9AA3C0302915" modified="2017-08-30" version="1">MSLPNLIAHYLATNYPSVLDAFVQAAHIAPPDVTQPPNPDLRTLLSDWQSQQVTERLEAVTIDENAEGWQKWKLRDFTKIAMSPEEKLLGAKRTLEGITAANLLTVQVQHVPKRVFDLASASYIASRPLSILTSSVDKTLRIIDYESGEVDRIIEPHRAAILSFALHPTNPRYLVTGSMDGTTVLTDLITSQTLQTWKSGKFVVRVAFSPDGRFLATASYDRNVVVYEALATAEPDIPLDETDDAALACEPDLRYEEKHRIKVDSNPEAILFHPMSEWLMYTLRESHQLYYVHLGSWQVRTKSFNPHPFDTHVSFSVLNMALHPSGRIVACQTGDHRGGSGERILLYGIEPDETERLACVWTGHEGDDFVLPRMAWLPDGSGFITTTPNGYLHLITVTGETRSSIKIHGAEYGATSEVVRDCSVATVEGGWEVVSVGYDRRVRISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG12</accession>
    <name>A0A1Y2BG12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_518959</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG12"/>
    <dbReference type="FunCoup" id="A0A1Y2BG12">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BG12"/>
    <dbReference type="InParanoid" id="A0A1Y2BG12"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="645"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY33742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1013" mass="113548" checksum="D5E77F3C34495ACE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGI3</accession>
    <name>A0A1Y2BGI3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_563820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGI3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGI3"/>
    <dbReference type="InParanoid" id="A0A1Y2BGI3"/>
    <dbReference type="OrthoDB" id="9997422at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="537" mass="59842" checksum="88CFA16AC973E0ED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHL1</accession>
    <name>A0A1Y2BHL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_517430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHL1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHL1"/>
    <dbReference type="InParanoid" id="A0A1Y2BHL1"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="76"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="498" mass="53990" checksum="EDA335741123EBC5" modified="2017-08-30" version="1">MLPPPFPPQSRLTTASGPPLTPSQTRQEDAPLDYDEWMDGGDGGGGGDGGGGGESTGVVDLVYTAPALLQSGMFAGKWMRFSLVLAQQPVVGRRKTEKDRRPIAHCPILRLHAIECFSPNPSQAGFDGIPFDMVKIEPVHLLCSAELSLPEHPARSTWSYEPSPSPRMSPPSPLPHYGGSDPPPEFSKPPSSDAESSLGTSWASEDFAGPSTLYERQRQNTVPNYNYSPNLEPNPNLSPLSNGRRRRQSQDISMTDSRPASRDSRRTVGSPFEDSRNLYGSLHVTGVRVPVGPSDNTLGIWFLFTDLTVRHEGTYVLRFRVFDLSATDGETQGPIPHLAECESQSFKVFAPRNFPGLPRPTEVAEHFTRLGFKLNTRKNERQAKTPPPLPPQPRPTSRDRHRRPPLTSSTTTTTTTTTTTTTATTTNNALSGRRPLASPLQHENQSSKHGHGSQPSSAESASASDWDLNEAGTSGDGAGATDTTGTSYSGAGFRWQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHM4</accession>
    <name>A0A1Y2BHM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GrpE protein homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_517515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHM4"/>
    <dbReference type="FunCoup" id="A0A1Y2BHM4">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHM4"/>
    <dbReference type="InParanoid" id="A0A1Y2BHM4"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="228" mass="24848" checksum="5AE7C7DA1A8F8287" modified="2017-08-30" version="1" fragment="single">MNPRSLATQFRNLPRSAALTRPARKPLTVPRYSPASAFRSYSDASESSTASAEGAAKTAEVQAAEEKAAALEAKIKELERDVLYHRAEIQTLNRRIADEKAKASEFAITSFARNLLSTSDVLTKALSHVKTPISPDNPDLHNLYSGVELTHKAMLKTFEQHGVKKMEVERGGSFDPNMHEATFQIPKEAAGPKGDGEWGPGEVVEVGKEGWTIGNRVLRPAQVGVTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHQ6</accession>
    <name>A0A1Y2BHQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_463127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHQ6"/>
    <dbReference type="FunCoup" id="A0A1Y2BHQ6">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BHQ6"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="467" mass="49610" checksum="7B60313125429D93" modified="2017-08-30" version="1">MRSSPKITLSIGKPPTLVEADSEVSASWTCGVCGYVNALSPTEGVPSPAAKCGLCGVGFSTSRSSSSLPTTRSGTPQPIPAIPAINEDPDGGIACPACTFLNHASLSHCEICSTPLPSNRKRTVASVASTSAVQQNGGDVALEVVRLSFRNGGVKEAYRRLKNVLGSKSWERQVNPSNTSADSTDGAMSTPRAGAGIGVDGILQSMSLDAKSQDDDMQTAFKDLEVLMVRAGEMVRMAQSLNAKLTAQQQSSNTPSDEETTLIRTSLVQLGLPAPALTQDMVKDDRRYFDGLAKELGGLLTGRPGDRETQGLMVGRQGRGVIGLDEVWGLWMRARGVSLLPPSTLISILPFLPQHTSPQIRPLTLPSSLMVLYSPYYAPLNLLSRILALLTPSPTSIQEPSLSVIDISAHEGLPIGLAKEFIEQLETTRVHVLPGSQEASGLVRDDQAAQADGGVRWYRDIISGWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIJ5</accession>
    <name>A0A1Y2BIJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_513576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIJ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIJ5"/>
    <dbReference type="InParanoid" id="A0A1Y2BIJ5"/>
    <dbReference type="OrthoDB" id="2555515at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="63627" checksum="72AF11E11CFB5FDD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJD2</accession>
    <name>A0A1Y2BJD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_515313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJD2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJD2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJD2"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="393"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="439" mass="46181" checksum="8A2FD7A32A473818" modified="2017-08-30" version="1">MSYIASAMNSASYATNTSDDRDNSNGFEFTRRKRWPSLLLQELVGSALFCLKPIPDQRSSVDPNNGRPESTLGWKILFASPSAQEMLNQKPSELEGRDFFDLVFTPDHPQLQVLFLSLLNPGHPPLAHNSDSSASNSTDSSGGLGFGQPAIFSGPSGAGRTQTAYVRILAASEPSHPGTSSVATIGKGSSSSSSSSSGPVVWELRAHATGLDGPLFGGPAFGMAGQGTVEPQSQGNEGSLRGKAVWVMGRKVGQGQGEAESNGTSQSLDAFLELKLENERLREELQELQLDLDDDDYSRPVYVDPAPIPIYNPDDSDSVSDSSDSSTNGDAGTGTGGGGGGGTGGAGEGSSNSSPRAKPSNKLLKDPAQRKKKKTSMGMSRPSGQEGEGMHVCVSCGRTDSPEWRKGPLGPKTLCNACGLRWAKRNSVAPSKKDKKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKA8</accession>
    <name>A0A1Y2BKA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1445 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_516339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKA8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKA8"/>
    <dbReference type="InParanoid" id="A0A1Y2BKA8"/>
    <dbReference type="OrthoDB" id="10262538at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2040.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2040.10">
        <property type="entry name" value="PSTPO5379-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="D-Glu_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29942" checksum="1E429414713ADFFE" modified="2017-08-30" version="1">MPFIQDGPDASLTAAAVRQLCRDNELPTPSTAGWAPDCAQANIVILPAKYADDFRTFCLRNPVPCPLLGETKPGDPTVPSFLAKSSDIRTDCGRYNIYKDGQWVDNKTDVMEEWKDDSVAFFIGCSYSFESALVANDLPLRHQEIHKMTPCYKTSVQLMQAGIFSGRMVVSMRPYPADRVSDIQAITRSFSKAHGEPVGYGPEGAAKLGIQDVDGQKPDWGDATVMKEGEVAVYWGCGVSPQQAVLDSKIPGTVMCHQPGMMLVLDLKAKDVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL45</accession>
    <name>A0A1Y2BL45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HSF-type DNA-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_9987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL45"/>
    <dbReference type="FunCoup" id="A0A1Y2BL45">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL45"/>
    <dbReference type="InParanoid" id="A0A1Y2BL45"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="683"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="467"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="603"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="917"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="938"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="966" mass="102513" checksum="970A1603622B82E4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLD5</accession>
    <name>A0A1Y2BLD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_137700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21022" checksum="8907ED64EEC74942" modified="2017-08-30" version="1">MFNDIPCQFKVDVIHIIDSLRAMPTLSIPTSLPPGALYLTYKSCSTWPLPSHTGTSSDSPVHISILDSSFNPPTLAHLAIASSDPPPSSPSSSSSSSSSLPYTARLLLFSIRNVDKKPQPSDPSLEQRLSMVHLLAQRIPDLPIAVGILDEPTFAGKSHVVHNFLKTISTSTSSTSTETTTTTTTIGDRNILHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLE6</accession>
    <name>A0A1Y2BLE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin, light chain 2, 20 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_21872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLE6"/>
    <dbReference type="FunCoup" id="A0A1Y2BLE6">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLE6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLE6"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="192" mass="21394" checksum="C50F5F504280867F" modified="2017-08-30" version="1">MATKAAQLGLGQASTVPKKSSVDRREPSGGAFTMFTGPQVKQFKEAFNMIDQDGDGRVTESDLKIMLSNLGQTPTSTLLDNLLSTRQGNDKSQGINFTQFLTMMGEHLLELDPEQDLIDAFACFDDGDKGFVGVAEMRKYLGEMGDRMDDREIDRLFSGQFTDRQGRFNYLEFAKVLKVNDGEPERDDKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLJ9</accession>
    <name>A0A1Y2BLJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_511282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLJ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLJ9"/>
    <dbReference type="InParanoid" id="A0A1Y2BLJ9"/>
    <dbReference type="OrthoDB" id="3262547at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="573" mass="60415" checksum="B04A4BC1020C93B7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLR5</accession>
    <name>A0A1Y2BLR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_511706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLR5"/>
    <dbReference type="FunCoup" id="A0A1Y2BLR5">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLR5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLR5"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="411"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1146" mass="130485" checksum="5962191167DEBB55" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM29</accession>
    <name>A0A1Y2BM29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_35392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM29"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM29"/>
    <dbReference type="InParanoid" id="A0A1Y2BM29"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Wax synthase" evidence="5">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="212" mass="24438" checksum="163C6E4449DAC02C" modified="2017-08-30" version="1">MRFGFLQVTFYSSATRWAFSRSPPSLYPLPHPPPFPPARFLRRTTLFKSIDLLCNENRLINISPYSPPLKSSNISWFRYTTYHICMFSVHFLIYDMTTLPLALLAPDGVGDTFGGGGDYELFLGEMRHKYGVPELLSRMIWTLELGFTVYNGMAVMYHGFAMFSIGSGVWCGEEWPKLMDKPWLSTSLSELWGKRWHQTLRVSRHDTSLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADF7</accession>
    <name>A0A1Y2ADF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_567346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000130">
        <property type="protein sequence ID" value="ORY20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADF7"/>
    <dbReference type="FunCoup" id="A0A1Y2ADF7">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ADF7"/>
    <dbReference type="InParanoid" id="A0A1Y2ADF7"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011818529" description="Protein kish" evidence="9">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="71" mass="7824" checksum="0777D4E669FD2170" modified="2017-08-30" version="1">MTALFNFQSLLLVFLLLICTCTYVRGAAPGLVDRNREGFMGVFFKCARIGERLSPYVSLACIIMAVSMIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADZ2</accession>
    <name>A0A1Y2ADZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_488725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000125">
        <property type="protein sequence ID" value="ORY20788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADZ2"/>
    <dbReference type="InParanoid" id="A0A1Y2ADZ2"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY20788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="558" mass="61749" checksum="DA6A455E6187CBAF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEA1</accession>
    <name>A0A1Y2AEA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_554477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000122">
        <property type="protein sequence ID" value="ORY20908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEA1"/>
    <dbReference type="InParanoid" id="A0A1Y2AEA1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY20908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="372" mass="41287" checksum="2C1D2B50F5C3DBF6" modified="2017-08-30" version="1">MIETTSTRYSPQERFRIVGADYSDGHLIDDRHFIRSLQDVERVARGLVFSASASRPSNEAVYHRLRSFERNKVYEIVLDHDTRAYGFVTPAEPDIVHLRYDVSDVGLSNPISNGNITDGRIIDTWHIRTSLISIVAVLAVSQAAPGQTRFQRTLSSRSGICGGSPSSRAHSCGEDDGCGDHQANFTVGSCGELTRLSCTLRRRGVGFREISIRRPDERELAGPDGFTAFSAGFNCMFLDELLSSANLLFSQQGTVKSLAIETSMGHILLPKRVIKNLYKQKNENWQESLPLRPTSESDYSHGASLRYIDLAPNEVDDFGMETPPVVPCQQGEPSLRYSDLLPNQVEEMGAGEIEVPLVYHQPYEPRGGPCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEM9</accession>
    <name>A0A1Y2AEM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_502279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000119">
        <property type="protein sequence ID" value="ORY21038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEM9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEM9"/>
    <dbReference type="InParanoid" id="A0A1Y2AEM9"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY21038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="288" mass="30257" checksum="E9388E07FD1EF954" modified="2017-08-30" version="1">MPLDLSSLSAVNLYNVRNKWTVITGGGSGIGRTLASAYAVNGANVIITGRRKEVLEETAKELNEAISQGEGKVYPVQGDVSSKEAVAAMASAIGQVTEVVDVLINCAGLLKPWRKQCEVDDVENLQSMLWDGVEDDDFVDMSRVNVNGVYFTTVAMIPFLRRSTLPVVINIASLAALGLQRRGSSVTLGATKAGTLHLTGLLASRLIPFKIRVNAVCPGLFPSAMTGDGKTLAPVLSEAVKVSPVGRAGRPEEIAGPVLMLGSDAGSYMDNAVLIVDGGRLITMSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFN2</accession>
    <name>A0A1Y2AFN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycerol-1-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_562719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000115">
        <property type="protein sequence ID" value="ORY21254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFN2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFN2"/>
    <dbReference type="InParanoid" id="A0A1Y2AFN2"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="238" mass="25800" checksum="30BC3C8D817F15AA" modified="2017-08-30" version="1">MPSDILKADAILFDLDGTLIETTSAGEIAWAQFASEYNFDLQESLKNSHGVRYIERLRVWCGITDPDILQAELRRYEDLEVKIAKEQKERGEGGFVLTPGAQRILSKLQSSGHANWAIVTSCTRYLVEQALPAAGISPPPKLITADDVVNGKPDPEPYLTGAASLGVDIKRCVIFEDAPAGIKSGLSSSATVLAVCTSHALKDIRQAGPDHVVKSFEHVDVTVLEDGEIELSIDVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG93</accession>
    <name>A0A1Y2AG93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_569544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG93"/>
    <dbReference type="InParanoid" id="A0A1Y2AG93"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY21526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="515" mass="56680" checksum="9EC7C56751840EFF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGH2</accession>
    <name>A0A1Y2AGH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_52533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000106">
        <property type="protein sequence ID" value="ORY21693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGH2"/>
    <dbReference type="InParanoid" id="A0A1Y2AGH2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25471" checksum="F8448D40CA416F68" modified="2017-08-30" version="1">MCPLFVKEWMFCGPSVVLTPYLFKNRLDNGSKTLDPLSLPCASCPKLVLGPFQRFLSSHTFASTLPFHLSYLRNFIGRAVMSLGELGKSEQLAVPPSLVERGYIYEIRTPLDCRKAWPEGQTVDNHGRSSFITYRIRTDPSSSGADGAILRGTAEELYTNIKSGMGPQTLLAHGLSDSGKSYSFTRLMESLLEHLQTHSSFDLSSVPGHVKSYSELMDVFGSAQMPSNAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGK1</accession>
    <name>A0A1Y2AGK1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000111">
        <property type="protein sequence ID" value="ORY21420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGK1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGK1"/>
    <dbReference type="InParanoid" id="A0A1Y2AGK1"/>
    <dbReference type="OrthoDB" id="2538408at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="37254" checksum="F33E99F52C1D5621" modified="2017-08-30" version="1">MNDSVTTKAIYTVFTSPHHAPMPNHLPTLIVTPHGQPNQVLYTYLHTEENRVNYLLTPSPQGDLCVAKLFPPNRRTPPSGSSTSISNKPASVVRCEASRDLRWTIENTGVMSPIYKIVNQDDTPLYQISKPNPNAEFWTMFYFKYAGHQIPPRRVEFGKVAKNPAEKGGGTRITITGKSEDEKQVWQTLGVGNEDCVEWVVCCACLNLLDDQILQAAEKKNAANLPPASTAPIAPAATSLRPSPAASPIPRLNGHTPPSRGPGIASTAPAPLASNLAQAYRQNPPPQMQLRAPPASSSSSSAPASSGAYRPPLPSQVAGGGGMRAPPPGQNRPNVLSRAPPAGTGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI93</accession>
    <name>A0A1Y2AI93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trimeric LpxA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_567108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI93"/>
    <dbReference type="FunCoup" id="A0A1Y2AI93">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AI93"/>
    <dbReference type="InParanoid" id="A0A1Y2AI93"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY22192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="225" mass="24534" checksum="6874E1FAB3BD2857" modified="2017-08-30" version="1">MSEMKMDNSVQKNISREDQFALRKGRSEPECMVLGAGLPYRPNDDRTLVDGRLAVKAHMKAYNEFPWPQSPDSYFGPNARQALLGKVFGLTLEEIIGRPIEIEPPFWVDYGTRIEFAGSFYANTSLVILDAAKVKIGTRVLCGPRVGIYSASHSSQQSGFDRAYPVEIGDDCWLGAGCIINGPTKIGKGCTIAAGAVVRGTFPDHCVIGGVPARILKFLQPPQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ26</accession>
    <name>A0A1Y2AJ26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_591273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ26"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ26"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ26"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF19">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY22578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44750" checksum="1520660B0D9E2AED" modified="2017-08-30" version="1">MSAYWISHSSPDSHIEQHYPLRTPPSRRHATDPSSRSVRDLNPFPSPPISTTTSPTLYLDSIQSAETPPGEDPDPWKIVFNMDLTAGETSTGGGMAGSWRVEGSQELTRRLTSHSSSVAEEQPEHDEGVWGVPQPQPHLNPRRRWASPTRVTGSGIGEIKHVGPLPIAVWASVMDTSKGRDKVLKCLQYSLRTYLYLLSLVAAVRPLSPWFKANSKRMRIAVSGLSLTRKCLLLLNPLHPLTHLLSPEPTSAPTLIRHLIDLASSLADDLYCLSRLGIVGKRTGKIADRWANRFWLLTTLMALYTLHLRTLPRLALSSTAAPESISPSSNEVVDSQSPVRTKSKARRDAEWTGRKLLADLVFVSYEVLELSWMKEPVQCVMGLCAAFISSGKLYDQHWAAGLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJR4</accession>
    <name>A0A1Y2AJR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_390643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJR4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJR4"/>
    <dbReference type="InParanoid" id="A0A1Y2AJR4"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY22185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="506" mass="55019" checksum="DAE4C5DCA0FA9A2D" modified="2017-08-30" version="1">MEIKHDDKPLTADASTSIVDSHPYTTPHLKRNITALSIVGLSMSICNGWAAMSSTIVIGLSQGGTPVILYGLIFTSIINVFLALSLGEMASAYPSAGGQYVWASVLAGPRTRRGIAFTVGWTNIFSWLTIVASVVIISAEVIFALVQTYNPDFVIQRWMVFLVFEAINVVSLCFNLFALSNLPRMGVFFLFFSTAIFLTVLITCLAKAPTYQSNHFVWGTYTNGIDWTNGFVVVVTGLVNPAYVFAGLDGAIHIAEECLNPARAVPYALVCTVGVGFLTGFVFSVGLLYCVQDLVSATDSELPFLTIIVQATNSKAAGAVFMSAFLVVLMVSSNSVHQATSRLIWSFARDRGLPYSSQVARIDPKLHVPVIPLLISFTGVTILGALYVASTTVYNSIIACCIILGNISFSIPAVQLMLRGRRMNPNRWLKLGALGWAANIVTVVWTIFTTVMWLFPITPHPDAADMNYSVVVLVVMGLIALLDWVLHGRKHFVGPKLEDVQSHMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALD5</accession>
    <name>A0A1Y2ALD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGS domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_549492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALD5"/>
    <dbReference type="FunCoup" id="A0A1Y2ALD5">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALD5"/>
    <dbReference type="InParanoid" id="A0A1Y2ALD5"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="56"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="179"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="273" mass="29998" checksum="9B8A4177A812B8B0" modified="2017-08-30" version="1">MIFLNFSQTSTLTVLARSRITDKSRIFSFSVSVTTFSSLDLESLDIDQMSASITDAPLPRYDFYQTPVHLIVSLYVKGYNTPELSEVVEVSFKSHSVEIFLPPLPGSSAVVKTRLNLSPLFAPIQPEESTFRLLSTKIELKLIKVDTETWPALLSTPTVPSDAGPSRSTQLPPTAQAPVVQEKKDAKRRNWDKILSEDELEDKSDSSDPNAGGDAALQSLFSKIYADADADTRRAMIKSFTESGGTALSTDWSDVGSKTVPIRPPDGMEAKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALH1</accession>
    <name>A0A1Y2ALH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphoethanolamine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_549196</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALH1"/>
    <dbReference type="FunCoup" id="A0A1Y2ALH1">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALH1"/>
    <dbReference type="InParanoid" id="A0A1Y2ALH1"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="806"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="836"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="934"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="12">
        <location>
            <begin position="899"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY23418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1053" mass="115100" checksum="91530ED3768CE001" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALI0</accession>
    <name>A0A1Y2ALI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_549240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALI0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALI0"/>
    <dbReference type="InParanoid" id="A0A1Y2ALI0"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="395"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="591" mass="64982" checksum="9196C5850F45C03A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALR9</accession>
    <name>A0A1Y2ALR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_561949</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALR9"/>
    <dbReference type="FunCoup" id="A0A1Y2ALR9">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALR9"/>
    <dbReference type="InParanoid" id="A0A1Y2ALR9"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="34"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="330"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY23434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="485" mass="53590" checksum="838BA1774FE3EFF5" modified="2017-08-30" version="1">MATTHVISTSNPANLLSSTGSHSSSSSNIVGVHYKVGKKIGEGSFGVIFEGTNLLNSQSVAIKFEPRKSDAPQLRDEYRSYKILSGCMGIPQVYYFGQEGLHNILVIDLLGPSLEDLFDMCGRKFSVKTCCMTARQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGSKGANTIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFFYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTPIPELVEGYPQEFAIYLNYVRKLTFDETPDYDFLRELFLTAIKNNGDEEDQVYDWMLLNGGKGWETSSSTAAVADVNRRETTRRPEKDRMDRLRTNASGGPGSPLKQRKSAAGSGLPNASNQAIVGVSAPSPLPTSRRQSSQNHPFANVNALHPADRNGDSYDPSNVAVQSQAGMQPIAPMTVNGRPGNTAANSQQLGEGDYHQDRKKSGGFLSLITCGCAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMY0</accession>
    <name>A0A1Y2AMY0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_500558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMY0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMY0"/>
    <dbReference type="InParanoid" id="A0A1Y2AMY0"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="213"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="292" mass="32558" checksum="2DE5404E5385A1FB" modified="2017-08-30" version="1">MSLNISSTVRLASGTRMPQYGFGSPSAQFTYDAVTEAIKTGYRHFDTAQMYGNESEVSRALHDAIASKIVTRSDLWLTTKWNPPQPLSEPGVQTDKVYAELRASYDIFIKDAGLEYIDLMLVHQSRPGPQGRANHWRALVRAKEEGWVHEIGVSNHSEIHLAALPAPTPAVNQIEIHPWMQQRPITSYCKAHNIHLTAFCPLVRIDPLRVADPVVVRICQKHGKEWAQVVLRWSLQKGYSPIPQSKSAARIHSNADLFDFELSPDDMEAMEALEVGDEAAASKAALKEVRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APT1</accession>
    <name>A0A1Y2APT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_547553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APT1"/>
    <dbReference type="STRING" id="71784.A0A1Y2APT1"/>
    <dbReference type="InParanoid" id="A0A1Y2APT1"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="83"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="331" mass="37742" checksum="581DE62949C0F3F8" modified="2017-08-30" version="1">MADTELNSKTPFDRTEKTIKGYGPTHPSGKWPGGAKVAVSFCLNYEEGGEYSIRNGDKFHQRDFHEYENRLTSDMPRVGIVDPAMESQYSYGSRAGVWRIYEAFRKRDMTLTLYGVAAALKCNPKVTQLAVKYGFECGSHGSRWIQHATITPEEEAAQIREGIKIWASQGPVPVGWFLGRPSKLSAYLVHEEYKKAGLPPLTWWSDLYVDDVPHWRPRPGGKKDEGMLCLPYSYDNNDFKFSQPAGWRSPKIYEDHLIAAFDELWAEAERSGTDKMMTIGLHCRVIGKPGRIGALERFLDHLKAKGAWVTTRQNIAEHWMKLYPYDPETAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ26</accession>
    <name>A0A1Y2AQ26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ26"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQ26"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ26"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010991865" evidence="1">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="185" mass="19027" checksum="63186EFB5C78E642" modified="2017-08-30" version="1">MKFIALVAAAVAASVVVAAPVPEPSVKDACFGPSCGSYPWKREAAPAPEPSVKASCFGPSCGSYPWKREAEAAPAAEAEPSVKASCFGPSCGSYPWKREAEAEAAPEAEPSVKASCFGPSCGSYPWKREAEAEAAPEAEPSVKASCFGPSCGSYPWKREAEAAPAPEPSVKAACFGPSCGSYPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARK1</accession>
    <name>A0A1Y2ARK1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_471711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARK1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARK1"/>
    <dbReference type="InParanoid" id="A0A1Y2ARK1"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="474"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="581"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="671"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="927"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="950"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="973"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY25162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1135" mass="125245" checksum="D9C50491688C1AAF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARN5</accession>
    <name>A0A1Y2ARN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_600351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARN5"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARN5"/>
    <dbReference type="InParanoid" id="A0A1Y2ARN5"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="464" mass="50362" checksum="9597221A80E990EA" modified="2017-08-30" version="1">MPHPVAVPIKIGYPSTAKELSTAGRSLFYRTKTVPPLAVSGDGIYIHTADGSTVIDAFGGACVIDAISTQVATLPFVYQWSFTSQPAEDLAEYLIAHSKGYFETVNFVSGGSEANESAIKLVLQYFFLRGETQRRNFIGRDMSFHGNTIGALSLGMHKERRLPYEGIVNHGTFHHVSPCLPKHNMLPVETEDEYSTRLAVELEEKILELGPDTVAAFFAEPMVGAAAGCTKPVKGYFPKIREVCDKYGVLLVFDEIMCGMWRLGTMFAFETLGEGVSPDIMTCGKGLGAGYVSVGAMFVNKRVMQGIREGTGLSAGLWFSGHTYVGHPVTCAGALAVQRAIQEDGLAARITPLGKLLEKIIRTRLLESNSPAREAILDIRGQGLFWAVEYKSSCQRDGELPFSEKVKKISMSKGVVVSNAPDTVAKHVGDVNMIAPAFITTEVQMEVIANVFCDSVELAFVSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS84</accession>
    <name>A0A1Y2AS84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_485428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS84"/>
    <dbReference type="STRING" id="71784.A0A1Y2AS84"/>
    <dbReference type="InParanoid" id="A0A1Y2AS84"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="398" mass="44924" checksum="38AB655AD989B860" modified="2017-08-30" version="1">MSKLFAQLPFDPTISVTPYNIAVPEETLEDLKSALDTVRPVKTTFENTNLGNGAGVTKEWIDNALKSWKNEFDWREIESELNSYPNYLAHVTHKDEKLDVHFIGLFSNRKDAVPVIMSHGWPGNIIEFVPVIRYLTKKYTPETLPVHLIVPSLIGFGFSAPPPLTKEWTNLDTATVFDQAMRGLGFESYLAQGGDIGSYISILLGDRFEACKAVHLNMIIIDPPADLDRSALTEKDKAALERYEWFENWEFAYAQEHATKTSTIGMVIGSNPIALLAWIGEKLIVWSDETPSLDLILANISLYYLTSTFPTSLYHYRTSTGPNRVNSAIPRGLKGKPLGFSHFPKEIRPVPLAWIEADANYDVSWFRAHEKGGHFAALEQPESFWSDVEAFIKEKWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASA6</accession>
    <name>A0A1Y2ASA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_544974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASA6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASA6"/>
    <dbReference type="InParanoid" id="A0A1Y2ASA6"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="169"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="523" mass="57391" checksum="75D501F219A6D68E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT55</accession>
    <name>A0A1Y2AT55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT55"/>
    <dbReference type="InParanoid" id="A0A1Y2AT55"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012214844" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18412" checksum="F38F54C4CF4F21A3" modified="2017-08-30" version="1">MLSKTYLFGTLLALGVVFADEEVAYRFFSPWNPNVQSRDCIALSTSLGEAQAGDSLALKGCEDSAEMRWTLNPPIDTVDIQEGIFPPLPDWTGTINIWGTDLSLMVNDDGNLVLGHYDSQPSSKSLQWSLLGSPSPEANLQSSATSKCLSQAGWGFNFVDCHPGQEYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATH3</accession>
    <name>A0A1Y2ATH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_543033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATH3"/>
    <dbReference type="FunCoup" id="A0A1Y2ATH3">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATH3"/>
    <dbReference type="InParanoid" id="A0A1Y2ATH3"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="45"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="441"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="498" mass="53896" checksum="0AAA7BFBF660804C" modified="2017-08-30" version="1">MLARTSLRTASSLTIRRTPIVAARTFSSTMMAPQKYREEKDTFGPLQVPAERYWGAQTQRSLQNFDIGGPTERMPPPLIHAFGVLKKAAAHVNQEYGLPADVAEHISKAADEVISGKLIDEFPLVVFQTGSGTQTNMNVNEVISNRAIEMMGGQLGSKKPVHPNDHVNMSQSSNDTFPTAMHVAAVTEINASLLPAMQELHDALEEKRKSFEDIIKIGRTHLQDATPLTLGQEFSGYVTQVERGIGRVKSTLKNLSMLAQGGTAVGTGLNTKKGFDVKVAAEISKITGYEFITAPNKFEALAAHDAIVEASGALNTVAVSYMKIANDIRYLGSGPRCGLGELELPENEPGSSIMPGKVNPTQCEALTMVAAQVMGNHTAITIAGSYGQFELNVFKPVLIKNLLQSIRLLADGSRSFTKNCVVGIKANEERIKKILNESLMLATCLNSVLGYDDVAKIAKKAHHEGLTLKESALALGAISEEEFDKRVRPELMLAPDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU77</accession>
    <name>A0A1Y2AU77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Membrane-associated, eicosanoid/glutathione metabolism protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_270191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU77"/>
    <dbReference type="InParanoid" id="A0A1Y2AU77"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15214" checksum="CFF0016054D317A2" modified="2017-08-30" version="1">MHWNRMAPLVWAVNTTNTAAPGAYDNSMPRDSWKSLKGKIPDKLYGRVTRAVAANDNSHVNLSLFAAALAAANAAHVDSTSLHICSATYLVSRVAYNLAYVFIDDEKYASLRSGTFWIGAITCGVLFFKAADKMKSLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUM2</accession>
    <name>A0A1Y2AUM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_541619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUM2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUM2"/>
    <dbReference type="InParanoid" id="A0A1Y2AUM2"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012078872" evidence="1">
        <location>
            <begin position="16"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="385" mass="41831" checksum="031E98A07C830A2F" modified="2017-08-30" version="1">MRFFSSLPFLSAVLPASFLGNNDDAIKPLTISAQGINATFIGHGARLTHLFVNDRDEKPRDVVVGYDDPAQYLIDTATSRTFYGSIVGRYANRIKNGTFAIGHSTYHVPENEHGGLNSLHGGTLGYDGVNWTLAHHSKSSITYALLDPSGSEGFPGVLQTYVTYTVLANPARMTARIVSIPFDQATPAMLSTHIYWNIGAFSQPTVLNDTLHLPYANRIIEVDSLSIPTGALESLIYPWSDPVSPLNFTSPKTIGAGLSDQCGAGCHGIDNAFILDRPTFAAADDTTLPMLNWYSPDTGISMTVRTNQGSVQIYNCVGQDGSVGNKASQQQSGVKTVNKYGCLVIEPQQWIDGINHPEWGQLDKQIFGPDTGVMQNWAEYEFGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUU4</accession>
    <name>A0A1Y2AUU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_589774</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUU4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUU4"/>
    <dbReference type="InParanoid" id="A0A1Y2AUU4"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013276972" description="Beta-hexosaminidase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="12">
        <location>
            <begin position="51"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="11">
        <location>
            <begin position="259"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY26256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="643" mass="70896" checksum="35C36DC060856ED4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUZ6</accession>
    <name>A0A1Y2AUZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_541800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUZ6"/>
    <dbReference type="FunCoup" id="A0A1Y2AUZ6">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AUZ6"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
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    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="437" mass="49813" checksum="BDBA811349332841" modified="2017-08-30" version="1">MDVEPNSQWRFAQCFGDKGEVEDITEADIISTVEFDHTGDYLATGDKGGRVVLFERNEQKRGCEYKFYTEFQSHEPEFDYLKSLEIEEKINRIKWCKRQNAAHFLLSTNDKTIKLWKVFDKQIKVVAENNHSEGFPPNGAASQPLPRLPRMAAHDSITAAVPRKVYANAHAYHINSISVNSDGETYISADDLRINLWNLNISDQSFNIVDIKPVNMEELTEVITAAEFHPIHCNLFMYSSSKGTIKLADMRESALCDQHAKLFEEEEDPTQKSFFSEIISSISDVKFSRDGRYILSRDYLTLKIWDIAMESKPVKTINIHDHLRGKLCDLYENDCIFDKFECTFSGDGSQVLTGSYHNYFRIYDVNGDNDVVLQADKSAFKAKKIGGARNKAPGKKEGLQTENIDFAKKILHASWHPRENTIAIAATNNLFLYSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV26</accession>
    <name>A0A1Y2AV26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_560592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV26"/>
    <dbReference type="STRING" id="71784.A0A1Y2AV26"/>
    <dbReference type="InParanoid" id="A0A1Y2AV26"/>
    <dbReference type="OrthoDB" id="2596883at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="632" mass="69204" checksum="2910EBDBB683856A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV68</accession>
    <name>A0A1Y2AV68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_541392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV68"/>
    <dbReference type="InParanoid" id="A0A1Y2AV68"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="189" mass="19862" checksum="AFFDCA369184AF2F" modified="2017-08-30" version="1">MGILDWFPCCGPRRKDDESSTLLPPSSSLTAPNRPESIISSSDTGLANGYGSVDRGGVGGGMTEERRRRIEEISRDVGSQMLPIHLPLPRNQPPSPTQPSQTHPSASHPATSTSSTTSSRPSSPSPLRPETSPPGGVLRTPEASEYGEAAKDEDGVVRKTLFLNPPGGSGGRRVSGRGRGRGRGRGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVB1</accession>
    <name>A0A1Y2AVB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p115 like vesicle tethering protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_542010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVB1"/>
    <dbReference type="FunCoup" id="A0A1Y2AVB1">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVB1"/>
    <dbReference type="InParanoid" id="A0A1Y2AVB1"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="438"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="875"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="892"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109324" checksum="51DB1D77340746A0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVN7</accession>
    <name>A0A1Y2AVN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formin homology 2 domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_589681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVN7"/>
    <dbReference type="InParanoid" id="A0A1Y2AVN7"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="2">
        <location>
            <begin position="543"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="1196"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1715" mass="188053" checksum="CA25F25F067B3AF9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWE0</accession>
    <name>A0A1Y2AWE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_539919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWE0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWE0"/>
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    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="41"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="651" mass="71022" checksum="E2FE8FF7CD4D5309" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWG2</accession>
    <name>A0A1Y2AWG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epidermal growth factor receptor-like transmembrane-juxtamembrane segment domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_261379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWG2"/>
    <dbReference type="InParanoid" id="A0A1Y2AWG2"/>
    <dbReference type="OrthoDB" id="2591431at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049328">
        <property type="entry name" value="TM_ErbB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21314">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Epidermal growth factor receptor-like transmembrane-juxtamembrane segment" evidence="6">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="467"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="467" mass="46700" checksum="B7609ECB8351A865" modified="2017-08-30" version="1">MNVAVGSSSNTSCLNDNLLYDFFFSIDPQTNPSQCSSMAISWNDNVTYPLHLYGLIPSGSAFEVSVPQTSSDVDIDWTVDIRSGTDFLLLMADSGTYQTGGSSSLLTVGSGDGSCINSTSPASATPSSSTSSSARSSSSSTSSSASTSPVTSSSSSTSTSTSSSAGVTGVGGGSAGGTSGNDSSGSGTGSSGSSKVGPIVGGVVGGVAFLALLALLAFCCVRRRKRNDSRKENDPLLSAYGASSGEKPGRRRPVDLLEEGGGGVGIGATRHDSGETHVEGQTGGYEVTPFRGGYPSPGLSHPEMAAVGGVAKADEARTPTGLESSTPLRPSVDSNREGTTASSGGGTFGTPSRTPQAQSTLAASDMATVGHGSAGEGGGVGGLAGLGLGTLGVVGGVERSNSIRKPASASTLREREPELARPLPAAPRFVQHEDSGRVREVGGGGDVGEVVDLPPRYDQLLARNPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWP5</accession>
    <name>A0A1Y2AWP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microcystin LR degradation protein MlrC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_539663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2AWP5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWP5"/>
    <dbReference type="OrthoDB" id="4131805at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009197">
        <property type="entry name" value="MlrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010799">
        <property type="entry name" value="MlrC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015995">
        <property type="entry name" value="MlrC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07364">
        <property type="entry name" value="DUF1485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07171">
        <property type="entry name" value="MlrC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012702">
        <property type="entry name" value="UCP012702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microcystin LR degradation protein MlrC N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Microcystin LR degradation protein MlrC C-terminal" evidence="1">
        <location>
            <begin position="308"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56022" checksum="E7707A9D5FDB11F3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWX3</accession>
    <name>A0A1Y2AWX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sodium bile acid cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_594675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWX3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWX3"/>
    <dbReference type="InParanoid" id="A0A1Y2AWX3"/>
    <dbReference type="OrthoDB" id="188035at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="421" mass="46455" checksum="81072B460EBBF3CD" modified="2017-08-30" version="1">MPADAPGKERSRLRSTLLIARSIFDFLLGQWLLIAMGLVIMLAYFFPSVGKRGGHVASQWTVTYGAVIVIFLISGLSLPFDKLVLQARNIRLHLIVQVTSFLVTSAVFFGIATAASTSSAIETSTLVGLIATGTLPTTISSNVVMTRQAKGDVAATMVEVTLGNFLGPFLSPLLLTKLYLPAVSAFQDWIPADASNNLPALYRSVMKQMGLSVFVPLAVGQVIRAIWPKQVQKCVEVLRLPKLGSLCLLALIWATFCNAFASHSLETINTPSIVFNVFVNLALCITFTAFSFFLARPPLFAERWSPLLFRRMSREETTSVCFCAPAKTQALGIPLITAMYTTSDDMTRALIQVPMILYTAEQIVVGQVLVYLFRRWERNMRAKEEQEKQTDPGEASVESMEMAETDEQKDDELYITNNASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXQ7</accession>
    <name>A0A1Y2AXQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">BCR39DRAFT_538468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXQ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2AXQ7"/>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY27358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="661" mass="72492" checksum="3467EAE39451165A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXZ6</accession>
    <name>A0A1Y2AXZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_538350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXZ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AXZ6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013299497" evidence="1">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="123" mass="13199" checksum="7F9377D7AE39FAD7" modified="2017-08-30" version="1">MKFVSTIILLATLFGLATTVQGQTAQFFDDSKCSVNGSAPLNFFLGTGCLSNQGGRGSVFFSGPVGETTPYCGITTSNDQRCSCRSKVQKFVPTGFCYQLNRKDKSYEIEPADLQGNCPAPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY35</accession>
    <name>A0A1Y2AY35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">And other transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_565784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY35"/>
    <dbReference type="STRING" id="71784.A0A1Y2AY35"/>
    <dbReference type="InParanoid" id="A0A1Y2AY35"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="146"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="664" mass="73255" checksum="766978E62F09AA07" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYF9</accession>
    <name>A0A1Y2AYF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_222064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYF9"/>
    <dbReference type="InParanoid" id="A0A1Y2AYF9"/>
    <dbReference type="OrthoDB" id="2596102at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="40740" checksum="EE91541D9F0012D6" modified="2017-08-30" version="1">MSKPTDPPPYSSTPAQGSGGILSDSSHHIALQIPDQTYHPGSTVQVKLSVPRSDVNTVDGDVACSLEGYSSVGLMGKSRYQAAQIANAGMGAGGAYAVTAHEDHVFARSSNTIPMTLDKSHAEMGGEQVQFENGLVVPTVRTCDCPGPKENGILPSVPETDMPDRSSVVWKVKVVIKRKGLLKRDIHLSVIISMDLPPNPPLQNPLSFTASRPLSFSNNTLSSPPQLTAELVILRPTKPLTIPFRILLSTTPSPSILSIDDIPPRGDLEVSFSLSRHVWTSGIENSKFNDKGGFQWVGTRVGTLGKGTGNTPGRIGLVQGEKGGEKSRGVLEFEGEYEYLPGQKTVQGCGLAITWSAHVHAQWNKMQSPLSINAPIQLPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ20</accession>
    <name>A0A1Y2AZ20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative hexose transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_539280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ20"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ20"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY27105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="548" mass="59919" checksum="7C1E4EE89E3091E5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZL5</accession>
    <name>A0A1Y2AZL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_213001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZL5"/>
    <dbReference type="InParanoid" id="A0A1Y2AZL5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="389" mass="43549" checksum="D2AA998229B5B144" modified="2017-08-30" version="1">MYAPLDELNFTDYLVQRTLTGELDSACRPGTGEDSVDSLRCVGKGTKKPSIWSAPFTQFWSRASAPESTQVGGSKSSDAATISYPVSPFETQNATSLGLSVVGSDQEETSHTVSSTGVVPSSTMKHGSRPHGTFWQRVVSAAGETSNDTIAPSQTYLSLLYTPPERTLSAAALSSDQILLKKTSRFRLHPEQDRENKEVLGPEFHWAWNTQGRSGRMELGIRLQGRYETHEARETRPSYRFEPETRSSVFLPKSEGPERVLLDWRIVDEKTSVYLSLAGYRDSEKYESCDYGLRGMIGEHESMKELKSSWCRKSLLSLVEAMFRDQIKRLNSSRFAMWRLGSDSQFLRRGTAVELRTRSMDTGWLLCGLIFGNRASMGLISKLTEDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0A6</accession>
    <name>A0A1Y2B0A6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_559542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0A6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0A6"/>
    <dbReference type="InParanoid" id="A0A1Y2B0A6"/>
    <dbReference type="OrthoDB" id="15595at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="466" mass="50567" checksum="63151A7A592DEA0A" modified="2017-08-30" version="1">MKSLFRPFPLPLTGKQWFYLCFLQGVSAGFIDAGANFGIAYAMYHSQDVVKMWVFSQNTIAGDLGVTPIIQCAISMLISSTLVHTDLHHHAISPLPFVYPHVYDLPDPRSLFTRRRVMHDADEKPGEGETVPEAQAQAPYERNFKYYYWMLVRFIFEGTEKNMMLARIPISHWFGRLVWTGAQGAALGIVFGFPIWCLAIVILGPIYGNGNMGNKWAPQVIKLVYGAIVGWITNPVIAVLALGSQAEKHLMVIEVGEDEEAQIGGVETIQEDEEYLPPPPPTSPLRATSFVPSSPSRSTRLGIPSTPTRTRTHSGSIGSYSGRPPLTANVSSFAPPPPLVSPGMPSTTRSRSSTVPTRPARPRGATITSTAPSERSFSYTLGGTGGRAKRSRGLSSVSDSARQGDVPPLNLPLPSSSDENAARQGERTAVWDVFGKNQGTPRAPVMGRRQTTGGHPELGQPVGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0F0</accession>
    <name>A0A1Y2B0F0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_588777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0F0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0F0"/>
    <dbReference type="InParanoid" id="A0A1Y2B0F0"/>
    <dbReference type="OrthoDB" id="10675378at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="406" mass="43815" checksum="F37692B2EFCC03A3" modified="2017-08-30" version="1">MTDDKALTPESLAFSASLFTSQIDSWIPQDFGTKRTESQRAAEFDKAMRAAASMGGENDKRGLGHPELLSASSAGSSGLMALDKRLRKGNQRAASASRMDAERKLGAQEVSEKEQDEEEEEEEEEESRSRMVGKSKRRTTVDLLASKKKAKSQLQAASTKPQPQPLLDTQASSLAQESLSDTQASSLAQESLSDTQASSLRQASSLEQVSPGPEPGPPRPSQSQPQLKDPHSPVEADNPQTPETRTTSSPGGSGDFPFPGPVALDSPRAKQILATKKTALHTIPKSISHTLHESASNTPSESTSHTLNESTSHSSTHKEFPPHSESTPTLDTHDSSLLQSSEEPQTSHSQGTSKQEQKQFLDSDIEKTGGENTGDKGDIIVQSMTKTQRRRDKRRLAKQANITVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Y1</accession>
    <name>A0A1Y2B0Y1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2231 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_559641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Y1"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Y1"/>
    <dbReference type="OrthoDB" id="2580011at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019251">
        <property type="entry name" value="DUF2231_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09990">
        <property type="entry name" value="DUF2231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2231" evidence="2">
        <location>
            <begin position="54"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="236" mass="25126" checksum="ECF3E012DF54A699" modified="2017-08-30" version="1">MLTIACSSAERKDIPAADMSPTTRAAEAAEQAAHQTSQVLQGRIPNQTPDKALGHPIHPSTVHWPIAFLSASFGIVSLNLVPSAIISPLSKILPPLSTLPALAHYAAAAGVLTAIPSIVTGLGEGYEMFRAQVDSKGDWRTVVSDAWNMVDDGGRKLHMTAKHASMNDAVVLLAAANWFHGYKYPTQALPLINTILSAISLPALLYSAMIGGRLVYEYAVGVQRQGHGLEVKEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B119</accession>
    <name>A0A1Y2B119_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_468992</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B119"/>
    <dbReference type="FunCoup" id="A0A1Y2B119">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B119"/>
    <dbReference type="InParanoid" id="A0A1Y2B119"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="15">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY27775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="425" mass="45942" checksum="7DA95A940CE84C32" modified="2017-08-30" version="1">MARGLATPTNINPALLTNVLTPKTPAALHLKSGQSYYGESFGSKESKFGETVFSTSITSYTDSMTDPSYLGQILVFTSPMIGNYGVPSNAPLADTPGIPFLESVKIQCTGVVVSDVALKFSHYQAVESLHQWCERYNVPGLTGVDTRAITSLLRDQGTTLGRLAVGDDAPVVPADVDFWDPSKDNLIAQVSTPHKYTLNPNGAGPRIAVLDFGSKANILRSLVKRDAVVTVLPWDYDFNTIRDQFDGLFLSNGPGDPKAIMDTVMRVRQTINEWNKPIFGICMGHQILGLAAGLEAYRMTFGNRGHNQPVLALASSGSIKAGRVYVTSQNHQYALRLTEDFPSGWAPFFINCNDSSVEGIISTPESGKRIWGVQFHPESAGGPLDTIEMFTDFVNECQAGRRGWKASAMIADEVKIGGSAAKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1P9</accession>
    <name>A0A1Y2B1P9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_468223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1P9"/>
    <dbReference type="InParanoid" id="A0A1Y2B1P9"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="443" mass="49957" checksum="4F5B49CBB30B89A2" modified="2017-08-30" version="1">MSALISQWRHGSIRAGNVSKPKLVVAHFMLGNTYPFTENDWKTTFDQAEETGLDALALNLGPEDWQFNQARSAYSLLTSSPRKLKLFFSLDMNVLPSSSEEEAYDLIDKIAPMISSSASLLWSDSGRPILSTFGGHDRTFGGLGWSKFLQALNHRLGKKVLFIPSFFMPPNDFLSLPFVDGTFAWNNAWPMSNSPTSLDEDRPFLHSDKPYMAAVSPVFFTHYGTSGPFAFNKNWIYRSDDLLYPTRWDHLLSLPVAERPAIIQVVSWNDHGESHAIAPVLGAQPGSDRWTDGMNHDAFMEMTRYFSQKWKGLPQTVVEEGQVKVWMWYRLHPSSMIIDIIDQDEVGRPGNADWAQDLINLMILVPAGSDAKLHLRNGRERHTRVLKPGDANLLTIPFVPGEVQFEVISSGGEQILAGEGKQILKDADRYNFNMWTGSWSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2Q4</accession>
    <name>A0A1Y2B2Q4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_559173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2Q4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2Q4"/>
    <dbReference type="InParanoid" id="A0A1Y2B2Q4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012372662" evidence="2">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="284" mass="26633" checksum="80865BE4519DD3A3" modified="2017-08-30" version="1" fragment="single">MKIPTSPLLFTLALSTTSLAAPISSSGRHDLSPTPDHGDFEPRSPSVNSPLLGGHSRGDDGWGMRPSQMPGKLGRRWGMKRQIPNVQQFPVPVQGLSNAAAGATQGQVNVNGLAPGGLLNEPNGLTAGTPIGGIVNAAGGVIAGTPVGGVINTAGGLTSGTPLGGIVNAAGGVAAGTPLGGIVNTAGGLVSGTPLGGIVNTAGGVVAGAPLGGIVGGLQSGNPLGGVVGTVGGLVSGTPLGGVVNTVGGLTSGTPLGGIVGGLTSGNPAGAISGSSGLFGSIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2S8</accession>
    <name>A0A1Y2B2S8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_533918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2S8"/>
    <dbReference type="InParanoid" id="A0A1Y2B2S8"/>
    <dbReference type="OrthoDB" id="2560792at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="151" mass="15373" checksum="C1613A2BCC7E3E81" modified="2017-08-30" version="1">MSLSGSTGEDYNKTGDGQLHYDEPTGPDPTPENPGGVFPQTGTVSADAGSMPGSGAPDHGGDVRGVFGNPQVFSDTFGHLSGEFSTAINAVKGESGSGLGSVAKALIERLEAMRDEIDGWRKGEGLAGAAEGEKNDEVERAEGDGGGLYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B409</accession>
    <name>A0A1Y2B409_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_171859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B409"/>
    <dbReference type="STRING" id="71784.A0A1Y2B409"/>
    <dbReference type="InParanoid" id="A0A1Y2B409"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="186"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="364" mass="41308" checksum="FF989E69639D04BE" modified="2017-08-30" version="1">MADNSTGLTPQQQALEDAARTLFESNPGLNFGPWIMGFAFDFVLFGVMCHQLVLWLSYGHKERLFVKVLLVWAVIAATATSCFGIALMFRLFVYGFGHYANFITLDWWGWYTIFDPIVVCPVQLFYAERAYRLNDNKIWIPIIIVTLTVVSAAGDIAAKVVTSKSSLSGITTIRPYFYVWFVCMLVGDLFLTVMMVLGLRRSRTGWSNTDRLVNRLMRLSVETQLPCTLVEIAILINWSVKPDSYITFFWELFHNKTHVCAFLAVLNTQFTLRDAFESSGDTSDHKSNNYALGSARKQQATVDLDGIKVDTTIYTESQQIPTLPIGLNRQNLSDDSDMESDRTHVRWDAESQHQLAKRSDVESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4L1</accession>
    <name>A0A1Y2B4L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_574722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4L1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4L1"/>
    <dbReference type="InParanoid" id="A0A1Y2B4L1"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="7">
        <location>
            <begin position="86"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="316" mass="35314" checksum="920D48B9C871D7E6" modified="2017-08-30" version="1">MRNLNRNLELIDKSIRNIRHLSLGSPTTTTTTTSSSSCSLGGISSNHSLPPIRYKIFPRPIPYLVGLRLQDGIIERRLRDKRDGKGGKSDVLLLLEHTPTYTTGRRDSSPNPTTLHPEEKKGGQVTYHGPGQLVGYPILDLNVMETPTRCYVEYLQALLADYVRDQGVKEVLAPHPEGHVGVFTSPTEKIASIGIHLRHRITSHGFAMNITPEPIKWFDLVTACGLTDVHAVCLQDLLPQSGNTLNVKNVARDMVPRFQDVFGREFVELSEEEIHTKEGEVEEDVRAIRELCAEAEKESEGTTHWPSEPDLTKRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4S1</accession>
    <name>A0A1Y2B4S1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_588323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4S1"/>
    <dbReference type="InParanoid" id="A0A1Y2B4S1"/>
    <dbReference type="OrthoDB" id="2563164at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011011818" evidence="1">
        <location>
            <begin position="18"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="529" mass="55993" checksum="B4EA8AD2828F218B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B601</accession>
    <name>A0A1Y2B601_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_530320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B601"/>
    <dbReference type="STRING" id="71784.A0A1Y2B601"/>
    <dbReference type="InParanoid" id="A0A1Y2B601"/>
    <dbReference type="OrthoDB" id="2586076at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="790" mass="86170" checksum="3DAE7E9DA587EF7A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6B1</accession>
    <name>A0A1Y2B6B1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_529513</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6B1"/>
    <dbReference type="FunCoup" id="A0A1Y2B6B1">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6B1"/>
    <dbReference type="InParanoid" id="A0A1Y2B6B1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="245"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="502"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY30378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="575" mass="63748" checksum="54B570A17E153123" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6E0</accession>
    <name>A0A1Y2B6E0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_505464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6E0"/>
    <dbReference type="InParanoid" id="A0A1Y2B6E0"/>
    <dbReference type="OrthoDB" id="2507344at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012169234" description="Helicase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="245" mass="26331" checksum="39D23123D8BAACCC" modified="2017-08-30" version="1">MTAGLVRLSICCSIMLASKTSPALVYTGQLNSDDQQSVLTAFTSITNTPSRVIIATSALGLGVDFPLVMGVIYVGSPDHIIALDQGMGRSGRGTRKGVTLIFPIQRDSQEVETDNMFGQMEMRQMVRDRSISLAGMWPMDNRSTRLLQSLVTVGGHFLLGRSLGKWRLITTALAWVVDLNIGNPSLVICLLHLEETTRSLMWLIETAAGEGILGDAVAGGNGGTPTCTLLLDDKSLHKSVADPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6G2</accession>
    <name>A0A1Y2B6G2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_588270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6G2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6G2"/>
    <dbReference type="InParanoid" id="A0A1Y2B6G2"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR BYE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="8">
        <location>
            <begin position="159"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="616"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="783" mass="84806" checksum="324FD51107B5C798" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6P1</accession>
    <name>A0A1Y2B6P1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_530975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6P1"/>
    <dbReference type="InParanoid" id="A0A1Y2B6P1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="256" mass="27841" checksum="63B718BED727903F" modified="2017-08-30" version="1">MDWFLAHMPWCWCLSSREEQTERDPLLPQFPPPDTILTPPRPHGQLPSPIHTGVYGPYSAPMSPSTGRPDFSRTSSSPGTDRSALERRARREALERDFSGRMRGSGFTQTQPPTPNTADSSNASSPSTSTRPRSSASRLLPRSVSDPDTTRTYADNQRSASSSRIVIPRGRGRRRSASVYQGVMSPILSVGFEGEEGMTGRLGRSRSVGGQPGLTSEAAVEEDVTRLSLGLRGMGSTRKGRSRGRSVVKTPRQVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6S8</accession>
    <name>A0A1Y2B6S8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRAM/LAG1/CLN8 homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_455395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6S8"/>
    <dbReference type="FunCoup" id="A0A1Y2B6S8">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6S8"/>
    <dbReference type="InParanoid" id="A0A1Y2B6S8"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012327479" evidence="7">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY30386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="190" mass="21392" checksum="AB7E9A645716115D" modified="2017-08-30" version="1" fragment="single">MSHALIIIPLAMHCLNSPIIADDPVFGYDPTVARVGAVSCGYFIWDTVDSSLNSTAGFVLHAVCCVAVFLFSFRPFLAGFGPPFLLWELSTPFLNIHWFMDKLALSQSHPTLYLANALVFMLVFFLARIVYGGYQSFLVIQVMWQKRHEIPLHLHLIYTLGNLSLNALNWLWFSKMVKKMIARVAGEAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B838</accession>
    <name>A0A1Y2B838_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_455343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY30992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B838"/>
    <dbReference type="InParanoid" id="A0A1Y2B838"/>
    <dbReference type="OrthoDB" id="2520628at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="236" mass="25129" checksum="375D26FBBCBA5B52" modified="2017-08-30" version="1" fragment="single">VIHAARVTTVWAGLTKGKDRRDVGLLQDLFGYLTMAWGGGTLVSLLLHQPPSWLLSPTPWLIYPTAYLLLVPTRLSEYIVTTAPSLPYNLVGAYIDGMTRGVTITSLPEALSLSGVKGTSWFTPIILSGLAVSGGGWAVQLLGMHEKEWGMGVPGVLRGGILNTLDFWGGMLVGIVYAALMRTHPEFSALSDFTASVLPDDLQVKGTKALVTPETARAICVLLLGSLLAARAITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8E1</accession>
    <name>A0A1Y2B8E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_593571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8E1"/>
    <dbReference type="InParanoid" id="A0A1Y2B8E1"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="424"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="524" mass="56406" checksum="2BE6C210ADE612DF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8M7</accession>
    <name>A0A1Y2B8M7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_528073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8M7"/>
    <dbReference type="FunCoup" id="A0A1Y2B8M7">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8M7"/>
    <dbReference type="InParanoid" id="A0A1Y2B8M7"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="118"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="329" mass="35924" checksum="85C440E7DDA829C3" modified="2017-08-30" version="1">MSKPKVLVVGTILWAKKELQQLSSIATVISPDFSSREGFLKDVSQNHTDAFALLVTNGSKAGAFDRSVLGSLPKGLKYICCNGAGYDWIDVNAAFERGISVSHTPGAVDHGTATTALYLLLAAYRQFSYAEKNAREGRFLQDFPLAHDPEGKTIGIVGMGGIGKALARRVLPLGMKIIYHNRKPVSPEPDFPAEYKSSLDELLAEADVVSIHIPLNEYTKNSFGSAQFDKMKQGSVLINTARGGVIDQEALIKALESGKLYSAGLDVFPNEPEIDERLRKNDKITILPHVGTHTLESRYGMEMVVINNIRSAINDGQLLNQVPEQKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8R3</accession>
    <name>A0A1Y2B8R3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_526892</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8R3"/>
    <dbReference type="FunCoup" id="A0A1Y2B8R3">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8R3"/>
    <dbReference type="InParanoid" id="A0A1Y2B8R3"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="804"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="904"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="914"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="960"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY31209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1026" mass="114279" checksum="8530132F0404290A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8X8</accession>
    <name>A0A1Y2B8X8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8X8"/>
    <dbReference type="FunCoup" id="A0A1Y2B8X8">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8X8"/>
    <dbReference type="InParanoid" id="A0A1Y2B8X8"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34453" checksum="5DB59BED3CD81848" modified="2017-08-30" version="1">MSQPGYAIVDVDEEVCESLPRLAVVLIVRSLLHLTPYDSFPRRSVGERYDGSSFQQFGVQKYEYRDTFLTTDPAPQRPHSPGSRRDAPDVPFSPFNLAYYQSYFDVDTSTVFKRVGLAMIPRDGFIAEVCDGQIDLYGPFWTLTTLILFLYTTSTLTASITQYLSAPDSHASSNLPLLSTAFSVVYIYGLLVPTLLWGATKWLGVGEWGAAEALGLYGYAMGIFVPVSILCLIPVGILRWVLVGASAFSSGYFLIRNIYSVLASADNNMSRLLIIIVGVLHAAMALAMKVLFFSYAVAGVIVGPDPIGNPIGNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAI4</accession>
    <name>A0A1Y2BAI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beach-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_525741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BAI4">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAI4"/>
    <dbReference type="InParanoid" id="A0A1Y2BAI4"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="1628"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="1777"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1363"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1578"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1363"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1382"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1588"/>
            <end position="1600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2329" mass="257109" checksum="E92D2C0501CE6DFB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAP8</accession>
    <name>A0A1Y2BAP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_69087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAP8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAP8"/>
    <dbReference type="InParanoid" id="A0A1Y2BAP8"/>
    <dbReference type="OrthoDB" id="2573612at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="285" mass="31904" checksum="ECB7D7E9EA39D5F3" modified="2017-08-30" version="1">MPCRCRGQIGTTLADLKLLIDEVDNPQGRLQVCVDLNHVYTAQVDFTTPAGLEILIAAIDHVGIHNITAFHLSDSGYQHGSAGDAHVDFGRGYIGIDAYRRLLRHPIFSQVPTIFEVPPYCTTFRQSTLKGTTIPENLRKLDDLNQELFELIIQMSDRSWEEYGKRVIKHYYFVEIRIRQRIRQAAIKLGDAAYQAFQEDRQQTSNRNRAIARGKETGGVKKRKARDSGLLSGLGIIPKDVCNTPRQTTRGGKKYGAEESEGTYESDSINDSGSLDESESDGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBD2</accession>
    <name>A0A1Y2BBD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBD2"/>
    <dbReference type="InParanoid" id="A0A1Y2BBD2"/>
    <dbReference type="OrthoDB" id="3366352at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26509" checksum="F90912E5D248A1FA" modified="2017-08-30" version="1">MSDGAEGMKVPEPSRQECNGTIPTINFYAHMSYLTARSALLRRVLATPNPVDPKGVKFLPTDRESHLNLWIPVPDTRSFALLLHWIYWGDEKALDVGLKDGTANWKGLVANVQYLEMDSETKFAVGIWWKKWVKTGVGRDGEVIDRGLRRTPRGENDDEDDDEDDDDDEEEEKEEDDGGIKGRTRGQGEEEGLVRSKDVEMEQPSMVGGLGSDGGTGSGSDGTRTREGEDEVVGLLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBW2</accession>
    <name>A0A1Y2BBW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Family 2 glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_524019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBW2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBW2"/>
    <dbReference type="InParanoid" id="A0A1Y2BBW2"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="6">
        <location>
            <begin position="100"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="218"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="5">
        <location>
            <begin position="343"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY32328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="654" mass="72889" checksum="B8E4A6383E054BB0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCG0</accession>
    <name>A0A1Y2BCG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PQ loop repeat-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_492505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCG0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCG0"/>
    <dbReference type="InParanoid" id="A0A1Y2BCG0"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY32521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32510" checksum="B23807418B1B3949" modified="2017-08-30" version="1">MLDSSVTFWEIFVNTCGVLYFLAWSASFYPTLILNYKRKRTTGLSPDFVWINPLGFLALTLWSWGVYFSPIARNQYRARHDGHEPQVSRSDLAFSLHALILSCITPAQVWYYNRHPSPNQQSTQDDERTALLPSTPATKTDDALSPPGGIKPSVPCQIALAVMVVASFIYAIFVWVGKAEFLDWLYFAASIKLAITCVKFIPQIMLNWKLRSSAGWAIDQIFCDLAGGILSLTELIVSSIFIEHDPSGIVANPGKLGLAAVSMCYDTVFILQKYWFFPETGEIKLDSEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDJ0</accession>
    <name>A0A1Y2BDJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_522307</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDJ0"/>
    <dbReference type="FunCoup" id="A0A1Y2BDJ0">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDJ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BDJ0"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY32891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="462" mass="52067" checksum="678E52DB61069291" modified="2017-08-30" version="1">MPPIRPPDSSSPSSRGPNAARQLVSLVKALCFDRRYYWHVVSLLFLGELFLGLLIIHKVPYTKIDWPAYMQQVEAFLDGERDYSRIEGETGPLVYPALHLYIYTALHSLPYANRVRAAQYIFLGMYLLTFLLVATIYFHSKRIPQILLVPLTLSKRAHSIYLLRLFNDPLAMVLLYAAVLSLMYGRWRLGSVVYSLALGVKMNILLFLPGLLVLSFQHRGLIKTLQNLTIITIIQLLLPSPYFVSFANSYLTKSYFSSAFDLSRQFLYEWTVNWRFVPSSTFLSREFALGLLGSHVGLLIIFAWFKWSPIPGGTITVLRRGLLQSWTNPPVPQHTLPSHHISLVLFTSNLIGMTCARSLHYQFHAWYFHQIPLLLWFGGAWGSASLGAALWLSTQYAWATAPSTLLSSGLLLGTHLIILLGLLFHNQATRPKIIPNPSPIPSPTPAPTPAAPIPIPETKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDX3</accession>
    <name>A0A1Y2BDX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation initiation factor 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_520792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDX3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDX3"/>
    <dbReference type="InParanoid" id="A0A1Y2BDX3"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36973" checksum="520FCB77C95CDEA7" modified="2017-08-30" version="1">MGSIGPTCLTRQAARRLSLASSSTLVTPSSSRTSNRFFHNPSGSGPSRASQPSSFVLRSGPRPVGSTPSYGNRPQQPQRVGPSTPKHNPIRTAIRQAEDDSTDPKYVTNHDIPYRTVQVASTSGPLSSPRHLNDILSSTDLNKFVIRLVSEDPPVVRLFDKELLASKEKEYQAAQTARKRFQSDTRIVTISWACADGDLNHKIQQARRHLLDGDRVELVFAVKGAAHKDKTPQSRKDEIVKSFMDGIQDIGIRGRDDLVKGKGLSSFWNPKNEIRNAAITELKDTLTEQQKGKEERAERRRLKAEERRIKAEEERIKAEKRFKQVMDGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE56</accession>
    <name>A0A1Y2BE56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_521890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE56"/>
    <dbReference type="FunCoup" id="A0A1Y2BE56">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE56"/>
    <dbReference type="InParanoid" id="A0A1Y2BE56"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="389" mass="42217" checksum="4779CE1AC83C6FBF" modified="2017-08-30" version="1">MLLTTLTLYIRKSSCISTISRRVSSIPRRMTSTSLPFSKYAPETELAVLAVLRACYLTKSVQDTLVPKDTLTKPDKSPVTVADLSAQALISLHLQSHFGEDKIVGEEDTTELRANDPLRAKVVSLVNEGFGREEGWGRGHIWEESEVLNAIDAGSSEGGKIKRFWTIDPVDGTSGFIRHQQYAVCLALIIDGQVELGVIGCPNLGPEPARLGEEIMPNGKGVLMVAVRGEGSWSRPLSEPTYTRLHLPPSPTDASTLTFLESVEAGHSAHTIQARIGEILQVQRPSLRMDSQAKYACLARGEGGVYLRIPTKYSGGKDYQEKIWDHASGDLLIAESGGICTDMHGRPLDFAQGRTLRANEGIIAAGRDVHARALVAVREAVEGIDGQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEU2</accession>
    <name>A0A1Y2BEU2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phospholipid methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_463700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEU2"/>
    <dbReference type="FunCoup" id="A0A1Y2BEU2">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEU2"/>
    <dbReference type="InParanoid" id="A0A1Y2BEU2"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY33351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="606" mass="68079" checksum="A291298FF5E0038E" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEZ1</accession>
    <name>A0A1Y2BEZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative dipeptidyl-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_582241</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEZ1"/>
    <dbReference type="FunCoup" id="A0A1Y2BEZ1">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEZ1"/>
    <dbReference type="InParanoid" id="A0A1Y2BEZ1"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="16">
        <location>
            <begin position="170"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="15">
        <location>
            <begin position="640"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="848" mass="95407" checksum="314A1AE84D363F41" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFK1</accession>
    <name>A0A1Y2BFK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen debranching enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_520445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFK1"/>
    <dbReference type="InParanoid" id="A0A1Y2BFK1"/>
    <dbReference type="OrthoDB" id="2591256at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013141536" description="Glycogen debranching enzyme" evidence="1">
        <location>
            <begin position="20"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="82954" checksum="8FC41E11938CB798" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFV0</accession>
    <name>A0A1Y2BFV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_563906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFV0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFV0"/>
    <dbReference type="InParanoid" id="A0A1Y2BFV0"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="45"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="529" mass="56247" checksum="61AE8A4517D14414" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFY9</accession>
    <name>A0A1Y2BFY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="29" type="ORF">BCR39DRAFT_491478</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BFY9">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFY9"/>
    <dbReference type="InParanoid" id="A0A1Y2BFY9"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 21 22" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16 21 22" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="13 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 21 22" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 21 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="17 21 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14 21" id="KW-0521">NADP</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 21 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 21 22" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="25">
        <location>
            <begin position="78"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="28">
        <location>
            <begin position="191"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="23">
        <location>
            <begin position="416"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="26">
        <location>
            <begin position="1332"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="24">
        <location>
            <begin position="1455"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="27">
        <location>
            <begin position="1579"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="21">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase" evidence="21">
        <location>
            <begin position="1327"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="active site" description="For EPSP synthase activity" evidence="21">
        <location>
            <position position="844"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1216"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="895"/>
            <end position="902"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="ORY33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1615" mass="173842" checksum="32FB57987B4641EE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGA1</accession>
    <name>A0A1Y2BGA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGA1"/>
    <dbReference type="InParanoid" id="A0A1Y2BGA1"/>
    <dbReference type="OrthoDB" id="2017695at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="211" mass="21704" checksum="65B01A98B21237F7" modified="2017-08-30" version="1">MSDIPPKPITPAAALGEPPAKALDPIAGEPSLFDKAASLAKPYLDKVDQTTRPYVEKVQEATKPYTDAATAKAKEVIDKIEGHPAPSTTGPEGVTTTTETRELSSEGGATSTSGFSAGNVQAQALGVLGQIQGAFNTLTHTIDEKTASPTHPGIISQVTAAVQKGVEKVDSLLDQPVTPAAPGSQHPILTTTNSVPHVQGAEDPAVSDLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHH7</accession>
    <name>A0A1Y2BHH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BCR39DRAFT_517187</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHH7"/>
    <dbReference type="FunCoup" id="A0A1Y2BHH7">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHH7"/>
    <dbReference type="InParanoid" id="A0A1Y2BHH7"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ORY34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="371" mass="42806" checksum="FBAB5FA748AFE444" modified="2017-08-30" version="1">MSHKKDRIYALADVAKHTSRSSCYVTYRGNVFDVTSFLPDHPGGDDIMLEYAGKDIGQVMSDESVHVHSKSAFEMMDEYKVGELGGDERIVSEDWVADVDFHPDETDTLADFNRSKFLDLSKPLLAQVWSAPWTKEYYLSQVHNPRHLKESARLFGSDFLEGFTRCKWYVVPMIWGPITAFLFVLSLLQFTDSSMTANKLLSFPIPAVPIPTTLAFAKLSVCYALGVVIWTILEYTLHRFLFHIDYYLPERNWAYTLHFLGHGVHHYLPMDRLRLVMPPTLFFILETPFTNLAHLIFPKAIANGIIAGSFSMYMVYDCMHYALHHTRLPQYMAEMKKYHLAHHYKNFELGFGVTSKVWDYVFNTLLPITSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIN1</accession>
    <name>A0A1Y2BIN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_513803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIN1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIN1"/>
    <dbReference type="InParanoid" id="A0A1Y2BIN1"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="272" mass="30096" checksum="2EB4613C7C1A6DAE" modified="2017-08-30" version="1">MVRPTSLLSIARTLPRTIPQRQRLSLSLSPSPLVTLGRTLHTSPFRSFATPTTGPQRVTSGPPPPASSEATANANAVKDASSPGSRSPGETTPGSASQLADSSYPDYSKGPSALDKASQLFFFTEILRGMWIVLENFFRPPYTIMYPFEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIESEAREDGSRRTTKYDIDMTKCIYCGFCQEACPVDAIVETQNAEYSTETREELLYNKEKLLSNGDRAEAEIQANLQADHFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIT5</accession>
    <name>A0A1Y2BIT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_586202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIT5"/>
    <dbReference type="InParanoid" id="A0A1Y2BIT5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013028181" evidence="1">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="231" mass="26136" checksum="E41569A95778DC33" modified="2017-08-30" version="1">MLFSFLSYLSLVLYSFSAVTPHKMTTIPYQTSPLDPSHVEQVPVFELYARRATNEYEGGITPTMIATHHAGDLVSFQDLESRINKPNTRIEIERVSGIEEIRLIDESTGKYNSAKGDIAKSIIDEWDAREAVFFADPDRLPDGSSELGEVHHKSIVQYDDGGYRILPAFRKKGEVHSKEEFWGKHGDYSYLWAAKGAAAVVDTRTGEFWVATADVAKEMDEDMRNKRPRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIU5</accession>
    <name>A0A1Y2BIU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CPSF A subunit region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_572835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BIU5">
        <property type="interactions" value="711"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIU5"/>
    <dbReference type="InParanoid" id="A0A1Y2BIU5"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="21"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="376"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="555"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="920"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1293" mass="138499" checksum="501328D69F61A712" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ08</accession>
    <name>A0A1Y2BJ08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_596661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ08"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ08"/>
    <dbReference type="OrthoDB" id="2564232at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32459" checksum="7B2DB69A54B8B0A8" modified="2017-08-30" version="1">MQVAQESTYVRVFDPATDAKEVRMLIGQGVMEGLAHANRKVLTYPLSLTVWVGLAAVFNYATGLVPKSGEPLTYLSPLIGFAAVALPLMFIPEYLHRPIFTRLMRETLGAPDVVALPKFYALDERSKIIVLEHEKEVQGVVCLDGRRAGEDLGTVLGAEEGDLGDKGVIESAGVGTQKGGRKTVATLGANPGVVEIRHLDVDIPLRQAGVTMELLAAALDHAFCVKPFSNAKFSPTTKVIYRTNPFVTDEEAFRRCGFVTSAGPWSEAIGVGLFNWKGRWLEVTPAVWDAKRSNVYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ48</accession>
    <name>A0A1Y2BJ48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_585760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ48"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ48"/>
    <dbReference type="OrthoDB" id="2564755at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="294" mass="33288" checksum="C0AECC1F505AFF53" modified="2017-08-30" version="1">MPDPAVDAARLGLPYTEPNSRSHSRKKSQKVRFEMIVDPSDPSAPPRPRRVLEKKSGSGFGLLDRIRWGNEPDLPTTRPIGTSGRPLPQLGATTNKHFAAQGLAAHDPTPSALPPNLEAHIVPHSFPPDFAYLPRNEKRYLERMHREELRGIKAIHEGTRMAEKAKKEEMKWLEKEKKRREKEEEKRLKREEKWHRKHPFRSLPIPSKPGPATPTAAPPPATVQPTGWMMLPTHEEFGIRRPFDSPGRPAGLGGPVRAPEWPMMSRTMSHAITDMAREERVHLVNGGRLWTPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ89</accession>
    <name>A0A1Y2BJ89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_515096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ89"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ89">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ89"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ89"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="431" mass="49826" checksum="B63037DC2EDA7BD9" modified="2017-08-30" version="1">MPIPIRDDPMVDHDPANPQVMSAFYRRLFPYRPFFLWLNQDHVPAKLYTHREFAFTLQGDVYIRYNSFHTSDDFKKEVLRLNPSRFEIGPQYSARPRDRKTLAAGALQPQRRELVFDIDMTDYDEIRTCCSDKKICKRCWGFIAAAVKVLDHALRETFGFKHLLWVYSGRRGIHCWISDQHALDLNDDQRKALVTFLEVIKGSKEQSKKVNVRGAKDDADLHPALKDGLDQLKVDFVKLILRDQDCFRSERGWEALLAILPADRDVIGPLRSKWQSSPTASSEERWADLVDAVKVLRKGNTTLFRKYERAMEDVILQYTYPRIDAEVSKHRNHLLKAPFCVHPGTGRVCVPVDPSLVDEFDPDTVPTVGELLNELDRIPPEHVEGGTKRRAEDYEQTSLKPYVEMFEEHVAAILKDGRGVKRALKEESMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJD3</accession>
    <name>A0A1Y2BJD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UMP pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_515386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJD3"/>
    <dbReference type="FunCoup" id="A0A1Y2BJD3">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJD3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJD3"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000003">
        <property type="entry name" value="Uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="215" mass="23070" checksum="8284C310FBFC2C8C" modified="2017-08-30" version="1">MSSSNLHVISHPLVTSKLTELRAHDLPAKDFRDGVKSIASMLVFEASRELPLAPVPGLQSPISEFTGYTIPLRIGLSPILRAGIGMTDAALDLFPDATVLHLGLFRDKVSLQAVEYYSKLPTNVTADLVFLLDPLIATGGTAIAALTMLTEWGLSQSQIKVVSVLGSRVGVQNVQNEFPDVQIWIGAVDDELTDRGYIKPGLGDAGDRLFSTGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJJ9</accession>
    <name>A0A1Y2BJJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_138636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJJ9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJJ9"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="312" mass="34163" checksum="26AD892DB87D4963" modified="2017-08-30" version="1">MAESSAKAEDKPASAVLTLQEWLKLLSGRGVDMRVAMTLAAKIYSSHKSKELLGGLTAQKLAPIIPDKDQRRTVLNAVKGIASGQTYVKKRTRDSDLLEPLAAAKEEQATSLEFNEITDPESLIPVTITTNRAPVKTAWAYTVALRMGFDVQEALSIAHVHVHISSLKHALMLGNILNPAETKEAEDELSELPGEIPFVPKANKAKGKGRARGREEVVETAIGSSQPWVGIMRSRPVIERPDGTWRAIQKGLPVEPSVAYLYITRAFKDYTGHVMGSLKLLADSYTGDELNRLGMHMYIAEQTSFSSQVGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJK0</accession>
    <name>A0A1Y2BJK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_462172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJK0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJK0"/>
    <dbReference type="InParanoid" id="A0A1Y2BJK0"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="99"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="224" mass="25335" checksum="BC950993AEC54539" modified="2017-08-30" version="1" fragment="single">MLRLPRLVLSIFLVILFTSLYIFYPSSERTPRAGEVEYSSYEAGGIDSDHYRRPIKPDFDFDREEQGRAWEEDDQEVSSKSGASEDIFMGGVIMPKLGNETAKAELGRAAWRVLHLMTLRYPDNPSPDDRLALKSYMHLFSRLYPCGECATEFQKLLKEYPPQTSSRKSASLWLCHLHNLVNIRLDKPEFDCLTLDETYDCGCGPESSASSTLDVEGAKETGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJP7</accession>
    <name>A0A1Y2BJP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_517878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJP7"/>
    <dbReference type="InParanoid" id="A0A1Y2BJP7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="261" mass="29027" checksum="DC4477D26CFEFFA2" modified="2017-08-30" version="1">MSSSGTNLLEWEWDYPDHEVQMSRLKTGLHQPVEGTTGETSRKLSASMMDVSFNFSGEHPDMHDSDDVKFEATVVFGEILDFSPDLAPDLDGDPAGTFMTGPTVAALATELVRSFVESDHVSSVSILANNAVTWFGDFVRDTDRSKLTASELYSHAETVVSSNEKLKEHPGEWAWKRTTRTAGRGRPDWRSNSYIYTVEHPNSTSPCQRLKIKWENFSVNTTFPEVAEDEDGPLQVERVSDVSDPTDPPHISKPISDITTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJS2</accession>
    <name>A0A1Y2BJS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_515181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJS2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJS2"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="144"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="809"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="821"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="844"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1078"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1199"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1303"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1348"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1484" mass="161570" checksum="39ECC68182B2D48F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJV1</accession>
    <name>A0A1Y2BJV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-dependent hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_573782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJV1"/>
    <dbReference type="FunCoup" id="A0A1Y2BJV1">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BJV1"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="46754" checksum="E6288D60494516E2" modified="2017-08-30" version="1">MCSDHAVTGPSSSAQPDGPPDWESINLPPAHILAHLTDAHCHPTDLTHEQNVYYEVALGGLAAMATVPEDQDKVDYLAGLRPWTTNIPGVSAKQEGKRKGPKVIACFGYHPWFIHRYTLSPSSSIPSKQEHYHSIFLPSNQDVNSKNAQLLDTLLPFLPDPIPFSPLLDQLRSNIRNSLEKGRLCMLGEVGLDGGARLRWPINARHLYVEKYPDDSGENSEEGHEGWKRLTPFKTSMTHQRAIVEAQLEVAIELGVNVSFHSVSAPGPTMDVLIRMRDKHRTRFTNRINVDLHSAGGWRPAFWLQAEKQLLNLYASPSIFITGRSATAAALIRSISPDRILVESDSHEVRWSTGLVWAATEWVARLKGWRLEDGSEMDWELDSDDLQESEDEQQNEWGAVRRIEYNWARFMKLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BK65</accession>
    <name>A0A1Y2BK65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_516069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BK65"/>
    <dbReference type="STRING" id="71784.A0A1Y2BK65"/>
    <dbReference type="InParanoid" id="A0A1Y2BK65"/>
    <dbReference type="OrthoDB" id="2190159at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="186"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="302" mass="34007" checksum="9BCF6E3BDA4ED63C" modified="2017-08-30" version="1">MNLPHDASIPYIPPDHPLQPSPTSLIVDDTPHSSDTTSPTGQTPFTQQHTQGPSSPFPLATIDDQHQITQSQPYQMGQQPTDLGPFITPSNTLEAIPSKGQATGDRFITPASKYQTAPALPDWETAYRDQRRERWGSKVKEDLKGWRGGHGPVRSNYARTTTDLPDTTYFGQPVTGTIGLHLPKEVVRIERDWSGGEVCQFDTTFPIELEDRITPDQWRTFIDQLNIHLAEAYSVKGAVMDNLLAIFTWWTSLLWSTSHFERGLKEAEKTIQQANTEVFESKGLRVLSPRSVALQFLEIEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKM1</accession>
    <name>A0A1Y2BKM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative kynurenine 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_508722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKM1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKM1"/>
    <dbReference type="InParanoid" id="A0A1Y2BKM1"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="416" mass="46121" checksum="C9A7D3CDBFC789EB" modified="2017-08-30" version="1">MAVIPRHVLIVGGGLAGPCLALSLARHNIRSTIFEIRQTRGDGGGSISLGPNALQVLDRYAGVYDQIRAAGFSYHRFGAFTNEGERLGEIAVGEEGKGEDGYPAVRVMRSTLHKVLLDAGEQFGDMITVKYGARLTEIEEDNQRVTAHFEDGSQAQGDILIGADGMHSRVRQHVLGDKAPTPTFDGLCIIYGFVPATLAISPSPDFTFPAFMFTPSGLFMTIPIDSEGMTLAWVINKPMTERNREQWQELERSGEAARLAKADYDSIQTEPVRSLLDNADETRARLWAAYSIPDLPKWHTSRVCLIGDAAHGLPPNGGQGSAFAFEDAAILTRLLKSDNTTSYNQLFARFEAIRRPRIEKFRKTSSRKGGALKSQSGPWVWYMKKWAFRAFFWWNSGVLQHTEETTYDVDQVDIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKR7</accession>
    <name>A0A1Y2BKR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_509147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKR7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKR7"/>
    <dbReference type="InParanoid" id="A0A1Y2BKR7"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45227" checksum="B5ADAED0BC6AECCF" modified="2017-08-30" version="1">MLDPAGFTIVIASAEQEEQHARGQFVPWARGRSWEDFVAIHQQERREGIWSKDKRLLTWVLVKRDALDGEIYAGCETYRRTALVRRKGSEEVEQASTYGIASVVTPVKHLRQGYATHLLRLLHYMIAEPTFLPCFPSTWGNPPPCIPDNMARYVPKAISSILWSDVGSIFYERCTIGESRKGWVVRDDQCFELVWKLHPPPLTDTISESIEELHDVSGIADEMTASHLNKLRDIDIDNCGQSVWTTEPSSTGVMDFIAEKGKYGSQSEERDSSKAEVRGLRYHGSKKDGSDDTVILFTPYNINIGARLLITATLGLEAHPERLEALIGALDKYGIAAKRTEGWIWGLGDDSEVVRRWKSLDGREVRCGRRAEKDGHLLGVAWYGHEGDSADMLDTSMWSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL17</accession>
    <name>A0A1Y2BL17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose and ribitol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_508879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL17"/>
    <dbReference type="STRING" id="71784.A0A1Y2BL17"/>
    <dbReference type="InParanoid" id="A0A1Y2BL17"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32577" checksum="2FF5B6D5218AF3DD" modified="2017-08-30" version="1">MPPPSSVPEQYRPGFLPPSIVEQMQQELPGKQVPLNPAPLDDVLADGTKYKAAGKLEGKNAVITGGDSGIGRAVSILYALEGASILINYHPSEEKDANDTKDYISKVAPSAKVQLAPQDLRDEEGCLKLVEVVKKWSGGKVDVLVNNAATQNQVDDIADLSSEQWRHVFDVNIHAIFYLTKNILPLMPWGGSIINNASINPFVGHPGLLDYTATKGAIVGFTRALSNQIVKEKGVRVNAVCPGPIWTPLVAATMTEESLKSFGPTTAIGRAGQPVECATAFVFLASADSSYFTAQCFHVNGGSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL79</accession>
    <name>A0A1Y2BL79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphopantothenate-cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_563109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL79"/>
    <dbReference type="FunCoup" id="A0A1Y2BL79">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL79"/>
    <dbReference type="InParanoid" id="A0A1Y2BL79"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="38952" checksum="BA796A26099F0ADA" modified="2017-08-30" version="1">MSLGSSVFSTESYFHTQKPPDGLDIKTARMGEFVEHWRGVQGNKVVLVTSGGTTVPLEANTVRFLDNFSAGTRGATSAEYFLSAGYAVIFLHRQHSLRPFSRHYSHSLNPFLDLLSESSGTIAVSPEHTAKLLPILRAYHAAQVKGTLLSIEFQTVNEYLWLLKGVTGVMAPLGRRGMFYLAAAVSDFFLPEDKMAEHKIQSGHGTLSLEMDQVPKVLRPLVQEWTPEGYIVSFKLETEERFLIPKARAALSRYGHQLVIGNDLHRRKYEVVFVERTDGRRKTGVEDIPGGAETPPLEDANEFKETWLRLADLTRRTGNGADGEVEIEELIVNELVNRHDRWIADAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLC7</accession>
    <name>A0A1Y2BLC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_21148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLC7"/>
    <dbReference type="InParanoid" id="A0A1Y2BLC7"/>
    <dbReference type="OrthoDB" id="2554033at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="271" mass="28353" checksum="2AFB8B7E6DDD569D" modified="2017-08-30" version="1">MSSPIPIYSTPPHPSHAGQGQGNMTTPSSTLSISPQTPLSPSQGLATSPSPQTQPGLFKWASSFSKSPTHNPPTTNTPMPLPSPQVFRPEEHEHEAHDSFEFGDMSDLRSRSWSTSRRAVSVSGSSGISSLLKGFGATSASPAVASTPLTAGNNVTQQQSEMSQASVPAPGPGPGVMADKVAKGQGVLRRFSMSGVGFARPPFMSPPNTAAPLPTDTAPTIAPPIEPPTADPTVQRANTVSGARGRRYSETTKKRGVSPMGERILREHGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLF3</accession>
    <name>A0A1Y2BLF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-dependent protein kinase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_511153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLF3"/>
    <dbReference type="FunCoup" id="A0A1Y2BLF3">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLF3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLF3"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20532">
        <property type="entry name" value="CYCLIN_CCNL_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="192"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="339" mass="38582" checksum="BAEB5BDAB314A33F" modified="2017-08-30" version="1">MPAPPHPLATLAQITSTPSSRDGIPPEVEDDLRVAGCMMIQEAGIMLKLPQSTMATAQVIFHRFYYVSSMASFGINDISVSALYLSSKLNETPIRLRDLINTYIFLTARIRHLLKQPADDLFQIMNVAGPSRFGSNGKGKEKERDPVWNGFSFEVPGFHDEVFWDWKDVIVASEMQILKRLGFNMQVDLPYSHVINYLKILDLVFEEGIAQSCWSILNDALLTPLYAIHPPHVLACASILLTTRLHRIPLPAEWYILFDTDSDELWSCCGTIMTLWSTWGLGRPTGSTGAREETRAERKARENRWRRAWILAESRRAVRKWVEEREKETGDAGHPIEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLJ0</accession>
    <name>A0A1Y2BLJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_511306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLJ0"/>
    <dbReference type="FunCoup" id="A0A1Y2BLJ0">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLJ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BLJ0"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="195" mass="22847" checksum="71BE6CD016948A11" modified="2017-08-30" version="1">MVNLSQQKRLAASVAGVGQRKIWLDPQEAAEIAQANSRSGVRKLLKDGHIIIKPTNIHSRARTRDLQAAKRAGRHTGFGKRKGTAEARMPTKVQWLRRMRVLRRLLRKYREGGKIDKHLYHTLYAEIKGNRYKNKRVLMEHIHRAKAEKLRTKHLQDQMEARRVKNKAMRQRKADRLAEKRQGILEVEREDEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLN5</accession>
    <name>A0A1Y2BLN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_511482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLN5"/>
    <dbReference type="FunCoup" id="A0A1Y2BLN5">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLN5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLN5"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="82"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="196" mass="22170" checksum="F293A857B0DFF0ED" modified="2017-08-30" version="1">MNISFSTSAASLAAPNTAMANRPVFDADLMNQSSVYEPGATHELAKQGKYRAPPGKRETVIRKGSGKTWEDPTLLDWDPKWYRLFVGDVSNDVNERTLNEAFSKYPTYCKCKVVKDRLSLKSKYAFIAFKDPEDFLKAWKEMDGKYVGNRPIRLSKVQDDKYGSIATTVVSGKKARELDKLRRNHGKPLDGRPVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMD3</accession>
    <name>A0A1Y2BMD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_568827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMD3"/>
    <dbReference type="InParanoid" id="A0A1Y2BMD3"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="546" mass="60403" checksum="3B1E78244866C020" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE01</accession>
    <name>A0A1Y2AE01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 14">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_554803</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 14"/>
    <dbReference type="EMBL" id="MCFC01000125">
        <property type="protein sequence ID" value="ORY20789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE01"/>
    <dbReference type="FunCoup" id="A0A1Y2AE01">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AE01"/>
    <dbReference type="InParanoid" id="A0A1Y2AE01"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011828692" description="Protein disulfide-isomerase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="336"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="459"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="386"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY20789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="498" mass="54954" checksum="503ED35928F77D57" modified="2017-08-30" version="1">MKVSTLSLFGALTTLVGVFASDVVDLTSGNFKNEVLGEDLALVEFFAPWCGHCKNLAPHYEEAATELKSKKKIKLAKVDCTENQALCGEYGVNGYPTLKVFRNGEPTDYTGPRKADGIISYMVKQSLPAVTDVTPGSHDEFIKSDKVVLVAYGNPTIPIPDAFREYAEIARDSYLFGAYTSSPPPEIPETPGLPAIVLYKSFDEGHAVFRDSDVTVESLTEFVRANSVPLMDEISPENFGAYAEQGLPIAYLFIEPEDTTTLHTLVDALTPVAKELKGKVNFVYIDAVKFIDHGKSLNLPGDSWPAFVVQDLAAQTKYPLTGTVSAKAITEFMNKFIAGEIAPSIKSEPIPEIQEESVYHLVADDWENLFGQDDKDIFAEFFAPWCGHCQRLAPIWETLGDKYKGQNVIIAQMDATLNDVPPVAPFRVAGFPTLKFRPAGTTEFVDYNGDRSLDSLEEFVESNRRSKAPSGNTTAHDDDDDDEDEEEFEEDVPEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE68</accession>
    <name>A0A1Y2AE68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_601430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000123">
        <property type="protein sequence ID" value="ORY20873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE68"/>
    <dbReference type="STRING" id="71784.A0A1Y2AE68"/>
    <dbReference type="InParanoid" id="A0A1Y2AE68"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="7">
        <location>
            <begin position="572"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY20873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1129" mass="126650" checksum="695216CAA101D3ED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEI4</accession>
    <name>A0A1Y2AEI4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_567340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000128">
        <property type="protein sequence ID" value="ORY20677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEI4"/>
    <dbReference type="InParanoid" id="A0A1Y2AEI4"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY20677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="571" mass="63121" checksum="F28205E7454DBEBD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG66</accession>
    <name>A0A1Y2AG66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_553330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000108">
        <property type="protein sequence ID" value="ORY21598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG66"/>
    <dbReference type="FunCoup" id="A0A1Y2AG66">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AG66"/>
    <dbReference type="InParanoid" id="A0A1Y2AG66"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY21598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="939" mass="102675" checksum="41761F79C2BBE6CF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI33</accession>
    <name>A0A1Y2AI33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000101">
        <property type="protein sequence ID" value="ORY21940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI33"/>
    <dbReference type="InParanoid" id="A0A1Y2AI33"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="387" mass="42841" checksum="D8E2998C6A545BC5" modified="2017-08-30" version="1">MKAQIEQKTEASLSSSSSSKINEATDLSDENQGDSSDMVITPQNTGNCILRVNSQLDVMDALRRGIAALASPSPTEDVDPEQYVTGEFSMRQMDDEAQESYIEELEEQLADEVNKVAYTIATQANVISSQADTITVQADDIATLKTAVGTQENIIIKQEATISTQSDQLRSGSARLEEYEDLVLDFLRYVRPPALVGVTNTSEVVGNLCRTVVKAMLSFPTPEGLKRAIEAFDCIKESDKGGTSVRALFHYRVFCDLMAICDSAYDPARDISIILRESLEKLAQHVMKSSKASITRTIRKHTGNMRKEGIQGALSHLVENFGYYRTPEALSQAVLDAAMESFRSAAAVQGSQEQKKWKHPLDIEQVLQEWLDSRHSNRRPMNDHPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI83</accession>
    <name>A0A1Y2AI83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_48834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000102">
        <property type="protein sequence ID" value="ORY21897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI83"/>
    <dbReference type="FunCoup" id="A0A1Y2AI83">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AI83"/>
    <dbReference type="InParanoid" id="A0A1Y2AI83"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY21897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="316" mass="36037" checksum="B41A5A1FC50A69A7" modified="2017-08-30" version="1">MSYGSPEHQEWILDEETGIDHIKYAYEHGINTFDTANTYSGGLSEVCLGKAIKAIGCPRESVVILTKVFFPVVPPSEKGKKDDFINRKGLSRKHIFDSVQASLKRLDMEYIDVLQCHRFDPDTPIAETMQALHDVVQKGWVRYVGMSSCWAYQFHAMQNYAINNKLTPFISMQNFHNAAYREEEREMVPTLKMFGIGMIPWSPLCRGFLARPWKAEETLRVKTDSTYKQRGHDKPDEARREINERVEEVAKKKGCTMAQVGVAWSLSNDFITAPIVGSTKKERLQELIDAVNITLTPEEKEFISEAYSAQHVLGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIM4</accession>
    <name>A0A1Y2AIM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_508148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000095">
        <property type="protein sequence ID" value="ORY22322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIM4"/>
    <dbReference type="InParanoid" id="A0A1Y2AIM4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="203" mass="21844" checksum="0C3B5AD3BD0E90A6" modified="2017-08-30" version="1">MQCRVQLGRGVEPSDVNESEANTPMATVLLRLSVIDLVATHILWHPALVTVSSPTALLLSGKLDLHPLFPASNQSLVDHLSCTCRSYDSCPHPIWPSTLDTTCHHDLPFPLACSAESTTLASISVLLDIHSVVAKDDDVMAFDVERTSTWTGVKKGNVGGFKSLKVAVHPEPSFILLLRSPVQACTFNIPGLASSIHGQDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIP4</accession>
    <name>A0A1Y2AIP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GPCR fungal pheromone mating factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_456634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIP4"/>
    <dbReference type="FunCoup" id="A0A1Y2AIP4">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AIP4"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004933">
        <property type="term" value="F:mating-type a-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001546">
        <property type="entry name" value="GPCR_Pheromne_A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00900">
        <property type="entry name" value="PHEROMONEAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY22441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="299" mass="33881" checksum="83E55AAB0BE27FC7" modified="2017-08-30" version="1" fragment="single">MRYPDYAIWSFIAFFAVLLPSPWHWRMANIATICLISWVALANLITFADVFIWAENYGDHSPIWCDISSRLLQILNYAIPACSLSQMMRLESVASARRSVISATARTRRMYWEAALCVGFPLLMMAVLSTIEGHRYDIVENIGCRQPQYLSWLTLLLNNAIPMSISILACIYGCLAIRWFLVRRLQFRALLASADSGLNISRYFRLIALAFVEVLVLLASNIAYLVLTLKGDDIRPNVGTSWATVHSNYDLISQYTEASSSVDAYSLNALYIYMTALYSLTFFIFFGMGEEAIAEYAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJV0</accession>
    <name>A0A1Y2AJV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_562195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJV0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJV0"/>
    <dbReference type="InParanoid" id="A0A1Y2AJV0"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="10"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="293" mass="33204" checksum="6872401CF54B1D3D" modified="2017-08-30" version="1">MPRFLRTKYQQYKNDTFQLSTWLAEAAFNFGYPLDAFAEAEGVIDGTERRTAQQLRNAKKKAKGRAKAKGGALENQEQNVDGRTVTQVQGDYVLKIWQFKEMASFLVEQNAPIAIELIRLLRRCISTRVQCLRRFSSAPDVSIESHQHIINILSDIAVRFEDHRAAQTEDPIRRVDVPSRLLADSNASRYAPLAAEEDNNEAEDMPDINLPEPPRYPSVPIITLQAHFVPEEDIEEIVMALLTFFADIRSIREYISALWTDYGDERINLMTAAVTTNTALELLRSAMTISPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK64</accession>
    <name>A0A1Y2AK64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_367939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000086">
        <property type="protein sequence ID" value="ORY22894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK64"/>
    <dbReference type="InParanoid" id="A0A1Y2AK64"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="108" mass="12130" checksum="0DDFD1055AEBF16C" modified="2017-08-30" version="1">MTDHLDLAGVLDEPRRVDLRQARWVDLTSGFSYRVVSRPGSHASRLPFPPHQESGYALGRIDERDSDLTLVLPTLGQTSFISSESGYMLQPLVDPDADWSGRKHIRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK65</accession>
    <name>A0A1Y2AK65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_368758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000086">
        <property type="protein sequence ID" value="ORY22906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK65"/>
    <dbReference type="InParanoid" id="A0A1Y2AK65"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="298" mass="31767" checksum="4CACBF84571C09B5" modified="2017-08-30" version="1">MPVSAPTGKPSTSAITISREQSGPLVPAGSSSQTSGQSATTILSFQAGTNKYFLKRRGSSQAKKSVVEVIPHSNKRQRLTPASIVPLSGLELSQHVTIPESNPPAMEDDTEAYEEHDNSKVGSSLCWIHRRVMLITKLQAVPTLPVPQGGSPNLQQLMVAGGAVESASSIAPSKDVIFPGMTRSSLQPGIFVASSTLLSRFGRCIDNPRDTRAILEDAKALPVSASTASSSIASSSFMVALSELRSTKGYVGAAVDDAQSRILYLAVVEDNINVERELSIMGLVSCYLRPVWRERSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKF1</accession>
    <name>A0A1Y2AKF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_551581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKF1"/>
    <dbReference type="InParanoid" id="A0A1Y2AKF1"/>
    <dbReference type="OrthoDB" id="2565178at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18542" checksum="BDA94B5932539031" modified="2017-08-30" version="1">MPAEPHTPTRPKRTLSKPYNRAPNTSSSAIDDDIRTPGSSSSDDQDSADEYRPPTPNPFFDNEHEVEPDITMLDDDDNDVKPDIKGKGKGKSRPPPKGTSTPKKTTGGSGGKAGTAWTPDETWLLFKYLYPRTKPDWAAAARAVGRDAKSCQNRSVLMQKKLEGAIKAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKU4</accession>
    <name>A0A1Y2AKU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactonase, 7-bladed beta-propeller-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKU4"/>
    <dbReference type="InParanoid" id="A0A1Y2AKU4"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="385" mass="41761" checksum="299B6BCBF344B69A" modified="2017-08-30" version="1">MNPTRLRLLTLVGILGLAYLIFRPRNRGDVVHSLLVSTPSNTSFPFHILTLPDLVPTPLPRTSAVQGTFFPSHIATVNRKRREFLVTNERKDGEVWAVKLSSGIDLVDSVRSGGDEPAHCTTSRSGLHLICANYGSPSVSVSTINPLRHVYTFTIPKHGKSISHPHQIVQHPVLDDVYYVPDLGMNVILVLKLEGSNENPRFSALQRQEISENSAVGARHLAVTPDGKTLFLGAQTSSNVLPFSLHQDGRINSIYHTASLSSLPLHLEASETFALSDVQLHTQELFVLNRRVRPPYIGAGDTMAIIDVSDPDSLSVTQYVELGCWQTREMFHWSDVAGPSLAVTCQGADGNGAGVVLLRKVAGGWAVVNSWDSGRAGAMGIAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL51</accession>
    <name>A0A1Y2AL51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_549686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL51"/>
    <dbReference type="FunCoup" id="A0A1Y2AL51">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AL51"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY23281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33926" checksum="BB455D8964FE232A" modified="2017-08-30" version="1">MSIPASAAGPMPGTLSHYKTGFHTYPFFTTGSLSSTRVVVFIGGLFSGFGDVGYVNALSKAIEIIDWKLVIMHWSGAYEGFATGSLDRDVKEMADLVTHLRSTGHSTIVLMGHSTGSQGVIHYLTTTCPSPHLANSPLIGALPLPAVQGGILQATASTREFTDSGAYDLARSWAAVLPEAQLAMKTGKGEEILSDQACKVLGMRATGYRIWSLADPSGEDDYWSTDLPFEQDGIHAHPISKSFGKLPVPTLALWGGKDELGMPFDKVSPALKRWEEASRGQLETCVIDNASHAVTDDKDRAILGEMVVEWLTKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALA0</accession>
    <name>A0A1Y2ALA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_549646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALA0"/>
    <dbReference type="InParanoid" id="A0A1Y2ALA0"/>
    <dbReference type="OrthoDB" id="2526823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="580" mass="63237" checksum="3C7E8D94407FAA4E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM14</accession>
    <name>A0A1Y2AM14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_361401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM14"/>
    <dbReference type="STRING" id="71784.A0A1Y2AM14"/>
    <dbReference type="InParanoid" id="A0A1Y2AM14"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="132"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="293" mass="32657" checksum="95ADCD0673132F59" modified="2017-08-30" version="1">MTNNDINHHIQWDSTTDEPFLPVPGFPTLRLTPYREGEQADMVELCNHPLVGRYSYLRPYPYDLSHAQWMYDNIINKNLVPAVSTLRSLRESPLQPNTLPPLVTYPLSVLRYSPSYAISTTSNSNSQSTSTPTINSQSTSISAPQSTSTSTSNPQSDSTSIAPSSKSDLSSLGLKDGAFMGTINIFPAERDPSSDKSIPIPRQDQVWMVAYDIFPILQGRGIGSAVLKVFLEEWCEWMNIRIRAEAQRDNIPSSRILAKAGFVHSKDIVKTWPEEKGGGDRLVGVWDWAPTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANL5</accession>
    <name>A0A1Y2ANL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_347800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANL5"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANL5"/>
    <dbReference type="InParanoid" id="A0A1Y2ANL5"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="205" mass="22003" checksum="393E6CBA0460FEC0" modified="2017-08-30" version="1">MASTPLPEAMTTTSTPDTPSPSLDSKGLRGLGISSPVIIENDPLRRSSVERPSAEVGQETILDAPPPPDPLNLHIIAQRGDIPTLVSLLDADPTLDISARDDQGITPLHWASINAHIGMCRFLLDHGADVDAVGGELRATPLQWAARNGHLYVVHLLLSRGADPNVVDAQGFNTLHLITHSSAVMPLLYMVSLPTRAENYVMYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP18</accession>
    <name>A0A1Y2AP18_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_547454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP18"/>
    <dbReference type="InParanoid" id="A0A1Y2AP18"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="84" mass="9813" checksum="440095BB95E940A1" modified="2017-08-30" version="1">MVVYYLAADFIICFLRIGGEKLVDASACMESVRSISSDDRVERGGQIDWTAPICTCILCIFAFRRYIRKYLVARFIFMYRFIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP64</accession>
    <name>A0A1Y2AP64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1</fullName>
            <ecNumber evidence="5">3.1.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Metazoan SpoT homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Penta-phosphate guanosine-3'-pyrophosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_547219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ppGpp hydrolyzing enzyme involved in starvation response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>guanosine 3',5'-bis(diphosphate) + H2O = GDP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:77828"/>
            <dbReference type="EC" id="3.1.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MESH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.7.2" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP64"/>
    <dbReference type="STRING" id="71784.A0A1Y2AP64"/>
    <dbReference type="InParanoid" id="A0A1Y2AP64"/>
    <dbReference type="OrthoDB" id="430679at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000012">
        <property type="entry name" value="HD domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052194">
        <property type="entry name" value="MESH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246:SF1">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="79"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY24286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="272" mass="30031" checksum="B6728277F717D9DE" modified="2017-08-30" version="1">MSPVAITPSNGRANLMMASEDSSPGTPRPLTLTPSPPVSRSGSSFDLSLREDETELGLLLRTLDFAARKHTCQRRKDVDQTPYINHPIAVANFLASTGIQDVRVLQAAVLHDTVEDTHTTVEEIADAFGVDVARIVEECSDDQSLSGLERKAEQVRTAPYKSREAQQVKLADKLHNLESIRRSPPVGWGIRRIQAYFVWAKQVTDICGPSHPALAERLNALYETAYTRVNGVYFPCHPDACAPLTEAEKDRIDSRLRGLPAGEKVCPKPLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APQ8</accession>
    <name>A0A1Y2APQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_321402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APQ8"/>
    <dbReference type="FunCoup" id="A0A1Y2APQ8">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2APQ8"/>
    <dbReference type="InParanoid" id="A0A1Y2APQ8"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="9">
        <location>
            <begin position="173"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="527" mass="57804" checksum="8909E270C0F32F81" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APR9</accession>
    <name>A0A1Y2APR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arp2/3 complex 41 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">p41-ARC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_547536</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APR9"/>
    <dbReference type="FunCoup" id="A0A1Y2APR9">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2APR9"/>
    <dbReference type="InParanoid" id="A0A1Y2APR9"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000220">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY24207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="415" mass="43889" checksum="B8B5993723847DE4" modified="2017-08-30" version="1">MSAPEVHQLSLGPLTGVAFSPDRSQVAVSPNNNEAQIYSKTGDTWELKQTLAEHDKLITAISWAPQTNRIVTCSQDRNAYVWTPTESGWKPALVLLRINRAATCVKWSPNEDKFAVGSGARTIAVCSFDEENNWWVSKHVKKPLRSTVLSIDWHPNNVLLAAGAADAKAYVFSAFIKGIDAKPEPTVWGDRLPFGTICGEFSTPNGGWVHDVAFSPSGDVLAYVGHDSSVSIVYPSGPGSPPTAHISIRCPALPYLSLTFTSESQLIAAGHDCQPVVFTGSSAGWAHSYSLDDPSSGGSKGLTPTATGSRVPSGGPGRLNNEAFNLFRQADSKGVSSRSNSVSAPSSAGMAAVGQDGQLLTVHQNSITFIEPYEWNSSGEVTKVTTAGKDGRLVIWSVAGGKPGGLSGRMGGLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APX0</accession>
    <name>A0A1Y2APX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF159-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_507438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APX0"/>
    <dbReference type="STRING" id="71784.A0A1Y2APX0"/>
    <dbReference type="InParanoid" id="A0A1Y2APX0"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45474" checksum="ABBB73A07E3797DF" modified="2017-08-30" version="1">MCGRYAIALSNEELYDGLQNQLPRMFQGGRPRWEREQDHRPNYNVAPRQRSTVIRRDPESPSRAMLETMQWGLIPHWTKHPPTGALNTINARSEALLDASSGGMWHALKGYKRCVVPAQGYYEWLKRPSAKIAHFTRQPLSVLPSSTIQKPPLIFFAGLYDIVNYASPVESNFQPREGDDREPYPTGNPILLATFTILTTAPSKDLSWLHDRMPCVLQGWDEVERWLDLGESPKGWEEGSNGTGSLLRGVSGLECYPVPPEVGKIGNNSPTFIEPVAERSDGIKSFFAKQSPKKAVKAEVKVPFAKHDPISAKEGIEQEATGIIAEVGDGDEEVGLGDDSNAPNPSAKEEEKPSIKTDKQDEKKPGRLNDIPNSAKGKRKAADEALAEEAEKKERAGHRTKIALVAIQIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ97</accession>
    <name>A0A1Y2AQ97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerate-and formate-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_545806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ97"/>
    <dbReference type="FunCoup" id="A0A1Y2AQ97">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQ97"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ97"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF129">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE C1773.17C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="69"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="131"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="347" mass="37396" checksum="7231FD04B0DAD223" modified="2017-08-30" version="1">MPVAVPSPKPKILGIGYPRFALPEWKELAEAYDIHYFVPGDRKQVVSEVKRLCDEQGPFAAAYVLFGTSGYSPFHRDMLGPLFDQPGFCGLFAQGGAGYDDVDHVWLAEQGCYLSNTPNAVTAATADMGILLMLSALRGSTEGEANARQGKWRDGLGLESDPTGLTIGFLGMGSIGKNMAKKTQAWDMKVLYHNRKPISPEDEASLNATYVSFDELLSQSDVISVNCPLTPETRGILDAKAFAKMKDGVFIVNTARGAVIDESALVAALDSGKVARAGLDVLTTEPCRDTSHPLLNSNKVTVQPHLGAFTKGTILRGEREVFANVKQYMETGTPVNPVNNPVKVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQP9</accession>
    <name>A0A1Y2AQP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5'-AMP-activated protein kinase beta subunit, interation domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_545703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQP9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQP9"/>
    <dbReference type="InParanoid" id="A0A1Y2AQP9"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="356"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="55040" checksum="AB2D923F4BD52896" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR14</accession>
    <name>A0A1Y2AR14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative phosphoadenylyl-sulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_545466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR14"/>
    <dbReference type="FunCoup" id="A0A1Y2AR14">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AR14"/>
    <dbReference type="InParanoid" id="A0A1Y2AR14"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000136">
        <property type="entry name" value="Probable phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="277" mass="30823" checksum="3A6A322022B623B7" modified="2017-08-30" version="1">MSGESSDILTPQYTAEQIAAFNAELEGKTPQEILIWAIDHLDGLYQTTAFGLTGTAALDMISKISLDREEIHLVPLIFIDTLHHFPETLQLAQTASETYLAPLHTYTPPGVSTAAEFSAKYGDRLWETDEASYDYLVKVEPAARAYKELGVKAVITGRRRSQGAEREGLKILEVDERGLIKVNPLISWTFKQVKEYVDKEGVPYNPLLDKGYRSIGDIHSTAAPNPDLIDSDAAERSGRWQGKSKSECGLHSNYWDMKKRFEEKSNPAATATTVETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARH4</accession>
    <name>A0A1Y2ARH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_566400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARH4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARH4"/>
    <dbReference type="InParanoid" id="A0A1Y2ARH4"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="114"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="216"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY25178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="319" mass="35207" checksum="E0B2D85880F0C5E2" modified="2017-08-30" version="1">MGRPPDSDPDDELSTDLAEIATESETKKHDPLRRLVQCSPPGRFQGAWQCFTWTVSKEGPRALYKGASVPAVAWGITDSILMGSLHNYRAFLKAHGFAERIPGTIDIGAKGERLSILGHSTAGLFAGWTNAIIAHPTEIIKCKLQLQLVRPSHEPQTFAGPIDVVRQTVHGQGWTGMWRGLGASFIYRSSFLAMFGGFEVFNRLFKSWDGTSWAMSTPSANFLAGGLASNLYWGMALPLDNVKNRIMTDSITSPRYKGVLDAYSQTWRETYDPSRSTTWNAIARTRNFYRGAVPVVLRAFPTNAAALAVWEGVMRYAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS85</accession>
    <name>A0A1Y2AS85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_544789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS85"/>
    <dbReference type="FunCoup" id="A0A1Y2AS85">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS85"/>
    <dbReference type="InParanoid" id="A0A1Y2AS85"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="149" mass="16631" checksum="BFF385A5823F525A" modified="2017-08-30" version="1">MAEQQVQLQDLDPAQLQEVKKQLDQELDHLTNSYQQLKQAQSKFRACANDINELTPSSKGKQILVPLTSSLYVPGKLTDVDNVVVDVGTGYYVKKTKSEALAHYTTKTTFVQGNLETLQKTIERKQDNVQSVVGVLQMKLQQQPQGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASE4</accession>
    <name>A0A1Y2ASE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_544247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASE4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASE4"/>
    <dbReference type="InParanoid" id="A0A1Y2ASE4"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="241"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="651"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="743"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1241" mass="134470" checksum="BBF73A381E3904B4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASK8</accession>
    <name>A0A1Y2ASK8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_561217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASK8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASK8"/>
    <dbReference type="InParanoid" id="A0A1Y2ASK8"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012169225" evidence="2">
        <location>
            <begin position="17"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="72"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="280"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="512" mass="58227" checksum="28D93EF6E39659B6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASK9</accession>
    <name>A0A1Y2ASK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2867 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_544068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASK9"/>
    <dbReference type="InParanoid" id="A0A1Y2ASK9"/>
    <dbReference type="OrthoDB" id="5350490at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19624" checksum="BF96EBAE28405D51" modified="2017-08-30" version="1">MWDPSPVTYCQPPTDCGIAKLFENANLLDSYVADISEARTQRMRDLAVGALGHPPLSLQFLLKLRDILVTPFGIRTTSSLGKAGAKEDRVEFFPVIKESSDEIILGVDDRHLDFRLSVYRKVTPDRTAIYMTTVVHCHNWLGRLYLFAITPFHWMVARSALARLHHRLEAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASS0</accession>
    <name>A0A1Y2ASS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Postreplication repair E3 ubiquitin-protein ligase rad18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BCR39DRAFT_544613</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASS0"/>
    <dbReference type="FunCoup" id="A0A1Y2ASS0">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASS0"/>
    <dbReference type="InParanoid" id="A0A1Y2ASS0"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="22">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="102"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ORY25247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="372" mass="41517" checksum="7672C93FDA87D281" modified="2017-08-30" version="1">MDMSNHPLLALATDEPPPFPASYPQLQRLDRSIVCPICKEPFSAPVSIACGHSFCSHCIRGSMEVTKKCPVCHESVSEGSIRRNRALEEITDAWDEARPSLIKLSQPPAGPSRKRPPPQPISNDSSLNSLPHLKRRRDSGSRSQSPTKLSTNNHNEAVEFFGSSEEEETSPRENDTEELTEHDEGTCPICSAKMPIVSIPMHIERGCPPIKAAKKVNGSGNQKADWKKVFAGAGKGREKDVEMKRIVKPNYHLSSEKDLRNILSEHGLVTTGDKETLSARVQQWIILFNANLDTSHPKSLSALRAQLTEAEASRKRDKERGKEELGKELETKEGMAKYAKERRGEFERLRKEIMERDKRRAGAAVDTPIEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATC3</accession>
    <name>A0A1Y2ATC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HECT-like ubiquitin-conjugating enzyme-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_589957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATC3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATC3"/>
    <dbReference type="InParanoid" id="A0A1Y2ATC3"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="904" mass="99566" checksum="857C589F7D0DF4D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATS1</accession>
    <name>A0A1Y2ATS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_544347</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATS1"/>
    <dbReference type="FunCoup" id="A0A1Y2ATS1">
        <property type="interactions" value="615"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATS1"/>
    <dbReference type="InParanoid" id="A0A1Y2ATS1"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="164"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY25335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="401" mass="45440" checksum="72934009C18BC0A7" modified="2017-08-30" version="1">MSVNAPSHALQPETSKQKKAKKRAAAEIAANGEGSGDGEIVNKNKRHRKDKPWDTDDIDHWKIEPLPAPTSDTHRPFLEESSFALLFPKYREPYLRSVWSSITSSLDSVGLACELDLVQGRMTVKTTRKTWDPYIIFKGRDLLKLLARGVNAPQAIKVLQDDIACDVIKIGGLVRNKERFVKRRQRIVGPNGSTLKAIELLTDCYVLVQGNTVSAMGSYKGLKEVRRIVVDCMNNIHPIYRIKELMIRRELAKDPKLANESWDRFLPQFQKKHLKTSEKTAKKNATKERKVDPASQPASSTPAAPTSTQAAEPAKKAKKTYTPFPPPQQPSKLDLQLASGEYFLKPTQRDNIERRKREDKQREVASQRRVEREEAFIAPPESAAETVVEKKKKRKRAEELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATV4</accession>
    <name>A0A1Y2ATV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_543072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATV4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATV4"/>
    <dbReference type="InParanoid" id="A0A1Y2ATV4"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="115"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="100617" checksum="5E34CB3092EDB02A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUC4</accession>
    <name>A0A1Y2AUC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_541999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUC4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUC4"/>
    <dbReference type="InParanoid" id="A0A1Y2AUC4"/>
    <dbReference type="OrthoDB" id="2564297at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="777" mass="81350" checksum="CA2F6E90B853F874" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUM3</accession>
    <name>A0A1Y2AUM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_541782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUM3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUM3"/>
    <dbReference type="InParanoid" id="A0A1Y2AUM3"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="5">
        <location>
            <begin position="307"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="43118" checksum="BB25874737BCE658" modified="2017-08-30" version="1">MASGYHLCVELDPIHADDVKAVIAVGDHTIVSASRDGSVGVWGRAQGQSFRLQALLGGHDAYVNSLAHIPHGAGNGFIASGGNSSLILLHSLDTLNPEPAECLIGHSLNVCTLTYSPSLAKLVSASWDHTARVWSETDGHWDTELVLQGHSEAVWGVTVVETGVRLGCYITGSADRTIILWSQRGETLQCIKGSPEPVRSLAMLPESIGFASACNDGLLRLWDLSGNIIRIIRGHTDYVYEVIIGPRGQVISCGEDHTTRIWTDAGDSLGVLLHPCQTVWAVASLANEDLITAGSDGKLRIWTISPERMASDETLRVYNSSVDAAISAKQQVQTDVPPEPGSHVIDIDINISDDAPPLVLSYRPESDPRQAAEEFGTRHALSANYVDQIEEFIRLHTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVB5</accession>
    <name>A0A1Y2AVB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_541062</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVB5"/>
    <dbReference type="InParanoid" id="A0A1Y2AVB5"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="842"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="882"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1058"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1093"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1122"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1202"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="453"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1270"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="762"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY26511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1592" mass="174422" checksum="73EC803513D25A4A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVH6</accession>
    <name>A0A1Y2AVH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_540635</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVH6"/>
    <dbReference type="FunCoup" id="A0A1Y2AVH6">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVH6"/>
    <dbReference type="InParanoid" id="A0A1Y2AVH6"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY26581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="433" mass="48915" checksum="FE6EA51530B55C75" modified="2017-08-30" version="1">MSSLTTAQKLFSHPETRRRDTSTQSLSSISSPNLSSEEEGDTASEASKIEDDPFPDFLWMTTEEPHRSRRIAIMKVHPEVRKLMGPTRLTALIACSVLFLQITIAILLRNTHPFSLPFILTAYIIGGTANQNTFLAIHEITHNLAFKSIRANKLLAITANLAIGVPYAMAFKGYHIEHHKFLGEDGIDTDLPSRIEAIVLNNVAGKTFFATFQLLFYALRPGFIRSQTPTKWHAINLLAVLSFDALLVHFSGWKSLIYLIMSSFFAGSLHPCAAHFIAEHYLMEGPLDVADGDVKGLAQETTSYYGWLNILCYNVGYHNEHHDFPSVPWTRLPALRSLAKEFYEPLPSHKSWPYVTWKFITDPSVGMWSRAKRTGHGEKLEPTIWSWSTKNPSSEDDDDKEDLSEDIVIEQELTERGYASDRETEAEKKTKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVJ9</accession>
    <name>A0A1Y2AVJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_542680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVJ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVJ9"/>
    <dbReference type="InParanoid" id="A0A1Y2AVJ9"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="815"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111742" checksum="8D221ABEF44A90FA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWD5</accession>
    <name>A0A1Y2AWD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_540130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWD5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWD5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWD5"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="579" mass="64072" checksum="425616652FCFAC03" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWJ5</accession>
    <name>A0A1Y2AWJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_469936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWJ5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWJ5"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013050572" evidence="8">
        <location>
            <begin position="18"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY26856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="378" mass="40955" checksum="DEA5FF177DDE0607" modified="2017-08-30" version="1">MALFMVMFLAGWNDASQGPLLPSLQIFYNLDYLVISIIWVFNFLGFMSSGLTNVWLTDRLGFGVVAPLGAAFQALGYVWLCWGAPYPVFVLGYVFVGYGLGLQDAQVNSLTSRLPGASTKMFLMHAVYGLGATVSPLVSTEFVKRVPRIYLYFTVSLGLAIITLVVLALVFRGRTEDQVVGVRPDVEKSASGGKMKRILTTPVVHYMAIYICIYVGVEVTIGGWAVSFILNERGGNSNAGYISVGYFGGLTLGRVILIPLTLDAYHSSIVAIALEVVVWLVHSIPANAACFALIGFILGPMYPIVMMVVVDVIPGELQGGTIGWIASLGQAGSAMMPFITGALANHYGVWILQPLIIAFLGFSLVLWFFVPRPKGWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX58</accession>
    <name>A0A1Y2AX58_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HRDC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_540295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX58"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX58"/>
    <dbReference type="InParanoid" id="A0A1Y2AX58"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="45"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="167" mass="18219" checksum="5FDD8145F26DFCE4" modified="2017-08-30" version="1">MVNETKPVISATATAPGGPLHGIPGSSRSRRTVITEEDATKLQFGDFADGETLTPSDVQQLLLIRNQPGAPPAPDNKVYKTTAEYVNNFANASYAVVASMRESLQAQGSFLNKFEIAQIMYLRPERVEVAVALIPSLERYAHGDEDEGRLQQILDDVRTQARYAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZK5</accession>
    <name>A0A1Y2AZK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_536832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZK5"/>
    <dbReference type="InParanoid" id="A0A1Y2AZK5"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="498" mass="55847" checksum="F2DA4E8A1F85E074" modified="2017-08-30" version="1">MAEKTYDGNHGYEDHIVVNGHELAVPPAYQAPPKATWKGRIWDTFDAPPEERKLLLKLDAVLLLFGCLAWFCKTLDQGNLNTAFVSGMEEDLSMYANQLTTATTMWTVGYCIGQIPSNMVLLYVSPRWWIPSLELVWGLCTLLTYRVTHYRQLYALRFFVGLAESGMYPALHWILGSFYKPSELAKRASLLGTAAGLGSLFSSILQAAAYTNLDGVQSIAGWRWLFIIDAIITLPIAIMGYVFLPAVPGHRQSRPTFWLTQKDIDLAETRMLSVGREPPRGLSWKRVAKYATSWHFYLLPITYMAWDNSVKITAIMPFWLKNAKNPVQRGVSRRNILVLPVTATGIVAGWIGGWASDGVFRGRRWPPILFGALWTMIIAIILVNIPLYTDLRGHFALYYLSGIGTNFAGVYFSWINEICGTDASKRALILAMSNDASFVLQSIVPNFVWKQTDCKSIKPSHVRVLMASRRPKTNQGSLVYCCPESFPLGYDSGRSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZT7</accession>
    <name>A0A1Y2AZT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_565507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY27996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZT7"/>
    <dbReference type="FunCoup" id="A0A1Y2AZT7">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZT7"/>
    <dbReference type="InParanoid" id="A0A1Y2AZT7"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="127"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="225"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="302" mass="33194" checksum="3151E9BA574BC4C1" modified="2017-08-30" version="1">MLEARLKQASVLKKLLDAIKELVTDGNLDCTDEGIALQAMDNSHVALVSLKLVAEQFESYRCDRNMPLGVNLTSLTKILKCAKDNDVVTLKAADDADSLGLVFESPKEDRVGEYEMKLMDIDQEHLGIPDTNYDATITMSSSEFQRICRDLAALGESVKIEASKEGVRFSSEGEVGNGSVLLKQSAGQDRSGGSKKKEVKRDPDEDEEEEEEEEEKPEVDEEGAKTVKKSKSASNDDEPGVSIILEKQVSLTFSLKYLSNFAKSAPLAKEVSLNMSNDVPLLVQFDFEQGTLQFFLAPKVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0H4</accession>
    <name>A0A1Y2B0H4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_576619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0H4"/>
    <dbReference type="InParanoid" id="A0A1Y2B0H4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="281" mass="31743" checksum="86024AC8881ED2E4" modified="2017-08-30" version="1">MSNDMTERVWTESDSDSDLWTESGYDEDDDEEQGWTASDVAPDSDGDLNLIDTRSQGSDESLSALIEEIYPIDGINAFESSGRSPIPWVNDRRDEEEGNFDVVLYNRDDRVRATECTEEEFRQIALTTVMDEVNTAIQSRLTLIPNGLDVYQIRLQSFLAFWRHQDNVRERLNELPGETTGVSTAGENIFLDRLQVLGVQYTFNRADRVGETEIHGSEISVWTTLQLRNGAWEPFLHSDGQECTCDHYSPNSCLAAEIAAQNQRDANREENRTVSTGLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0I2</accession>
    <name>A0A1Y2B0I2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_576923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0I2"/>
    <dbReference type="InParanoid" id="A0A1Y2B0I2"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="711" mass="76049" checksum="629F70E46EA11479" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Y0</accession>
    <name>A0A1Y2B0Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_536862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Y0"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Y0"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="321" mass="33218" checksum="B129F4D54B1A83B3" modified="2017-08-30" version="1">MDLSALTSTLPPGLADAERELGDKFRAAALSITNLYKSGLSYTKQGYQVGYSACLADVLSTVQSSIGAGQDASQTLSRLMDWAEAREIAMAAFAADEDEPPNGPEKTRQSTLAKQALHNLPRHTSTPLADHEVSTPSDSYSIRRISTPTVPESSSSSYQPTPQGIPSSPIALPTAPIPRSSITSARARPSPIRYSHRPTPLASSSSNSTVPVSSTFNPTLPANTPQSLPAAGPQPAQNVQIGSKRPMVDTLMEVEEAGTVHPAPPVTPSGARGRAAKRRSMGLGKEDGEGRDGERRRGGRRHGHGGGGGGGGGGGGQGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B306</accession>
    <name>A0A1Y2B306_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UreD urease accessory protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_468232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B306"/>
    <dbReference type="FunCoup" id="A0A1Y2B306">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B306"/>
    <dbReference type="InParanoid" id="A0A1Y2B306"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="344" mass="37602" checksum="C932E7507D52E4F7" modified="2017-08-30" version="1">MPPSFPYPSTLGAWAPSPLTWAPGTGHLCVSSPGPHNRSGFSTLRASYPLKLLAPSPLPSQPPHLALCYTLAYGGGLVAADAISLSIEVEEDAALILLTQGSTKVFKHRPGLRPASHGQGPGRKQEGEGDGTTRQRMLVRLASRSMLLLLPDSISPFRSSRYAQAQRFILPSDETSSVLILDWVNSGRQADGEVWSMARYSSTNEIFLGSTKTNNSTKSNESLLGEKRLIMRERTLLEQNNRHPKADIAHKLAPYHVYANILIIGPHVFPLLKYLTDLCAMTSQFQAARPQKVIWSFSPVEDGKGGVVRVAADEVEDARAWIREVFDKGGVRDLVGDGLWGRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B385</accession>
    <name>A0A1Y2B385_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_180801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B385"/>
    <dbReference type="STRING" id="71784.A0A1Y2B385"/>
    <dbReference type="InParanoid" id="A0A1Y2B385"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="320" mass="35233" checksum="0F8482638784E3B4" modified="2017-08-30" version="1">MPKDSRVASKRPYGNACQPCRKKKIGCDGRRPACGQCCKVSETCEYIRSVRELRPGSDLMELRLDRLERLLGLNPLESVAGTNTSIHSHQSLTDGLSESDNKDRESSDSAVALRDVQLDGTSYKVRRGGQGELIYYGVTSMPKGDPLPPSRARSPDNNIIRSADDGGFSHSDLPFLQLLATYKHVSVAPEVGNSLLDAFFCYSGPLYNVVDRMLFLRDMALSGPYFSEFLLMALYASGTRMVDGLSEYERKVQGDMFTKRAKELLAQELDGPSKVTTIQGLLVLSGRECAVGQDSQGWLHAGMVSSFPSRQPLNKLRHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3B4</accession>
    <name>A0A1Y2B3B4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_532299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3B4"/>
    <dbReference type="InParanoid" id="A0A1Y2B3B4"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="281"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="788"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY29319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1323" mass="142357" checksum="8C864D2D44736E4E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4B9</accession>
    <name>A0A1Y2B4B9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_531489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4B9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4B9"/>
    <dbReference type="InParanoid" id="A0A1Y2B4B9"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012169230" description="NAD-dependent epimerase/dehydratase domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="842" mass="92753" checksum="81BF1A7E3F87DD46" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5N0</accession>
    <name>A0A1Y2B5N0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_505334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5N0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5N0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="247" mass="27440" checksum="7C4F5605BBA4A612" modified="2017-08-30" version="1">MPPILPRRVYTFHPQTVKYCTRDELFYKEKTSQLNALIKKVNNKAQYATALKHWTDPGSSIAECVNPCSSCREKAISCFVPVPRHRGRTERNDEFEGVVPLHGIGKRSCSIRVNTATGPRKAWTIPADEAKVYGEIVARTADMINTLLETPSAVSDHDLADRYEDLAKLSDKIGHAKIKRLKRPAVSEPLPPRQRMAAAREEIRKNSGVLYSPTAGPSGTPRTAPQQPSARQSPTPERESEVDGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6D0</accession>
    <name>A0A1Y2B6D0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_558672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6D0"/>
    <dbReference type="InParanoid" id="A0A1Y2B6D0"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="254"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="353"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY30393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="569" mass="62762" checksum="12AA09AAEE7E39FA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B788</accession>
    <name>A0A1Y2B788_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_148581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B788"/>
    <dbReference type="STRING" id="71784.A0A1Y2B788"/>
    <dbReference type="InParanoid" id="A0A1Y2B788"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="94"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="651" mass="71697" checksum="BCC724DCDB8AF4A9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8N7</accession>
    <name>A0A1Y2B8N7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_526910</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8N7"/>
    <dbReference type="FunCoup" id="A0A1Y2B8N7">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8N7"/>
    <dbReference type="InParanoid" id="A0A1Y2B8N7"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="360"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="568"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="38"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY31211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="751" mass="82945" checksum="B6C6DFDA316ACAB7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8P7</accession>
    <name>A0A1Y2B8P7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_526976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8P7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8P7"/>
    <dbReference type="InParanoid" id="A0A1Y2B8P7"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="18717" checksum="D6B5A42DF5525EDE" modified="2017-08-30" version="1">MSTGKYTIAIGSDSAGVDYKSVLKADLEKDPRVKRVIDVGVNKDADDIDTAYPHLGVAAAKKVASGEADRALLICGTGMGVAISANKVPGIRASTAHDSFSVERLVLSNNAQVLCLGQRVIGIEVARRLVKEWLGYEFDHSSSSAEKVAVLHEYDVGGKAKELQGLGDIEFVPGDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8S4</accession>
    <name>A0A1Y2B8S4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1014-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_527112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8S4"/>
    <dbReference type="FunCoup" id="A0A1Y2B8S4">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8S4"/>
    <dbReference type="InParanoid" id="A0A1Y2B8S4"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="138"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27087" checksum="15B06045C96C9667" modified="2017-08-30" version="1">MAPKGGNAKKESGRAKKAENEEKKNQAANKVKEAKEAEEWKDGEKGSSKAEAAAARAAEVARKKAEREALLAAEEASLPSKAKSAPKAGSKKKASTGGILTPTPGGGIAAYSVADPLGLRKSKDAEGDEPTPELSATGLEQMLEALEVVNAKTDKQTLGAKAGLIEQHPERRFKAAFEAYLEREMPNIREEHPGLRQNQYRDKLYKQFEKAPENPFNQAKLAYNASKDEKVDALKQIMDAREAKYRVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8W5</accession>
    <name>A0A1Y2B8W5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_558301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8W5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8W5"/>
    <dbReference type="InParanoid" id="A0A1Y2B8W5"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="918"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="925"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="938" mass="103768" checksum="9AACF9331A6E1388" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B965</accession>
    <name>A0A1Y2B965_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_571881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B965"/>
    <dbReference type="STRING" id="71784.A0A1Y2B965"/>
    <dbReference type="InParanoid" id="A0A1Y2B965"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013073297" description="Glycoprotein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="41270" checksum="8FC5F715C2F4AF62" modified="2017-08-30" version="1">MIWVLIPSLTALTIPLVSAQVTATGPNGPTNPEAPSFLPVGSLVDQSASFSRLLSLNGLDDFCLFAPPEAGPDSLIGNVEAIAVAYCTKPRNAARIIPDGAITAAHFIRTPTYVQIYGFWDGTKVNIPSGDAGGELDPHGAENLGNPMGGNVTSNVPTGSDVFYEEWMSFISYDQFCLRICTAQTNNVTTALQCEHELDIMGCQFVMAIDDFYSANNSFTSCDGDPAPPPGLYPQADGSTSTFRQRYTGTYVDGAGSTGMFTVGQTVTPSAPAYYPAKSNCVTYSSISNGVNTADYSVTAAPQLLVSGSTGAVSSGPSTSSFSSRATGSVSSSSTASASPSRFTSEPTPSTSASTTASTASSGAAAQSSTGAASMTRDLANEGFLLGSLVGGIGVLVGAILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9M1</accession>
    <name>A0A1Y2B9M1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_526388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9M1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9M1"/>
    <dbReference type="InParanoid" id="A0A1Y2B9M1"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="693" mass="75856" checksum="F9DCE1E19C5C7A37" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAH8</accession>
    <name>A0A1Y2BAH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_525761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAH8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAH8"/>
    <dbReference type="InParanoid" id="A0A1Y2BAH8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="96228" checksum="D26034AAE186CBC7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAZ6</accession>
    <name>A0A1Y2BAZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BAZ6"/>
    <dbReference type="OrthoDB" id="2573925at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011965721" evidence="1">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="136" mass="14821" checksum="7DB580F1739F0A89" modified="2017-08-30" version="1">MRFSLLSVAVTYALIPLCVLAVPLHPALVPKDAMALHKRASVPPVSESDAEVESAEDQLEDACTEVCGTVRVEGAQSEREALCSTSGLRATLECATCIDMTWPDTEWEDSATAEYERIFSACHQDTQQLFGTKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBU4</accession>
    <name>A0A1Y2BBU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_593134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBU4"/>
    <dbReference type="FunCoup" id="A0A1Y2BBU4">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBU4"/>
    <dbReference type="InParanoid" id="A0A1Y2BBU4"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="547" mass="58084" checksum="D0B05DA187D86245" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC52</accession>
    <name>A0A1Y2BC52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_493027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC52"/>
    <dbReference type="STRING" id="71784.A0A1Y2BC52"/>
    <dbReference type="InParanoid" id="A0A1Y2BC52"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="109" mass="12236" checksum="9CE7105A5D7C43B4" modified="2017-08-30" version="1">MRPFKIEEIAAVVGQMGEMNGHDIRVPIGHGNGRLLQLGKINLINIKVYIESARYTMIYFGGYSDEEVDVLSEAFLKDVESAELYTRSVRNGSKADEGRYHALSVRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCE4</accession>
    <name>A0A1Y2BCE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_587280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCE4"/>
    <dbReference type="InParanoid" id="A0A1Y2BCE4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="299" mass="32290" checksum="CE521288A8F697D9" modified="2017-08-30" version="1">MSDPINTLPDDVQGSELLPPMPAFLIDSSDLTPPSTPRHVPRHPIKQTSPLRGSAVSAGDSFQPSPIRVSAHSDGSFRTTSRGGSFFSSDGSLRSDKTGDSQDSSSPVEVSNDSTRPILSSPDKSIRSRLRWFSKSRSRIGAELSTQAGSRNHSLRDAGPVPPLPNSTEGSFADQERARSLSPQPALCDECPVPSSFASIRRAESRGPFGNWGSTSYYYEIPDAQSRLEAIRNPHDHEFYSGNARNSDPNNPSDGQGALPSREGGSSLFKNSRAGGRSSEDRSDFPDPKIIIRPPTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCL2</accession>
    <name>A0A1Y2BCL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_525571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCL2"/>
    <dbReference type="InParanoid" id="A0A1Y2BCL2"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="30"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY31825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="304" mass="34799" checksum="4E950979EFAD6B7F" modified="2017-08-30" version="1">MSPKGRKLVCWGIDVDAVAGWLGSYGGEDSSSDISRGMFAGEIGSMRLLKMFEKYKIKTTWFIPGHSLETFPKQMAAVRDAGHEIGLHGYSHENPTALSVEQQRDILEKTFQQLTEFCGRPPRGSVAPWWEVSKEGCEMLLDKGILYDHSFQHHDCKPYWLRTGDKWDVIDYSKKAETWMKPLERGEETGMVEIPGNWDLDDLPPMMFIKSSPNSHGFVDSHVIEQKWKDHFTYIYREHPEGFVMPLTIHPDVSGRPHVLLMLERFIEWVATHEDVEFVTMEEVAADFRANNQVPQGARMPAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD27</accession>
    <name>A0A1Y2BD27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial low temperature requirement A protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_587226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD27"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD27"/>
    <dbReference type="InParanoid" id="A0A1Y2BD27"/>
    <dbReference type="OrthoDB" id="3243926at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="671" mass="74569" checksum="B295E8AC300D7585" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDF3</accession>
    <name>A0A1Y2BDF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_522205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDF3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDF3"/>
    <dbReference type="InParanoid" id="A0A1Y2BDF3"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="213"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="282" mass="31767" checksum="BA9E65CB19D15E29" modified="2017-08-30" version="1">MPRSPSRSPPRGPRGDRDRSRSPVRSAPTRRPKELSFYKKSSSSMGSFSQRRDPLDEMPESAKERMERRDRGEVPARFGGTREHGVRNTMSSIAPQGTAAVGMGSLRRTNDPLDRMPVKGVEADGPDRSNSRNEGFGSQREYDRERERDRDRREKRRDREGGERRSGDGDRRDRRDGDKDREARLAAMGQPVAAPAAAAPPPAGLPRASGRLIEVIANDRMGRKVRIKCMPTDTVGDLKRLIAAQTGTTAQKIQLKKWYTSFKDHVTLQDYEINDGMSLEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDI1</accession>
    <name>A0A1Y2BDI1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_357621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDI1"/>
    <dbReference type="InParanoid" id="A0A1Y2BDI1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040221">
        <property type="entry name" value="CDCA7/CDA7L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169">
        <property type="entry name" value="OS05G0300700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169:SF8">
        <property type="entry name" value="ZINC-FINGER DOMAIN OF MONOAMINE-OXIDASE A REPRESSOR R1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28166" checksum="BCA3A0DF3877D3F8" modified="2017-08-30" version="1">MSTSYPPSPMTNGSSGGPSTEPLKTISSRPSSSSSSSSDLSALSVAEVDSEGYHIKPNSVSGNGIIKNKGKGKSKDEKDESKGKNKNKNNKRPLNAVDSEEDIDSEKDKDKVVGKKAKTVGKKDKATEKKAKNAEEVPVEGVVVEEEGEEEEEVKGAYCHQCRTRSHPDEVLRCTRLKQFSRQGPPRACNRAYCDNCLMRRYGMDPEDIRQLGGEDDGEGHVENVDWGYMWTCPCCDDICQNSVEEKKVLNPSEQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE42</accession>
    <name>A0A1Y2BE42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_521162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE42"/>
    <dbReference type="FunCoup" id="A0A1Y2BE42">
        <property type="interactions" value="744"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE42"/>
    <dbReference type="InParanoid" id="A0A1Y2BE42"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="295"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="549" mass="60034" checksum="29155B6F3C3E2BC6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE68</accession>
    <name>A0A1Y2BE68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_521383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE68"/>
    <dbReference type="STRING" id="71784.A0A1Y2BE68"/>
    <dbReference type="InParanoid" id="A0A1Y2BE68"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="5">
        <location>
            <begin position="376"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="793" mass="89000" checksum="62DDF934A388939F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BED2</accession>
    <name>A0A1Y2BED2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_332826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BED2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BED2"/>
    <dbReference type="InParanoid" id="A0A1Y2BED2"/>
    <dbReference type="OrthoDB" id="2576334at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="660" mass="70072" checksum="B8E755098A49FCF3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFL4</accession>
    <name>A0A1Y2BFL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YAF9</name>
        <name evidence="6" type="ORF">BCR39DRAFT_520484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFL4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFL4"/>
    <dbReference type="InParanoid" id="A0A1Y2BFL4"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="5"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="179"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="375" mass="41339" checksum="B6A6F6D2030E6928" modified="2017-08-30" version="1">MSNERQRNIQVHRPVIYGSHARLLTDAEKELAPPGHTHRWTVFFTSATSPPPSAAASSSSDPILEDIDYLPGGADDLSYLVKKVTFRLHETYSNPSRVCDKPPFKVTETGWGEFTVQIRLQFVQESGEKPMNFAHTIKLHHWGPPIEAPLESSTAPPTEDKMGEGTPVKAEVETPAPPTAIETTPKPEEQTQTQSQSQTPGAATGESNPTPGEPTSTSTPAPASASEPMLSQPISVASKYPVHAWQYDELVFSDPPLSFLNILNANPATPLPPRNRRPRNQREEHEIRTGKKSKKTAAPQPSESRQATPAQTIGVPGELGSADVPLEFSAEMEKAEWNRINDARLHIVSEMDRWREKLIAMEKECAKLKEEMKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGN1</accession>
    <name>A0A1Y2BGN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_517987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGN1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGN1"/>
    <dbReference type="InParanoid" id="A0A1Y2BGN1"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="160" mass="17876" checksum="4179BAF7D1FD8FC0" modified="2017-08-30" version="1">MIRPNLLRSLPRYLPRQSTSLARRWASTSVVPPETPKEEASVTSAEADPQLNGYPELPFVSRLRRQPYGWWDMQERRNFGETVPESEELASVFGPDPSPITGSEAVKQVSVAAGLLGIFVYFLYLNSPEAPCVPKAFPYNGLERELGGRPVRAETPEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHG0</accession>
    <name>A0A1Y2BHG0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_516925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHG0"/>
    <dbReference type="InParanoid" id="A0A1Y2BHG0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="52" mass="5723" checksum="2C6FF8F089EEB611" modified="2017-08-30" version="1">MMQEEGNEDEEGRANSGVPCSILLSASIACVLWVLWPSDHGSYVCCHHYLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHG7</accession>
    <name>A0A1Y2BHG7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_191070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHG7"/>
    <dbReference type="FunCoup" id="A0A1Y2BHG7">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHG7"/>
    <dbReference type="InParanoid" id="A0A1Y2BHG7"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000011">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="114"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="540" mass="58816" checksum="19D6FC461B8A2831" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHS1</accession>
    <name>A0A1Y2BHS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_518565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHS1"/>
    <dbReference type="FunCoup" id="A0A1Y2BHS1">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHS1"/>
    <dbReference type="InParanoid" id="A0A1Y2BHS1"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="727"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="684"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="845" mass="92032" checksum="DCFF4ED425E1AA20" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHT6</accession>
    <name>A0A1Y2BHT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activator of Hsp90 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_518468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHT6"/>
    <dbReference type="FunCoup" id="A0A1Y2BHT6">
        <property type="interactions" value="700"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHT6"/>
    <dbReference type="InParanoid" id="A0A1Y2BHT6"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="320" mass="34658" checksum="109EC75ADFCBA36E" modified="2017-08-30" version="1">MGDPKPLTAYQQTYHWRNKNCGPWAQEWIKSSLPGLSVEQGSQSAKISEVTSVTGDCDLGQRKGKLLTIYDLEVEASWTGVAEDGSEVKGSVKVPEVSHEAIDGLSDYVYEFRLSGTSTPAAQTLLTYLKTAFPPILSDKFNGLRPALLAVHGNPDSGATSGTSTPTSAPATTTAAYTPAPPAPAPEPETKKESKSVASTSSVEVTAQLQASAEDIWGLLTDESRIPMWSRSPAKLSLTPGSPFELFGGNVRGKIEQVEKPTKLVQTWQPRHPNWPSGELTGKGFISCLTASLINVNRSLRHYDYCTCSRIRFNYGHFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BII1</accession>
    <name>A0A1Y2BII1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_513539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BII1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BII1"/>
    <dbReference type="InParanoid" id="A0A1Y2BII1"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="241" mass="27124" checksum="006E52A2A50863E0" modified="2017-08-30" version="1">MEAPIDQSAVDSATTSTTPVSDITLFYRMAQDSDLPQLIRYREECGWGVGFLKETWQDPNVPLCIFMAEINGETVDIGMGGWILEQPGAASKKDGWVKLCTSLQVDGSNNPSAKLPTPFLLRWSLLSVRRAHDILASLFILKKYQKFGYGRLALNFLEKLAVDLYGAKVITLDTAAYECTWSEDGKIATDNIGEESNNSKMYKRRGYVQYKDPVPSYPFPRPDDPDYKIHSVYFKKVVQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIN3</accession>
    <name>A0A1Y2BIN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_585617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIN3"/>
    <dbReference type="InParanoid" id="A0A1Y2BIN3"/>
    <dbReference type="OrthoDB" id="2587968at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="548" mass="61249" checksum="95940BB36069485A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIP2</accession>
    <name>A0A1Y2BIP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_513877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIP2"/>
    <dbReference type="FunCoup" id="A0A1Y2BIP2">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIP2"/>
    <dbReference type="InParanoid" id="A0A1Y2BIP2"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="153" mass="17148" checksum="1344F64719881812" modified="2017-08-30" version="1">MSDDEQMDMGGDEGFDGEYDPDEINYEDMDRPEGADEEEALNDQTNGDETMIIESGQPADADLQPRTGKAAKPNAVRVTTPYMTKYERARVLGTRALQISMNAPVLVPVEGETDPLEIALKELAAKKIPLVIRRYLPDNSFEDWKVEELILQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJI6</accession>
    <name>A0A1Y2BJI6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_193590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJI6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJI6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJI6"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="914" mass="100827" checksum="5D95081566D31282" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJK5</accession>
    <name>A0A1Y2BJK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_476507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJK5"/>
    <dbReference type="FunCoup" id="A0A1Y2BJK5">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJK5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJK5"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22814">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="5">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="291" mass="31342" checksum="164E43FB59AFA6A6" modified="2017-08-30" version="1">MPMPCDPFNKLTKFPQSEFAVDMTCQDCVKAVSSALRDIPGIERWDIDLEGKRVTIVGRTPPSHLLSALKSTNRQVIVRGASAASAAPLAPAQAAVSILESPLPLPTSMASTTNSILAAREASLPGMNEEEHSQKVFGICRFVQIAPRLVLMDLTVRLPPPANVGLAPARRAFNVYISSTGNLIDPPTTTGKPFINLGQIVPDKEGYGDLFKEVDGELWEWIGRGCIVEAESNRQPSSPTRSQGAPSTLGKIFAGVVARSAGAWGNDKTVCACSGRTMWEEDREMEKKILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJT2</accession>
    <name>A0A1Y2BJT2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_516252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJT2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJT2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="38133" checksum="DF11C49412B73334" modified="2017-08-30" version="1">MIVRTEPSAVTISILTAKTTGANRECEYCECPMAHSEMKSTMLEPSLFDSEEKAALRKALKDQSKQFLRTVGRLCEREVRGYQRQEKIRRLEGCYEKTKNSLQSSMKVLSSSMSPSQRRSREYDGSAAEYFKCPDKQTNLPAIPSGSPRVSAGSSAHLISEAYTSLFAKNSDNAGSWRNRLKGLHLFKKPRRSNDTDLVEPSVEISGKPNSLSEEDLGSPPSEVLTSALNFYADWNLGNAESSRAWMRAVSGEAVEIAEAEAFISEMAAMINHSRFHGRDSDAVSIASSGSSFYDPSFASSQSTLCGGQEDLRSESPDSGCTFDKGDFVPEPMLGLVSTLCEKSDMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJX8</accession>
    <name>A0A1Y2BJX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_457800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJX8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJX8"/>
    <dbReference type="OrthoDB" id="3223416at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="136" mass="14157" checksum="C57BAA2757E1C3BD" modified="2017-08-30" version="1" fragment="single">SNGSSVLECWQLATPFSISHDPGTSGSAALQLGNLANATYTVLPPRFEGGLHKAPYLQYVAFTSGLANITLPNSTDHVLVHGGAKGLIIAADYHDSNGHITTYPGNTSTIALQIPIANNTAPPHIVLHSGACSRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJY2</accession>
    <name>A0A1Y2BJY2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular GDSL-like lipase/acylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_516676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJY2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJY2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJY2"/>
    <dbReference type="OrthoDB" id="10071171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF2">
        <property type="entry name" value="GDSL-LIKE LIPASE_ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="194"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="407" mass="44264" checksum="C9F70B915308D116" modified="2017-08-30" version="1">MHDPASNHHWVSIWSTAAAPVSLLPDPAAQVLNFDSTTIRQTFRVTLGARRIRFILSNEYNGSNLVVSAMTVARSAPTKAGLTAGSPLIHEKTLHPVTLGRQTTQDIPPGSTALTDDISMELEPSTDITVSIYLASGQSGPAVTGHYDGKTDTWLQQGDATRVRELPDPVSVHHSFYVTGIEGWLPSDEAAIACFGDSITDRGDSNLPYNEYNGWIDVLSARLAHGSLPLSVLNLGISGDQVFAGGLARFDRDVLLQSGVKYVFVHMGVNDIGITPATAEAQDALYHRLVYAYRQIITKAHARGLVIIGSTIMPFLAPASWPTPWPFANVVREGTRERINAWITNEGEFDRVVDFSAAVTDPDHPNRIREKFQLCDFLHPSPEGYAAMAAAIKIEVFEPARLEINGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJY3</accession>
    <name>A0A1Y2BJY3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">And other transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_516692</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJY3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJY3"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="89"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="585" mass="63985" checksum="0422363197C41523" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BK42</accession>
    <name>A0A1Y2BK42_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BK42"/>
    <dbReference type="InParanoid" id="A0A1Y2BK42"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="225" mass="24641" checksum="BB54184B4CCF8B13" modified="2017-08-30" version="1">MAELTSETPVQSIVITGISRATGSCFDRLESWPPQTLSNLDIDTPSISPRDLRVPGPMSESEQTLKVAYQNASALSSILFGVLAKRSSLAQSLTCDVRIRNVPQYAFRWPCHPPRSEEVKEDWLQTVSTRASDMTLAVPSTYQAVSSQYTEGKGRSKSSLLLVAGSISEDGKLINPVTSEQTAAGPTSEDGKSSTKPMTLRIQVDDNVTEFVRRKARHTFFSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKB3</accession>
    <name>A0A1Y2BKB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative maltose porter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_556065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKB3"/>
    <dbReference type="InParanoid" id="A0A1Y2BKB3"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="67"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="540" mass="59856" checksum="642A5E6F0BB17C1C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKL6</accession>
    <name>A0A1Y2BKL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_508795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKL6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKL6"/>
    <dbReference type="InParanoid" id="A0A1Y2BKL6"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="14"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="517" mass="55868" checksum="06221D2834923A38" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKT6</accession>
    <name>A0A1Y2BKT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_509177</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKT6"/>
    <dbReference type="FunCoup" id="A0A1Y2BKT6">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKT6"/>
    <dbReference type="InParanoid" id="A0A1Y2BKT6"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY35384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="612" mass="68931" checksum="4CA9ECA03AC6F67B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKX1</accession>
    <name>A0A1Y2BKX1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_6474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKX1"/>
    <dbReference type="InParanoid" id="A0A1Y2BKX1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="85" mass="10015" checksum="89C14607524C5BB7" modified="2017-08-30" version="1">MSKEVPPLSFLSFLLEHRAVNICQTDPYAIFYQLCQYSGSQLSSSHFCPMKDTRAYQAIHDGNRNRNRNLRNTMLDMERRRLMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLC8</accession>
    <name>A0A1Y2BLC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_509892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLC8"/>
    <dbReference type="FunCoup" id="A0A1Y2BLC8">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLC8"/>
    <dbReference type="InParanoid" id="A0A1Y2BLC8"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="139"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="245" mass="26196" checksum="0B7E5FC12DA384B6" modified="2017-08-30" version="1">MSAGPSSLRCMSRTIPRQIASCSRLPLPLSTFVPHSYTTFTPRSSSFSTSSARSSPFSTSSASSSIVNITSSRPSLLLFRRQTRSVHALARPIDNAGGFEGVPAAAYIGSVGVNGKSTEDVSTSTNKSRPTIRAKKSAITMTPAAITRLRELVSSPTEPKLLRIGVKSRGCAGMAYHLDYVPPPGGRFDEVVEQDGVRVLIDSKALFSIIGSVMDWRDNRLSAGFVFDNPNVVDTCGCGESFNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLQ2</accession>
    <name>A0A1Y2BLQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_460379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLQ2"/>
    <dbReference type="InParanoid" id="A0A1Y2BLQ2"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="28279" checksum="73CDF1BB94886E08" modified="2017-08-30" version="1" fragment="single">LLGAASVAAHAELYWPHPLHSKYNPITPEALKDYSMTSPLVTDGPYPCKGYINNPESLMVPAVTWSAGKTYNYTTVVTAPHGGGSVQLSLSYDNGTTWSVIFSYMGGANIEGNTIDFLLPSDAPSGTGLFSWTWFNLQGNREMYQDCAVIDVIDGGAGLNSVDYPEPFVANANVNNCTTIENINVVFPNPGKNVRYGGVYKDTKPTTPAGFTGTNCVGPGAGSGSTSVSSTASSSSTGATGSSSTVIPSQSPTSSFGSSSQSPTSSFGSSSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLT8</accession>
    <name>A0A1Y2BLT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_24741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLT8"/>
    <dbReference type="InParanoid" id="A0A1Y2BLT8"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012914772" evidence="7">
        <location>
            <begin position="26"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="7"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="494" mass="54008" checksum="5AC84F4D9AA539C9" modified="2017-08-30" version="1">MGMGKYQWFIFYLCGFGYFLDLCWAQAGGLVGSAIIQELGIGTDHAGDLSTAFNTGLTLGAFTWGLLVDIVGRRWCFNITCLIASVFGFLVATPSSYGAICFYYLLVGFGVGGNIPIDATITIEFLPKNHRWLLAALSTFQPLGTVFASIIAFCVIPSHSCGADLPSCNTGETPCCTKDSNIGWRYTMIILGGITFLIFLLRFVAFRFRESPKYLLSKGHDAKALDVLYSVAHFNQRPQPTLSIDDFRALEFEDDSIGSYNSDVPINGGQHEARPPAVREVLIGGFSQVFGHLRGLFKDKRNAYLFTVLGVAYIADFWSFSVVGYFLPLILRDKGVDAEQSTADTYRSYVWIYLPGVTATLVAARFMEIPRVGRKWSMVVSAGLMGVSLALYQLVDSIPANIAFNAMEYWFQSLYNALLYAYTPETFAAPFRGSACGMLSTLGRIASIIAPIASTHVYNGSHSPGVLWLGAGGAWISMFAIALLPGDTRGKQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLW9</accession>
    <name>A0A1Y2BLW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_511688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLW9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLW9"/>
    <dbReference type="InParanoid" id="A0A1Y2BLW9"/>
    <dbReference type="OrthoDB" id="3597994at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="182" mass="19196" checksum="9039AEB90A8E43A7" modified="2017-08-30" version="1">MSSSTGSSTAEPGRPGISKQPPPASANSSALHKAKVNLSYLALGSKAGAAPASIATRSALSTTRYVIRYIVRRLLRYAKYAAYGALITTIGGGLLGTLGSGLAFFAAPSIGLGMGIGVITALTKFGWRHRGNWFRGGIFADMQARAQAGRDGAADEEIDAQGAEERLKRESHRVREDVWMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM03</accession>
    <name>A0A1Y2BM03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_512190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM03"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM03"/>
    <dbReference type="InParanoid" id="A0A1Y2BM03"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="481" mass="50423" checksum="E0E34845B897D3F1" modified="2017-08-30" version="1">MDNLSGLLVHFGPIQPPALLEQLRDCLRKVGARESPTIALDTTHFVATSPITGGDDKGRGGVVDPQYQEAVRANLPVVGPGWLLAVAGERKLVPISGYLLPAMPQITNSQPSPDPAPFRRPDPPSKRSSLPFTSSVPSSPVREEIPRSPSPETIARMSMTGSTIKGASRSASLEVDARPSRQGSIREESRTRQASLPTTEGSRPKSPKPEADGKLDRGFKFPLKGEISATDTSAPPTSAAAVQPSDGAQRDSTSAAKPVDIPSASVNPDIVAPVVSPSIVFPTTTTNGSVVSPTAITAEPESLTSPKLFAGPPMVIVTPPATATEEMKEDLPVPAPPEDAPARSNTIDEAVAKFHEAVGKPSSTTVEPEAAIDEREETTTEDQIAGPDGAVAETGSHVVVSEESVKPNANGQHETKTDKPSFKSSDETSPRRSRSPTATFERPANSRKNTASSSSPVDTHKESTEGALDGEGVSMDEIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMA7</accession>
    <name>A0A1Y2BMA7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_512310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMA7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMA7"/>
    <dbReference type="InParanoid" id="A0A1Y2BMA7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="303" mass="32761" checksum="2626288AC118732A" modified="2017-08-30" version="1">MHEHIRGHGPRGIPFLQEQGPGQEPEGDRHHSRHHHRRHMRGHPTPSPPLGPHRHGRRNHHGHQGFPPPPPLDQEGNPLPPPMDETGNPLPPPRSHRHGRRGHGGPPQDHQRFPPPPPMDQDGNALPPPMDEEGNPLPPPGAEDDIPPPPPRGRYGCPWCQGESDESDTDQPEAFPPPWDRGFPARGGLGDFGGFRGRGGHGGRGGFPGFGGRGGFGLFGGRGGFGSHSSHHHGPPPFHFSGPDMGFEMPMRGPAFDEWPHHHPFGGRGGFGGHGRGGGLSHAHGHGHQQFHPFAQAEHVYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMB7</accession>
    <name>A0A1Y2BMB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_35596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMB7"/>
    <dbReference type="InParanoid" id="A0A1Y2BMB7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="458" mass="51592" checksum="F9883D0D89C4583B" modified="2017-08-30" version="1">MSAKAAGKLAASASMDISDHELDEEAMHEVERAMGISDHWIPPMKVKRRPKHKTTGGHRSKRHVSQILLHAVAGHLWLEDFRQHQLARKARLGALRAEDQRVAHISFEAVRASWWYPAEYRSTTTPWWIRCAVMPLVWPSALSSSSRPLYPAQPEAVFPTPYDPIVRKRTAESAFRFPQFEAPGDEVNERWARRNELRLGEEVVPFANYIEDVLCAYREIRYREEMQAAMSLSPAGESEQLMLSPPPRYLTPILARHLRPRCEGRTTMVSPDPPIYIQDIFSTRSPAPPPPYNACTDCETMVCDVLESPMASGVYQHVHVTGARAEALDEASYEDEVDTVEAFMAPVSASIRSLTSSRPTWSAPLTIGAYPPMASLLSPPALISATPIVSPRPVRATSQHVITQWDHALDLEDQPIFDVEAMFDQQEDQDEQEQEQREATAAVSSGLRAIGRWLGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMQ7</accession>
    <name>A0A1Y2BMQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_509777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMQ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2BMQ7"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="31290" checksum="6F77DFD089745778" modified="2017-08-30" version="1">MDPSQPNELAPPIPEQGAAPTEVPVDGPSSSSPRAIAVYTPPPDPSTSQTPSDLDDTFFEPTISDVRAHQASVLARSRQLNDAPLLTSKYRDEEKSAKEKKRAEKWPETTIRVKFSDGTQIQSIFPSTSPIQPVYAFVRSALSPEVASKPFLLWQPPRTQYPEHPIPVKKKPNAYKTSIIPPANYGPVRGSLTQGLQNGTGGKETLHELGLVPQSVLLVKWDDETMNASGYPAPILDSLKAKSIPLPPTVPKSQSQPDDVKPAESREPAEKKIPKWLQKGLLKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADJ7</accession>
    <name>A0A1Y2ADJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_555094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000129">
        <property type="protein sequence ID" value="ORY20638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADJ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADJ7"/>
    <dbReference type="InParanoid" id="A0A1Y2ADJ7"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY20638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="197" mass="21119" checksum="7F358B8834AA8B8C" modified="2017-08-30" version="1">MGAFDPLITYEKGTYIETDTGNKVSRRAVIAGATNIILGGKSIIQSGAILRGDLRRATAGQHVVISMGRYCLIGENAVLRPPGKIYKGVFTFYPVKIADYVHIGPSCVIEAAQIGHGVEIGKGCILGKFVIIKDLVVLLPDTVLPEGTVVPSLTVWGGNPGRCIESLPETYQETVEARCKGYYQRFRPSPSPSSVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEG1</accession>
    <name>A0A1Y2AEG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_554452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000121">
        <property type="protein sequence ID" value="ORY20963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEG1"/>
    <dbReference type="FunCoup" id="A0A1Y2AEG1">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AEG1"/>
    <dbReference type="InParanoid" id="A0A1Y2AEG1"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="329"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="827"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY20963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="930" mass="104537" checksum="941D9B5B74356A0F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFR4</accession>
    <name>A0A1Y2AFR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">BCR39DRAFT_554236</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFR4"/>
    <dbReference type="FunCoup" id="A0A1Y2AFR4">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFR4"/>
    <dbReference type="InParanoid" id="A0A1Y2AFR4"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY21110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="314" mass="34149" checksum="11DB68128D961EC9" modified="2017-08-30" version="1">MAQNAEPDEQDLAHIHWSWPEFIAANPARSLATADLAMDYFAQSPFFDARSNNASLRTQYRITNPFFSHSDEKVLLPNFTQGFEYIIAHSQPPTLFLVHRREVERGRRDNVSAMYFILDGKVYPTPTLYDAMATRLQNAAHLVTQTFTRLSAAHPPANPRATSQWRATVPTSTSNPETEAPNDQVMDIDVPEERKDDTPTTSSTVAVPDWHLFHALASTRNSLQTLDEQARTPLPARNPADELRAIEATLSGFKVASSTAPTNVKAGTGGGGSAVSPSVRTSGTPMPLPSLGGRAPSLVGVSSSPLASWTGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGW3</accession>
    <name>A0A1Y2AGW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_52281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000106">
        <property type="protein sequence ID" value="ORY21694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGW3"/>
    <dbReference type="InParanoid" id="A0A1Y2AGW3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="156" mass="17290" checksum="A8014D8B3732BB93" modified="2017-08-30" version="1">MHSNFAALQQLASCADDYPDLHLDKHILLCNDNGTGIGPKKAEWHSTIRALQNLLGPEQASEVVRTLAGILYLTTLPTDRSRAAEDGTLEITVSCLGLSTEVVQSYFYERKIGNDKMLAYPAQVQTSRDNLICHLNSKIFQVSWNDKCVPLRSLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHN8</accession>
    <name>A0A1Y2AHN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_552867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000104">
        <property type="protein sequence ID" value="ORY21800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHN8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHN8"/>
    <dbReference type="InParanoid" id="A0A1Y2AHN8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26674" checksum="662F0375E4EF5B10" modified="2017-08-30" version="1">MYGPIDWKGSSISEGLPRIDNDGGGVLPQNQLLHLLEPLRPCGRGALWTVYRSRAQVPGVDSDLKIAVKFSSSRTIAASENTSNPYSWGEARAAIKRDIDVMMGPLAHLQSHAVPSVYGIYVSAVRQQKRDEETWAMILSDGGERVDIGRLQLHERRVILQHYQAIHDAQVLHWDCHPRNWLRSIDPRRVFESKLLVTDFERSFTRDEVIGMGWNWESACEEEMQLVRKMLSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI88</accession>
    <name>A0A1Y2AI88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_562412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI88"/>
    <dbReference type="STRING" id="71784.A0A1Y2AI88"/>
    <dbReference type="InParanoid" id="A0A1Y2AI88"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="195"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="661" mass="72793" checksum="94F69028BD0531CE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AII4</accession>
    <name>A0A1Y2AII4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_508138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AII4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AII4"/>
    <dbReference type="InParanoid" id="A0A1Y2AII4"/>
    <dbReference type="OrthoDB" id="2564350at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="282" mass="29917" checksum="58F150CB301739B9" modified="2017-08-30" version="1">MSTSIAESISTSTSIPIPTASITSVPLAPTPATVSISASASASISVPSAETSKLTNGQRMARGLPLLPPSRRITGLKPKRSSVPTSSTPPVYVIRLRNPADGSEYGVISRSPEDNKNGDLVDVAPDMTQAMKFAFGPDGKAQEGPFDIYPSVTDQSISYANMGWSTYDNDGLLHINLKLNHLLASSISSTEEIINPVLAPLTTGSPDEAHSLPAQGAMWTYDRQSRRLLAHYRNVDGSIIPTKFTTGGDCQHTICLVADIEAFQNDLGADAIELHLLATVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKX0</accession>
    <name>A0A1Y2AKX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_363162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKX0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKX0"/>
    <dbReference type="InParanoid" id="A0A1Y2AKX0"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY23218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="462" mass="49352" checksum="51B373D630570C25" modified="2017-08-30" version="1">MSQPTHNNAPELDASHPKRREQLKGRNPLTWNLTKPQQGPASLALKNHFIAMVGEYVGTVLFMIFALGGTNVALIPSTSITGDTTSGQDGTQASTVNTSNLLYIALSFGFSLAVNAWIFFRVSGGLFNPAVSLGMVLVGALTPLRGALLTFAQIVGGITGAAIIQAITPGTLNVRTTLGGGTSIVQGLFIEMFLTSLLMLAILLLAAEKHKATFIAPIGIGLALFVAELLGVYYTGGSLNPARSFGPAVVLKTFSGYHWIYWLGPALGATIAAGFYRMLKWLQYETVLGPETEEDESPKTSGPANGGTQDIEKTAGTGPTAPAGRTLALSGPGLADLHTEGPNSGVYDLERHPGPLENRLDRIEMLLQQLNASRMGNESRLSTGTYVDEPQHHHHKKVIAPVHEERRYVSAPTTEITEDTRYIPTERNTVSGRTEGEGNRHAPFTHGVAGSGPRDHFDVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL40</accession>
    <name>A0A1Y2AL40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_595631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL40"/>
    <dbReference type="STRING" id="71784.A0A1Y2AL40"/>
    <dbReference type="InParanoid" id="A0A1Y2AL40"/>
    <dbReference type="OrthoDB" id="2576082at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="43520" checksum="DBDBD72CF6D76194" modified="2017-08-30" version="1">MSDFLWISASSPLFFYSPNPHYFAYTSTQGHWSGDRDNTSLVAGNDTYKTTYGPHIGVLLPQITALSFQPIWSDPNQAYNTTFQINENAASTWTAGQTYFRPPRDFEPGTFVLNITCTVISCSDSPFAFRGAWIGTKLTPDGSVMQNVTIDDTSPAISYRGFKLLTVPSSSSSSASPDSASTSIQPTDADYNSTLSVTETAGASANVTFQGASIQVTGVTAPSLGAYTVILDGSPYSTYSAEDNVTAHSVLLFFATNLDTTVQHTLLLTAEAATGSEGVGLVIDSFIASGPQGSTGFPIPGTTTTITGGIPASTSTGTIPIGTGAVPTSPQAVGNAAPGTGAPNAGAIVGAILGSLAGIGLLVFLFRKFGPHLPKKEDKKLNPWDEANLLQNMKNEEVHVTTAANQRYIYRELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN84</accession>
    <name>A0A1Y2AN84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_566785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN84"/>
    <dbReference type="InParanoid" id="A0A1Y2AN84"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="494" mass="54879" checksum="763B335103231905" modified="2017-08-30" version="1">MDAAEEERKTGEEDKQIAVVSLENRAEVEITDIVEASEGAYTKAEFDRLLWKIDLILWICGGVQQADKTSISTQATFGLRTDTHLVGQQYSWLSTVFYLTYLVCEFPGNIILQRFNVGRALGCFMFAWGIIVLCVAFAKNFADLMVLRALQGAAECTISPGLLIITGSWYTKREHPVSFGAIAALINYGVGTHAKNHPGGLAAWKGISLFLGSLTIVLSVVVFFVLGTPREVPWLNERERKMAIARTVANQTGSDRAKHEKFKWNQFRNAFKDPQTYFFFFITVTCQMPNGGVTTFGNLVYTSFGFSALDTLVKGTIPQSLVSVAHFIVVGLVCLRWPKTRFICTLLSIIPAFVGMLCLGLIKTTPRIFKWGLFLMTVTGNILLASNVAGRTKKSVTATILFVAYCTGNAIGAQLFQAKDAPRYIPALIACACLFGVEFVGLVLWRYYYIFKNAQRDRRAAALGLTETDIEHLGRLAAEADTDDYENEHFRYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APH0</accession>
    <name>A0A1Y2APH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_582401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APH0"/>
    <dbReference type="InParanoid" id="A0A1Y2APH0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="637" mass="70791" checksum="09197338E97ECD17" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APZ7</accession>
    <name>A0A1Y2APZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_316421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APZ7"/>
    <dbReference type="FunCoup" id="A0A1Y2APZ7">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2APZ7"/>
    <dbReference type="InParanoid" id="A0A1Y2APZ7"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY24659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="143" mass="15560" checksum="90043E855EE3C986" modified="2017-08-30" version="1">MLHLKSMINVIDNTGAIKAELIHVYRVKQARKKSVGVATVGDEVKVVVQKARGGPTQLGGREVIRPRKGEMWKGVIVRVKKEENRLDGRQIRFDESAVVLLNNKGEMLGSRITGPVSASLRNIGGSAAGGRWSKILSLAPKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ20</accession>
    <name>A0A1Y2AQ20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_561576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ20"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQ20"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ20"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01951">
        <property type="entry name" value="lectin_L-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056573">
        <property type="entry name" value="Lectin_L-type_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="5">
        <location>
            <begin position="210"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="624" mass="69676" checksum="DABCE27BA11E88DD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQA2</accession>
    <name>A0A1Y2AQA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_546771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQA2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQA2"/>
    <dbReference type="InParanoid" id="A0A1Y2AQA2"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="118"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="408" mass="45639" checksum="22E37F5089BF0052" modified="2017-08-30" version="1">MTAVLPQPSAVFGQTPIQYTAKYPVASRRINANDKDTKKYYETSYEPNLEWWSTNQANYVKPAEDPLPEGFPQQVSSPSLWDGKILASQPEKWLYTFTANDLEVLEQAHSHFVSLNLTNNDITQETFPIPTTSPLYVTLKHASEEVKLGLGFQVLRGLPVDHWDRSKQLQIFAGISAYIGKDRIAIGDKVVTHLRDITNLPADSRPPIVVKGQTSGNQVFHNDGAAGVVALITLGVAETGGLSQLSSVAQTYNELARTRRDIIRELAKNDWVNKSAPRGRAQIHAINEGQEVISLYSRRPFFGFYESDAEVPPLAEAKHLALDAVHFTAEKFSIDLELQKGDLEYFNNLAVYHARTSSKDSEKNQRHLVRLWLSNGEEVLPESLVESFHKAREESKSASGWPLEAWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQR7</accession>
    <name>A0A1Y2AQR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_486013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQR7"/>
    <dbReference type="FunCoup" id="A0A1Y2AQR7">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AQR7"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18416" checksum="EA632CE06CD89A6D" modified="2017-08-30" version="1" fragment="single">MSTVYLVTGANRGIGFGLVKLLAGRPDAFVYAAVRNPTKSAELVDLANSFKNIRVLKADVVDEKELKAAAQIIANESGHIDVIFANAGISEGFNKVAAAPLETYRKNFDVNTLGTVATFLATYKLLEKTKRPEGGVFFAVSTKLGSIGDGIPFIDAATYGASKAALNYIVKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARH1</accession>
    <name>A0A1Y2ARH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_471705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARH1"/>
    <dbReference type="FunCoup" id="A0A1Y2ARH1">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARH1"/>
    <dbReference type="InParanoid" id="A0A1Y2ARH1"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000003">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="9">
        <location>
            <begin position="170"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="8">
        <location>
            <begin position="365"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="500" mass="54711" checksum="0E0ED6FC8896BC76" modified="2017-08-30" version="1">MQAFRERLQKQPEAGPSQLRDSNHTSNATPLSVATPVSTSSGANGPTGSSAPYNGTQGKPIPSATAEVSRKERFQKKKGKNKADPQSSSDAKGGKLSNAEKAAKKALKLERKKAAEQKRIKKLGAAPVNRNGGERTGPKNLQEQRRAASRAAPWVDLARMARCDNPGQMLNEEVSAFYQFVSPTREEFEVRLYLIELITRAIRKLWPDAIVTPFGSWQTQLYLPSGDIDLVVEHHNVGATKSSRALHLGALGRALREANITDTVAVIANAKVPIIKFVTLDGRINVDISLNQTNGIASGKIINQYLDVIPGSRQLIMVIKSFLSQRSMNEVFTGGLGSYAVICMVISFLQVHPQLRSSQMDAEKNLGTLLVEFFELYGRNFNYDYVGLSIRRGGFYFDKRARGWLNDSKPFLLSVEDPQDPDSDIGGGSFGVRTVRGAMAGAFELLTGRMFERSTQMAEIHAARGNDDILDDLSILSAVMGFSPDVSILLEDSQIPADKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARJ2</accession>
    <name>A0A1Y2ARJ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_545242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARJ2"/>
    <dbReference type="FunCoup" id="A0A1Y2ARJ2">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARJ2"/>
    <dbReference type="InParanoid" id="A0A1Y2ARJ2"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="347"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="438"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="897"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1189" mass="130070" checksum="427BDDDA85C012AE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARQ7</accession>
    <name>A0A1Y2ARQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_581405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARQ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2ARQ7"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF188">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="56561" checksum="B35C13169815C3AA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS42</accession>
    <name>A0A1Y2AS42_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_545930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS42"/>
    <dbReference type="STRING" id="71784.A0A1Y2AS42"/>
    <dbReference type="InParanoid" id="A0A1Y2AS42"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1104" mass="117053" checksum="C0521FDA0CB0D93C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASA9</accession>
    <name>A0A1Y2ASA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_544106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASA9"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASA9"/>
    <dbReference type="InParanoid" id="A0A1Y2ASA9"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="231"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="444"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="734" mass="81720" checksum="3337AE79115CF621" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASI7</accession>
    <name>A0A1Y2ASI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_499129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASI7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASI7"/>
    <dbReference type="InParanoid" id="A0A1Y2ASI7"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="430" mass="47560" checksum="A526BAFF6F61BC10" modified="2017-08-30" version="1">MLFQISKDKVFGGDALTYTFQSRALGNTWATFGVFIPPNADRTKPVPVVWYFPGIVVNYHAGFARGGFFDEASKRGIALVFPDSSPRGTGLAAEKVDYRLGPGASYFMDTTAEPWCRYYKMFTLITEELPQELRDEGLPLDFTRQGCIGHSGGGHTAMQLHLLKPETYFSGSGMAPMCDFMASEIGRSVIPQMFEGGFDEFRRFNVPDLIRNSSGRKLNILVSVGTADPGLGPGRMMVENLENAVAEAEIPSTDFTWEWDEGYNHSYHYNATIASRHVAFHADILSKISPGPAVNKKRVDLAIPPWLTRSIKQSAPLPEYGADIGTWIESLANTHTILVFIHSGSGDEQVRKICEWTKHYVATRPIPDEEILLIDVNGHPFQDAIGVYHATVKSMSSWPLCYAHHLFYGGVNNLIVTTSGVDGRLGRPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASK5</accession>
    <name>A0A1Y2ASK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_580152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASK5"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASK5"/>
    <dbReference type="InParanoid" id="A0A1Y2ASK5"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="210"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="601"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="4">
        <location>
            <begin position="767"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="996" mass="105903" checksum="F54B210C0A428E01" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT03</accession>
    <name>A0A1Y2AT03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_589997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT03"/>
    <dbReference type="InParanoid" id="A0A1Y2AT03"/>
    <dbReference type="OrthoDB" id="2565127at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="170" mass="19052" checksum="D7037D970EDFFF02" modified="2017-08-30" version="1">MNSSTFPSPSRTVSPVSSSSYHLAMRPQIDEDMSYMKQEPSSGVSPVFHHLSLTRSASPSAYHHHGAYTHQTPTSRTRLTHRRTKSLYTHPRQLGFMLLPLPLAAQPYPSPLSPCTNPLSRRTPFPTTSDASNIHERHMMVNPQIAAHLKRGGTVRVRSVDGDRCWRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATL1</accession>
    <name>A0A1Y2ATL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_277635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATL1"/>
    <dbReference type="FunCoup" id="A0A1Y2ATL1">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATL1"/>
    <dbReference type="InParanoid" id="A0A1Y2ATL1"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012214845" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="235" mass="25233" checksum="D0E133EDB0141945" modified="2017-08-30" version="1">MRSFAYIAALLSLSLPLIRAIDISGSLMLDAFQNISTISPSSRIILDNGAKSAFITLDGSFTLYGISPGEHILTPHVPGYTFIPLFLTIPTSATPTPHVQPYAPNRLPLATTLPSLPYPLEIRPVAREDYYTAPPGLNILGLLKNPMVLMMLFSGLMMWGMPMLTKQLESDPELAAEVAATRKRMQGMQNMDWTGSLSKALAGTEETPAINSGSGSSTPSRGANSNRGKRGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATP0</accession>
    <name>A0A1Y2ATP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_498733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATP0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATP0"/>
    <dbReference type="InParanoid" id="A0A1Y2ATP0"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="534"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="597" mass="66899" checksum="1696526490437F19" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUA1</accession>
    <name>A0A1Y2AUA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_541934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUA1"/>
    <dbReference type="FunCoup" id="A0A1Y2AUA1">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUA1"/>
    <dbReference type="InParanoid" id="A0A1Y2AUA1"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000411">
        <property type="entry name" value="RNA polymerase II transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="432" mass="47124" checksum="81B4C0693A66DC88" modified="2017-08-30" version="1">MTYILRDLTPVVAHVDSDAIRATYGVAEIFNRPRLTLPACYARPIGDDSEKSSWIVGDELAKTRSEARFEEKYQLQWPFRTSTSTVIEDWDGREYVLSHVYNLLDVRLSTNTAPLLLVLPDLTLEAQARYCQLAFEGLNVPGLSILPTPLAALYALGQTTGIVLHVGPRSSQISIVVDSVVRPECSTIVDVGSLDCEEFFEGLLKDDLKDLTEEEIKQLSKALYEEDVEIPAAKFGSRMPVNVETEEEAFDVAKRLVGDTAPKKKTKAPEVAADVVAITLPSRQVQVGPVRHRLCEPLLEGKAGGESVAEGMARALDSPTISLSERLAVYEGVAVIGDIAKVRSFGQALMTYLSPYLLSGSEPSSDVQPSKARLLSIPDYFANFKGATTDLAPFLGGSMVTKIAFSDQAGKHCVTKVDYNAKGPICIHTDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVP6</accession>
    <name>A0A1Y2AVP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_541199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVP6"/>
    <dbReference type="InParanoid" id="A0A1Y2AVP6"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="911"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1054"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="400"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="614"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="925"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1250"/>
            <end position="1491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY26307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1507" mass="166524" checksum="53D70DC1FDE450F1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW05</accession>
    <name>A0A1Y2AW05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_255631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW05"/>
    <dbReference type="InParanoid" id="A0A1Y2AW05"/>
    <dbReference type="OrthoDB" id="2565288at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="83" mass="10051" checksum="F19CD19FC4AB5731" modified="2017-08-30" version="1">MATRAPFDPYALPNLMRLSEADEEWYKPRYRAIQDLVHEMEDENNIIAFKISQIRHRLEMRQEALASQPIERSNDFQFFTTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWC2</accession>
    <name>A0A1Y2AWC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 12">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_540208</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 12"/>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWC2"/>
    <dbReference type="FunCoup" id="A0A1Y2AWC2">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWC2"/>
    <dbReference type="InParanoid" id="A0A1Y2AWC2"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000044">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="197"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="352"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY26786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="437" mass="47570" checksum="A44A23161655D7CA" modified="2017-08-30" version="1">MSSAPVFKLAPGIQSYDWGKKGSASLAAQLGQTCIPGFEIDENKTYAELWMGTHPNVPSKSGDKLLSDLLKSDPSLIGDKVVSAFPDAKDGNLPFLFKVLSIGTALSIQAHPDKTLARKLFDERPHIYKDPNHKPEMAIALTPFLAFLNFLPLPTILLHLLSVPELDLFISPEITTELAASLTLPSTRPPDSFLFEPTVSPPTDSQKEILKKIFGAIMSADEATVKQAIDSLIARYEKKEEIAESEKGLVDLAIMLNEQYPGDIGILCVFLLNVVELKRGDAAFLGADMPHAYISGDIIECMATSDNVVRAGLTPKLRDVETLVSMLTYEAGPGSKQLQRPVSFGSDDSTKLYDPPIDEFSVLMLSLEAGKTTEHRAIDGPSICVVTEGKGTVNWGESEAEEAFSRGDVLFIGAGKEIKWEAQEPVELFRAYVEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWE5</accession>
    <name>A0A1Y2AWE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_594660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWE5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWE5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWE5"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="345" mass="39042" checksum="7A0DBFA285A86A58" modified="2017-08-30" version="1">MPAQPYEFDNSGLPPIPPYVPGKPTSLDIDWADLRELDLSLLDSPDPEVVKRLVKTTAQAIREDGFLFVKNYGMTLEQVHRQFALGKYCFDNMTEEEKVRLEWDPSLGHYQGYKPRSGWGKARLSVDDIEGMNYYAPQFADHNLVPKCMHPFMEEIAHFVDYASTSINRRLLCLLSRVLELPDDYIYDHVQSKGDVIGEGYLRHALYHPQHGEGNGVRLYGHTDYGTTTMLWSVPVSALMVLSRDNKWRYVKYNPGALLINLGEVLEVLSAGHFKATLHRVVLPPDDQLEAERLSLILFQAVKSDLTLQPIEEAPLIQREGEVLAGTVFPAYKALMEAGLKVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWN7</accession>
    <name>A0A1Y2AWN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="5">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PRT1</name>
        <name evidence="8" type="ORF">BCR39DRAFT_540010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWN7"/>
    <dbReference type="FunCoup" id="A0A1Y2AWN7">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWN7"/>
    <dbReference type="InParanoid" id="A0A1Y2AWN7"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="767" mass="87730" checksum="E1044369AD3B1B03" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWY8</accession>
    <name>A0A1Y2AWY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_539135</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33503"/>
            <dbReference type="ChEBI" id="CHEBI:6076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:33504"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWY8"/>
    <dbReference type="InParanoid" id="A0A1Y2AWY8"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1227"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1293"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1362"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1396"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1489"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="189"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="895"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY27081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1518" mass="167492" checksum="7AB3024B02E8F792" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX88</accession>
    <name>A0A1Y2AX88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain dehydrogenases/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_594574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX88"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX88"/>
    <dbReference type="InParanoid" id="A0A1Y2AX88"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="310" mass="33119" checksum="3CA13C957022B628" modified="2017-08-30" version="1">MVAQSAVLSSNSSLATSLPAGMVAVFVGATSGIGEYALKAFAQQAKSPKIYFVGRSKDAADRPMLCQQILAKEDSINLLFQTQGTMLMDKTSEGLSIPYVLPVTSRILFTLNLLPALQKATSLKRVVSIFAGGHEGAFDENEWAEYANKKPMKARAHLASMITMANNVMARQAPDVSFIHNYPGAVRTPFGKDAKGLMAAIRVVFNFVGYFAIKYLPPAECGALQLYGATSARYPPAAGEAMGVPLSDDVPVARGTDGQAGSGSYSSNFDCENVSLDVDNHLAEAKADGAEERMWAYIMGEIKQITGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXB7</accession>
    <name>A0A1Y2AXB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_469965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXB7"/>
    <dbReference type="FunCoup" id="A0A1Y2AXB7">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXB7"/>
    <dbReference type="InParanoid" id="A0A1Y2AXB7"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="536"/>
            <end position="538"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="588"/>
            <end position="589"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY26867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="710" mass="77524" checksum="E8DE19A7846D96ED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXD2</accession>
    <name>A0A1Y2AXD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_539027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXD2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXD2"/>
    <dbReference type="InParanoid" id="A0A1Y2AXD2"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="56"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY27212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="892" mass="97017" checksum="96FD418DE3E1010D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYE7</accession>
    <name>A0A1Y2AYE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroxy-acid/6-phosphogluconate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_540034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYE7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYE7"/>
    <dbReference type="InParanoid" id="A0A1Y2AYE7"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009560">
        <property type="entry name" value="PRK13017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="6">
        <location>
            <begin position="91"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="7">
        <location>
            <begin position="416"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="640" mass="68099" checksum="95562552C0D0803A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYM0</accession>
    <name>A0A1Y2AYM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_537847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYM0"/>
    <dbReference type="InParanoid" id="A0A1Y2AYM0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="86" mass="9015" checksum="BB711D1F31A63752" modified="2017-08-30" version="1">MYGGHWSPQSMYGMMSPYYAGGLGIPYLSGMGGYGMGGMYGINPTMYGMGLGGLGMGGLGIGSMGYPYGMMMSNPYMYSGMYGVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZC1</accession>
    <name>A0A1Y2AZC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_588996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZC1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZC1"/>
    <dbReference type="InParanoid" id="A0A1Y2AZC1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY27918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="382" mass="41167" checksum="F95C54F6808208F2" modified="2017-08-30" version="1">MSSGLKNVVIIGAGLGGTNAIEAIEHVLPATHRMVVITENEYAYFPLAALRAATVPGWEEKVLGDVNTLFPKGSRHVVLPGTKVLELKEHSVKVDKVRPGFEEEIAFDQLVYATGSTYAFPFRTCDRSKTSSEVQVLFRTFQAAIKKAESILIVGGGGSGVEFAGEIAAQYKGHKKITLAHTGALPLVNTGWKEKVGRNVQRQLKDMNVVIEPSSKVNTKGLSNGPIDRQLFDLSNGRTVEADFLIVAHGIKPRTELMRTFLPKALDRDGFVRVKPTLQVVSADGSLDHLFAVGDVNDADPTKQAVWADAHGPVVAANIAALASGRAPNKTYTSGTRLGVFSLGPSGGAGQIYFGWVAGARLTTMIKSKVLFTDEFKKNWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZQ1</accession>
    <name>A0A1Y2AZQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_506050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZQ1"/>
    <dbReference type="FunCoup" id="A0A1Y2AZQ1">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZQ1"/>
    <dbReference type="InParanoid" id="A0A1Y2AZQ1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000157">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="56"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="440" mass="48682" checksum="C2F714C9805D5E9E" modified="2017-08-30" version="1">MLLQATRSTVARSAVFSSSSSAIARRSVSAWANVPAGPPDPILGVTEKFKADQSPKKINLGVGAYRDGKGKPYVLPSVLKAEEILYKKMLDKEYLPITGLSDFTKAAAKLAYGENSKPLDENRLAITQSISGTGALRIGTAFLARFYPGAKAIYLPTPTWGNHIPIAKDSGLEVKQYKVKRYFDKETVGLDFEGMKADIKAAPEGSIILLHACAHNPTGIDPTEEQWKELSVLMKEKKHFSFFDMASPRFCAYQGFASGDIVKDAFAVRYFVEQGHQILLCQSFAKNLGLYGERVGAISFVCADKEEKARVDSQLKIIIRPLYSNPPIHGARLVHTILDTPELYKEWLVEVKGMADRIISMREKLYNKLVELKTPGEWGHIKSQIGMFSFTGLKPEQVDKLAEKSSIYLTRDGRISMAALNESNVEYFAESVSKAVKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0N0</accession>
    <name>A0A1Y2B0N0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_537550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0N0"/>
    <dbReference type="InParanoid" id="A0A1Y2B0N0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="70" mass="6949" checksum="DD789F66F92FF19C" modified="2017-08-30" version="1">MRSSEVKSVSSSSPNDIVGLGFSRRRTFDSAEASGSRGPGSSDGVAWSTGSGSRLGVASPTSGGVPWSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1E6</accession>
    <name>A0A1Y2B1E6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_534562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1E6"/>
    <dbReference type="FunCoup" id="A0A1Y2B1E6">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1E6"/>
    <dbReference type="InParanoid" id="A0A1Y2B1E6"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="386" mass="42576" checksum="C3CB3F4DF3E66F1B" modified="2017-08-30" version="1">MRAITSQGIRGGCKACRSAARVTTSAFSSSAVVEKQYSPTIFSGIQPTGIPHLGNYLGLFQPFLELQASSPPTTPIYLSVVGLHAITLPQDPVKLLEDRKNALAALLAAGVDPERTILFFQEDIREHSELAWILNTLTSVGRLQRMTTWKSRLATSRSSTLDQISESDLRLGLLAYPVLQAADVLLYKTTLVPVGEDQLQHLELARDIAQMFNREFGPVFPIPEVQIVPSKRILSLKDPTSKMSKSAPSASSRILLTDPPAMILSKLKSAITDSEPTITFDPISRPGLANLLTIWSSLDDEKQGSRRSPQQLAEYANENKWGMKRLKDEIGEILVDKLSPIGESFEKIRKDESYLSEVAKKGRDRAGEKAQEVMLEVRKVIGLGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B228</accession>
    <name>A0A1Y2B228_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_208679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B228"/>
    <dbReference type="STRING" id="71784.A0A1Y2B228"/>
    <dbReference type="InParanoid" id="A0A1Y2B228"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="106"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="394"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="493" mass="55349" checksum="A9DCA4C55C303605" modified="2017-08-30" version="1">MRGKHINKNNNNAFNSSKPQLQQVLNTLIIGKYATSTIPSQAMPISPPASLLSTPPLQWDHTSAWPGLSAESSPESRRACNNAQDAVSSVAFAHQPDGGKARLEDWEIVETLGTGTFGRVLLVRQRPSYRPTAYHPIFPHLYRSLDPHTPSPSATAIADGQLPHFAMKVLRKSEIVRLKQVEHINSERTILERVRHPFIVELYATYQDPLNVYMLLSYIPGGELFSHLRRAGRFTPDVSRFYLASIVLAIEYLHANNIIYRDLKPENLLLDRTGYLRIADFGFAKLIEDRTYTLCGTPEYLAPEIVLSQGHGKAVDWWALGILAFEMLAGYPPFFDDHPLGIYEKILRGDIAFPGHIDPYAKDLIRGLLTADRTKRLGNLRGGAKDVMSHPWFAGVDWGSLERKEISAPIVPRVANMGDSQNFQRYPPPRPHELSGIFGQAYNPETDPYEHMFRDFSFPTSPPPEQVDSQAPELSTDHHDGPRNPTDPVSHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2I2</accession>
    <name>A0A1Y2B2I2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_468472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2I2"/>
    <dbReference type="FunCoup" id="A0A1Y2B2I2">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2I2"/>
    <dbReference type="InParanoid" id="A0A1Y2B2I2"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="341" mass="38818" checksum="09A2FD0314138E0E" modified="2017-08-30" version="1">MSLWVDKYRPRNLDDLHYHPELSSRLRSLAASGDFPHILFYGPSGAGKKTRIMCTLRELYGPGVEKLRIDQRVFVTPSNRKLDVNVVQSNYHIELTPSDVGMYDRVVIQDILKEIAQTQQVDLNAKQRFKVVIINEADALTRDAQAALRRTMEKYMNNMRLILCASSTSKIIAPIRSRCLLVRVAAPTTDEMSKVLHHVAKKERFSLPETAAQQIIDTSSGNLRKALLVFEAMKMQRPDLSGDIEVAKADWETYCGKVADLILQEQSAPKLLEVRGKLYELLSHCIPPTVILKTIAERIVDKVDDTLKPQIVHWAAYYELRMRMGSKKIFHLEAFVAKVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2T9</accession>
    <name>A0A1Y2B2T9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_532935</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2B2T9">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2T9"/>
    <dbReference type="InParanoid" id="A0A1Y2B2T9"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000028">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="14">
        <location>
            <begin position="1252"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="1987"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="15">
        <location>
            <begin position="2331"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2269"/>
            <end position="2294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY29148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2363" mass="267716" checksum="846A81746E58A17E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B347</accession>
    <name>A0A1Y2B347_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="14" type="ORF">BCR39DRAFT_535013</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B347"/>
    <dbReference type="STRING" id="71784.A0A1Y2B347"/>
    <dbReference type="InParanoid" id="A0A1Y2B347"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="13">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY28505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="446" mass="49301" checksum="6B9A698411D832F7" modified="2017-08-30" version="1">MSSLLSDRQKDDLHKAMLSYLHSAGLHDTYEALKRETDNGEFEVDDPKAKWVGLLEKKWTSVIRLQKKIMDLEARNAALLAELASPTRATSSSSSSSTPFLPRAPARHTLTSHRSPITKVAFHPTWTVLASASEDSTVKIWDWESGDFERTIKGHTKAVTDVDFDSKGTMMVTCSSDLTIKVWDPANEYKNTKTLHGHDHSVSTVRFTPDGEKLVSASRDKTIRVWEVASGYCVRTFTGHAEWVRQVVPSDDGRWLVSCSNDQTSRIWDFSNGETKMELRGHEHVVECAEFAPVSAYTAIRELAGLTSTAGDTRAKSPGAFVATGSRDKSIMLWDAQTGQCLRTFNGHDNWIRALVFHPTGKYLLSASDDKTIKIWDLTTGRCVKTVEAHGHFVTCMAWGRATLGGGTEGVNGDAKVNGEATKTEVRRINVLATGSVDQTVKIWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B363</accession>
    <name>A0A1Y2B363_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_533050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B363"/>
    <dbReference type="STRING" id="71784.A0A1Y2B363"/>
    <dbReference type="InParanoid" id="A0A1Y2B363"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="5">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="242" mass="26265" checksum="6E61CB48B91DAF25" modified="2017-08-30" version="1">MATPDDFRASSEWLSSTPAAASLPNDTKLELYGIFKFVSASAGPSGARPSIFSVAARAKYDAWAAQTARYAKLNDGAQQARGRYVGIAKEVGWKGEGLDMLKDEDDDLDLEHLSDDDEADTAPRRFKGKGRADGMGIRVSQMARPEGEAEQDGGSDYPIHDAIIDESIDEVRRLLDRDPSLINARDAYGNTPLHLAADRGHIAIALVLLEAGADRNLTDEDGQTPLQLAELTKRDDIVLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B395</accession>
    <name>A0A1Y2B395_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_181143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B395"/>
    <dbReference type="STRING" id="71784.A0A1Y2B395"/>
    <dbReference type="InParanoid" id="A0A1Y2B395"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="545" mass="60564" checksum="7D9392AC84819235" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3M7</accession>
    <name>A0A1Y2B3M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_532392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3M7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3M7"/>
    <dbReference type="InParanoid" id="A0A1Y2B3M7"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="571" mass="62437" checksum="6FB649F58D6F820C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3W4</accession>
    <name>A0A1Y2B3W4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_533800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3W4"/>
    <dbReference type="InParanoid" id="A0A1Y2B3W4"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1284"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2603"/>
            <end position="2625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2678" mass="292833" checksum="672AA2644D874C5E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3X1</accession>
    <name>A0A1Y2B3X1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_531976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3X1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3X1"/>
    <dbReference type="InParanoid" id="A0A1Y2B3X1"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="683"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="889" mass="98838" checksum="41D6BB9C3098EFFB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4F8</accession>
    <name>A0A1Y2B4F8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_481995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4F8"/>
    <dbReference type="InParanoid" id="A0A1Y2B4F8"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="532" mass="59614" checksum="3C650966EC2B33CF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B587</accession>
    <name>A0A1Y2B587_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_530536</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B587"/>
    <dbReference type="FunCoup" id="A0A1Y2B587">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B587"/>
    <dbReference type="InParanoid" id="A0A1Y2B587"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="330"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY29998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="731" mass="80902" checksum="21AAC4BE5D3BBBDF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5H8</accession>
    <name>A0A1Y2B5H8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_530449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5H8"/>
    <dbReference type="FunCoup" id="A0A1Y2B5H8">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5H8"/>
    <dbReference type="InParanoid" id="A0A1Y2B5H8"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF647">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="374" mass="40382" checksum="A4BBB9BFC3986728" modified="2017-08-30" version="1">MSDVKNEAWQYTTRGRLSTTIQLTQRPYPTYGEEDIVVEIRAAAVNPVEEQIAQLPDLMLRLGGAPPMGTPFIPSQDFSGVVHAAGLKSPWKVGDEVCGLKLDLSGEGTLQRYLRVPPSIPVIRKPSSLSFTEAAAMPLVYQTVYTALVSYGRLPFEPSPEDTGKRSVLILGGSSGTGSVAVMMAKQMGCKVVASCSGKNADFVKSLGADEIIDYRTEHVAEKAIASEHAPYAVVFDCVGGKDLIPYLNRLVLSDPKAPKLGIFVTIVGDKTDPDVLGGSVSNLTYPSQVLRHIRGALTDLLPNWLPCKSWIAGKRYACISLDQKTSYLDTIPVFLQRGGKVIIDSTFPFAEAKEAFAKLESSRAVGKVVVEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5W1</accession>
    <name>A0A1Y2B5W1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial low temperature requirement A protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_494822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5W1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5W1"/>
    <dbReference type="InParanoid" id="A0A1Y2B5W1"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="576" mass="65257" checksum="6DEE6C8FE5BE5C03" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B618</accession>
    <name>A0A1Y2B618_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_529803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B618"/>
    <dbReference type="STRING" id="71784.A0A1Y2B618"/>
    <dbReference type="InParanoid" id="A0A1Y2B618"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="546" mass="58529" checksum="8140E1244D332BE3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6Q7</accession>
    <name>A0A1Y2B6Q7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_154220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6Q7"/>
    <dbReference type="FunCoup" id="A0A1Y2B6Q7">
        <property type="interactions" value="703"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6Q7"/>
    <dbReference type="InParanoid" id="A0A1Y2B6Q7"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="241"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY30220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="515" mass="58504" checksum="95BD523880647B30" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6Z1</accession>
    <name>A0A1Y2B6Z1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_588023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6Z1"/>
    <dbReference type="InParanoid" id="A0A1Y2B6Z1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY30237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="153" mass="17056" checksum="83BDB6F45130EB80" modified="2017-08-30" version="1">MGFMPLKTIRSILPFRKNTKYDSDPVTALSVRTKSKAYKSDSKTEAWTALVNVFRGEAGGNRRYSRYSWARTDPGSLASLLDRRNTQKATTAAQSLRTYLKEDGRHHLAAAVRSFMSFSNVDDDTIQTIEQSLQTQAQEQTNTVPVVTSAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7E9</accession>
    <name>A0A1Y2B7E9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_104868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7E9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7E9"/>
    <dbReference type="InParanoid" id="A0A1Y2B7E9"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY30769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="652" mass="73121" checksum="4D1657EB2D949ACD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7G9</accession>
    <name>A0A1Y2B7G9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_528330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7G9"/>
    <dbReference type="FunCoup" id="A0A1Y2B7G9">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B7G9"/>
    <dbReference type="InParanoid" id="A0A1Y2B7G9"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="460" mass="49041" checksum="95C065A302C7078E" modified="2017-08-30" version="1">MDPTKAQTTTAFAHLKSQKANKACFDCGAKNPTWTSVTFGIYLCLDCSSVHRNLGVHISFVRSTNLDTWSLAQLRQLKVGGNASLAEFFTKHGGSSLLPPGNHDARTRYTSRQAGLYKEELAKRVRQDAERYPSGIHIDGLELTPLASPAKADASEDFFDSWDKKPVSKPASPAPPAASGPPGIGNRPSPATTSSAPRTVTSSSLRAQPSSRPAPASRLSGATAVGGKVSKLGAKKAATSINFEEAQRKAMEEEERVKRLGYDKQREEEEARAVREREAAERKSASSLGASRSSTPANGSAKVVEKVAPTRLGFGQTAGSAQPTVTKTRAVQVDDQYVAREKFGNQKAISSDQYFGRGTYDPASSAEAQQRLQNFQGATAISSNAYFGRPDEDENDDPVLSGGDGVLGGLGDNETIQGLERGMRDLAGRVMGSQEVQNLAEGVRAGAMKLSDFLSSLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7H6</accession>
    <name>A0A1Y2B7H6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7H6"/>
    <dbReference type="InParanoid" id="A0A1Y2B7H6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="246" mass="26402" checksum="21EDA094BB3EDCD7" modified="2017-08-30" version="1">MSYPSSLSTGSSPAATRSSLAPADRNSRSTAPTTDHEPTSPDGSGDNNTSGELDMFATQGDEQLYTGTSVPNIIGDSSTLDSEGPMAAASSDPTDWSLDLELLRVIEEYEIPRTLDPQDSLPPHVSYQDMVSRQEAFMDSVIEGIRTLNDQIRQGEMGPGEEENMATWESNVRKMQEELDASHQIAAKLDKTPTTLSSVELPEATHETSSLLRSVVFAVSIVAGALIFAKSRTSNTSATADRSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8Y0</accession>
    <name>A0A1Y2B8Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_526955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8Y0"/>
    <dbReference type="InParanoid" id="A0A1Y2B8Y0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="90" mass="10232" checksum="E3AFAA25B81A814D" modified="2017-08-30" version="1">MSMLPYSIISRLSVLHRARRANSYQGEWERCHRFASAGWRFGAESLGVDLLLGILSYILPCLLWKRQLSHVILPVGKAVVTSRIGCYWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8Z9</accession>
    <name>A0A1Y2B8Z9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_527383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8Z9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8Z9"/>
    <dbReference type="InParanoid" id="A0A1Y2B8Z9"/>
    <dbReference type="OrthoDB" id="2575964at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="513" mass="56276" checksum="6E20C69693496DCE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B943</accession>
    <name>A0A1Y2B943_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_527243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B943"/>
    <dbReference type="STRING" id="71784.A0A1Y2B943"/>
    <dbReference type="InParanoid" id="A0A1Y2B943"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="10">
        <location>
            <begin position="195"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="9">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="9">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="9">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY31274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="306" mass="32440" checksum="6A4CB159C922FAB3" modified="2017-08-30" version="1">MTIANGSYGPITTAQVVLGSMERAEEYQQVLTDLKLNAGHGHVQGEMVDRVLDNATSLPAPPLTIHLVLPLPLPSTLLSRIPPSTQLFVHVPPSADPSSVTALHAQLSDATFTPLLPTPSSTIIAYTSPSSGVSVPVPTSSTSARPLALKRKTTDKAKRAAIWALDSPLLPDGGRSLLTPEDKQRPECILPSADGKPVKRRRACKDCTCGLAELEAAEAQQAAAAVQEAQRAFFLEGDDDIPEHLKTATTGTEGVWPVEKRAEAKKTSSCGSCYLGDAFRCSSCPYLGLPPFKPGEKVELSIADDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B973</accession>
    <name>A0A1Y2B973_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_480017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B973"/>
    <dbReference type="InParanoid" id="A0A1Y2B973"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="235" mass="24922" checksum="8BAC43549FEC503E" modified="2017-08-30" version="1">MTTSITDARFTSLHFTPGHLASVSFDEPPETGWGVMPGYDESLPIPPHLEPPGLDADETLPSQIHPSYPFGRPPTISRPQRPWMSGPTNLLGTVGQGMKAGDGGISHWARGEIWDELGLGQVVEPEEKREVPPGMAGAKRPPSPPSPALHPTAAPAIRSQHLQRLYDRQRQTTPTAPADPFDAPVPNETYADEDVQQQNAAARGEATGQVGGARQGADDEDGDGEMGDAAGDMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9C5</accession>
    <name>A0A1Y2B9C5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_526789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9C5"/>
    <dbReference type="FunCoup" id="A0A1Y2B9C5">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9C5"/>
    <dbReference type="InParanoid" id="A0A1Y2B9C5"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="119" mass="12763" checksum="65897ACC5D6C8DB1" modified="2017-08-30" version="1">MSSSSAQTLRQLTIKTGVVKRLYKEEGSYIAEVKEAEERLNRLKAAGADGADIRNAERVVKDTEQMVPRTRKSLQEALQALEDLVAGLASEAEVTGSKEYETAVAVVNEVQAAGVANGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9I5</accession>
    <name>A0A1Y2B9I5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_526269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9I5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9I5"/>
    <dbReference type="InParanoid" id="A0A1Y2B9I5"/>
    <dbReference type="OrthoDB" id="3366659at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="294" mass="32581" checksum="DFD6EA475781CCEE" modified="2017-08-30" version="1">MSTTITTQNQGSPSSTTLKWPIDTDALYRTFKVSAAATTIGGIAGASIGFGSHANPYQYGGRMAVRYGLISLVFMGSREYLISPSLLRWQPTDGYTRRFNIMSAKALGKLPEGKETVVTFHDLRWNRVLDSATAGSLTAAGASFFIRQSVPFRAAFTGALVFSILQLTGNHMRILRLYLLGTFTDPQPSSSSIPTSTTSTSTTKVQSQDQRRLDLIAPQKTVDEYGHDTSTGQGSFSARLLNFMSYFSPLTPITDQEYLDKLEKRQNIIQVRLRGIEKEEQWLFEKSQEKSKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA88</accession>
    <name>A0A1Y2BA88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_79244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA88"/>
    <dbReference type="InParanoid" id="A0A1Y2BA88"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="250" mass="26949" checksum="6CFF4836F43288AA" modified="2017-08-30" version="1">MLPPSTNDSSTQPTHALHINTDFAKRPSSGESNSAGSSATFLATEESAPVALDRLGSPELQDRSDDCDNWNGSTAVTTPLSPYTPAGSLGKRSGLHLNNQEISDLYSGLNAALTRNTEESAASSEQLIPRPISSFWLPSDTDHDDRSSSGHLGVGDETKPETRWSPMTKIRSFFSVMGKTQVKRRIGTSNQESQQTNKPSLPSLLEITGQELSEAKEEAVLLQDLSDSLARPFFGRLTKPVTLAMTVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAA3</accession>
    <name>A0A1Y2BAA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_571331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAA3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAA3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAA3"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="166" mass="18680" checksum="6F4879289ABC7541" modified="2017-08-30" version="1">MPDTESHVKRGHPIFFGLLCFFAIIEGCITAWLVAKFNDSNDYPSHSVRDRLRFLVFTSWWTVFFTIFYIVFFFTASASIVASIASHAVWMFITWVFWLAAIASYTSALGGGQRCSHSDLTYCSQLVAAEAFGWIEWILLTIAFIFVILLGVGAIRRGDRLSAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAE2</accession>
    <name>A0A1Y2BAE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_525554</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAE2"/>
    <dbReference type="FunCoup" id="A0A1Y2BAE2">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAE2"/>
    <dbReference type="InParanoid" id="A0A1Y2BAE2"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY31822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="433" mass="46787" checksum="D297452CE8625B3C" modified="2017-08-30" version="1">MAALRTALPRLAPRLARHATVARAALPQLAARTYSNTKSPQPMRDAMTGEIIQLPDIDPSLLKIENTNTPKTRPPSSKLIFGRTFTDHMLAIPWSSATGWGTPVIKPYGPLELDPSSTVFHYAFTLFEGMKAYCQEDGTVRLFRPDMNMKRMNRSASRLALPTFDGDALEELIKRLVVLDSEWIPKEKGYSLYIRPTLIGTQRGLGVGPSSDALLFVICSPVGPYYATGFKPVSLLATTKYVRAWQGGTGSYKLGVNYAPGVVPQADAAKQGYGQNLWLAGEDDTLTEVGTMNLFVAFKLPDGSTELATPPLDDVILPGVTRDSVLELVKSHAAGNAIPGLPTNIKLSERKVVMAELVEAEKNGTLLEVFGTGTAAIVSAVDKIGYKGRDIQIPTGPTGLGSIAKALLDRIQGIQTGEIEHEWSVIANEVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAV7</accession>
    <name>A0A1Y2BAV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_526956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAV7"/>
    <dbReference type="InParanoid" id="A0A1Y2BAV7"/>
    <dbReference type="OrthoDB" id="2581585at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050744">
        <property type="entry name" value="AI-2_Isomerase_LsrG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33336:SF3">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33336">
        <property type="entry name" value="QUINOL MONOOXYGENASE YGIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="82" mass="9187" checksum="CFF9582887ED1AD1" modified="2017-08-30" version="1">MAYIQLVTIHAKPGSASKIVDHLKKIRVESLNDEPGTKIYETAQDPNDENLIVIWEEYDSEAARDEHRKGKAYGCTSLIQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBU6</accession>
    <name>A0A1Y2BBU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="6">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_523481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBU6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBU6"/>
    <dbReference type="InParanoid" id="A0A1Y2BBU6"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000634">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="201"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="516" mass="56955" checksum="9733177B60AA0023" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC72</accession>
    <name>A0A1Y2BC72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC72"/>
    <dbReference type="InParanoid" id="A0A1Y2BC72"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="250" mass="25651" checksum="1E5986DD59108162" modified="2017-08-30" version="1">MVTLTLSQLQALRRQQEIEARTAYEKKMHADQSIRAMQLAGANGQGFAPHTPQMIQSDALSPANAVSASPRNTTAAQAMQRAQSKGGAMLPPQSPASSMQRISTPKPGKMPTPKMTAKDELREAATPKSVLPSPSNAQIPIPATDPPANATGLTPSPPSGSAATPNPGSGPAGSTDSQAAANPGSVPSLSASSNSLSFATTDLSTDFGSSLLNDNDFDFASLTNDVNFDSWLAFAGMDEGDGDGEVGMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCI2</accession>
    <name>A0A1Y2BCI2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_525399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCI2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCI2"/>
    <dbReference type="InParanoid" id="A0A1Y2BCI2"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="175" mass="20033" checksum="793057EE15B4077A" modified="2017-08-30" version="1">MTQTHILRHYDTPVTGLGGHTLFLQPHIAWDWVMMPRLDIIEPSTGFLSFGPYITQTEGKDATGNVFPRLKDIYSSFRMDLSPPHAVLATWAGQFVVSRKRILDNKRQTYQNLWNKFHAPTEHWIWKEGWWNNEPSNPTLGHALERSWPVIFACEDASIAETCGEGHGPTCQCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCP6</accession>
    <name>A0A1Y2BCP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_379626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCP6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCP6"/>
    <dbReference type="InParanoid" id="A0A1Y2BCP6"/>
    <dbReference type="OrthoDB" id="2560920at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012847394" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="233"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="302" mass="32229" checksum="ABEC1F940D9E78DF" modified="2017-08-30" version="1">MYTLTATLVTLAILSLVSAQTFAPAYEGCILAADVPSGDSTGAQSSGSTCASSCSTTYAYFLTSGSDCICTDTAPVATWYTTSASSAGGCASTSDYQVYKVSSTFVFQACLSNFHDDLGLKHDNEGSQTSFEACLAYCDISGAAFVAPLTNGEWDCWCETSYTPLAYNTCGPSDPQVGNYFAYTHDLPSASGLTRRRQRRSVQEQLRLSRLEALRRPCPGEMEACLIPGSDSFECIDPKTELESCGGCQTGYWDKTRIDALGTDCTLIPGVLSDAVTCLNASCHAYRCEPGWRLVDGDCIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCY4</accession>
    <name>A0A1Y2BCY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Raptor N-terminal caspase like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_524733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCY4"/>
    <dbReference type="InParanoid" id="A0A1Y2BCY4"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="3">
        <location>
            <begin position="84"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1311" mass="144422" checksum="E1A92E628EB8830F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDG9</accession>
    <name>A0A1Y2BDG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_522295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDG9"/>
    <dbReference type="FunCoup" id="A0A1Y2BDG9">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDG9"/>
    <dbReference type="InParanoid" id="A0A1Y2BDG9"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY32889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="437" mass="46424" checksum="2ECE68AC5177F23D" modified="2017-08-30" version="1">MSADKNVVIIGTGIFGTSTALYMLEKGGYNVTMLDKCGILPAPDAASTDLNKIVRAGDYADPAYAQLAIDAVELWKKPEWDGCYHESGVICLSSPDKPEGAQFVKSAFTNLKAASIDATLVPDTASIKSHFEPSIPTGSFGSRQGYSNPVGGWAEAGRAVEVGLARVRQLGGTIRAGAEVVALQVGGDGKTVEAVTLEGGEDISCDLLVCAAGAWTPKLFASSGIAARSPPVNATGQSVATVQLTPEEMETYSKVPVVFNLDDGFYVFPPNPQGLVKFAIHAAGYTNSSPDSNGVSVPRTKLTPGAEDGMIPLEKLQKLRAGLAEVYPELAKKDLVSTRLCWYCDTISGDWLIDYHPDYTNLVLATGGSGHAFKYYPIIGREILKVIEHDPPKEFAHRWSFGYDGADAGADVRVDTVKELKLDDLASADDLRVSVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE85</accession>
    <name>A0A1Y2BE85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase superfamily domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE85"/>
    <dbReference type="InParanoid" id="A0A1Y2BE85"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF35">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="424" mass="48502" checksum="38567DBD21CA7CB0" modified="2017-08-30" version="1">MSSTGLFTVRRVVFGLPVIWTGAWLTYYAYTDTIRRSHIRNRNRTLSETLARLSGGEVDYNRPATELEKEALKKRFASLRFAGRYWNPYVEWREQGAWEWAVWKIVLSTMSLKLFYNGGVPTERPIPDLPIERPDFELLFGAKQGAQKEQVNVTDRMTITWLGQSTSYVTMDNLAILTDPALSERTLESWVAPTRLRPPPCRLDELKRVDVVLVSHNHFDHLDPAVIKELGDTCEWIVPIGVGDFMRKQGVNRVTELDWWKDTKFTLKGGEKGDKTFTITSVPLMHWSARSPKDTNATLWSGFHVRSDSDRPRSFIHLGDTGFSPTLFHAVGRVFGPIDLAAIPIGSYEPRWHLRQQHTDPEGAVGMAMLMNVRKSVGVHWGTWLMSDEAYNQPPKDLEIARKKYEIDQDRFCVLPVGKTIVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BET5</accession>
    <name>A0A1Y2BET5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_463616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BET5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BET5"/>
    <dbReference type="InParanoid" id="A0A1Y2BET5"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="207" mass="22050" checksum="515F1FC84B508F8B" modified="2017-08-30" version="1">MSSSSASRSSSSGSVNANASSTTSSISIPGTAAAGGLTVTQPPSTASASYFKIAEHEFITFGWNLTSLYVTPQHLTIIASCSANGNTYPVGPTASPSNTIPANQTQIIWNPHEWEQIPGQTPFAEATYVLKIWDERGPGVGVKGGFFSPYAGTDFMMYRPEQYTSIADGWKCTTCSNAFNHLSEPTGLALVTSFLIMLFSAWNILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEV7</accession>
    <name>A0A1Y2BEV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_519493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEV7"/>
    <dbReference type="FunCoup" id="A0A1Y2BEV7">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEV7"/>
    <dbReference type="InParanoid" id="A0A1Y2BEV7"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartokinase ACT" evidence="9">
        <location>
            <begin position="504"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY33373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="578" mass="62813" checksum="1E37C77FAAE9874D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEY8</accession>
    <name>A0A1Y2BEY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase like family 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_519830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEY8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BEY8"/>
    <dbReference type="InParanoid" id="A0A1Y2BEY8"/>
    <dbReference type="OrthoDB" id="2849215at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="445" mass="51054" checksum="1686BEC2B273B0CE" modified="2017-08-30" version="1">MLYLTADKFPVFVPFGVIGFYRYLWFIIRLLARWAYRPIPLPENPTYVASEDVTIIVPTIDAGEEFREAAFSWLEGSPKEIIIVTEDKMQGPLQELANSVDPSRIRVLTVPFANKRLQMAHGIRNTTTDIIVFADDDAIWPATLLPYVLACFEDQQIGGVGTSQRVKPCGDRMTLWEVLAAFRLTIRNIEIASSTHIDGGIPCLSGRTAAYRTVILKDPDFLHGFTNDLWLGKYHLNSGDDKFLTRWMVSHGWNTYVQVCEQAELLSTMKPNWRFLKQVLRWTRNTWRSDFRSIFTERYIWIKHPYVAYTMIDKFINPLTLLVGPVLVIYLIVKSTRDVDDGGYHLAAWKIIISYAVWLTATRAAKLIPHLWYRPAHIIYVPAWILFGYYFAIMKLYALFTLHKTGWGTRAGIGDPATATAAQEKSDAQRPREIYDVEMNGARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF79</accession>
    <name>A0A1Y2BF79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_520364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF79"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF79"/>
    <dbReference type="InParanoid" id="A0A1Y2BF79"/>
    <dbReference type="OrthoDB" id="2563380at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="420" mass="47643" checksum="9AE353236DAD248B" modified="2017-08-30" version="1">MAEDRSDTEDASVENQIPAGKRKRVVLSCLNCKKRKVKCDKQLPCINCRERREIHLCRYGSTPPASESYVKLSLFTTLQDRVRQIEQHIFRSVSTDTVTPSSLTSVRPSTTKDETHTSKSESAFLALDDLSNVTNDPDETHGMRLFHKPPRPRAQQPSGVWPNIVGQIPVNERPDRWIGAMKDNLAALPDRPVMEHLVDHYFSTVDLFWHHVHQSVFREEFSQFLSIRDSGQPLLVDPAWIALLTSVLCVSTHSLLRCGWTNGLATLNDTHRDFYNSLSKQLDEAFENVLLCAGCLRRPQFRVLQALLIILNINQMDRPMSSFDGVLCEPTASLWLDTAISICQGLRLHMLGPQYERDTPPDPAFPSGQTLYAQEMASRATHALAFWDQIICCLEMDERGGDQWAFRFPTGGCKKTIDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFZ0</accession>
    <name>A0A1Y2BFZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_518957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFZ0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFZ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BFZ0"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="90"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="608" mass="64296" checksum="7D928644AB3836BA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHR3</accession>
    <name>A0A1Y2BHR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_596975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHR3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHR3"/>
    <dbReference type="InParanoid" id="A0A1Y2BHR3"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="565"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1058" mass="114745" checksum="64BD80B467257A5A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIM9</accession>
    <name>A0A1Y2BIM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_513825</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIM9"/>
    <dbReference type="FunCoup" id="A0A1Y2BIM9">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIM9"/>
    <dbReference type="InParanoid" id="A0A1Y2BIM9"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="482" mass="51819" checksum="F56D9A9FCFE203E7" modified="2017-08-30" version="1">MLRSRSAASSARHVCSLHRPISSSATFPCTRSHSTTSASSEPRISSRKSSAWAHATESAHSVLPPPQFDALDPLSAINAEIGDLKSSLFQLLGSSHPSLDTVAKYYFQAEGKHLRPLIVLLMAQATNGLGGAGWEEARMDARRNNVDDSLTRDGGVLNDWNPEQSGPEPQGAMIFAEPFQIPTSSSSSSSRIRPPLPPALPPLDTFSGNEILPTQRRLASITEMIHVASLLHDDVIDTSPLRRGSPSAPSAFGNKLSILSGDFLLGRASVALARLGSREVVELLATVIANLVEGEVLQLRATSAPETTPSRKGFEEYMRKTYLKTASLMAKSARASVILGGCGTGPTKQGEWVKDVAYGYGRNLGIAFQLIDDALDYLPDSSTLGKPSSGADLRLGLATAPALFAWESNPALGPLILRKFEEPGDVEIAKDMVARSNGLERTIELARKFAGEATRCIERLPTESEATEQLKRLTEKVVERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIV3</accession>
    <name>A0A1Y2BIV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_514112</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIV3"/>
    <dbReference type="FunCoup" id="A0A1Y2BIV3">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIV3"/>
    <dbReference type="InParanoid" id="A0A1Y2BIV3"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="131"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="236"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="469"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY34713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="618" mass="68533" checksum="F8395A9449B90E74" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ34</accession>
    <name>A0A1Y2BJ34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_518540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ34"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ34"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ34"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="712"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="241"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="448"/>
        </location>
    </feature>
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        <location>
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            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="659"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="831" mass="83117" checksum="E5B2A49EA3850453" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ91</accession>
    <name>A0A1Y2BJ91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polysaccharide lyase 14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_513823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ91"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ91"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ91"/>
    <dbReference type="OrthoDB" id="3337916at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
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    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012056276" description="Polysaccharide lyase 14 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="3">
        <location>
            <begin position="225"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="446" mass="46242" checksum="5F43C676449F771D" modified="2017-08-30" version="1">MLFTQPTTTLFLLLSTLIAAPISLAAVPEKGHPRSATHLVHARDSPARHFERGTKHTPKQSLVRRKKKRSSGCQVAVSVSVPESVSSTAAVPGETLIVSPSASGSDSISAISSASSSVDVVPTASSADVSLSSSSPSSSSLDASPTSSASTETSIISSQTSSTSSSAPAATSAASSGMLARLFPVASIESSWTTSTESSSALSISSALNPVLSGKLPAIGTAPDGSTAIVADFPAGTAKLASGQGFNFYSAGDKSGVDVTTAREVLLSYSAFFQDGFEPNKGGKMPGVFGGTSLAEAKSCSGGRQDERDACFSARMMWRTNSMGELYNYLPNTVTPDYCTDGQGGTYCNSDYGDSVGRGSFTWTSGEWTTVAMRIKLNDGSQANGEQQLWVNGESVLNLSGLVFGTSETKIYGIMAQTFFGGSDDTWASPIDQKIWFKDWSLAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJA3</accession>
    <name>A0A1Y2BJA3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_461906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJA3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJA3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJA3"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="46"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="183" mass="19333" checksum="1F13EE74A798BCF0" modified="2017-08-30" version="1">MKTSSASSKPPTSSSTSKSTSKSTSSRKTTSSTASASPSPSTGLTTDQQNFLDLHNSFRPHYGAATVTWNSTLASYAASAAKTCVYGHTHGPYGENIAAGVGGGYDLTAGFHSWSDESQKYNYSDPGYSDATGHFTQIVWKATTQIGCAAQKCADGTIFTGYGQDSLYLVCKCFRTLFGHRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJJ8</accession>
    <name>A0A1Y2BJJ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Organic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_194622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJJ8"/>
    <dbReference type="FunCoup" id="A0A1Y2BJJ8">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BJJ8"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="195"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="288" mass="31188" checksum="2DE4D356EFCBB2CE" modified="2017-08-30" version="1">MSDLKKPVPLPFGYTFLSGAIAGCTELLLLYPLDVVKTRQQLHTGKGGVGMMATFRSIVATEGASRLYRGIVPPLMLEAPKRAVKFGANGYWGNLITSNGQRKNTQLLATLTGCAAGATESVVVTPFELVKIRLQDKSSTFAGPLDVIRHSLKTSGPLGLYQGMESTFWRHFWWNGGYFGAIFWVKSLLPKPERGEILNNLAAGTVGGFVGTSLNTPFDVVKTRIQLKGTGEWAYPALFKIAKQEGFSGLYKGFAPKVLRLAPGGGVLLLVVEALSTVFRNYLGPPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJW4</accession>
    <name>A0A1Y2BJW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJW4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJW4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJW4"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="346" mass="40031" checksum="152E880C45E9FF9B" modified="2017-08-30" version="1">MGSHRHRADSRSPKRHRDSHDRHRERDRHHRKSKGERAEYSDEGESARKSRRKRRESRDDDHDEEDEGERRRRKRRNLTPEDDEDLLDLRKLGVAEITEDDYFKKSAEFKVWLKESRDKYLDEVSSESAHKYFRKFVRRWNDGALPKHIYLSSSIDPSSNTAYKWGFASSAGSQRHRSPSEDSQEPIGPTLSPPRHASSSRKRPLGPSLPSASDRQLAIEADVDARKAARKAELKDRYQKADEAVPRERGKEGKMDEKRATNASNKEMREKDVVGLEVDEGTLMGETDGFAAALRARDSAESRRADRRAAFMAERRVVEEERLSERKAKEAATMDMFKALAKQRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKM6</accession>
    <name>A0A1Y2BKM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_591866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKM6"/>
    <dbReference type="InParanoid" id="A0A1Y2BKM6"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37154" checksum="2B33E51FAC146F0D" modified="2017-08-30" version="1">MPIAVPVEKASPGFGDWRDELVTKGYTVVKGAVPRERALEYRDRAFQWLEGFPLGFDRNDVSTWKNEHLPVHVKGGMFHGYGFCHEEFLWDLRCEDGIIDAFAKVWGTDELITSFDGGSIMLPKRTDVKDGGKWEHMDQSLHRRGFYCCQGLVNLNDCGPEDGGLMVLEGSNKLVEEHFDIHGRESYKTWGPFDWYGFTEEQQQWFYDRGCKWTKVCAEPGDLILWDSRTMHYNVRPSGERDRVCTYICMAPASLLSDEDRIQRAECFANYRGTTHVPFAAVFSRAHEPVVRHDGKPCPHDTGVPRNLPKKSLKVLRLVGIEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKP7</accession>
    <name>A0A1Y2BKP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_508811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKP7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKP7"/>
    <dbReference type="InParanoid" id="A0A1Y2BKP7"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF83">
        <property type="entry name" value="K+ POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="264"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY35332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="433" mass="47404" checksum="2777C36CD0EC9D5A" modified="2017-08-30" version="1">MLILAYLGQGACLITKPSVISSIFYLTIPGDTGGALYWVVFVFAILATLIASQAMITATFSLVHQLIGMRAFPAMRIKHTSNLTAGQVYIAPINWLMMVGTIAVVGGFGSSGSLTLAYGFAVATVLFVTTTLIALSISYVKHLTFLLGIAFLIFFGFLDGLFWGASLKKVPHGAWFPLGLGGLLCILIVFWSWCRQLEDTFDDANTQKLSQVISAASSFQHEEFEIGDTRHPSPTPGTSTPNGELYLRKRHGSSDTPLAKIPVMAIFHRNDSTGRGVPHSFASFLQRYPALPAVVIFLTTRVVGVPHVPEEDKYVVNKVRSFDGFYSVTMRNGYHDRTPPSIPTFLPSLISLAAQSGSPSQVETLQAISSDVTHVIPSYEILSAKSRFKPWSWVRKILVEDLYGRARVIFPDWSNSPGPEENNMIHVSVAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKS2</accession>
    <name>A0A1Y2BKS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_555521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKS2"/>
    <dbReference type="InParanoid" id="A0A1Y2BKS2"/>
    <dbReference type="OrthoDB" id="2563880at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="610" mass="65027" checksum="8EDECD8C549EC5FB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL50</accession>
    <name>A0A1Y2BL50_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_510099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL50"/>
    <dbReference type="FunCoup" id="A0A1Y2BL50">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL50"/>
    <dbReference type="InParanoid" id="A0A1Y2BL50"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="197" mass="21761" checksum="F81624841BF83385" modified="2017-08-30" version="1">MSHTHEATEDDLNPTQTEGYKVGQSRTVAELAALDQEDESLQRWKQSLGIGAATGGGVKKVILKTLFLSSPTLTQPISIDLTQPAAELSKLKKEPVTIKEGVEYSVGITFVIENEIISGLKYLQVVKRSGLKVDKTEAMLGSYGPQPEPYTKIFASEESPSGMLARSGSYNVRSRVIDDDNHVWLDFEWGFKLAKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLC1</accession>
    <name>A0A1Y2BLC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_475390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLC1"/>
    <dbReference type="FunCoup" id="A0A1Y2BLC1">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLC1"/>
    <dbReference type="InParanoid" id="A0A1Y2BLC1"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="148" mass="16769" checksum="813510E0A1FBDC67" modified="2017-08-30" version="1">MSLPKRILKETERLMADSPPGITAAPKDDNLRHFDVTVAGPGQSPYEGGIFKLELFLPEEYPMNPPKVRFLTRIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSIQALLGAPNPDDPLANDVAQHWKENEKAAIETAREWTRKYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLJ4</accession>
    <name>A0A1Y2BLJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_510427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLJ4"/>
    <dbReference type="FunCoup" id="A0A1Y2BLJ4">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BLJ4"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000905">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="199"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="381"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="749" mass="84310" checksum="7C6F190151658FE6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLS9</accession>
    <name>A0A1Y2BLS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_511809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLS9"/>
    <dbReference type="FunCoup" id="A0A1Y2BLS9">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLS9"/>
    <dbReference type="InParanoid" id="A0A1Y2BLS9"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="118"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="521"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="8">
        <location>
            <begin position="695"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="786"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="834" mass="92219" checksum="F710D2F8E2A43182" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM09</accession>
    <name>A0A1Y2BM09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_511973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM09"/>
    <dbReference type="FunCoup" id="A0A1Y2BM09">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM09"/>
    <dbReference type="InParanoid" id="A0A1Y2BM09"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="8">
        <location>
            <begin position="373"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="467" mass="52480" checksum="78FEFCE9144ABA2E" modified="2017-08-30" version="1">MDSQAEFSKRKLWGGRFTGTTDPLMHKFNASINFTKTLYKVDVRQSIAYSKALAKAGILTDAEAKEMERGLKIVEQEWDEGQFDIKADDEDIFTANERRLSEIIGTGIGGKIHTGRSRNDQTATDARLWLIDQIKDIKTYLIDLISVMTNRAEKEVDALMPGYTHLQKAQPVRWSHWLLSHAHALLNDLERLCQLVPRISVLPLGAGAMAGNPYELDRAFLAKELGFQSVGQNSMHMVFDRDFVMEFLQWSSLLTNHFSRLAEDLIIYSSGEFGFVQLSDAYSTGSSIMPQKKNPDSLELLRGKSGRVFGQMAGLMMSMKGIPTTYNKDMQEDKEPMFNCASTVQDCIRIAEGVIATLDINPEKMRAALTEDMLATDLADYLVRKGVPFRTTHHISGRAVALAEQEKKSLSELTFEQYYSLSDKFEKDVHGVFDFESSVEKRNAIGGPSRKGIATQVEYLRTALSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM39</accession>
    <name>A0A1Y2BM39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_512422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM39"/>
    <dbReference type="FunCoup" id="A0A1Y2BM39">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM39"/>
    <dbReference type="InParanoid" id="A0A1Y2BM39"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="39"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="331" mass="34515" checksum="FCCDE953742CE03D" modified="2017-08-30" version="1">MLRNSLWSAAGVARSVGIARTFSTSAPRASYEDTIKNILINKDTKVLVQGFTGKTGTFHAQQAIDYGTVMIGGTNPKKAGTTHLGLPVFGSVREAVRETQPDASVIYVPPAGAADAIIEAIEAEIKLIVTITEGIPQRDQIRVMNALKSQSKSRMIGGNCPGIISEGCKMGIMPGHIFKQGKIGVVSRSGTLTYEAVNQTTLVGLGQSLTVGIGGDPFPGTQHIDVVKVLLDDPRTEGIVLIGEIGGSMEEDAAEYLEQYNKNGKPVVAFIAGRTAPPGRRMGHAGAIISGGKGAASDKVKALQKAGAVIAESPAQIGALMLKAMKEIGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM48</accession>
    <name>A0A1Y2BM48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_512395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM48"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM48"/>
    <dbReference type="InParanoid" id="A0A1Y2BM48"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="284"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="737" mass="79792" checksum="9BAAC5E12F5FB857" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEG0</accession>
    <name>A0A1Y2AEG0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_488782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000128">
        <property type="protein sequence ID" value="ORY20670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEG0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEG0"/>
    <dbReference type="InParanoid" id="A0A1Y2AEG0"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="323"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="653"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY20670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="837" mass="94366" checksum="B7D7DB9F7D2F07E5" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFJ7</accession>
    <name>A0A1Y2AFJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_567280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000119">
        <property type="protein sequence ID" value="ORY21037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFJ7"/>
    <dbReference type="FunCoup" id="A0A1Y2AFJ7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFJ7"/>
    <dbReference type="InParanoid" id="A0A1Y2AFJ7"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF40">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G09800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="74"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="285" mass="31201" checksum="BFCFE35687B85341" modified="2017-08-30" version="1">MSSTTVLAAASTSTTNRPSTDAVFHQSTDKLSKNPLERTWRGNKEGTLKIEAYPAFHDATDEEGLLKKRQWIKEHLAIAFRFWGKMGYGEGISGHITVRDPILTDHFWMNPFGVHFSHMSVSKLVLVTPDGYVHPLGAQRPINMAGFYIHSAIHHARPEVQAAGHCHSLHGKTWSAFGLPVDITTQDSCLFYDNQAVYRNFGGIVLAAEEGANIAQALGPKNKCCILQNHGLLTLGHTVDECAYLFSALDKQCRAQLMIEAAVGGGLKKTIISDEDAAFTAATIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFU7</accession>
    <name>A0A1Y2AFU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">deoxyhypusine synthase</fullName>
            <ecNumber evidence="7">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_553828</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000113">
        <property type="protein sequence ID" value="ORY21332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFU7"/>
    <dbReference type="FunCoup" id="A0A1Y2AFU7">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFU7"/>
    <dbReference type="InParanoid" id="A0A1Y2AFU7"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003052">
        <property type="entry name" value="PRK03971.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY21332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="38463" checksum="1B1DFA3007FA7780" modified="2017-08-30" version="1">MSDTTTAHASVLAPSQALPEDAIHVKGPDFSRPIDLQELLRSYEAIGFQATGLARAIQIVEEMRKRRSDPNEPLTLFLGYTSNLISSGLREILRFLAQYKLVDCIVTTAGGIEEDFVKCLGSTVLGEFHLDGAELRKKGLNRIGNLLVPNSNYCSFEDWVVPILDQLVAEQEGPEKTRWSPSSVIRRLGKEIDNEESVYYWCYKNDIPVFCPALTDGSLGDMIYFHTYKTEYQLNIDIVADIRRLNDMSVHAKKAGMIILGGGVCKHQIANAMLFRNGADYAVYINTGQEYDGSDSGARPDEAVSWGKIRAGAESVKVYADATLVFPLVVAATFGKAHWEAQADKQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGD9</accession>
    <name>A0A1Y2AGD9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_53869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000107">
        <property type="protein sequence ID" value="ORY21649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGD9"/>
    <dbReference type="InParanoid" id="A0A1Y2AGD9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="301" mass="33504" checksum="56588F6853AD0763" modified="2017-08-30" version="1">MDNQHNILQYIRRVAPRLIRSRPFDHLRPLTRQDYLTNYRGVQATLRPIVQEGRSFLRNVTGSTTANLLSVAKALCDSDPYLSYPTELITALTAIQRLGADGKTTRIINRPVYILESFNGLTADTMAEAARNFATAAELVRLDLGDLPQTGVWMGTLQVAGAWAVWVYRGVAEGTATLQVYDEHNEWSDHEVKLAFIDPVAQLLSGTEIERTEAAEVVGMSQVKLFEHASLESSGPLSVRIIQALIHSPDPILTSKRLLIDDPIASFDEIVLALRDLHFRCVLDATNMGTEVFDYVRSNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGK6</accession>
    <name>A0A1Y2AGK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_52238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000106">
        <property type="protein sequence ID" value="ORY21691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGK6"/>
    <dbReference type="InParanoid" id="A0A1Y2AGK6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="78"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="307" mass="34350" checksum="45C395855F8689F2" modified="2017-08-30" version="1">MLLHYPLPLSFDSCGEATTTRRIPDTLSCTATVSRVNTLASDSTVRPGHHSASVLSAAEGLRRLRSDWRLPSDLWIDGIPQIFVGFCFQLNRSLYQPGRASALAVVIQGRGGITSDTALPTLENIVVLPSRCIAKAPVLRVESEFTTVDSNWVERCCGSNTLLPFYEPEYVDLGRAEEIDEDLDLEQSNLRPREKLQLKGADRDRFDYIVSLSERYDFDRGTLKDFYNLIKDSAVRDRPKYARGTEGFIRKNKSLFYRAIPAMSARTKSDRMTTARTASSRARLESENTPPSSASLTSSLKHMRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGL0</accession>
    <name>A0A1Y2AGL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_553627</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000111">
        <property type="protein sequence ID" value="ORY21430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGL0"/>
    <dbReference type="FunCoup" id="A0A1Y2AGL0">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AGL0"/>
    <dbReference type="InParanoid" id="A0A1Y2AGL0"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY21430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="304" mass="34258" checksum="BCB7EF09B7464157" modified="2017-08-30" version="1">MAPKTRSKQATPEVAVSGVDGLPAPLGDFKSRPREGSRTRQEEVFDPKYAVDLATTTRSENVFLFVPNLIGYARVISAAAALTIMPYHPRRCTLLYFVSCILDVADGHTARALGQTSKFGAVLDMVTDRCTTACLLCFLSMKFPDYSLLFMFLITLDFSSHYIHMYSSLLTGSSSHKTVTSDVSRILWYYYNDSRTLFIFCFCNETFFVCLYLIAFLKDPIHSSWPLSFFVTAQQLHDTLPRPLWALLCLSWPQLVAIITFPLTAGKQIINVVQFWKASKILVGVDLAERQAARMARERKGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGL9</accession>
    <name>A0A1Y2AGL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_553067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000105">
        <property type="protein sequence ID" value="ORY21758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGL9"/>
    <dbReference type="FunCoup" id="A0A1Y2AGL9">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AGL9"/>
    <dbReference type="InParanoid" id="A0A1Y2AGL9"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY21758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="391" mass="42408" checksum="9B03D0EDEB576084" modified="2017-08-30" version="1">MSEGLTRRRGAATSPAVASSERFDSAPIPSSSAAPKRPGASVPTSVAGGSGGSGAIEGRAKVAYDPRDFETSGEAEQMPRLTIMEEVLLLGLKDKAGYLSFWNDNISYALRGCILIELALRRRIAMVKDPSRRRLALADRLIEVIDDRQTGETILDEALKMMKSSEKYGTGAWVDLMSGETWNVMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPIADMNAKEDVMRRTLALLTARTAAVPPQALHKEGVKYRYMRAVVLVCAAYASSVLENALQRLSYDSREAAFARCDDILAEFCTWPFGQGTSDIAGPVNIGGGRKREGGSGGVGRESVQELVREVRKEMASSSTGGAGSGGGVEDQEDLCFEVVATVLEIFGRMDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGM9</accession>
    <name>A0A1Y2AGM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_553046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000105">
        <property type="protein sequence ID" value="ORY21753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGM9"/>
    <dbReference type="FunCoup" id="A0A1Y2AGM9">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AGM9"/>
    <dbReference type="InParanoid" id="A0A1Y2AGM9"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY21753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="209" mass="22988" checksum="467FB3264AB2DA57" modified="2017-08-30" version="1">MVSRPLARKLVVLGDGACGKTSLLTVFTKGYFPTTYEPTVFENHVEMLQVDEQTVELSLWDTAGQEDFDRLRSLSYADTHVVMICFSVDSPTSLENVETKWIEEVNEHCAGVKIILIALKCDLRDDPAVKSRLARSALSPVSYDQGLAVARAIRANRYLECSAKHNRGVQEAIYEAARVAVGTKPKGGGSTTSDRLRPSGIKKRGCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH88</accession>
    <name>A0A1Y2AH88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000101">
        <property type="protein sequence ID" value="ORY21943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH88"/>
    <dbReference type="InParanoid" id="A0A1Y2AH88"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="33533" checksum="B18450FA41E25E88" modified="2017-08-30" version="1">MLNENQEFLDPLEGDDDGLRDDVDDEEDEQQHEEDDSQNDDHEDEDSDAFDPTADGAVESTPKPASRRKVTYRPSGPSRLKPPNVRDRGDLERQAWNERKRRSRSKGLAEGPLIAKFNEDLGKLLNAHRQWHVVPHPDPKEKLVLMARWRRLGHQAERTAKELREYRNSRSRSHKLSSFFLNLPLGFCLAFSPLLCETEDDDENRQERIENRQERIDKLSLVHDLAFKYRYGCTNKQRVDWMKGKDLDWFDSAMATTVGKLEAEDEEDESDRDWREELGDCLEYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIA8</accession>
    <name>A0A1Y2AIA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_386566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000095">
        <property type="protein sequence ID" value="ORY22323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIA8"/>
    <dbReference type="InParanoid" id="A0A1Y2AIA8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="245" mass="26137" checksum="937EE2FCD9A40285" modified="2017-08-30" version="1">MASEASVSTPPLDATVDVDGFHIGTVSDLGLSPDSPTALALLPSNMLPFGFRSVQQGIECIDDHHGWGLAPNATVGYKWYPYGYSHPKFSCDRQATAGRPTIIVRVEPIEHGLHKGVALLPCWGCLLSSSADCTVKGAVARYRGPLRTRPPRVLASLTPSQTSSAPHIRTLGASTAAIEINEAGAKRLKRLHNTSPSESAAHAGEYWYSTTTATSTLVSSLGSRLKALKTKLPLVLRVLCTLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIK7</accession>
    <name>A0A1Y2AIK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_474086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000098">
        <property type="protein sequence ID" value="ORY22120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIK7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AIK7"/>
    <dbReference type="InParanoid" id="A0A1Y2AIK7"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF84">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY22120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="205" mass="22866" checksum="E53B2A40E2177772" modified="2017-08-30" version="1" fragment="single">STLLIANLGDCCLLLIRQGEVVFRTSEMQHAFNFPLQQVGTHSRDEPMKDAQRYDVGVGRGDIVILGSDGLMDNLYDEEILDTLAEFAPPSSNVFPTPPNSRPSSPGALPPFSPQKVSEALCRRARMVSEQTTATTPFMERAIEEGIDFVGGKKDGESLVVVFYLRISSMLFFCLSISVSSMSKRLMGFFSFLDRYLGPSWCYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIT9</accession>
    <name>A0A1Y2AIT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_595761</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIT9"/>
    <dbReference type="FunCoup" id="A0A1Y2AIT9">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AIT9"/>
    <dbReference type="InParanoid" id="A0A1Y2AIT9"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="249"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="583"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY22499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="670" mass="74338" checksum="8DF02CDAC8ABBFA5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ58</accession>
    <name>A0A1Y2AJ58_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_562377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000095">
        <property type="protein sequence ID" value="ORY22330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ58"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ58"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="242" mass="25756" checksum="1FDB7F0D8EC295E1" modified="2017-08-30" version="1">MTPFGLRPTLRSHRLLTEETIRAPVARHSLTPPMLPWGSHVHQNAHKRGYIAPNGGGLCLEVAGYRNSSNIIYVVDNIGLEYRCDNTIFDVYSGRALCSCSGPYNLTSYPGLFGQVQTDPCSAAGLTAGLPPSTASTASSTASSTSTTLPAVATSPNSLQKINYVFRVMQFTVQSTANGINKSDHTSLLVSAQDGGPTTNQTLERFRYLGGVFQNSTCAYPVDSGTDLQSASGNHATPVRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKT9</accession>
    <name>A0A1Y2AKT9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_549866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKT9"/>
    <dbReference type="InParanoid" id="A0A1Y2AKT9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY23114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="58" mass="6351" checksum="CA02AD0026BB2E88" modified="2017-08-30" version="1">MALVKGLPSFLRLLPDVKARLSPGGALHDLRSGADDLCELIRGIQRRPRDENNLSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKZ8</accession>
    <name>A0A1Y2AKZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_363303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKZ8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKZ8"/>
    <dbReference type="InParanoid" id="A0A1Y2AKZ8"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="399" mass="42588" checksum="DE491180AA92F4FA" modified="2017-08-30" version="1">MSVFTREKFTMSALPTPAGSAPPSAPTSRRGSFAIPASGAMTPVTDPHIVEINVESVLFDMDGTLINSSPAVVVAWNLFAQSYTLDLEDILRSAHGMRTIDVLKKWCGISDPETLDREVIRFETAILNAAEEMAARDNKPGIEVLPGVKKLLDDLSADKDKRGGEEKWAICTSSTYFYAGKAIPIAGLTTPKVFVTADSVTRGKPFPDPYLLGAEGCHASPFESLVVEDAPTGIKAGKAAGSFVLATCTSHTREELEKERPDFLVEDLSHVTASWDPESKTFKLIIEQPVDRMTPRATPDVTPVVTPAVSRANSFSSGPGGRFAYRASDDLTGNDSVVGSPVPSRPSSPGEKGVPPPVPERRPSMTGGNMEGVTLEAFKKALAGNAAKSQRQAEANQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMA0</accession>
    <name>A0A1Y2AMA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMA0"/>
    <dbReference type="InParanoid" id="A0A1Y2AMA0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="192" mass="20285" checksum="8F28C573FA2ED512" modified="2017-08-30" version="1">MPKDKSTYSRTSHSPMPTPYARSEIGDPSQSTELPATTSMSFHLSLTLATSSSTAIHNISERSPSTDPELFGSRSSTGIESSSDRDEGGSAEEDDSRSSNPVVCIAPLQSTSTLTAGPSAFPSANTRSRSSSVEYIETRYPIAGTSSVAASASFEGANGAFSNDSIGSLRTPFWPPTCGKRTYRKITQLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMB2</accession>
    <name>A0A1Y2AMB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligosaccharyltransferase subunit Ribophorin II-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_345735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMB2"/>
    <dbReference type="FunCoup" id="A0A1Y2AMB2">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AMB2"/>
    <dbReference type="InParanoid" id="A0A1Y2AMB2"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044241902" evidence="8">
        <location>
            <begin position="25"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="189"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY23713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="294" mass="31270" checksum="454BFD7C70130F70" modified="2017-08-30" version="1">MRLVTPATLLTVLSGLLAVPSVLAGELGIKQGKISITSPNGLNDATYPLKEPTPLSFPITLTDDSTLKLSFSVVDTSSGEGVFPQQAHLLFHDPKGDDVTLPIALKSNGKASFTINGAKIPTSLAQTHGTLHLTLLLSSLSAHDPLLYPLGTLILPPTSLRLPPRKRHDLPPRAGEPAFKPEQELFHTFRQDEKTVGFVKSALGTGLVLSPWAVLAALFGKVSGELDFKSPPLSSWLFLSSLAALEALILTYWVALKLYHLLAVLIPLSLASAYAGKIALGSLREKRLKAGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMC3</accession>
    <name>A0A1Y2AMC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_346918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMC3"/>
    <dbReference type="InParanoid" id="A0A1Y2AMC3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="295" mass="32519" checksum="F4186A704700591B" modified="2017-08-30" version="1">MLIFSIVESGQSYARTFAGGELRTQRSESPVPDVIESHGWHVDSTFSAMAAEKYLRADPQQSHQAQSSSSGARRNDAKESKSAGPATTMPSATERMASSSQIPSGSRSRKRKASPAPHPDSFKQRRTAPKKHEPAAWNSSTAFGEPSTVMSEGSQGIGFDREAPRVQTVHSANNEKTDTMTQCQFRFFCPNSQSTCLVPSPIWARFDTRLTGPVVPLCPVHLPECATSIETKGRERRKWAVKHDGKRFRACVLCSCTSRSRIPHAASSLQVLDGRAWCRFSNLVEGERCLTRFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMI2</accession>
    <name>A0A1Y2AMI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ribosomal protein L27-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMI2"/>
    <dbReference type="InParanoid" id="A0A1Y2AMI2"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18557" checksum="A5A1404038AAFC4A" modified="2017-08-30" version="1">MRPSEVLLGAMRLRWTTKMGNKHYFKGTRQAFVPGEGRRTGLPGKHSVKGRGKFQIDDHLVRYYVSPGAEALANTEFKPYVHRTETTPTLQHLGTLAEYIQREQAAKRVKRLSFEAWEPKHRQALITERRRGWWNALAKKYPAAPAATDKAAESGESQVEQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMJ1</accession>
    <name>A0A1Y2AMJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_486969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMJ1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMJ1"/>
    <dbReference type="InParanoid" id="A0A1Y2AMJ1"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="138"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="313"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="415"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="770"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY23704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="873" mass="96984" checksum="9F8C3594A24D42F8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANG4</accession>
    <name>A0A1Y2ANG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_500522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANG4"/>
    <dbReference type="FunCoup" id="A0A1Y2ANG4">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANG4"/>
    <dbReference type="InParanoid" id="A0A1Y2ANG4"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="48"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY24026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="140" mass="15686" checksum="6328BD29A2DF74E3" modified="2017-08-30" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPSQAQGSGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDMALARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANS6</accession>
    <name>A0A1Y2ANS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_334496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANS6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANS6"/>
    <dbReference type="InParanoid" id="A0A1Y2ANS6"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="68"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="402" mass="44430" checksum="C5E4822721AAA9E8" modified="2017-08-30" version="1">MAPRRSVQNGTSQTQTQRRQRPVPVPVPVTSEDEISEHGSAGSSDEASTSRQNGGPRDIETKNRASQLVRLALFFEYRRRALSRMEIVKQVMPSDGRAFNAVFEAAQAVLKSTFGMELYELPKRVDRDRLGRAGAETQTQTQRGKGKGRARNDDGDDEEDDGEEDGDVEPGVTSRSRKAPGSKTYILRSILPRELIAEMSQPRPLPMLSTPNGSDDQPEDSGALIQWEKGDGTPSGHVALMGIRAVILSLVLCYGRSIDDDILHALLRRLDLDRNTLLPYTSPDSKDPPMDLDKYLDLLAKQNYLEKVKSAIPGNRDAEKISWKWGNRDAEFSEKAAAEFIAKIFIDNERDDSSDEEDVPRVTRNGANARSTGDKAATREQKRIKLLADIEKAAGSPLAGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APK2</accession>
    <name>A0A1Y2APK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_320871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APK2"/>
    <dbReference type="STRING" id="71784.A0A1Y2APK2"/>
    <dbReference type="InParanoid" id="A0A1Y2APK2"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013299493" description="alpha-L-fucosidase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="8">
        <location>
            <begin position="364"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="845" mass="93889" checksum="625BFE94B790C52A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APT9</accession>
    <name>A0A1Y2APT9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_546584</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APT9"/>
    <dbReference type="STRING" id="71784.A0A1Y2APT9"/>
    <dbReference type="InParanoid" id="A0A1Y2APT9"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012756500" evidence="13">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="14">
        <location>
            <begin position="37"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY24583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="249" mass="27804" checksum="ADA38CED66FA8B41" modified="2017-08-30" version="1">MLTKILALAVLLAHITASPVEKRQDGVQVINNCEVSGQLALTYDDGPWNYEEDISNQFTAAGAKTTFFLNGNNYVCIYDRVDQIRALHAAEHTLGSHTWSHADLTTLSYDEIVSELEQVEDAFVKILGVKPLYFRPPYGSYNDQVLQILADRGYKKVILWTEDTGDANGESVQFSENVIDGINDFPNPHLVLEHSPIDTTHSQVVPYAISTLQERGWQLVAIDTCLGSNGEWPYEYVGEPGTPDDTWHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APU8</accession>
    <name>A0A1Y2APU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_590556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APU8"/>
    <dbReference type="InParanoid" id="A0A1Y2APU8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="337" mass="37415" checksum="7AEB452FA0E5C1FF" modified="2017-08-30" version="1">MSAFSSDTTTVTPTFEQIAQGTLLLLTSQRNLLPDYTIPHDKLLRSANRNSLRQLAKSHVPSYSEYHSMKSERGLPITRESDYGKDEIPGMADSLAETMLDAIEISSRLAAFPGSLTEKVNKYIASDVQFESGHKSEENRQDGISTVTKSELDDDRSQMAGSLRDAIEIFTMVGSLDDGHGRTPWHRVHRLIARAVPTYNSYIEEGHESSAADALTEGHESSAAGALTESEYHDRRERKIGVIEAAFWSVVGITDDERWQESVTNAKERVNRTNRSSTLPGRSKKTTNWMASVSASTKSQCQPHGDATEFTMPGAWMPEWSSCFHNQTEAVLKSIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQG7</accession>
    <name>A0A1Y2AQG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_546722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQG7"/>
    <dbReference type="FunCoup" id="A0A1Y2AQG7">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQG7"/>
    <dbReference type="InParanoid" id="A0A1Y2AQG7"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="219" mass="24228" checksum="8442ECE3C1BA6169" modified="2017-08-30" version="1">MSESRPINPEVINRPLVLCGPSGTGKSTLLNALFAAHPGQFGFSVSHTTRTPRPGEENGVAYHFVSKDEFMQRVERGEFLEWAQFGGNCYGTTFAALTALAPKRCILDIELQGVLQLRDKAPLQNPPLSPVFLFLAPPSLPTLKQRLRGRGTETEDSMRKRLDAAKAEIQYAQEGKHDVYIVNDDLKAAGDKLELVAMGWKGWESCGDKLPEMDIKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQJ6</accession>
    <name>A0A1Y2AQJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_590691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQJ6"/>
    <dbReference type="FunCoup" id="A0A1Y2AQJ6">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQJ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AQJ6"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="88"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="552" mass="60658" checksum="21CEEC1CEDA158CE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQZ7</accession>
    <name>A0A1Y2AQZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_499752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQZ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQZ7"/>
    <dbReference type="InParanoid" id="A0A1Y2AQZ7"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="507" mass="55675" checksum="8CA8F4B4B0C246BA" modified="2017-08-30" version="1">MTMDSSLLLPVPNRLEPFWLQERDVQLKSARTTVDIPSTCDVVIIGSGLTGAMAAWNVYQELEDCQKRANVVMLEADEVCGSATARNGGHCKPLTFIGYRAEASKHGAEIANQLLRFEAGALEMYAKLVEEEDIDCDMHVTRAFDICFTAEGSDSAKKDWDARMAAYPDCMRDSDVRRVDDKQTLESLTGVQGGLWGASYPAGHLWPYKLAASLIRKCIAKGMNLQTYTPATHLFASPAGWTIETPRGNINTKSVVIATNAYTSSILPEFKTKILPVRGSACSITPAPSHSAGAVPGPLRYTYGLRFGTGEVDYMIPRQGRGRIPGRGDQSYILGGAKGCFLSNLDEWYNNKRDNEEMPGVREYFEGYMAKYFAKWDGNENGNVDRVWSGVLGYSADLLPYVGEVPDRPGVFICAGFTGHGMPRIPGCTAAVSKLVSAFVIDSAITPSVQSQFEASLPKPYWMTKDRLVSKQNLIKSAMGQLVDEEVINARGKEEHLNTVCKDLRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR44</accession>
    <name>A0A1Y2AR44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_545139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR44"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR44"/>
    <dbReference type="InParanoid" id="A0A1Y2AR44"/>
    <dbReference type="OrthoDB" id="2563380at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="714" mass="80363" checksum="93F67EBDB2A8804B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS01</accession>
    <name>A0A1Y2AS01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_544468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS01"/>
    <dbReference type="FunCoup" id="A0A1Y2AS01">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS01"/>
    <dbReference type="InParanoid" id="A0A1Y2AS01"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="158"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="253" mass="27211" checksum="B08C682AECB9F6D6" modified="2017-08-30" version="1">MSTSRLEILNDGGLRHDARRPYELRSLSLSLSPHPTADGSATVTSGLTSVTASVFGPREPRSRAGTSHDRGIVSVEVGVAPWSGTREVRRSRGDKRLTEIAASIRQTFEPVILLHLYPRSEITINIQVISADGGILPTAINATTLALLDAGIALLDYTTSLSVGLHLTQPLLDLSAPEEADLPHLVVASCPASGKVTLAAMETRLHVDRFEEMLRLGVDACRVIRDEMESVVKKKAAEVVRRSQAVIGVPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS88</accession>
    <name>A0A1Y2AS88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_590190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS88"/>
    <dbReference type="FunCoup" id="A0A1Y2AS88">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS88"/>
    <dbReference type="InParanoid" id="A0A1Y2AS88"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="113"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="313" mass="35600" checksum="2FFEFAD029E32CAA" modified="2017-08-30" version="1">MTVPVSSDPDNWIEHIRQCKHLPERQMKLLCGRVRDLLLEESNVHLVQSPVTVCGDIHGQFWDVLEIFRQGGEVPQTSYIFMGDFVDRGYYSLETLTLLMAYKARYPDKITLLRGNHESRQITQVYGFYDECMLKYGNSSVWKACCTVFDHLNLAAIIDSSILCVHGGLSPDIRTLDQVRILPRAQEVPHEGPFCDLMWSDPDEVEAWAVSPRGAGWLFGRKVTAEFNYVNSLTLIARAHQLVQEGFKHMFDDALVTVWSAPNYCYRCGNLASIMQVDSEGKTGFKTYEAAVENNTDTKNTALRRLQAPSYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASN2</accession>
    <name>A0A1Y2ASN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_590172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASN2"/>
    <dbReference type="InParanoid" id="A0A1Y2ASN2"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="532" mass="59366" checksum="2C2539F2228A6103" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT98</accession>
    <name>A0A1Y2AT98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_285437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT98"/>
    <dbReference type="FunCoup" id="A0A1Y2AT98">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AT98"/>
    <dbReference type="InParanoid" id="A0A1Y2AT98"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="389" mass="41365" checksum="D97F89AFBA0917B2" modified="2017-08-30" version="1">MGQPHHIVIIGAGIVGCSTAYFLVQNELLQEETTVTLVEGTEVAAGASGYAGGFLAKGAEWHRPETVDLSQVSFDLHRELAERYAGETKWGYRAIETYVSVHSSPAHLQNIDINLSLPKVQSPTHWLPHTSRVVPKGDMSSTAQCMPMFLTKHLCAETLRHPNAALVIGRAMAVTEKNGAITGVVVRREANGVTEAVTLPCDCLVLAAGPWLGKLATQLLGPEVGRSLDVSGSQAHSIVIKPKEDLTAHAVFAKIEMGGLPDENEPEVYCRPDGTIYMCGTAGPDPLPATADKIPVSHEALKKLHSEARALTPILWSENGAQVVMEQACYLPRPARGRPLVGKVKGIQGVWVGGGHDVWGIVQGPGTGKVISEMILGLETSADVTGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATE9</accession>
    <name>A0A1Y2ATE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_590175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATE9"/>
    <dbReference type="InParanoid" id="A0A1Y2ATE9"/>
    <dbReference type="OrthoDB" id="549336at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="464" mass="51736" checksum="2420BC167753210F" modified="2017-08-30" version="1">MAVLVLATQTILSGTPDRLTHLNCSSSSPGTQLTVDLRHHDSLPRSFKSFPGIKLAVIEQTRYHEEVIGGVLSILHDMELDYDFYREHESNTRRGPQLTQGDAKFWKGWQEVLDPLQQSEGPHVVCLYHEIEGFGRSEDVDMLAPIALHGRLSLLSLGQHSATHLHKKVLKLAAETRDRRWETVSVSHFAPVFRIPDTARPETPVVLPSPAGSILSKAAILGRVQQESLDYSGIFAELLSNIQNNPNLWGYRSITVPSTLSSPDVDDDQSVNIVPQASRQRFVPLDGRLDSRFTLHLVGKDDRKVRIPEELADDEFPIVVRHPELQYDQFYDLIGAMDIVLPAFSTYHYLDSRSSAAIPAAIMAQTRILASPLLLESYTYVGGPAMCLVPTSLSPIAAIALLRASKDPWEELSLDRNNAISASSSMLRLQSPLLPDYDWEGYQTEVALMNIESWATLLSRVVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU35</accession>
    <name>A0A1Y2AU35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_542447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU35"/>
    <dbReference type="InParanoid" id="A0A1Y2AU35"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="249" mass="26210" checksum="4803F5A2E3418D8C" modified="2017-08-30" version="1">MSISTTPMPHNLTLTRDSQGNRVVSHRAGASTSHVAKGTDDTATTAAIVFTNASSVNGMNISSGDGRPQSPRSLQLSNLGHSTPSPSRPSSIDSSVLSTAKSSTAHSQSTSTLFPHSSIPFPSISPPISTELAGSSAGSYYLPQVTPGRDSRTSIMPGSTHHSSMVTHPPPSHGRPLKDYVSLDKEAKRVRGLYGPTDVTPLNPTNRSYISRPQPLAPLGARPVHAPSAPSRSSSNPRRRLFSFDRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU65</accession>
    <name>A0A1Y2AU65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_470966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU65"/>
    <dbReference type="STRING" id="71784.A0A1Y2AU65"/>
    <dbReference type="InParanoid" id="A0A1Y2AU65"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="305" mass="33854" checksum="9BF456316EB502ED" modified="2017-08-30" version="1">MTLSFTSFANVAVAGATGRLGPAIVDALVEAGFNVKALTRTPGAKYRPEVEVVVVDYLSPRELVEALQGQNVVIVFGAWRHPGQLNLVDAAIEAGVYRFIPAMFSNDLTNPLVRQLPVHGTKLKTEAYIKAQAALGAITYNLIATGPFADMFLPKNTWINKSDHTVAFFDGNPDSPFTGTTRYTLGEAIISILRTGPTSDNRTYKIQRFRSSPKRMLELVKDSTPGYEWKFKEFDTLEMARLCIDKPPETDPDCKNAYLSRGVHHEGYGGDFPSEDSLELGLEIWSEEEYKERLIDYINGKPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU93</accession>
    <name>A0A1Y2AU93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_269445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU93"/>
    <dbReference type="InParanoid" id="A0A1Y2AU93"/>
    <dbReference type="OrthoDB" id="2564483at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="214" mass="23652" checksum="39B297CE908A97F7" modified="2017-08-30" version="1">MVKSHRSPSTFFHQWPTTPSHHDHSQKQKPLHNIAGTPGSPFSLDPFGSQVTLPEPIRSSRPNSITSATQLVHGSSTTPKIVLASPSTSTIHYLFPSSETRSNLSTSTTERPKSVRAKSRPPITARRSFEQVEKEKTAQRKILEGSFPLPPSRREPEAKASERYREPLGSAKRVPSGTLSNMPTLKRQPSMADLGKAKGMKVDIERVRLTIVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUK6</accession>
    <name>A0A1Y2AUK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_541816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUK6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUK6"/>
    <dbReference type="InParanoid" id="A0A1Y2AUK6"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000145">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000162">
        <property type="entry name" value="HAD-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="333" mass="35593" checksum="F74C90A9649431F1" modified="2017-08-30" version="1">MTVTVTATVSKPASYTNKATFVADGVLFDMDGTLTDSIAAVEAAWTAKADELGLEPEVVIAATHGRRASDNLMELVPGLRKEHVEREVEKFEKTILDFADTPPQSRKGSFSSSRKSSFAAGTRALSGSTLGSLSPMTPIGGTPDQRSSGAYRPDIALAFTSFKLGNSEVDVVTADDTPFEDEDEEEEKLLDMSVRILPGVRELIDSLPEGKYAVATSGAKTYCHGCLTRTGITIPKVCVTADDKRLLRGKPHPDPFLLAAKDLGIDPTRAVIFEDSPSGIKAAVAAGSTVIAVCTSHKREQIDKLGAHYVVDTMDQVKVEHLPSGELAFTVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUW0</accession>
    <name>A0A1Y2AUW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_560657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUW0"/>
    <dbReference type="FunCoup" id="A0A1Y2AUW0">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUW0"/>
    <dbReference type="InParanoid" id="A0A1Y2AUW0"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17231">
        <property type="entry name" value="TGS_DRG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="71"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="298"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="376" mass="41605" checksum="9D44E0D8C1BAFCEF" modified="2017-08-30" version="1">MGVLEKIEEIEKEMSRTQKKLCDPQQSNGVSPRPAQGRTVEQFAKYRAQLLEPPAKSAKGEGFDVLKSGDARVCLIGFPSVGKSTLLSKTTKTESSVGAYEFTTLTAIPGVLEYEGARIQLLDLPGIVQDAAKGRGRGRQVVSVAKTADLIILMIDATKSAEQKHLLEVELEAVGIRLNARKPDVVFKQKAAGGITINCTVKLTKTDERIVRSILQTYRIHNCDVMIREDITTDEFIDVILGTRKYIPALVAINKIDSVSMETLDKMAREGDGRTVMISCELDLGIDWLLESIWRELGLVKVYTKRRGEQPDLSDPICLRQGATIETVCHGIHRSLASHFKYALVWGKSSKFNPQPQKVGLSHLVQDEDVVSIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVD5</accession>
    <name>A0A1Y2AVD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavin reductase like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_261559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVD5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVD5"/>
    <dbReference type="InParanoid" id="A0A1Y2AVD5"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="59"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="305" mass="32862" checksum="3B3C326721E61774" modified="2017-08-30" version="1">MSMRRSSRAWYAMRGRRCLSSYHDVSEQLRDVMRDVPQHVAIAVTSVPHESSSPSSSSSSSTKSKYHGTTLSSFTSLTLHPYPLVAFSIRLPSRMADYLRSSPSPSSLLPSSNSTQTQSSSSATNSTSDSSSSPSNSSTSTSNGIQEPSSNRRSLTISLLSQPSQSLAHALSKPMSDQSSTFSSDSLWTDTDPPSAASCVGSLRCEVLSSTLLRDVCYAHDDVEVRVGEGDGEQGPSLQERSGLEENADRGRIPGEGDGASTTVHGSELFICKVLQVTRGSISDRDQPLLYWRQRYTSVNSTQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVL3</accession>
    <name>A0A1Y2AVL3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_541378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVL3"/>
    <dbReference type="InParanoid" id="A0A1Y2AVL3"/>
    <dbReference type="OrthoDB" id="2564873at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="290" mass="31501" checksum="EE9D5B0A2114E0D4" modified="2017-08-30" version="1">MGRSFGSTLGCDRGRWVMTAQPRHLPFEAGVEHSKSNSSLKMEGNSTSMAEVELDDSIKMDRQTSEFSVSAYMDFTEEDEAIFDMSKPLVRSASKTASTPFNTPCIHRETIHRSGRVSRRKATIALTDSSTGSSSSSSSSTGSMPSLMCRLDSQVVAALVALESTLFTPELDYALGLGENLDFELTPIPAPAQNANVAVGAYEEMTRQLDLGLGLGLDMDIQNNTIYHLPVRSRLPRLTGYVRPCSSRPDGVVRMPSLGKQVRGDSDMLRITDLDTGVSRNVHVASLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW33</accession>
    <name>A0A1Y2AW33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_470168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW33"/>
    <dbReference type="FunCoup" id="A0A1Y2AW33">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AW33"/>
    <dbReference type="InParanoid" id="A0A1Y2AW33"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="68"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY26664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="364" mass="40850" checksum="B6EDE621C8C9BD1B" modified="2017-08-30" version="1">MRRELNNGNRSGRPYQQGPSEGYRPASQGAPTISLPPPPSEPTAVHPSPPSESNDAHPAKASRGGNTYDLLTCVGEGTYGKVYKAKKNDTGLIVALKRIRMEGEKDGFPVTAMREIKLLQNLRHENVIRLHEMMVSKGSVYMVFEYMEHDLTGLLSLQGINFTPANLKSLNYQMLSGLAYLHDKSILHRDMKGSNILLNARGELKLGDFGLARVYSKFKRDDYTNRVITLWYRSPELLLGETVYGPTVDTFSAGCIMLELFTTKPVFQGNDEIHQLEVIYSILGTPSEEDWPDVKDLPWYELVKPKESLPSKFREIFSKWLSPAGLDLAQGLLAFDPARRLLADQAMQTPYFTSEAPPMEKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW92</accession>
    <name>A0A1Y2AW92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_539834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW92"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW92"/>
    <dbReference type="InParanoid" id="A0A1Y2AW92"/>
    <dbReference type="OrthoDB" id="2596903at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="694" mass="74072" checksum="F23672F76E616050" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWY2</accession>
    <name>A0A1Y2AWY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_578143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWY2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWY2"/>
    <dbReference type="InParanoid" id="A0A1Y2AWY2"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="3">
        <location>
            <begin position="793"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112946" checksum="70C352ED40E05DE4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXA5</accession>
    <name>A0A1Y2AXA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1275 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_539143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXA5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXA5"/>
    <dbReference type="InParanoid" id="A0A1Y2AXA5"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="271" mass="29814" checksum="D12271ECC324E888" modified="2017-08-30" version="1">MPQSLVGHPSSPFDEEPQRNNFKRKSWRAYLAQEIDPQWTDLVLLAGCFITGLLDSAVFNVWRCFVSMQTGNSVYVGLGLSSQPATEPYRYMKSGTSILAFIVGSYVFSRLMRFFDPLRRSTLFLASLVQNVFCLVPALLVVFSAVPPDAGDRLPNDFTVLLPLALLSFQAGGQCVLSRVLGYGELPTVVLTSAYCDLAMDEKVFHGFQGNSKRNRRMGSIALLILGAGLGGFMTKERGLGLALWTVTGLKAIITVVWLVWPAEGGHLRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXS0</accession>
    <name>A0A1Y2AXS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_540467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXS0"/>
    <dbReference type="FunCoup" id="A0A1Y2AXS0">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXS0"/>
    <dbReference type="InParanoid" id="A0A1Y2AXS0"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="5">
        <location>
            <begin position="163"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="612" mass="66425" checksum="D366F21CAAEC83CB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY20</accession>
    <name>A0A1Y2AY20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_226822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY20"/>
    <dbReference type="FunCoup" id="A0A1Y2AY20">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AY20"/>
    <dbReference type="InParanoid" id="A0A1Y2AY20"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="278" mass="30871" checksum="05497950A1A8621D" modified="2017-08-30" version="1">MSFTKTTISSPQPAARTTLKAQQATSALLPHAPQYTIRGSIPNTPLVASLISAGLGGVATASLAYGLLPLFQSLDSTSWTWARWQLGVYGFAWGLFHLAEFWTTAGWNTQKLSVDAFLLNNTSQYHFAHLVGLSEYFISSYFFPRKFDSFITSLPFSSIVMILLIGGQAFRSLAMIHAAQSFSHIVKAVKLEDHELVTHGVYAWSRHPSYAGFFYWAIATQLLLGNIVSTLGFAIVLGRFFSARIKDEERHLVRFFGDDYIQYRKRVGTGLPLILSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYG1</accession>
    <name>A0A1Y2AYG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_228425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYG1"/>
    <dbReference type="InParanoid" id="A0A1Y2AYG1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="255" mass="28876" checksum="B3555228AABF76F2" modified="2017-08-30" version="1">MPIIYSEQSQRQHQSHSSNTLTRRHRSSPSMDFSHPPPLYTSSSAPVYDYPPPIISPPRFPSYTASIHHTPSTSSLPDHANQNPSYSDISLSTPVNSTARNYSQRHSSSSSSSSTPIHPHRYSSSSSSPSTPFNSGYNDEFNPNRSSGPTTTTTRSSRTSSTSSTYSTSSIEEEQVAYNLCQMSLALSQQRKDERAGKRTRHIDPVVLVDGQERIRRERDALEKMSQLHLERQRSIAFREWERKCRSERVRRSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYL2</accession>
    <name>A0A1Y2AYL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_230663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYL2"/>
    <dbReference type="InParanoid" id="A0A1Y2AYL2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="279" mass="30919" checksum="62F5570D7112CC7C" modified="2017-08-30" version="1">MASKRAASDLDESPSTHIVKRARKPLSPGNPPATVFSQLVHGLWGYTFGLLGEPTQTLSNGSASSSRRTLKSHPSSSAVSLANTATSSLHTPPSPSDAAEGSRALIRTYEQPDQGNSRSPIDLTYDSDEDGPSRISSPPNLPREPLAESSRYTKPRSRARIPTRPDVSIDREVRDYPWLSARASPTPSNSSSTSPARRKRSSSFRPGKQKQESLSQSHFGLDRRRLKRIERAMQEGDPKGHKAWERVWSFWSRESKKKKDRELSSKRISTSVPVEKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ81</accession>
    <name>A0A1Y2AZ81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactinol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_589059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ81"/>
    <dbReference type="FunCoup" id="A0A1Y2AZ81">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ81"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ81"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="349" mass="39401" checksum="E11EF33ED5E41CDA" modified="2017-08-30" version="1">MTADPPRRQAWVTLITNPGYVAGLLTVYRTLISVSRYPLIVMATDSLPQASRDLIQRSGISIVDVAHLLPAPGQHSGFDPAFVRLNDAWTKLRVFGLTEYDRLILIDSDMLFLRSLDDLFELELPSPEWIGAAPACVCNPLGFAHYPRDWTPANCLLLKQDRFATIDSITIPKPDAPRTSHLLNSGLVVLQPSKSLMDHLITFLNTSPTVAASQFADQDIIAEAFHGRWRPLPWWCNALKPGRWVHPNVWDDGEVRLIHYILDKPWTRRPGICKPAQNEPIKTDQYFTPGRPLPEKLTELVHNTPPQLSATDYDGVHAWWWAVYEDLLAEMKSSGPSSGWEEMDAVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ89</accession>
    <name>A0A1Y2AZ89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_536645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ89"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ89"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="180" mass="19987" checksum="AB968DB0EBDB17EE" modified="2017-08-30" version="1">MGLCCVSSKQFDDDNEETQSLMGNMGPAYDPYLEEKTEKASITSQFTTGRPESSFYSRKGTTGRPKSSLVSKVENFLRPISAACTSVDNHATRTETSLLDPYKVPIRINIQVAKITRTDGAQSTKVNTDDDQRTVGSYDDQSTQAKSTFEARSTFNAKSTFNARSSSKTSTVERRNSYNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZB8</accession>
    <name>A0A1Y2AZB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_217143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZB8"/>
    <dbReference type="FunCoup" id="A0A1Y2AZB8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZB8"/>
    <dbReference type="InParanoid" id="A0A1Y2AZB8"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="158"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="369" mass="41341" checksum="940D129A6DF9136B" modified="2017-08-30" version="1">MVTSRRLRWGIIATGNISVKFAKDLLVDPSTRGAFDVAHRVAAVGSRSVRSAQRFIDRLKTERQTSGVLESEIEQCKAYGSYDEVYDDPEVDVIYIGTPHPLHHSNAKRALEAGKAVLCEKPFTMSVGELDELIRIAKEKKVFLMEAVWTRFLPIMFRVQEVIHSGKLGKVKRLFADFSIDFNPDDWPYSWRMIDPALGGGSLLDMGPYPAVWAMMLLHRHPFNTNGKPPSLVFSHQTIYKRSGVDANSRWLLNWDGVGQAMCVTDMTAHGTHYGCVIVTCEKGDLILDGSIARPSTFHIITRGKDGPTADDEKETFNVPVPAGVGMCYEADEVYRCIRDGKIESERMPWEESRIVQGWFDEIRAAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZM5</accession>
    <name>A0A1Y2AZM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_536228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZM5"/>
    <dbReference type="InParanoid" id="A0A1Y2AZM5"/>
    <dbReference type="OrthoDB" id="2429551at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="180" mass="20028" checksum="858A00D0AEF9F212" modified="2017-08-30" version="1">MQSIIDTASNLTTSAAQTLGLQSSNTTTTTAGHQDNQGYQHSTPLPPDSTAYPIRSMDTEGLAVFEDERVRHEVLVKINQLAIEDIRHGLKQLETLDLVVQGAEKKGIDYYHPKRYFTVDRPMGVDYIGEIEIEQDKSIHVRCHKPSVDGKPTFHSLDTRPTVESGAVFKTGGPLGWFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B058</accession>
    <name>A0A1Y2B058_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_505998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B058"/>
    <dbReference type="InParanoid" id="A0A1Y2B058"/>
    <dbReference type="OrthoDB" id="2558924at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="200" mass="22416" checksum="72BDCFCF3CB7444E" modified="2017-08-30" version="1">MSGPPKYQPVPTGDGITEDDERYPETAPSYPPTSRHIFTMGDGGPSNVIYTFVPRYPLKGEPQDALGVLGRDKHNTVLIVQRGFPTLAEYPPERIEFLAPVEVDSNGRVVDDRWGTVMEEAWSRFDRDPPSRLRVQVVDLPGDAEDREVFLRTEQEARDWKEAQAFLTFVAFAITLVAVVTLIIWYNGGFETSGKSQPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0D4</accession>
    <name>A0A1Y2B0D4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_535278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2B0D4">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0D4"/>
    <dbReference type="InParanoid" id="A0A1Y2B0D4"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="762"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1152"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1486"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1502"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1513"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1536"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1587"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1662"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1703"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1744"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1921"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1933"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2018"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2035"/>
            <end position="2045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2052"/>
            <end position="2064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2073" mass="228429" checksum="C77D008EDF034447" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0D6</accession>
    <name>A0A1Y2B0D6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_536309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0D6"/>
    <dbReference type="FunCoup" id="A0A1Y2B0D6">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0D6"/>
    <dbReference type="InParanoid" id="A0A1Y2B0D6"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000077">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="513"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="876" mass="98432" checksum="24FD07AFFB4A950E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1M0</accession>
    <name>A0A1Y2B1M0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoribosyl-ATP diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_534579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1M0"/>
    <dbReference type="FunCoup" id="A0A1Y2B1M0">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1M0"/>
    <dbReference type="InParanoid" id="A0A1Y2B1M0"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="81"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="241" mass="26856" checksum="9AF4FB8BCC6270E0" modified="2017-08-30" version="1">MIRTVSRNRFKQLYVFSTTTPIKRRKTGIQIKKMSGQPEILDVQELKTEAKWLKLEKIHWKDQDGKERDWECANRTTKQPGGVDSVHILAILHHPSDPISTILIEQYRPPVGKTVVEFPAGLVDEGEDAETTALRELHEETGYGSGKADDGGNAKITQVSSVLVKDPGMTGANFQLVTVDIHLNESDPEPQQHLEEGEHIIKRVVPLKDLNATLQDYSKRGFAIDALVASVALGYQLRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1Q6</accession>
    <name>A0A1Y2B1Q6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_536255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1Q6"/>
    <dbReference type="FunCoup" id="A0A1Y2B1Q6">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1Q6"/>
    <dbReference type="InParanoid" id="A0A1Y2B1Q6"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="208" mass="23170" checksum="7910A22DC1288188" modified="2017-08-30" version="1">MGLLTIIRKNKAKSKEMRILFLGLDNAGKTTILKTLSGQSIQGVSPTLGFEIKTLIRDGYTLNIWDVGGQKTLRPYWRNYFESTDAVVWVVDSSDHLRLRDCGAELRGLLNEDRLAGATLLVFANKQDLSGSLSLEQIRDALELNRIQSHKWNIQSCSAVTSEGLEQGMKWVVNEVAGRLYWSGLKSDSSTSNQQNQHDIQNGVTVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2D7</accession>
    <name>A0A1Y2B2D7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_533383</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2D7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2D7"/>
    <dbReference type="InParanoid" id="A0A1Y2B2D7"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="108"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="207"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY28973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="307" mass="32719" checksum="BED367DF1CACE556" modified="2017-08-30" version="1">MAAVPAKKSASSEGWFTNFMMGGVAASISKTVAAPIERVKLLVQIRPLEYRGIGSTFVKVYRDEGLASFWRGNGTNVIRYFPTQALNFAFKDYFKTIFGTKRSDGYFRFLVGNVASGAAAGATGSLFVYSMDYARTRLSVDSKNAAKGGQRQFTGMIDVYKKTLASDGVLGLYRGFAPSVVGIIVYRGAYFGLYDSLKPLLPENLRGNPVANFAVGYGATTLAGLAAYPLDTIRRRMMMTVGGGTEGVRYTGTIDAFRKVVAAEGAATLMRGAGANILRGIAGAGALTLYDVFQEAVFGKKFAAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2Q1</accession>
    <name>A0A1Y2B2Q1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_533606</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2Q1"/>
    <dbReference type="FunCoup" id="A0A1Y2B2Q1">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2Q1"/>
    <dbReference type="InParanoid" id="A0A1Y2B2Q1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="450"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="658"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="222"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="961"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1011"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="964"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1024"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY29016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1221" mass="133643" checksum="4DF2F010D3380525" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2V9</accession>
    <name>A0A1Y2B2V9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_588449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2V9"/>
    <dbReference type="InParanoid" id="A0A1Y2B2V9"/>
    <dbReference type="OrthoDB" id="2589888at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1496"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
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        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
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        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="718"/>
        </location>
    </feature>
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        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
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        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
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        <location>
            <begin position="897"/>
            <end position="934"/>
        </location>
    </feature>
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        <location>
            <begin position="1060"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1570" mass="164309" checksum="D482131786EA1BF0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3F1</accession>
    <name>A0A1Y2B3F1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_533540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3F1"/>
    <dbReference type="FunCoup" id="A0A1Y2B3F1">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3F1"/>
    <dbReference type="InParanoid" id="A0A1Y2B3F1"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="372"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="467" mass="52181" checksum="3189D8441DFA04E1" modified="2017-08-30" version="1">MAEGDFTKRKLWGGRFTGSTDPLMHAFNQSLSYDKRMYAADVKGSIAFSKALLKAQIVDEREQAEIERGLKVVETEWRDGKFIIQADDEDIHTANERRLSEIIGKDIGGKLHTGRSRNDQVATDMRIWLMDETDKVEGYLKNLLQVMVSRAEKEVDAILPGYTHLQRAQPVRWSHLVLSHAQAFLTDLSRLRELRPRISVLPLGSAALAGNPYSLDRELLRAELGFASIGENSMHAVADRDFVVEWLQWASLCMIHMSRMAEDLIIYSSGEFGFVTLSDAYSTGSSIMPQKKNPDSLELLRGKSGRVFGQMAGFMMSLKGVPSTYNKDLQEDKEPLFDCVDSISAALQIAEGVIATLTIHPDKMLKACTMDMLATDIADYLVRKGVPFRETHHISGRAVALAEQKQCQISDLSMDQWTSLSPKFTQDVMDVFNFEASVEKRNAIGGPARAMIARQVQVARKRITGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5J3</accession>
    <name>A0A1Y2B5J3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_558827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5J3"/>
    <dbReference type="FunCoup" id="A0A1Y2B5J3">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5J3"/>
    <dbReference type="InParanoid" id="A0A1Y2B5J3"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="228"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY30004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="328" mass="35897" checksum="93C0150DA3409F79" modified="2017-08-30" version="1">MSAESANVNGTAPAAETEAAAPQEEGFRVYIGNLAYTSTEEDIRSFVTKAGDYEILSVVMPKKFGKRPAGFAFVLYKNEEDAKAVVEKLNGEELGDRKLSLEVARSKEEQAARREAIIEKRNAAKAEKAEQKAAASGAEQKAEGDEKTAEGEAKPKKKKARKPRRRVPEEGEDSSTAVEGGSSEVKSSKSSRSRVPREARIDEDSEPKERKPRERKPKLQLTNEQSESTVFVANLPFDVDDDALAAIFTNLSIRVKSAKVIRGLRSGRGGRRFYASRGFGFVEIEDAAQQKEAVEKVEGSLIGDRTISAKIAQEMKPIEVENATEGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5M7</accession>
    <name>A0A1Y2B5M7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5M7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5M7"/>
    <dbReference type="InParanoid" id="A0A1Y2B5M7"/>
    <dbReference type="OrthoDB" id="2575262at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="500" mass="52922" checksum="E98F98F66C631ACE" modified="2017-08-30" version="1">MPAPSSARHSTPPQTPPREQLSPSTQALISLSQDITALISLSVEAGASLVNDWFRSTLGLIGLGEVVQYSPGTNDSTKPKGRGESVRGLAIVVVGASEATGQSLTLHLAKCGYIVFPLLPLPSPDSPPTSAAFSHLLLTWSGIQKRLRIRNPRHPGAVVPIITDPESSGFITPSKAKGRFQHAGETVRIYCRDNGLELVAVVCASQGPRKSEDGGDEEIEPPSTPPTQLPISPSPSPTSRGLVPLPAPRHVSLGGIAKADETTLLNLYRTNILDPLSITHELSDLLAATSTTGRGSGRVVLVNGGSNTVLSTVTDDDESGVMQIVGAARGEMTKLLRKELARAGIDVCEVVVGMSKAHISHTRKFLTGPGPMTPRIAGPGYHLRSGSDESNDSNHSQTTAVKAVLLRASEGEGFSDSTESEKSRQAILASRLHLLSRLWAVDDALLFSSVRRAIEDRYPRAKHHAGISPLIESLVGVVPGSGLIKVVGRWVVGRLLMPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5S1</accession>
    <name>A0A1Y2B5S1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_529889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5S1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5S1"/>
    <dbReference type="InParanoid" id="A0A1Y2B5S1"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF247">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="362"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="516" mass="56476" checksum="A4613C394CCE98F2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5U3</accession>
    <name>A0A1Y2B5U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_529982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5U3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5U3"/>
    <dbReference type="InParanoid" id="A0A1Y2B5U3"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="137"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY30211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="377" mass="40976" checksum="AF601EC1BAC06E63" modified="2017-08-30" version="1">MTKRVMSTLKIALLHQAAPQPAIGGVRKPMKPGGYADGCADIAHALQSIGETVITPHPNSSPSPIVDLDWSFPDTQSGILQALSLGTNLIWPNTSMHTRHPLVDLLPELEAKGVQIVGQNVGVVEEWDDKAWLNAWLSSQKGLEGWFPKAKLIKKGDATNWGGWGWPAIAKPVRGRGSHGVKRVSSEVEMEEAIEVLLKESDEVLVEEYLAGEEITVTVMPPGKYSVVGDKAKHWALPVVTRFDQINGVAPWNGTVPVSANSRVVTQTEHDTDPAYRTIQEKCELVASIGEATAPIRIDCRRLNESGGDFVLFDVNVKPNAGGPGRPGRDSQAALTTMAAEAIGWSWPEFAREIVRGARPPREILVPRVIRKLSQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6C5</accession>
    <name>A0A1Y2B6C5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-keto sterol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_531477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6C5"/>
    <dbReference type="FunCoup" id="A0A1Y2B6C5">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6C5"/>
    <dbReference type="InParanoid" id="A0A1Y2B6C5"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49084" checksum="583AEC5FF7D87B0B" modified="2017-08-30" version="1">MVTTRSSRSHPSPDENRMIAVVTGANAGFGFGICVQLLRNLSLPSGTPLPLTAQVSKIPDSPASLKDNCSSSSSSSELLARPPPTFTLILACRSQARAEKARTLLLARHDKELARRKKRGLPIREGWREGLRVEWEAVDLDAMGGKNEYWQKYPHITSLYLNAGITNTPGLNWLAFVKQIFVDGLSYAVSHPTFVLERAGVMSADGERGMPWGINVFAPYILARELEPMLRRSPASLPHSPRIVYTSSVTSTPDALKPDTMSDYQLLTYNDGVRYSHYKASKYMAEIIMVQLDQEFATRPETKGEHQVRCLTADPGCVPTDIFREAWGGEHWIAEFLFIGYWITFYLARLFGSPWHPVYTSEGASSMVYAGLVEDKYLSTPDKVPAEKLITVSSRWGKTTVRHGEVDRWEETQDLGRDLVQACETLRLQWRRREGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6W6</accession>
    <name>A0A1Y2B6W6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_505099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6W6"/>
    <dbReference type="InParanoid" id="A0A1Y2B6W6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="189" mass="21302" checksum="4ED0D744B3F21EEE" modified="2017-08-30" version="1">MNTSACDCQDSLNSILKIPAFIFIALLLYPRWIQGFQDDVLQLFPDLRWTLSDYAIDVIWGVAGAIFALVGGITAAAPSMKHQAVAASEMRCLVIIGNIMLAEGIILSAFAPIQAIRDFIRDLDPSNFVWIPRRESAWNHASVWVQTFKFVLLLMLAIFWFAAWTIRGVWNVIMGLSNWVCRPMRRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B888</accession>
    <name>A0A1Y2B888_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_455471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B888"/>
    <dbReference type="InParanoid" id="A0A1Y2B888"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="128" mass="13860" checksum="0057C4E722C0F143" modified="2017-08-30" version="1" fragment="single">GGTEHERRAGSYKVGTDKAYHDLSLANELYRRALYFRPSSITSMQCRAKVLIQLATTYQPLPTAMLSLQEAVALGRHLADLAPTSVSARETLAQAASLLSSILLETGNKVSSRDEDAGDLAREALQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8F2</accession>
    <name>A0A1Y2B8F2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_529569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8F2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8F2"/>
    <dbReference type="InParanoid" id="A0A1Y2B8F2"/>
    <dbReference type="OrthoDB" id="2575974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012124090" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="56467" checksum="08E4D9E52020A292" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8F6</accession>
    <name>A0A1Y2B8F6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8F6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8F6"/>
    <dbReference type="InParanoid" id="A0A1Y2B8F6"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000193">
        <property type="entry name" value="Glycogenin glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="830" mass="90129" checksum="06F77C580C266CE5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8W1</accession>
    <name>A0A1Y2B8W1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_504874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8W1"/>
    <dbReference type="InParanoid" id="A0A1Y2B8W1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="328" mass="36620" checksum="74F25E8519F34A93" modified="2017-08-30" version="1">MDFIPRAFTAGTEDTGDPWTHDMLDISAYVDTTSTLDQVSSRTATKRSFPFAENDGICSKLPRLSPPQIVSYNTRQGVSSGGDPNRRAIGSDYPSNPNLLTKLGTTLSQTGELHFSQATLTQLDTILTSKGEDTDEIFVPEELLIGRKWKENERHRLVYTRDCGMETLSGWTIRKLEQQPCPSGHDDSDPDPELTLEKWRNDVTGDLLAVQSQGTERDKEELETYCLSAHRELQSLYEMTVPGDDDDDDDDDDDDDDDDDDDGDGGDGGDGYEDPEVDLKTVASGNRNWKDVAMGDENETDDEEEEDKTESQRGVWNGKYSHVVVFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8Z6</accession>
    <name>A0A1Y2B8Z6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_109788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8Z6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8Z6"/>
    <dbReference type="InParanoid" id="A0A1Y2B8Z6"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY30565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="204" mass="22970" checksum="1CCA0F1E16631350" modified="2017-08-30" version="1">MYSTFQRLNHLSSLATTYVMILLGLISIASFLSLPEVDAGRIDVKDIILQKGRLRRWGAREEELASLRFDIRTDLNPLLKSYNTKQLFLYMTASYPEYDPSSGSVREQHDVVLWDRIVQRADIRDIRAVGKKIPAGKGKKGRGNIRVEEGKNKYMWTNPSGTFRDVPSANLTLHYSLMPYVGVLSSGIAATAQGPITLPEVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9B4</accession>
    <name>A0A1Y2B9B4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_465676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9B4"/>
    <dbReference type="FunCoup" id="A0A1Y2B9B4">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9B4"/>
    <dbReference type="InParanoid" id="A0A1Y2B9B4"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="331"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="832"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1073" mass="121320" checksum="E0A647D65FEA85E2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9R7</accession>
    <name>A0A1Y2B9R7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ornithine decarboxylase antizyme-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_593350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9R7"/>
    <dbReference type="InParanoid" id="A0A1Y2B9R7"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="332" mass="35704" checksum="3A1D7742E7C85FAF" modified="2017-08-30" version="1">MYTKSSQRTDRYSGASGSAGDGAPPSLPLLFSQYHHHDIDNPLSPPLALARVGGEGGPVFVYSDEPLMGATQGGCTSFAGGGRQDSLTSYLFPFSQRSFPGQQHISSVNGRLNNALTPPSSFSPNMTLPLAMPCAPMSLPLTPESSSSPVHRSASMPSITETRDTPVPLISALFPYHATMAAQMSHRLEIVTPPDHVLQGFILDHPECGRAVYIHLPPPHVSASDRPEYLAPHFSAVLRPHDPKLSTSPEQASSLQALDIRESLTALLDLASDSLKATSLILVLDQDDRGQEGLGDLLHSLMYVGGQVVKPGMLEGGWEWDPRRWVLVGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAB2</accession>
    <name>A0A1Y2BAB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Six-hairpin glycosidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_525995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAB2"/>
    <dbReference type="InParanoid" id="A0A1Y2BAB2"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012960185" description="Six-hairpin glycosidase-like protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="46544" checksum="32CD1D45961E7694" modified="2017-08-30" version="1">MKALLCLIVIASLPSLVSAVHLTNSSIDHIFSVLQNISQYSWENGTKSEALLEKTYPSLSVFSPTAPLPLPADLSQDDISQILDIAHTTLSNRPATNTSVSAHGGSPLLSDGAAGDPASLGVAILLANWSTNNALWNNVGYGDAATMELNYLLYDVPRSAQGAISHRADQVQYWADFVYMVPPFLAYYGALHNNQSLLQEAYTQCSLYRGQLRQSSGLWNHIEGGTTNNGGSHDPNPCGGMLRVLATIKWSGFQSQMSSQMSDLQSWVEEILTATQQYITSDGLLRNYMTDSTSFEDASGSALMAASGIRLSTLNLTNDYINQSLTLLSAVSSKVNSSGYVTQVVNPTDFSTQGTQSPEAQSFLVMAYSAYDQWDKQGRPGFQSGEGSSSSKGSNGDPLGKSSSSGFKRFHIGTGTGTGIMASLVVGGLVLGLSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAE5</accession>
    <name>A0A1Y2BAE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative guanine aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_525537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAE5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAE5"/>
    <dbReference type="InParanoid" id="A0A1Y2BAE5"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="78"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="474" mass="52140" checksum="28A9331C2934BCBA" modified="2017-08-30" version="1">MSQLFIGTFIDTPSPSSLSSSSSPSKSQLQIRKSHLLVTSQGIITHLSPSDSPSSQSILSDPSSPAPIFVGGKYEFFLPTYTDLHLHAPQYLYAGTGLDMPLMQWLDQYAYRAEEKIDSDLLLARRVYERLCLRLKQGGTGCVSFFGSLGVDSNMILAECVQKAGLRGFIGKLSMDQSPRPTYGEPSTEVSLASVTTFLDRMDELVSSLPPHERLVEPILTPRFVPTCSDELLSGLSKISKERGVRVQSHMCESADQMAWVESTRGKRDEEVWDEAGLLGDKTLQAHVTTLPPDLISVLKSRGVTCAHCPLSNAYFSDAQFPLREALDAELKVGLGSDIAGGYSLSIETSMRQAVVTARLREGARREGGGAVKVDEKGLRVDWVESLYVATRGGKMAMGLGGCFEIGMEFDAQLIQVADEKTDEGTGKLDFFDLANEEGEDVDDARWTELVERWWCNGDDRNRKGMWIQGKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAN8</accession>
    <name>A0A1Y2BAN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_465334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAN8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAN8"/>
    <dbReference type="InParanoid" id="A0A1Y2BAN8"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="118" mass="13021" checksum="2FD892F59B86451D" modified="2017-08-30" version="1" fragment="single">MFQTETGLDGDDDDDDGQYHLQPGRRKIRIEYIADKSRRHITFSKRKAGIMKKAYELSILTGTQVLLLVVSETGLVYTFTTNKLQPLVQKAEGKNLIQACLNAPDGFGPDGQPLGGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAQ4</accession>
    <name>A0A1Y2BAQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_465115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAQ4"/>
    <dbReference type="FunCoup" id="A0A1Y2BAQ4">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAQ4"/>
    <dbReference type="InParanoid" id="A0A1Y2BAQ4"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="303" mass="32281" checksum="5D1D4781CF0DFB65" modified="2017-08-30" version="1">MSAVPKLLVVGGNGFLGSAICKAAVSRGWEVSSMSSSGKPYKTPAGHTPAWSQSVTYHAASAFDPPSFSSLVADSTAVVHTIGILLEDAKYKQNIRDGNLLGLARSLLGVDAGNPLKTAQDKLSGYEGMNRDSALNILDAMLSPTPSSSSSSSKTRPFVYISAADAFRPLIPSRYIETKRQAEQEITNRCLASPEAHIRPLFMRPGLMYHPHIRPLSTLPAFLLSLTATLAEHTSGSNPFASKSALAGAAEAMRTHPIHVDHVAEAVVRCIADENKEGVVEVNTMREWAGFNGRGGRREAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAZ2</accession>
    <name>A0A1Y2BAZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gti1/Pac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_465168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAZ2"/>
    <dbReference type="InParanoid" id="A0A1Y2BAZ2"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="235" mass="26251" checksum="C78515854BDF170F" modified="2017-08-30" version="1">MLPSGPLPSLDPPFRGYIETTFDALLVFEAARRGMIPRVTRRLIERERGMVQSGAVFVFDEHESGIKRWTDGLIWSPSRILGNFLVYRETDKKNGNPPTPISTHPSSSPSDLPMGIPHQIPQYGESSALHRPQSSGDGGSLDRQKERQLVGSLTNSYKFKDRGLVKKTMSVTVNGFAQHMISYYTVEDVLAGKLRSPSTIPELAALEISPEYLHKANFRFPPMVEIGPDGIPRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB49</accession>
    <name>A0A1Y2BB49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_524040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB49"/>
    <dbReference type="FunCoup" id="A0A1Y2BB49">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB49"/>
    <dbReference type="InParanoid" id="A0A1Y2BB49"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY32068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="140" mass="14835" checksum="1FBE9EA72197D162" modified="2017-08-30" version="1">MPPKSSVASKAPASQASKAPAASKAPAKAAKTSAAKAEGGKKRTKKRVESYASYIYKVLKQVHPDTGISNKAMAILNSFVADIFERIANEASKLAAYNHRSTISSREIQTSVRLILPGELSKHAISEGTKAVTKYSSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB60</accession>
    <name>A0A1Y2BB60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_524048</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB60"/>
    <dbReference type="FunCoup" id="A0A1Y2BB60">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB60"/>
    <dbReference type="InParanoid" id="A0A1Y2BB60"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="396"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY32072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="808" mass="91541" checksum="772CF87388086664" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBB4</accession>
    <name>A0A1Y2BBB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RIC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_524218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBB4"/>
    <dbReference type="FunCoup" id="A0A1Y2BBB4">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBB4"/>
    <dbReference type="InParanoid" id="A0A1Y2BBB4"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="780"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="947"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113173" checksum="2604DB130FF68994" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCF7</accession>
    <name>A0A1Y2BCF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_524437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCF7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCF7"/>
    <dbReference type="InParanoid" id="A0A1Y2BCF7"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="163" mass="17921" checksum="794B43A1F41495AE" modified="2017-08-30" version="1">MPAAPKRPPQAGPSQPSRQAEALTEFQSRRLLRRLDELERTNPTDIPASSFNPPPPPLPPSSHPTSTQLGFSQQQQPKKKQSANVRRILYGKKSLKDWLDELPSEPKPPYILAATSPPKAPPRQLCSSCGYFGAYKCPRCAEWSCDMACMQVHARDGGCGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCK9</accession>
    <name>A0A1Y2BCK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_523320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCK9"/>
    <dbReference type="FunCoup" id="A0A1Y2BCK9">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCK9"/>
    <dbReference type="InParanoid" id="A0A1Y2BCK9"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="260"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY32217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="405" mass="43901" checksum="037A54DF2D37708A" modified="2017-08-30" version="1">MFIAIVGTPSAGKATVLEYLERKHGFKTVGLEGTAGMLGVGESKMTSSRVDVSHMNGLSISGSSTSVTTSVESPISPSPTSPSPSPRIFSSATALLDYMTRNWLDHHVTTDLRTYDDIELFLKRPSFLLVFVDGPVRARFERERQRSLEARGKIISLDEFIDQHDLLYNGPSSSTCSSSNSSSSSSSSTTNTPSTSTSTSTSLSSTPASSSSSSYQQQTDLTRLARLATVTICNNLSTLLELETYLDQLNLVDEERLRPGWDTYFMTLASLASHRSNCMKRRVGALLVRSKRILSTGYNGTPRGTKNCNQGGCSRCNGTSRGGESLATCLCLHAEENALLEAGRERIGTDSVLYCNTCPCLTCSVKIVQCGVREVVYNQSYSMDELSATVLKEGGVILRQLHMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD10</accession>
    <name>A0A1Y2BD10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleotide binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_523056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD10"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD10"/>
    <dbReference type="InParanoid" id="A0A1Y2BD10"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002132">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="333" mass="35291" checksum="B706EE2FD61782B5" modified="2017-08-30" version="1">MVDSIETPISRRLNSVKNIIIVLSGKGGVGKSSSSVQLALSLLNESPSTRVGLLDLDLTGPSLPRMVGLDLPGASVHQSSAGWVPVYVDQGRRLGVMSIGFLLKDRGDSVVWRGPKKDGMIRQFLSEVRWGELDYLVIDTPPGTSDEHISLLTHLHPLFTPTKSRPTTPSAVLITTPQTTALNDTIKSLSFTRKLALPVLGLVENMSGYVCPCCGEISDCFGRGGGEDMAAKNGLPFLGRVPIDTVLVGLLDAVSKGEVPGAGVEDITMDGGAEANGNGIRSGEVPTTFPLLDRYNGTTSSKVWKEIATGVIGGIEKRRSDILASIEEQQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDL4</accession>
    <name>A0A1Y2BDL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_522408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDL4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDL4"/>
    <dbReference type="InParanoid" id="A0A1Y2BDL4"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="519" mass="58330" checksum="6A2BDD65C715E21F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEV9</accession>
    <name>A0A1Y2BEV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AhpC/TSA antioxidant enzyme-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_478897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEV9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BEV9"/>
    <dbReference type="InParanoid" id="A0A1Y2BEV9"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="189" mass="21205" checksum="CA4A607B2E385480" modified="2017-08-30" version="1" fragment="single">MRELFEASILEVVDEAGASVKFGDLVRNRKTIVVFIRHWFCPLCAQYMNSILAEVSLDALQEAEVDLIIIGNGSAKMLNGYRNKAFKCPFKMYTDPTLALYRKLGLTRQTGNAGPDTDKGAYLIQTPLESTIQTIKRATQMPLRNPGHFTQLGGEFIFDSTLQVSYTHRMSTTRDHAPIRDVCEEAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFY1</accession>
    <name>A0A1Y2BFY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_265157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFY1"/>
    <dbReference type="FunCoup" id="A0A1Y2BFY1">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFY1"/>
    <dbReference type="InParanoid" id="A0A1Y2BFY1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="298"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="508" mass="54468" checksum="CEB89CF368BAB8EF" modified="2017-08-30" version="1">MGQSPSKKMSRTRSKELSTSDLADNLASTHLTPASQATLPRPESTASASSTGASPTSDSLSTPARATASVRKTRNNDRTGSVSSFSSATAGGSSLSVPSSPSVPTTTTILASSPAPSGLRSSLLGSSPPPSATSGSLGRPSSPGPPMSGSQRDSVSSLSPGAALTATISRSSATGSAMGTQVLDIDNMIGRLLEAGYSGKVTKSPPLKNAEIASVCAAAREVFLSQPTLIELSPPVKIVGDVHGQYADLIRMFEMCGFPPQANYLFLGDYVDRGKQSLETILLLLCYKIKFPENFFLLRGNHECANVTRVYGFYDECKRRTNIKTWKTFIDVFNTLPIASIVASKIFCVHGGLSPSLKSMDDIRRIQRPTDVPDYGLLNDLVWSDPSDTALDWEDNERGVSFCYGKSVINAFLATHDMDLICRAHMVVEDGYEFYNDRTLVTVFSAPNYCGEFDNFGAVMSVSEDLLCSFELLKPLDGAALKKEMTKSKRKSLQNHQSPPNNPMAQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGK2</accession>
    <name>A0A1Y2BGK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGK2"/>
    <dbReference type="InParanoid" id="A0A1Y2BGK2"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="428" mass="47883" checksum="214AA1EAFE4254FE" modified="2017-08-30" version="1">MQFSTRNAFYLRVSNYRVIPLFLYLDERHVDWMEDRVLQLVMSELQSKLPPLLTNSRNEKKHKVHVERGEGYQYCYFLRTTTRTEVVLLKNKSYSLRPPTPPPESTPLREQTPKRSRTRSTSTTTRPRSTPTKRARSSRSTSVRSDVESIGSPPLVSEEVQVKDEREETPEVEERGIKDWKPDVNVTFKGFGTSSVQLVLIIEPYPPLPPSEYAPPSSRLSSRSTSIAASRSRSRHFSGTGARSSSTSLSVAPGNSGSRPQSHTPNMRNASRSVSALPRGTSSTPFGREDSSTPGPGGTSGSRRRRASQTPLFIRDLTVDDDEEDEEQHQLYTQALREGRLRLPSVSRPAGIDMGETTSQGRRSVRRGIGLDDDDEDEDDMPETLEAMSQRLVRSSEIEEGVTRVQGGWEERAAGEESAVMGREEPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH15</accession>
    <name>A0A1Y2BH15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_519195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH15"/>
    <dbReference type="STRING" id="71784.A0A1Y2BH15"/>
    <dbReference type="InParanoid" id="A0A1Y2BH15"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31805" checksum="503F010024971EB0" modified="2017-08-30" version="1">MSLPAHLHLLIPSSSSSPSSSSTSNTYLEARLYLPLSRDAYRNDFPISESTRSSPTPYTSLADSLSHLNVKRLITAAHPWSKLGGSMLDPVISYYLLSAVFAHDRDHGQDGHTAVLTFNARGVGKSASAGWFDLGLRTDAEDFAAVERWGAHVLGGVKEIWRFGYSWGSMAALTASPPQTSSTSSSQPRISTMLLSPPYTIFRALTLLAPKSFTSALNVQTQNTNSGTKEGRVWLVYGTTDEFTSVSAYRGLNKEGERTGLVSREIEGAGHFWRGEDGERLELVISEWLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHP0</accession>
    <name>A0A1Y2BHP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_195114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHP0"/>
    <dbReference type="InParanoid" id="A0A1Y2BHP0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="254" mass="28408" checksum="DBBB21C5149D4671" modified="2017-08-30" version="1">MLMGSPSPYGTREAILHDAFQSSACVVRERFHLARRKKNLDPEWKTKTWRFLNFVFVFPPFFLVVVGKPFSPLHFIALTPESLGPHHCNTPSLSFFFIQQGLNSTLNGEHGGASTGLCIERGECESSVAGQRETNKGTTKCSLPESRDIVRYVWSSPHNVPRGFYAAQSCTGEAFAGYSLRSPYLALARRRVGSSTACAENQKIPLPKKKTTCADQVFLPASHRSIHLLAYSLFLLDSFDDTQSRYIAFDHQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI93</accession>
    <name>A0A1Y2BI93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_192950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI93"/>
    <dbReference type="STRING" id="71784.A0A1Y2BI93"/>
    <dbReference type="InParanoid" id="A0A1Y2BI93"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="31624" checksum="B8F4B879D6C15B9D" modified="2017-08-30" version="1">MRLTIRDTKVEVGNYIGDYIARRINSFKPRPDHPNFVLGLPTGSSPLPVYKRLVELYKNGTVSFKDVVTFNMDEYVGIPRDHSESYHTFMFKSFFSLVDITPSNTHILDGEAEDLYKECEDYEASIKDVGGIDLFLGGIGADGHIAFNEPGSSLTSRTRIKTLAYETILDNCRFFNNDLAAVPRMALTVGVQTVMEAREVVLVVTGQNKSLALSQMIEGGVNHMVTASALQTHPWALVVCDEDATSELRVKTVKYFKSIEKVQDEVEAKYGPSGSLRLGLGRASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIP7</accession>
    <name>A0A1Y2BIP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_461866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIP7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIP7"/>
    <dbReference type="InParanoid" id="A0A1Y2BIP7"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="807"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="956"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="957"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="979" mass="107402" checksum="310C9D366494718E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJL6</accession>
    <name>A0A1Y2BJL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_585904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJL6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJL6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42289" checksum="98C0D1016CF8BACB" modified="2017-08-30" version="1">MTTESSHSEPLRLSLSDSSPLTLDLENLTLVNDQLASPLRRIPNELFDMICTYLDSADERTFQSVCWRHRITFWKGIPHVIYPPRGENNSNSKVQPNDDWSLQSMTIDKGRSLEDLPPVTNVDTIYFTDGLINTICRRDGHSFGLPQDFIREWKKWCERNRFVASNAVLSISDLDQGSTQMMAALLSGTGVQHIVITNIHDASIGAFQSLPSWPPMGLSKIDIEMPTIRPGILSETLSNTQRAFLEAFYTAKVLSAIQLAVLGDYSSLRKDGIEKRISNVPKYDPTFPRPPWSKQPPTYQAVSSQDTEGKSLLLVAGPIPKKDELITSEQMAVGSNSGDGKSSSEPMTLRIQVDPNVTDAQRRAAHRRFLVRSNDLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJT5</accession>
    <name>A0A1Y2BJT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_515262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJT5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJT5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJT5"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029704">
        <property type="entry name" value="STEEP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="3">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="183" mass="20243" checksum="8E09BD8563B0D114" modified="2017-08-30" version="1">MPKVVSRAIVSTSEQSKGTQSARAVLRSYYCLCGDFVLVLQGKLDRLPRRRSDGSLIIRAQDGKNGEPARKFKLNAQPGRRCLLKRKGKEDLELRQPFVCSRCNATVAYQTSAPPAGNAPFLYVLRGAMTEMQGRVPFDAFEGEERPPTDTLAINEGQEDNEDEDLDPSYVAEAENQETTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL10</accession>
    <name>A0A1Y2BL10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUR7/PalI family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_509831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL10"/>
    <dbReference type="STRING" id="71784.A0A1Y2BL10"/>
    <dbReference type="InParanoid" id="A0A1Y2BL10"/>
    <dbReference type="OrthoDB" id="3365245at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="604" mass="63182" checksum="F6E9E49161B639CC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLX3</accession>
    <name>A0A1Y2BLX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_512070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLX3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLX3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLX3"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="854" mass="94422" checksum="0DEFD29DBDC0909C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLZ8</accession>
    <name>A0A1Y2BLZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_512198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLZ8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLZ8"/>
    <dbReference type="InParanoid" id="A0A1Y2BLZ8"/>
    <dbReference type="OrthoDB" id="2563380at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="735" mass="82402" checksum="3380118C836FF8FF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMH5</accession>
    <name>A0A1Y2BMH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_555931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMH5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMH5"/>
    <dbReference type="InParanoid" id="A0A1Y2BMH5"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="249" mass="28193" checksum="720D5CE97740D4F4" modified="2017-08-30" version="1">MSATFSVKNIFAQTWQRYLVALRERPLRTKMITSGAMYVGGDCVAQFGIEGRRIDRDAPAKEQWDPVRTIRLTFYGGVIFAPLAHHWIGAVDRIRLSSRVGTLLTRLATDMLIWSPFVCTLFPSSLGFLEGKNLEEVKQKVQMSWFPTYTKALSVFGPTQVINYAFVPVQHRLLLLQGVGLCWNIFLSWQNNLTNHRMAEAALHLAMASTVEEKEEAREEMREAEKKREEIRGAEGGGEVGVATRLSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AC99</accession>
    <name>A0A1Y2AC99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Calycin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_555433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000145">
        <property type="protein sequence ID" value="ORY20199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AC99"/>
    <dbReference type="InParanoid" id="A0A1Y2AC99"/>
    <dbReference type="OrthoDB" id="4415004at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008729">
        <property type="entry name" value="PA_de_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087:SF1">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05870">
        <property type="entry name" value="PA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY20199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="175" mass="20271" checksum="BBBD76092F562698" modified="2017-08-30" version="1">MIHPNDPKVKAQWEKDIGDVHLLYDYNAKNPETGADEKWRYEMWFSHEDRITYAIHGGPMAGRFNYQKADYQCIRPGELWQCNWLEETGTICSLVYDIPNKRISTLLGFSHGHWYNPEKAHGDKRNPEDFARWRELAKEGKSQSDRFMLNEQADIVEAFKGAGDLAPIDPTAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE33</accession>
    <name>A0A1Y2AE33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_554787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000124">
        <property type="protein sequence ID" value="ORY20838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE33"/>
    <dbReference type="FunCoup" id="A0A1Y2AE33">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AE33"/>
    <dbReference type="InParanoid" id="A0A1Y2AE33"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="235"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY20838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="687" mass="78535" checksum="12624D88D8468BC8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF90</accession>
    <name>A0A1Y2AF90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_554247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF90"/>
    <dbReference type="STRING" id="71784.A0A1Y2AF90"/>
    <dbReference type="InParanoid" id="A0A1Y2AF90"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY21112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="296" mass="32061" checksum="308CF85CA9A0DB90" modified="2017-08-30" version="1">MTLSLCRSLVRYGIVRSRRALSTAPPPQAYLHPLALDPSDPRAEELQGVMLLSMDREKARNALSRQMVAEMREGISKASSSSSTRLLLLHSAHPKIFCSGADLRERTTMSPSEVSTFLDSLRSLMGELEDLRIPTIGVVDGFALGGGLELALSCDLRIGGENSVLSLPETKLGIIPGAGGTQRLTRLIGPSKSMELIYTGRRVGPVEAEKIGLINLFAQPPQTPLKASLNLARQILTSAPLALAAAKRAIKAGDTLPIDQGLDLERELYDPLLVTEDRQEGLKAFAEKRRARFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFC6</accession>
    <name>A0A1Y2AFC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_591651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000117">
        <property type="protein sequence ID" value="ORY21152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFC6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFC6"/>
    <dbReference type="InParanoid" id="A0A1Y2AFC6"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16106" checksum="D901E0A5C0452CAA" modified="2017-08-30" version="1">MGIKTSIISNADPRILKTLSSLGILELLTHAPTLSWDVEASKPDSRIFQAACKACDVVDIGQGVIMVGDELKALQIYSVQADLGIGSDYRGARAAGLEARLIRRQGDWSDGAVREAEEDLEDVDVVTSLDDVLEEVRQRNRLKGDIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFJ0</accession>
    <name>A0A1Y2AFJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_553814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000113">
        <property type="protein sequence ID" value="ORY21329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFJ0"/>
    <dbReference type="FunCoup" id="A0A1Y2AFJ0">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFJ0"/>
    <dbReference type="InParanoid" id="A0A1Y2AFJ0"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="57" mass="6577" checksum="7FCFC26ADBF38C79" modified="2017-08-30" version="1">MAKKTRDRRIIIKLVSTALTGFFYTTTRVRTAAKMSMMKYDPRVGRHVLFVEGGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH38</accession>
    <name>A0A1Y2AH38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_552700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000102">
        <property type="protein sequence ID" value="ORY21908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH38"/>
    <dbReference type="FunCoup" id="A0A1Y2AH38">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AH38"/>
    <dbReference type="InParanoid" id="A0A1Y2AH38"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="98"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="32733" checksum="3811BAEA423E9914" modified="2017-08-30" version="1">MATKDPLSGHPGHLDAAQQSALEQFRKELLAEGLIPEDREAVAKRLGYDRYDDQTLLRFLRARKFDLPKSKIMWEGNEKWRKEFGTDEIAANGFHYPEQVEVNKYYPQFYHRTDRDGRPVYVEQLGYLDMNKIASLTTQDRQIRHLVHEYERFLKDRLPACSEKQGEIIETSCTIMDLNGAGISTFYRVKDYVSAASNIGQNHYPETMGFMFIINAPYLFSTIWSLIKPWLDEATVRKIHILGKGYKAELLKYIPETSLPTDLGGVCKCPGGCTTSDAGPWNPANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIM1</accession>
    <name>A0A1Y2AIM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BCR39DRAFT_551574</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AIM1"/>
    <dbReference type="InParanoid" id="A0A1Y2AIM1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1234"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1629"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1656"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1684"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="21"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="990"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="21">
        <location>
            <begin position="1981"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="609"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1900"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1923"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORY22433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2050" mass="229272" checksum="E92394497329A77F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ10</accession>
    <name>A0A1Y2AJ10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="14" type="ORF">BCR39DRAFT_551283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ10"/>
    <dbReference type="FunCoup" id="A0A1Y2AJ10">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJ10"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ10"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY22568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="200" mass="21986" checksum="8F75CFB48F1A9B6A" modified="2017-08-30" version="1">MSTKPSSSDPTSLLITVGSTLFPELTSAVLTRAFARILVDAGIKRLVVQYGKAKLPWELIMRLDLAVDALGQAERTVRPFDSDDGEDEREIHFQVKRFVDDFDGVVASVDAVISHAGSGSIMTALRNGKKLLVVPNTSLMDNHQAELADVLNAQGYLTVSSVDELYKAVPGWLALQDRLREFPQQDPTIFRRVVDEVAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJG4</accession>
    <name>A0A1Y2AJG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_508064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000090">
        <property type="protein sequence ID" value="ORY22634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJG4"/>
    <dbReference type="InParanoid" id="A0A1Y2AJG4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="209" mass="22975" checksum="87C0A78ED3F418C1" modified="2017-08-30" version="1">MADWMLDTSGPGNQIIQPQSYQRPINSTDRHLPQHPSQFAFSRQPTAGPSRIPDELAAPPYGYTDTSPQYRSILFSLGSAKQAVPHGRCETKNADDPRLDECRPVSIPAAEGCLSMTAGESQISRGEEPQYPNSSLEPSQQGQQLERSRSVEDQSSFQSSMLEQQAQRNAAESHQIQQFVWDSHSDMFLPVTSDGRKIKAESPGVGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKF7</accession>
    <name>A0A1Y2AKF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Retinal pigment epithelial membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_501168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKF7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKF7"/>
    <dbReference type="InParanoid" id="A0A1Y2AKF7"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="794" mass="88584" checksum="BCE23872CB4B7680" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMA8</accession>
    <name>A0A1Y2AMA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_590922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMA8"/>
    <dbReference type="FunCoup" id="A0A1Y2AMA8">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AMA8"/>
    <dbReference type="InParanoid" id="A0A1Y2AMA8"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="318"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="569"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="658"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY23636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="729" mass="78190" checksum="34B52CE306148024" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMN2</accession>
    <name>A0A1Y2AMN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_362763</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMN2"/>
    <dbReference type="FunCoup" id="A0A1Y2AMN2">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AMN2"/>
    <dbReference type="InParanoid" id="A0A1Y2AMN2"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="12">
        <location>
            <begin position="15"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="204"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="208"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY23205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="505" mass="56130" checksum="8F314C5A02311C2D" modified="2017-08-30" version="1">MEDEVEVQCRILQEEEITALESIYPSQIVIQPNLTGKPGHIVTLTVPVSLSSPITAQLSSISQHASSSSLLPSLELSHLPPIEIRLFLPPSYPLTTPPKPITSRAPVPTQDGGHSSYLSRKSLGKIQEKLREMWKEDKELVGEGAGVLWRWWEWVASGDFFSDLDLLKGDTLELSVPPLIAPSTFHTSLKTYNAQQLHSSFESTAFSCSICMENRKGKSCIQMPGCNCVFCAPCLASCWSLAIEEGTLENVSCPSVTCVKQRATRVPGPASQLSNAGETDPDLVESVVGKELRDRWQELKERRRAEIDPTFTVCPRPTCQAAVPPPPLPTAADLASQSANSNRAIRLSDLGRPTPPSPPKSAQPVIAEDRWARYRSCPKCQYSFCLYCSATWHGPHTLCAFPQTSLIVQEYLSYPEGSEQRRLMELRRGKANLERMVTKWREDEENKKWLESRTRACAGCGVRVEKSHGCNHMTCGRCNAHFCYRCGSSVSSLSKLSPYRILFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANI9</accession>
    <name>A0A1Y2ANI9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_336918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANI9"/>
    <dbReference type="FunCoup" id="A0A1Y2ANI9">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANI9"/>
    <dbReference type="InParanoid" id="A0A1Y2ANI9"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001135">
        <property type="entry name" value="ABC transporter F family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="182"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="512"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="265"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="729" mass="81062" checksum="088C0C83E8CD6F22" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANN3</accession>
    <name>A0A1Y2ANN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_566686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2ANN3">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANN3"/>
    <dbReference type="InParanoid" id="A0A1Y2ANN3"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="305"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="537"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY24122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1340" mass="143375" checksum="6F78AB5202820538" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANS4</accession>
    <name>A0A1Y2ANS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_561682</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANS4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANS4"/>
    <dbReference type="InParanoid" id="A0A1Y2ANS4"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012214839" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="406"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY24136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="820" mass="90679" checksum="ABBAD2BE81F5CC31" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APR8</accession>
    <name>A0A1Y2APR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_547332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APR8"/>
    <dbReference type="STRING" id="71784.A0A1Y2APR8"/>
    <dbReference type="InParanoid" id="A0A1Y2APR8"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="111"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="247"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="694" mass="74290" checksum="3A1DDA5B601186FA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQB3</accession>
    <name>A0A1Y2AQB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALA1</name>
        <name evidence="15" type="ORF">BCR39DRAFT_545772</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQB3"/>
    <dbReference type="FunCoup" id="A0A1Y2AQB3">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQB3"/>
    <dbReference type="InParanoid" id="A0A1Y2AQB3"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="14">
        <location>
            <begin position="23"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY24753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="975" mass="107899" checksum="C782C0A4E2F9BB9F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQC4</accession>
    <name>A0A1Y2AQC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_545879</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQC4"/>
    <dbReference type="FunCoup" id="A0A1Y2AQC4">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQC4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein-macromolecule adaptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
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        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
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        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="308"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="391"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="442"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="711"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="986"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="833"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="882"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
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            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="986"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY24778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1143" mass="124698" checksum="C4427D526E40F12B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQW4</accession>
    <name>A0A1Y2AQW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_581346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="41"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="495" mass="53006" checksum="9E1C2E06E1414B37" modified="2017-08-30" version="1">MDSEKSIDKSDEAQIAVLPGGDHASSSKYEPQLKRQMKPRHVSMIALGGTIGTGLFLSSGNALANGGPLGLVLGYALIGFVCFCVMTALGEMIAYMPIEGGIITLANRIVDPAFATALSFNYAYCYLFILPAEISAAAVLINYWITSVNNAVWITIGIVLVVGINLMGAKFYGETEFWFASIKVLTIVGLIIVSIVIDCGGGPASSGYVGFRYWKDPGPLNQYAGIAGAGGRFLGFWAVLIQAAFSFIGCETIAMTAGECKNPRRTISRAVKSIYVRIVLFYVLGMFTMGLVCPSNDPRIGTSSDAGASPFVIAIDIAGIKVLPSIVNACLLTSVLSAASADIYISSRTLYGVAKNGDLPKIVMKTTSRGLPIVAISISVCFALLSYMAVSSGATTVFNWFACAMAGITSWFSICVMYLRFRRALDAQGINRADLPYRGPITKFGCYFALVVIFLTSLTSAWSVFLRGNWDTATFVTNYLPMVLFPILYVAKKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARI3</accession>
    <name>A0A1Y2ARI3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_590346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARI3"/>
    <dbReference type="InParanoid" id="A0A1Y2ARI3"/>
    <dbReference type="OrthoDB" id="10657330at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="372" mass="43017" checksum="F8BC6455A5BAA5D0" modified="2017-08-30" version="1">MSYSIATSGRTRHLNMLHIDLDCRSPTYRTAATLPIQPHEYDPRMVAIGTWRLPQSLFGAGEMLWRLWDVAAPDERDEPGFLRDLTKRTEITIQDRVNEAGVIEKFINLGQERKDIMDSETERRLRHETFCSAQTWIYLRGKEIVMRQLHVVYLAEDFLLREPYSGLSSSNRPSTLLWRNKKDAKLDYLNEQVSLAQSTRSQAERYLSEGDYYQAAQKALIGLAILAPWYPLELYMPQWEADLTGLLPVVVDLNCILAQSMSSLKDHLTVISISRTFQHHPFLNAGQRNAFMQMEFRALMTNLRALEMDEDPSRRLENAASIWIKRDRMGRLLRFTNWVAAFIKASALVSEGADFEPEQILDAEKRFRETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARQ0</accession>
    <name>A0A1Y2ARQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_561162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARQ0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARQ0"/>
    <dbReference type="InParanoid" id="A0A1Y2ARQ0"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="76"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="283" mass="29675" checksum="98C1897D403AEAFC" modified="2017-08-30" version="1">MDAPADTPISGERINEERAFIKRYTEGLAAHKVEYPADYSTPLEDRPRKVAAVGVPLAEPPDVMDVDVGPVQDSSVSVTVKSLKPPLSFNVTAQLTDTVADLKTLVSKSSSSAPSPDSQRLLLKGKALIDTKLLKEYDIESGATIHLMVKASTPAPAPPPAPAPHKPSHASSASIDGPPTLTITTSVDASSSPGTEMPLTNMDTSAPPLGPQPQVSSAAFHNTVADPQFWQRIHALCVGSFAYEDDADAAWETFLISMKGRLSAGEAAKIRDVVGVRGMGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARR0</accession>
    <name>A0A1Y2ARR0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARR0"/>
    <dbReference type="InParanoid" id="A0A1Y2ARR0"/>
    <dbReference type="OrthoDB" id="3357948at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1253" mass="134519" checksum="72043C4E08386887" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS98</accession>
    <name>A0A1Y2AS98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_580176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS98"/>
    <dbReference type="STRING" id="71784.A0A1Y2AS98"/>
    <dbReference type="InParanoid" id="A0A1Y2AS98"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="81"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="393" mass="43870" checksum="EF1E33F625076E42" modified="2017-08-30" version="1">MPIAIQEPGGRELVILPPATTQARLSKAGIDISKGYPFVPKHAPEFVSEVYEIRKELRQYVDPATRADPQKRALFGAAKEVRHIGVHLGTEIVGLQLKDLTNQQRDELALLVAERSVVFFRDQDISPQQQRELGVYLGDGEIEIHPNYPQVPGLGGGLSLIWPEGHTEGGRSLARLQRNFRLPYGSGVNSPYGWHTDLVHEAFPPAYTHLHQDAIPEIGGDTLWASGYAAYDKLSPKFRTLIDGLNGIYRSANAYKDDKDPNGPLKYVTRVHPLVRTNAATGWKSLFVNRAFTVGIQGLDKSENLSDAILNHLLDVYERSTDIQVRWQWTPGTSAIWDNRSTIHTVSLDWEGWNNRHGTRVSSLAEKPYFDPQSQSRRDALNLGDYLGVPGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASG7</accession>
    <name>A0A1Y2ASG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="5 10">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_544592</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 10"/>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASG7"/>
    <dbReference type="FunCoup" id="A0A1Y2ASG7">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASG7"/>
    <dbReference type="InParanoid" id="A0A1Y2ASG7"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY25240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="201" mass="21837" checksum="7E04B568D0AFAACA" modified="2017-08-30" version="1">MDARSATVARDTSETQITCTLTLDTEPTAKQVIDVQTGIGFLDHMFTALAKHGGMQLELKCSGDLHIDDHHSAEDCALALGEAFKKALGERRGIKRYGFAYAPLDEALSRAVIDISSRPFFVCHLPFTREKIGDLSTEMIPHLLQSFAFAAGVTLHIDYIRGENNHHIAESAFKALALAIRMAISRTGGDDVPSTKGVLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT04</accession>
    <name>A0A1Y2AT04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_544353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT04"/>
    <dbReference type="FunCoup" id="A0A1Y2AT04">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AT04"/>
    <dbReference type="InParanoid" id="A0A1Y2AT04"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="101"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY25337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="506" mass="54934" checksum="3EFA1ED5147B4865" modified="2017-08-30" version="1">MSSAMNPLRPLLRSAIRRASAPVSSARMARRTLVTPTNINHAQVSDIQVNATQGVREDPGEFDEGDVIASESQSGEGMFGFKLNPVATKTGGHAKSEGRPIYLDMQATTPMDPRVLDRMLPFFTEQFGNPHSRTHAYGWEAESAVDEARKHVASLVGAHEKDIVFTSGATESNNMIVKGIAKFYQKSGRKHIVTTQTEHKCVLDSCRYLESQGFEVTYLPVLPNGLVSLSELRAALRPTTTLVTIMAVNNEIGVIQPLKEISDTIRSWAKENGVTKPFFHTDGAQAVGKIPIDVEAMGIDAMSISAHKIYGPKGVGAAYVRRRPRVRLEPLIHGGGQERGLRSGTVAAPLVVGMGEACRIAMEDMPADHARIKVLSDRLVKGITSQVDQIVRNGDPSGYPGCVNLSFSYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGAADDMAHSSLRFGIGRFTTEAEIDLVIDRIVSVVNRLREMSPLWEMVQEGIDISKIEWAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT94</accession>
    <name>A0A1Y2AT94_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_543064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT94"/>
    <dbReference type="InParanoid" id="A0A1Y2AT94"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="81" mass="9392" checksum="487929B1E71B836B" modified="2017-08-30" version="1">MSKASSDMSQVQLRAEQEAPWFILQQMTGYSIRSPLRFSTRCSVSCRQLALAFPPILKWTTMIAVGFNIFCRQIHRPRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUL5</accession>
    <name>A0A1Y2AUL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative negative regulation of transcription by glucose-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_261538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUL5"/>
    <dbReference type="FunCoup" id="A0A1Y2AUL5">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUL5"/>
    <dbReference type="InParanoid" id="A0A1Y2AUL5"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="268" mass="28321" checksum="02AC95A74BF688C3" modified="2017-08-30" version="1">MRKGAGISALSRHAATNSSYSALSNTISASQLSTLETSLSSFKAALLAFASAHRDDIRSDPAFRHQFQKMCAAIGVDPLAATGSGSGSGSSGGRGIGGWWSDALGLGEWQYELAVQVVDICVSTRERNGGLLAIDELVKRLTSMRGGVGAGVVTAEDVSRSLILLKPLCAGYSTHTIGGIKYVRSIPRELDTDQSLLLILANDTGGKLTEDTVKAQTGWSDVRVRTAMDDCVMREGLGWIDQQAPGGRDVWLIAAVDMSDRDKGSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW83</accession>
    <name>A0A1Y2AW83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ribosomal protein subunit L20-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_540559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW83"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW83"/>
    <dbReference type="InParanoid" id="A0A1Y2AW83"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24587" checksum="EC784C12A35A051C" modified="2017-08-30" version="1">MASLASSSRLGLTSSPFTPLGSLRLKHGGNLRWQKNRPKPPRIPKLYSPHTPKPILPSSGTSQPHPPHLLAPDDYVPPTTASPLENGMTFHHSPPPSAPSYTTGVVPPMLKWLGGESIRLSGEEAAPLLRHRKEPIAGKIHQWGEETVARMKELRAQGMSTKSVVEQLGLTEEDRVLVARVAPLSKEQQAVKEAELQETKDLWGYRKRLARESRVVRRTYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWF3</accession>
    <name>A0A1Y2AWF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_470536</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWF3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWF3"/>
    <dbReference type="InParanoid" id="A0A1Y2AWF3"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY26235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="923" mass="103143" checksum="2DF5376C6708C817" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWZ6</accession>
    <name>A0A1Y2AWZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_469740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWZ6"/>
    <dbReference type="FunCoup" id="A0A1Y2AWZ6">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWZ6"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="503" mass="54124" checksum="E3564FCE24C27821" modified="2017-08-30" version="1">MPPREETASQEESSSLKIPVSPSAPTSVVALALTPAQIAETGSVSHPDDPLNWPVSRKWIVTAALSISGFNRIVVSTIMAPALPVISRELNLTTIQSTAALGAFVLATAFSPLILGPLSEVYGRAPVLHITNIWFFAFNLACGFVDTGAGLIASRLLAGFGAGAIFALASGVLGDLWSPEQRGATLSIYLLVPLLGAGVGPIIGGFVEQYTTWRWMFWSTSIMQAFTVTVCLIWFRETHLPTLKTRRSNINNETPSSSWRKPFSQLPPIPGQLLRKSFSTPPKQLLLHRSVQLQAALSGFGYGILYLVLSTFSSLFTSNYNESVSVSGLHYIALCLGEIVGSQIGGRLMDYLARKAKKITKSDRFQPEFHLPIIVPGAVMAAAGFLMYGWAAQRRVPWIVVDIGVFILSLGLQMTGQGLQAYNMDTYPDSRASTSAAIQVFRSLGAFALPLAGPKMYSSMGYGWANTMLGSIYVGGHVSGAAFLWKRGAALRAASDPVPLEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX61</accession>
    <name>A0A1Y2AX61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_538730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX61"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX61"/>
    <dbReference type="InParanoid" id="A0A1Y2AX61"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY27173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="536" mass="59962" checksum="46D558C50D537203" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY22</accession>
    <name>A0A1Y2AY22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mannose-6-phosphate receptor binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_594461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY22"/>
    <dbReference type="FunCoup" id="A0A1Y2AY22">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AY22"/>
    <dbReference type="InParanoid" id="A0A1Y2AY22"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000479">
        <property type="entry name" value="CIMR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00878">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="308" mass="33391" checksum="5ACCA5AF40F66E47" modified="2017-08-30" version="1">MSADTPCTLTLADGTHYDLSSLASAKADYEAKVGETSYKLNVCRGVVSELWHLDDAENVGGFVSRQGGDFSLGRVNSTLYLSPASNEPMLYIQNGSPCPHNSDELASTAIRFICSPSDFHAGTPILVAALPPDDPSRTCHFFFEWSTHVACPTNAKAQLGTSHYVAFGAILFIAFLTWFGGHTIYNRFYLKRRGLDQFPIPKISLPSAPALSFRSDGQSTIPKPGGFWKRRSQRNGYTNIRADDNDEHEGFAGRFSLEEDDEDAEDLTGGGVDARALGGETHAWRGTARGDSQQGHASVGVHQGLVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYK6</accession>
    <name>A0A1Y2AYK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chaperone regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_538313</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYK6"/>
    <dbReference type="FunCoup" id="A0A1Y2AYK6">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYK6"/>
    <dbReference type="InParanoid" id="A0A1Y2AYK6"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012101469" description="Chaperone regulator" evidence="8">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="141"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41408" checksum="91D8E567560DFB1E" modified="2017-08-30" version="1">MLPATLLWVCSLCLLTGCLAAQSFYSVLGIKKDATDVDIKKAYRKLSKKLHPDINPDESAHHKFIEVSRAYEVLSDSETRTIYDRHGEEGIKQHEAQKQNGGRNPNDIFSRFFGGGGQQQQQRGPSMLTNLEVELSDMYTGRTVEFQIPRKVICTHCHGSGAHSDADIHDCDQCGGQGIVVQRHQVFPGMFTNVQMTCNHCGGKGKRIARSCPTCDGAKVLDTLHTLAVHIPAGAPEGFEEIFHGEADEGMDWEAGDVIVRVRSRRLEGQAVWARKESGLIGRVTLSVAEALLGFDRTLTHLDGRTIALGRRGTTQPGEVEVIEGEGMPAFGDVLQGDMYIEYSVVLPTEVSESSRQKLLDIFEHPSNHNRKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYL7</accession>
    <name>A0A1Y2AYL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_223769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYL7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYL7"/>
    <dbReference type="InParanoid" id="A0A1Y2AYL7"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32961" checksum="A45074653164FECF" modified="2017-08-30" version="1">MEQESPIIVNIPVLSEGSTEEHTSSAPLDVVEAHHAGQDDSFVEKKATPELDQTTSPKERKMHESYNEGDFTLISSDDVAFKLPKYQLLAMSVVFRNIFQIGIDTTSEISLDDETIEDSSTLCLVLDLAQGKGSFDVARLATYSPSANGRSVTPAALGMIRQVMGFIAKWDCPMVALVIRHIHSSLATSGEASVHELFRHGAMMYEPDICAMAIRAAALRPRFLTEPSEARLLTDQIAKASVFDVVAWRLGEFETVPPKYILALLRATRLCDFTRGAKLDWNAIADEFVRLVNTANTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYU1</accession>
    <name>A0A1Y2AYU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_506195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYU1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYU1"/>
    <dbReference type="InParanoid" id="A0A1Y2AYU1"/>
    <dbReference type="OrthoDB" id="2409325at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="566" mass="60263" checksum="D3C58A08BF70A065" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ28</accession>
    <name>A0A1Y2AZ28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_242700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ28"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ28"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ28"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="74"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="296" mass="33605" checksum="0D56C8D6E95B66DC" modified="2017-08-30" version="1">MPKISSILAASNESALRLCLEATLYRPTYSDSFLCLTQPTQVQSFPVSSPPLDRHTVFYARSAFSFAILTIWTPIIIRTYELTLRQQPMQALLCKDVEKSEHWLIDPTPVVRLRILNSKSEDIAKYSPYIRDYTHAGNQEQHGEPIARPCGTSAAQNPFYILQARLVRGEPEHDPHFIDDGLTEFLTGTPVSSLYHRKDTDNTEAAYFVFPDLGVRIKGRHKLKMTLFAIIGQEVCYCSSIYTSTFIVIPAKQLPVLYHRISFMRPGQPGTKVKSRRKCQDHFQGSKTLPSHRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZL1</accession>
    <name>A0A1Y2AZL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_212975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZL1"/>
    <dbReference type="InParanoid" id="A0A1Y2AZL1"/>
    <dbReference type="OrthoDB" id="2553298at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="119" mass="13092" checksum="82204D6294D2A4F7" modified="2017-08-30" version="1">MPKNPTKNDLKGLTYIAQKPKFLQNFGQAPTSPPPSRSRSHGREREPDGLPSRPKEGKWAGGSDDEGGGKGRESDDDEWGETFGGGGDDGPQVVVLKEGRHLTADEVKRERRRGELLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZQ2</accession>
    <name>A0A1Y2AZQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_536430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZQ2"/>
    <dbReference type="FunCoup" id="A0A1Y2AZQ2">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AZQ2"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="351" mass="38650" checksum="8F26B75C7C36A287" modified="2017-08-30" version="1">MSLIPTDSQRLVLHKRPERGPVTDETFSLESISIPDLKDGEVLVRVEYVSIDATMRNWLNPTRSYMRPVEIGEVMRAGGIGRVVASRAKGFVENDLVFGTLGWQEYWLGPAKHLEHRQTPRGGKDIDHLGLFGISGMTAYFGIFDIGRLKDGEKVVISGAAGSVGLIVTQIAIAHPKCTVIAIAGTPDKCAELEKLGCHTVLNYRDPNFRKAFKKVGLIDVYFDNVGGEILDMVLAQLNPHARIVCCGAISQYNAKTPYPLTNTPSLIAMKASMTGFIAFEYAARYSEATTYLAELQSKGSIKYEYHLLEPRQGERNGLGRCTEGMEVVYQGKNYGKTLVKISGNQQSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZS3</accession>
    <name>A0A1Y2AZS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_537331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZS3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZS3"/>
    <dbReference type="InParanoid" id="A0A1Y2AZS3"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="65"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="275" mass="31056" checksum="31D9AF734612F32C" modified="2017-08-30" version="1">MLWRVSRCSAYCTTKTMGYRRYAQPAFAEESSSSDASPSIRSRKGKERDSGYRFPTIGKRGGPPNPYEILDLPESASEKDIKQQYYRLALILHPDSTHPSSSTDHFADLNRAYTLLSSPSSRKLYQQTGHGWSQAGPATAQDLADAFMKAELMRRARGGAARHQRRYSEAGSGAFFDAEPLQGDGEPRYMSNPSFLSVTIVFSTVMAWVQYHRWKMEADTHKEVLDTAHLNAASNLAHARQEAISVGHQRREQIRRKVREQQVIQELDELQGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B011</accession>
    <name>A0A1Y2B011_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_538051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B011"/>
    <dbReference type="FunCoup" id="A0A1Y2B011">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B011"/>
    <dbReference type="InParanoid" id="A0A1Y2B011"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="31"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="135" mass="15107" checksum="4B6A66A6F1C89674" modified="2017-08-30" version="1">MSRLSSITRGIPSGSRMTRRYFSSSRVARDHILNTDAAGFRARALDETQSKPVLVDFFATWCQPCRMLTPTLKNLTGPESQYDLITIDVDEHPEVAGQYKVSALPTVVAFKNGKPVNKFVGMLREEQVKTFLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B173</accession>
    <name>A0A1Y2B173_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_198118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B173"/>
    <dbReference type="InParanoid" id="A0A1Y2B173"/>
    <dbReference type="OrthoDB" id="2575658at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="105" mass="11802" checksum="002B467D92F73E2F" modified="2017-08-30" version="1">MKFLSCLSSPNPIPIQTHTQSSPLLADVGKPVKPGCIFCSVSSQNGFNIVYEDQELIAFHDRSPQAEQHLLIIPRYHLGEYPNVPSMQLSYAFPVSRYRVVVIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1E4</accession>
    <name>A0A1Y2B1E4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_588985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1E4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1E4"/>
    <dbReference type="InParanoid" id="A0A1Y2B1E4"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF351">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE PVG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="439" mass="51116" checksum="479D890DF96EF262" modified="2017-08-30" version="1">MHLPLPSLALVRRRILQYPRLASLIAIWLAISLPYLILRHIHHGKHGRWYWNYAAALHPALIYVVPSGNWGPIERPPRWVQEIYDAPWMGDWEIPELSAPVYRQGPATAAKEEHANLFNVSDPSRDLVSPVIVKIHVFSTVRSEAREKRFLIRRLSPLLNIPLPYRHLIELKFVLGHAYKPNWDVDEEMEALLTEEQETYGDLLRLNLVHGENLREGKILDWIHAVGSGNDGGREALWLFKVDDDAVLNLPVFLDTLLELDPHLPHYLGTSLNRWPAYHHHFTGMVTGFSWGLVKTLSSGIGSMTRQEIETWWDDDVLTGELMFCLPPAPHCREPNRSSLSLHHSTEESLPEYCDPRAPPPWGWLAPPPSPDPRTNLIRYDFLRRMGDEVIWFIKGDVARHSWWFKFLERYEKEWKTRIKGKMWTPPKWLERYVDRNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B231</accession>
    <name>A0A1Y2B231_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_533916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B231"/>
    <dbReference type="STRING" id="71784.A0A1Y2B231"/>
    <dbReference type="InParanoid" id="A0A1Y2B231"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012011052" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="153"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="955"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1045" mass="111355" checksum="9AF8D7B7090E6836" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B353</accession>
    <name>A0A1Y2B353_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_481921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B353"/>
    <dbReference type="InParanoid" id="A0A1Y2B353"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C19D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <end position="181"/>
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            <end position="612"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="679" mass="72513" checksum="79B2D050B558B351" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3V0</accession>
    <name>A0A1Y2B3V0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_169024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2B3V0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="252" mass="27192" checksum="CE37509D39F2B8B1" modified="2017-08-30" version="1">MAQSQVSSLMVSCADTVQSIPKTIVVEGDTYYWMEAHTGLPVSLRSSGWELEQRDFEGVAYFKLTSIEVDTTLGQEVPESLDATGSGGPTLQPDREDHPERGEASTMANAETPPTTTQINLPSLSKKAVASIALVLVTTVLLGRFEDHLSHSTNWNVKLGDFDGLQARFEKAKKEFAVLSKGPEKLSGLAKLYHKSGDALRVLGDDLRDTGFTPDDSIAWTCFISLGLSGPLGRKVAAAGMGALAMKRAFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3W9</accession>
    <name>A0A1Y2B3W9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_454830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3W9"/>
    <dbReference type="FunCoup" id="A0A1Y2B3W9">
        <property type="interactions" value="833"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3W9"/>
    <dbReference type="InParanoid" id="A0A1Y2B3W9"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="378" mass="42264" checksum="ED9F654C70D83C6E" modified="2017-08-30" version="1" fragment="single">QASSVAQVDTIYSADSIEWCPHSPYRDIFTCGTYQVLEPEPTAGPSSSSSSTEVPKREMNRTGRLYLFQVGNDQQTLEELERIDTAAVLDVKWSPRLDPLGQAVVAVADAKGWITIYALNNDKRLHLKQRLEIASSSTLCLSIDWSTHQNEDDFVLPNLIVSLSDGTLAHLTATSTGELEVDQQWKAHDFEPWITAFDPWDPHVIWSGGDDCKLKRWDLRSTSFPTLVNKSFEAGVTTITPSPHTPYLLAVGSYDAQLRIFDSRNARSPLRTIDVGGGIWRTRFHPDIKRAGDVLVACMHDGFKVVRLGSETDLARILVLVDEQQDVGDASQIVTRFDEHASLAYGADWSRLSSDDHDDKSTLVATCSFYDHSMHLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B454</accession>
    <name>A0A1Y2B454_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_559038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B454"/>
    <dbReference type="STRING" id="71784.A0A1Y2B454"/>
    <dbReference type="InParanoid" id="A0A1Y2B454"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="123"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="645" mass="70310" checksum="B84CE0F89029CA2F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B571</accession>
    <name>A0A1Y2B571_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_564983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B571"/>
    <dbReference type="InParanoid" id="A0A1Y2B571"/>
    <dbReference type="OrthoDB" id="2561529at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="171" mass="17440" checksum="EF52862620F75CD0" modified="2017-08-30" version="1">MATGRATPFLVAAGIGVVSGVYIWNKPLQELTGHSPAPDAIKDGRSQTVKDGGDKDGSPSSGGPHTALRYGGSSLTSKDDAPSVAGTSPESRKGYSADHDIKTRSNAKEQDGSSGGGVGVAEMRERKMEGRGLPSPQGGDTKPKPVAAATNDGEGGGIKPKANGRWWLGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5E0</accession>
    <name>A0A1Y2B5E0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_530679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5E0"/>
    <dbReference type="FunCoup" id="A0A1Y2B5E0">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5E0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5E0"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="299"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY30023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="768" mass="85707" checksum="06A821FE710171B5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5U8</accession>
    <name>A0A1Y2B5U8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_505231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5U8"/>
    <dbReference type="InParanoid" id="A0A1Y2B5U8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="24248" checksum="F06D9B35FB482DE8" modified="2017-08-30" version="1">MSRTRAPSTTTREQTSGQPSTVSTSSQRLPKRTAFDTIKETFGGTSDRRQAKIDSARADMERWSQPFKTDSTYDSRKDTADEVYLLLHRRPKSTIGSAHFVPLKYYVEELVNRPKAWGATVSQSDADIERLQKVSRFLEPGIQPSGERAALGIASLLRESLHQDENQCAELHGFLSSYVTKNEGTFASRNWEELGLYGLRRQEVATRARTAASSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B657</accession>
    <name>A0A1Y2B657_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiosulfate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_529805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B657"/>
    <dbReference type="STRING" id="71784.A0A1Y2B657"/>
    <dbReference type="InParanoid" id="A0A1Y2B657"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="170"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="295" mass="32428" checksum="293527967CC6FCA7" modified="2017-08-30" version="1">MSPFLVNPSSPLLHDPLTVLLDGTWLYRPAPGTPTPLESYRTRRLPKARFWDYDAVAGSNPLGLSHMLPDPEQFAQYVSELGISGDSKVIIYDGVGSMSSCRVAWIFTIYGHENVSILDGGLGRAVDEGLALEFGEPSVWTTTNYPVPTLRQQYLSSYEDVLAYSQLPSTPAKTFLIDARNAESFSTSPGHIPNSLNLPWRTFLATHSASNEVTKQWIGKSWSRLPQGEDLVSKLEGGLGSQAAEAVLQDNAVVINTCGAGISACILWAALRSRDIDSKVYEESWEGWSKRHPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6U1</accession>
    <name>A0A1Y2B6U1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_505084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6U1"/>
    <dbReference type="InParanoid" id="A0A1Y2B6U1"/>
    <dbReference type="OrthoDB" id="2572819at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="639" mass="67450" checksum="4AEB848627037C71" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7F0</accession>
    <name>A0A1Y2B7F0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_528210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7F0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7F0"/>
    <dbReference type="InParanoid" id="A0A1Y2B7F0"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY30768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="530" mass="58116" checksum="8FF3F232C2F6BB2E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7F6</accession>
    <name>A0A1Y2B7F6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_494318</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7F6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7F6"/>
    <dbReference type="InParanoid" id="A0A1Y2B7F6"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005365">
        <property type="term" value="F:myo-inositol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="71"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY30772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="560" mass="60471" checksum="9F7AE8EC379412E9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B828</accession>
    <name>A0A1Y2B828_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_527517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY30988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B828"/>
    <dbReference type="STRING" id="71784.A0A1Y2B828"/>
    <dbReference type="InParanoid" id="A0A1Y2B828"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="107"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="190"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="302"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY30988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="390" mass="40368" checksum="834794F72CBCDD1E" modified="2017-08-30" version="1">MSDTSPPPTATKRAASPLSPDNATASKRAREEPSSPAAEETPVKEESGVKSGNGTTETRETAEGEGKKKMDDVNMEGGTAGPSSATVSSLPESVPAAPVAAAEAPVAQIAMRSLIVTQDASIIIGRGGTHVNEIREKSSARVTVSESIPGNPERILNVSGALDAVAKAFGLIVRRINDEPFDVPSVPGSRAVTIKFIIPNSRMGSVIGKGGSKIKEIQEASGARLNASEAMLPGSTERVLSVSGVADAVHIAVYYIGTILLEYQERNPGAATGTYRQAGARGFPSAAAPAPTYVNNTANLPGAQTQQIFIPNSLVGAIIGKGGAKINEIRNQSQCQIRVTEPGTPVQPGGVANPEERLVTITGQPANINMAVQMLYARLEAEKQKAASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B849</accession>
    <name>A0A1Y2B849_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_466237</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B849"/>
    <dbReference type="STRING" id="71784.A0A1Y2B849"/>
    <dbReference type="InParanoid" id="A0A1Y2B849"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="731" mass="82833" checksum="E217A03BC540595D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8G9</accession>
    <name>A0A1Y2B8G9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_528026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8G9"/>
    <dbReference type="FunCoup" id="A0A1Y2B8G9">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8G9"/>
    <dbReference type="InParanoid" id="A0A1Y2B8G9"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="172" mass="18694" checksum="FA3EC8AE51419164" modified="2017-08-30" version="1">MRDFPSSPPAAVLSTKSPLFIQRSQSLVSTTSTLKTLPNKMTKKRRGGGRNKKGRGHVKPVRCSNCSRCVPKDKAIKRYSVKNMVEAAAVRDLSEASVYAEYALPKLYIRVAYCVSCAIHAKIVRVRSAKPGAINSRKNRLPPPRAVFKDGKRINPTVAAAMAAKTAAGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8Q5</accession>
    <name>A0A1Y2B8Q5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_527004</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8Q5"/>
    <dbReference type="FunCoup" id="A0A1Y2B8Q5">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8Q5"/>
    <dbReference type="InParanoid" id="A0A1Y2B8Q5"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001010">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="56"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="454"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="637"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="718"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY31231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="774" mass="82952" checksum="AB14999DE7B64E87" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8R4</accession>
    <name>A0A1Y2B8R4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CLF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor clf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_95367</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8R4"/>
    <dbReference type="FunCoup" id="A0A1Y2B8R4">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8R4"/>
    <dbReference type="InParanoid" id="A0A1Y2B8R4"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000327">
        <property type="entry name" value="Pre-mRNA-splicing factor CLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000639">
        <property type="entry name" value="Pre-mRNA-splicing factor CLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="62"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="682"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="701"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY31238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="729" mass="85917" checksum="87B99A4191AC50FE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B905</accession>
    <name>A0A1Y2B905_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_558350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY30990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B905"/>
    <dbReference type="STRING" id="71784.A0A1Y2B905"/>
    <dbReference type="InParanoid" id="A0A1Y2B905"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="72"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY30990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="223" mass="23964" checksum="0365421B44E86384" modified="2017-08-30" version="1">MLSHATRQALRVASRQSLRALSSVPARTATSRASATLALGTAVAAYGLYESSKAPAKAEGAKTIAGEKGTVSERSFVMIKPDGVSRQLVGKIVSRFEERGYKLVAIKSLTPSPALAKEHYIDLASRPFYGGLVKYITSGTPVVAMVWEGKDIIRQGRRIVGATNPLESDPGSVRGQYAVSVGRNLIHASDSFESATKEIDLWFSEAELSSYEPTAWGWVMADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B930</accession>
    <name>A0A1Y2B930_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_527515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY30987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B930"/>
    <dbReference type="STRING" id="71784.A0A1Y2B930"/>
    <dbReference type="InParanoid" id="A0A1Y2B930"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11332">
        <property type="entry name" value="AmyAc_OligoGlu_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="25"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="565" mass="63274" checksum="E781A30F553AD784" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B966</accession>
    <name>A0A1Y2B966_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidiation protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_587469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B966"/>
    <dbReference type="FunCoup" id="A0A1Y2B966">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2B966"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="91" mass="9934" checksum="4FCE192676A9AF32" modified="2017-08-30" version="1">MSAKQVAGGHKAAINNDSVPQESKEHSKKVFNEMDESDEGSEEVPQVDKDDNSKNENNVIGGHKATLSNPRVGEEAKEHSRQVLQEHGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B974</accession>
    <name>A0A1Y2B974_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_466122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B974"/>
    <dbReference type="InParanoid" id="A0A1Y2B974"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="526" mass="58642" checksum="F977FE89C7EB2C6D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA84</accession>
    <name>A0A1Y2BA84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ceramidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_526675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA84"/>
    <dbReference type="STRING" id="71784.A0A1Y2BA84"/>
    <dbReference type="InParanoid" id="A0A1Y2BA84"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="315" mass="35242" checksum="AA4315A4420CF440" modified="2017-08-30" version="1">MGAFDGLRGGQISHGYWGPHTGTIDWCESNYSHTPYIAETYNTVTNIPVILAGIYGALATYFAGINKRYAVCYLGLSFIGIGSTGFHASLRWEWQLLDELPMIYVVSYAALMVLDTLPGFKPRYGIWGYLVLTAWCLFVTFSYLYLPNPVYHQVAFAAILLGTTARNVTLIRRLPSAHPGRKLVTRYMAWGIFTFAAGFGIWNLDNIFCTYLRSWRELLGIWGFLLEGHAYWHLMTGFGSFWIFTAAIYLQLAIKVSPEAYTFDGNAWLPTVRPTVPAKSAVVVVDKKGEVVGTGETLVDVKEKSKEQDGKQNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB99</accession>
    <name>A0A1Y2BB99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB99"/>
    <dbReference type="FunCoup" id="A0A1Y2BB99">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB99"/>
    <dbReference type="InParanoid" id="A0A1Y2BB99"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="780" mass="83498" checksum="D8CA2200DCE3FF5B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBG6</accession>
    <name>A0A1Y2BBG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_524445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBG6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBG6"/>
    <dbReference type="InParanoid" id="A0A1Y2BBG6"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="110"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="450"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="565" mass="63391" checksum="15AE754EA877DF81" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBS4</accession>
    <name>A0A1Y2BBS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_523756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBS4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBS4"/>
    <dbReference type="InParanoid" id="A0A1Y2BBS4"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="253"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1093" mass="117675" checksum="8D408BCDDBBDA641" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCN7</accession>
    <name>A0A1Y2BCN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_523045</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCN7"/>
    <dbReference type="FunCoup" id="A0A1Y2BCN7">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCN7"/>
    <dbReference type="InParanoid" id="A0A1Y2BCN7"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000017">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY32593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="459" mass="50021" checksum="08EF36E390F1DAAD" modified="2017-08-30" version="1">MTLPTPTSTPPVLETDILSSPGPFEGPEKLLEVWFAPSASALPETSAAGAARYRPAAVQREWKGLRRVPRAVWEEMLDIVKCKVLSVVEGAEVDAYLLSESSLFVAPHLLILKTCGTTLNLLGLHRIIEIARAYCGFTTVWRCFYSRKSFFFPERQSGPHRDWRDEVTFLDSVFGAAGSAYTVGPMNRDHWLLYLTSPNAQPLLPSDASLSSDFSLSLSLPSPPALDRPSTYQDSTIEILMSHLSPEGRAPFFAPSPAPGPEASGTLSGHELGAQISHRLGIDTLFSRGETTLDSFGFEPCGYSANAVVGSGSPETNIPGGGYFTIHVTPEDGWSYASFESNIPLPQTSTADRPDIATLIRKVVGIFQPSRLSITLFVSTPPEGGIGESEAERRAWSALGTDLLGREFARKDRIGYEFDGYDLVFACFEKRGWVEPKSRISAKDAVKGLQNGQGQVQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCT8</accession>
    <name>A0A1Y2BCT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BAR domain-containing family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_523803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCT8"/>
    <dbReference type="FunCoup" id="A0A1Y2BCT8">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCT8"/>
    <dbReference type="InParanoid" id="A0A1Y2BCT8"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="305" mass="32544" checksum="08F394487BBE56ED" modified="2017-08-30" version="1">MQSSWKNFTASLPAVDVSGVSKNLRNTVQLTRERLGNVGPDGITELPAEYKQLEARVDALKDVHTKLLKITKVHETESYDYPSDIAESVSDISTQAASVWSTFANKNLKNTNLPIPIPSPSVKTAHAPKTLPHALSRAAKSGAVELGSADRLGLALGVYGAAMEKVGDARLSQDALIADRFVTPWQATLSTSIGLAMKARANVKTARLELDSARAALKSAAAAKQEQARLHVEEAEDKLVQSTETAIGLMKAVLENPEPLQNLSSLVKAQLIFFSTAAETLSGIQGEIEEAATAAETEYRASRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDC1</accession>
    <name>A0A1Y2BDC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_464113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDC1"/>
    <dbReference type="FunCoup" id="A0A1Y2BDC1">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDC1"/>
    <dbReference type="InParanoid" id="A0A1Y2BDC1"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000006">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="376" mass="41738" checksum="EF5E6764A6ED8242" modified="2017-08-30" version="1">MLDSRSTLLNGNHSFPPFYACYLLRSRATVTSRITYIGSTPDPPRRIRQHNGQLTQGALKTSRFRPWEMQMIVYGFPSKLAALQFEYAWQRPEKTRHLREDTTDGQYGLLIKKDRERNMLNRKVAVVCALLALPPFSRLPLHVRFFNEDVQTLFESRRRDQAQGLPLSLSTILDLGGVAGDTGRRVATTPGVTAIDGPIDVEDYHFRDQVWQKLITLTSTPACLICGTQVDMQDHLSYSLCPVGGSCLATTHVDCLGADFVRGQPTLLPSHGQCPGCHEEVQWGEVIRSTYACKELHAAPTLRGTRKRQGQKGAVINSLSSAADLNSQPDPAPEEVNQDSSKPPMPKPKARRKPSRRKPSQAIDHKPGSSSSTGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE04</accession>
    <name>A0A1Y2BE04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_521016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE04"/>
    <dbReference type="FunCoup" id="A0A1Y2BE04">
        <property type="interactions" value="735"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE04"/>
    <dbReference type="InParanoid" id="A0A1Y2BE04"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="707" mass="76994" checksum="8846723CEBC7952C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE38</accession>
    <name>A0A1Y2BE38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_521235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE38"/>
    <dbReference type="FunCoup" id="A0A1Y2BE38">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE38"/>
    <dbReference type="InParanoid" id="A0A1Y2BE38"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="273" mass="30039" checksum="FCB680D3113B62EF" modified="2017-08-30" version="1">MGVIDKIKHALHHEKPAASTGASGSELQMPEFDKFDESKVTVIFVLGGPGAGKGTQCERLVADYGFKHLSAGDLLRAEQDRPGSEYGDLIKDYIREGKIVPMEVTIKLLEVAMHEAIKTPPNDSEAWKDGKGLFLIDGFPRKMDQALKFDEAVCQSSFVLFFNTTEQVMLERLLERGKTSGRADDNRESITKRFRTFVDTSMPVVKYYGGLGKVVEVDSSPDKEIVYANVKKAVDERLGRTATVTETETETEAPIAQPTTTGEPPNLAPVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BED4</accession>
    <name>A0A1Y2BED4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_521937</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BED4"/>
    <dbReference type="FunCoup" id="A0A1Y2BED4">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BED4"/>
    <dbReference type="InParanoid" id="A0A1Y2BED4"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="203"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="460"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY32837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="515" mass="57102" checksum="57AAE99ADC93D469" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEX2</accession>
    <name>A0A1Y2BEX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_523294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEX2"/>
    <dbReference type="InParanoid" id="A0A1Y2BEX2"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="408" mass="44399" checksum="E55CFE136F09CF7E" modified="2017-08-30" version="1">MPEEPKDLILLVWVHGFKGNEVTFESFPDRLSHLLRQTHVSLRVESRVFPAYETRGELHAATLAFVDWLTGLVVELENDHGSGGGAGKAKIVLLGHSMGGLLLADAALDIARNTRDGDPMWPHVVSILAFDTPYLGLHPHTFKHGLSTAASYYEQAKSVASAVGLLSPMALGLGFGKFGSSSSSSTSASTTPSGRTSPSTKGKEKAVYTSDTDTTSAHSQKKSWWSAIPPPSNRTMYGLGAVALGAAAAGTAYYRREDLANGWKFGYEHMTFVRNLWDEAALRGRLDGIAELGDHHRVLFRNFYTHLPAKPPSYLISRTFCILPPMSHPLYPVFVAASNTVAADEVSAHMGMFNPKTNDGFYDLGLEVIKVLGARIEEEGVGRVAREEGIDGWREEKGEDGKVIWVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF28</accession>
    <name>A0A1Y2BF28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_586707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF28"/>
    <dbReference type="InParanoid" id="A0A1Y2BF28"/>
    <dbReference type="OrthoDB" id="2151417at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38849">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38849:SF1">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012327481" evidence="2">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="338" mass="34547" checksum="DD88C09ECC048B5C" modified="2017-08-30" version="1">MYTHSYLVSLVPLLALVASSPVKRQGSTCAPFALQDYAAFQISDGTAGDARTQANAVFVDPFAGCDLSTVDATSLSNIQTMREAAETAETARFDPAIDAASGDTATALQNGKIKNKVLKLTGEIQALSIQLAQGKNTQSDIDAEQTKLDSNVKLDTAAAGQSSQGITNSTSTKRSLAIQPRKHKDHEKAAAACTATAGSTPVNATTADSDFTSTNGNATSIEGDDSTVANLAIRSIQWLKRHHKANKNDATACTDTAVGDSSSNTTTIDDTGSANDTSSTTASASDVSANSTISNTGSINGTSTNDTTDSSIGGSNAEASVSSASDTSTNTARLRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG31</accession>
    <name>A0A1Y2BG31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_519178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG31"/>
    <dbReference type="FunCoup" id="A0A1Y2BG31">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BG31"/>
    <dbReference type="InParanoid" id="A0A1Y2BG31"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="192"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="393"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="564"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="770"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="103875" checksum="C11C7701886ED9B3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGV2</accession>
    <name>A0A1Y2BGV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">JAB1/Mov34/MPN/PAD-1 ubiquitin protease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_518232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGV2"/>
    <dbReference type="FunCoup" id="A0A1Y2BGV2">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGV2"/>
    <dbReference type="InParanoid" id="A0A1Y2BGV2"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="37"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="314" mass="34856" checksum="1632BD989A7D80EF" modified="2017-08-30" version="1">MDPNLMRLLQQVRGGGGFGQRQMPQGDTILADNGETVHISALALLKMLKHGRAGVPMEVMGLMLGEFVDDYTISCVDVFAMPQSGTTVTVESVDHVFQTKMLEMLKQTGRPEMVVGWYHSHPGFGCWLSSVDVNTQQSFEQLHPRAVAVVIDPIQSVRGKVVIDAFRSINPQSLIAGQESRQTTSNIGHLNKPSIQALIHGLNRHYYSLAIDYRKTEAEQGMLLNLHKRGWTEGLKMRDFQELKEGNEAAVKQMLSLAVAYNKSVQEESTLTPEQLKTRHVGKLDPKRHLEEAAEKAMGDQVTQNLAMGVLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGX6</accession>
    <name>A0A1Y2BGX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_518041</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGX6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGX6"/>
    <dbReference type="InParanoid" id="A0A1Y2BGX6"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="528"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="771"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="328"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="864" mass="96280" checksum="75DF6528E7654153" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH62</accession>
    <name>A0A1Y2BH62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_503741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH62"/>
    <dbReference type="InParanoid" id="A0A1Y2BH62"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="53"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="297" mass="33438" checksum="5F598DF1BBA9CCF3" modified="2017-08-30" version="1">MELITDDVDMDDAEWSYQTHWATTSLEHVIPGQRSALVDANSSVLQDVHYLAVDTNILISHFPLFKSMYTHLAVSNKTAYNHLAPIDKTAYTRLAQPDDESTPLVLLIPYTVINELDGLGSRGSDDETLGIAARTATAFLLDVQRNQTSTKRKILHCQRWSERNDSSDRTGIESGEKEAGDEGDMEIELDLQAMQDYRHGKASFEIPHDSRTTTTTTNTNTNGAIRPDIHDDMLIDQDITTTTTTTTRHDSIIDLLADIPLPSRIPKANQRRPPQSLIDDFIVRFVTFEYPTSERYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHL4</accession>
    <name>A0A1Y2BHL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_517370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHL4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHL4"/>
    <dbReference type="InParanoid" id="A0A1Y2BHL4"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="295" mass="32129" checksum="2CE8BC68A96FCBC6" modified="2017-08-30" version="1">MVELKKESSNRVSTGTLTKYSFASGSLGGLTTQLNVFLPSTASSSSPAPILFYLAGLTCNEDTGAQKGGFLNTAGKEGIAMIFPDTSPRGAGVEGEDDDWQLGTGAGFYLNATADKWKKHYNMYDLIIKEIPAVLKEAGLALDWSKVSIMGHSMGGHGALSLYLKNTGIFKSASAFAPACNPSRTPWGTNAFTHYLEARTRSSPPSEWLEYDSTHLLAASTAPKGSLHLLVDVGTEDKFYKEKQLEPESLKQAAKERGSDEELEVRMQDGFDHSYYFISTFAPEHVEYHAKYLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHM3</accession>
    <name>A0A1Y2BHM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_462679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHM3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHM3"/>
    <dbReference type="InParanoid" id="A0A1Y2BHM3"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="398" mass="45820" checksum="044024B69BFF8521" modified="2017-08-30" version="1">MTDLRPLLPLSLQDPSSPRRSYLSLVVSQVRRRPYRLVILLCLFLFILLNLHTLGTFRRDLIYLIRPIWDTPERAFTIIDHFPLPPGPDLPKPQLISKWCQLHGWDTRPDGPPRIVDAILFSTELDMLEIRMREYAKHVSTFIVVEANATFAGDPKPLHFAEHRERFNEIAAEAGGKVVYRSVLDLKKGQPRGSFVNEETMRRVVGDVLSELQLPKGSLVIQTDVDEIISRDTLNLLSSCHGFPPELHLNVKNYRYGFNFPIPDQGYWRPRIHTITAQETNVPYYHGRGGDTLLADAGWHCTFCFRTLVEMVAKMRGYSHNDRLRSEDLVDLKNLRHRVCVGKDPFNMFPEAWTFKDIIAQSGSIRHEHSFRNLPIALAQDPLRFSYLLSGGCERPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI35</accession>
    <name>A0A1Y2BI35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_516819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI35"/>
    <dbReference type="InParanoid" id="A0A1Y2BI35"/>
    <dbReference type="OrthoDB" id="2146436at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF11">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012576002" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="223" mass="23082" checksum="B20DB8D442E91590" modified="2017-08-30" version="1">MFSFRGLLGASVLVSTAMAHYTLDYPISRGFDDDNEVNFCGGFNSVENPRQPFPLSNGTIHIDSHHTLATVVAYISTSSNPTSFNDFNTTSNGTSIPLLTNFFQVPEGDSCWTVDMAGLNIGLTNGSLVTLQVQFDGGDGNLYQCADLVLLSDFTTPSNETCSSDATTASITSTATSSQAASSTSNTATSAAATQSSGAAVLGVKAGSWLFGMVVGLAGVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI94</accession>
    <name>A0A1Y2BI94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_517492</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI94"/>
    <dbReference type="FunCoup" id="A0A1Y2BI94">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BI94"/>
    <dbReference type="InParanoid" id="A0A1Y2BI94"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="15">
        <location>
            <begin position="218"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="602"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="439"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY34290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="677" mass="76439" checksum="9C15718DAF0E7CA6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIM4</accession>
    <name>A0A1Y2BIM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_513666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIM4"/>
    <dbReference type="FunCoup" id="A0A1Y2BIM4">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIM4"/>
    <dbReference type="InParanoid" id="A0A1Y2BIM4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="281" mass="31869" checksum="50B748325BD8334E" modified="2017-08-30" version="1">MPTVTSLAARLKMRDGHSIPQFGLGVYEMSDSETYNSVKWALEAGYRHVDTAEWYENEGACGRSLSDWLKSSGTPRSEIFFTSKLMHNRTYASALSDLRLSLKKSGLTYFDLYLMHSAIGGPEIRKEVWRALCDAKEEGLVRSIGVSNWGAKHIQELLDRNAELPVINQIDLHPFMRHPEIVDICEKNDIILEAWGPLARAMRFGHSVVVKAAKAHKKDEAQIMLRWGLQHGFVVIPKSVSQKRIVSNANIFDFELTKEEMAELDDLDEYLVTDWDVVDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIZ8</accession>
    <name>A0A1Y2BIZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_514559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIZ8"/>
    <dbReference type="FunCoup" id="A0A1Y2BIZ8">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIZ8"/>
    <dbReference type="InParanoid" id="A0A1Y2BIZ8"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="239" mass="26142" checksum="212BBF19E3D1F825" modified="2017-08-30" version="1">MIVPQNMLVARRAFHTTARAASHVGSAPITIPPSVKIEYPPLSISPDLPMASPMAQRFLRVTGPLGSQVLSLRPSVILNPPASEVPTLSVTVHNPTQKWQNSSWGKTRTLIDNAIKGVSEGYTVELRLVGVGYRASVEPIPEKFRLLQTQMPRKATRRGPGSPPYVEPPPPVDRINLKVGYSHPVLIDIPTDLSVTCSAPTKILLKGIDKQKLGLFAASIRKWRKPEPYRGKVCHACSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ71</accession>
    <name>A0A1Y2BJ71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_514954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ71"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ71"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ71"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="352" mass="39155" checksum="5426A32828C768E4" modified="2017-08-30" version="1">MYSLRVCQQPERARLCSYKEENETIDRRPVDPPPVVEVLSSDEHPPDSTTLFVRVLLIGTDNENVKVVKTPQGSDATAGEVVQTPEKLRLLDGSWGALCVFAKLSIRLPGVFQLKFILYETSLSGVEQISSTTSEPFEVYSPKLFKGMKESTPLTRHLAAQGLKVKLRTDTTVGRQSDSRRRTHASPETRQASPDSRLVWTEGEPVAPKRRRVGDDGMIPSIMTSWMDSTPRFDLSAFSLDSQKRDPSRLYSPQNSHPHPHIHTHTTTSTSTFQQSTPPPPPPPASTASPSKHRSRPSTNRLSIGPGDDGLPVLPFFAPPRLTTLIHPPEPEPEHEPDDDSDLLPPIRWPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJE6</accession>
    <name>A0A1Y2BJE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_135621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJE6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJE6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJE6"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="213" mass="23792" checksum="59DA73AC324FC31D" modified="2017-08-30" version="1">MSTPLLQQFPSLASYPPSFLKDLLSSPSLTEAFLFTLPQVQELAADIEKLGQENEELARRNMEIRDELLALREATAQSYGHAEALKAQWAEIDKAQASLYQRHRPSFLHLRLRHSLTAQDEASEKIATAFIEGRSSNFNGSGNGNESGSGSRVDSPAPGGYITPVGNSGSIDRGQNRAIDEFIQEFKAARKTYHKRAIWTERWSRGEVAWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJK4</accession>
    <name>A0A1Y2BJK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_194826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJK4"/>
    <dbReference type="FunCoup" id="A0A1Y2BJK4">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BJK4"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="105"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="551" mass="61979" checksum="A117A81299A8DDB2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJR1</accession>
    <name>A0A1Y2BJR1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_516074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJR1"/>
    <dbReference type="FunCoup" id="A0A1Y2BJR1">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJR1"/>
    <dbReference type="InParanoid" id="A0A1Y2BJR1"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="207"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="543" mass="59116" checksum="B9BF47527D21D02B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKM3</accession>
    <name>A0A1Y2BKM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_508754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKM3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKM3"/>
    <dbReference type="InParanoid" id="A0A1Y2BKM3"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="488" mass="52728" checksum="2A39455B247049BF" modified="2017-08-30" version="1">MRLEDTGVIGGAEGPRLPGEAQVNPTDTGLPLAEGMSLSYWLQGVRNRPLLNARTTEELPKEADVVVIGSGITGSLAALKLLESENPPKSVVVLEAREFCSGATGRNAGHCRPDQYRGFAKYSILHGPEQALKIMDNERETWEKVVQYVKDENVDCDLWVGKSYEVSMTPDVAEQATKIYADVVAAGGKTDNITVVTDPAEAEKISRLKGAQAVYYWDASTLYPWKLAAHVAGKALDLGLNIQTWTPVTAVTEAPSSPGQWNVETARGIITTPTVLYATNAYTGALLPETRGAIRPVPHMCNKVVPPTSFSGSKALQNSYGVIYPNGFFSVNPRPTSDGIVLVGGWNYNYPALVEHVAQDSSRRYNDGLTNFEPVTDAVKELTQDKFGWADQTGPGTKANYDYAWSGIIGRSSDEVPFIGAVPGKEGQWICAGHNGHGMARIFTAAPGIVKLMQGATWAETGLPECFEVSEERLARLAKADIKIDIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKN3</accession>
    <name>A0A1Y2BKN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_508759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKN3"/>
    <dbReference type="InParanoid" id="A0A1Y2BKN3"/>
    <dbReference type="OrthoDB" id="3361393at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="202" mass="22077" checksum="FBA529596745D4C2" modified="2017-08-30" version="1">MSFQDTADMVDEVGHRPSPVDTVVRPARHSTSPSRPNRFRQPFASSLLRFLPILAAYLISGALVTDRTSPPTFYTIALILTAAAFFPTAPVAAACSGLALFAQLFLALDHIHGHCGDNYAVLIGGEAPFKKGLGSLAWYRQCVQPAHAWWVMVLINVLWLFAFASEVFHSLRPSRSRIALPMNENLVEIPASLTTTSSRISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKX5</accession>
    <name>A0A1Y2BKX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Triose-phosphate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_509408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKX5"/>
    <dbReference type="InParanoid" id="A0A1Y2BKX5"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="55"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="343" mass="37345" checksum="971B00665BEE4A9B" modified="2017-08-30" version="1">MSHTKDEEASIPLNAMPRASDVENDLTHGERLEVKISEGRAAAPAKKIVIPAFIIIPLWMSVSICVILYNKYIFSSLHFPFPVFLTTWHLFFSACATRVLQRTTTLVDGARDIEMSRDRWIRSILPIGALFSGSLILSNYAYLSLSVSFIQMLKAFNPVAILLISFAFKIQEPNARLIAIVAMISTGCALAAYGELHFELFGFICQCAAVAFEASRLVMIQILLHGLKMDPIVSLHYYAPVCAIINACILPFTEGLEPFYALHRVGLLVLFSNAAIAFALNVAAVFLISVGSGLILTLAGVMKDILLISGSVLAFGSQITALQVFGYSISLGGLIMFKTTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL26</accession>
    <name>A0A1Y2BL26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative mitochondrial inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_514817</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL26"/>
    <dbReference type="FunCoup" id="A0A1Y2BL26">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL26"/>
    <dbReference type="InParanoid" id="A0A1Y2BL26"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="63"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="275"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY34795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="493" mass="53944" checksum="4FEE1F0A1E5B0A2D" modified="2017-08-30" version="1">MFRQRPAAPAERPPDAGPSSLDGGGIPSEGSSSTLPVQDTQSESFLSKIMADNPYFSAGAGLMGIGVALTALRRASTLGTTFAQRRLLVTLEIPSKDRSYPWFLEWMAAHAPQPGSGKGKGRMGFTSHELAVETSYKQHEGGSGEAIFNLVPGPGTHYFKYGGAWFQVKRERDAKLMDLHSGSPWETLTLTTLSRDRGLFPQLLAEARELAEQSTEGKTVVYTAWGVEWRPFGKPRRRREMGSVVLAKGAAERVEEDLKGFLGRAKWYAERGIPYRRGYLLHGPPGSGKTSFIQALAGAVGYNICLLNLAERGLTDDKLNHLLGLVPERSFVLLEDVDSAFSRRVQTTEDGYKSSVTFSGLLNALDGVASSEERIIFMTTNHVSRLDPALIRPGRVDVHELLGDAAPEQARRLFVKFYGRSGFNDVQSGEKEPEPETDDIQRMGDEVEQILEEEASQGRSVSMASLQGLFIRSGAEEAVESVRGLCTSRTSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLC6</accession>
    <name>A0A1Y2BLC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RFX DNA-binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_510869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLC6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLC6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLC6"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000422">
        <property type="entry name" value="DNA-binding protein RFX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="222"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="716" mass="80088" checksum="B6329AE6E8CC5A0B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLG1</accession>
    <name>A0A1Y2BLG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_510982</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLG1"/>
    <dbReference type="FunCoup" id="A0A1Y2BLG1">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLG1"/>
    <dbReference type="InParanoid" id="A0A1Y2BLG1"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01702">
        <property type="entry name" value="PolY_Pol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="38"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="537"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="578"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY35599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="616" mass="67954" checksum="353D2BD57B728EEE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLH8</accession>
    <name>A0A1Y2BLH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_596263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLH8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLH8"/>
    <dbReference type="InParanoid" id="A0A1Y2BLH8"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="54"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="401" mass="44337" checksum="C02B4A559BA3F42A" modified="2017-08-30" version="1">MTPRILPSHSSDYSPPDPNGRKTRGAMSAPPPLPTSELGIYRILSPKAGLRVSPLCLGAMSIGDQWAGFMGSALTGDKAFLFLDAFYEAGGNFIDCANNYQDEQTEMIIGEWMEARGIRDQIVLTTKYTTYPLMRKEGHFGGIGVNYAGNQTKSLKLSVDDSLKKLRTDYVDILYLHWWDYTCSIEEVMQSLNNLVKSGKVLHLGISDSPAWVVSQANQYAREHALTPFSVYQGLWNLGVRDLERDVIPMCRANGLAMTNWGALGRGLYKPPEELKERSSSIRGGIVPTEKDLKLAQAIKEVADEIGNGATMPGVAMAWCKQNMAYCFPVIGGTSIEHLKQNIKALEIKLTAEHIEKLSNAVPFDYGFPYTAYGRDPHYLPDGKPDSLLKMAGYHQFVTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLK4</accession>
    <name>A0A1Y2BLK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Formyl transferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_490700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLK4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLK4"/>
    <dbReference type="InParanoid" id="A0A1Y2BLK4"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047180">
        <property type="entry name" value="HoxX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388:SF1">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="87593" checksum="FC1970A9B53F28B4" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLN0</accession>
    <name>A0A1Y2BLN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_511403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLN0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLN0"/>
    <dbReference type="InParanoid" id="A0A1Y2BLN0"/>
    <dbReference type="OrthoDB" id="2592022at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="875" mass="96802" checksum="16B6F780DAFD0238" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMV4</accession>
    <name>A0A1Y2BMV4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_461071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMV4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMV4"/>
    <dbReference type="InParanoid" id="A0A1Y2BMV4"/>
    <dbReference type="OrthoDB" id="5427593at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="440" mass="47047" checksum="DB860E7A600A442E" modified="2017-08-30" version="1">MVQLQVIGLNCGTSVDGIDVAQVLITSAPDTSDVKIALLSYREHPIPPALRTRVLSLCRPGADTTLEEICDLNFELGELFAEAVLSSGIDLSQIDIIASHGQTLWHTPVVANQGAGYAAGERRMATLQMAEGAVLAQRTGLTVTNDFRVAELAQGRMGAPLAGFFEAALVRHPTKLRVSQNLGGMGNVTVIPPSNSPLAPGYMAFDTGPGNVLIDAAIRLLTNGVLQYDQDGIIGKRGEKELDQSFIDKFIDSVDYLAREPPKTTGRELFSDDMARRLVVELQARGMSDEGIIANITRITAETVVRALEQFVVPHYGKMEEIFICGGGAENPNIVGYVRQMFPNATVAKLNEATSPSPSKDATVKSTGGGIPADAKEAVMFALLGFLTVCGRSVPVASGEMSKEESIMGKVTPGRNYVEVMRKALCSEDQRGTLGRILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BNA4</accession>
    <name>A0A1Y2BNA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_511283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BNA4"/>
    <dbReference type="FunCoup" id="A0A1Y2BNA4">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BNA4"/>
    <dbReference type="InParanoid" id="A0A1Y2BNA4"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="142"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="304" mass="34306" checksum="28F178A5CB12F194" modified="2017-08-30" version="1">MSFFDNEEEEDESPFNASVAAQPAEPIGGWSSAEGSSSRYNRNRASSLVSATESGIGSRSFLSRLESTVSPHGKGRSGGLFNQTQDEDEVGVGIDDEEDDEDELDDVSRMGKVWVRERGTVDVMRWEGDLIDTLFDKLEQQAKMVNTLHSDPQTSEEEHFKLVLVQTEMERVKFLVRSYVRTRLSKIEKYSHYIVLHPEIHQLLSGAELLHAKRYTELLHTHFQHSVLDSLPEWLRKMDDTYGDGLSMVTSPNKNVPVLIYCQKDCGEILLEGGESAALAKGTTHLVKYSLVERWVQLGWAEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADC1</accession>
    <name>A0A1Y2ADC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_555280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000133">
        <property type="protein sequence ID" value="ORY20506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADC1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADC1"/>
    <dbReference type="InParanoid" id="A0A1Y2ADC1"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY20506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="136" mass="15045" checksum="C09D4E285F9DC00C" modified="2017-08-30" version="1">MFRPNLPSIAKRGLRTFRQGGLKLAEAQEAALLNGTSPEPVKQVIVGGPFRIQRSATGGLPVYSVARNDGSWKTIVRKIEGDVVHFQKQLNAYLKETHIDPLKAPPQATLRPTNMNLSIKGKHTSDVKDFINLRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE36</accession>
    <name>A0A1Y2AE36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_554814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000125">
        <property type="protein sequence ID" value="ORY20791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE36"/>
    <dbReference type="STRING" id="71784.A0A1Y2AE36"/>
    <dbReference type="InParanoid" id="A0A1Y2AE36"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="4">
        <location>
            <begin position="125"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="388"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY20791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76106" checksum="A3D00F5DCFCD33CA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFF2</accession>
    <name>A0A1Y2AFF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_553813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000113">
        <property type="protein sequence ID" value="ORY21328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFF2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFF2"/>
    <dbReference type="InParanoid" id="A0A1Y2AFF2"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY21328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="380" mass="41769" checksum="E9F6EB74A9C9302C" modified="2017-08-30" version="1">MSLLSIGTKCSSCNLVDFLPIPCSRCNLPFCSTHISTHQCHSNSSSSTSTLRSSDLDGSKDVPFRSICGYEGCERISIEGIGGYDDMDMLGPAKQVRCSFCSRAFCTLHRQQAQHDCPGPKDYTVRSEAALVRKAKAEEIMARTFPEMIGRVIPKPPRGRDVVIKEPTSKTISIGVSKTTSIGGSKTIPIGLSKTGSTEVSKLGSTGESKTVSTEVQEAPSSSSSTIPVIDIESKEQVKKVKSKADKAWEIQLRKIRSTARPLESGKGTDEHERRRFFEIDVRLDGSEKAVKDWLEGRDWPWVGKAERVWVREDMPIGKVLDLIIQQKKVIRPKPTEPQLKLRALVATPDEPRSVRHLDTAHPASSIPEGSLVVLSRTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFW4</accession>
    <name>A0A1Y2AFW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S12/S23-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_553523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFW4"/>
    <dbReference type="FunCoup" id="A0A1Y2AFW4">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFW4"/>
    <dbReference type="InParanoid" id="A0A1Y2AFW4"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY21459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="172" mass="18407" checksum="B7267BADE6A8E387" modified="2017-08-30" version="1">MASSRSVMSLCSSLSRLSVAPRVLNPIASSSRLSPIRSFSSSSPAQATINQVLRGARTRKTLESRAPALEGHFQKKGVCAKVMTKKPKKPNSANRKVCRVKLSTGNMITAYIPGEGHNLQEHSVVLIRGGRLKDLPGVRYKVVRGAQDLSGVAGRVTARSKYGAKKPKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGY8</accession>
    <name>A0A1Y2AGY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_554096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000116">
        <property type="protein sequence ID" value="ORY21225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGY8"/>
    <dbReference type="InParanoid" id="A0A1Y2AGY8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="87" mass="9793" checksum="65AB6B8D24D58F4E" modified="2017-08-30" version="1">MHRSFWCSAYLRLTVQKKARKGAPCQRRAKTRAFCKRGFSLPLLTAANLALIDPSCKRGHVDYADSDDILSVRLPVSKGWNSWPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHN3</accession>
    <name>A0A1Y2AHN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_552477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000100">
        <property type="protein sequence ID" value="ORY21982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHN3"/>
    <dbReference type="FunCoup" id="A0A1Y2AHN3">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AHN3"/>
    <dbReference type="InParanoid" id="A0A1Y2AHN3"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="292" mass="31340" checksum="77CF0167A7E792F6" modified="2017-08-30" version="1">MSRSYDRALTVFSPDGHLFQVDYASEAVRRGTCAVGVRGSSCVVLGVEKKSALQLQESRTVRKVAMLDDHVCIAFAGLTADGRILIDKARVECQSHRLTVEDPVSIEYITKHVAGIQQRYTQSGGVRPFGISTLIVGFDPNDTKPRLYQTEPSGIFSAWKACAIGRSSKTVREFLEKNYTDGLSREDTIKLTVKSLLEVVQTGAKNIEISVMESYGVITNLEQTEIETIVATIESEKEAEAERKRQRVAQTQAGQASMAMGGAVSGTDTPQGGAAGEGTGDAGNTGAETGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AII8</accession>
    <name>A0A1Y2AII8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_552508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000100">
        <property type="protein sequence ID" value="ORY21987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AII8"/>
    <dbReference type="FunCoup" id="A0A1Y2AII8">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AII8"/>
    <dbReference type="InParanoid" id="A0A1Y2AII8"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="685"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY21987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="848" mass="95966" checksum="13198AD056084025" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIT2</accession>
    <name>A0A1Y2AIT2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_382716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIT2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AIT2"/>
    <dbReference type="InParanoid" id="A0A1Y2AIT2"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="482" mass="52714" checksum="5945FB4D4F8778D1" modified="2017-08-30" version="1">MRVRCLSLSLIRLPSRWGVHQPRRSTHDSRPNPANPSRASRLSHTNPSPTNLDRLNDRSNPNTASLLALLRRNPELSHLEATNELRWIQQSSKSDTDTERSCARRGDGEPLQYILGDVDFGPLTLLTRAPVLIPRPETAFVITRLAGLINSSLINSTSSSSTSLSTSPTSTSPSPSSSTSTSPSTSSSTSTPPSTSSTSSTSISTTTRTTTSTSSPGKISHRLKIADLCSGSGCIALLLSHLIRPRPIVRGYDISQSAISLSRENAQRLSSSYSSSTANLTSHSKSDSNFNSKFNSTSNSNSNPTSHSNSKAESNFNSNFKTISNSKVNSDSDFDSAPDITFTQLDLFHPQAIEVVKRGYGYDLIVSNPPYITWKEYHALPHSVKAYEDPRALLGDLGVTSSSHSRGLAFYQRIAAMLPDLLNTDSNDTYTRRLEYPRVALEIGEEQAQDVQSILLASRCVQRTEVWQDQYGKDRMVVGWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIU1</accession>
    <name>A0A1Y2AIU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_473965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIU1"/>
    <dbReference type="FunCoup" id="A0A1Y2AIU1">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AIU1"/>
    <dbReference type="InParanoid" id="A0A1Y2AIU1"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="2">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="503"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="3">
        <location>
            <begin position="745"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY22446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="950" mass="107067" checksum="059FAF45F6171E51" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIU7</accession>
    <name>A0A1Y2AIU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_551487</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIU7"/>
    <dbReference type="FunCoup" id="A0A1Y2AIU7">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AIU7"/>
    <dbReference type="InParanoid" id="A0A1Y2AIU7"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11600">
        <property type="entry name" value="HDAC_Clr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="268"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="13">
        <location>
            <begin position="626"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY22508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="902" mass="97149" checksum="E2A98CD842C60195" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ35</accession>
    <name>A0A1Y2AJ35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_508100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ35"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ35"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ35"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012417846" evidence="3">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY22504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="301" mass="31241" checksum="AC23E40C3BF3D0F9" modified="2017-08-30" version="1">MFSAVIVAALTAGSVIAAPIAERAQPSGWASGYLEDYETYHTRYLALSCETQHGTDFFESCCHPLLADESVSANRPSYCVANATQVSSAEAYEATAETVDGAASEFTNATSSIESVYESVVATATSSVADDSWTTDLASTTTIGAQALASDAAPTSTSTKEWVAPTTTSSTSTWVAPTTTSTTKAAATTTASSGSGQVESNAYATYFYQGGNAGACGNVHSDYDKIIAIDIAWYGNTGDVSQYCGKWITITNTNNGKSVTAQVADVCPTCDTNNSLDLSVGAFTAIATEDDGEVPITWQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJF7</accession>
    <name>A0A1Y2AJF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_551195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000090">
        <property type="protein sequence ID" value="ORY22624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJF7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJF7"/>
    <dbReference type="InParanoid" id="A0A1Y2AJF7"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43119">
        <property type="entry name" value="ABC TRANSPORT PROTEIN ATP-BINDING COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43119:SF1">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY22624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="249" mass="27046" checksum="039556B36C77D099" modified="2017-08-30" version="1">MSPLLSIKGLTLRRDDGTGSAILNDFSMDVEEGEVVIIKGESGSGKTTLLKCIAELNVYQSGEILLHDKKTTSYGIPTYRTLVQYIPQRPSLLPGTPLDLLETIRSFSSRKSSKSKSTSTSGIDGEDDSNDDLDPMRLASEWGIQRTLWTREWATLSGGEGQRIALALGIGIGGAEVVLLDEPTSALDAETMKKVENSLLSLLPPLKTQPSTSNGVRRRGIGPKAYVWITHEAAQAERCGTRTVDITRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKC5</accession>
    <name>A0A1Y2AKC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamin pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_473537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
        <property type="protein sequence ID" value="ORY22966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKC5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKC5"/>
    <dbReference type="InParanoid" id="A0A1Y2AKC5"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="7">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="279" mass="30974" checksum="BAA3687F293393A2" modified="2017-08-30" version="1" fragment="single">AMIILNQPITRKDVFVRAWRASEVHLCADGGANRLYDIWNADQRASYTPTMIKGDLDSIRSDVKAYYSASGVPVKYDGDQYATDLMKCIREVEAIEKATGRQLSLLLMGGLSGRIDQTVHTMSLLHKLRKSRPSSFVLSGESLAWVLDEGSHLIEIDHSTMGETCGILPVGIDKAMVHTEGLKWNLSELRYWTTSFDGQISTSNHLVPSEPVVSITTDRPILWCIEVRPNLGQSSPTNRVRTRSSYGPEELKRDIRGLSMGVARTAEDVGKDLLRVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKX3</accession>
    <name>A0A1Y2AKX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_549764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKX3"/>
    <dbReference type="FunCoup" id="A0A1Y2AKX3">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKX3"/>
    <dbReference type="InParanoid" id="A0A1Y2AKX3"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="155"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="350" mass="40441" checksum="EF160BACEB18874B" modified="2017-08-30" version="1">MSSVTYDFMSKYVPIVADHFAPMNATTARNTMYGGIALDNLNWLERLWASYYIWMGNPVLATGLMSFMVHEVIYFGRAIPWLIVDAIPYFRKWKLQPGKTVSNEQILKCAKIVLLTHFTCEFPLIYAFHPVCAYFGMATYEVPFSSPLLMAAQIAFFFVFEDTFHYWAHRGLHWGPFYKHIHKLHHEFSAPIGLAAEYAHPLEVLILAQGTISGPFLYCLFRKDLHIFTVYIWVTLRLFQAVDAHSGYDFPWSLRHWLPFWAGADHHDFHHQAFTNCYSTSFRWWDYMLGTDNKYHAFRNRVKNASAKDKAAVEKREIDRIEAEGIRAERLAAAGGGQGGMEGVKRGKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL92</accession>
    <name>A0A1Y2AL92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_361142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL92"/>
    <dbReference type="FunCoup" id="A0A1Y2AL92">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AL92"/>
    <dbReference type="InParanoid" id="A0A1Y2AL92"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000186">
        <property type="entry name" value="Translation initiation factor eIF-2B epsilon subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="6">
        <location>
            <begin position="345"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="675" mass="73957" checksum="A647E3A0EBB0223D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALG1</accession>
    <name>A0A1Y2ALG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_550188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALG1"/>
    <dbReference type="InParanoid" id="A0A1Y2ALG1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="236" mass="26229" checksum="979385B269EAAF92" modified="2017-08-30" version="1">MRDLSSPIASSSSSSMSSSFQRVNDTSTRLPSVTTSTSTLSRPSRSASSPTLVTISEVPCSSYEDDLLYDKSMEVNVDVQDDFGPFESEAELTEFLGWMESHEYRVAKRPRLPTIYEEPVVEKEMNEELANEREMYEQLSNDKEVYDEAPEMSMSDTDDEQSENSLPITPPLSRRPSSTIPLIYSSDADAPSSPTSTSGLGDFSKACELVNALDWTHRLIIPARVTGWLSKRPCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMS5</accession>
    <name>A0A1Y2AMS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tubby C-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMS5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMS5"/>
    <dbReference type="InParanoid" id="A0A1Y2AMS5"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="196" mass="22492" checksum="46CBE9E5035DC7A9" modified="2017-08-30" version="1">MPSKSDVKEWESFNPPLGLDQKRSTAGFTRLTLRKPLSWSSGDFVVEDEEGAVIFKCQGKFKSTQDRVIQDSEGQVVYTLSTRFWSMSRETIGLDSMGVEAFRIKKDNNLLHMKLHATFVDEAREEPITLSMQAKWYKDGADITWGELPVARMRREQYWKDKRELLIAPGVETALIFAMCTVFDMLEMETMGYAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMV3</accession>
    <name>A0A1Y2AMV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_548661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMV3"/>
    <dbReference type="InParanoid" id="A0A1Y2AMV3"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY23826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="60" mass="6809" checksum="9431437730F9E793" modified="2017-08-30" version="1" fragment="single">MRQLCPYLVSAIYETFRFTGSVFSGRMVLKKVQLRGINKVFSKGSIIRAMTRTASFDTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APH8</accession>
    <name>A0A1Y2APH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_600513</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APH8"/>
    <dbReference type="STRING" id="71784.A0A1Y2APH8"/>
    <dbReference type="InParanoid" id="A0A1Y2APH8"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012305148" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY24488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="471" mass="51262" checksum="2680B35009979342" modified="2017-08-30" version="1">MKAPALLAAALCFPVAWAAALDLGLVILQNQADSALGTLDSHLLHVDPDYNDTLRSSSLRKLCTLYARGSDKDDSDNLLAAVAQCGNGGIIRLPDSKYTIGKPMDITLHHSVLDIHGWLTWTPDIDYWVQNNIPLDFQNLGLAWVIRGHDFVLDGNNAGGIDGNGQVWYTWAAGVSNKPGRPMSMAIVGAKNVVVQNWSIIQPQFWASIVVDSENVLFHNYYVNATTNGSGTVQNTDGSNTYRSSNVTYENMVYQGGDDCIALKPNSSDIVMRNISCHGGMGIAFGSVGQYAGRTDFIENVLIEDVYVGPSTQWPVTTGFYFKSWVGHAIGVPPNGGGGGNGWTKNITVRNFEVDRVRYPIFIQTGLTYLEDERGKHQGSDLFSFSDIHVSNITGTCRGNRLAYLNCAKTSPCSNWTFADFDVQPGKTDHPELAFTCNNFVLGGDDGLNQCHPSNSLLELGPHGDIQYGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APL1</accession>
    <name>A0A1Y2APL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_546775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APL1"/>
    <dbReference type="STRING" id="71784.A0A1Y2APL1"/>
    <dbReference type="InParanoid" id="A0A1Y2APL1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="279" mass="30849" checksum="CA709CDD3D51F775" modified="2017-08-30" version="1">MAIEVVGNPESNNVELPKVRKFRRAAPPTFTDVHQERSYRKGRLAMACRIVAAQGWGIGCSMQLSSRDPVDTSSIYVIPAGRALAAIRSSDLIRVNIQTGVVLDNDSEWGYDSNAVAIHRAIYQGRPDVGAIIHGHTPHARSFSMHNRELEMIVQDSCTFYKRFHRMPFSVGKNAASEPEAVADCLQTGKGFVMENRGILLVGATIECSISYYIRMESLCQIQLLAEAAIKGRGGDFVRVGEQEVQFTFDNSGSEHHAWLMAMPYFARQDRLTGGATVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APT8</accession>
    <name>A0A1Y2APT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_547591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APT8"/>
    <dbReference type="FunCoup" id="A0A1Y2APT8">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2APT8"/>
    <dbReference type="InParanoid" id="A0A1Y2APT8"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="2"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="882" mass="94095" checksum="B66E957D6C4BCB7E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQK6</accession>
    <name>A0A1Y2AQK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_314427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQK6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQK6"/>
    <dbReference type="InParanoid" id="A0A1Y2AQK6"/>
    <dbReference type="OrthoDB" id="2576607at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="600" mass="67049" checksum="C9F17E0F392D40D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQZ0</accession>
    <name>A0A1Y2AQZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative low molecular weight phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_545336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQZ0"/>
    <dbReference type="FunCoup" id="A0A1Y2AQZ0">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQZ0"/>
    <dbReference type="InParanoid" id="A0A1Y2AQZ0"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="5">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="159" mass="17686" checksum="2B93D89F6D9D3FEE" modified="2017-08-30" version="1">MAEAVFKHQLSQRPTLTTHTDVLVDSCGTGAYHQGDDADERTVAVCRKHGVPISCTARALSKQDFSDFDYILAMDRSNLRTLQDRHRRSAPSSNPIISLFGSFDPSILQGKSTKAQEVEDPYYGGRNGFDECYKQCLRYSEGLLDVLEGKAELPQSQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR02</accession>
    <name>A0A1Y2AR02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_545996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR02"/>
    <dbReference type="InParanoid" id="A0A1Y2AR02"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013163961" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="54" mass="5609" checksum="A21DC369845C1709" modified="2017-08-30" version="1">MRYININTLVLSIALLASSATAALVTTTLPWADGNTLLLSVTTDAAGDVLTQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR73</accession>
    <name>A0A1Y2AR73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR73"/>
    <dbReference type="InParanoid" id="A0A1Y2AR73"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="128" mass="12801" checksum="49018E164014B44A" modified="2017-08-30" version="1">MASNTSSAPRKATNAGTASSAASESVARMFPKLAPSTCSTPSTAREPGKHESLELWNSDSKVTAAAPVNVATFYSLPTQGGSTTTPNPSTAADSIPQATTGAQKQSPARGSTTGKPSAGTLYGPTEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARA1</accession>
    <name>A0A1Y2ARA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_546790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARA1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARA1"/>
    <dbReference type="InParanoid" id="A0A1Y2ARA1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="719" mass="79889" checksum="2C7DAEA20591FD44" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASI6</accession>
    <name>A0A1Y2ASI6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_543897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASI6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASI6"/>
    <dbReference type="InParanoid" id="A0A1Y2ASI6"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="28"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="301" mass="33618" checksum="6BEF64ABE382DB7C" modified="2017-08-30" version="1">MSSGPIQYAQTPVLSIAYHEYGASTGWPVVLSHGFPYDPHAYDHVVPSLIRHGARVIVPYLRGYGPTRFLSPETMRNGQQAALGRDIIDLLDALGIEKALLAGFDWGGLASCCASALFPDRVVGLVSIAGYDINDVSAQLRANPPFLECRIWYQHLFQSERGRECLEQHRRDLCKILWKQWSPNWPFSEELYDSVADSFGNPDFVDVVIHCYRHCFGNAQGESAYEDLEERLRQRPKIVVPTITIDGIDDPLKPGGTAHHAEMFTGKHEHRAVKSGHALPFEAPEDFAAAILAVHDWVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AST6</accession>
    <name>A0A1Y2AST6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_282694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AST6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AST6"/>
    <dbReference type="InParanoid" id="A0A1Y2AST6"/>
    <dbReference type="OrthoDB" id="3341596at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="138" mass="14465" checksum="B9A718391F200D9A" modified="2017-08-30" version="1">MASSVTPVVVLADCPSMRGQFGQKCYNCGRFGHIARLCPGGPGGPGGFNAGPGGFRGRGGFAGGRPRPIPANADGTPVKCYRCNGENHLARDCLAPRDEATILASKKCYKCQELGHLASLRTFRDCPQVAAEELPTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT96</accession>
    <name>A0A1Y2AT96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_544850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT96"/>
    <dbReference type="FunCoup" id="A0A1Y2AT96">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AT96"/>
    <dbReference type="InParanoid" id="A0A1Y2AT96"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="15">
        <location>
            <begin position="33"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="14">
        <location>
            <begin position="463"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="731"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="468"/>
            <end position="470"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="468"/>
            <end position="470"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="763"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY25165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="792" mass="88972" checksum="E432D98D88B64C60" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATR5</accession>
    <name>A0A1Y2ATR5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_589987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATR5"/>
    <dbReference type="InParanoid" id="A0A1Y2ATR5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="32156" checksum="D28F1D880B313295" modified="2017-08-30" version="1">MPQLCEECQAMKDQVNEPHETPLDGPSLSKDEESETKTTVQPESKPTTSLTPHPTLISEIMIMPAPFLTTDPALATDPIQIAAEQEARIWGLARLQAVLDRLQAETPKQIPLPEDNEEEPVADSSVGEDKEKKKLKKQKQKEKKKEKAEKDKKDLEDYIERNRDRKGKQKEEQGQDMTQPDTNTSQQESEIEEMDTPRPVPLDLPLDADFEIPANYQGPFEPPPIDPNATPAIPTGSFHSDFMTPKGFTPSFLLGETPSPYPSEIGQSPYFPAGHSEEEEEDKDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU68</accession>
    <name>A0A1Y2AU68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_542251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU68"/>
    <dbReference type="STRING" id="71784.A0A1Y2AU68"/>
    <dbReference type="InParanoid" id="A0A1Y2AU68"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="584" mass="64369" checksum="4AA42F73D93D8286" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVH7</accession>
    <name>A0A1Y2AVH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_257564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVH7"/>
    <dbReference type="InParanoid" id="A0A1Y2AVH7"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="166"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38009" checksum="35382D70C6B93376" modified="2017-08-30" version="1">MSLPTSTKVITLVENPTGVVTEKTFSLQTTPLEPLKENQVLLKHSVLSNGPAIRSWIDSAYDKARWGDLHVYAGQPVVTEIIAEVIASTSEQWPVGKYVKGLFPWAQYSVQSAEGLQPAILIEGFSPWLSLSVFGFNGLTAYLAIFSELKLKKEDVVCVSSAAGSLGTLFVQLAAKVVGCTVIGIASGPKCEWVKSLGAKDCVDYKAPDFDARLSAALPGGCDVFFDNVGGAVLDAMIKHVKFYGRISVCGALSTYNHEPTVLQNWVEVVLARLNIKGEVTYQSALTTGYMVTDHFDKLPQAIEHLTQLVKDGTLQADAEEIVEAPIEDVAKLWISVFNNGPKGKFLTKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVT1</accession>
    <name>A0A1Y2AVT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_599686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVT1"/>
    <dbReference type="InParanoid" id="A0A1Y2AVT1"/>
    <dbReference type="OrthoDB" id="2349883at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="450" mass="49936" checksum="7CC15E0195062905" modified="2017-08-30" version="1">MSTSRRAINTYICSRGGLSAAVVPGARRARLSVIHTASRGSARAYSAESLRSPSNKISAVPFRITPEIATERLYSAGLVASSKLGNVLLAILQRIFGNWITAPAQEYGLGQGLTLNDVKAVYYPVWRCDAIFEGTVTNELKLDGGGEQAKGWVGLRGGYVPGNPFEPLSYLSFAVPPLEDELPVYDPVKDLKQLGNGYDVVPIPFTVTPFDLVKKIRQDMGVLTIWEALTVHEDRWTEKMLACYPVMFPIYIADFTFENSQDDSRRFQIVLDAHDSNIKNCRVSFPLPPEMIERMQPRNYYANPAPFIHQSQIEFVLPMIQPMLIPSRGMAAPNHFPPTGKDLSEVYNTYMSPPPQPELMPPSPLVEAHRNFAHPDGIDWTDQRIQSWSSDTRDENLTYVDAMLEYARGATTLQTLNNMPQGAEAHSKGIIIEVDKNDSGGNEIPFGVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWA5</accession>
    <name>A0A1Y2AWA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_540631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWA5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWA5"/>
    <dbReference type="OrthoDB" id="2564511at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24775" checksum="DA9AC21125BE3385" modified="2017-08-30" version="1">MSQDEPSSSHHRPTIARAPSFNSVENGGPSEPLTDHSPTTAKFPAGASLASAPAGSASNMGGLSFESVGRAIGSRVMRGVKRGNLPFLIVFLSALVIFFSALAGIGYVDPDDASLASPVDTLTPEAVEAAAVAAAEFQPGAPVFDPSEDQVELARRKKIEEQRELERQWQRKKRPKDGAWMQKQRDDKAVRRVPGKVAEETEATHEKRDMRFLEREANPDAAVQAEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWD9</accession>
    <name>A0A1Y2AWD9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_249026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWD9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWD9"/>
    <dbReference type="InParanoid" id="A0A1Y2AWD9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="468" mass="50611" checksum="C065F9ED7AC5BAD7" modified="2017-08-30" version="1">MNSPPSSPLSSPPPSPPFPLVPSSPLSPAPPSSQPLDISHRYPNDLAASLPVTLASLVDPCPVFNPSDPSTHAIIDSIMGTMIWSPTVESAWQTALNIFLWPLVQQFARASRNIRLNLDTGFDLNRVFVQDGTAFEDTEIQIALRAWEAESKQRPESETSSSFGVRRPDISTTLQLRLDDSATYCLVSMILEIKPDPPSKTMARQAVAQCILYLLTAYRSCGCWLGVGFHGGHYVRMIATDLRTIYIETSSSSTADELSVELLLYGGLDLYPWDLGTPSAPNIPHFGVLWRTVARSIEVLRNVRIDTPFVRLQSPLTQSDPNLFLDSRMEQLDLTADQDLMKVASVVRPSIKRALKARERDAPQRHSGGGSGEGGGSSGAAEQGQGEAEEEEGFDEQGGHGGAGGSNPRRGFRDGLRSGGAVESRGDVESSPSSARTSQASRSTNSNETPDTSVSSNSGMCFNLEFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWE2</accession>
    <name>A0A1Y2AWE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_497755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWE2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWE2"/>
    <dbReference type="InParanoid" id="A0A1Y2AWE2"/>
    <dbReference type="OrthoDB" id="5314275at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028018">
        <property type="entry name" value="DUF4646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15496">
        <property type="entry name" value="DUF4646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="326" mass="36545" checksum="C9849B80F6445925" modified="2017-08-30" version="1">MPFGLPFIARPGQEGFDAYGRMIPPDLPEGWDGWGRPIISGNPQPPIPPPAAAAMPLAANTVSPNTRDDMPSTVPPNSSTTESTGRPDQPSCFDRPPAQTDSYFRYDPFEAFSLPAAALNRAWELHLPRELVSHDVGEDDWKRFINDLSTEALQSARHDWISRRPTIPGRGPNPSLSDAVHALIASWAVAFFAPRGIKIYAASGGSRVIPRPVEPPLASKRGHDRADEWSDASSTLDDDDDEIRQEMEDRRADAHYPRVERIWRQNERERERRRARKRRGNERLLGGARPGADGDWEVCFVHSTPTLWTPGARPRTYGEPVVRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXN1</accession>
    <name>A0A1Y2AXN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_539597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXN1"/>
    <dbReference type="FunCoup" id="A0A1Y2AXN1">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXN1"/>
    <dbReference type="InParanoid" id="A0A1Y2AXN1"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="323" mass="35570" checksum="34159C45CA61928D" modified="2017-08-30" version="1">MDVSQELADYAAKHTTQVLERSQPVQVDMGLLAAFDNTPIDPSEYSSDLDAHLLQLTLTSTQALISALFALPTTPSAEHGPVIRPPVPSTILPREKPLPKPKEPTKWERFAQAKGISHKKRDKKEWDEERQEWVARWGRDGKNKQKEEEWATPVKAGMEADQDPAATARAERKARTAKNEKQHRSNLAQAAASSSASSRRTAQQARAADLERSMLVSKSATASMGKFDKSIEGEPKSRGVKRKFDENVPKAGWKGEKEGLLGVLKSVESGLGRKEKRKGETKEGEVVVRKAVRYHDREERLKAGRGGAGGGRGRGGARGRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXX2</accession>
    <name>A0A1Y2AXX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BCR39DRAFT_538046</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXX2"/>
    <dbReference type="FunCoup" id="A0A1Y2AXX2">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXX2"/>
    <dbReference type="InParanoid" id="A0A1Y2AXX2"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="275"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="427"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORY27443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="499" mass="54326" checksum="DB3793C91E92C470" modified="2017-08-30" version="1">MYIPFAASLASAILPFFSPTPATPTAEPRTLSFRPVHAHTHAFSDRSPPTLLFHNATSPQSFLFSNSIASDESPALTDVQDAVRPLSIRTRHMTIRRPRLRPPSMLSWAYAAQRKRNPYLPFSTNSSAEQWIAPDYNDADGDWEDVEVEAPDMTDRQTLITIAKMTSNAYVLPESAEWWPVGGWNATMPVGWEKDADGLRGHVFADPTNSTVIISLKGTSAGVLGAGGPTAKNDKYNDNLLFSCCCARVDFSWSTVCDCFAGGWKCGQTCLEDALVADSVYATVGTNLYNNVSYMYPNANIWLAGHSLGGSLAALIALSFGAPAIGIEAPGERLAAQRLHLPLPPGMPSEKTGITHIYHTADPIPMGVCTGTYSGCYAAGFALESKCHTGQTILYDTVTVKGWAVDVRTHRIGEIIDKVLADPWPGAEGQSVADNKAESSSWLPWGRKGPGKNKDKDKDGDDDDDDGWEKHGGVPRAQSEDDCVDCYRWEFGDWDKDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXZ1</accession>
    <name>A0A1Y2AXZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_506390</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXZ1"/>
    <dbReference type="FunCoup" id="A0A1Y2AXZ1">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXZ1"/>
    <dbReference type="InParanoid" id="A0A1Y2AXZ1"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="189"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="299"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY27087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="432" mass="47207" checksum="54ADF7DCD2458567" modified="2017-08-30" version="1">MSYKVADISLAAFGRKEIELAEREMPGLMYLREKYSASKPLAGARIAGCLHMTIQTAVLIETLTAIGAQVTWSSCNIFSTQDHAAAAIAATGVPVYAWKGETEEEYLWCIEQTLAAFPDGKPLNLILDDGGDLTALVHEKYPQYIADVKGVSEETTTGVHHLYKMFRDGKLKVPAINVNDSVTKSKFDNYYGCRESLVDGIKRATDIMLAGKVAVVAGFGDVGKGQQCAESLRSYGARVLVTEIDPINALQAAMAGYEVTTMEEAAPRSNVFVTTTGNRDIITAKHFEVMPEDAIVCNIGHFDVEIDVAWLKANAVKVVNIKPQVDRFTMASGRHLILLAEGRLVNLGCGTGHPSFVMSCSFSNQVMAQIALWTDAKSYPLGVHMLPKSLDEEVARAHLPQLNIKLTELSTVQADYLGLPIKGPYKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY18</accession>
    <name>A0A1Y2AY18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin synthesis regulation, resistance to congo red-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_538823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY18"/>
    <dbReference type="STRING" id="71784.A0A1Y2AY18"/>
    <dbReference type="InParanoid" id="A0A1Y2AY18"/>
    <dbReference type="OrthoDB" id="2574101at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010984742" description="Chitin synthesis regulation, resistance to congo red-domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21845" checksum="A51F353A48DFE15D" modified="2017-08-30" version="1">MLSTILLLALVPVALGQNICYDYYNRPYYCNSGISYGARIGIGIGVAAGVLLLFLLCGYWRRRNLRNQWAKYKPPALPYHNNETTTTNPYGSNPPPPPQSNFSSNQYGSNPPPPPQTYQPSMAGQYSSTGVNTYKTGATGVGAHEHGYEWEQAREQERLEREQGNANDIPPPGYDVAAQPARPAAHYAPPPGPPPISKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ02</accession>
    <name>A0A1Y2AZ02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_221565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ02"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ02"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ02"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010996012" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="209" mass="20619" checksum="A3FE89107CFD0FE4" modified="2017-08-30" version="1">MFSNLIALPLLITALTSCLAQTTHTITVGTNGTKTFTPTDIQAAIGDVVNFQFVTGNHTATQSTFAVPCTNNGGFKSGFKPASANDIATFAIMVNTTDPIWGYCGQVGHCQAGMVFAINAPETGNKTFAAFQSAAMSVSAGDGSNSSSSGSGTSAGANGSSSSLISSAGMSTGTGAASSTAASAGSASTLLPCSASMVGALLAGFTWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ22</accession>
    <name>A0A1Y2AZ22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_536871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ22"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ22"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ22"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="248" mass="27795" checksum="98387DC345AF2C82" modified="2017-08-30" version="1">MSTNKPDTSSEKYKESLSNSLRWDQVEGQAYIQLPSYPNLRLVPFRQGIEDEIVTLFSHEVIAKRLFRLPYPMYRHHAEEMISSLVPKHQALLAELSTHLPSPPPINTPLLPSSPTHIPGFPFKSLVDTTTGRKIGDLNLAARKAGMTDEEVLKLPSKEQDWVIGYVLDPGYHGKGIMSEMVGCLIDGWIKNWMDIRAVTALVEDNNTGSIKVVLKNGLVRVGSEDTAWPEEKGGGIRPTGQYERKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ66</accession>
    <name>A0A1Y2AZ66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_599288</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ66"/>
    <dbReference type="FunCoup" id="A0A1Y2AZ66">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ66"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ66"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="28"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="260"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY27764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="516" mass="56177" checksum="B7E3774B1C5B6ECC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZB1</accession>
    <name>A0A1Y2AZB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_468840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZB1"/>
    <dbReference type="InParanoid" id="A0A1Y2AZB1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="478" mass="52678" checksum="880995958C874F69" modified="2017-08-30" version="1">MKRDAFRAIANNGSDLPWYKNKGLRQLNAGLAAVCMCMALNGYDGTLNSGFQAEKSWKSVVGNPSASALGLLNASYYICGWVTMPIAAFVADRWGRKICVQYTAMTNLIGTAIGCAAGAGGTSGYGMYIASRIIMGSGFSFAICVCPIMLQECPHPRQRTVVAGLFDTVYNIGAFLSSWVVFGCAYLGNNWSWRIPYLIHIPFAVTMSILILFIPESPRWLMRNGREDEARAFLVKFHANGAADDPLVNFQMEEMRFALEQELKYKQGTWKYIFGSKGNRHRVGCAVLIAICQGLSGTGIIAYYYSSILKLVGITDTTTVTGIGAGLTTFTFCCACVGLYLTQHIKRRTHLAIAWSMTICANIALIVSTQQYQKHKSPRAGIASVVFVWIYNGSFWLACGSLFFTYPVEVLSYSMRAKGMMVWGLTNKSLAIFSQYTNPVAIAALGWKWYCFYTAVLVVTGIALYFMIVETKGLTLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZI5</accession>
    <name>A0A1Y2AZI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_537602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZI5"/>
    <dbReference type="FunCoup" id="A0A1Y2AZI5">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZI5"/>
    <dbReference type="InParanoid" id="A0A1Y2AZI5"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="9">
        <location>
            <begin position="111"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="10">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="308" mass="34940" checksum="3BCE98EE8FFF3960" modified="2017-08-30" version="1">MPFQSFKRSFTLSRTYTHLFPFPRNLLVIRMSSTNLTSLPPSSPSTKATDSVDPTPTSSSAPTKVKLTSHNQYSTPRLLRDQLHPDPLIQFNAWFTLALNGDESTHTPKVHEPEAMALSTVTLTSTSTSTQSKVSIPIPSTRIVLLKATDSQGFLFYTNYTSRKSQELLENPYASLCFYWRETSRQVRVVGRVEKVDRSDSEAYFNSRPVGSRLGAWASPQSTVVQDGEVQQRVEDVKKRFIPDTNLQQGGGQVQGEIEIECPEFWGGWRVIPFEVEFWSGQPSRLHDRFRYTRSDEASEWIIDRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B030</accession>
    <name>A0A1Y2B030_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPR1/FUN34/yaaH family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_496587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B030"/>
    <dbReference type="STRING" id="71784.A0A1Y2B030"/>
    <dbReference type="InParanoid" id="A0A1Y2B030"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="24027" checksum="E0E0F68A066E1AAE" modified="2017-08-30" version="1">MSDHNTEYLDANNAEKGQNRHLERVITPGGHPADFSQPAIPPQHRKYGNPVPLGLTSFGCGFFLASAYTLYARGVHTPNVMVPYTLWVVGNVPRKYIFVTFGVITAYTETDGTLSPQFNQAIGLYLMAWMMVTILFILGSLRSSGAVLATLSFTALAFLTLGIYQFNGSNSARIAGGRFLLLKMQTAWWGAMSGFWTRDTTFTWIKIDPIDMSPKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1C8</accession>
    <name>A0A1Y2B1C8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_536597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1C8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1C8"/>
    <dbReference type="InParanoid" id="A0A1Y2B1C8"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="4">
        <location>
            <begin position="122"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="44833" checksum="5DEAAF1F1219264F" modified="2017-08-30" version="1">MPIAIPGNTDTSSSSHTITKPSSSTPISTSTSTLLTSGQHEPDHSLIQPYSSFPKKITGRTVWKREDFIDDEKLWKRRWGKEHVQELESAYEAFESTGKSLEEITKETFPLPPGVSAFLHNIRDDVVNGPGFTLIQGLPVTDWDIKKTAAIYLAIGQQFGRTLSQNRKGHVLGHVKDLGNDPTQIDKVRIYSTAARQFFHTDSADIVGLLCLQRAKEGGESDVVSAHHVWNTLQAERPDIAELLATPNWYFDRKGETSDGQQGWIKKAVFYWHDGKLVSHYDPYYVKSITRFVEAGLIPGHSPAQLEAIQVLEETAQRLSLHMILAVGDIQFVADTHVFHARTAYIDYPAPAPRRHLLRLWLSTPTAEGGWKRPYPDSDHVKRGGIQVNQQPEKCPLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1V8</accession>
    <name>A0A1Y2B1V8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_533885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1V8"/>
    <dbReference type="InParanoid" id="A0A1Y2B1V8"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="731"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="779" mass="85457" checksum="89A38DBAD2D6F684" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2I1</accession>
    <name>A0A1Y2B2I1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_185192</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2I1"/>
    <dbReference type="FunCoup" id="A0A1Y2B2I1">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2I1"/>
    <dbReference type="InParanoid" id="A0A1Y2B2I1"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="11"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY29022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="370" mass="38780" checksum="7C3BA71ECAF523C0" modified="2017-08-30" version="1">MKRQLRSQAGYLATIQLGTPPADFLMLMDSGSGDTWVPSSDCGLAQCGPHQALGADVSSTFKATQTPFSVTYGSGSVTGALCSDTMSIAGMTLPNHVFGVTTEESQQFAAAQVPFDGLMGLSFSSLSQQNTSTPIESLAAAGLVIQAVMGFALGRVADGENDGEIIFGQPDTSKFDPAMTQVLPVSSESGFWQVAMADVTVNGQSTAQTRQAILDTGTSLMIAPSADAIAFHAQIQGAQASANGMFTIPCTSEAAITMTFGDTAFQIDARDLIFQPVSNDLQGDCISSLSSGTVVDDVTWLLGDTFLKNVYFTTNVEQRTVELSARTDVPGSSGNSTAVRANVEMSDANKARNSMYYVASALASLFLVWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2T7</accession>
    <name>A0A1Y2B2T7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_467739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2T7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2T7"/>
    <dbReference type="InParanoid" id="A0A1Y2B2T7"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="35"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="481" mass="52640" checksum="EFFAB9793130ECEB" modified="2017-08-30" version="1">MIDLGNGMEQVFVVDWLDHDPENPFNWSSAKKYANVIVAVLITTLTAANATSTAILAEWGPERFNCSREQYILSSTVFLITVAFTPLVLAPLSEVFGRMWIYQITGLINALLFIPQALSPSYSGLLAARWFQGMCASVGNSMVGGTVADLFFPKDRGLAMNVFSIMIFLGQSLGGFVFGWVGNGWGIQWCYGVQGIAAVVSCGLNALILRETRGDVLLARRAKALTKETGSKHICVADLQKQSFITLMRVSLIRPLEYLVTEPIVSAISTWIGFAWAIIFLGGTSVQLVFRAYGFSIGQAGTVQVCVFLGGVLGFISNFHQDRLYARAARKNGGRAPPEARLYWAAYGGLLFPLGMYVYAWTSRPGSIPWPVPAVFLTISYWGVFCMYSGTFTYLADAYETYSSSAQAAQSFARNFASGIFPLFGHQMYIAMGYPQATTLVASVALFLSIAPILLVRYGHVLRARSRVASALQREAEEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B389</accession>
    <name>A0A1Y2B389_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease P/MRP protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_455723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B389"/>
    <dbReference type="STRING" id="71784.A0A1Y2B389"/>
    <dbReference type="InParanoid" id="A0A1Y2B389"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="188" mass="20486" checksum="32BA8A2775388914" modified="2017-08-30" version="1" fragment="single">MVRFKNRFLLVEFLSPSDLVPSTSTSASSSTTPSSKPNTSEHLTTSYLDGNDEELIPLVPIVPFLLPRLNPIPQIRGKGDGGNGNGDSASIFRAIRGIIQDVFGDEGWGRVASSFKVVYHSTLTSITILRVARQHYRLVWAALTLVTRHSPSNSTVIPRVIAVSGTIKKVENHAIAYHRRVVAVLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B397</accession>
    <name>A0A1Y2B397_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_559106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B397"/>
    <dbReference type="InParanoid" id="A0A1Y2B397"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="189" mass="20242" checksum="991760258B640266" modified="2017-08-30" version="1">MAIKYRPGSGPGWTTGPPANEYGQSTALSPSSEPLTSQFDPPTSSSNRPTSHSPTRYTPTPADDTYSRAFNSFSGVLMLGGIISSSGPDKWEGLKKVSPWLISDFVSYVAYRFNSEDTPWSKPLCLSTCAAAATYSIGGPLWNIPCAFGLTFGMSIVRSGSETANSGSGWRSTLGLPERERPLSDDERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3K4</accession>
    <name>A0A1Y2B3K4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_532216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3K4"/>
    <dbReference type="InParanoid" id="A0A1Y2B3K4"/>
    <dbReference type="OrthoDB" id="2563669at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="454" mass="49090" checksum="B21BE83F40EFF594" modified="2017-08-30" version="1">MSRSNVTTNTSNLNVTIDDFDPLISYSDYSDWSTPDPQDHPDWFNASSSITSEVWHEATYHYTTVQGAQASFNFTGMFHVARSISQLLLFLSHLVSSCPSSSTFCSFLFLFNIKSHLYPSPYTSQSPLNLLSISSQSPLNLLSISSQSPLLSFPLYQYTNITKGSSVWIYGFTSSTPNYTLTIDPSSSQPYTTSLSNGNTTANERALLFSSEELAYTQHEVVLENQSGGLGVDLVVVGFEGGAEGATLANTTLDDRASEIVFTGSWTQQNNDLFYNTTSSYTEGPGNNFQVNFTGSAVYIYGDQVNDHGPFSVYINDTTTPYATHTGRSGCGGGYAKYCEKVHGLAFFANNLPEGQHTLRLENQGPSDGNMTYFDFDYLVYTTPSIYSTQSLASSSCPFTNCTTASTTSSTTSASTSTSSPSTSSSSAGELGMAVGNGALGLMMGAWFLRKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4B3</accession>
    <name>A0A1Y2B4B3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_173609</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4B3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4B3"/>
    <dbReference type="InParanoid" id="A0A1Y2B4B3"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000002">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000018">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013254377" description="Amine oxidase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="14">
        <location>
            <begin position="253"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="332"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY29317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="799" mass="90085" checksum="CD168C1EC73E891E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4C0</accession>
    <name>A0A1Y2B4C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_532347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4C0"/>
    <dbReference type="InParanoid" id="A0A1Y2B4C0"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="63211" checksum="489642CBC568EB9F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4L6</accession>
    <name>A0A1Y2B4L6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4L6"/>
    <dbReference type="InParanoid" id="A0A1Y2B4L6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="175" mass="19201" checksum="F289F29102CE6EBB" modified="2017-08-30" version="1">MPTSHPTDQSITSTFEESKLPEYNAARHSVETCLKDPKTTVGVISLEYSRQFVEGGRQKWLSVCCRTSDPTAGVPYDTAWTEMPDDSEGLTLVRCSWGSRDETPVIREDRFVNGAYVHDEEDFEFPGVPRSQTEQSAGMSADAQSTASGSTTSFCTLTPTKATSYTDDTNCATTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4N2</accession>
    <name>A0A1Y2B4N2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4N2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4N2"/>
    <dbReference type="InParanoid" id="A0A1Y2B4N2"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="59"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="242" mass="26390" checksum="99521A84D83B4A5A" modified="2017-08-30" version="1">MFRPLPTHITSRLTHHFRSTIICSTKLRNMSSTSPISAEQIPTLTDLYNQSQIPAASTTSSYSYEASLNSRVSIWRGDITHLKADVIVNAANKSLLGGGGVDGAIHRAAGPQLLRECMTLGGAETGQTKVTMGYDLPSKRVAHTVGPVYSRSNSERSAKLLESCYKTSLEACRENGGGVIGFSSISTGVYGYPVEDATKIALETTRKFLEKDDTVTRVIYVVFSKRTEEIYQELVPAYFPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4R8</accession>
    <name>A0A1Y2B4R8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4R8"/>
    <dbReference type="InParanoid" id="A0A1Y2B4R8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="164" mass="18302" checksum="5D4EE5967BED3243" modified="2017-08-30" version="1">MAIEFFFQGKTTDGTQPPDPRIMYSVCDPPTRRFAEVQWTELTEEDFRARPDSSTMTILNASFSTTTMRETGTRSESSNATINTNHERPPLLDWTCFTDETPSEASTTAGDPQRDLEADSTSFDADGQSRPASEGRYDGQTKSAEDRERDGYSWDTNSASKVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4Z7</accession>
    <name>A0A1Y2B4Z7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_531310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4Z7"/>
    <dbReference type="FunCoup" id="A0A1Y2B4Z7">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4Z7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4Z7"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="134"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="207" mass="24242" checksum="6AFB7922BAF30DEA" modified="2017-08-30" version="1">MEYDRELARLWRVSRTVHEMVRDRGYLVADYEISEDFESFKARQGGGQEVDRIKLNFSVDHRENEGDRIHVYFCGDKSVAKASIKKFVGDMENFKATRGILIHVEKLGGVANKTMQELQSEYHLEAFRESELLVNITNHFLVPKHTVMTKAEKQELIKRYRLKETQLPRIMLSDPVARYYGVKRGEVMKIERASETAGRYVTYRICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B559</accession>
    <name>A0A1Y2B559_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_168127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B559"/>
    <dbReference type="FunCoup" id="A0A1Y2B559">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B559"/>
    <dbReference type="InParanoid" id="A0A1Y2B559"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="102"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="380" mass="41117" checksum="59EEFF8834DD8F4A" modified="2017-08-30" version="1">MRISLSLLQRSSGPSSHSFSSHNHATYAIGLSYASKSSPPFVAPNSSPKRYGFAKHKTPIGHWVDYALSQPAGRGILSGGEPGGWGEEIRKEVERWGAGEDFFCIVDQQRTDESIAQSIKDQHVHLALSDGVGGWGDTVDPSLFSQSLMYHYALSATDSPSRTPIENLKKAYEGVTKDQGVPAGGGTGVGVRLGSDGEMLGVNMGDSGCLVVRNNTVLYETPSMTHYFNCPYQLSKIPPSMASGGMITDSLDDPKTYMKFSINLIPGDVILLYTDGLSDNVPIPHLTSLLTQIDALLSHPSNSHLGYIDRQKERARLFADVLVGYGRMAMAKTGQEDGVAAWKTPFQIEAAKHGYDFRGGKIDDITVVTAVVGERYPEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B668</accession>
    <name>A0A1Y2B668_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_530051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B668"/>
    <dbReference type="STRING" id="71784.A0A1Y2B668"/>
    <dbReference type="InParanoid" id="A0A1Y2B668"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012756508" evidence="1">
        <location>
            <begin position="18"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="13"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="399" mass="41545" checksum="1499341A507A8D2F" modified="2017-08-30" version="1">MKSTIAFLTLLFTLASATTYPRIESWSGDGFFDGFTFPASTYDNTTNGDVFWATAQNTSLLYVNDAGRVILKVDNTTSVVYNDKRYAPKLLSKTAYPPGTVWVMDAVHMPYGCSVWPAFWTQGLNWPLGGEIDIMEGINQVTTNQIALHTEGQGCLASTSNTASFSGTVGQTNCSTAANEDEGCIVTTTDQSSYGEGFAAAGGGVYVAEYAEDAIRVWFLSREAVPSSLTANTTSLDTSTLGEPVAEYLSSTCDFSTYFTSQILTIDITLCGDFAGVPALLAETCPALQGDATCYTTYVINDQQATYANAYFEINYVAVYQASNASTSSTSGSSAATSSVSGSSGATGTITAGAGSASASSSQTSTGAASGAFRLWMGDGATWAVLVGAGLLAGMGLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B677</accession>
    <name>A0A1Y2B677_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug resistance protein fnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_481308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B677"/>
    <dbReference type="STRING" id="71784.A0A1Y2B677"/>
    <dbReference type="InParanoid" id="A0A1Y2B677"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="79"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY30040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="608" mass="64028" checksum="3AB7C566D8001FA5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7I0</accession>
    <name>A0A1Y2B7I0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_572051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7I0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7I0"/>
    <dbReference type="InParanoid" id="A0A1Y2B7I0"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="17"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY30798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="350" mass="37422" checksum="F9C6DEED83FC7EF7" modified="2017-08-30" version="1">MGDIRYSQEVTADDCSYSINITVGQQDFSVIFDTGSSDLWLHTANFTCLDTNGVAVPVVDCSLGPNAYDPKLSHTFEPLPFANHIFIEYGNNQNVTGFAAKDDATIGNIRVNSTTFGLIDRGFHFEGDNVTDGIIGFAAPVLTSDYNGSDPTNNTLANLAVYLPWFYQAVKEKLVAPYFSVILERSTLEQQNSTQTVYNLGSVTLGGIPDVPVTEATVTVPNIKFIEPIDGRNQSVLLWDTVVVDRVNFPGSQDINTTISQSVIDTGTTLIYLDDNTASAINDAFQPPAVFNAAFGFAEVDCTAKAPALNFTIGGVDFTVQSEDLISVVEPGAGCISSVVPAGSGPQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7I5</accession>
    <name>A0A1Y2B7I5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_528416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7I5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7I5"/>
    <dbReference type="InParanoid" id="A0A1Y2B7I5"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="354" mass="39243" checksum="FE7DAFAED4852409" modified="2017-08-30" version="1">MPTVLITGITGFLAPYVALSFLTRDWKVHATLRSDSKKAAVEASPLGPYISSGQLELFVTGSLETGDYSKAIAGVDAVVHTASPVEFSDKDFETVHLAPALEGTKRVMDAAVKEESVKAVVYTSTYGAVGNHRIAPWAQAGVVLNEENWNPYTREELNDIDKNGWDPKKDFYNPGSLFYAGSKKYAELAAWEIKKTSGAKWSLASMNPTMIYGAPIQPQTSLSQGGMSTEIIYALLSGQDKPISPTYWPYYVDVRDCAEAHYQAVIKQATGRFLLAARAYDFQEIADKARELYPNEAYRICKGTPGKYTYKDPGVYILDTTRSREILGIKYRSFEDTTKFAFDRILELEKAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9K1</accession>
    <name>A0A1Y2B9K1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_526701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9K1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9K1"/>
    <dbReference type="InParanoid" id="A0A1Y2B9K1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="932"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123469" checksum="3076769167E83E09" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9T6</accession>
    <name>A0A1Y2B9T6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cryptococcal mannosyltransferase 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_527033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9T6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9T6"/>
    <dbReference type="InParanoid" id="A0A1Y2B9T6"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF1">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="522" mass="59775" checksum="E95D6AE1785FAB25" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9X0</accession>
    <name>A0A1Y2B9X0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9X0"/>
    <dbReference type="FunCoup" id="A0A1Y2B9X0">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9X0"/>
    <dbReference type="InParanoid" id="A0A1Y2B9X0"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="502" mass="54796" checksum="F8908DEAD42AFF20" modified="2017-08-30" version="1">MKPGSSSRRRVSAAINPLSYSRSARIIVITRSASSSTPSSSSSSSSFSTTSTSSSSASSSSSTKPSTTSTKSSTTSTVSSTSSSSSTKWKRPIKEGINPAYDAALTYLSSYQTKTLSKLSALQTKLASASEEDINSLREKIDQLEIEAYINDPAVRYEFKNTAGSRSMDRPVMRTLAKAKWIKQGGRDIIMGRIYQNRIVPDLLEDCPPSLPLTLSIKTSTGTGTGNGSGNSVGNGEDNDTSSSIEPGLILPTSKFTSAPTLTFQPFEHPSTPSTSNPNPTANYTLLVVSPDEPNSDTASYTERIHYLKTDIPLSVTTGDIDLFTGPGNEVFKWEPPAPAKGAGRQRYVFLLLRQNIDNALSTMPTSRANFRLRQFMRSNTLSPRSISAVHLFRAEWTVEEKTHIDTVWREYRQSPTGAPEYEQVELSDRMVRPLSAQQKRADQIRQRAWERAVEKAGGYLLGGGLPELNPGLANAIESVVERQMGELEQEQRDEDGKHVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB90</accession>
    <name>A0A1Y2BB90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_524837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB90"/>
    <dbReference type="InParanoid" id="A0A1Y2BB90"/>
    <dbReference type="OrthoDB" id="2563505at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="188" mass="19863" checksum="5C2B1B5B4DB1C8C7" modified="2017-08-30" version="1">MSDDEPIVHDDAGRPPSVGSYLFPLLFVILACSGFLYWRRRQRGATKGFGLQNLARTGPARVRLSMDDDGPASHSFISNNASTDSLPAHALQDLPLLPQSQSQIQDDHPARQSNPSSPIPGYTPPTRLSGHGGLLSGTGRRSARARGPVEGTDAEDEDSASDDSGGDAGAETVFGIGDEEEAEVASQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBC4</accession>
    <name>A0A1Y2BBC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBC4"/>
    <dbReference type="InParanoid" id="A0A1Y2BBC4"/>
    <dbReference type="OrthoDB" id="2585541at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="128" mass="13284" checksum="585DED7C77FC79EC" modified="2017-08-30" version="1">MGNCFSDPSSKPKSKPQGGQTLGSGPSSRPSPSQAGNNNNKQSTPQSLSSRTAVVPPQALGGAGVEPTGDARDNALRAAEERAKAAQTKGVNSANPKSGQLSKKLAEERRTPSGNQADERLMDRGQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDD9</accession>
    <name>A0A1Y2BDD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polysaccharide lyase 14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_492344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDD9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDD9"/>
    <dbReference type="InParanoid" id="A0A1Y2BDD9"/>
    <dbReference type="OrthoDB" id="10069995at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012237515" description="Polysaccharide lyase 14 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="3">
        <location>
            <begin position="160"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="335" mass="35930" checksum="49F46648C56B02F6" modified="2017-08-30" version="1" fragment="single">MTAPHFSQLFLLLSTLVALRAAPVIPDTESQSLLTYANTELALDASSTSTTPGVYDSTSSVPLDSTNPVLLNPQDTSEADSISSPSQTTWALPPTFSDMSPFNVTSYAAGKSNMAVLAGSPGQWTNMTSMSSANATTTPNDTAQAELFAEYTDPWEFSPNSLEILYPQGSINPGNQPQGGAEFYADPLDIAAAQNVSLQYSVYFPHDFDFVKGGKLPGLYGGHKGCSGGNAAEDCFSTRMMWRTDGLGELYLASLFLFLYVPKDKQSDSLCNTPPQSICESEYGLSIGRGAFTFALGDWTTIRQDVWLNTPGKNDGGFNIWANGQLVMSAGDVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDE3</accession>
    <name>A0A1Y2BDE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_522160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDE3"/>
    <dbReference type="InParanoid" id="A0A1Y2BDE3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="136" mass="15435" checksum="720CD6DEA96C79FB" modified="2017-08-30" version="1">MGWTVLLLCVWNDGPSKPSFERSLCDVIHPQEQSSSNCQNRVIFNLSPSTSAYLQVHYSTSLPCHAQSIKMRFGTSITETIYCRHQLIQTCTGRKATGRLATQGLCKPTEKRWFPDPGRNNQTIHFFKASKASIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE44</accession>
    <name>A0A1Y2BE44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_521261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE44"/>
    <dbReference type="FunCoup" id="A0A1Y2BE44">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE44"/>
    <dbReference type="InParanoid" id="A0A1Y2BE44"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="547"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="634" mass="66642" checksum="CD5545916C6D189A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEG3</accession>
    <name>A0A1Y2BEG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_492359</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEG3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BEG3"/>
    <dbReference type="InParanoid" id="A0A1Y2BEG3"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000092">
        <property type="entry name" value="Related to white collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="577"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY32867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="974" mass="104616" checksum="A5FB70114F35F4BD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF68</accession>
    <name>A0A1Y2BF68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF68"/>
    <dbReference type="FunCoup" id="A0A1Y2BF68">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF68"/>
    <dbReference type="InParanoid" id="A0A1Y2BF68"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="236"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="551" mass="61100" checksum="8FEA3F2D2521C821" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF80</accession>
    <name>A0A1Y2BF80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF80"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF80"/>
    <dbReference type="InParanoid" id="A0A1Y2BF80"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="280" mass="32030" checksum="BB78C4C7C9CF7D83" modified="2017-08-30" version="1">MDRERSPRRPHPRRSNSPERRDYETKGGGRSSSRNRSPGFYSSSNATRPPPRDSGYTSRDSRDRRRSRGDEPEGGYEWGTSGASKRRRGDEAYSEKDREKERAGERERFDVATKEGDGEVATVQVEKPNFGHSGLLAKETNTVKGVEMKYNEPPEARKPLKNWRLYVFKGKEQLDLIHIYKQSCYLVGRDTVVTDIPIAHPSCSKQHAAIQFRQISEKNEFGEVTTSVKPFVIDLESTNGTYVNDEEIPKTRYYELRNSDVIKFGTSSREYVLLHEDASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG18</accession>
    <name>A0A1Y2BG18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_267339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG18"/>
    <dbReference type="FunCoup" id="A0A1Y2BG18">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BG18"/>
    <dbReference type="InParanoid" id="A0A1Y2BG18"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="159" mass="17390" checksum="01D6650477C14AB5" modified="2017-08-30" version="1">MRAVIQRVLGASVSVDGQVISSIGKGLLVLVGIDRYDEPPDRALILKKILSAKLFDDQDGGSWKRSVKDIDGEVLCVSQFTLFANFKGAKPDFHESMSTIPGSAYYHAFLDEIRSAYIPERIKDGRFGAMMQVSLTNDASYIFISTSSSLSILDESTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG43</accession>
    <name>A0A1Y2BG43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_519175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG43"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG43"/>
    <dbReference type="InParanoid" id="A0A1Y2BG43"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000060">
        <property type="entry name" value="Related to DUG3-probable glutamine amidotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="397" mass="44483" checksum="EA13D96DD018861E" modified="2017-08-30" version="1">MCRFLVYKGSEPIQISHLVTRPRHSITNQAFESKLRLPSSRPMNADGFGIGWYDPLPPSPASAILPHQTPSPAPISRDSSPEEVADKQNGCAEEHEDGHAKDEEASKELLRKREEERELENERPCVFKSISPAWSNANLTRLAEKIRSPLVFAHVRASTMAGAPSEDNCHPWIFDRLIWMHNGEINSFPKIKRALQMSLSEELFLYPSGYTDSEWAFMVFLSKLKDPHARSFSHVELRNAMMETIRFINELSKKAGITGPSLLNFVVSDGQTVVATRYISSRTSEASSLFFSSGTSFDEYQEGGLYRMTKADKREDIIMIASEPLTFERSDWMEVKTNTMIVITPKMNVLQIPIIDEFWVPPQDPASQHRSTDFAVALGFGHGFASAQASTEVAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGD2</accession>
    <name>A0A1Y2BGD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_463286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGD2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGD2"/>
    <dbReference type="InParanoid" id="A0A1Y2BGD2"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017348">
        <property type="entry name" value="PIM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF72">
        <property type="entry name" value="CAMK PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037993">
        <property type="entry name" value="STPK_Pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="352" mass="39495" checksum="3B0487446532F3AE" modified="2017-08-30" version="1">MPSSSLAAEQHSEIAARYLHGHTLDSIFLAEYQLRDELGSGGFGFVCSAVQTGVGNVAGIEVAVKFIFKNRINEHDYTEVNGEPVESYVLRECDHPGIIRFLALFEDDQFFYLVQEIHGRPWSQNAALGCEVAQATSVPTLLQQHFLNPFSASPINHAMTLPGPLFERPGMARRASYDLFEAVEHRTFDEDQARHIFRQLVSAVQYMHARGMYHRDLKDENIVMDEHLVVKIIDFGSAVIENRLLSPVLHSQFRGTTTYAAPEVLNGESYHAGPADVWALGIILSIVLTGTSPFESTDHARCGRMQFKVPVSLDAEHLLGRCLRVDAARRATINEIAQHRWFRNGFAAMRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGU8</accession>
    <name>A0A1Y2BGU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_518221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGU8"/>
    <dbReference type="FunCoup" id="A0A1Y2BGU8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGU8"/>
    <dbReference type="InParanoid" id="A0A1Y2BGU8"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="55"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="479" mass="53157" checksum="55B1056AECE41F94" modified="2017-08-30" version="1">MTQIKSTPTNGQAPILAPFVNERVPGYHEFLPLQPQPIGSLLPADKFPQNEDPPKLFEPIEIRGVKFHNRLFVAPMCMYSADEGKPTDHHFVHHGSMAMRGWGSLMVEATAVVPEGRITPQDVGLWDDSQITSHKRIVDYVHGLRGHIGIQLAHAGRKASTLAPWVQRIAEDGGWNGGVVAREEEGGWPSNVVGPSPIAFDPKYPHPVEASSEYIADLKQSWLNAVERCKQIGYDFVEIHGAHGYLFHEFVDPISNKRTDQYGGSFENRIRLPLEVAKAIRAAWDGPLFYRLSASDWLEDVLGPEKAYPGQKEEWAFWGIQQTTLFVAKLAELGIDLVDVSSGGNDSRQKIKVQPAYQLPFAEHLKKHVPNVLIGAVGIITEPTQANDILEQGKADVVLLARQILRDIDFPLEAALELGAAVAPAVQYERAWSRMVVKREHTEAPVHHNGISEVEGEEGRSSERKAKRQPPPVVHQSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGY0</accession>
    <name>A0A1Y2BGY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_235050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGY0"/>
    <dbReference type="InParanoid" id="A0A1Y2BGY0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012643793" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8914" checksum="D882A25D1E5D4D93" modified="2017-08-30" version="1">MYPHLPLLPLLLPLPHLLEQLSPLTASTLVSSPSPSEPSVSTGFKAASFNPDILSETGFLNRMDITVSLFSVLTHHRPFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH30</accession>
    <name>A0A1Y2BH30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_518520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH30"/>
    <dbReference type="FunCoup" id="A0A1Y2BH30">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BH30"/>
    <dbReference type="InParanoid" id="A0A1Y2BH30"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="102"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113638" checksum="B093714A05170BDF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHH0</accession>
    <name>A0A1Y2BHH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_556623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHH0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHH0"/>
    <dbReference type="InParanoid" id="A0A1Y2BHH0"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="33"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="43183" checksum="15D3594EFD6D195B" modified="2017-08-30" version="1">MAMPALPSDASSTGAADASPTSDTSSPSNSGAKRNMAYWSVWSSIAKPSYAELENMTHMILSFVDMTTFDSFLYSSTGGFDQSTAGTLRGINPNLKVIGGVGGWAYDVPFRPASQTDSSRSAFAQQVKSFIDTFNLNGVDIDWEFPVYGSQGYKLPTSDPNARPRDDDDAPNFALLLQAIRSAIGSDKLLSVALPSRQQDMLAYTNSTIVALMDSSLDFWNVMSYDAVNRRDSLTDYHAGGIVINRTIDAYSSVGIAKNKMNIGYPTYARYFELSPDSNCSASNPIGCPIPVSEDGTGNDLGYVGEYTFDITQDSNTTVTDWFENIASSGTDSTDAQASAWYDEKNHVFWTWVSPSDILSSCQQYLPEVGGVFYWSWNSDTNGAAGGPHIDAINSCVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHI8</accession>
    <name>A0A1Y2BHI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative multi protein-bridging factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_192350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHI8"/>
    <dbReference type="FunCoup" id="A0A1Y2BHI8">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHI8"/>
    <dbReference type="InParanoid" id="A0A1Y2BHI8"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="155" mass="16326" checksum="FD2C9554C7A9FEA1" modified="2017-08-30" version="1">MSDFDAPTYIIGHKANSRPAVARGSDLNAAQRAGTIAGTTKVGGGQSKGPADHGRIAKLDRDDAPKPPEKIDPAVGKAVAQRRMAKIKPDGKAMTQKELATLINSKPQDIQDIESGKATPNQQILGKLERVLDVKLRGSDIGGPLHAPKKKVPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHJ1</accession>
    <name>A0A1Y2BHJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_586062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHJ1"/>
    <dbReference type="InParanoid" id="A0A1Y2BHJ1"/>
    <dbReference type="OrthoDB" id="2574480at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="752" mass="78351" checksum="CEBDC09CD11F9568" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHL0</accession>
    <name>A0A1Y2BHL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_517372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHL0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHL0"/>
    <dbReference type="InParanoid" id="A0A1Y2BHL0"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22771">
        <property type="entry name" value="OTU_plant_OTU7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="149"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="485" mass="53183" checksum="5F5213276C750424" modified="2017-08-30" version="1">MPELPHDLVSSSSLHPSPLLEDSFHASSSRLRRKRRKTDLPVYSSGSKPLSRTSSGLEDEYPPTGVSMTSSSSRGTYDTLPLLILLPDQVCQLPPLRLRGGGRRGKIRVKPGKRPVTRSVAQDFAPEVSLELISAEDAAVKRELARLGVGLRDVEGDGNCLFRALGDQLWGDQKRHPEVRKLVCDFLERRKEDMLPYFASIDESYDQYVARMRQFTVFGTGLEVQAAARVFQRDIRIVTSTSSFTVPWQREGSPEPPPADPADSGKPRRRTRSSTNNLLSTPSAPPPSSPSYASALAEYIPAVRPGRSMLWLALFSMAEHYQSVRRKGDGGGAAEIEDKLAVYHEMDNSEAARKARGEIVAGDSGTAYGRLVALLPPSHGLSTALIKATLGRTQNDIHAAHEILLEELALDDGVEDPKDKVSYREPSPTKSSTPTSSASHGGESTEPTTPEEVLGKPDDGLEELHDLKMKIKPQHKTRQSANRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHL8</accession>
    <name>A0A1Y2BHL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_193603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHL8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHL8"/>
    <dbReference type="InParanoid" id="A0A1Y2BHL8"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF74">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="235"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="594" mass="65777" checksum="63887C4BC596E9C5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHQ9</accession>
    <name>A0A1Y2BHQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_194875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHQ9"/>
    <dbReference type="InParanoid" id="A0A1Y2BHQ9"/>
    <dbReference type="OrthoDB" id="3364747at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="23030" checksum="CB319CE78DD5075E" modified="2017-08-30" version="1">MGLFGSSDPTKLAEKQIEKESKREESQLKQAIKDVSKAEKDEARAQKAEHHAHSVHDKAAKEEQKLRTEANKVVQKHDAATTKEKAAQSDIATKTNEHNRLQQEVERKKAALEQLQGKHHGNEAHRHERLAEIHKPTEGTANGTAATGTTGTTNGTGHHAPAGHDAGATTHAPVGHDTGAGTQAPAGYSANAASAGTTGATAAPTEEQRVVDAVHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIK5</accession>
    <name>A0A1Y2BIK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_513626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIK5"/>
    <dbReference type="FunCoup" id="A0A1Y2BIK5">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIK5"/>
    <dbReference type="InParanoid" id="A0A1Y2BIK5"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="421" mass="44241" checksum="FFE4ED797D3CD156" modified="2017-08-30" version="1">MSEVYQKKELLGLMNTGANKLCVDCNAPSPQWASVSYGTFICLECSGVHRGFGVHISFVRSITMDKWSEDQLKKMRLGGNEAFKTFMESYGPEGGYKIGMGMNEKYNSWAAAQYREKLTATCADPPTQFTSRPPPPDFGVPSRPASAQATRKSRAAGGISSSSLNPSRSGTPSSTGGGAGGGGGHEAFFERLGNANNSRPEHLPPSQGGRYAGFGSTPEPEFDGDSSNPAFALSSHNAPSWDEVQRNPLGAITKGWGLFSSAVAIAGKEINASVVQPGLAKGQDLIGGEGSQELQKYLASAKTAADWATERANEGWNGINEVAKTRGGVDLNEKLGRLGLSSRQDSGYGKLERAEDGALSPHGGGAGAGSSDFFDSWDSQPTPTSASTSSSTVSKSQGAQPAKAKGKGKDGWGEEDEWKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ30</accession>
    <name>A0A1Y2BJ30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_518502</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ30"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ30">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ30"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ30"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="518"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="920"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1017"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="350"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY34105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1198" mass="132972" checksum="7BFB5FCADD472944" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJA1</accession>
    <name>A0A1Y2BJA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Choline/Carnitine o-acyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_513842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJA1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJA1"/>
    <dbReference type="InParanoid" id="A0A1Y2BJA1"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016406">
        <property type="term" value="F:carnitine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="63"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="745" mass="83594" checksum="982787C7EABF9FF8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJE2</accession>
    <name>A0A1Y2BJE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_515384</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJE2"/>
    <dbReference type="FunCoup" id="A0A1Y2BJE2">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJE2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJE2"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="305"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="602" mass="67197" checksum="68AF2ECEB123C23A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJY5</accession>
    <name>A0A1Y2BJY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_516690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJY5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJY5"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012530869" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="38480" checksum="2648FBAD13893C27" modified="2017-08-30" version="1">MLSITIKRLMLGSAYLLAVAAAPLARSTAATVSPQLASATLLGDVVDPNLQRDSCGSVKWDTRVLWTCRDTEILVNQSVSLLVYNNTLAAFISSSASYTNFKADGTPDVVAVDYDQYGYDDELIMYGDNGETSFYPLQSDECNSNEAGNCNDGTRFALWPSVPPTIASQSSDGTIVAYTFIRVEHITDTLGVVNPDPPTSLYRLDYSPDVQGVGDTLPSVSLVDEEFWSLNAFAYGDYGTVTHDGYMYLYAETSAYNIALAKVALGDVEDKTKYQYYVDGNWSSTPPVNVNDTSAYLDHPGAGGQGTYYWSSLWECFVRKTRRGVTTLLSTPRRCISSSLNSLENGRFQGTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BK75</accession>
    <name>A0A1Y2BK75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_516195</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BK75"/>
    <dbReference type="FunCoup" id="A0A1Y2BK75">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BK75"/>
    <dbReference type="InParanoid" id="A0A1Y2BK75"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="500"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="841"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="924"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY35020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1095" mass="122326" checksum="5DA23754D1B6629B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKE0</accession>
    <name>A0A1Y2BKE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alginate lyase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_513398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2BKE0"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alginate lyase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="370" mass="42432" checksum="81D6F0A891B8C792" modified="2017-08-30" version="1">MAKPLPIPSYPAKIIVPTPRSDPSAQALKLLRQQARSILESKETYSVTFSPVLCPEGKNHFFTLQPYMWLRKDGNWEKRDGHRNPYCDLPKGQQQLSEMSRIVLTLALAARHLPERKDAATQRMHELLEIFFVNPETMMIPEVRYSQCNPGETPLKGNSAFIIAIRNLILVTQALRVTSVDSVLDQQLGRWFQIQIEWMTSSDQGKEVANCGDNKEYWYHAVMASHYAYVDPSRAITYAINYLNTLMTRYPEPAAFFAQDLNRTRPRHYTLFALEPTFILVDLTRVSPLPPPAHILTYIENLIDFAHTVKPGAIEVPLEMEGRYERQIAWFQRMLAAWKGSPVGSGGDLPDGEGWSKGWDMWMRTMWGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL20</accession>
    <name>A0A1Y2BL20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_9041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL20"/>
    <dbReference type="InParanoid" id="A0A1Y2BL20"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="176" mass="18669" checksum="47CDD3661B079BAE" modified="2017-08-30" version="1">MSASASNTVQSSSHSKPPKADLQVSVWYGYEGRPSGILETSFTNDSRINEDKDDMLAEVTPLLSEDDYKTKVTEATIVALSGKRLKGGAQLGTATRSTLKSALDRRNKTHDVQWTCKGGSVSIKKGEELMPTQQDATASTGFQNVLDAAWTAACAEFSGGTQTGRTQTEGGPSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLE4</accession>
    <name>A0A1Y2BLE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative cytosolic Fe-S cluster assembly factor NBP35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="12" type="ORF">BCR39DRAFT_510591</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLE4"/>
    <dbReference type="FunCoup" id="A0A1Y2BLE4">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLE4"/>
    <dbReference type="InParanoid" id="A0A1Y2BLE4"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="336" mass="35717" checksum="6A2C7F0CA189BC6C" modified="2017-08-30" version="1">MIATQRPLPIPSPLPIGPSSTLLPSTVPENAPEHCPGVESSQAGKADACEGCPNQAVCAEGPKGPDPDLPLIRERMRSVRRKILVLSGKGGVGKSTFSAGLTWALAADEECQTGIMDVDICGPSIPLLMGLEKSTIHTSASGWSPAYALDNLAVMSIGFLLPSSSDAVIWRGPKKNGLIKQFLKDVEWGPLDYLVVDTPPGTSDEHLSIVQYLQEAGIDGAVLVTTPQEVALQDVRKEIDFCKKVGIPILGLVENMAGFVCPNCKTESEIFTPTTGGAEGMGKELGIELLGRIPLDPRIGMTCDQGLSFLDEYPESPATAAYLDIVQRIREILGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLK3</accession>
    <name>A0A1Y2BLK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_23363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLK3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLK3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLK3"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013367857" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="210"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="430" mass="45484" checksum="204F0117B96049C8" modified="2017-08-30" version="1">MHLLALFVVALWPLPLSLSQLELPDCPDTSLTDYLVALIDALYANGLTTFESLITSLSETEGGYDLLSSWYNSQSTLTLLAPTDTAFQSAGITPPFKHLSEWEMVNLMSLHTLDGQWDYEKLPAYPLHSIASTDLVLAEAMNSTVNTTASQVAVLQQAQDGGNVVQVKADNVTAKSWSGLVNLSAASQLWNLQVLPIDSVLPLPPKLSVALTLPTSSRSANGFNNLTSLLSSSSTSPSMSDLEALTVRGFTIFAPVDDAWENPDVKVALNDSTLASNHYTTTYSLYSTAWYGPGQFLNLTLDSGASVDVVYNNSGNFVVMGDQSTQILRSDVLLENGVLHIIDKVLLPISSTPTSASTSPTSGNARPSESVPNAPTGPIQPITTPSAITSGNSTGSVPGEKDAQSSGAGILAVRFWGVVLALSGTFLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLN6</accession>
    <name>A0A1Y2BLN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short chain type dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_21628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLN6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLN6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLN6"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="229" mass="24742" checksum="1A19AB2A3AB84397" modified="2017-08-30" version="1">MAAKAPVVLILGAGPNIGQAVARTFAAKGYKVGLAARSVKEADSTDVQLNIPSDFSQTDDVVNAFTKVKKAFGIPSVVVYNVSASHFSPADDPFALSLTDFNYDAAINIHSAFVAAQQAVRGFEQLPASASRTFIYTGNVLNVAILPRFLSQGVGKSGAAHMIWAASAAYKDRGYKFYYADERKADGSPKYRVDGDAHATLFWELSQAEKQLPWMQTFVQGVGYQKFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM02</accession>
    <name>A0A1Y2BM02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_34176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM02"/>
    <dbReference type="InParanoid" id="A0A1Y2BM02"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59309" checksum="B8BE98CA1415B563" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM74</accession>
    <name>A0A1Y2BM74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_568631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM74"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM74"/>
    <dbReference type="InParanoid" id="A0A1Y2BM74"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012237486" evidence="5">
        <location>
            <begin position="23"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="6">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="685" mass="73427" checksum="8BB64F5B2B15FEB7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADH9</accession>
    <name>A0A1Y2ADH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_555207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000131">
        <property type="protein sequence ID" value="ORY20572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADH9"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADH9"/>
    <dbReference type="InParanoid" id="A0A1Y2ADH9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY20572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="482" mass="53117" checksum="07E2924F8AC969C2" modified="2017-08-30" version="1">MTTTTDHTDRITTRTTATSTHIVVLPYPAYDNLHPLLHVIANLVLLSPDLHFTVLLPPSAAQHADLVFHSPAMSHINGRNASNDNIVLRRAPVNRIHLVPVQANPNPDQPPPPYHILTPVSARVEMQRFLTALPQALAPLFDLDSESEGFERRPSSFLLDLALPALLQSINRLVHNEIIPRIPINGYHTASATGLVTVLGEQDDYNTTTTEGDDIAAAYASAHDPAISTVILPTYTELETTDALERLEEELDKPVIPIGFQYPEWMWGTEPMTLEGVLPEDEFLGVQQFLDQSTARYGHGRVVYVDLDRFPAAASAVLPALFDLGPPLFIGYSRPLPGVIVDIVIRMKESPRVYVTALRPGRGSRCVILRQPAVGLLVSECCLASVARAIVCEKPLLAIPTSFSDALSTHLKSSFGIVLDLPVPSAHRPEQLFRAQLSSLWSYVEAWGGGELRTRLTRLREDIVRAKREGKGMRELATRLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF86</accession>
    <name>A0A1Y2AF86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_554192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF86"/>
    <dbReference type="FunCoup" id="A0A1Y2AF86">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AF86"/>
    <dbReference type="InParanoid" id="A0A1Y2AF86"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="5">
        <location>
            <begin position="101"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="564" mass="61570" checksum="7EA0366A3ADD66D9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFI3</accession>
    <name>A0A1Y2AFI3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_65695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000114">
        <property type="protein sequence ID" value="ORY21301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFI3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFI3"/>
    <dbReference type="InParanoid" id="A0A1Y2AFI3"/>
    <dbReference type="OrthoDB" id="2574995at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="534" mass="57581" checksum="63033DAB511595F6" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG57</accession>
    <name>A0A1Y2AG57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_553529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG57"/>
    <dbReference type="FunCoup" id="A0A1Y2AG57">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AG57"/>
    <dbReference type="InParanoid" id="A0A1Y2AG57"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-Gid-type" evidence="11">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY21462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="416" mass="45274" checksum="F53D7FB89901CC3D" modified="2017-08-30" version="1">MEISAALTALESLASSPSTSSSGPLTILLDKHFSTARQKLLSGEDAALVLSDLQKQVTRAKKDVEKGLKGWYGALGGVGKAVEKAFPPNLAGISEAYDDPPLFVREEAREALDRAVMDSMARRGLWEAVAAMEEETGQIYNDEKRSLAEELGRIVGDMENGELSSALEWCNENTAFLRSPPHPSSLPYYLHRTIFLSLPNPSEAMTYARSHLLPFLSTHPVLELITSRLYIPPVSASTSTASSSSYPSGHNPSTSLEPPSNGVVDVDMGKVNPYPSVNGENEVSLINMFRGEYCRRHGLPKEDPLGVAVDLGGRGGALAVVEKARRVMGERLGNIRAWEELPMEVPLPASRRYHSVFVCPVSKEQATESNPPKMLTCGHVLASESFDRLLKGGRRSAKCPYCPVETSQSAAQRLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGA4</accession>
    <name>A0A1Y2AGA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_508323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000107">
        <property type="protein sequence ID" value="ORY21638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGA4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGA4"/>
    <dbReference type="InParanoid" id="A0A1Y2AGA4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="239" mass="27190" checksum="09CB25A78E8B0B3B" modified="2017-08-30" version="1">MTRKPGKHGGKWAHKETSPSQSKEVATRFAQHKIYEWHSTLPVILQLHYDTPKVVNHKQNYDHIAEYLYTQLALHNSKQLQPPPGDFSIAHPSPPIGEPKYLVICLRSWYPPQHDTSRKIMKALDECYEAGVSPQTKKDGQNPDFHSNHFGILATPNLYLQVQIQCFIKLKQSKHQPTLKRLNPETFVRMLGINHKLSQASANNSGPHKHKDLTEHGRFLSIGFNSMVAVSEGSAANWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGL4</accession>
    <name>A0A1Y2AGL4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_553237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000107">
        <property type="protein sequence ID" value="ORY21646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGL4"/>
    <dbReference type="InParanoid" id="A0A1Y2AGL4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="234" mass="26597" checksum="64D5D4A558BF40AB" modified="2017-08-30" version="1">MGYIRPENFRKGCLRNSFLSTMPSYTATGTPLRLPRHSLCVSDRSPTPHPDSYKRSGSTEPSLKSLKAWYISRFESTVHDLHREFLEKLGAAVVNPTVSARLFLEIGQYRIIKARSVTNSLRELHTIDGDSNVESRHNASNQQVTTFDFDDRDDQAAISEEDSNLVHPAFGHEHQDDSVTRSKKRRRESYDISAISSRSKSKSRKEHDPQRDRRPAKKVTAGEAMAISREKIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIR1</accession>
    <name>A0A1Y2AIR1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">And other transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_567103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIR1"/>
    <dbReference type="InParanoid" id="A0A1Y2AIR1"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="96"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY22180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="541" mass="59936" checksum="39AC5315CBDC601C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ55</accession>
    <name>A0A1Y2AJ55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_474027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000096">
        <property type="protein sequence ID" value="ORY22227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ55"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ55"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ55"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="5">
        <location>
            <begin position="231"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY22227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="428" mass="47819" checksum="9610F4AC5E762CB4" modified="2017-08-30" version="1" fragment="single">FYVSTDDIFDDSKWSDAVYFDEVGFDQDLLFDDDGKVYQTVTRFDFTADFTDGKPKIQSWINEIDLASGRSLTAPVLAKASALGVAEGCHIIKHEGYYYFFTAEGGTQSGHRECVYRSDSPLGPFHPPPDGINPLIYNGDHPDIQNTGHMDLIQGDGGRWIAVFLGVRPVFEAKVDVTGTKGMPTHLGRETFMATVEWVDGWPVVNNREPIELVGKAKGLSLLPEARAWVDDFSAIELQLGWYRVHVPLRSFHDLRKRPGSLAIYGSATTLDVDHSPSILLQKQPGFIGDWSTRVGFTPTQPGQEAGTVVWLHSKAYAALGIRGTKEGELEVFFRRPNAEGKHEVSHRVDSIPDRLRMTLIIEARQLEYTFKYQMDSTVKEAGRVPTSSFHPLFTGVHLGLYAQGAREVPCLNPAYFEYAKWDVPSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJK6</accession>
    <name>A0A1Y2AJK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_550937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000089">
        <property type="protein sequence ID" value="ORY22684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJK6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJK6"/>
    <dbReference type="InParanoid" id="A0A1Y2AJK6"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28763" checksum="95E607A5F4BA48D0" modified="2017-08-30" version="1">MTYLTPHLPFSGSTPALPPPKSYLIISDTLQSPAHWALYHLFAAAISEQRKIVLVDFRNDGRASLEAVLRKLGTTLPSQPDLFTHIFPSSFPNDSPSAPSLFTSNDAPTLRPTYQVISESLDSGALVVLDGLSDLVNIGFSVPEVGRFVRAVLSLVRNSRASLVSTLHADELLSSSVSTSPPSNSLDLLERLLRIGSIWWRVQQLSTGRSSDVHGEISCHILSPPTEDRHGWTQVPKANPLQYRLEERTVRVFPKGTGRGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJU5</accession>
    <name>A0A1Y2AJU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_550753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJU5"/>
    <dbReference type="InParanoid" id="A0A1Y2AJU5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="112" mass="11626" checksum="A7B524F0E91263ED" modified="2017-08-30" version="1">MHTCGKYRVIHTYIASRCFTTSDSRVPGHVLTHPAPLLSRLECVPTQLLLVPRPGTRPYSAPPSPSPGAGPYSAPSPSPGARPHPAPPCPSPGARPSSSTPPSLPSCVRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKN6</accession>
    <name>A0A1Y2AKN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_487418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKN6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKN6"/>
    <dbReference type="InParanoid" id="A0A1Y2AKN6"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="147" mass="16491" checksum="0EBEAAEB64E115A1" modified="2017-08-30" version="1">MPRLIPRFTSLLPPRTLQPSLVSVSATSTPRITSFQLPFTRLTPVSSSSASSSPSLTTSSLLPLPPLPRQIVSPTPLFNPRLSLLTTLGATHPSQLSQVRFTTYGQEYQPSQRKRKNKCGFLKRLRSKSGRAVLKRRLLKRRRFLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL85</accession>
    <name>A0A1Y2AL85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SUR7/PalI family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_549650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL85"/>
    <dbReference type="STRING" id="71784.A0A1Y2AL85"/>
    <dbReference type="InParanoid" id="A0A1Y2AL85"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011965712" evidence="6">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="243" mass="26020" checksum="CF7A17640175D1EB" modified="2017-08-30" version="1">MAIGPIHCGTFLLFAATILLLVATISAPVVDKIAFLDINSGAETTSFGVFGYCLRPSSGADQCTGSHVGYDITTVTGTITSHSWVNKSIHGLTKALILHPIACGLSFIAFIVALLSSQIGFLFASFLAFLAFLVSLASMAIDFALFTIVRNHINDNTTATASFSTAIWLVLAATVVLFFSVFIVCFSCVTGRRHERDNHSRGGIGNNNATGGYYGNGGYTGDQVMMDEPVGKRHFWNRNKAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALB8</accession>
    <name>A0A1Y2ALB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_566883</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALB8"/>
    <dbReference type="FunCoup" id="A0A1Y2ALB8">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALB8"/>
    <dbReference type="InParanoid" id="A0A1Y2ALB8"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="116"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="216"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY23369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="313" mass="33607" checksum="76B28DAE0EEFA6CB" modified="2017-08-30" version="1">MAEVVKKPKDAKAFLTDFLMGGVSAAVAKTAAAPIERIKLLVQNQDEMIKQGRLATPYKGIADCFSRTYADEGVVSLWRGNTANVIRYFPTQALNFAFKDYFKSLFGFKKSEGYWKWFAGNIASGGAAGASSLLFVYSLDYARTRLANDNKSSAKGGTRQFNGLVDVYRKTLASDGIAGLYRGFVPSVVGIIVYRGLYFGLYDSIKPVILVGPLEGNFLASFLLGWGVTTGAGLASYPLDTIRRRMMMTSGGAVHYKSMVDAGSQIIAKEGVKSLFKGAGANILRGVAGAGVLSLYDKMQELVFGKVYSGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALG3</accession>
    <name>A0A1Y2ALG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_549198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALG3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALG3"/>
    <dbReference type="InParanoid" id="A0A1Y2ALG3"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="439"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY23419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="699" mass="77506" checksum="A668A1BA9B2A261E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANS2</accession>
    <name>A0A1Y2ANS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_472609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANS2"/>
    <dbReference type="FunCoup" id="A0A1Y2ANS2">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANS2"/>
    <dbReference type="InParanoid" id="A0A1Y2ANS2"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="79"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="459" mass="49893" checksum="85A51DFA5D74A620" modified="2017-08-30" version="1">MSQYRTIYHGNFIHTPTPAKLEVLHSALVCVGPEGVIEWIEEDVQGEMIQDISGRYGIDLLDGAATAAVQVVQIPQGEFVCPGLVDTHTHAPQYPNIGLGGALQLLDWLEQLTFPEERKFADIEYARQVYGRVVERGLGFGTTTCCYYATTHVEASLALAGICLERGQRAFVGKCCMDRNCPHDYVETTEDSIQDTEKFLSAILSTSSSSSKSLAPLVQPILTPRFAISCTPQLLSSLASISKTYTPPLLIQTHLSENLAECDVAAELFPDSKSYAAVYADHGLLAPGTILAHCVHLSDEEMDLIRDTGAGIAHCPNSNTHLSSGCARVRTMLDKGVKVGLGTDCSGGNSPTIMTAMRHASDVSRFRSFVDQSTSSLSLAEIFYLATMGGATLCRLDQKIGSFAIGKEFDALHIRPVSPTLWAQKGDSEERLFERWIWGGDDRDVADVWVRGRRVAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ05</accession>
    <name>A0A1Y2AQ05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_547321</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2AQ05">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQ05"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ05"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="393"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="289"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1407"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1448"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY24297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1726" mass="192139" checksum="35EA332DDB3147FF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR18</accession>
    <name>A0A1Y2AR18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_561571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR18"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR18"/>
    <dbReference type="InParanoid" id="A0A1Y2AR18"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="53889" checksum="CBDD5255C5782E57" modified="2017-08-30" version="1">MTPPPLPPTPRRKERKEGDIGSVFASLSGEAEAVLPPRFLDLKRSIIGDEANQAALRKGWASLTRRLAQRADEIEAKQQAAITYEEFIERPSKQLIDEIKSCGTVVVRNVVSEEQALKWLDEIREYVKLNPQVKGFPADDKQVFELYWSKPQLAARAHPRSMAVQRALLSLFSRSPDTPVSLETPLTYADRLRIRNPGDAKFALGPHIDGGSIERWEDPTYRSVYERILRGKWEEFDAWEIGARGEAKQNMYDGAGACGVFRAFQGWTSLSDTGPTEGTLRVYPFIQEMSAYTLMRPLFKVIQSRAELSHDAYLAPGNWELDLETSRFPGSPLARGQELNDDTHPHLALSRTMVSLPRVKPGDQAWWHCDVIHAVEAEHRGTGPSAVMYIPSVPLTAQNAEYVRDQRESFLAARPPPDFPGGVGESGFQGTGREEDVVGLAARNAMGLDAFDFHEGLSDDERAIREKDERAIREKANVVLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR57</accession>
    <name>A0A1Y2AR57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_561240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR57"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR57"/>
    <dbReference type="InParanoid" id="A0A1Y2AR57"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="270"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="272"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="662" mass="70928" checksum="B87643833C77A351" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS10</accession>
    <name>A0A1Y2AS10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol N-acetylglucosaminyltransferase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_544646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS10"/>
    <dbReference type="FunCoup" id="A0A1Y2AS10">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS10"/>
    <dbReference type="InParanoid" id="A0A1Y2AS10"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="374" mass="41264" checksum="41FEA360CC2EEB32" modified="2017-08-30" version="1">MSSKKASKRRQVTHTESSNPTEEAPGPAVEWEKALWKRQPFEDNYVPSTFLHDLQHLPSRPRPSLNTLFFSALPISQHLAVIALFIAIFYALLEGSLDAAEVGWTCVVLGIAGYVLRRWGWRDSLPDDSSLNQTDKGILPPPTAIRPLLLPPLLLSLLAPVLGTLTSATTSDTIWPLAGGLFFVHLLLADFTTGKDARRRRRELRRREETRRRNSVSSLHVEVEIVEEKSLTSSLSLTSALSASIVLASRLKSTSQVFSLVLLSVALFAGWPILAKGVRESGRIFSLALTSSMIILAISLFPRISSNPPSPSDPTPWISIPTPSGPTLIFLVAVILVNGIGPGMLWYGWRWKMRRGGGWDVAVVRLRRVRDRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATZ7</accession>
    <name>A0A1Y2ATZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_272825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATZ7"/>
    <dbReference type="InParanoid" id="A0A1Y2ATZ7"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000394">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="493" mass="54367" checksum="F08EE4F6FC87F5FE" modified="2017-08-30" version="1">MSAASENETQKNNEEWHEGEDTVDPAILELAAQYVPGSDAEKALVRKIDKRIIPCIWGLYTLSYLDRANIGNAKTGGLQKEFGLTSTQYSICLLVFFISYVLFEIPSNLFIARVRPSLYLSGLCVLWGAIAACMGATNNYQQLAAVRFILGVIEAGFAPGVAFYLSSWYRRYELASRFSLYYTATAVSGAFSGLLAGLITRHLDGARGIAGWRWLFIIEGCGSSTLGLFTWYFMPDWPSTTRFLSGEERVLAAQRLAFDGVASTAGAQGHIGHLQAIKMVVVDWRSWMFVVLYMLCTGAQTIQYFVPTLVASLGWTGYLGQYRTIPVYASAFTFILTFCWGADYFKKKPQAISLAATIAAICFIIVTTVRHHMVQYVFLIFAFGAVYALPPLILTWVPNVIGFPAEKRAVAIALVNGLGNSASIYGVFLWPSKDAPRYIPGFSATTVWVALVAILAQVMAYLVNKYPVEAPDADKVVMNEIENQRAKGRLQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUJ3</accession>
    <name>A0A1Y2AUJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_542008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUJ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AUJ3"/>
    <dbReference type="OrthoDB" id="2575758at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="562" mass="61959" checksum="26C9D183CF2445D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV49</accession>
    <name>A0A1Y2AV49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_506655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV49"/>
    <dbReference type="InParanoid" id="A0A1Y2AV49"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="347" mass="37017" checksum="6817E541D5D91BD2" modified="2017-08-30" version="1">MTSDPPHYYALCDALREVRPAEVQSGDVQGGENQGDDDIDMEDPDGEEPPGTPYSGDSNASTTPRATTLDPDAESDGGTATPRPGDPDTNMGSPGLNAEDEQVEEGEEGEEGEEDEEDEAGPAYDPWKEVFETGDDDQVRADGTTKASSSSSPAKASQSSSASDSTRRDTRTPVRGSLLYWKGAAGKRGCTAGSFTKPSSVLSQWSVCPGPTAKYEWVEVGDGLVHSLTGNLCSSHAEQLKGPDSTFWLGTERELRSSLASDDTAPPCSIPGCTTVSRTWTRVRGKEVDSIVLCDEHAEETAKSDGGMATQSSEQEDPGRFAAFWNSPVPQQYQNLSHGEQQEMMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVA3</accession>
    <name>A0A1Y2AVA3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVA3"/>
    <dbReference type="InParanoid" id="A0A1Y2AVA3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="318" mass="34785" checksum="0BB4F1A56E699CB4" modified="2017-08-30" version="1">MPLYQASAIDDDDLADSYEVLMILCESSAADDDHELVEVSNKDTYTALSDSGLDMDVDPEEDMSAESSVFVPIARDGLSDDGRVYDGSDSKVYQQARTRASEVSDNKTINASSSSPAPNTSQSFSAPAQSTKAGSLVYRLEDPVSEGRCSVGVFATYGCEFPYQSYVKWYDGRSGTVMLESAEKAAEEAMLCRGHWDKLRSASHVSLNSLCQLQHIPASSQTAHCCTWKSCSADGHEWTVQDTSKKKNYTIDLCDRHAYRLARGDSPTANSSSNHDNRFAAFWTQPPPAHCGASEATNIMWPGDTLEKMDDGLRKKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVS6</accession>
    <name>A0A1Y2AVS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_560593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVS6"/>
    <dbReference type="InParanoid" id="A0A1Y2AVS6"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="146" mass="15987" checksum="236AFBA9910E33B8" modified="2017-08-30" version="1">MSTSSPATPSDAAVSVAKVDVAVLSMSSNVQAAQPNKSKQSPLVMQIILRRDLETVHDWPIGPLLAQSAHAATAVLHLHAQDPNRHRLPDEGALRSLAERLKQEQVGYHMWIEQPEDIPTAIALVPNRRPKALKKLLDQAGCTLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW60</accession>
    <name>A0A1Y2AW60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_506606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW60"/>
    <dbReference type="InParanoid" id="A0A1Y2AW60"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="172" mass="19090" checksum="318F12BD97F94A79" modified="2017-08-30" version="1">MTHVSSLAQFDSLKKFVVVALIGLSDQRVAYSIASSLQHGKKLPSALSASSQTSDWARGTRGRFRRFWHLQQTLTKITQRRPKQTAVSVVDKVELLIDISTISADKRQRKARRALFNIPIKISQSVEGLGWRVSERPLDPLEPAGREIDRSYLPDVCSAPSFSATGKSTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW68</accession>
    <name>A0A1Y2AW68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_540463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW68"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW68"/>
    <dbReference type="InParanoid" id="A0A1Y2AW68"/>
    <dbReference type="OrthoDB" id="2563749at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="510" mass="57075" checksum="00D86E7CA387041D" modified="2017-08-30" version="1">MSSQPLNLHDATRVDFPIDPNLQDDDDGLFLPEDPDVIQPPAPSQADFDAVEAITASLKQANEASIVGSGPLLTEDGGVPGDQHNIIHDPRPLIAPFVKPDRSDDTPHPEYIMFSSRVLFEAWIKGESSWCHFVQRRTTTPDKRSVERMRARERAHERSLANLPPEEAASAPPLKKRRRGRTSNIAEKITFTCHHAGSYNPQHSSDLPKEKLRMNTKKTVKCGCQARIVFTEMNEGDCKVLYYWQHQGHDPFAEDEWDTGKLPRVVDDWLMEMIAKGKDLAQIKAALTITEEEKHQLMERVINDPNSLDPNAPPPLAFHLKINYPDIYNRYRKVKGPIKATKVLKGKKRVIKMSQDTSPTPGVMSDHAHIGVLDSSTLPSDATLHTTGPPSHMETDIDPALRLSIATAEREGVAHQFLDERNHRHTTTTTEHHHDVEGDEMPMPMTDEQINEGFAQLAQEGHSDLAQALLRLPRGTIDGDGDDVQIPEEMLRMAGIGEGVVGETWSFDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWP0</accession>
    <name>A0A1Y2AWP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_246598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWP0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWP0"/>
    <dbReference type="InParanoid" id="A0A1Y2AWP0"/>
    <dbReference type="OrthoDB" id="2561042at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="547" mass="61440" checksum="3C9D63D0D6628A10" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX05</accession>
    <name>A0A1Y2AX05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Imidazolonepropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_246021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX05"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX05"/>
    <dbReference type="InParanoid" id="A0A1Y2AX05"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="98"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="503" mass="54633" checksum="31B5107843B75D94" modified="2017-08-30" version="1">MNRKAETTKQQLTISSMPDLKFRKPVPVNIELKNRNPGIDPQFVIFKEANILDSTGKEPYVGDVLIDGERFAQVGGEVDPAQYPEDNTLVVNAKGKTLMSGLCDSHTHLTWNDAPTLNGLCDLPNEEHMIHTVVSAKCYLDHGFTMCFGAASAKKRLDVACRDFIQAGKIPGPRYLANGPEISTTGGAIIPGITLFADGPDEMRKVVRDLMTIGVDNIKLSMTGDYVHPTMGSTETYFTQEEVDVAVEEAHRHGKRVAAHARAADSVVMCCKAGVDVIYHASYCDDEGMKLLEQQKDRIFVAPAINFPLLSTTSAAGYGLTPEMAKKRGLVHEVEAASKAMNAMYKKGIRVLPGGDYGFAWAPHGTYARDIDHFVRLFGYTPMDAILAATALGGEIMGHPEELGKVQPGYYADCILVDTPDVLADVRVLQDTTKIHGIFINGHKHKLSETPAPSYNPAEVTQKNGVKEPNESSNGHANGVNGAHKGTSDVANDSQARLEKEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX17</accession>
    <name>A0A1Y2AX17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative arginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_483872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX17"/>
    <dbReference type="FunCoup" id="A0A1Y2AX17">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AX17"/>
    <dbReference type="InParanoid" id="A0A1Y2AX17"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012982818" evidence="6">
        <location>
            <begin position="19"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="393" mass="42584" checksum="8C8AB5D4B3C82909" modified="2017-08-30" version="1">MIALSVLTCAVLVSTVFAHSPGSPSRIDPWNDDYANTPDLSFSGVVSFAHLPHEKCLDRPESAFDIALLGVPFDSAVSYRPGARFGPNGLRSGSRRQRPDRGYSSRLEINPYASGLTLLDCGDVPVTPFDPAAAIAQVNAAYRSMLHHPVASEEAMKELNMQKGLDGQYHPRIVAMGGDHTIVLPILDALHEVYGPVSVIHFDAHIDTWNPTRYIGSVSLQADVNHGTFFWHAYEKGFIKPNASIHAGIRTRFSGPEDLTDDVTAGFDLIHTFDIDDHGVDWISNKIKQRIGKGPVVISLDVDVMDPSYVPATGTPESGGWTSRELRRILHSLVGLNIVAFDIVELAPAYDSNGEISAIAAADMVYDFLSILALGVDAQSIEGKTGGRPTDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX43</accession>
    <name>A0A1Y2AX43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dynein light intermediate chain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_540856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX43"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX43"/>
    <dbReference type="InParanoid" id="A0A1Y2AX43"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY26475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="563" mass="60937" checksum="BD246C05DB0136FD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX49</accession>
    <name>A0A1Y2AX49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_446757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX49"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX49"/>
    <dbReference type="InParanoid" id="A0A1Y2AX49"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="165" mass="18298" checksum="009F0C75FD641B04" modified="2017-08-30" version="1" fragment="single">SVRVSIAWSGAEPIEDTDTLVLTIDGYSLDLRVFVDGPDRGSIDWSTVAHVKEVEGSTAKNPILRWDHIIDSRPPTDLPDQGIFETLSNEDVTETGTMYNPKTTLYEPYVETWRRLPQATGVPYLVLRLDKSSLVHGRAGVAFLGRVGPHALGIAKTDDGRFYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXY8</accession>
    <name>A0A1Y2AXY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_538451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXY8"/>
    <dbReference type="InParanoid" id="A0A1Y2AXY8"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="77" mass="8276" checksum="E77938E07BE2CF0B" modified="2017-08-30" version="1">MSDKSEEQQFTIQPHPAKTNNPSDLTSEPAEHGGLQSASANAYNARGPHVPTKEIAQGLEKPKTHDELKAEAAKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYU9</accession>
    <name>A0A1Y2AYU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative low-affinity zinc ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_536936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYU9"/>
    <dbReference type="FunCoup" id="A0A1Y2AYU9">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYU9"/>
    <dbReference type="InParanoid" id="A0A1Y2AYU9"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY27748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="369" mass="39188" checksum="AF9E584958704FAB" modified="2017-08-30" version="1">MAQVGQDECSISNSDSHFHLRIGAIFIILVTSLIGAIAPILLRQSSFVPKAVFDFAKFFGSGVIIATAFIHLLAPAWDELTSSCLSGAWTEYPWAPAIVMASVYGIFLAEVAAYRIGSEKLDRLGVAYSSHNDDATDAHAHSHHHDPPTSIDTSGPVHLHHGHPSHPHLFSEPSSSIPITQNADPEKNLDASTDDESTINQLPSRSEASAQLVAVAVLEFGVVLHSVIIGLTLGTTDDFTTLFIVIVFHQMFEGLGLGSRLAGLELPGQFTVWRYAAAVGYSICTPVGLAIGIGARESYNGNGAAANIVSGVLDATSAGVLLYTGLVELMAHEIVLNPRMMRASSGKLTYVLCCMLLGSGLMALLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B040</accession>
    <name>A0A1Y2B040_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_535913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B040"/>
    <dbReference type="STRING" id="71784.A0A1Y2B040"/>
    <dbReference type="InParanoid" id="A0A1Y2B040"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="856" mass="95182" checksum="51517C8965CDD171" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0A3</accession>
    <name>A0A1Y2B0A3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome regulatory subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_468655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0A3"/>
    <dbReference type="FunCoup" id="A0A1Y2B0A3">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0A3"/>
    <dbReference type="InParanoid" id="A0A1Y2B0A3"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="17"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="38343" checksum="A4E6333D9225FF5F" modified="2017-08-30" version="1">MPGLTTAQVNELSGINVVIHPLVLLSVVDHAARVPISRNKRVLGVLLGQDNGTSINVANSFAVPFEEDERDPRTFFLDLDFVEEMWRMFRKVNARERPIGFYHTGPRLRSSDLEITELFKRFCARPVMVIVDVRASGGRGDTGIPTDAYFAVEEIRDDGTATQRTFTHVPTSIEAEEAEEIGVEHLLRDIASSSGAPSSTLLTTQSLSTRVAAQLNALQGLRARLDEISEYLSAVRRSTLPINHQVVYQLQEIIGLLPQIGGDADLGKAFRVETNDSTMVVYLSAIVRTVLALNDLIENRIENVQQEIEDAKSPEEKIADAAAAAAGVTAKDVEKAKKENQEEKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B177</accession>
    <name>A0A1Y2B177_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_534877</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B177"/>
    <dbReference type="FunCoup" id="A0A1Y2B177">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B177"/>
    <dbReference type="InParanoid" id="A0A1Y2B177"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="74"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="590"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY28486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="778" mass="83865" checksum="45111A03CF5582E3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1A7</accession>
    <name>A0A1Y2B1A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_534271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1A7"/>
    <dbReference type="FunCoup" id="A0A1Y2B1A7">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1A7"/>
    <dbReference type="InParanoid" id="A0A1Y2B1A7"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="92" mass="10456" checksum="EB41BEC3E66D099C" modified="2017-08-30" version="1">MVKGTPSFGLRHSKSHTLCRRCGERSFHKQKHTCAQCGYPSAKIRSYNWGLKAKRRKTTGTGRMSHLKSVDRRFKNGFREGTSAQKKAKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1S2</accession>
    <name>A0A1Y2B1S2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BCR39DRAFT_467925</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1S2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1S2"/>
    <dbReference type="InParanoid" id="A0A1Y2B1S2"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012146765" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="19"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="177"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ORY28788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="497" mass="50938" checksum="0B294550DB6945F1" modified="2017-08-30" version="1">MSFARSLIIFSILAGALAQDSSVNPATVTQAVASTTAAAASISIDTSLPQTPLVSAVDGYTIPALSELTSGAPTAADATLASTPTAGATVTYVSGAPPIPTAALVIANYPALDQVPPTNSSEVQAWISAIDWTKVPSYNATDGTCSGTPGAITDGRCWWTCGQCTRDTDITVCPDQYTWGTSFDDGPSPYTPALLDYLNEQSIKTTWFVVGSRVLSRPEMVQAEYASGHQLSVHTWSHPALTTLSNEEIVAELGWTKKVIYDTIGVTPNTMRPPYGDIDDRVRAICAQMGLTPILWTGIEVNNTDTNFDTTDWNIPGGKATGESALGKFEEILNTYVPMLDTGFIVLAHDLYQQTVDLAVGYVLPMAIQSGKFKLTSIIDCLGRPLSEAYIETSSNATQTLITSASTTYFQASVGGAGTAAVLPTSATSSGAASGSAGTSASGSSASGAGVSVSASRSAASSAASTGAASRGAAVSLGTGVGLMALAAVAFGTTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2U3</accession>
    <name>A0A1Y2B2U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metallo-dependent phosphatase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_532806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2U3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2U3"/>
    <dbReference type="InParanoid" id="A0A1Y2B2U3"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="114"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="5">
        <location>
            <begin position="409"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="680"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="680"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="90244" checksum="695C8598EEF7BA9C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2U9</accession>
    <name>A0A1Y2B2U9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_532984</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2U9"/>
    <dbReference type="FunCoup" id="A0A1Y2B2U9">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2U9"/>
    <dbReference type="InParanoid" id="A0A1Y2B2U9"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="526"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="347"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="347"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY29158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="656" mass="72367" checksum="062DCEAD5BDCC8A6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B381</accession>
    <name>A0A1Y2B381_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_533572</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B381"/>
    <dbReference type="FunCoup" id="A0A1Y2B381">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B381"/>
    <dbReference type="InParanoid" id="A0A1Y2B381"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000024">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="328"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="405"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY29010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="533" mass="56752" checksum="CD3382D8F9C878B1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3A3</accession>
    <name>A0A1Y2B3A3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_532222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3A3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3A3"/>
    <dbReference type="InParanoid" id="A0A1Y2B3A3"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="272"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="488" mass="52382" checksum="0DCB7430263D8415" modified="2017-08-30" version="1">MGLASKLAAAQGGAPAGGAQPNQYAGNPPPPSGAQSYGQQPPAQGQQQGQYGQSQGYGQQQPPSVPGRTQSAQYGAQSGAPPLSASGYGQQQQSQQYPPPPGRPLPSQGQSQYGQPQQQGQYGQPPQQGQYGQPPQQGQYGQPQQGQYGQPQQGQYGQPQQGQYGQQGQGQYGQQPGGLPSQQYGNQPPQYRPAQGAAPIPAGGGGSDNPQVLLSLLQQCVQDQNIQAFYPPGSLDMIAAKVASSGALDKIATEWRMPKELASDLVKLSLFDVVLYVDDSGSMAFEEGGERIDDLKLIMSRVAYATSLFDQDGIQVRFMNNRLEGNNITSEPQALQLVQQVKFSGLTPLGTGMWTKILQPLVIGPARSNQLQKPVLIITITDGTPAGESKDEIFNVILRTDQELRRTRYGPDAVSYQFAQVGNDLKATKFLEDLDNHPQVGGLVDCTSNFEVEQAEMSRKSGIDLSPEMWLVKLLMGPIDTSYDTKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3E9</accession>
    <name>A0A1Y2B3E9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_532509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3E9"/>
    <dbReference type="InParanoid" id="A0A1Y2B3E9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="65" mass="7552" checksum="254DAB4B0CCA2093" modified="2017-08-30" version="1">MRIAVATLIDASLIGIIYTVYSIYIFLLRIFPHGPSHRLLHGRLPVVLLERFGYRHVIHLQRPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3F3</accession>
    <name>A0A1Y2B3F3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_505800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3F3"/>
    <dbReference type="FunCoup" id="A0A1Y2B3F3">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3F3"/>
    <dbReference type="InParanoid" id="A0A1Y2B3F3"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY28615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="154" mass="17648" checksum="A98AB819FADA48CA" modified="2017-08-30" version="1">MFRVGLRPATTAARILGRRSASTAVSAEEQLSIGSLGTRHGVELLQVELPKKLPDNDYNERKKNVYEHALHTTELWRRISFYVCLPAVVVCAIYVYKLEKAHEEHHKHLIEANGGVEPERKTYSYMNIRTKPYPWGNKSLFFNPKTNIPVEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4C6</accession>
    <name>A0A1Y2B4C6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HCO3 transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_167758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4C6"/>
    <dbReference type="FunCoup" id="A0A1Y2B4C6">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4C6"/>
    <dbReference type="InParanoid" id="A0A1Y2B4C6"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="74"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="497"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY29678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="673" mass="74500" checksum="D6DFB20D9E0A8EB4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4K7</accession>
    <name>A0A1Y2B4K7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_588145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4K7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4K7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4K7"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34990" checksum="0F9CEFD758EE03E2" modified="2017-08-30" version="1">MSLVTLPADADFAEIREVIDRDGGIIISNFASEELMDQMNDAIDPYFDAVVASGVMDEYVRDGVNFFPKNNVHVYGTFGKAPEVASKLLETPVHKQIMDHYLNDEYKFVVGEDIHSHNSGWGLLLTNAMRVSPGSIPQQLHRDQVVHCVPQTPFSGYATQMGCLIAGSDSTEANGATRVVPGSHKWEWDRRPKPEESVPAAMKKGSALFWLGQTVHGSGQNHMEPGSPNSVRKLYGMFGVRDYLRQEENLFLASPWETVKDCSTYALTKLGYVKTASGVGMVDLGHPLRWFKPLAHYRQQAGYDDSDIPENVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4N5</accession>
    <name>A0A1Y2B4N5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4N5"/>
    <dbReference type="InParanoid" id="A0A1Y2B4N5"/>
    <dbReference type="OrthoDB" id="2586466at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="643" mass="71022" checksum="CE2F9B2B2EE7A9C2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B584</accession>
    <name>A0A1Y2B584_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_530466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B584"/>
    <dbReference type="STRING" id="71784.A0A1Y2B584"/>
    <dbReference type="InParanoid" id="A0A1Y2B584"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="268"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY29991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="600" mass="64882" checksum="B43D09A96FB917D0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B586</accession>
    <name>A0A1Y2B586_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_531431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B586"/>
    <dbReference type="FunCoup" id="A0A1Y2B586">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B586"/>
    <dbReference type="InParanoid" id="A0A1Y2B586"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY29647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="370" mass="41781" checksum="0173C60CF2AB2C58" modified="2017-08-30" version="1">MSTTARKKVLLMGKSGSGKTSMRSVIFSNYSARDTKRLGATIDVEQSAVRFLGSLVLNLWDCGGQNNFVDNYLTAQKDTIFANVAVLIYVFDITSTEWEEDLRYFEDILTALRENSADAGVWILVNKMDLLDKEDPKRTRYEERRADVIRVDERIAQKSLGDGEDRGRLRCFPTSIWDESLYKAWSSVIHTLIPNIGLITSHLTYLRDVCLAVEAVVFEAETFLVIAKSGSPLDSPPSEFDKQENRGGASVLDPQRFEKISEIIKGFRKTCQRTGEQFLGFESKFDECTVVLEPMTRNTFILIVSVDPRVETALMQYNIVNAQIHLSEFAGKIVLDRKCGLCRNNKELRYDAPGDLDPSVRAWDDPGPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5T7</accession>
    <name>A0A1Y2B5T7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_587991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5T7"/>
    <dbReference type="InParanoid" id="A0A1Y2B5T7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="211" mass="23931" checksum="66AD27CE93F9D44A" modified="2017-08-30" version="1">MMTQESFLDMLDSFLDITAPSSPTVTSPSVPATGDSSNRPPAGQSTDTRGSDLYEGKWYYVSSTDVRAKTAQTVSRWETKLDQAKSNPPTSENEAMTVHSEMSEIFRLRRSEEDTHEDVTLKSLTYYFVSKADAILSDRLLPEDSRKLIQKARDTLMKAPSIFNQLTGRSTLRSRVDAAFTIWRKPNPTARNFRDELHDDSLKKTRRLFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6D5</accession>
    <name>A0A1Y2B6D5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_155502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6D5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6D5"/>
    <dbReference type="InParanoid" id="A0A1Y2B6D5"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="156"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY30246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="387" mass="43286" checksum="59F03E771E9FE7A7" modified="2017-08-30" version="1">MTFPYYRRASSLHGDTSKLMRCCVDRIMVHIDKVFWIGSGFECDLEIDSPYVSDKHIRLAGVQTPGRLALAVMLVTGRSGVILNDVRYRPNQPFKYEGREVATRGLILRDGDIVKLPHTPAVFTYHHNQDIYDQEDPKSDQSTQEPSHAVQIGKWQISNFVLGTGTFGTVNLAWHCDSRVQVACKTIHVRTEAKEIMDLEIKILRQLNHPGVISLLDTNAEGEGRNQVLHVILELSTGGELWQWVISNSDIGLTEMEIKWFAWQLVSALQYIHSNGVAHRDLKPENILLEFAGLYPRLSVADFGTAMTLSHYTDTLSRHSSAEVIDTVGTPQYFSPEKLTACLACTKEDTDDSASPAKGDRANKKITADQAGDCWALGCKEFLRQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6S7</accession>
    <name>A0A1Y2B6S7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_587815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6S7"/>
    <dbReference type="InParanoid" id="A0A1Y2B6S7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="123" mass="13192" checksum="F58960DFBF62B69D" modified="2017-08-30" version="1">MRNKVLGGGGGGGGGGGGGDGILGIWDTGAPLDDDEDDGDENEDADEDEEDEEDDADADDDEDGTDDDEDEDEDEDEEDDGDENEDADDDEDEDDEVDDLQMPSNNVERKSKADNRECSHLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6U0</accession>
    <name>A0A1Y2B6U0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_531167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6U0"/>
    <dbReference type="InParanoid" id="A0A1Y2B6U0"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="54"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY29825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="525" mass="59832" checksum="B0F1E6B5776EB336" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B784</accession>
    <name>A0A1Y2B784_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_152313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B784"/>
    <dbReference type="STRING" id="71784.A0A1Y2B784"/>
    <dbReference type="InParanoid" id="A0A1Y2B784"/>
    <dbReference type="OrthoDB" id="2564952at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="657" mass="71204" checksum="38C2D0B8684913C7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7Q3</accession>
    <name>A0A1Y2B7Q3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase family T4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_528159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7Q3"/>
    <dbReference type="InParanoid" id="A0A1Y2B7Q3"/>
    <dbReference type="OrthoDB" id="2107894at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000004">
        <property type="entry name" value="Beta-peptidyl aminopeptidase BapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512:SF3">
        <property type="entry name" value="BLR5678 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="D-AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="407" mass="43269" checksum="B71E30877D464497" modified="2017-08-30" version="1">MSAQVSSPHSTSRRRLRDLVPSLQLGRYLPGPLNGITDVSGVLVHTESIRKSNGIDGETGRKVHAVNTGVTVILPRKEWFREGCYAGMFRFNGSGEMTGSHWLAETGLLHSPIVLTNSFAVGPCYTGIYEYAIREYVAPGKTAGFFLLPVVGETYDGHLNDIAALSVTSDMTIRGIAQASKAAVPEGNTGGGTGMMCSGFKAGTGTASRIVNGTKRGEGGQEEKVEFTVGALVQTNFGKKDDLTVCGIPIGRLHNESRLPAPVPTQPPHKEGSIIVVIATSAPLHPLQLQRLAKRATVGVARLGGWGGNTSGDIFLAFSTGAAIPRESDRSIWSSTTGQGSPVVFDTTINSIFEAAADVVEEAIYNSLCMAESMEGPEGRKAEAIELDWLKETMERHHVDAPYTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7Z1</accession>
    <name>A0A1Y2B7Z1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_528486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7Z1"/>
    <dbReference type="InParanoid" id="A0A1Y2B7Z1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013254406" evidence="2">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="195" mass="21785" checksum="966792C461789657" modified="2017-08-30" version="1">MRTSTLLTAVAIWGSTVGLTEANTPGSDAPTRRTYLSYCKDEVWQAHVDSSRHVLYQTPMTEKEWRRGNRAVGCSARFVSQGERPTQESNHDTEEGDDTPEERTQRCKDLVWDSALRRHLETPSLTDPQSLANAEAHLKTLECVDEYVRDMKGSQASEVSDVDSYFVSRPPSAVPTLGSPKATLSPSVSWNRQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B854</accession>
    <name>A0A1Y2B854_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_527805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B854"/>
    <dbReference type="FunCoup" id="A0A1Y2B854">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B854"/>
    <dbReference type="InParanoid" id="A0A1Y2B854"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012440656" evidence="9">
        <location>
            <begin position="22"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="30"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="162"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="389"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY31018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="637" mass="71370" checksum="8DFB1405B5E3A32F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA80</accession>
    <name>A0A1Y2BA80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_526181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA80"/>
    <dbReference type="STRING" id="71784.A0A1Y2BA80"/>
    <dbReference type="InParanoid" id="A0A1Y2BA80"/>
    <dbReference type="OrthoDB" id="2565097at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="596"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="71607" checksum="943AC4C0F9EC5F11" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAW7</accession>
    <name>A0A1Y2BAW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_524764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAW7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAW7"/>
    <dbReference type="InParanoid" id="A0A1Y2BAW7"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="202" mass="22418" checksum="1CBFCD0577A2E2E5" modified="2017-08-30" version="1">MPEPQFFETITKSYVDVPITEAGVDTAAFCEASENLVKIFGLFGNPAFTVVQNDLTGNIGKVRAYLAANPESAQTLESLLAHDKASHPNPKDRTTSSGLMWLLRGLKFTALGLRINLSNPNEEFSASFTKGYEQSLKKFHGMMVRPIFYLAMKACPYRATFYDKLGHPTEVVMPKLEEWLAALEEIIKKEEGVFKAGGYGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBE2</accession>
    <name>A0A1Y2BBE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_524347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBE2"/>
    <dbReference type="InParanoid" id="A0A1Y2BBE2"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="123" mass="13677" checksum="E1B30552FBA0EAE1" modified="2017-08-30" version="1">MSSVPPPQPQADPHSLSHAAHLQQATKNVNRFAKRDPALYPLSFIVVGALGVAGYFFMSKTTEVEPHKKLVRDGIVHPWDDASKHDTHPSQLAAFKYRYKTRQGHFEDADPAMGAPETFNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBF7</accession>
    <name>A0A1Y2BBF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_524402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBF7"/>
    <dbReference type="FunCoup" id="A0A1Y2BBF7">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBF7"/>
    <dbReference type="InParanoid" id="A0A1Y2BBF7"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="451" mass="50263" checksum="EFE8718C0B78251F" modified="2017-08-30" version="1">MDEEYDVIVLGTGLTECILSGLLSVDGQKVLHMDRNDYYGGDSASLNLTQLYQKFRGTPPPESLQLGRDRDYAVDLIPKFILSSGELTRMLVHTDVVRYLEFKVVAGSYVYRDGRISKVPSTEMEAVRSPLMGLFEKRRARNFFQYLQNWKEADPATHQGLDINKCSMKDVYTKFGLEAGTQDFIGHAMALWLDDDYITKPARPTIDRIILYTQSMARYGKSPYIYPLYGLGELPQAFARLSAIYGGTYMLDKQIESVNVDENGVFTGVTSGGETVRAKKVIGDPSYFGAGKDLESGGKVRVIEIGKVIRAICILKHPIPGTDDSDSAQIIIPQNQVGRRNDIYIATVSSAHNVAAQNVWIAMVSTIVETSVPEREILPGLQLLGNVVDKFVSITPLYAPTSPGTDENIFITKSYDATSHFETVVEEVFDVWQRVKGEKLVLKKREVELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBL2</accession>
    <name>A0A1Y2BBL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBL2"/>
    <dbReference type="InParanoid" id="A0A1Y2BBL2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="232" mass="25757" checksum="2A9E63CDECE126A0" modified="2017-08-30" version="1">MSSSTINSGTNNSRTSDISSLPTGSRSTTIDNTNINGHHFEESDPNGPVKTHVYRDEFLDSLNTAVSKTKGFVQLVVSRTDYEMTSESSIPLRSRLWKLSLHTHAMTESEDPSTLVVTQEISTVLKRERESGQDCFWDFPWDKGIDHETNNLIKLLETGVKCSRDPGLSSYAKSSYGTLSTVPFGNFTEVLRWTDGGSESFSIISILVSQTAPGENLPRSDVLNKYTMVPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBQ9</accession>
    <name>A0A1Y2BBQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_44564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBQ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBQ9"/>
    <dbReference type="InParanoid" id="A0A1Y2BBQ9"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="268" mass="29025" checksum="21A64E7F96257671" modified="2017-08-30" version="1">MSVMKNNLYLKNALTGKDKAPGIGFWLTFPGPSLIRTIISTGGFNWVLIDAEHGQISDKDYYELNNAAAQFGVSPIIRVPNAEEHLIKRALDSGAHGVMTPMCHTVEDAQKIVKWNKYPPFGSRGYGPMFSPHSFLAPEAQYAQEADEHCLVIVQIESRQGVENVEEIAKVPGLDVLFIGPFDLSKFMNVQFGSEEHEAAIQKVLKAAKSAGKTAAIFCTSGEQAKMRLDQGFDMVSICTDIGAVANEFQKQLAAAKGVAAGAAKSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBR4</accession>
    <name>A0A1Y2BBR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_492824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBR4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBR4"/>
    <dbReference type="InParanoid" id="A0A1Y2BBR4"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="695" mass="77418" checksum="E973C056445836C1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCE5</accession>
    <name>A0A1Y2BCE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_522591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCE5"/>
    <dbReference type="InParanoid" id="A0A1Y2BCE5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="107" mass="11783" checksum="8AE4380FA04D6269" modified="2017-08-30" version="1">MADHSDQSALMSKFKRSTDTNPEESVTGTTQPSGNDKSPFVFFTLICVVVFVFVGSMISLSVKEGAQVKASKTAMQDATLALPDKLDLLTTELRLLRQAVERMEQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD35</accession>
    <name>A0A1Y2BD35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">BCR39DRAFT_379690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD35"/>
    <dbReference type="FunCoup" id="A0A1Y2BD35">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BD35"/>
    <dbReference type="InParanoid" id="A0A1Y2BD35"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY32616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="84" mass="9145" checksum="E56D05736B46708F" modified="2017-08-30" version="1">MASTILPLELVDRCIGSSIWVLMKNEREFVGTLMGFDDYVNMVLKDVKEYAVTPEGISETELGQTLLNGNNIAMLIPGGKGPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDX4</accession>
    <name>A0A1Y2BDX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_564013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDX4"/>
    <dbReference type="FunCoup" id="A0A1Y2BDX4">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDX4"/>
    <dbReference type="InParanoid" id="A0A1Y2BDX4"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000077">
        <property type="entry name" value="GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="23"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="425"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="636" mass="69552" checksum="7717461C7F866093" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDY2</accession>
    <name>A0A1Y2BDY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_520833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDY2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDY2"/>
    <dbReference type="InParanoid" id="A0A1Y2BDY2"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="246"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="98724" checksum="55F47386DE89810F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEM1</accession>
    <name>A0A1Y2BEM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_504111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEM1"/>
    <dbReference type="InParanoid" id="A0A1Y2BEM1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="209" mass="23064" checksum="17C54334AE1A87EE" modified="2017-08-30" version="1">MDSTNTNGRPGRVSSDGNNEPIAGWQDEMTVATSDGSLAPESRGRDEHSTGIGRDTTGEIDATGSNIQSAFNFATGERHFRWWTRTESSGQIGEVPVIHDTSDSWYVAPGNPVRMYHTKITFTGFPAMISMVDGTIFDETIVDRTDTQWFVFPSLDNQPSLFIAFTRKHPPVTHIRTLTTRTEATDTQMTDTQPRPATDSDATSNSRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BET6</accession>
    <name>A0A1Y2BET6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_519378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BET6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BET6"/>
    <dbReference type="InParanoid" id="A0A1Y2BET6"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="117" mass="12728" checksum="C7571C6F8FE72B94" modified="2017-08-30" version="1">MSEANSGAIDPTTGSSGHPQTGEPFEHAPEDSHLRLDGKDGRTHANTVADAKRTEAIEKAVEEKKAELQHDPTLLAKSHGNEPSRGAVKDKELVEDDDETIRKMDEAKKQSAEAHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF75</accession>
    <name>A0A1Y2BF75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SART-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_478095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF75"/>
    <dbReference type="FunCoup" id="A0A1Y2BF75">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF75"/>
    <dbReference type="InParanoid" id="A0A1Y2BF75"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="700" mass="78466" checksum="6EF76ADC324458E2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG72</accession>
    <name>A0A1Y2BG72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG72"/>
    <dbReference type="InParanoid" id="A0A1Y2BG72"/>
    <dbReference type="OrthoDB" id="2564882at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="476" mass="53673" checksum="3AB928BD5539BEC5" modified="2017-08-30" version="1">MGSSAYGPPPPGSMQIAESIAAGSLYGTESQMDFGPSPSSAYGEGFHTSQHRGLPGTNPYPDSPIPRGIGLLQHADGRSLHHHSYANQSHEQHDRPTHTNHHHHQQQPLRQYPLERERCKKDELDELDDRGSDASYYARRPKLYRSRSGSALSSSSESSDGRMSVLSQRRSATLPQHRQSHGQSHRSPSFGQAHSPITPSPLSLASRVPVPERKGHQTSSSVDARENHTRERRRRLSVDVLPDERRRQRRLSVDAAEDGDIKARHRFSSMNGRQEDDKRSRNGEANYYEEVRQGHQYQEQQQPPEHHRQDHYPPPPPSSHLLSPPSPYRSLTSPTRHRHRSTSEIPFPTARFPSPTPSSRYLAVPNESLSQLRITIPRRRAVTMNHEQQQQQHHRSPRSPSHYEPRSAQPMMGYAGSEGGDGFNDGASMAASHMTFMDGSMGGRTSQYGLPKYPHIVKPDYRRFCVQRGTADVFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGB1</accession>
    <name>A0A1Y2BGB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_491531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGB1"/>
    <dbReference type="InParanoid" id="A0A1Y2BGB1"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="480" mass="52404" checksum="84930F38A5585A83" modified="2017-08-30" version="1">MSEQERIVDGEQADYGAIRSTSGSSTAAETDVGDVKAQPTPLDMAQIVLLSFARISEPLTFTILFPFVQQMIVDTGEVAIEDVGYSVGLIEVSFSITQSLSLLYWSRAADKYGRKPVLLASLFGAFVATVLFGFSKHVWQMYACRFLAGVFGGNAMVIRTLFTENSDRTNQAKAFAYFAFAANIGGLVGPTIGGFLSQPVKQWPRLFGRWQIFIDYPYCLPCLVAGLYIFFTLILSAVYLRETRPDECDNPIPIRQVLNKKILRMFGIFGWTVAVAFSLGAAFPLYLFTPVKIGGQGMTPPQIAQIQAAAGLSQGIWLLFAMPRLDTKLGTKRLFICISSFYPLVMIIPILANTFSRRSNPAGSWTLIALYVFVGQACQMTFTSVQLLLNACSPPSAIATVNGIAVAICGIVKSIFPAAINALFALSVSRQILGGYLSWIVMAFLAAGVFVISFFAPEDRHESDDVQKGRVMESEAEALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHH4</accession>
    <name>A0A1Y2BHH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_503559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHH4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHH4"/>
    <dbReference type="InParanoid" id="A0A1Y2BHH4"/>
    <dbReference type="OrthoDB" id="2575061at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="868" mass="94777" checksum="DCA85CE4A23BB5EC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHU0</accession>
    <name>A0A1Y2BHU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-trefoil DNA-binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_518513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHU0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHU0"/>
    <dbReference type="InParanoid" id="A0A1Y2BHU0"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="121"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="403"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="855"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1040" mass="112187" checksum="AEFBE99BCEE80686" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI25</accession>
    <name>A0A1Y2BI25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_445114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI25"/>
    <dbReference type="STRING" id="71784.A0A1Y2BI25"/>
    <dbReference type="InParanoid" id="A0A1Y2BI25"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="171"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="595" mass="63722" checksum="5571B25C2D272982" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIT2</accession>
    <name>A0A1Y2BIT2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_514035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIT2"/>
    <dbReference type="InParanoid" id="A0A1Y2BIT2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="194" mass="21040" checksum="858DFC2086BBDE60" modified="2017-08-30" version="1">MANPSTPTSRPLSLTDTLNGFRFVPSSHAQLQSAWGELRARCDKPSESVTVDDTLIQTMPFGPSMPGDITTLGGDSLPVAAQLSLELRVVPTSHAEYTLQNLRVPLGATNKPAETRVTCTTRLQSHCLPRCPPPPSLTATLQPTPDHSYQSRVLVNIWGGDDAACKLNSRHPRRRAWAGGHFVQKIAVLTVTCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIW3</accession>
    <name>A0A1Y2BIW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallopeptidase family M24-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_476380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIW3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIW3"/>
    <dbReference type="InParanoid" id="A0A1Y2BIW3"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="569" mass="62731" checksum="181C8303EB2513BA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ47</accession>
    <name>A0A1Y2BJ47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_514750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ47"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ47">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ47"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ47"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="511" mass="55435" checksum="E6E8E0BFA462A55A" modified="2017-08-30" version="1">MPIDDRNEGRSEANSESAPLNQVKNPPIGVKWRSSTWYITLVVAAGTTTDALTYNIVVPVLPYRLEALGYSNISSLTSWLFFSYSMGIFLATFPVAYFFHKYPYRRVPLIVGVLLLEVSLVLFMAIRPYWVMVVTRFMQGACSTVVWTVGFALICENVEEKNMGRQIGFAVSGVSIGTTIAPPIGGALYQHLGWYSPFIFCIIVLFFDLVGRILVIEQKDLPLYGIERGAPTINEISQREPDSDPQASPAKDLIPLGPISGAATTSATASNIHEEKSPPSKALSPWGVLKVLAKQPRGVTGICVSFAIGILLGALDPTLTLRIETVWNKDSAFVGLVYLAATAPTFICAPITGHLADKYGSQWVMAPCLFFVLPWLPLLLLTNSLAGFIVYFAIANTMGSCAFGPVGLELAMAARGAEGISEIHQFAAMNLAFSISTAIGSIVAGQMYDHLKYGWGATMWFCFGFTAVSSIVPFCLGGSPTLLQIVLRRHRANKIKEDRVPAEGSVATEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ74</accession>
    <name>A0A1Y2BJ74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_556329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ74"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ74">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ74"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ74"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="7"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="255"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="292"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="37495" checksum="2013598A41D70762" modified="2017-08-30" version="1">MTLTPRCLVRGSINIDEFFSVDHIVLAGETISSTSFTRKAGGKGANQAFAVAKACGIPGSVVLDGAVGVDGVWVRELLYREGVDVARVRVLEDQPTGRAIIQSAVDGENSIVLYKGANYDLPPTDTYTDTSPSLSGFTHLLLQNEIPLSSTLSYLDSASQINGFTTIFNPSPMLSQDELRAFPWNKLGWLIVNEGELESLLVAFGIDQHQQQRKRQTEGKKNVGEEGDEIEERAKGRLNSLRRSKGCETLNVICTLGAKGILYSTTSKAENEIGYLAAAPLKGPVVDTTGAGDCFAGYFAAGLMQRRQDEPLDNILKTCLTACAMCVEKAGAMESYATKDQVIARLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJA8</accession>
    <name>A0A1Y2BJA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_515169</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJA8"/>
    <dbReference type="FunCoup" id="A0A1Y2BJA8">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJA8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJA8"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF9">
        <property type="entry name" value="GLUCOAMYLASE, INTRACELLULAR SPORULATION-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="12">
        <location>
            <begin position="86"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="520" mass="57926" checksum="CB08383185A3BC8C" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJB4</accession>
    <name>A0A1Y2BJB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Or S-antigen, C-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_515253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJB4"/>
    <dbReference type="FunCoup" id="A0A1Y2BJB4">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJB4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJB4"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="748"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1125" mass="122359" checksum="CE3D20B46344C908" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJI4</accession>
    <name>A0A1Y2BJI4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_515722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJI4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJI4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJI4"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="205" mass="22527" checksum="5406B46800701127" modified="2017-08-30" version="1">MPRIDPKSTVLLICDVQERFRSAIFGFDAMVGTISKMVKAAQLLEIPVITTEQNPRALGSTIPELGLSSLPPNLDLGTFSKTRFSMTIPSITSILQERSVKWAIIVGIESHVCVLQTALSLLETDTKPYILADGVSSCNRQEIPVALERMRHDGVTITTSESILFQLVDDASSPLFKPFANLIKESKESTKTALSTLLDRQTNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJM4</accession>
    <name>A0A1Y2BJM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJM4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJM4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="303" mass="32684" checksum="E497F381C2338123" modified="2017-08-30" version="1">MSDPSDPTASSPQASSARSSALDPPSTVGPSTTLTPSCRQDSSSYLSRKFSAWRMIPTQIPATTEPLTTEPFFSIRIPSGFRVPRRTGNSSEAPGDALLKVIPKELKDVLQRQTREGARQMIASTLSKILPNCESAVIYVDNGASSETAGWMDLATQTVGRMSSVKQMSLIISSNTSYKFLDSHLGSSVTGNRNMPVDISIPFKDPSDVTKFLTDMTESYTRVIDQQVPVSVYVNKGIWPGDPNSYDITIPGFEGILDPGSWSVKNTSKGLWPVTLVFDPLHIGSEGKPTDTISLVRTSSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJZ3</accession>
    <name>A0A1Y2BJZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_516702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJZ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJZ3"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="431"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="951" mass="103225" checksum="4F007934A1B21813" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKW4</accession>
    <name>A0A1Y2BKW4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_555565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKW4"/>
    <dbReference type="FunCoup" id="A0A1Y2BKW4">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKW4"/>
    <dbReference type="InParanoid" id="A0A1Y2BKW4"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="793" mass="83694" checksum="4801936F122BEE6C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKZ5</accession>
    <name>A0A1Y2BKZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_509791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKZ5"/>
    <dbReference type="InParanoid" id="A0A1Y2BKZ5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012078882" evidence="1">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="85" mass="9711" checksum="C85DB8F1C8FD0583" modified="2017-08-30" version="1">MLLFLLAPLQIFLQLSYLPLRLLHIGSKIVLEFSYISLKVFQICPNVVSLPSKVADPVVLVYLPILHLFELPNQRLDMFLRSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL00</accession>
    <name>A0A1Y2BL00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_7878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL00"/>
    <dbReference type="STRING" id="71784.A0A1Y2BL00"/>
    <dbReference type="InParanoid" id="A0A1Y2BL00"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="401" mass="45332" checksum="1311446E03673F7F" modified="2017-08-30" version="1">MQVDSSLPEAGPSTPRLLEPQDRAIDPVAELKDLLGRETAKTRLRRLAAHRDTQPLFNPICISTTLSACNKVRSDCSRAHFEPIIRPYTDISLGYCSYLNLCYGEPMFRSNPSLGDANAPRGGVKECRYMHFQVAPATTRTSQPLPVEFPAAIPIRAVDKLLGVEATQGDEAWRGVKQWINCDLRSFDYSVLGQFQVIVADPPWDIHMSLPYGTMTDDEMRRLPLAALQPDWALLCLWVTGRAMELGRELFSVWGYRRVDELVWVKVNQLGRLIRTGRTGHWLNHTCEHLLIALKLPASWPRDKPIPYDEIPALRSLGRGVDTDVVVAEVRETSRKPDEVYGVIERLVPRGRKLELFGRKHNARPGWLTLGNQLGDSQIAEADLHDRLQQRYPNQPFALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL31</accession>
    <name>A0A1Y2BL31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sterol 3beta-glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_461494</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL31"/>
    <dbReference type="STRING" id="71784.A0A1Y2BL31"/>
    <dbReference type="InParanoid" id="A0A1Y2BL31"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF26">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="9">
        <location>
            <begin position="758"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1189" mass="131814" checksum="BA4D5FA697B29516" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL33</accession>
    <name>A0A1Y2BL33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_510019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL33"/>
    <dbReference type="STRING" id="71784.A0A1Y2BL33"/>
    <dbReference type="InParanoid" id="A0A1Y2BL33"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="213"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="603" mass="66908" checksum="8582C9B5AC7A8D8C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL52</accession>
    <name>A0A1Y2BL52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_514936</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL52"/>
    <dbReference type="FunCoup" id="A0A1Y2BL52">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL52"/>
    <dbReference type="InParanoid" id="A0A1Y2BL52"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="224"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="413"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="650"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="785" mass="86395" checksum="B785A7398308A0E8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLC5</accession>
    <name>A0A1Y2BLC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_510859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLC5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLC5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLC5"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="54"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="44119" checksum="D77F969BE007FF45" modified="2017-08-30" version="1">MAPRILEKSSSEYKPVGPNERVSPLELFSLPPKPRSELEVYRILGPRAGVRVSPLCLGAMSIGDQWTGYMGTGLSGEKAFEFLDTFYEAGGNFIDTSNNYQDEQSEMIIGEWMEKRGIRDQIVLATKYTTCPVDRATGRFKGLSVNYGGNHGKSLKISVQESLKKLKTDYIDLLYVHWWDYGTSVQEVMENLNVLVKSGKVLYLGISDTPAWIVAQANQWANDHGLTPFSVYQGRWSLGDRAIERDIIPMCRSLGLSLAPYGVLGQGKFKTPQELEKRSLRGGAKPTEEQIKLSKALQEVAEEIGNGATLTGVALAWARQNMTYCFPILGGTNIDHLKANIAALDIELSPEQLAKLSAAGPVDLGFPYDHFGTDPHYNPGGQPNSFIMNTVANFKFVKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLI0</accession>
    <name>A0A1Y2BLI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cryptochrome DASH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_460908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May have a photoreceptor function.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
        <text evidence="7">Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLI0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLI0"/>
    <dbReference type="InParanoid" id="A0A1Y2BLI0"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014133">
        <property type="entry name" value="Cry_DASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02765">
        <property type="entry name" value="crypto_DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF22">
        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="490"/>
            <end position="492"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="577" mass="65292" checksum="4EF7A22D845D1BAF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLS4</accession>
    <name>A0A1Y2BLS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_511743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLS4"/>
    <dbReference type="FunCoup" id="A0A1Y2BLS4">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLS4"/>
    <dbReference type="InParanoid" id="A0A1Y2BLS4"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000028">
        <property type="entry name" value="Replication factor C subunit 2/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="59"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="38604" checksum="3CB54B662806925C" modified="2017-08-30" version="1">MSSSSTSKMPAPAPVTAKHTDAEGYEMPWVEKYRPILLSDIVGNSDTVDRLKVIAEDGNVPHIIISGMPGIGKTTSIHCLAHALLGDAYKEGVLELNASDERGIDVVRNKIKSFAQRKVTLPAGRHKIIILDEADSMTAGAQQALRRTMEIYSNTTRFALACNMSNKIIEPIQSRCAILRYSKLKDAEVLKRLKEICEAEDVKYNDEGLAALIFTAEGDMRQAINNLQSTWSGFGFVSQDNVFKICDQPHPIVVRSMLKSCQKADVDDALARIDGLWEQGYSAVDIVTTVFRVVKGMEELPEYLKLEFIREIGWTHMRILEGVGTLVQLGAMIARLCRLSIPPENLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLU8</accession>
    <name>A0A1Y2BLU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_511847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLU8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLU8"/>
    <dbReference type="InParanoid" id="A0A1Y2BLU8"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="894"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="844"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1243" mass="138184" checksum="E19D3073CEAAF454" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLU9</accession>
    <name>A0A1Y2BLU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_511775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLU9"/>
    <dbReference type="InParanoid" id="A0A1Y2BLU9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="176" mass="20927" checksum="BF485CD99421E555" modified="2017-08-30" version="1">MSHEGQDDISFQISRTKRRSKTTTTTKKKKKKTMADDHPPRRNNYTYFQRPRRQRSIESCDYDCEERNNNHNHDHDDNHNQNGNHIISRSRDKETQTNPRIIEFDFSWAKIWVPGQQASKMPKDSRKENLIDVRAIKEVEMVKTKTWYQMKGLFEVADKEEESLQRRTPVAGYTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLZ0</accession>
    <name>A0A1Y2BLZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_512179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLZ0"/>
    <dbReference type="FunCoup" id="A0A1Y2BLZ0">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLZ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BLZ0"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="198" mass="22417" checksum="7EFD732442933A61" modified="2017-08-30" version="1">MSYQSKILRTANAPLTPPSEIEQQIAQALLDLEQNVPELKSELRQLQISAAKEIDVRGGKKAVVVFVPVPMQKAFHKVQQRLTRELEKKLSDKNIVFLSQRRVLPKPKRNSAAASSQKRPRSRTLTAVHEKLLEDLVYPSEIVGKRTRVGQDGGKLIRVFLDSKDQNLLEYKLDTFSSVYRALAGKEVHFEFPVTATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM11</accession>
    <name>A0A1Y2BM11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_585410</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM11"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM11"/>
    <dbReference type="InParanoid" id="A0A1Y2BM11"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="410"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY35813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="774" mass="82549" checksum="D77147646FB88174" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM13</accession>
    <name>A0A1Y2BM13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">35S primary transcript processing-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_512158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM13"/>
    <dbReference type="FunCoup" id="A0A1Y2BM13">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM13"/>
    <dbReference type="InParanoid" id="A0A1Y2BM13"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="9">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="10">
        <location>
            <begin position="180"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="250" mass="27813" checksum="A0C1D325E718BE6D" modified="2017-08-30" version="1">MPITFQPGTQIKLTNVSIVRMKKGGKRFEIACYKNSVSAFRSHVETDLSEVLQIDQIFTNVSKGQVAKPSEWQKAFNTEDMNKAIEEILHKGDLQINEAERQMNLTSLNREIATLVSEMTVDPTTSRKHTVGMIEKAMTESGYSVRSDKPAKAQALELIKRLIAADEAGEGVLSIRRVRMRVRITMPGKDAKRCKEQVLAEVDEVEEQEMGAEWEAIVQINPAAFRTLTDLVNLETKGKGSVESMGSVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM34</accession>
    <name>A0A1Y2BM34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_35741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM34"/>
    <dbReference type="InParanoid" id="A0A1Y2BM34"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012960191" evidence="3">
        <location>
            <begin position="26"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="387" mass="40968" checksum="728AB3AACDF41DC3" modified="2017-08-30" version="1">MILSSILINLLLLLLLIPRHLTTLATHIDRTTTLDSVSITSLPPSVPTQLPPVPDHFPSNRSRQPEITVVQVHQQVENQAPPSSFVGSIASKQVFPPPYAPLPSPSVIGPSPFLHPLAILLLILIFIGFIATFHPNTLPFNIMPSEAPRASSSSSSASKPKDPRADPRAASSSSSRPSGSSSSSGGGSTSSSSSSPKVEPPNPGPTISANAWMSFFLFCCLVLIILQGPLGLTGGTGVFPTLPGFGMAGGLPGCGGLVATTVPWCAQVAPVQAPAPAPAPIIIQAPQEPCPPAALPQMGGQGNIAGPYGGGGWSWYSNSPQPQPRYYYPRERYDYRQGYGYYAPPRQGYRAVQYQRPGLQVQVAGNPGMLCWYYPYLCNSLINFGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADB2</accession>
    <name>A0A1Y2ADB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_562919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000133">
        <property type="protein sequence ID" value="ORY20511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADB2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADB2"/>
    <dbReference type="InParanoid" id="A0A1Y2ADB2"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY20511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50964" checksum="2BD0D42CC0C5F5AE" modified="2017-08-30" version="1">MSEGSKAVLELPVVLILGGTTTMARPLARYLLAGPCRLAAFVRIADRFSVNPPTTYLDKPFRTLLNDTSVPLEYRQVNLSNVETHKDTLRPPSVWNEEPVNWETFNVIYDLTGDIGFDKPELIQISHTYKLALGLARSAAALPKPPRAYIRLTFCFYEMKSSIGHTESADLRPDGIRGRWWHETLRALGTVHGLNVAVIRCAAWYGYGTWEGQVLPRVVVGHVYQYLNQEMKFLYNSDLRIHTIHTDDIAQGLHLAANYVATTPRETVILQSSVELPFSFQASSGSSTFSLSTKRTSLSDTWKTVDTVVPEKVKVTIPLFNVVDDNDSTQDTLAKAVAGVWGIKYGFINSAIAVLVQQFAKKDFSEMVDDVNENHVEAWSKMLAASDPPIISTPITPFLDEHAFRKMAICLDGSKAKRVLGFKPTRPRVEVDELKRIVKGFQDDGLWCVTACILEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADW5</accession>
    <name>A0A1Y2ADW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase complex subunit H-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_554912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000127">
        <property type="protein sequence ID" value="ORY20711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADW5"/>
    <dbReference type="FunCoup" id="A0A1Y2ADW5">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ADW5"/>
    <dbReference type="InParanoid" id="A0A1Y2ADW5"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="123" mass="13145" checksum="DF1FEFDA52D632C7" modified="2017-08-30" version="1">MASIIRLGARRAAPSLSRSFSVSAASRKDIIQDLYIGQLKSYKPAPQAKDAHTGLVRNYTAPKPPKPPALPTDLAGELSKFDAEEPVIGSTTTSTAAPTEGGESAEEFLTFLEQDLPKDEAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE20</accession>
    <name>A0A1Y2AE20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_77584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000127">
        <property type="protein sequence ID" value="ORY20714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE20"/>
    <dbReference type="STRING" id="71784.A0A1Y2AE20"/>
    <dbReference type="InParanoid" id="A0A1Y2AE20"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY20714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="164" mass="18543" checksum="A7657471C5032E5C" modified="2017-08-30" version="1">MIGPGTGVAPFRGFVQERVALARKAVEKNGPDALADWAPLHLFYGCRKSTEDFLYKDEWPQYAAELRGKFKMHTAFSREMTKPDGSKVYVQDLIWDARAELAPLILEKRAYVYICGDAKSMSKAVEERLMRLLGEAKGGTAEVEGAKELKLLKERNRLMTDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFI6</accession>
    <name>A0A1Y2AFI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_562671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000112">
        <property type="protein sequence ID" value="ORY21368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFI6"/>
    <dbReference type="FunCoup" id="A0A1Y2AFI6">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFI6"/>
    <dbReference type="InParanoid" id="A0A1Y2AFI6"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="265" mass="29425" checksum="790FC1047C186DBE" modified="2017-08-30" version="1">MVQFAKDDHVYSDPPPIPLLAFYIRYPNPFARHVLSVDVLSRTINPTTGRIHTTRLVLKRGILPKWASKWLPVAGASGGRGLDAWVLEDSVVEPPPTDGQGEGEASGSGIGRERDEDRDRNRWPRLRYTQGNLNHRKFMHVVEGGEIFAGPNGTTNHHTTAEIRSDFGGKWSSLIRQRIESYGAGKFEVNAETAKKGMLLIMGLIRARQPLPDTAEFYPPPPPGFSDSWTPSQSSTTNRHEDVQQDSKNFARSRRKDGAGDDEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFW1</accession>
    <name>A0A1Y2AFW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_63351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000111">
        <property type="protein sequence ID" value="ORY21431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFW1"/>
    <dbReference type="FunCoup" id="A0A1Y2AFW1">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFW1"/>
    <dbReference type="InParanoid" id="A0A1Y2AFW1"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="13">
        <location>
            <begin position="93"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="14">
        <location>
            <begin position="234"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY21431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="734" mass="82134" checksum="4580A95ED9D0BA32" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGF5</accession>
    <name>A0A1Y2AGF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_508314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000106">
        <property type="protein sequence ID" value="ORY21688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2AGF5"/>
    <dbReference type="InParanoid" id="A0A1Y2AGF5"/>
    <dbReference type="Proteomes" id="UP000193986">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="275" mass="31457" checksum="1DDD6D87EDF07421" modified="2017-08-30" version="1">MTRKPGKHGGKRVHKKRSPNQSKEPMFAKYKISQWHSTLPVALQLHYNTAKVVNHKQNYDHIAEYLYNQLALHNSKQLQPPPGDFSIAHASPPVGQPKYLIICLWSWYPPQCNTSRKIMKALDECYDSPQTKKDGQNPDFHLNHFGIWAGYSKSIFASAYTMFHQTLAKQTPTNMKKADELLKEAVCGNIRHKVKPLDPETFVRMLGINHKLSQASANNSGPPKHKDLTEHGRLLSIGFNSMVAVPEGPTANWHYDKEDSKEYYTLHMVLSDRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGL7</accession>
    <name>A0A1Y2AGL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Origin recognition complex subunit 5 C-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_554197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGL7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGL7"/>
    <dbReference type="InParanoid" id="A0A1Y2AGL7"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
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        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="5">
        <location>
            <begin position="323"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
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        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="513" mass="56920" checksum="8F46F44EB297888D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH02</accession>
    <name>A0A1Y2AH02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_553549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH02"/>
    <dbReference type="STRING" id="71784.A0A1Y2AH02"/>
    <dbReference type="InParanoid" id="A0A1Y2AH02"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="65641" checksum="774A47974F0B115B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH54</accession>
    <name>A0A1Y2AH54_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000104">
        <property type="protein sequence ID" value="ORY21794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH54"/>
    <dbReference type="InParanoid" id="A0A1Y2AH54"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="259" mass="28202" checksum="CEA569EEA63CF891" modified="2017-08-30" version="1">MSHKYDITSSSPDPEVDLVSLTFRSGHGTFSFGGEASLAPTLALSPSFLSTVALPFDTSERGSTPMDSRFRQDLKSYEDIGSNSTFGEGLTPLTHRSRHESRSFASTEGFNDWGVLNEENESGTGMVVEKARRDQVDESIVPTEGEPSNVLGYVSSRTIPSPQWSLALQDQTFCQNLGDQAKAGLQRNSTMISPSVLSAITSGGSQQPCAACPAVEKVLLASINKVLLKKVRRRRQTDLEDYQEADGQITTHTEHPIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHN0</accession>
    <name>A0A1Y2AHN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_62456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHN0"/>
    <dbReference type="InParanoid" id="A0A1Y2AHN0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012372657" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="33627" checksum="9A8B81B1E821AF76" modified="2017-08-30" version="1">MRRRRPTLTLFLLGALALAQVGSANHGTPLSRRRTARKVEGRQLGADLGFDITGGTVSGDSLLSPILDSIFGGGTSSSPSAGTTSSFTTSNSASSDSSISTESSITTSTTSLAESSSAVVSSDSATTTTITTTTTTSSSLSSSSSPSTSSAAVESTSTSTTESSSIPSTTASSTTVEVSLGTSIADTTSSSVITSSEATSSIQAVTTAVDTEPETSSTSVSTSSSPILPGASISTSSVSLDPSSLTSTSSVSTPTVVSTTSIAASSVVDTPSSSSDVPSSSTPSLSPSPTPSEDTLTTVSASLASPAPTSSSASLTFPVPTASVSDGSSSSSDSFSSCKCRCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI34</accession>
    <name>A0A1Y2AI34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_551908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000096">
        <property type="protein sequence ID" value="ORY22241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI34"/>
    <dbReference type="InParanoid" id="A0A1Y2AI34"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="54" mass="5891" checksum="E21058F47BD2B963" modified="2017-08-30" version="1">MLVSTQLGLSFMTALLSLSYSSGLLVDVICHSASTQRHFLYRLTQLSAVCLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIK9</accession>
    <name>A0A1Y2AIK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_386592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000095">
        <property type="protein sequence ID" value="ORY22324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIK9"/>
    <dbReference type="InParanoid" id="A0A1Y2AIK9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="159" mass="17953" checksum="3AC74D35E6AE3A38" modified="2017-08-30" version="1">MEADQQEPSRLESPQSQRIADFSAQANGSSTASSVLNERFVASVHDTTVDQVLSDPQTLRDQLAMDRAQSRSDLNDLEDKLALRDFELQALQDSNSALQDSCTALRQRVVDAERSERASARVVERWERVMLELVPDRLLGGSRKWRPEEVAEVIRSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIN4</accession>
    <name>A0A1Y2AIN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIN4"/>
    <dbReference type="InParanoid" id="A0A1Y2AIN4"/>
    <dbReference type="OrthoDB" id="2564688at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="317" mass="34043" checksum="95A9E2051A10F45F" modified="2017-08-30" version="1">MEEEGDGSVDEMGQKQTIKLVFPPSETYQSLAPPLPPAASNKGSIRALRDKLSTLTSSRKLLARTGAPNKRRLEPVVVPPPSAPEWIRPRAVSPTSQLSPPLQPHLFFHPTPSATSIHGVLGRTESESGSDYGSDDDVKNSSHMRLPTIPSTAEKLSESYTAVPRKSPRTKGVKRVQTLGGMSKDISPVKVKRSSTAAAATTPSAGLRRSIAIPDLSSPERIRVSKRKSTATSPRKSRVQRKEERARDKVESILQASWSDRALQSPPLQESRSIQGQLDAAAGQGWVAGVGMNSPGVEEAAGAGIEQRLGMLKRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ12</accession>
    <name>A0A1Y2AJ12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_562407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ12"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ12"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ12"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="11">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="9">
        <location>
            <begin position="234"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="10">
        <location>
            <begin position="685"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY22177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="852" mass="97621" checksum="625E951304DE7FFA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ18</accession>
    <name>A0A1Y2AJ18_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">D-amino acid oxidase in complex with Two Anthranylate molecules</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_391722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ18"/>
    <dbReference type="SMR" id="A0A1Y2AJ18"/>
    <dbReference type="FunCoup" id="A0A1Y2AJ18">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJ18"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ18"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY22187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="364" mass="39671" checksum="05F739C0D81DCA78" modified="2017-08-30" version="1">MGATIMPTQGPSVNETIVVVGSGVIGLTCALILARRGLRVVIIARDLVADDPSQDWSSPWAGANWCPFGTDPKICRWETEGFARLHELVPAGLAMDLPIKRFASTEAGLHNHWYRNVVNDYRHLPSDQCPPGSVGVAFTSLSVNAPDYCKWLHAQCSALGVDFIRRELRSLEEVVGPDTKIIINATGLGARWLEDVRDENVEPIRGQIVLVKAPAVRTCTMDATLTTSEPTRSTYVIPRPNSGGQVICGGCYEVGSLKREVDLDLSRDILQKCLDLHPELAEKNGGVDSIKVIRHCVGFRPSRRGGPRLEMEALSCQHKKYFVIHAYGIGPAGYQASWGMASDACDLVDQALRRPLDGCDSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ61</accession>
    <name>A0A1Y2AJ61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_551188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000090">
        <property type="protein sequence ID" value="ORY22623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ61"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ61"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="106" mass="11434" checksum="631BD89D50908E06" modified="2017-08-30" version="1">MHNDTNPTLQRLLLDLLDLSRPSASVTCTYRSAHLSLLGLALIFRIGLSFTLILLVIGALVILVIAKVWHTAAHTTHTSCTAHLFHHLGLRRSAGNTTCVIGSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJK9</accession>
    <name>A0A1Y2AJK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_551715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJK9"/>
    <dbReference type="FunCoup" id="A0A1Y2AJK9">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJK9"/>
    <dbReference type="InParanoid" id="A0A1Y2AJK9"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="142" mass="16692" checksum="4E6A3D2AA1F7CF92" modified="2017-08-30" version="1">MSYFMTHLHSGWHVDQAILVEEDRVVCIRFGHDFNEDCMAMDETLYGVMEKVQNFCVIYLVDITEVPDFNKMYELYDPCTVMFFYRNKHIMIDLGTGNNNKINWPMSDKQEVIDIIETVYRGASKGRGLVVAPKDYSTRHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKA2</accession>
    <name>A0A1Y2AKA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_550337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
        <property type="protein sequence ID" value="ORY22983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKA2"/>
    <dbReference type="InParanoid" id="A0A1Y2AKA2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="89" mass="9866" checksum="7E79171CF5446731" modified="2017-08-30" version="1">MHCTMSTTYFFLVVASPTKSQTVITSDTFLGSTGLASDLAYLTGCVQSELHRLPHLPHGVRNCKSHEISVFDSVSCPSKQLDDYYHLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKM9</accession>
    <name>A0A1Y2AKM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_550133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKM9"/>
    <dbReference type="FunCoup" id="A0A1Y2AKM9">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AKM9"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000029">
        <property type="entry name" value="Integral to membrane protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22708" checksum="C2CF4C6BF6928329" modified="2017-08-30" version="1">MKENHAAENALGTIGAVLWSIQIIPQIVKSYRSKSTFGLSGALMFIWAVASLFLGSYNIARKLSIPLQVQPQIFGVLSAGSWAQCLHYGPRKFSKLKAGGCLAVFCVIFAGFESGSVYALWAGQNNGTDAPVLFYGYMSAVLLAVALLPQYYEIYKLKEVVGISLVFMAVDILGGIFSFLSLFFRNNLDIAAFVSPHAVNFLTFPNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKV2</accession>
    <name>A0A1Y2AKV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_551372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKV2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKV2"/>
    <dbReference type="InParanoid" id="A0A1Y2AKV2"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY22585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="483" mass="54203" checksum="1B30EDA27B941DBD" modified="2017-08-30" version="1">MTKDLQETWSDLILWLEGHKGFENHLAWRDVPGKGRGLFTTRRMKPDERLLLIPASAMINPLTLARDGHLPEHIFPQATSITRPSKKARAETVQRMNTTQLLTLHMARLRASPGPSKYAAYLATLPRSFRPWHPLTWLYPLRQVEDGEQAAWNDLFEKAPRVARQKLLEVKRRYEDDIDVIKEAQHDGPAYGHLASISTEDLLWAWLIVNTRTVSIPLGLPSPTELYNHTLVPLLDLINHTSNSALSIPKPRQVPNPGTMVNKRALSSGSSHLVPGKIAFELIAPSRGMEEDEEVFFSYGAHDAATLWSEYGFVESPAGAGATRWETMVFGGMDVGHWVEEVWKSLKPGGRQEKLDVLEAIGCWNHNALYTQPLPPNPSHGLMMTLRVFHLGTAGYDKLPAISRGEVTFISPDNEASVHSSLDGICSKVVTESELGLQALSQIIGCELPERKDAANMLEMMFEEQLWLARKIRERIRNGEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AND1</accession>
    <name>A0A1Y2AND1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AND1"/>
    <dbReference type="InParanoid" id="A0A1Y2AND1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="206" mass="22834" checksum="D9C2F2E7C0AB1488" modified="2017-08-30" version="1">MTTTLGLSEVPDLPQSPPPRTFHFVITTSHPTSIWERASNPRMPPFPVAIDDDVFLSSSSPSSTAPSSSDSECEGDRDTEFIIKGKRSGAESERRKRVYICHRGRAHHLRPYPTPCSPLSEISNDGTTEPSTPLGGVTRADDHSQQQCRGARQLVMTEPMSLAPDLVTVELGKSRRMQDTGTEAQVGPITRGRKRKVDEEIRQERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANZ2</accession>
    <name>A0A1Y2ANZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_472749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANZ2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANZ2"/>
    <dbReference type="InParanoid" id="A0A1Y2ANZ2"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="274" mass="29354" checksum="A087BC7E478A44E5" modified="2017-08-30" version="1">MSDLESARGRQPVVSTGRGGAGNLIRSPSRGVDPETTPGIELGREVRDGSHDRVTHSGRGGAGNVRSPSRPRDVIAEAREDALQDQLVADRRGRQAEAPFSTGRGGAGNIARSKSRSRSAVRDHHEHHDLHGVGRGGFGNIVEDRPQTPVDLQKEAAVRRYEADIAARHSAEEEVAPHSTGKGGAGNIGRPVTHVDMSTLTQEERDAYAKVHEHDVERGYTVGKGGAGNFIHPSKEHSPADGERGREKHGMLGNVLRSLSRAAGRDKSETRAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2API2</accession>
    <name>A0A1Y2API2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_546751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2API2"/>
    <dbReference type="STRING" id="71784.A0A1Y2API2"/>
    <dbReference type="InParanoid" id="A0A1Y2API2"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF5">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 5">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="168" mass="18294" checksum="256574621D968395" modified="2017-08-30" version="1">MLDGKKSVLVINGPNLNLLGIREPHIYGPETLQDVITAGMEQAGRAGAHVDFFQSNWEGAVVDRIQAARTDGTDGIILNPGGWTHYSIAIRDALLGVSVPFIELHVANIHAREDWRHHSVFHDKATSVIMGCGVKGYEFAISMILTQDKKFPAKENVSVKSEPGSNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2API5</accession>
    <name>A0A1Y2API5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2API5"/>
    <dbReference type="InParanoid" id="A0A1Y2API5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="473" mass="51065" checksum="EAB992A05175CCF1" modified="2017-08-30" version="1">MAQNQNSIVFNGQSYTVEQFLAIARFLPPTTGNHDAESSQTPSDQAAMSDSSGLATPASNTTGSTRYRSGQLARLMTSRTETARSNDLNNAIVVNSSDSDGEGDQAPLRHPIPQLANSRIKSRKDKHRRGLNNAGRPAPSLSNPGKVSQATVRLSKRGMVIFIPDRSLLEVSLSEQHIFELYCHCQALHLVKPVSLLKSAKAKEVQRAVAEAFEPELHILEDGFSWVDDSGKGDRLHETADSSRVDGHSLHSLYSSTANCFIVTKSLRRNPAFLDAFYKKCEKGTDDSSEEETLTICGSCQKSFTASTFTAHQQVCKHRTFVKQEPIEIEHVEPKPAAARAKRAKTPARPSIVADAPGSHFSRRLGDPRSERSGPVALPTTAVSPEGSPMSPTPTGTGNELSAQSASIQDAALAPEQPGEGPREESMAPSSQEEMVASTGATTSQVAVTAAKDSRRTPMKRRLRSHVSPDTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APT0</accession>
    <name>A0A1Y2APT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NLI interacting factor-like phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_547442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APT0"/>
    <dbReference type="STRING" id="71784.A0A1Y2APT0"/>
    <dbReference type="InParanoid" id="A0A1Y2APT0"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000270">
        <property type="entry name" value="Nuclear envelope-endoplasmic reticulum network protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="60"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="260" mass="28815" checksum="99798B9F48B15A38" modified="2017-08-30" version="1">MSNTSDSSDVDKPDLHQRRQPRLLPNPMSTSLLDPSLPAHSPAFRTSSPSLLRRTPAPTPFHLQKTLILDLDETLIHSTSRPLSYAASAGGGLLGLSFGGLLGGKGRRREGHTVEVVLGGRSTTYHVYKRPYVDHFLKKVASWYTLVIYTASMPEYADPVIDWLDGGRGLFAKKLYRESCHLHTNGSYIKDLALVEADLSRVCFMDNSPVSYSWNKANALPIEGWTSDPNDEALLHSIPVLDSLRFVNDVRRVLGIRGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQB5</accession>
    <name>A0A1Y2AQB5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_547762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQB5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQB5"/>
    <dbReference type="InParanoid" id="A0A1Y2AQB5"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF160">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="584" mass="61860" checksum="C56434C7DC46A036" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR55</accession>
    <name>A0A1Y2AR55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_507209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR55"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR55"/>
    <dbReference type="InParanoid" id="A0A1Y2AR55"/>
    <dbReference type="OrthoDB" id="2588229at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41568" checksum="7F54840741D1F52E" modified="2017-08-30" version="1">MGHRGGNVPPEDAISDRNLAGKNSAKKQRTTPAVSDEQVEQTLSHGQFDKAPIQTLRGLLSTTNPAQEIANDPIALGVLAIAEAQRICKVLGHGSSVSAPSIVTFGLPEGGGNTLAAGVLTSSVRSQQYWLHPRYADLLSIFDDHIKHFVIHPNSSDFTLKIIQALLLTTQWPPLDLDSGKLKSRFNDAYAWLMVGLATRLAKYIDLERCTETTFDTDEERARMRVWLNLVSVDRHCGPELSGSLTMTAGLPATLSAPPSKVLRTFGSHPKAQTGDLKLAGLAELIPIVEKASVACGDVFLRQLDPISLGMVTVEMDAWEKSWSTILQQSPNHLQQMPFGALKWYRLALNAIPIAAELGEIKLVGSTVPAALGAAVQAAYQLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARJ1</accession>
    <name>A0A1Y2ARJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Found in mitochondrial proteome protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_544995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARJ1"/>
    <dbReference type="InParanoid" id="A0A1Y2ARJ1"/>
    <dbReference type="OrthoDB" id="2580820at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="26578" checksum="BCFDDA04768B6CA6" modified="2017-08-30" version="1">MAGVVLGTGSGVLAAAAVYYTLSTSLRESTASLRGELANSNALLHSSFNSIPPPAASSLIGPSSSLGEPRFGDIVRQKWNTTLSSAFTSIRSTNYTAIGLAAWDSSKELVNQLSSSPSSSSPTTTSTSSSKSQSGSGSEGNGVVELLHDGVEKVKDSVKEEVEKGLQRASDGLHKVSEQVKHGMDQVRDGAELLEKRVEAAKDGGVALGTTTDSGPSIIAKPGQAESGLRGTESFTGGSAIVVKTQRELERNRGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ART6</accession>
    <name>A0A1Y2ART6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_546121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ART6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ART6"/>
    <dbReference type="InParanoid" id="A0A1Y2ART6"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="151" mass="16950" checksum="F7D3E3EADA8A0812" modified="2017-08-30" version="1">MPTGYRLEIASRSQASCNGRKPCKGSKIEKGTLRLGTWVEIQGHGAFKWRHWGCTTPEVIGHLKRDFEKPSDVDGFEELPEMYQEKFIKAWEVEHVEDEDIPATARLPTPPPGEEGEAETPKKKTPKKAKQPADGEADGDKPKKPRKVSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS19</accession>
    <name>A0A1Y2AS19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_544717</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS19"/>
    <dbReference type="FunCoup" id="A0A1Y2AS19">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS19"/>
    <dbReference type="InParanoid" id="A0A1Y2AS19"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY25276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="142" mass="15474" checksum="3F018F8BD76A0746" modified="2017-08-30" version="1">MASTIPVEQVSVPESSTSEKPLYTLDTLKEHGSRESMWMLLHDKVYDVTAFMDEHPGGDEVLLEEAGRDATEAFEDVGHSDEARAMLPKMLLGEFSGPKKVSKVKKSTDSTATGAKSSSGFPLWIVPVALVGAFLAWRVYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS67</accession>
    <name>A0A1Y2AS67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_566413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS67"/>
    <dbReference type="FunCoup" id="A0A1Y2AS67">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS67"/>
    <dbReference type="InParanoid" id="A0A1Y2AS67"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="235"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="491" mass="53992" checksum="37650AFB0DF2F25E" modified="2017-08-30" version="1">MSLATAKQVRSVLAKLWYVSPQSRLDELISTEQRIRTESFDDNGKPDEDPRFDTFPAFHKWLHDAFPVVFSIAEFELINTLGIVTTVRGSDPALKPIILMAHYDVVPAPNNTLEQWIHPPFSGHYDGEWVWGRGASDTKTLIVAQYEAMTALLEAGFQPRRTVIFSHGFDEEEPFARQGAAEIAKHLEKVYGFQSILLVVDEGAASMNKSGLSDVYGAPFAVPASAEKGYLDVKISVVGIMSDVVHAIEAHPWHPGFLACASEHSPNFPKRWSKMIQDEGKWNPSSRNTRADIASLVAALVTTTQAVDVISGGAKVNALPEVVEVLMNHRIALHNDVATVKEHLRKVLEPVAKLHNLTIAAFEAEGNHAHEIGQRYVQLQSYGASVDPVTRSVVAGPVWEMFSGTIRHVHPGINGRDTVVSPFATTGSTDTKVFLNLSRAIYRFAGGPETAHLSYNGHHTVNEKASVTAHLHMARWVHALIQNADAYDGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASD0</accession>
    <name>A0A1Y2ASD0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Triose-phosphate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_590176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASD0"/>
    <dbReference type="InParanoid" id="A0A1Y2ASD0"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="79"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="438" mass="48031" checksum="95C93499CEC30957" modified="2017-08-30" version="1">MSISSVNYLRTASIQQDQQPFLPRTILPNNSDYDDFDSNDMVEMQAARRSFQLSQAPQFAMDSTHVRRQKSVPPLFIIPAVWVGLSVLLVLFNKYIFSTLNFPYPLFLTAFHMMIATLSTSLIRAMPTEGLQVVSVDISWLTYLRTVVPLSIFFSISLVLGNMAYVHLSVSFVQMLKSLILLLTLVIQLVARLQAYSHYQMFIIIVSSVGCYIAASGEVQFDMFGFACQISAVVAEAARLVLVEVMLKDHKLDPLSSIALYAPLCLVFIGCMIPFLEGALPIDNLYKVGVLMLLVNGLVALLLNVASVFVIQSVGSVVLSMSGVVKDILLIGISAIFMGSHVSLHQVLGYSLSASALMLFRVTGGKLDSPAGQVVVYHAERVVSTPMMLFQRAPRLFLFLAGVATVAVLASSAVSWNHVTKKSITLVPLDDYTLNTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASU8</accession>
    <name>A0A1Y2ASU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_286564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASU8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASU8"/>
    <dbReference type="InParanoid" id="A0A1Y2ASU8"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32377" checksum="88E1A4A46C1C2F58" modified="2017-08-30" version="1">MSRDKVVVVTGANRGLGLEIARQVAAHPEPITLLAGSRSGQDLKLSTAHPSSKVLYPKLDITNDADIVKLVSVVQDLGGIDVLINNAGLSFETFGIEDKKEVMSKTLSLNYYGTAALIDAMIPLMHEGGRIVSLSSSASQDCKFDNDELHKRVTDPNLTRQQLDDLVKEYSVAGVDPQPGSGWSTSPYGPMYSTVKAFINILSRLVARDHPELLVNSICPGASYTTPRVQDQMPIKFKTAEQGASEAVRLALGDIQGVTGKYWAGDTLDSLHAHVIDDWMGREIKATPRELTDSPFNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATE4</accession>
    <name>A0A1Y2ATE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_566183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATE4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATE4"/>
    <dbReference type="InParanoid" id="A0A1Y2ATE4"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="257"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="399" mass="44077" checksum="49D4A5BBD3FC998C" modified="2017-08-30" version="1">MSDPDDNETKIALLASLLEPSTYPISDYLEALTAADGDVGRAAEEMLIPRVKSAGKRKAGTSLESWLGRKRSAVSRVKETTDEERKTSAQSLNNDQDGGTISTRSSLAPDLMSILRQPTTPPKTKSKTKNSPQSALVLTSQAAIDAHSLPVTLLQSPLPASLASALYLTMMQESENWESNKWFLAGKWVQSPHLMSSYARSGAEHGNAKYYYTGSDLGQFKDYPTLLKLAADMIEPVVNAALEKRARYPYEWAGKWRASVCGTNRYDGASSSVGWHADQLTYLGPYATIASLSLGTPRAFRLRQTESVDPAYAKDAKPIRTYEINLGHNSLVLMDAGCQERYKHTVPSQKALDLFRPAYDIDQQPIPPDAQKAYTSRINLTFRFYREGEEKLHIISGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUG5</accession>
    <name>A0A1Y2AUG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_470526</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUG5"/>
    <dbReference type="FunCoup" id="A0A1Y2AUG5">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUG5"/>
    <dbReference type="InParanoid" id="A0A1Y2AUG5"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="89"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY26238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="391" mass="43518" checksum="D1786F6CEE53E463" modified="2017-08-30" version="1">MKYKVDPTKPVVNIGGQPHALGKKEDVVAASGNKFTLKDLIGMGDGGTKLNRRPSASGSAKGSEKGGSTKGSDYGDGQSTASLLKKYGICDRAAIGKGATAVVRLAHKWDRREEKLYAVKEFRRRRKNETEKDYVKKLTSEFCISSTLHHQNVVETVDLVQDEAHHWCEVMEYCPGGDLYAAIKKGGMSSAEVECSFKQIMLGIQYLHSMGVAHRDIKPENLLLDGRGHVKITDFGVSDVFRMCWEKKTHMSKGLCGSEPYIAPELFDHKEYDARLVDVWAAAIVFYCMQFQELPWRVAKSSDPTFATYSSQYHAKNDAGNAMMPPPLNNLIPRECRNVLKHMLDPDPKARWGIDEALKDKWLAGIEVCEEGKENGHSHISAGMEIVKIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVH2</accession>
    <name>A0A1Y2AVH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_252911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVH2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVH2"/>
    <dbReference type="InParanoid" id="A0A1Y2AVH2"/>
    <dbReference type="OrthoDB" id="2507336at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="561" mass="58686" checksum="5790C9956E2E9002" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVJ4</accession>
    <name>A0A1Y2AVJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_542633</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVJ4"/>
    <dbReference type="FunCoup" id="A0A1Y2AVJ4">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVJ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AVJ4"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="145"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY25935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="344" mass="38968" checksum="AFF9CD70E448AC05" modified="2017-08-30" version="1">MSRPPNGRSYSALVDPGAKNSTLPSIHLDDTMTTPQPDQHQPHHHHGIMQETEAELTDDELIEYEKGILTWDKAKSWRFWIRKEWIWWYIVLIILVVLVALMAFFHHSIIDWLTPFTKRLQNLKAGFVIPAAIIFALSFPPLFGNEIVMILVGVVWGLGKGFAIVTVGTILGEVANYVVFKYWCRRRAERLTRKSLNYACLSRVIAEGGFIMATIVRLSVIPTHFTTMVFAVCGLKFYHFFVALILGLPKQLITVYVGVVLAKQNASTNSHVVSDCVFAATVVISLFALWFIYRRMTAVRKQVLLEMREDLRGKGVATSDPLVDGAVLQEDENRHQGFEPRNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW21</accession>
    <name>A0A1Y2AW21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_540983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW21"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW21"/>
    <dbReference type="InParanoid" id="A0A1Y2AW21"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000010">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.5, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="129"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="247" mass="26514" checksum="A5818B30274D88DF" modified="2017-08-30" version="1">MNRLNMNITGLISRPSFASSSSCSSTRTNLPVLLQRSYYHSASAPPLAPLRTSFHPTRPIRPLPKWIGTGTRSASTTTSNPGPGVGLGLPPSFPPRSRIKVTPPDLDAVKREGYLDEDVQLVPEDQAWLNLTPDAISQLEKITSREPADVLAKGKLALRVGVESGGCHGYQYTMALTEERGVDDYIMQPEGVNCIPVVVDLISLGLLKGATLHHATELIGSSFRLQDNPQAKEGGACGCGVSWEAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW39</accession>
    <name>A0A1Y2AW39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_589481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW39"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW39"/>
    <dbReference type="InParanoid" id="A0A1Y2AW39"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013254395" evidence="1">
        <location>
            <begin position="27"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="30"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="533" mass="58973" checksum="89FE23948BA65EFE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWL4</accession>
    <name>A0A1Y2AWL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_248154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWL4"/>
    <dbReference type="FunCoup" id="A0A1Y2AWL4">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWL4"/>
    <dbReference type="InParanoid" id="A0A1Y2AWL4"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="251"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY26876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="668" mass="73237" checksum="2FED96F64F4F1669" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXM7</accession>
    <name>A0A1Y2AXM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_538365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXM7"/>
    <dbReference type="InParanoid" id="A0A1Y2AXM7"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="156"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="298" mass="32739" checksum="6F7A36643038747D" modified="2017-08-30" version="1">MADGSQKSHALDDVYAAQPDEDYPGAKQRSRPGQGPYEEVYEKVLDPLTGRSVSLKPANKAFLASRARRAAHAASKPSSSIPTPSSNSATRSSMSSTNQSSLSWRQVLLVLLFLPLLSQFLTSTYTFTISSRLAPPLRKWWSRTPINIFRADFKEFTLDDLAKFDGSDPWLPVYLAIDGDVYDVTKNRRIYGRGGSYNLMTGIDASRSFVTGCFATHRTHDLRGLSPEELKSLDHWKSFFATHEKYTLIGRVLLPPIDPDSPIPPPCDDSAPGEAASARGSDAPGPVSETASPHHQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXR2</accession>
    <name>A0A1Y2AXR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative alpha-glucoside transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_539131</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXR2"/>
    <dbReference type="InParanoid" id="A0A1Y2AXR2"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="77"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY27080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="568" mass="63341" checksum="B3657A4EEA6DA54F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY02</accession>
    <name>A0A1Y2AY02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_538043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY02"/>
    <dbReference type="FunCoup" id="A0A1Y2AY02">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AY02"/>
    <dbReference type="InParanoid" id="A0A1Y2AY02"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="91"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="300"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="345"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="491" mass="53862" checksum="F743BEA5266E2175" modified="2017-08-30" version="1">MPKRTSDAAELSVSKSAATGQETARAAAVEDDDEMGEFEDRWEDEVEEEVVVEGDAEEDENDDEFTPAQEDSEPPPPPTQTYLPGIKLGPDEQLVPDNSVYLALHSLSYAWPCLSFDILRDNLGTDRATFPHTAWIVAGTQAGEVPGQGKAKDEVVVMRLGSLSRTQHDDEEDPDDEDDEDDDGEDEDATLDFLTIPHVGSVNRIRAQPTTSATQDPYLVSTFSETGKVHIFDVRPYVDTLSGPSKPRQKVPVHTISNHGRAEGFALEWGTTGLLSGDLASKIYLTTQTPTGFQTAANPYTSHTSSVEDLQWSPREPTVFASCSADRTVKVWDVRAKGRKSVVSVEAHEQDVNVISWNKGVEYLLVSGGDEGGIKVWDLRMFKGTPTPVAHFAWHTAPITSVEWHPTDTSVFAASGSDDQVTLWDLSVELDEDEAPQFTNGSGEQLVVPPQLLFVHQGQKDVKEIHWHPQIPGMVISTASDSFNVFKTISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYH2</accession>
    <name>A0A1Y2AYH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_537497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYH2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYH2"/>
    <dbReference type="InParanoid" id="A0A1Y2AYH2"/>
    <dbReference type="OrthoDB" id="2565254at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="451" mass="49025" checksum="0A8C5712F14A9866" modified="2017-08-30" version="1">MFAPASTHLPRTYSHAQTTGRKNLNKENAGALPSKTPSRAPGKLVPSTATRIGLGVKTVERDRNVDAPHLDGRGKGKGRDEDEIEPKRLFASTSKSIPPSKSLSQLAHIPNTHRTPAPTRRQPPSTTVKHTLRTPAPGPLIPESATATPLPSATRHRRRSSRQSLTPLKAAQEPDKSFVTPAPSGKWDEDLSLDSIHEVVQGVGLDEVAEVEEESDGEVEYMPPKVQEIPWEPAWEHPNLEPIFERIKGLPPLWGLGYEDSQMRTIKELEVESVKEQGIRLCSVEELEEPMFRKKAPEPAKIVNPARGHGVKTPVPAANRPVSRPVTSSTATQRREISKVPAVRRPLAATTKPLAATIKRKPLAATTKPIATTTKPIVATTKSLATTAKPLAATTKPLAATTKPNLTIRPRAPPIAAKPAAPKVRVFDDDLIGDMDIPEDEFVFDLGLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYJ9</accession>
    <name>A0A1Y2AYJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_537594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYJ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYJ9"/>
    <dbReference type="InParanoid" id="A0A1Y2AYJ9"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="98" mass="10638" checksum="BEAC06045E9843DB" modified="2017-08-30" version="1">MSFPKQLPAAVKELRLHLCQTSEASQGLRKFIQSQYPSIKTAHPNLKVLIREASGVEPKAFVRFERGAESQTSLANLSEKDVASALSTLVSSQTPGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYW0</accession>
    <name>A0A1Y2AYW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_537014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYW0"/>
    <dbReference type="FunCoup" id="A0A1Y2AYW0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYW0"/>
    <dbReference type="InParanoid" id="A0A1Y2AYW0"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="137" mass="14640" checksum="400A46ADD502E6B7" modified="2017-08-30" version="1">MTVHALWVINKAGGLVFSRSYSDTLPPLPLNTVLILAGTLHGVHAITSRISPGGGGGGMESFEAEGWGGRVFLTATGTKFVVLHSLPHPGLEELLLKVYEIYADAVMKNPFHTPEMPINSSLFETRLQALMIAANTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYX9</accession>
    <name>A0A1Y2AYX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_537137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYX9"/>
    <dbReference type="FunCoup" id="A0A1Y2AYX9">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYX9"/>
    <dbReference type="InParanoid" id="A0A1Y2AYX9"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="217"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="377"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="503"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="618" mass="68513" checksum="6690553020703752" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ62</accession>
    <name>A0A1Y2AZ62_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_559866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ62"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ62"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ62"/>
    <dbReference type="OrthoDB" id="2573513at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="722" mass="82445" checksum="9543EC14B8B9247D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ71</accession>
    <name>A0A1Y2AZ71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_536503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ71"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ71"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ71"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="536" mass="57558" checksum="A91D0C82D1851145" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZN2</accession>
    <name>A0A1Y2AZN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_506029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZN2"/>
    <dbReference type="InParanoid" id="A0A1Y2AZN2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013276970" evidence="2">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="132" mass="15610" checksum="3CAA341854F3994D" modified="2017-08-30" version="1">MALLLGTFLLFQLWRYVQVKKTEDIRIPKRKWIAFVQVLLGLLVFMLSCGDIIVWIIARNRHQDLNPDVLGYFMIIFGILLSAIWIFTVPAAYAYRWPTVQVQYQDPTTKQTTSEWKLRKLTSWDRLFGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZR5</accession>
    <name>A0A1Y2AZR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_536433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZR5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZR5"/>
    <dbReference type="InParanoid" id="A0A1Y2AZR5"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="235"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="137"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="574" mass="64251" checksum="EE889CF04CD4F01D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B043</accession>
    <name>A0A1Y2B043_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_535986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B043"/>
    <dbReference type="STRING" id="71784.A0A1Y2B043"/>
    <dbReference type="InParanoid" id="A0A1Y2B043"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="657" mass="73873" checksum="E5C749B224EC3981" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B084</accession>
    <name>A0A1Y2B084_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ferric reductase like transmembrane component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_535691</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B084"/>
    <dbReference type="STRING" id="71784.A0A1Y2B084"/>
    <dbReference type="InParanoid" id="A0A1Y2B084"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012033641" evidence="13">
        <location>
            <begin position="19"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="421"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="684"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY28146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="781" mass="87958" checksum="2C8C4EC8E2975A66" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0X7</accession>
    <name>A0A1Y2B0X7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_534797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2B0X7">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0X7"/>
    <dbReference type="InParanoid" id="A0A1Y2B0X7"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15725">
        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="18"/>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="PROSITE" id="PS50178"/>
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    </evidence>
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            <dbReference type="EMBL" id="ORY28463.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2030" mass="223050" checksum="00E05629D0B099A5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1A0</accession>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B215</accession>
    <name>A0A1Y2B215_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Meiosis protein SPO22/ZIP4 like-domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_535556</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORY28125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50470" checksum="D05E2B9E19BBCF20" modified="2017-08-30" version="1">MACVRKAALCFINAGDFAQADEVLRSCAVDEAATQYLLFLAAIKQGLEDKAIAAVRNIVRCPDLVGKQLLLMASLSHDKGYSNILRCTLDALVMTIKAGQIDPSLQVETIAVVRCLIRLTLIELDKAKIEQVPALLNSVKQHFELTLDVLEADDRDAKTPTTEMEWLYKTAFNTAISYADYGDQPTVTDIFNVSGMLMELYEKASPSEAVDIELPINKAAAKFACLCGKLFVYREMPEGDDKAILLQQLAAYLPQCRFDCQCAWLTKAHVNHLDYMLRVIDVFEIEILATSRDWDGVTTAMIEMIKRRTEAGEADPDSSLETAADVLLSFANCPSEVTLGVIEVLLDAYSMDSLRDATRVARWIRAVLVGLLGREDSESEKKALHYVQKALDVLRKEDSSIVYPRDEIAWLAAQTWNTGLEKANSVGIDHARAWCGLALALAPYTPEGAAALTSVSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2B5</accession>
    <name>A0A1Y2B2B5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRPBCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_559263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2B5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2B5"/>
    <dbReference type="InParanoid" id="A0A1Y2B2B5"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18195" checksum="485A6F016FDB5BC4" modified="2017-08-30" version="1">MPITSEIIIDAPPQVVRQVLLDFPTLRDWHDGAHFEFIEVLAPGRKSGIETVKGDRVKVKVPWWPLPFYSTVQENKPNRFVWAAGSSLLLLGRHEYTLNPDASGNPNRTLFSQSEGFVGLLSYFIDSPTSMAGKKTLQGFEGFDRDLKAGVERIWQERHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3A4</accession>
    <name>A0A1Y2B3A4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">BCR39DRAFT_532226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3A4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3A4"/>
    <dbReference type="InParanoid" id="A0A1Y2B3A4"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24007">
        <property type="entry name" value="ASKHA_NBD_eukNAGK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="6">
        <location>
            <begin position="271"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="611" mass="65466" checksum="53481B0B0F6F67CB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3V8</accession>
    <name>A0A1Y2B3V8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_531941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3V8"/>
    <dbReference type="FunCoup" id="A0A1Y2B3V8">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2B3V8"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="946"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="972"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1062"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1130"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1161"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1190"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1236"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1264" mass="136225" checksum="485941464AABFE86" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B427</accession>
    <name>A0A1Y2B427_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_588615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B427"/>
    <dbReference type="InParanoid" id="A0A1Y2B427"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="498" mass="55526" checksum="FF72C0A5B69B4159" modified="2017-08-30" version="1">MSSQDEYAPLLPSTQSTPPAMKTRKPLYIGFSVIITVLLCAITAKTTTLLRKPATDPAESFWHNVTEFGPYCDGATKGWSGWIGLDVEGAGVKRSFFILNLAEEDHEHASLILTIGGGPGTSGHTRYWTGDGPCLITEHGLEPNQHRWTENFNYLAIDHPVGVGFSYGNMVNSSADAAKEMYDFLQKFYVLFPQLKDNQLVLNGGSYGGMYIPHMANIIIAQNSLLAAEQAPKGNVHIPLESIMISNPWSDPLSHAGGLIEMLCQQTHPPVWNSSQCLSAYQALPSIIQAVRLALDIPTLHNRVKALNVTWDVELMDLHGVKRENYHERCDGSTAECYPYFIHMQDFLRNISKDLGVPEFLKYNTTSDTILELFVENGDFMQQSTRFFPTILSNGIRILHRVGMLDMNCPWTTVLNSASSLHPLRLLLTPIVQQSEFTRQPDVPWPGEESEATIRVVGAGAGDFTYVQLLNAGHMVGHDAPRIEKKLAEHWVYNRVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4J9</accession>
    <name>A0A1Y2B4J9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small nuclear ribonucleoprotein Prp3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_530877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4J9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4J9"/>
    <dbReference type="InParanoid" id="A0A1Y2B4J9"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="144"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="23984" checksum="448C85887303E0E2" modified="2017-08-30" version="1">MSGLLEESLDTISILQAMYPLPTELEIGATTAAYLLDPSRTPPNILEIVLNLLVDEDEVHPLSIVIGLPVKSDDQVKISPRQPAWLNRMQHDSLLSSIPPCDAPDAILDTIESIKASASILLHSTRAPTPPPVEKVEEVLERVWFWFPSLSTREKRRDLVEYAPRYGLTGFVLAGKPGLLCLEGDAKQVDHYMSSIKSESWSDIPSHQKKVGVLLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B539</accession>
    <name>A0A1Y2B539_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MmgE/PrpD family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_163896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B539"/>
    <dbReference type="STRING" id="71784.A0A1Y2B539"/>
    <dbReference type="InParanoid" id="A0A1Y2B539"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="305"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="52794" checksum="F75AE1D6048E85BD" modified="2017-08-30" version="1">MPIADTDQPHVLVKDNSLVDVGMAKPDSNSNNHLEMDGPTHRLAHWATTLPRERTVEVQSEAVDGFKDLMICMIGGSAEPTARTAANAAAQTGTGPCTIIGDAAGRKTSAAWAAFANGAAAHILDFDDSFGPLQGHVSVTIIPALLALAEEQHASGSDLLDAFVVGVEAAAIIGRANTTTYNVGWHNTAVIGVVATAVACARLLRLNTRQVVSAIGVAVSSSSGNMSQNGYDVKSLQPAFAARDGLFAAVLARSGIVGGPETLAGPMGFSSLYSPMGEGAAERYVIPRHDQPLSIVDPGIIYKPYACCGDMHRAIDAAFNLVIDHDIQSQDVQAVDIALPFNSVRNLPYVRPTNSAQARFCVPYNLALVFFNRQITLSDYDDVSLNRQNILDFIPKVTLRVIPDSENSPHTTYLDFPNEVTVILHSGKVYRQSQMVRKGDRKNPMSPKDWKGKIDGCLRRTLSPERAAAVLRCIEGSADLNDVGELTVLLRGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5B1</accession>
    <name>A0A1Y2B5B1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_530670</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5B1"/>
    <dbReference type="FunCoup" id="A0A1Y2B5B1">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5B1"/>
    <dbReference type="InParanoid" id="A0A1Y2B5B1"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="324"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="599"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="809"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY30022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="877" mass="96804" checksum="27DF7309CD11E5B1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5J0</accession>
    <name>A0A1Y2B5J0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_530291</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5J0"/>
    <dbReference type="FunCoup" id="A0A1Y2B5J0">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5J0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5J0"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="93"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY29956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="458" mass="51618" checksum="5CAFF19BA2C7F553" modified="2017-08-30" version="1">MVSRSLDRIWIGGTISLISFIAFSSQIFVVWPQYGREFSVDLIKLLFPFNCLIFMVFWNYRLCVITPPGGVPQGWRPDMSSLDGMEVKRGSHAPRFCKMCEHYKPPRAHHCRQCKTCVTSDHCPWIANCVGFHNQGHFIRFLFWVDLATSYHLFLLVNRVFDLSKMAVDEPTLSDVLFLIFNFAACAPVWICVGMFSLYHLYLASDNTTTIERWEKDKVATLVRRGKIREIAYPYNIGTYKNLQAVLGPNPFLWLWPQTMKGDGLSFPVTPDAGDMSVQYLWPPSDPTRLTNPPPPDASASPFVYGVDSLNPHLRPSNSAMRADCSNPQWDSDSDSERQSSSPEPYLSDYDDARWGPGPGPGPASTQRITGRRTHVRQGSEGLEVRSVPAWDSAGWNEDVEGRLGARPWEEDGRYNVYEPEVDSGSASGDDWGNGNGNGNANDSNRHPEPRRIDLKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5R3</accession>
    <name>A0A1Y2B5R3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_494785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5R3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5R3"/>
    <dbReference type="InParanoid" id="A0A1Y2B5R3"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29625" checksum="38F8C900156BEFC1" modified="2017-08-30" version="1">MKLENKAFVITGGCGAIGGGAAKAILARGGIVVVLDVLESAAGEAKVRTYHPDRAYYFQTDIADVDKVSAALDLALKVIPKGSLFGGVHCAAIAPARPWTNKMKDSCADFSKVLKVNAYGTFVVDACIADAINSQYPDEGPYAVRVSEERGCIVNIASMVARPVPGRCLTYGPSKTCVLGISSAASDYLGPSAIRVNTVSPSIVASALMGDRTAYFEAEVEAAAIYPRRFAVVDEVVSAIVYLLENSMMNDFDFRIDGGWRGGTNWAAEKDPRSNAPALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5W2</accession>
    <name>A0A1Y2B5W2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dicarboxylic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_530110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5W2"/>
    <dbReference type="InParanoid" id="A0A1Y2B5W2"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="201"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY30231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="31301" checksum="501BB8947815E7BC" modified="2017-08-30" version="1">MTEVAAVEPQQKSHPVWLGGASAMMAVCITHPIDQTKIRSQTQAVRRGMIETARNTVRGGGVIRLWDGLSGSLLRQATYSMARFGVYNYLKDRDRRAGRPKSRMRLVGNGAVAGLIAGLIGSPAELVMVRMSADGVKPPEKRFRYKNALDGLIRIAREEGLSSTFRGWGAASLRSVIMNGSQLSCYDMIKEALFKTGYFSDNVPLHLLTAVLGGTIAVTAVAPVDVMKSRIQFSSSPGTSAMSIVSTSLKQEGFSVLFRGWLPAWLRMAPTTMLTFAFFEQMKRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B696</accession>
    <name>A0A1Y2B696_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_529449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B696"/>
    <dbReference type="InParanoid" id="A0A1Y2B696"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="99"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="195"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY30361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="299" mass="31718" checksum="5955B08F4BD0A96F" modified="2017-08-30" version="1">MAGQKSYPFWLGGAAASMAACCTHPLDVMRVRMQTSTEKTTFIHAIRAVLSQSGIRGLYTGLSASIFRQMTYSVTRLGAYEALKTAMAGAGKRKLSTAEMVLCASAAGALGGLAGNPADIILVRMVADPTKPPAQQLHYRNALQGVYKMTRDEGVMSIFRGLAPNTIRAILMNASQLVSYDFFKDALLSNTSMTNGLPLHFLSSAAAGTVATTICAPADVVKSRVMNAAPGGAGPIALLTESLKREGPKFLFKGWLPAWIRLTPNTICMFVFLEQLRKAVDLIRKDPETAAAAAAGGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6A1</accession>
    <name>A0A1Y2B6A1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_530531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6A1"/>
    <dbReference type="InParanoid" id="A0A1Y2B6A1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="89" mass="9950" checksum="42F3886D81B645E5" modified="2017-08-30" version="1">MDPRFLNNPPLFTPLPLLCMIRCAMSSVVLMISSLLRTDRSTANQGGTVQRRTMHCYFLLATTSYRVDAGFYAVTSRTQGTYWPTPPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6Z5</accession>
    <name>A0A1Y2B6Z5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_494579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6Z5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6Z5"/>
    <dbReference type="InParanoid" id="A0A1Y2B6Z5"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY30611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54010" checksum="9212EE935DC1E9E5" modified="2017-08-30" version="1">MSTLSTRELSLHERFSITRRNCGFPHGLTFIFSYSSESSVPTYTQLCSRVEELQKHFPLLWARVIDSKTKNPKFQARQRPWRGEEIVSQATYTVKDDKDLEMERILYESSAGMDKLDDQLDPLWKISILRPQQEEQDSTGSRSYITVAGMHELVDGRGLMNLSLAVVDPGLDISQLPYETIDTIPLLEDTISLKPSLTHLLPVVLRAIVLPRLPYFIQNVFKEITPWPANLIKARPTESPFDLSLLAISPDLVSGLKKAGKSHNVPALHATLQIAYLVAIWAKFENELNPFVLGMATPLAERNPKLSHAYCTANYVSSYSETIVPSSSKSFWQTASELSTTLRSDAGRAAARYSMGMLAYIPDGEQDPSKKETNRPTGWESFFLQGAEGPTPYSIALNMSNLGYIKLPQGCDDAVWGQMASPFGPAFAVDVLGHEAGLKFVTIWRDGSAIDRTQVKEVETVFKKVLERLADEDWNDLTFGGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7R4</accession>
    <name>A0A1Y2B7R4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_528993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7R4"/>
    <dbReference type="InParanoid" id="A0A1Y2B7R4"/>
    <dbReference type="OrthoDB" id="2572490at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="508" mass="56509" checksum="C1C178C6491F7FBA" modified="2017-08-30" version="1">MSTSAPTTQMILPPAPRGSHPVSFQLWRSDGVLLPIQTSHDHSESLLLGKDSHGNQLVSFGGDPSSESVNQASANETRRRRHFPDGAGGRIVKETAWSIGENGVMWIEPEGTSFSDYDVSIPPFSRLLSATRDFLSSRREAFQFRRTKRLFDIMRYALGLRADFPGPHWSGCRGQDANDNVKEIPSESGEVCVLLTRPVDSIRGFLALARREAEAGWDFEPALKLTRIVAAFMAFIKHHEVITDPHLVAGFSEATLIARGAPEALICAKDFEDTICDGNKWNRASWILWGGVYQGPERGGTESEARWGYIPTREESTTGGFEDDGGWKVDPVDDNGPEPVTEQQAWSAIAPLIAPVQQSQIALLEYIPFARRRISRILELPTERSPTFGTTLWPILTVPAPWTSSEKWRVHHAGNTALEDLDNKVNSPKLDLEKEVPTIPEPNEIVLWVEAQAVNPDLVGMALRGRWAMMGTEDRTASWWCFKPKDFVLPAFWQASDDHSEEGNGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B906</accession>
    <name>A0A1Y2B906_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA recombination and repair protein Rad51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_527022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B906"/>
    <dbReference type="STRING" id="71784.A0A1Y2B906"/>
    <dbReference type="InParanoid" id="A0A1Y2B906"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="51" mass="5470" checksum="FC74A10456E50147" modified="2017-08-30" version="1">MAHASTTRLSLRKGRGTSRVCKIVDSPCLPEAEGIFAINPNGVGDPEEMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B986</accession>
    <name>A0A1Y2B986_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_457583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B986"/>
    <dbReference type="InParanoid" id="A0A1Y2B986"/>
    <dbReference type="OrthoDB" id="10520404at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013390785" evidence="1">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="132" mass="15193" checksum="27837FC4F945DC5D" modified="2017-08-30" version="1" fragment="single">THNFHAIKLSLHLILHCAMAYFCHINIPLLITDIRVPDTTKPRQHLYTSFIEFLTSDDKNQILVHAYTVETLALNEVVSFWGSLAHDGSITSPLEVYASSFERFDWVDLNDEDYFTKVPSCRRPMIIAQGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9I7</accession>
    <name>A0A1Y2B9I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_526636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9I7"/>
    <dbReference type="InParanoid" id="A0A1Y2B9I7"/>
    <dbReference type="OrthoDB" id="2566935at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012982819" description="Purple acid phosphatase N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15119" checksum="4D7AF19254A8FFCC" modified="2017-08-30" version="1">MLHRLSLFLLLILSISLTFTSAAPIPPHHSSYYPYKPVELTTHFRGSVVPAQTSVQIAWTGGSGQGYEVYYIPQWPGQKTYAPVDIARTSGNSVTWQTPSIDRWPEGTTFIVGVNDVLEGSGSSWYALTRLLNFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA29</accession>
    <name>A0A1Y2BA29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_526180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA29"/>
    <dbReference type="InParanoid" id="A0A1Y2BA29"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF74">
        <property type="entry name" value="AGR407CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013231600" evidence="4">
        <location>
            <begin position="20"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="124"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="582"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="744" mass="76518" checksum="97371531D71A648D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBC1</accession>
    <name>A0A1Y2BBC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_526380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBC1"/>
    <dbReference type="FunCoup" id="A0A1Y2BBC1">
        <property type="interactions" value="757"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBC1"/>
    <dbReference type="InParanoid" id="A0A1Y2BBC1"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="284"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="782"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="916" mass="100360" checksum="BB6B837CF1369C0C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBJ1</accession>
    <name>A0A1Y2BBJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_587178</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBJ1"/>
    <dbReference type="FunCoup" id="A0A1Y2BBJ1">
        <property type="interactions" value="794"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBJ1"/>
    <dbReference type="InParanoid" id="A0A1Y2BBJ1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="419"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY32193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="515" mass="54774" checksum="D4C5EBCF6758CC6A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC00</accession>
    <name>A0A1Y2BC00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC00"/>
    <dbReference type="STRING" id="71784.A0A1Y2BC00"/>
    <dbReference type="InParanoid" id="A0A1Y2BC00"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51025" checksum="D8FC0C0823FF09DE" modified="2017-08-30" version="1">MSADTGPVPLRLPAILQNPTNPSIRQVEAHNAQQREKAIARRDRASQGDGSRVRGPGKRVIRRRENATFTSNPHVVAPTRADYMPSVPLQSRPLHASFPPSALPRSIPIPPVDIPQPDPSSISSKSGTFSTSLKGTRALLRKRGRRAEYLVALVEGQIQNWKNGQGWLDSLHSTENWKILDSTLVENEEILKGESDESVGEGSTSTRRMPALHQIQTRLPPLPTGSRAAVLELSRSPAHLTWAVADSFDRLVVHLVARYYELVSWSDDHITTDSHKVRLTHMVVPSLSSRLNPVPSHALLTPETSDLSGQSSSETPIHTESEYSDDDETETEQGSVVGYSLESESEIEPQRRAESESSPTPIPELIHRLDEIHLIPLERTISNGSSMYASESDPEGSEYGAMGDSLTLPSRTENDGGWTSVVYSEQRLPPPRTVMREQHLRVQNVKRGTDKPSFFEYLYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCH4</accession>
    <name>A0A1Y2BCH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_593015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCH4"/>
    <dbReference type="FunCoup" id="A0A1Y2BCH4">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCH4"/>
    <dbReference type="InParanoid" id="A0A1Y2BCH4"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="185"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="333"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="721"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="759"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="765"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY32523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="811" mass="91992" checksum="BF60D66710183D44" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCH9</accession>
    <name>A0A1Y2BCH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_376013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCH9"/>
    <dbReference type="InParanoid" id="A0A1Y2BCH9"/>
    <dbReference type="OrthoDB" id="368507at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17401" checksum="1016717D9C7EE2AE" modified="2017-08-30" version="1">MTDLTPSITTHHTNIPSPLPSSPSFVFHLTRLRDTLMLWVGTGPPSDGSFAAGLSDTVPSTSIEEKKIAAEWAVGMPGRGSIPVTSTPIYRSGTSDLAVPLSSRLARRFPPNQIHLSLSLPTSLTAQSGPSLDPFANKVLLVMEKKLVAWIEEVLNEEKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD58</accession>
    <name>A0A1Y2BD58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD58"/>
    <dbReference type="InParanoid" id="A0A1Y2BD58"/>
    <dbReference type="OrthoDB" id="2564568at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013208878" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="22071" checksum="EFBC26819A3D27B5" modified="2017-08-30" version="1">MFAKGTLVALGALVGATVSTAQNVHAVRSLISRQLSTSDIPSACQSECTQTVTIYNACVNDDTTGCLAVCEQDTFNAFVNCFTCVLEDSSGVDANSYQSIADSVAELQQACTAAGATLTPTSLVPFQSLSQTATDIATDTTGAIASVTSDDGFSFTSAASGGVTIGAGAPSTGAPSGAVASTTPVTSVPLASSAPASSAATTDAAPSVRDIHSCIGTLLITHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDH0</accession>
    <name>A0A1Y2BDH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_583310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDH0"/>
    <dbReference type="InParanoid" id="A0A1Y2BDH0"/>
    <dbReference type="OrthoDB" id="10658375at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="185" mass="20766" checksum="92E74FFDFB56E59D" modified="2017-08-30" version="1">MSVSVSPLPRAFLSLSRSLALSLSLFQFLYLALSLLVWVSAQKMTSVFSHNVQHAKVILHSRHDFFALITLLVEAERGYLFWTTAAGYRINLDGLIEGLLTMYTIKTFDTTAGHQHWVKAAPHHMVTVNKRFKKTIYMAYDNIAGRRLAISRAGDGLKQLVLFIGGDYRKGLAFAEHHGCEIVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE29</accession>
    <name>A0A1Y2BE29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_521150</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE29"/>
    <dbReference type="FunCoup" id="A0A1Y2BE29">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE29"/>
    <dbReference type="InParanoid" id="A0A1Y2BE29"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="454"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="697"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="163"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY33088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="780" mass="87137" checksum="8A8D3E3794A22076" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE33</accession>
    <name>A0A1Y2BE33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_521073</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE33"/>
    <dbReference type="FunCoup" id="A0A1Y2BE33">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE33"/>
    <dbReference type="InParanoid" id="A0A1Y2BE33"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="16">
        <location>
            <begin position="271"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="129"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY33081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="500" mass="55447" checksum="735860343313E76E" modified="2017-08-30" version="1">MTSNGFKSPAPVLPAMGLHSFHNDSPPFNGAGIVANPEPEYLSLDDSQTLPPRPQARPFGTSSQSAQKVTQMTTFPREVDLSVSNMVAPMPIRIGSPLIDPQGQQGGHHREVSNTDENISLSRSRRLVSGYMFGNPPSPVDSRPPSTAEELYHTPPSLGRDSPPLVDPRTTQVSPTESEEAPFDVEETIGEGSAQLSRKKSEKSRDRETGYDALNGLNDGEADLDESAPQAEGSTEAYLRGAGGEAGQYGFPRHRLRTTMKDESKIPIVIVACGSFSPPTYLHLRMFEMAKDEILESQTYEIMAGYYSPVSSYYKKSGLAPAVHRVRMCELAVEHTSTWLMVDPWEAGQSEYQRTAVVLEHFDEMLNSQGGGIVMSDGKKRRFKIMLLAGGDLIESFGEPGVWSEPDLHIILGRFGCLIVERAGSDVWAFLLSHDILYHHRRNVIVIKQLIYNDISSTKVRLFVRRGMSIKYLLPNSVIQYIYDHKLYRESEVKAVTQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE43</accession>
    <name>A0A1Y2BE43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_521173</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE43"/>
    <dbReference type="InParanoid" id="A0A1Y2BE43"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="557"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="12">
        <location>
            <begin position="1647"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="2036"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="755"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY33092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2119" mass="238855" checksum="9A1266151018D571" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE53</accession>
    <name>A0A1Y2BE53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative importin beta-4 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_520902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE53"/>
    <dbReference type="FunCoup" id="A0A1Y2BE53">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE53"/>
    <dbReference type="InParanoid" id="A0A1Y2BE53"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="10">
        <location>
            <begin position="340"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="911"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1085" mass="118537" checksum="FA8EA0BE00E365B9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE77</accession>
    <name>A0A1Y2BE77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_586696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE77"/>
    <dbReference type="STRING" id="71784.A0A1Y2BE77"/>
    <dbReference type="InParanoid" id="A0A1Y2BE77"/>
    <dbReference type="OrthoDB" id="2578778at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="64"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="274"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="372" mass="41494" checksum="79EEAAE7DDA126E1" modified="2017-08-30" version="1">MSNQAPPTIDETSLRPDLLESFKLPRASPPNFTDHIFKIVNGLELGIRVWPAENARYPAPFITWHHGGGFIAGSHWAPLPWMEPGLRQRGYHIVSPAYRLGPQATIDDQVEDCIDSITWCRTQLPSILGQDKVDIDRYVICGESAGGALVTLMGHRQLSPPPKAIINVYGAVDLLDPHFGILDKRDSHTATEPWNGEFSEQEIVAALSDHDPTHCLADALSWNEQERCSDREISKLWATDFTFSKPIRLRAEVHIYRSTRLSLASCLHTEGFKDDKEFHAWLRSVSALHLLGDKKTYPPTAFLHGTADSAVPLSQSQKMASKLRSMGVPTVECYESGGPHVFDNVYKSPSVAGWDTYIQPILDFVDKQLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE81</accession>
    <name>A0A1Y2BE81_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_521422</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE81"/>
    <dbReference type="FunCoup" id="A0A1Y2BE81">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE81"/>
    <dbReference type="InParanoid" id="A0A1Y2BE81"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="432"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="599"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="673"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="707"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY33138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="724" mass="81555" checksum="FF8E362BAE85A002" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF20</accession>
    <name>A0A1Y2BF20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_519744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF20"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF20"/>
    <dbReference type="InParanoid" id="A0A1Y2BF20"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="125"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="355"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="430"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="478"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="517" mass="55099" checksum="DB3D6443608BA4C6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF67</accession>
    <name>A0A1Y2BF67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_519394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF67"/>
    <dbReference type="InParanoid" id="A0A1Y2BF67"/>
    <dbReference type="OrthoDB" id="2434934at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="336" mass="37217" checksum="45A6D9915CB1F3E6" modified="2017-08-30" version="1">MPIPNPFTLTLTSISLQPRQKPQQQQTTPTKTRSDSTLKRKALQYYATWTPAKTRRATKAAIALRELILEPSAGSESLSPSTRTTTLPRLREKDVERLRTQLLKPSEAGAVIQQARTLPVRARQGVEPMRAVCLDCGDGQAEQLIRGARQRHAQEKHLAEHRFSTIKSPPLPLARLPVLLSLLQPKEYQHVDTTIPLGLFLPASAMSLHRPLAGALPSAETLRRGFDALLNAESKVYLYEGPSHAGISPPVDRLSIYTYWWGFELALPPPTLEYLSRAKQISISVLNLLSIVVYAVPGGTRELAPFVGVLSRFIETEWAVLKTQDKGRGVVCGATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFD2</accession>
    <name>A0A1Y2BFD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_520476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFD2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFD2"/>
    <dbReference type="InParanoid" id="A0A1Y2BFD2"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="321" mass="36176" checksum="83E1A9EB1475C89F" modified="2017-08-30" version="1">MSSRACIAKRRIQNPTCSLSRLVFSTVTSSQSQAYSSSTHRSTHLSITSTSQLHRSNTLLCTCHLTSTFPITPIFTTYSATRNHRYTTTTAMSDTDDQIPEIILKTRQAASGKTGESVEPRQTLPTEDMEPDPSKSIPLPPNRQKLIDDVIALYSCQPTVERVARYAPACVYDDQFVYANDRYKMAGQWFGLPKLFPKSENLGYEITKNDDTLIQFKNKQRWSFHLISKQATINALVSLELDPATKDSDFPLILYHKDQANEKDYSHEGFGFKFKKFQADIVSGLMSQKEVKYFKGDENAAKEPVKKYGSGTAQAPLEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHR1</accession>
    <name>A0A1Y2BHR1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative actin-like protein ARP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_517782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHR1"/>
    <dbReference type="FunCoup" id="A0A1Y2BHR1">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHR1"/>
    <dbReference type="InParanoid" id="A0A1Y2BHR1"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="736" mass="83669" checksum="2F182A11437E41DD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI31</accession>
    <name>A0A1Y2BI31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_463326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI31"/>
    <dbReference type="InParanoid" id="A0A1Y2BI31"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="514" mass="57756" checksum="AA4D78E4355A26C1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIP1</accession>
    <name>A0A1Y2BIP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger protein 830</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_585618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIP1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIP1"/>
    <dbReference type="InParanoid" id="A0A1Y2BIP1"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30599" checksum="47DDC835888E4360" modified="2017-08-30" version="1">MDARSLLRAKKAEARIEHPYASYTSRGDLRCSVCAVPVKQWDAHILTKQHRTSVAREKALAERASTKRAAAEQGGNMKRQKVGSTSTGGGGVDGLPAGFFSSENQRNINISSTANDDDEEAQEEEEPSTTSTTTSRKDPTLIQPAPTLPAKTGDADLDDFLASLAEPEPNPNPNPNPTLPGSSYTTTISGVASYEAAPILNIVDTQTEVEERDPEPEETEAERRARLAREEREEIMGRLEEEERAQEDADDRVAALKARMEMIKKRREAKAGSKPKIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJH4</accession>
    <name>A0A1Y2BJH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_585871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJH4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJH4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJH4"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="289"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="517"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="783"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="802"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="882" mass="95739" checksum="B9EF28EE69A105B1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJU9</accession>
    <name>A0A1Y2BJU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dialkylglycine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_516385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJU9"/>
    <dbReference type="FunCoup" id="A0A1Y2BJU9">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJU9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJU9"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="444" mass="47885" checksum="AA9D39C0D58C20D4" modified="2017-08-30" version="1">MPATTLNSDSFWQEADASLIRYNGAGDFVRRVIVKARGSTMWDSDGNEIIDWTSGQMSSMLGHSHPEIVETVADSMSTLDHLFSGFVSKPVVDAAVMLGSILPPSLSKVIFLNTGAESNEAALKMAKLYTGKHEVVAFSASWHGMTQAAAAATFSAGRNGYGPNSPGQFVLPTPNAFTSPFRNSDGTYDWQTELAYGWNLIDCQSTGSLAACIVEPILSSGGVIEMPAGYMKALKNECEKRGMLLIMDEAQTGLGRTGDMFAFEHEGIVPDILTLSKTLGCGLPVAATVTSAHIDQVAHEKGFLFYTTHVNDPLPAAVALKAMQIVVRDQLHFRARELGIKVKSALRELQRKYKCIGDVRGRGLLLGVEIRPNPNIPDSQPAHILGAAISDRCMELGLSMNIVRLPHMGGVFRVAPPLTITDAESEKALEILDRAFSSVKGTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJX4</accession>
    <name>A0A1Y2BJX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_515547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJX4"/>
    <dbReference type="FunCoup" id="A0A1Y2BJX4">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJX4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJX4"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="32"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="233" mass="25706" checksum="71221F9D26BF9681" modified="2017-08-30" version="1">MSSPNPATTCLPASGSNANRAELPENALVLPPTTQLQALLTIIRDEKTQRGDFVFTSDRIIRLLVEEGLNHLPVVPKTVRTPVGLEYEGVTFQGRICGVSIMRAGEAMEAGLRDCCRSVRIGKILIQRDEETAQPKLFYAKLPDDISERYCLLLDPMLATGGSCIKAIEVLLSHGVKEERILFLNLIASPEGVNNVCTKFPKLRMITAWVDEGLDSRSYIIPGLGDFGDRYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKV0</accession>
    <name>A0A1Y2BKV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_509252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKV0"/>
    <dbReference type="InParanoid" id="A0A1Y2BKV0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="173" mass="18527" checksum="56EFFA87EF482F7D" modified="2017-08-30" version="1">MRPTPALVPALSFSHTFRPSTTSFCYTPTRPHQLGPTLFSAQQPNLLGLGIGLGRHQPNLLGLGLGRQQPNLLGSGIGLGRQQPNQLGLGLGLGRQQPNQLGSGVAQQSNTLPAAPPTDGLGFPVEGTWSSVEEEGWSSYGYGHVYGALPSTQYHTRPNSFPHNPLNIQRYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKW6</accession>
    <name>A0A1Y2BKW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_509555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKW6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKW6"/>
    <dbReference type="InParanoid" id="A0A1Y2BKW6"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="911"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="987" mass="105768" checksum="55AC76E2B4F30EF5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKX0</accession>
    <name>A0A1Y2BKX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_509536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKX0"/>
    <dbReference type="FunCoup" id="A0A1Y2BKX0">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKX0"/>
    <dbReference type="InParanoid" id="A0A1Y2BKX0"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="8"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="273" mass="31057" checksum="EF8B4C9F1C35CFAC" modified="2017-08-30" version="1">MSEQLLALDCDSLSFAYNEHTESILSDVNLKLERGSRCLLVGANGAGKSTLLRILAGKRLTKTRSCRILGQDVFMNPPGGVVYLGTEWSNNPVVRSDIIVSDFLDSVGGYRHKVRRDRLLSILDVDLDWHMHQISDGERRRVQLCMGLMTEWDFLLLDEVTVDLDVLVRKDLIDFLVGESENRGATIVYATHIFDGLATFPTHICHLQLGTTPRPTLVWTSSTSEDLFSLALSWLREDRELRREKEKAQGRVRGPRTDTRDAKTFFEKYDYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLI9</accession>
    <name>A0A1Y2BLI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_511223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLI9"/>
    <dbReference type="FunCoup" id="A0A1Y2BLI9">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLI9"/>
    <dbReference type="InParanoid" id="A0A1Y2BLI9"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="309" mass="34057" checksum="0CFE44BD01C05E1D" modified="2017-08-30" version="1">MPNSSSPPVLYTFPEVPQLQNSLANFILKAQTDAIAKRGSFTIALSGGSLPNNLKPLVGLEGIQWDKWQVFFADERIVPLDHEDSNYAACAKAFLDHVPIPREQVHAINTELFAESTLKDPTADPADQDASENEAIEIADEYEKQLVTCFASQGNAARYPTFDLILLGMGPDGHTCSLFPGHALLSDSDRWVAEILDSPKPPKRRITFTYQVLNHAFRCAFVAAGEGKQDTLSKILDQPEEGLPCSRVRPASPGLVFWFVDDAAAAKVKYPKTVFKWINETEMDASDDLVSEERKKMKTEMDAAVKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADT6</accession>
    <name>A0A1Y2ADT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase superfamily domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_554940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000127">
        <property type="protein sequence ID" value="ORY20713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADT6"/>
    <dbReference type="InParanoid" id="A0A1Y2ADT6"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="132"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY20713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="406" mass="45629" checksum="62457DA969C09673" modified="2017-08-30" version="1">MPTWRRLCRFKLQRSKMAVRKQHSTVSSPRSSISSQSKRPAHWVNDKGTAFVNPWDSYKVPAFWPLFKFVRQVGKEQRDDPDFERANELVPQVKPDFGINEPTTKLKATWLGHACFLVELPAPKEGGRGITFLLDPAFSHQCFPIQSTWLGPKGRYTPVPCSVTELPEIDAIVISHNHYDHMDLFTLKDLYARSPSRPPTLFIPLRNTATLQSTLPSSAKIIEMDWWDESEFVVEGKGSAKVICTPAQHTCSRIGIDRDKALWSSWALQSITSTGQKGASAWFGGDTGYSYVDKDIHTIDPSYPICPAFTEIGERAGPFTLGLIPIGAYAPRHLMSPAHNAPIDAVRMFKDVKCKQAIAMHWGTWRMALDRIAEPPLKLEEARKEVGMSENEFSVCAIGETRAYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF73</accession>
    <name>A0A1Y2AF73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_554087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000116">
        <property type="protein sequence ID" value="ORY21221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF73"/>
    <dbReference type="InParanoid" id="A0A1Y2AF73"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="332" mass="37209" checksum="1077EDACF10CBF27" modified="2017-08-30" version="1">MTHPIRRSSRQGVLTSDHNDDHESLSTISTGITSYILGDLRREANARMDERERRNALKDFDSTPTSEWDWGPDLPRGQERVEGTEIRNFRSHYRAYQQARILEDEPDMAVPQRDRIHWFDSDSSTDFSDTVRGGNTGVLVDEQSSSPELSESETVRENYCVAFPTPALGGAGSLPIFSSSSNDNDHDPFHILPGFHAITSFSPYTNSANMITRPHEIDCDLPSSPLEGRFGTKSTSAMLTCRNDARHTEIDEDLDYQQQIRLKTSPSPSPLVSLGQDSRPYGDGNEEETGDGGNSITTPDFSRQVLRDIRRIPLSSGRRVRVRNGILKLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFS5</accession>
    <name>A0A1Y2AFS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_553955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000114">
        <property type="protein sequence ID" value="ORY21294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFS5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFS5"/>
    <dbReference type="InParanoid" id="A0A1Y2AFS5"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="390" mass="40861" checksum="BD11A9CA78739F3A" modified="2017-08-30" version="1">MDNPLIETLAPPPLIADETPSTEFSSTFDSPDLDASSSIDQALEPLSDLSLTLNDVHADPILANLAKQQLKLNHTAETPEQIKSSQGRPKEGGKVGFRAKPAPASTHKSAESVGPKMTKAAMLRAGLEWTEPIRKSLDGTTGFDNVAGHKRVGLNFNIASLALPKVAPRTTKSSQLRTGQGQGQSGTDSPIKKDIAVVAAENKARDLAERDRRRKSVALPASLSAPQIAPRGNRSSALRLGTGTVVSPFRSPVTKSALTVTSASNVDKTKDKTAVTNDKAKDISIGTKDKGVVNRRASVIGAIRSLGAPSIMPRTNKSAMLRAPGPHVKSASISQPIAPPSLASPKPDLRRTEQTISSAGSVVQSSGPRPTKASLLRAGLGAKVAESQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI37</accession>
    <name>A0A1Y2AI37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_487968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI37"/>
    <dbReference type="STRING" id="71784.A0A1Y2AI37"/>
    <dbReference type="InParanoid" id="A0A1Y2AI37"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013073287" evidence="6">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="7">
        <location>
            <begin position="109"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="8">
        <location>
            <begin position="470"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY22176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="528" mass="57936" checksum="943B130427885A66" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIC6</accession>
    <name>A0A1Y2AIC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_551869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000096">
        <property type="protein sequence ID" value="ORY22232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIC6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AIC6"/>
    <dbReference type="InParanoid" id="A0A1Y2AIC6"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011813446" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="193"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY22232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="388" mass="43161" checksum="38F1E664228ED587" modified="2017-08-30" version="1">MMYTLAVLLWSLLATTSAHQVHQHASTATLNHPESTILEALSTYNDPVQAMVALHPSSADMLAEPRLLEVMDGSEVRWMTEGDKLRLRREDIDFIDWTRRDLLVERGFQADPNMPKVSHQAQVRKVFPHLSTTNMFEFLETFTAYYNRLYTSKTGVESQRWLYDEILDIIRKAPSTCRLSVEQIPHLFPQNSIIARFSPSGPRNISQTVTIIGSHLDSVNQYFPLLNAPGADDDGSGTATILEAFRSLVQVGYSPVDGPVEFHWWAGEEAGLLGSMDVAEDYKARGLNVGAVLNVDETAFIKVNSTPAINLIEVGATEKLNKWVHDLAKEYVDIGVKYSGMVGRGLDHQAWTRHGYSAVSIVEGDQAEGGWLPFPHTGASFTARNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIL3</accession>
    <name>A0A1Y2AIL3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nuclear encoded protein required for translation of COX1 mRNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_552294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000099">
        <property type="protein sequence ID" value="ORY22017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIL3"/>
    <dbReference type="FunCoup" id="A0A1Y2AIL3">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AIL3"/>
    <dbReference type="InParanoid" id="A0A1Y2AIL3"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="1">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="2">
        <location>
            <begin position="247"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="534" mass="60511" checksum="53DB0F9B9B2B13E0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIU4</accession>
    <name>A0A1Y2AIU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_552760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000103">
        <property type="protein sequence ID" value="ORY21855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIU4"/>
    <dbReference type="InParanoid" id="A0A1Y2AIU4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="235" mass="25577" checksum="F2B4990987DA7472" modified="2017-08-30" version="1">MSTGASTSQAKGKQSPAPRKTQKVTLPDGETLSCLLDYPADRIISSAEFTRLRQWPANLGPQVEGDVSLTVIQIAKPPEAKNSPDSSHATTQLSGGTSWFIPSEQHTATVENASLHITDTFRQVERQASFRLSSENLSENLTWTSPVLRRLTVTGDDTQSGAILKSGGKSYGPFDIEETVQVIGLPKTDQQRKGMTKETKKTTTPRTSKKPLVRFGKGLLSSRPILITTTKPLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJD1</accession>
    <name>A0A1Y2AJD1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_551197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000090">
        <property type="protein sequence ID" value="ORY22626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJD1"/>
    <dbReference type="InParanoid" id="A0A1Y2AJD1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="64" mass="7157" checksum="F3B1515E1568A61C" modified="2017-08-30" version="1">MLISFTNPKHATLFPFLLFGSPCAHYYSVLCFVPFVATFAVFPKKGSRQLGCKGLKTLCHCHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJN0</accession>
    <name>A0A1Y2AJN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_551441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJN0"/>
    <dbReference type="FunCoup" id="A0A1Y2AJN0">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJN0"/>
    <dbReference type="InParanoid" id="A0A1Y2AJN0"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000398">
        <property type="entry name" value="Calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY22500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="149" mass="16559" checksum="F52516D2A577B6FF" modified="2017-08-30" version="1">MAEALTREQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMIAEVDADGNASIDFAEFITLMARKMADTDTEEEIKEAFKVFDKDGNGYISSAELKHVMTNLGEKLSDAEISEMIREADKDGDGMIDYNEFVTMMMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKL2</accession>
    <name>A0A1Y2AKL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_551420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKL2"/>
    <dbReference type="FunCoup" id="A0A1Y2AKL2">
        <property type="interactions" value="1015"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKL2"/>
    <dbReference type="InParanoid" id="A0A1Y2AKL2"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="58676" checksum="1ECA3A641B06EE8E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMG8</accession>
    <name>A0A1Y2AMG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette, sub-family B, member 6, isoform CRA_f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_473180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMG8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMG8"/>
    <dbReference type="InParanoid" id="A0A1Y2AMG8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF648">
        <property type="entry name" value="ABC-TYPE TRANSPORTER ATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="160"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY23417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="391" mass="43575" checksum="106972C5AA649F56" modified="2017-08-30" version="1">MTQWRVATRRILVEKDVKQRGIVSDVLTNWESVKYFTAEHRELTRYKESILSYQDTEAKWQISYQLLFLIQTFLLSFGLMAGSLIIAFRALRGEADAAQFIVFTQYFMQLSGPLDRLGWLYRQLSQNATDAEKMFALLAQKTEVNDHPDAKDLVVTDGIIEFDNVNFSYDGEVQALKGVSFKIGKGQSMALVGESGSGKSTILRLLYRFYDITSGRILIDGQDISKVTQLSLRRAIGIVPQDSVLWNDTIGANISYGKEGATDEEVITAATAARLHDRILSFPEEYATIVGERGVRLSGGEKQRVSLARMFLKSPAILVLDEATSALDTETEREIQKALAELAKGRSSLSIAHRLSTIINSDQIVVMKDGSVIENGTYKELLELDGAFASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMN0</accession>
    <name>A0A1Y2AMN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_600798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMN0"/>
    <dbReference type="InParanoid" id="A0A1Y2AMN0"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="32"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY23550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="469" mass="50354" checksum="C975511F4D55086D" modified="2017-08-30" version="1">MAEQAPTSVDTEATPLLGKQVQKKATPLPKLQLAIICLIRIVEPICFQVIFPFINEMLVKIGAAKDRDSVGYPAGIIESIFSLTQLVTVFFWGSLSDRIGRKPVLIIGCVGSSVSAVAFGLSKSFPMLVLTRCLNGVMNGNIGVLKAIMAEICDETNEAKAFSFFPLCLNIGVLIASFIGGTFSSSERFPALHRIPLFAAYPYLLPNLLAAILPLVAAILAAIYLKETLPPPIHHNKSQPPSSPASSTTLDADAQVDEVEDSTSLWNLFTPEINALMFSFAVLSLLGGAVMAILPLFCFTPIADGGLDFSDGEIGTAMAVRAVATIIVQLSAFPWLQRRLGSLRLYRGLMVLWIPAYIGLPMLNGFARLGQKRVVWTGMVMTLLCGAIANMAFVCNLIMTNAAAPNRHMLGAINGYAQVLSSGVRIIGPGGASILFALSINHHILGGYFVWLVFGLVGVNTYLISVEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANI1</accession>
    <name>A0A1Y2ANI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine hydrolase FSH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_472661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANI1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANI1"/>
    <dbReference type="InParanoid" id="A0A1Y2ANI1"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="273" mass="29988" checksum="BBA351A45476861B" modified="2017-08-30" version="1">MPIRVLALCGFTQNATIYFKQLGAIRKACKDVEFVFLEPPIIVEQADMPWNQNLSEFDSSATTEKAEQTPETTPRAWWTTNGDRTIYRLWLKLPGKGFDETVQYIHDYLVKSEPFDGIMGFSQGACMAAILGALLTKPGLHPLFPSEPPLRAPKFIISTGGFLPTPSEPSFSEYFPLPSTLPILHIIGRNDTLITEEKTRTLINVCPNSRVEFHEGGHFTPSKANWRKFLNAYITSFAEGGSQGDVPSPSAFGPSGTTTPATSTPRAGSPHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANQ0</accession>
    <name>A0A1Y2ANQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_547490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANQ0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANQ0"/>
    <dbReference type="InParanoid" id="A0A1Y2ANQ0"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF8">
        <property type="entry name" value="FLAVONOL 3-O-GLUCOSYLTRANSFERASE UGT89B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="524" mass="57442" checksum="ADBC6C4B5AC5005E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP74</accession>
    <name>A0A1Y2AP74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP74"/>
    <dbReference type="STRING" id="71784.A0A1Y2AP74"/>
    <dbReference type="InParanoid" id="A0A1Y2AP74"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="210" mass="22889" checksum="BDDF0A82864E4269" modified="2017-08-30" version="1">MSRTTSFKLVLLGESAVGKSSLVLRFVRSRLSDERALADVVAAAFLTQTVKLDETTNIKFEIWDTTKDCVVADTYVGAGYKSLAPIYFRNSNAAVIVYDITQTSFEKAKSWVRELQRQADPSTIIMLVGNKLDLASARKTTTELGQRFAEEEGLLFAEASAKTGEGVQELFMEIAKKLPLAPPPQRSTQGGKNGVKVQGQTTEIPSACSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APG6</accession>
    <name>A0A1Y2APG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme-degrading domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_561613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APG6"/>
    <dbReference type="FunCoup" id="A0A1Y2APG6">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2APG6"/>
    <dbReference type="InParanoid" id="A0A1Y2APG6"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20026" checksum="2C3D6A42C14165AF" modified="2017-08-30" version="1">MSTTNHPLASLGKVTDFTIEQNDQIASLVAEQESLARLSAFNYETAWTIGNTIRSLFLERYDPKKNGVSVKIETSTGHVLFSASVGDAPGVMLGNWSWVEGKAKVVRRMGKSSLRVGRELASKGREPESQGLYWPEFVCHGGAFPIFVKGVDVGPIGAIMVSGLAQLEDHQLIVDALVKSSHLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ73</accession>
    <name>A0A1Y2AQ73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_323368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ73"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ73"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="549" mass="60195" checksum="E542DFC8FBAF7848" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQC0</accession>
    <name>A0A1Y2AQC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_590445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQC0"/>
    <dbReference type="InParanoid" id="A0A1Y2AQC0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="188" mass="21471" checksum="4A3F242232AD57BC" modified="2017-08-30" version="1">MADTASVAWIATNPLETPSGNAQSKSTRQRPQTPRAPRRLDSSLLPDHEAQSPIRQSASSISHKYSYFLDRSKIIQFNVDLSMNLSEEVEEEGEQEQEEEEEEEEEEEEEEGEEELLEEKEEENPNSNIKSVGNQGSKSGVQQHTIKSRPEPQRRMIVLSNSQIRQKRRERRSIRAHPYLKKSGSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQI9</accession>
    <name>A0A1Y2AQI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_507555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQI9"/>
    <dbReference type="FunCoup" id="A0A1Y2AQI9">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQI9"/>
    <dbReference type="InParanoid" id="A0A1Y2AQI9"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY24215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="123" mass="14296" checksum="FBDE4A87D315E9B5" modified="2017-08-30" version="1">MVRSKFKDEHPFDKRKAEAERIRQKYPDRIPVICEKAEKSDIPTIDKKKYLVPADLTVGQFVYVIRKRIKLAPEKAIFIFVDDILPPTAALMSSIYDEHKDEDGFLYVLYASENTFGQLESLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQN7</accession>
    <name>A0A1Y2AQN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase Rpb7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_545580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQN7"/>
    <dbReference type="FunCoup" id="A0A1Y2AQN7">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQN7"/>
    <dbReference type="InParanoid" id="A0A1Y2AQN7"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="172" mass="19343" checksum="F26BA8D87E0041B1" modified="2017-08-30" version="1">MFFLRQLNHTILLHPSYFGAQLEDYLRQKLYEDVEGTCSGKHGYIIAVIKIDSIGEGKVLPSTGQARFRTTYTAVVMKPFKGEVVDGRVVNVNKMGFFAMVGPLQVFVSSHLVHADMKFDPNASPPCYRSNDEIIQKDSKVRIQIVGCRVEANDIFAIGTIKKDFLGQIRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR03</accession>
    <name>A0A1Y2AR03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_507323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR03"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR03"/>
    <dbReference type="InParanoid" id="A0A1Y2AR03"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="101" mass="11353" checksum="DA1E03FB7DA27EBE" modified="2017-08-30" version="1" fragment="single">MNRIFGSNKAKPKPSLTDAINSTDSRIGTIEVKIKKLDAELGAFKAQMAKLRDGPGKSAIQQRALRTLKQKKMYEGQLMQLQQQTWNMEQAAMTTENLKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR61</accession>
    <name>A0A1Y2AR61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress responsive A/B barrel domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_546618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR61"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR61"/>
    <dbReference type="InParanoid" id="A0A1Y2AR61"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="111" mass="12722" checksum="5BF394DA42A132F8" modified="2017-08-30" version="1">MTVHHVVAFKLNPLSHMSTLIAGMFDLQTSCTKNGVPYIKSIKGGKQMSTERHHQDMHVTFIMEFESNEDLQYYLWKDEAHQSFKHILNNDLGKAGVICLDFEDGLFHEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASH4</accession>
    <name>A0A1Y2ASH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_544785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASH4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASH4"/>
    <dbReference type="InParanoid" id="A0A1Y2ASH4"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="644"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="818" mass="87616" checksum="9E3BB2C19649EB0D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AST0</accession>
    <name>A0A1Y2AST0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_560937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AST0"/>
    <dbReference type="InParanoid" id="A0A1Y2AST0"/>
    <dbReference type="OrthoDB" id="3918888at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="161" mass="17743" checksum="CCFAAD4D4B02084C" modified="2017-08-30" version="1">MSSVNVESAVDGDQAKMELRRPPVTPEQTEEIERPRHVIAGENEWNRLLLLLRVLALIFLCFACFLFTRFVLHNGWTSLIDKASSDRSPRSACLTMDEANLCTTWVNYDSRYLPNGASADLANFSMSCAKNGGRSEFKDLTTDDGVVFICVSGRASGASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATG1</accession>
    <name>A0A1Y2ATG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase ESCO acetyl-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_589986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATG1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATG1"/>
    <dbReference type="InParanoid" id="A0A1Y2ATG1"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="2">
        <location>
            <begin position="358"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="430" mass="46820" checksum="079DDAE6311152DB" modified="2017-08-30" version="1">MSDRPLVRRTYGKSRPLMSSSSSSMLFHDDSTPSSSSHHVRSSSPPSSDPLLTPPPSSPPSSAARLYEGTINENHEQQQHRPFALNTKSALTNSSKSLMSTQSTLKGFFVSQKRRRPLEPTTILDPTLSPSSPRKPKASSASSLPKHTLSLPPKNTLQQTHLTHLPLLHTCQECQMSYVRASDDEGLHARHHARVVRGIVWDQGVRPKANKGKEREAGWRVVSDNIQLGPRDSAKGRIIVCDASWGGHNKLSEILSTVDTVLSSPPLPSSILSTCKIFLFLTASPPPSSSAKRPRPLPRGLADPKDSKRQAKERVVAVVVAQPIKWAMRVLKPAETIQQVVDSGGGVLCDPTPLDTPLGIHRLFTVPAYRSLGLARLLLDASCRETVYGCVFQPGKGQVAFSQPTDSGRKVMESWGGGAIRVFVDDESQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU01</accession>
    <name>A0A1Y2AU01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_272747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU01"/>
    <dbReference type="STRING" id="71784.A0A1Y2AU01"/>
    <dbReference type="InParanoid" id="A0A1Y2AU01"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="347" mass="37401" checksum="7321F328BAE8835B" modified="2017-08-30" version="1">MVNANGNGTQETNVVLITGAAGWLGNILAGELLSDPLTPNVHLILADIVEPKPPKGATQVVTRKADLTNKDEIDALFHIEFGVPDTVYCFHGIMSRGSEDNFDLGLRVNIDSIRMMLEAARQSRPVSGQPVKFIFTSSLAVYGGPLPDVVNIQTIATPEGAYGMGKLSSELLVNEYSRRGFVDGRILRLPTIVVRPGVPSAATSAFISGIIREPLHGVEAICPVGNGHDSPELNLAAWVASPETTIKNFVIAKHVPVEKFLPHTRVAYLPGFTTTVREELEALATVAGTDVLKLITFKDDPINRRIVGSWPARFDNAYPLSLGFVVDEGGMVPVVQRFKEMVEAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW00</accession>
    <name>A0A1Y2AW00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_589488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW00"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW00"/>
    <dbReference type="InParanoid" id="A0A1Y2AW00"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="784" mass="86029" checksum="C1096AF264C29239" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW06</accession>
    <name>A0A1Y2AW06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_540383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW06"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW06"/>
    <dbReference type="InParanoid" id="A0A1Y2AW06"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="110" mass="12612" checksum="F97BA831897BF568" modified="2017-08-30" version="1">MTSRLPGGPRLTLQHFVLQSEFIHAYRSAVRATRPLPDSSTRRETLDWLRSDLERLRSIHDLDALNTNLSHFNRTVKIMLPQLGLSGLDEKRGAKLVGQRREAWQRALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWM1</accession>
    <name>A0A1Y2AWM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD binding domain of 6-phosphogluconate dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_539613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWM1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWM1"/>
    <dbReference type="InParanoid" id="A0A1Y2AWM1"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="314" mass="33721" checksum="3F5D484E5DDC137E" modified="2017-08-30" version="1">MSEPFRIGYVGLGNMGTHMCNNLGRYASQNQLSPLTIWNRSTDKYASVSEDCKGAHLAHQVSEVPEKSNIIFTCLLNDAAALDVYGQMLKVVKAKTIFVDQSSLNPKTSRKLREDAEKVGATYLSCPVFGPPAVAKAAQLVLVVSGAEEGRDRVKPLLVPAVGKSIIDVGEDVGKGASLKLLGNTCILGTIELLSEAYALADSIDFDPAVFQNFIQQWFPAPAWKNYGTKISKGTFSGTNGFRIDGGLKDANHILSLGQDMGHPCPVPTIERAVKNLNRAKEIGGPGMDWSSLAIAQRESVGLEPFRPGSDQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXJ9</accession>
    <name>A0A1Y2AXJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXJ9"/>
    <dbReference type="InParanoid" id="A0A1Y2AXJ9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="254" mass="26009" checksum="9CC1ED30C3DCB84F" modified="2017-08-30" version="1">MPYLSTSGQSNSGGVDEESTRMTVGWLRTSRACDTAVAACFSLVASVASNTEKCVDTVGKAATALGKVLDSVGTVASVCGEWVQTMSPKERSTQAGTNAAQANGLQERAPTPSLNALQELLDGLGSSPYSEPRSLTAGPQSQISRGNVSSIGSPRQWRLLDNGVSPSGGGSRGQVSDTCVQSVSGVGFVQAWAASVPDHLSVREGTSELGDSSASGSQDPDGRTSTIGSVDTSHRLSITSVMDLMMDCLAANTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXL6</accession>
    <name>A0A1Y2AXL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_560061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXL6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXL6"/>
    <dbReference type="InParanoid" id="A0A1Y2AXL6"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="571" mass="61183" checksum="92335A2877B170C4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXP7</accession>
    <name>A0A1Y2AXP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_538422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXP7"/>
    <dbReference type="FunCoup" id="A0A1Y2AXP7">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXP7"/>
    <dbReference type="InParanoid" id="A0A1Y2AXP7"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="120" mass="13162" checksum="536A74A06D5629CF" modified="2017-08-30" version="1">MSQNQPSTSKTLQSSLNSLISNYANTTPPRIKLVDSFLLFLLLSGVLQFAYRILITSFPYNAFLGGFGSTVGQFVLLAGLRAQVSPGRDVEFKEVSQERAFADFCAASIVLHLFAYNFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY07</accession>
    <name>A0A1Y2AY07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_538163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY07"/>
    <dbReference type="FunCoup" id="A0A1Y2AY07">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AY07"/>
    <dbReference type="InParanoid" id="A0A1Y2AY07"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="239"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="644"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="698"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="877"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="936"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="975"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1140"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="975"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1076"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY27469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1172" mass="126823" checksum="95EA7BAB38106721" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY13</accession>
    <name>A0A1Y2AY13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_538216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY13"/>
    <dbReference type="InParanoid" id="A0A1Y2AY13"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="74" mass="8117" checksum="1E495A97DB0F53FE" modified="2017-08-30" version="1">MIYHIRRDETLVKVCFSFFFSSLLHFSLSPSLSFTGVLTVTPRVFPAPTYTPPPMLSLTGAVCLKPPSLLSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYR5</accession>
    <name>A0A1Y2AYR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_538039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYR5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYR5"/>
    <dbReference type="InParanoid" id="A0A1Y2AYR5"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28482" checksum="CF17E8B6DCE4A928" modified="2017-08-30" version="1">MSAADEWKPAAPELSDDLIAELEKPGNEKKWRTMQFDARETKNYLETIRPKVKPIDSFWLIALTSHRVISPLISSKSDQHALSFVEHVELVQDEEDPRPYEIIFHFKENPYFTNSTLSKKFSLKDEFKDKKDGFEDDHLEPGIQKIDWKEGQNLTEKYPRQSGEDGDFEGDIGSFFHFFTEAEDIYGIGQLLQDEILPEAVGFFTGKEGQDEMNSEDEDEESGDEEDEIDLEDEEDDQPKKKRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYZ9</accession>
    <name>A0A1Y2AYZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_539144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYZ9"/>
    <dbReference type="InParanoid" id="A0A1Y2AYZ9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="207" mass="22406" checksum="6990A3CB14D055C3" modified="2017-08-30" version="1">MMPTELYRHNDPNLFGDNPTGTGTNGPEMTERIQFPSSATSATGDRGSPYDYMGDQSLFQCSGDSLFGSLASLRQYPVMDSNRLPATTHAGNPASGDDFFGSLDLLRQYPAMGSMGSNLLPHSDATTHAGMPTHHHRPPPIPSPAPHTASRHRRSPYDNNALLAGHYGPSSYPSPISAPSRDDAQQTMDSSRNKIDIYTLNPNQTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZB7</accession>
    <name>A0A1Y2AZB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_537558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZB7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZB7"/>
    <dbReference type="InParanoid" id="A0A1Y2AZB7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="333" mass="35594" checksum="E6549847BA69F466" modified="2017-08-30" version="1">MTITEAFTDFETATQTELLTDILTMFETATLPITVPITEISTQSVIETMTMTVNETITIPTTIVSTVLMTVTQTQEIPTTVLLTETAFQTEIMTEIQNQTLLETQTQIETSIEQMTQSVTEILTATETELQTIINTSTEIDTATQLLTGTETETATATESDIITATLTLFNISTAIYTQMDPTTLFDTATDTIVETATATATETETAISKETATVVETATSIDTATATETETAMATETATETATETATETATETKTETDTETATATETIDPLASCSASCSSQFVYLSTPTPTPTTQVQDCTSGECVSRGGRGRGRGGAGEGEGYYRPRHVGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZZ1</accession>
    <name>A0A1Y2AZZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_446914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZZ1"/>
    <dbReference type="FunCoup" id="A0A1Y2AZZ1">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZZ1"/>
    <dbReference type="InParanoid" id="A0A1Y2AZZ1"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="260" mass="28377" checksum="1291075634067E56" modified="2017-08-30" version="1" fragment="single">IYREWLLSSLASYPDSSISSNIELILDGYDVVEKGEFPPQSRLVAGAAEGYDVVMMTGSKHTAHDSSIPFIKPLVDFISGVAHNPATQHVRIVGVCFGHQIISLAMGGQVVAGQNGWEIGVYGNDVTEEGRYWWCGDVKGEGGGEKVFIEQMHRDHVPSLPPGFHLLLSTPNYPVHSMIRYHPASTSSNPLAQILTVQGHPEFTPSIVSKMVDFRSQQGIFDPPTAQEARRRLGGKDGSGGEGFGRVGWAIWRVLLQDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B066</accession>
    <name>A0A1Y2B066_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_535563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B066"/>
    <dbReference type="STRING" id="71784.A0A1Y2B066"/>
    <dbReference type="InParanoid" id="A0A1Y2B066"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="258" mass="28723" checksum="8CD4BAF00076C697" modified="2017-08-30" version="1">MFSGLYEPLRESLDAFHQLEHIFPINSKTLSKDADQVKRNLAELIQIVQNLATRKGRKRSREEIGGEGREEELRRLDWLDGEGVRLWNLAVSGAAKTAAQDDEIEDREATALPAAQINSIDELLVTGSRQKLPSPETRLGAQRQMDELLAFSLARIDVALAHGKVDSAFTFIRTALEWNGEGGFGPQHLETLLSKCWTVGDQLRTEAKDGKSDLLAEAVTWLQMAAQIVEIMELRVGMNGLNSELKVAVFRSLRVCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0C1</accession>
    <name>A0A1Y2B0C1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Triose-phosphate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_535323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0C1"/>
    <dbReference type="FunCoup" id="A0A1Y2B0C1">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0C1"/>
    <dbReference type="InParanoid" id="A0A1Y2B0C1"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="119"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="573" mass="63329" checksum="9AA938D5D6B76F7D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1H0</accession>
    <name>A0A1Y2B1H0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_535520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1H0"/>
    <dbReference type="FunCoup" id="A0A1Y2B1H0">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1H0"/>
    <dbReference type="InParanoid" id="A0A1Y2B1H0"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="644"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="691"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY28327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="833" mass="89490" checksum="4D01D6FD8F1E003A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1Q7</accession>
    <name>A0A1Y2B1Q7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plectin/S10 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_533692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1Q7"/>
    <dbReference type="FunCoup" id="A0A1Y2B1Q7">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1Q7"/>
    <dbReference type="InParanoid" id="A0A1Y2B1Q7"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="155" mass="17445" checksum="1882C867E2395528" modified="2017-08-30" version="1">MIISKQNRRVIYENLFKEGVLVAPKDFNRPAHPDIPTVRNLEVIKAMQSLTSKGYVKTQFSWQYYYYVLTDEGLSYLREWLHLPAEIVPQTHMKPARPAGRPAGYGGRTGGDGAYRPPRGDREYRRRDDAGEGKEGASAEYKPRFGGVGRGAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B272</accession>
    <name>A0A1Y2B272_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-galactose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_575591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B272"/>
    <dbReference type="STRING" id="71784.A0A1Y2B272"/>
    <dbReference type="InParanoid" id="A0A1Y2B272"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="297" mass="31230" checksum="89BE562062817752" modified="2017-08-30" version="1">MHVLVTGASGHIGKAVTASLLSRGHTVLALIRSVSSEKLYRARFPNEQTVQIASGTTAELDKLARFAATADAVIHLANITDPSISRDQAAAMDENIIRALARGLATAASTHKAFAIASGTGFTLPEDTSKAGQGINRLRLESDIPTGEGFNGIAVRISPTAHGKDDAGFVAQFISAARKNGVSLYVSEGENRWSAVHVLDVAELFVLAIESSPNATVLHGTGETEIKFKSLAEAIGQGVGVPVKSETDEIVLQSHFGRLAALVGLDIPVSNERTLSSTGWVPRHVGLIEGLTEDAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B290</accession>
    <name>A0A1Y2B290_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_495738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B290"/>
    <dbReference type="InParanoid" id="A0A1Y2B290"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="499" mass="54459" checksum="19C10D5294558731" modified="2017-08-30" version="1">MSEHIELAETEPRVTSISEQKETHQETDAEAGVQGKAALMKAERRLVRKLDIAILPFSVLLYLSAYLDRGNVANARLQGMERDVLRGSDSNYSLALATFFIAYIVCSIPGTLMAKQFNPSRTIAVGAMIWSVAATLQAAAFNPAGFFVARFFVGVGESMFGQAMGFHLSLWYTKGDLAKRVGLFISSGALAGAFGGLIAFGISSVERTSIKQWQILFLIEGVPSVILATATWFFMPNRPESTRYLNEEERELCLRRLGRSISVESQPGIAWKGVIRCVKDWKVYLMAVMYSCMNLTLASVGGFLPTIVKGFGYSNAQAQLLTVPPYAVALVFMLCLTAFSDWKQARGFPVVAVFILGIVGWAILLAVPAAGASHAQYSVRYFGCCLITTAAYTNIPLIISWQAANNPNESQRATALGYLNSIGQGLSLAAAFLFPSVEGPQYIKGSIINIAFQALGLVIALTLTAFCRWENRRRDREEGGRPEQGASLDTYDKFDYAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B376</accession>
    <name>A0A1Y2B376_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-oxoadipate dioxygenase/decarboxylase</fullName>
            <ecNumber evidence="6">1.13.11.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-hydroxyglutarate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_183887</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.93" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B376"/>
    <dbReference type="STRING" id="71784.A0A1Y2B376"/>
    <dbReference type="InParanoid" id="A0A1Y2B376"/>
    <dbReference type="OrthoDB" id="8300246at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.80">
        <property type="entry name" value="Uncharacterised protein PF07063, DUF1338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="HGLS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047869">
        <property type="entry name" value="YdcJ_bac-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479:SF2">
        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="HGLS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="482" mass="54057" checksum="92445AB8ADDEC202" modified="2017-08-30" version="1">MTVGPMPSEFVDPDELRAEFCSALSKMYRSEVPLYGDLVELVDEINDRADEQESWQISDRLKVERHGAIRLGLPSELHTISRLFRLMGMYPVGYYDLSGCGVPVHATAFRPTTRSSLSKNPFRVFTSLLRPELIPDAKLRDQVLSILSKRDIFHPTTRALISQAETRGGLTRPETNLLVQHALETFKWHEEALVPAETYARMRAVHPLLADIAGFRGPHINHLTPRVLDIDAAQAGMPARGICPKAIIEGPPRRLCPILLRQTSFQALTEHIRFPGGGSEGSHRARFGEIESRGCALTKKGNLICLHPSNPLHSVPLVANQHVGHDLYLSLMAESQRTAPPNESNAAHQTLLHQIFTHRFPDTWTSLRQEGLAFFRYTLITPPQPLSNNTTLDELIDSGNIQAEPIVYEDFLPASAAGIFRSNLGQEQSEHVQKNIEAEEESTRKQFEIALGRPVEDFCDLYQAMESDSLQAVERTLGYRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3K5</accession>
    <name>A0A1Y2B3K5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_467592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3K5"/>
    <dbReference type="FunCoup" id="A0A1Y2B3K5">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3K5"/>
    <dbReference type="InParanoid" id="A0A1Y2B3K5"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="144"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="767" mass="86881" checksum="9C507D3D80C5EFCB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4C4</accession>
    <name>A0A1Y2B4C4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_531653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4C4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4C4"/>
    <dbReference type="InParanoid" id="A0A1Y2B4C4"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY29689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="230" mass="25787" checksum="8E473FFC2ED61349" modified="2017-08-30" version="1">MLASTSRAGFWQSTGLIQSSSFSSTARCPARRRVLVELLEDVANVGKKFDKELVKPGYARHYLVPLRKARLVAASPVQKYHPESLVDRILNAHRDVPFYDSDADPSLYIPAPRKSRKNQKTRAEEHDAQVSVLLADVPPVLEFALRTIAPNDPAVHGSVTLSDVAERLAVEHDLLPADFRVYWEDEAHGAEARIKELGTWVAVVEKKTGREEKRHIDIKVVRLKETQPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4K0</accession>
    <name>A0A1Y2B4K0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal peptide peptidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_530848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4K0"/>
    <dbReference type="FunCoup" id="A0A1Y2B4K0">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4K0"/>
    <dbReference type="InParanoid" id="A0A1Y2B4K0"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY29751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="433" mass="47584" checksum="BF448EAA59FE8360" modified="2017-08-30" version="1">MSSDTGLYTAYISLGAQALIPIILGSFQSLKTPASVLARRKKSKRRDNTLLLLGNDDDEDSELDDEIFEETLGWADSLVFPIFGSIALLGLWALLKYVGPEWINFVLGIYFSGAGMFAVQTTFSSIVTYILRISGQHTPTYHIRISSGIRQIFHLPISLPSLALVPLSIILPALYIPLGRPWLLSNLLALCLGTTTLAILRLDSFLTAFILLAVLLVYDIFWVFATPVMVTVAKGIDAPIKILAPKSHTSDFAMLGLGDIVIPGLVIALCLRFDLHRAALRYPKADLTPRSRFGKGYFLVALTSYIFGLGTTMVVMHYTRHAQPALLYLSPACTLGPIFLALARREFALLWGFSDAPIDIDEQVRDDTIEPPSEAAQRAREAIKDDNVAEVAKGVSEHVEVPTPPPVEEDDSWMNEPTEAGGKARKRKSGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B508</accession>
    <name>A0A1Y2B508_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_575262</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B508"/>
    <dbReference type="STRING" id="71784.A0A1Y2B508"/>
    <dbReference type="InParanoid" id="A0A1Y2B508"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="17">
        <location>
            <begin position="49"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="16">
        <location>
            <begin position="175"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY29175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="435" mass="49351" checksum="29227EF04CA82C9D" modified="2017-08-30" version="1">MLKRQLLRLESQPFRAVRPARHVIHHPPPCIQSRNVSYVQVKPVGLRTAIAWPNGVETTFDNQFLLDHCRCPKCFHPVTKQRLKSLFDFTPLVEPDAVEVDTKSVRIVWSDAHESRFPFSFLLRAAYDPPLAPREDEPDDRILWNSRISQSPPIVQYQSLMIEEVGEEKAELGILRWLRKVSDFGFCLVSDVPVSPQETQKVIERIATIRPTHYGGFWDFTANMSLGDLAYSSQALPAHTDTTYFTDPAGLQIFHLLSHPSPPGTGGSTLLVDAFYSASLLSQLDPTAYSVLSRLRVPAHASGTPGSLLRPVISQPTFRHDERGRLAQVRWNNEDRGVIGSRWTPGDVQSWYAAARRFEEICRNEDTEYWVQLRPGTLLVIDNWRVMHGRSAFTGDRRMCGAYIGADDWRSRKAALEARFVSKAAGEDDIWESGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5H0</accession>
    <name>A0A1Y2B5H0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FUN14 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_530373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5H0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5H0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5H0"/>
    <dbReference type="OrthoDB" id="163794at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF10">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="234" mass="25265" checksum="2706B9A0430C7A0D" modified="2017-08-30" version="1">MSIRTTFLPSILRSYRSSTSTTISSRAFHFLPSSPPPPSPKTTPFRSQLPFARQQPQIIAKTRAYPRRKSSQAQANSFLFALGIGATFVGISSLRTPPARSEPLSSSSGPRPEIGGGQPQPPAESILSVYQLSFGAVCGICTGVFVKKGLRAIAFLLGGVFILLQYLSTKRFITVDWSKVAGRYDTAFGTKTPTGEQRSPTVGGVWAWFVDFVTANFQQRATFLAGLALGIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5I2</accession>
    <name>A0A1Y2B5I2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_158289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5I2"/>
    <dbReference type="InParanoid" id="A0A1Y2B5I2"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="220" mass="23552" checksum="2B4AA7913BBF68E6" modified="2017-08-30" version="1">MSFLPTAKAQVSSCVLPCIKADLLHRCDGKRPECENCSRRGETCSYDDNVRRRGPGKRTKEMRERAAREAEAAGLVNDNSANTSGGLGDMDVGLAINASLAMETLGNEAGPSTLAEVDETGIRRGRKRKSEVPVDGDKRAKLEGEELSESDVHALQELEHLDESAFGSIDPALQHISESLAGAQSVAYHVDHGHGPSGYIHDQGNGNGDGVDQEHDHLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5I6</accession>
    <name>A0A1Y2B5I6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_163671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5I6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5I6"/>
    <dbReference type="InParanoid" id="A0A1Y2B5I6"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012305154" description="RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="35746" checksum="0A4CFAD9B2F563EF" modified="2017-08-30" version="1">MLVLTRLAVLVLPVLSLVSASHIRQQHNRHHNLKRNFEVVERDIELRDDQTPAPRSELNKRETYSGDGTYFYVGLGACGQTSVDSDLMVALNYQQYGDGYPGPQCFKYITIQANGITVSGVEILDECPSCPNVGDLDMSPGLFQKFVPGQSIAVVGEISIDWWFEDGSGSGSETTTSSTSKWVAPTSTWTPTSTSTWVAPTSTWTPPSSTSTWVAPSSTWTPPSSTSTWVAPSSTSSSSTWSAPSSSTSSWWSSSSSTASSTTSHNSTSSYNPYIKASSYAPSASASSSSNSTTSSGSSGTTDSSSTTTSTYSGNLEAFNGLVTNYGQLVVVAAGGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6N1</accession>
    <name>A0A1Y2B6N1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_495106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6N1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6N1"/>
    <dbReference type="InParanoid" id="A0A1Y2B6N1"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="562" mass="62130" checksum="FDEB87D4AC02D2A8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7G5</accession>
    <name>A0A1Y2B7G5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_528286</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7G5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7G5"/>
    <dbReference type="InParanoid" id="A0A1Y2B7G5"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010990125" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY30782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="481" mass="52614" checksum="2FEFE12BDA9C8BE5" modified="2017-08-30" version="1">MRAGVLSVAFLSLGVGSVVGSAIDLALAKGHDILEAASQLIVSEPIPPSSPLLEIDESYFDVESGTKRKLCVLHPKGGEELDDDNFKAAFEHCGNGGIIRLPDANYTIGSPLTTELNNAILDVHGWISFSSDIDHWVAKRVPFEFQNLALAWIIKGTNYVLEGNGKGGIYGNGDVWYNWAKDEGNKYGRPMSFAISDSKNVVVRNWSVIQPQFWASIVIRSENVLYKNYYVNATQYNPEASGHFLNWLQNTDGCDTYKSHNVTFEDMVYQGGDDCLALKPNSSMIRARNVTCFGGTGIAFGSIGQYKGIVDYIDDVEFTDITLLPSSQHLMKNGLYFKSWMGYEIGTPPNGGGGGSGYGRDIKVDGVKMKDVIRPIYLQSDLTYLNDHRGEGHDTGLFHWSNISLSNISGTSALNRVVWLDCSKQTPCKDITFDHVKITPGKDDAPEIHYVCNNVVLGGGDGLDACHPSDSQKEGAEEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B810</accession>
    <name>A0A1Y2B810_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_155452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B810"/>
    <dbReference type="InParanoid" id="A0A1Y2B810"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="240" mass="24791" checksum="F1ADE4D600FF4961" modified="2017-08-30" version="1">MVQGRRRRVGENVGHGHRQERSLGSVKPSMHTSPGASHIATSRLPLPLAIPIVSPHNSSSDFTLSSFFLALSFASSWGPNRNTPSSPPGFLSSNPQKDLSMGYSSALPGRRLGQGPKARKGGRGGFGGFDGGGGKGGGGEACCCRNPHGGFSGLAGGMPRCLKTGSPSISRMRGNGLAGRRIASSSALLSSSRSAFSRSFISSSSSESLADGSFSLRRRRLSFRSSNGEPIRTVLPSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8G5</accession>
    <name>A0A1Y2B8G5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_564913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8G5"/>
    <dbReference type="FunCoup" id="A0A1Y2B8G5">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8G5"/>
    <dbReference type="InParanoid" id="A0A1Y2B8G5"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="232" mass="25616" checksum="0A0D786E2B1103D1" modified="2017-08-30" version="1">MSRLMSDYEVTLINNKMSDFFVKFHGPAETPFAKGVWKIHVELPEQFPYKSPSIGFMNKIYHPNIDELSGSVCLDVINQTWSPMFELINIFEVFLPQLLRYPNPADPLNGEAAALLMRDPKAYAKKVETYVERFARPADADNAGEGSDDDEDDDEPMNGPKGRAASNGRLNGNGNGNGHTGNGNGNGHSSGNGHADEAEAEDDEEEDEDEDEKMSDMGELSDADEFMGEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8W8</accession>
    <name>A0A1Y2B8W8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_452500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8W8"/>
    <dbReference type="FunCoup" id="A0A1Y2B8W8">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8W8"/>
    <dbReference type="InParanoid" id="A0A1Y2B8W8"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY31301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="78" mass="8780" checksum="888338A6D8CA248D" modified="2017-08-30" version="1" fragment="single">AGNSRLAPLEQDVLWEYAKLNDKIRRIANLARLTADSPNEDLLSELRVLEKKMGLVLTLYKASVYAVMMDSQAEAETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8Y9</accession>
    <name>A0A1Y2B8Y9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8Y9"/>
    <dbReference type="InParanoid" id="A0A1Y2B8Y9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="420" mass="45625" checksum="55A1BE5376A7B14D" modified="2017-08-30" version="1">MSTVPPSKVEPPPYLAADMYDKPPTRLPQPSSRTNLRSVASTSGLIPATVGSQRPTVPSRPPTIPSRPSSAVPGSSRPKSNQSTAKPRPATALSSTAKQLGTQTQTKRDSTAIAINPSILRRQRSLPIRSAIQPNGQAMSSDRLTLPAPKPLAVKRILSSQNLNDANRPIATDVKSRPKLTTTSWGSRLIAQAPSRMGHHNPSAAMEHIEEETDDLWQTRPLDQTSKFTKPHNTFSLPLVADLSITSSSASPSTPYPAVKGKQRYKSTTQATLHPSASTRIRPVLVDTPQRPLPVRPKIIDPSPLMPRLASTWLAEPRESLEMMKDISMSFQDSSDDGSPFWLGNQSRSDPIACGVTQTSSPQLAPQANPSQGLIEELNQTRSRYEQAVETKDTAQTMARRAISKLVITKFDAVIRGKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B901</accession>
    <name>A0A1Y2B901_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_527480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B901"/>
    <dbReference type="FunCoup" id="A0A1Y2B901">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B901"/>
    <dbReference type="InParanoid" id="A0A1Y2B901"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001461">
        <property type="entry name" value="GTP-binding protein ryh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="226" mass="24816" checksum="63F93B390B698AEE" modified="2017-08-30" version="1">MAEELFNRTYSATSSAKPSSAVDTVMSSPGTPSPASPASQDYSSASNPLKKFKLVFLGEQSVGKTSLITRFMYDTFDNTYQATIGIDFLSKTMYLEDRTERFRSLIPSYIRDSSVAVIVYDITNRTSFLNTAKWVDDVRNERGQDVIIVLVGNKTDLNDKRQVTPEDLDKRAKELGVMSIETSAKAGHNVKALFKKIAMALPGGSADSKDGAANQSQSFSSFEECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B996</accession>
    <name>A0A1Y2B996_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRAPP II complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_526606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B996"/>
    <dbReference type="STRING" id="71784.A0A1Y2B996"/>
    <dbReference type="InParanoid" id="A0A1Y2B996"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="2">
        <location>
            <begin position="302"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="3">
        <location>
            <begin position="459"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="606" mass="67461" checksum="A22A6A5714ED3E03" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9A8</accession>
    <name>A0A1Y2B9A8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_526658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9A8"/>
    <dbReference type="InParanoid" id="A0A1Y2B9A8"/>
    <dbReference type="OrthoDB" id="2595615at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="126" mass="14202" checksum="413CD20A3EB318E5" modified="2017-08-30" version="1" fragment="single">MTSISPSKSQSTVPASEAAPRQSSWNISPTLTSRQVLPDRWTDGNVIPDGLVGKETDPSRMGIFLCLLDERPHLHPSLQALHKHRFQIHGIALPPDPARDMPGDNSWINWRFTEEEQARRKAYLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9H3</accession>
    <name>A0A1Y2B9H3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Raptor N-terminal caspase like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_465764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2B9H3">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9H3"/>
    <dbReference type="InParanoid" id="A0A1Y2B9H3"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="95"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1343"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="890"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="949"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1505" mass="165369" checksum="FE96834031DEDC4A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9J5</accession>
    <name>A0A1Y2B9J5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_90112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9J5"/>
    <dbReference type="InParanoid" id="A0A1Y2B9J5"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY31366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="392" mass="42839" checksum="AE8D1DB145889287" modified="2017-08-30" version="1">MSTKTRRPVALATPPRKVISRYTQAEKESLLDNYDLEVADKTRAFHIQLGVSLQAFLLRQETELMRLPRELRGMTLSDLEDKWGGSWSGTVQRIARERMEREEGARRRAEEEAAAVAAAEEENDDVVKGKRKRGTGATIQSPERKKNARRDSAQTPSTNRSKSSKARKPRSKASQTPSKGPSTLPQNHIFNPILPPITPGYARQARMNEITFSANGSPIVLPPNKGQGTATNTNTSKSKSKGIGIGAVSPISPSRPLPPLPALSDSDSDSELDLPDPAELEAKLLARQSTSTASQPSRKPKRAPSIIFRHAPLAPIPAPAPTPSASTEPISTIPLSDGRTIAFNPLQMDPKVIDEELEQGGLSGEEKELVRKKVREEVVHRLAGMMELWKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB25</accession>
    <name>A0A1Y2BB25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_597878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY32013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB25"/>
    <dbReference type="InParanoid" id="A0A1Y2BB25"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="146" mass="16124" checksum="8A34358265CE474B" modified="2017-08-30" version="1">MSAALKLCPRRLPSPFIQNLVAGIFLPLEPGRLTARPDSGAGGSQATNTKASRRSSACAPYWTPLVSQNSGHCHPLAPIRLDKLHGQACFICRIDERHDRYRHLYHLVIDSTLLKWTTDTAYAFAIQAVGITIFAFLCFIQATDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBG3</accession>
    <name>A0A1Y2BBG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_525560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBG3"/>
    <dbReference type="InParanoid" id="A0A1Y2BBG3"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38569" checksum="B3FDDE58AFCD27DF" modified="2017-08-30" version="1">MPVPVYSATETQEVGSQNVGSLKLRGHHAIPTTSAYPELDTQGYTVVKGVISKEKAQEYVDRAYKWLEGFGKGFKGDDRSTWHIDNLPEFSKGGLYNRHGSGHEQFAWDIRAEPGVIETFAKIWGTDELLVSFDGVNVSLPFPEEEMGDRAKAWPHVDQSPLRRFKHCIQGIMNLHENGPDDGGLAVLTGSFPLYNEFFETHEDEAPPEGWSWRDSHNFTESQLQWFYDRGCKWTKIEAGPGDVILWDSRCIHYGAAAHGDRPRVATYICYKPAKDITPEMLELRKECVKNYDNTSHDPLMFRATGTRIYGKLTEDEQEKPRELPVLSERAQQLAGVKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBR6</accession>
    <name>A0A1Y2BBR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_523704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBR6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBR6"/>
    <dbReference type="InParanoid" id="A0A1Y2BBR6"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="9">
        <location>
            <begin position="77"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="586"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="791"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1078" mass="119152" checksum="4EB54B9AA4762162" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCS7</accession>
    <name>A0A1Y2BCS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_380820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCS7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCS7"/>
    <dbReference type="InParanoid" id="A0A1Y2BCS7"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="177"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="177"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="473" mass="52257" checksum="E24D05650EAC0A04" modified="2017-08-30" version="1">MGHPPRFHPYALSPEFIESIDNSSSSIRHPYEKIRMGAMISEVEDETVSPLSRPSFLASPLSLPRSPSHPLSVRATSQYVVPSARSLAPFNPSPTAVDPSARMYDYVSASNRSQMKVHRRSMIPDEHRNSNYDGAGNTSDDNEDFNHHDQRKWGQSDASHGLMEYDERYETVHKPDIPYSQMIRICISASPKKALTLNQHSVRHNLSINEQFLNLDRAVSDPAAGKGGYWIVVDQPPGKIHPPPASWLSQERPKVSKKASQPDRRGSITAKPYSVSHRSSLPTSNTSHRSSLPTSSISYRSSMSAQSTSHRASLSAQSTSYRSSPSSQDISHRSSLSSQSTSLQSPLSAQSLPFNLAPPQSHSQYPWTPLHHPPPATAVGTVPHVPTTSTHIDREILPNLEQPMSYQLPRILPDPRSTPSRDCGYSPANSAHVEAHEHLKKETLPPIRTLLEPVLGLGRPPGWNSLPATLGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDJ5</accession>
    <name>A0A1Y2BDJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_522052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDJ5"/>
    <dbReference type="FunCoup" id="A0A1Y2BDJ5">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDJ5"/>
    <dbReference type="InParanoid" id="A0A1Y2BDJ5"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY32844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="380" mass="41213" checksum="AEEACF9E578DEDA3" modified="2017-08-30" version="1">MDKDRVLSIQSHVVSGYVGNRAATFPLQTLGYDVDAINTVQFSNHTGYGHTNGHKTSPEELSAVFEGLVTNGLLNHPRVLTGYIPGASALRVVQSHIADMQAENPKLIYVLDPVMGDGGKLYVAEDVIPVYRSMLSLATIITPNHFEVELLSGSKITDMASLQDSLKQLHTTYGLPYIALSSIPLPASKVRALALPSPPSSYIDMLPESPPLWYEAVASAHSEDDVLVSFASTYLHGRLETWAFALPTIHGYFSGVGDFFSAMVLAHFDDAGSEPQAFVSAVSKALLAVQQILLRTHLYSLANANPSGMATPRPMHGSNLTSVIPSDAELDALIPADVKEPKRKARRMRIRELRVVQERALIAIESEGWPGAKVNLSESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE70</accession>
    <name>A0A1Y2BE70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_521378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE70"/>
    <dbReference type="FunCoup" id="A0A1Y2BE70">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE70"/>
    <dbReference type="InParanoid" id="A0A1Y2BE70"/>
    <dbReference type="OrthoDB" id="2563869at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="206" mass="22035" checksum="BF33A7C449F3DAEA" modified="2017-08-30" version="1">MLLDSTTSVTLPQIISNPPASFYSFPISSRTRVHTSIRGLAPSSSSSASGGPGPATQERQREKNACERALRRALVGQRPAGVALGREGEDLSDEEEALGAENQMVTQFGHRFLLPIGRRLTQMEMDAAASPTPSQPDDERRQEDRNVASVSPLVGGQPVLEGELEGEEGGEVVDLDASIEDLDASGDIEDLDEGDVETEGESMEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE96</accession>
    <name>A0A1Y2BE96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gti1/Pac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_504014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE96"/>
    <dbReference type="InParanoid" id="A0A1Y2BE96"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="522" mass="56014" checksum="D17B7209F25182D9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEQ6</accession>
    <name>A0A1Y2BEQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_522818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">High affinity uptake of sulfate into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEQ6"/>
    <dbReference type="FunCoup" id="A0A1Y2BEQ6">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BEQ6"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902434">
        <property type="term" value="P:sulfate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000046">
        <property type="entry name" value="Solute carrier family 26 (Sodium-independent sulfate anion transporter), member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="532"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="691"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="780" mass="85722" checksum="D1DDFC637B770383" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFC6</accession>
    <name>A0A1Y2BFC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_520372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFC6"/>
    <dbReference type="InParanoid" id="A0A1Y2BFC6"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="135" mass="15645" checksum="19ABF3375F93B2B5" modified="2017-08-30" version="1">MSQHSDRMHGHAGLVFFSHHLSAAVILFVHACFTSAVRPEIREELRTSARLFQQVPPESSFRWSKAVSQGGNIVQVMCDVRTHVLNGLMDRRSKIHRRRWKISRLCCWKFDGIQEDKTLPRSRSASNRYLPSLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFG6</accession>
    <name>A0A1Y2BFG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_520196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFG6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFG6"/>
    <dbReference type="InParanoid" id="A0A1Y2BFG6"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="113"/>
            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="328"/>
            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY33456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="398" mass="43820" checksum="6BA34B107B573E17" modified="2017-08-30" version="1">MSVTATEIIAGPSTSVAPEPNSPKYDDLELMPVPSVVSREAGERDPLLLRSKLISDEDIDGIRHRKKGKKIASFYEAQNEQIQSLLKPLSAHTAEGEQEASDNALKIKLAINLSLGANVCLAIVQLYAGISSGSLALLASCVDSVFDPFANLILWYAHRLSKTVEEKKWPARGSRFETSGNIVYGFIMGGVNLILIVESIRSLVTHSGDDTSDLHIPSIVAVGVAWGVKFALFCFCYAVKDQSSQVQVLWEDHRNDLFTNGFGILTSAGGSKLAWWLDPMGAMIIACGVIIVWTRTVYEQFTFLAGIAAPAEYQNLVTYKAMTFNSAIASVDTCRVYHSGPKYFVEVDIVLDPEMPLWKAHDIAQDLQDQIEALPDVDRCFVHVDHEVSHKPEHRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG48</accession>
    <name>A0A1Y2BG48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_557023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BG48"/>
    <dbReference type="InParanoid" id="A0A1Y2BG48"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="822"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
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            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
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            <end position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
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        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
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            <end position="408"/>
        </location>
    </feature>
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            <end position="462"/>
        </location>
    </feature>
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        <location>
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            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="541"/>
        </location>
    </feature>
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        <location>
            <begin position="545"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="955"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1160" mass="123216" checksum="16AFDB6693E8E220" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGP9</accession>
    <name>A0A1Y2BGP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGP9"/>
    <dbReference type="InParanoid" id="A0A1Y2BGP9"/>
    <dbReference type="OrthoDB" id="10616881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="281" mass="31713" checksum="8AD71F13D432CD43" modified="2017-08-30" version="1">MVSDLTSSLGTPLDRDFEVENRQLRERINALEEAVWQLQQKVTIREDSTTALLSGPNTLSPQVVSLALGLLCGVFQSSQPAPFQNGLTNLLIVTATVFFHLPPSPRDREVYSALSTSLALLLSTYDSTTVIDPYDYIDQLDFFAPPDIIWLFVHTADHALILTFRQVLRREIIMFPGTRRGLTCEVLYHALLPEINHGVGWFSKEEKVYVRVMAQLRGWKLGGDGLQRVDWEFIEDVIRPYGPEGKRNIVSGIEKSDSTGYTKRQKVEGWQQSIDGETLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGY1</accession>
    <name>A0A1Y2BGY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_519386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGY1"/>
    <dbReference type="FunCoup" id="A0A1Y2BGY1">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGY1"/>
    <dbReference type="InParanoid" id="A0A1Y2BGY1"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="48"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="208" mass="23270" checksum="51DF3CCA7ECCD167" modified="2017-08-30" version="1">MSIRNFFGAFSTRSAQNMAPKKSPPPPTVPTAIKTSEEAKLTDGVEHATFASGCFWGTEHLFQRYGNLPGFSVKSGYTGGHAKSPSYRQVCTGTTGHAEAVLLTYQKGAVGYGELVEFFYRTHDPTTVDRQGPDRGSQYRSAIFYHSPEQKEIAEKVTQEVQEKYLKGKPIVTQIVPAGDWWEAEPHHQEYLDNNPGGYECPTHLFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGY3</accession>
    <name>A0A1Y2BGY3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_518320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGY3"/>
    <dbReference type="FunCoup" id="A0A1Y2BGY3">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGY3"/>
    <dbReference type="InParanoid" id="A0A1Y2BGY3"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="2">
        <location>
            <begin position="164"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="281" mass="31479" checksum="94AC12FD1B6B7326" modified="2017-08-30" version="1">MGNLQKHSSSVKMQPTTSTMKEETERLAKKIVEAYKEIRPERRLLVAVAGPPGSGKSTLAYPLADKVNALVLQHPVSHPAVVVDDQERIAAAGQGAGEADEVCVCVGLDGWHYPREELDTFEDPVDAHWRRGAAFTFNLPSYLTFIQQLRLPLIPCPPIGIPYPTFDHALKDPRPSPTPITPRHRIIIIEGLYTLLSKDGWRQCAEMMDLRIFVDVDPEEARQRVIRRNFEAGIVDNLEKCAERVDAVDMKNADEVRRYMVTPTDVIMSVHEVALEHVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGZ0</accession>
    <name>A0A1Y2BGZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_518326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGZ0"/>
    <dbReference type="FunCoup" id="A0A1Y2BGZ0">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGZ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BGZ0"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="54"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="200"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="298" mass="33397" checksum="438EA3377F98FB25" modified="2017-08-30" version="1">MSRPEEISPPEIFYGDTEASKYTSNSRIQTIQAQMTERALELLALPPDESAFLLDIGCGSGLSGEILDEEGHVWVGVDIAPSMLEVALEREVEGDLFLHDIGQGFGFRPGTFDGAISISVLQWLLNADSTSHSPSARLTRFFTTLHASLRNPSRAVFQFYPSSDDQVTMITAAAQRAGFGGGIVVDYPNSKKARKMYLCLMVGQQQPDQSRIPQGLQHEGQVDNKRDKARKRDEIQNERRRRRDDKAGQKRGKGGKVKGGQVNPKEWILKKKDLYRTRGKEGVPRDSKYTARKRRVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGZ6</accession>
    <name>A0A1Y2BGZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_491534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BGZ6"/>
    <dbReference type="OrthoDB" id="5150166at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="15"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="382"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="72695" checksum="0AEA1A378B81F65C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH19</accession>
    <name>A0A1Y2BH19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_463099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH19"/>
    <dbReference type="FunCoup" id="A0A1Y2BH19">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BH19"/>
    <dbReference type="InParanoid" id="A0A1Y2BH19"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="114"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="877" mass="94121" checksum="76AAF3FCC17C6B05" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHK0</accession>
    <name>A0A1Y2BHK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Etoposide-induced protein 2.4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_575803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHK0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHK0"/>
    <dbReference type="InParanoid" id="A0A1Y2BHK0"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38603" checksum="042E1768D4B30AB1" modified="2017-08-30" version="1">MPSELLHLPPAYTLVGIYRLVTDPFIRQPVLDKIKHASIRGIVVGVVYAAGSWKILDWFVRTFLVGGGGWFGRKQVEAAISKSDRGHVWVGLGQFGVSLDLVLYTHLLILLPQLSSILRFFIYKNLRLARSRAFALTVSSRGKPKEFWNQGYIEEWAQPPRPARGEILGVGSRKSREARWISWILWWPTQLFLRHYLLLPLSPSLPLLAPLLTSTLRAITTAEYLHQPYFETKGMNQEEVWRWVEERRWAYMAFGFAASLLESIPIVGLFLSISNRIGAAMWAHDLEKRQHLFSHGILSPLPPDQTGFYGMGAVTDLGVDIQQAEDQIEQKWSKKRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHM7</accession>
    <name>A0A1Y2BHM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_517453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHM7"/>
    <dbReference type="FunCoup" id="A0A1Y2BHM7">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHM7"/>
    <dbReference type="InParanoid" id="A0A1Y2BHM7"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="202" mass="22822" checksum="126EA24B5AC46048" modified="2017-08-30" version="1">MSWRHYLPPVQPVKLVKWLAAAHFTTVAIAHVQQCQGPSMAPTLDPSQSAWLFVSPLPYWSWTSWTPRWKGPKRGDLVFATKPTLPDVLVCKRVVGLEGDLIEVEPRRDDPASRWMDKVIIETDGTDVLGGTTPRRRGQEQWIKVPKGHVWLVGDNLKNSTDSRDYGPVPLALVKGQVLARVWPNPTWFRDPFKHISGPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIB9</accession>
    <name>A0A1Y2BIB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_517530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIB9"/>
    <dbReference type="FunCoup" id="A0A1Y2BIB9">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIB9"/>
    <dbReference type="InParanoid" id="A0A1Y2BIB9"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000670">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="558" mass="59598" checksum="A8A0471103B3A485" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIF2</accession>
    <name>A0A1Y2BIF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_513385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIF2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIF2"/>
    <dbReference type="InParanoid" id="A0A1Y2BIF2"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="284" mass="31489" checksum="025457B437260F0E" modified="2017-08-30" version="1">MVKLSLESTVKLSSGNTIPQLGYGVYQARGRECSDGVVEALKSGYRHVDSAQAYRNEDLVGGALSTAKIPRSQVFLTTKYMPTHQEHSVASVYSYLQKSLHKIDPESKEPYIDLMLIHAPWGGDEGRANNWAALAKAQKEGWIKDIGVSNFGVKHLEALPEPVPVINQIELHPFCQQREIVAYCEKHNIKIQAYCPLVRGDAKRFSNKVLVGISEKHGKEPSQVLLRWSLQKGYIPLPKSVTPSRIKSNADLYDFELDQGDMKALDGLDEGAKGACSWNPVDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIJ2</accession>
    <name>A0A1Y2BIJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_513559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIJ2"/>
    <dbReference type="FunCoup" id="A0A1Y2BIJ2">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIJ2"/>
    <dbReference type="InParanoid" id="A0A1Y2BIJ2"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="121" mass="13183" checksum="9AFE08C7318314BA" modified="2017-08-30" version="1">MTLIETSYPPPDSAIASTETEPTFLIFFSTREGGQLWCPHCRDVEGIIDSTFKGASKPKGVITHVGSFAEWKTPSTPHPARAKYGVEKLPTIVKLQNGKIIGRAPKADIVDAEKLDAFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIW1</accession>
    <name>A0A1Y2BIW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar protein,Nop52-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_514169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIW1"/>
    <dbReference type="FunCoup" id="A0A1Y2BIW1">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIW1"/>
    <dbReference type="InParanoid" id="A0A1Y2BIW1"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="362" mass="39964" checksum="95C06C64947C2083" modified="2017-08-30" version="1">MSTTTLTRKSKGKSRATQNDKVEAALPLGKQLAHTDKQVRDRAIASLVAFVSAGAQDGGPSTSSAGYTPLAEGEMDKLWKGLFYCFWMSDKPLVQQSLASDLAELVLKIQPRPARSKGINLSEEKIELDDERFDAALGFLAGFWRSMVREWHGIDRLRVDKFYMLIRRYVNATFRLLARGGWKEEQVGRVNDVLAGKGGPITVDVSVPKALAGHLSDIYLEELDKVLGLPEVDAQRACPTLSVLGPHIALLALTPTQSIYNRTMSTVFTPLLSALTLASPSTKDIVDRPSKRSKDDPIFPHIVMRSRLAGSDQLASPDKLRKGLVKALFEAAADQSAVETNRRKIYQIVRELDDDEDEDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJW2</accession>
    <name>A0A1Y2BJW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_516476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJW2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJW2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF101">
        <property type="entry name" value="HIGH-AFFINITY NICOTINIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="486" mass="54575" checksum="8D0E22CA84360CE2" modified="2017-08-30" version="1">MSTTPSHTTIEEKAIYADVTPVNEILELSDEDKIIEKRAKRKVDFNLIPVFGALYMMSFLDRSNIGNANLTTFNKDLGLVGNQFGAAVSVVYATYVVFEPVWAVLMKIITPKILLTGCTICWSALCLGTAFIKNYPQLMAIRVLLGLFESGMIPVTTLYLTTTYMRHEYVSRQTVVFVFSAASSAFGGLLAYGLSHVDRAGLVGWQWIFLVEGLISFCLVPIAWFWVPNNVTEAWWLNDEDKRVWKIRQDINRRIYDDKEVFKWDWIWNVLKDYRLYVHAVSHFGIDCTLYSLTTFMPTIISGLGFSTRVESQLLTVPVYVIGALGYIVSGLLSSKYRIRGVFIAVALCFCLLGYILLAAVKAPGGRYAGVFIAAIGLYTTTSLHVLWCGDNWSGHYSRAFAMGFIQLVGNSSGACIGFIFTAQTAPYYHKGLYFDIGMTCMSLCCTLYMINYYRLANKKKRAAVEAGASDDRDLGDKNPHYAYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJX5</accession>
    <name>A0A1Y2BJX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_563628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJX5"/>
    <dbReference type="FunCoup" id="A0A1Y2BJX5">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJX5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJX5"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="113"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="550" mass="60020" checksum="40CE098EFFE39DA8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKQ1</accession>
    <name>A0A1Y2BKQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_508885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKQ1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKQ1"/>
    <dbReference type="InParanoid" id="A0A1Y2BKQ1"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF3">
        <property type="entry name" value="(3R)-3-[(CARBOXYMETHYL)AMINO]FATTY ACID OXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="40"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="338" mass="38109" checksum="BD1E914D95E518A1" modified="2017-08-30" version="1">MSHTLTETSTTATTSIPPTLQLRGEVGLLRVRPVVQYEGGGTFGAEVEGVDWSKPIPDDVVDQLIALEDKYAVLIFRQTGLDNDGHIAFSQQLGADLEVNPFYYGRENDRVGEPYLWDVGNIELDGSLVKPNSRRWHHSLGNTLWHTDSSYHQRRSKYSLLLSHGDPVRGGSWTHFADTRQAYTDLPEELKLQLEDLIVEHDLWHSRKLGSPVVYGNPLPHEKAAKPPAYHRLVQISPGGQKALYLAAHAKTVSGMSLEDSQKLLWKLIDHCTQPKYVFSMEWLNAGDMVWWDNRQSMHRANPYTEDMTARDVRRSTVIDDGPLAWGVPDAKSLFTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL35</accession>
    <name>A0A1Y2BL35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_510076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL35"/>
    <dbReference type="STRING" id="71784.A0A1Y2BL35"/>
    <dbReference type="InParanoid" id="A0A1Y2BL35"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="672"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="949"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
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        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1144" mass="120257" checksum="02C88B1D26186B50" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL36</accession>
    <name>A0A1Y2BL36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="11">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_509875</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="11"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL36"/>
    <dbReference type="FunCoup" id="A0A1Y2BL36">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL36"/>
    <dbReference type="InParanoid" id="A0A1Y2BL36"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000004">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="196"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="515"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1069"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY35466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1100" mass="123132" checksum="B7AF3547FA7EDA54" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL66</accession>
    <name>A0A1Y2BL66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_502671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL66"/>
    <dbReference type="FunCoup" id="A0A1Y2BL66">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL66"/>
    <dbReference type="InParanoid" id="A0A1Y2BL66"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000541">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="159"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY35357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="802" mass="86821" checksum="F8DFDE96FEF7B1E3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLN8</accession>
    <name>A0A1Y2BLN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BCR39DRAFT_511326</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLN8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLN8"/>
    <dbReference type="InParanoid" id="A0A1Y2BLN8"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012598545" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="178"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ORY35651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="475" mass="50248" checksum="7FA58AE3A2F805DC" modified="2017-08-30" version="1">MLAQAFLSALLLVGSGAHAHKGCGGQEVMRRNPGGRNIDSYAEYASELKRGREGRLDRRQATPTDEASGAESTDPSFECTGYSYAPWAALKANYPTIWETATILSTDTDAQTLFATINSSVAAKFPNIGPKGTNSGDFTGVTYDYGTDPDCWWTDHECTTPAADTGLAADITTVPEALTWGYGFDDGPNCSHNAFYDFLQDNGQKATMFYIGSNVADWPLQALRGYADGHQIAVHTWSHRYMTSFTNEEVFAELYYTRKLIKDILGVTPKYWRPPYGDVDNRVRFIAAALNLTNVVWTDDSEDWKEGVPADNVTAADVTANYQAVIDKAGNGTYTSSGPVVLTHELTNFTMSEAISQYAAIKAAFKYMVPIATAYNDTNPYEETNVTYPDFLTYTNQSSSSSSSSSSSSSASAGSAGLTASSGGSSAAASGSAAATTTSGASASTTSKAASSAGRIEAGVLGVAVGLGGAVAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLU1</accession>
    <name>A0A1Y2BLU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BCR39DRAFT_510519</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLU1"/>
    <dbReference type="InParanoid" id="A0A1Y2BLU1"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="1733"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORY35537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1783" mass="193531" checksum="F0349AB4E88846F0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM80</accession>
    <name>A0A1Y2BM80_9TREE</name>
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        <recommendedName>
            <fullName evidence="9">SWI/SNF chromatin-remodeling complex subunit snf5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_37565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORY35868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM80"/>
    <dbReference type="InParanoid" id="A0A1Y2BM80"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
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        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="1234"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="1456"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <end position="67"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <end position="251"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1534" mass="168377" checksum="3D33E833E49D155E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM83</accession>
    <name>A0A1Y2BM83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_512657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948">
        <property type="entry name" value="ZGC:113208"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
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    </feature>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM97</accession>
    <name>A0A1Y2BM97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferase family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BCR39DRAFT_461435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
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        <lineage>
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            <taxon>Tremellomycetes</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
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                <person name="Clum A."/>
                <person name="Lindquist E."/>
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                <person name="Ramamoorthy G.K."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58994" checksum="604FCE21C84F9EE2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMB3</accession>
    <name>A0A1Y2BMB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mannosyltransferase putative-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_512910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMB3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMB3"/>
    <dbReference type="InParanoid" id="A0A1Y2BMB3"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="512" mass="58564" checksum="9E6851690546D770" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMC9</accession>
    <name>A0A1Y2BMC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_460805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMC9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMC9"/>
    <dbReference type="InParanoid" id="A0A1Y2BMC9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="546" mass="60821" checksum="AB7DDBED30E135A7" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BP45</accession>
    <name>A0A1Y2BP45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_513114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BP45"/>
    <dbReference type="FunCoup" id="A0A1Y2BP45">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BP45"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="504" mass="55600" checksum="3B3795C3C1C4A523" modified="2017-08-30" version="1">MGSFAHKLRVAVWGEKPETKQERILVMKIDTVILTYSCVSYFFNYLDRAGLANAYVSGMKEDVHLVGTNYNVITTCLTVGYIIGQVPHALAIQKISPRIWFPAMVAVWGGLTMCCAAAKTFQHLCVIRFFQGIVEASTYSGTQYIIGSWYKPSEIGKRTGLFAASGMAGTMFSGIMMTAIHSTMDGKHGIAGWRWLFIILGIITIPVAAFGFVFFPDVPDRCKAFWLTEDEKQFAIARLPPRPPNAQRNRLGWSLLQRVLLRYEFWVLTMLWVIGGALEAFSTQTCMLLWMKATGRYTVSNNNTYPLGITAVGIFLTLATAVLIDASGKHMPWGFVACVLQIVACIILIIRTIPDGAVFAGYFIAGSAYMIQPVCFTWANKILIKTGDDAARAITLYSMNGASSVLFSFWGIILYPATDASKRFRKGTIAMFVISAVLALWIGLTWALDRSITRKAQQAAGEAEVEEHKEWVDPEETKEMDTHPSLMGSTNIPIVPAPPTGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADA8</accession>
    <name>A0A1Y2ADA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pleckstrin homology domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_474985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000132">
        <property type="protein sequence ID" value="ORY20538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADA8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADA8"/>
    <dbReference type="InParanoid" id="A0A1Y2ADA8"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="766"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="917"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY20538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1027" mass="111229" checksum="0D86E83FA5461B41" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADW2</accession>
    <name>A0A1Y2ADW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_554825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000126">
        <property type="protein sequence ID" value="ORY20749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADW2"/>
    <dbReference type="InParanoid" id="A0A1Y2ADW2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="98" mass="11599" checksum="ABB52ACC465E2FA4" modified="2017-08-30" version="1">MSRIGQLLHPNYLLYSLQDRQHGDWRVGESMQSVINTRRELWFHIYIHIIGMLLVICSTYSIGNISVHPYRKERQPSTLSPGFRRYRIVHSDSISRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEU5</accession>
    <name>A0A1Y2AEU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_554437</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000121">
        <property type="protein sequence ID" value="ORY20954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEU5"/>
    <dbReference type="FunCoup" id="A0A1Y2AEU5">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AEU5"/>
    <dbReference type="InParanoid" id="A0A1Y2AEU5"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="19">
        <location>
            <begin position="250"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="18">
        <location>
            <begin position="848"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY20954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="961" mass="105896" checksum="7298E18E14728E31" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF69</accession>
    <name>A0A1Y2AF69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CrcB-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_554574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000122">
        <property type="protein sequence ID" value="ORY20917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF69"/>
    <dbReference type="FunCoup" id="A0A1Y2AF69">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AF69"/>
    <dbReference type="InParanoid" id="A0A1Y2AF69"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY20917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="423" mass="45576" checksum="41418B50FD0EB13E" modified="2017-08-30" version="1">MSTQAVAVDRAGMGPSRNGSRSSAFNQRSPSLFRSRTQDGAIHPSISRNTDMTRSSLDPERPDPPRPPSPPPREENAPPPADEVTHSRLAAHYSGLVLASMIGTLIRLGLDALATYDGMVIYSLAWSQGVGCGIMGLALARKNDIVSIYPPLYTFLTTGIAGSVTTFSSWMLDGYLSFSNFDKYNRKGLHDTVDGLAYSFSTFAIALACISLGAHMASIFPPLPRPSHQDSDISLSKEQQDPVDPPPKSPTRRTLTGNTPFLDISIICTAALAYLAALLLYFLAPASWRHRATFAILLGPPGTILRFALARLNTHPAFLDRFPLGTFLANIIATLVISGVYAAQRRPEVIGHSTTCNALYAIQQGFCGCLSTVSTFAVEARAIKGWRWKWFYIGGSVVLGHVLVLAIVGGIGWSEGYADVCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFY7</accession>
    <name>A0A1Y2AFY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_508350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFY7"/>
    <dbReference type="InParanoid" id="A0A1Y2AFY7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="239" mass="26011" checksum="561C85CF0317490F" modified="2017-08-30" version="1">MDLTGGCARRFGSFPRITLPVHCTPAIPNSDPNSLGLATPAGSSGDLVWRMLELPSKYGVIGRKRDESLSREMGSRPSYPHCSSGHNVGERHVSGAVFWGGIIGWVQHKAIWISHSLSTVKRPKVTSHYQSVTIQAAADRVGTLRLSINFNTSHFLKSMATKTSARKPVLPLMSVSEGDKDSARLWARGQSIPPYRKRKKRVPVNAALSWRCRGGRGLPDPGKQPSRGEKGPRVALEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH11</accession>
    <name>A0A1Y2AH11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_591484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000104">
        <property type="protein sequence ID" value="ORY21796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH11"/>
    <dbReference type="STRING" id="71784.A0A1Y2AH11"/>
    <dbReference type="InParanoid" id="A0A1Y2AH11"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="6"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="721"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY21796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1038" mass="116268" checksum="1C2CB7EE7128C01F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHF3</accession>
    <name>A0A1Y2AHF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_591420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000099">
        <property type="protein sequence ID" value="ORY22028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHF3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHF3"/>
    <dbReference type="InParanoid" id="A0A1Y2AHF3"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="217"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="253"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY22028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="322" mass="35638" checksum="B1A6D1E26491A6AC" modified="2017-08-30" version="1">MEPSTSTPIYTVLRIKRKATEAPLSSLVIQDDPSTRGIKKRRDVSGRARGVFRLAETVPDKWEGGPSQEAALKERIETLLARKSPSLAVGMGVSGETKSVKRQTESLTVPRVSQIPSSKSGSSMPGLKYRVVPPTSPRSRSMIPPKVLSIAEIEQARKALTFVDAEAVSGPTPAETAQGLKEDKEMEAFLPMLQEYLQLEQDTGTRTRSRSGPVRQEEYVYDLYYRDLRPSLSSTPLGLGLGDGVGIGALLGYSDISPTSSPESSEPEDEADEDSNDEDYYRNDYPEDEDADEDMQDFRDPYDESDQESAGSDRDRGQWEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHP9</accession>
    <name>A0A1Y2AHP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_552381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000099">
        <property type="protein sequence ID" value="ORY22026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHP9"/>
    <dbReference type="FunCoup" id="A0A1Y2AHP9">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AHP9"/>
    <dbReference type="InParanoid" id="A0A1Y2AHP9"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="415"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY22026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="491" mass="55491" checksum="44AD810EAD6FB078" modified="2017-08-30" version="1">MVQPSFAHPRRTQASKSTTPTAALDVFLDNQHQSYFEDLYKSEAVCLCILRLLPPVCRQIILHNLWSYSAVKVIDIKAFCQIDIAAPLESVLDIMRPVLDRKILGQMQSKKGKMEFPWNDTFKKGLRNALTGLGTSNSFGVPAEIEEESSLDVDDLTRYGEDTWESILRYMVSSGLGKGLTTSRPKHSVLLLLHFSGLMVDLTDPTGRKVSLERLTITSKGFQFLLEDRQTQLWQVLMFYLTSKDENRQRSADVLSLFFSLGCMELGQGYSASQSFPTSQSVLEDLESYGFIYRPVSADGVRSDTFYPTHLATSLCSGDIGSSQSAEDKRFLILETNYKVYAYTSNELEIAILNLFVDIRIRYQNLVVGKLDRGPVKAAMEKGISASQIISYLSSHAHPQMHASPPPLLHPTIVDQLHLWDKERNRLKTDEAIMYEFFSKELFEASEAEADKYGGMILSLPEQKRLFVDPALKEAMRDFVVARQTELRSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHU0</accession>
    <name>A0A1Y2AHU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonyl/alanyl tRNA synthetase SAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_552207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000098">
        <property type="protein sequence ID" value="ORY22131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHU0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHU0"/>
    <dbReference type="InParanoid" id="A0A1Y2AHU0"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY22131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57596" checksum="B8866CCB8953A472" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIB0</accession>
    <name>A0A1Y2AIB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_508147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000095">
        <property type="protein sequence ID" value="ORY22321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIB0"/>
    <dbReference type="InParanoid" id="A0A1Y2AIB0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010995103" evidence="2">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="135" mass="15504" checksum="035AB2192C763F8D" modified="2017-08-30" version="1">MPATMVRASLLSLFSHLIPFLVLNHLGLCLSMGHRVQLMPSFVGLWPFMTSADLIARGVMHLRLAQSQEPVRAQVGKDQEGRHGRGEEEEEGEEEEEEERWIKEEEEMLKFLNADRPIDDDVPVGQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIL8</accession>
    <name>A0A1Y2AIL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative mitochondrion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_552387</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000099">
        <property type="protein sequence ID" value="ORY22027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIL8"/>
    <dbReference type="FunCoup" id="A0A1Y2AIL8">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AIL8"/>
    <dbReference type="InParanoid" id="A0A1Y2AIL8"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="16">
        <location>
            <begin position="107"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY22027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="486" mass="54679" checksum="EF93699F7609E61D" modified="2017-08-30" version="1">MPLGLSTAHLSTKQSLVLAALASCVATTSLILTFQALRRDYRTERLKKRVGQDVEEWEKSRAGSGWASPEEVAERHAEGETTPGGGRRVKEWAKGEFDEGLIREQLTRNYNFLGEESMKKVRDGYVVVVGCGGVGSWCALMLLRSGVGRILLIDFDLTTLSSLNRHACATLEDVGTPKVVAMQTYLRKVAPWAQIDIQVGLYRKGESEQWLEGADWVVDAIDNIETKVELLTHCHKNGIKVFSSMGSGAKRDPTRIQIADISNTYEDPLARSVRRRLRMNGISSGVPVVYSTEVPGEIKLLPLPEEEYQRGSVKELQAFDDFRVRIMPVLGPLPAIFGLQIATYILLSLADRPLTDAAEIKNRRKLYQSLERTLAEREQKIHKLESQAKLPISAEDLGWVFEDLYHGRATFPPYPVLPRPCVVRWDREKELLEDNVVIMAANDADKHTKECLEGGKSLEEVWGDEVVKIVKRKSEEARKIMLWRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIV0</accession>
    <name>A0A1Y2AIV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase family M48-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_551392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIV0"/>
    <dbReference type="FunCoup" id="A0A1Y2AIV0">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AIV0"/>
    <dbReference type="InParanoid" id="A0A1Y2AIV0"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="241" mass="26191" checksum="AE74801E5908EE58" modified="2017-08-30" version="1">MGHVEARVPAWSGSGGADEGMDVGEIFFGGGKAANHDEGKETEWEVYVIDDRETKNAFVLPGGKIFVFTGILPVSQNDDGLATVLGHEVAHQVARHPAERMSYMKVLFVAGLLLESLGLDVGFSRALLTLLLQLPNSRTSESEADYIGLRLMSRACYNPEESTRMWQRMSESEKGRSVAGSVDFLSTHPANAKRIKQLQKWMPEAQQIRAASPCGATSQQFGGFLDTLSAANQGMGKTLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJK0</accession>
    <name>A0A1Y2AJK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_372672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000089">
        <property type="protein sequence ID" value="ORY22696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJK0"/>
    <dbReference type="InParanoid" id="A0A1Y2AJK0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="65" mass="7464" checksum="DC2C2753143143EC" modified="2017-08-30" version="1">MTRGGQRERDREKAAAAQQKVKTKLTGDPQKRKEQDAKALADKIAQKKQKQLVLLVPKRRNLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJT8</accession>
    <name>A0A1Y2AJT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_600992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJT8"/>
    <dbReference type="InParanoid" id="A0A1Y2AJT8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="229" mass="25067" checksum="095B9864FFFB2049" modified="2017-08-30" version="1">MNDSTTASPTQIIASTQSQVPADNACLTVIPYTPPAFGFATNDTSISNPRTSHSMVSSVSPTVTDSNVFIQPEETHRSSSALDGWGEIVSVFGTRLTAMEVRPSGFVFDRNWTQSIESLRTNIMAQQTALPSDNTDGHWQAENLLINLEVLHEILSLSIMSIRNIANSSWITAASQTEGPEISRSNPSLQSVRETESVWQLKLGKSFQPLRMSTRRLDSPVTGWIIGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJU9</accession>
    <name>A0A1Y2AJU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aft1 HRA domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_567050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJU9"/>
    <dbReference type="FunCoup" id="A0A1Y2AJU9">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJU9"/>
    <dbReference type="InParanoid" id="A0A1Y2AJU9"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="464"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY22580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="543" mass="57427" checksum="E93E67EFDC833672" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK73</accession>
    <name>A0A1Y2AK73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_366752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
        <property type="protein sequence ID" value="ORY22968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK73"/>
    <dbReference type="InParanoid" id="A0A1Y2AK73"/>
    <dbReference type="OrthoDB" id="2575638at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21805" checksum="69D12D8BCC97FA27" modified="2017-08-30" version="1">MAIHSSVNAHLEIELSALIAIRRHSMHQHRSQVFLQRLRAVERAGKILQRSLATGSPRLDLLHKMSTVILIASKASLRIIDLNYFLPLHTLLVAIYARLFAIVTSVLAEAEASTIAPESATHAITVTPKAEARIENKPSTFSGSSGNADRSLQDSSNVQNRLSPPEPAKLPNDSSVKPLQPQGRLKKRRKNEIDDIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK91</accession>
    <name>A0A1Y2AK91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
        <property type="protein sequence ID" value="ORY22988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK91"/>
    <dbReference type="FunCoup" id="A0A1Y2AK91">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AK91"/>
    <dbReference type="InParanoid" id="A0A1Y2AK91"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="203"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="375" mass="41341" checksum="44F3E8E798749596" modified="2017-08-30" version="1">MSTRDGLGPPSEEFLRSKGRLATLGMFVIDHFSVTDSEGIPIPSDEEAIGGGGIFAMTAARLFLPPSSCSLLVDKGADFPPQFERQLREFGYDMVWFRPRSGPTTRAVNIYSGTRIGEGHQSFQYLSPQLHLFLRNLILPPSPFATQHLPEWIHVVCNCERARAIVDEMIYIRNGHLEEGLGKGWKGQMIWEPLGKACRAEELEEILHLAPSFAVFSPNLLELQTILSIKPTEPATLKDAEFAAHAFRDKLAGSGRDVPAIVVRAGELGSYTLSTTWTGWVPAFWGEDGQDKVVDVTGGGNGYLGGFMAGLLISDGNMRTASIYGSTAASFAIEQRGLPRLSNTPHGERWNDDDPWQRLYTMARRVDEAERNATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKL0</accession>
    <name>A0A1Y2AKL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_370825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKL0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKL0"/>
    <dbReference type="InParanoid" id="A0A1Y2AKL0"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="112" mass="12785" checksum="2FCAA574F1DBF04A" modified="2017-08-30" version="1">MLIFTCNYPLVMAIRSTNVYEERALGLHGEHAPHQHNQQKQNGEIFSKYLRHHLLPQIFFDLWPVAIGTLFICVLERGKLMNTNNVGWLGVWQILFEVTSGYGTVGLSFGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKN0</accession>
    <name>A0A1Y2AKN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolar protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_550178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKN0"/>
    <dbReference type="FunCoup" id="A0A1Y2AKN0">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKN0"/>
    <dbReference type="InParanoid" id="A0A1Y2AKN0"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="852"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="852"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY23054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="909" mass="101343" checksum="61E262CEDFBBE707" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKU8</accession>
    <name>A0A1Y2AKU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_595637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKU8"/>
    <dbReference type="InParanoid" id="A0A1Y2AKU8"/>
    <dbReference type="OrthoDB" id="3426336at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20302">
        <property type="entry name" value="cupin_DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="1">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="176" mass="20149" checksum="54B01D58E7C3A2CE" modified="2017-08-30" version="1">MSRPTDISAVPYQGPPLFAVPDDLVHLDVLNIDKTDERLWVPQGKDVWFRPLLFSTSQGYFVNLLRVRKCGILSRHRHAGPVHATVLRGRWHYLEHDWWAEEGSYAFEPPGDIHTLEVPDGVEEMITLFHVTGAYIYCDPMGKPEAIEDVFSKIDLARAHFEKVGLGADFVKHFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKY4</accession>
    <name>A0A1Y2AKY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_550489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000086">
        <property type="protein sequence ID" value="ORY22897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKY4"/>
    <dbReference type="InParanoid" id="A0A1Y2AKY4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013390775" evidence="1">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="105" mass="11604" checksum="0F6AE001D6D2F6AD" modified="2017-08-30" version="1">MFHFLTLDLSLVAIELPALRPSMALSSGLVDLVLVSLQFSTHCYSIMTMLHEMPAKDPVFAVSTVRINVNAHQSRVASFALNIRLQTITALLFRSIQVEVSHLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM71</accession>
    <name>A0A1Y2AM71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_343940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM71"/>
    <dbReference type="InParanoid" id="A0A1Y2AM71"/>
    <dbReference type="OrthoDB" id="10659587at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="506" mass="56291" checksum="D474C12DDA07A65E" modified="2017-08-30" version="1">MSTKQRRTTPCTQCRLEHLSCKWDPASTGVKCKRCRIREIDCSGPWRKTVPACASCVRSSVRCERREGQLLCLRCQSRGNVCPLPPRSSNASKCARIHVARDVRSCRTSVVKSPILAGLLSGAMRNAIRSKGALHLQRLQLPYAHSGKRLEMLDDLSDIVATIAGLKFCNSVSLSGKSQVHSIEDMTPTFWLTHRNSTPSVQSHGLQELASELWSLFVQIPSLDLSHYDSVVQLVVCLRTALKFRIWRQDKERCETVRTVLAYVTLLALVTLKSSAPSNEHHTLLIVSAVQLADREARLSATMGVPSRLAQPILCLLPSIAELPPIPDVFKVSALLSLNDADVWRLLNPLTETLFRLSCSLGSQQGNPFTIWRYINRVYSYLDRLNDAVHHTLGDRAGGVARSIFCVQLCAIEADILVVRMCEEKEIATSRSFAASNRAVRGLMPLIVSSHNLYRAVHAHTERQQQGDIRLSELYHVLDCFVIILESIGEDLVVCAGRLDLGARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANC1</accession>
    <name>A0A1Y2ANC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Evolved D-pantonohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_472731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANC1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANC1"/>
    <dbReference type="InParanoid" id="A0A1Y2ANC1"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="394" mass="43487" checksum="5F1EB88C57B0DC32" modified="2017-08-30" version="1">MREITPKSFDGLILPDTSQRIDLKEYNVLEFVPPPHKHHGKMIWVPPGLTNESMKARPFHVYDPEFLPIIGLYPTMTLIAETDVDPLFHEATAWYPPTDEFFFAQNAGAKAAGTGMAKSAIVQKIDLQQAERIRLEDKGEKIQIDVVSDGSEGIVNPNGATNWNGQIVFCAEGQGDEITTGLVLMNPLEPHNTTVLLNNYHGRQFNSLNDVVTNPRNHELYFTDTVYGHLQDFRPKPGLRSQVYRFDSKSGQVRAVADGFDKPNGIAFSPSGRHAYIADTGISGGFYGNDYTAPATIYRFDVAQDGTWSNRQLFAYISVGSPDGIHCDDKGNVYAGIGDGVAVWNPSGKLIGKIFVGGVVANFQFAGRGRMIILAETHLWYVTLRAKGAEIHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANM0</accession>
    <name>A0A1Y2ANM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_335530</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANM0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANM0"/>
    <dbReference type="InParanoid" id="A0A1Y2ANM0"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013345059" description="ABC transporter domain-containing protein" evidence="15">
        <location>
            <begin position="21"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="901"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="945"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1011"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1100"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="450"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY24112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1124" mass="122471" checksum="4F35C2CB6824251A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANT8</accession>
    <name>A0A1Y2ANT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_595395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANT8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANT8"/>
    <dbReference type="InParanoid" id="A0A1Y2ANT8"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011965710" evidence="1">
        <location>
            <begin position="18"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="539" mass="61396" checksum="AAE3FA6364A4B414" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP60</accession>
    <name>A0A1Y2AP60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BCR39DRAFT_472450</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP60"/>
    <dbReference type="FunCoup" id="A0A1Y2AP60">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AP60"/>
    <dbReference type="InParanoid" id="A0A1Y2AP60"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="55"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORY24302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="595" mass="65773" checksum="3E6459D652CCA2FB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APF1</accession>
    <name>A0A1Y2APF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_590559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APF1"/>
    <dbReference type="STRING" id="71784.A0A1Y2APF1"/>
    <dbReference type="InParanoid" id="A0A1Y2APF1"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="284" mass="31277" checksum="EF92082CF9F7CF07" modified="2017-08-30" version="1">MVKTILVTGATGQQGGATVRALVESNKTVKEPFSILALSRNPTSDASIALGKLENVEVVKGDLNEPDSIDQLFEAHGPIYGVFSVQSTFVPGEETAQGNALADLAAKHKVQHFVYTSTDYSGLAPHPVPHYEAKRLIEEHIHGLDLEWTIIRPGGFMSTFHWPPLLAAITTMLRKDRRFPVIDVGDIGRAVATIFSDKESFVGKTIHLDGDEPTPSDVVEIFKELTGRDISAKEPPDLGFPPMEKALKTINEHAYIGTPEETKKYFPWVKDLRTFVSENFPKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APQ6</accession>
    <name>A0A1Y2APQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APQ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2APQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2APQ6"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24129" checksum="1015E307D3E8315D" modified="2017-08-30" version="1">MPSSKGKPTDPELREEIKEKVKGEGNKDGSGKGQWSAWKASKLAKEYEKEGGEYENEAGSKNEPKKGAPEHKSEAKKTSETTAEKPKSSGKPKSKKDEEKKSDKPVSKKDEDKSKASAKPRSSGKKDEEKVDKPKSKKEEEKENTTKPRSKKEDKSDKPKSKNENDKPKSSGKPKSSGKKEEPADKPKSKSKDKTEAGTKRKAEDEGKPASKKKETAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ49</accession>
    <name>A0A1Y2AQ49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC transporter transmembrane region 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_546061</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ49"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQ49"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ49"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000800">
        <property type="entry name" value="ATP-binding cassette sub-family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="485"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY24671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="739" mass="83077" checksum="17D88018E54D763B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQA0</accession>
    <name>A0A1Y2AQA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_546031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQA0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQA0"/>
    <dbReference type="InParanoid" id="A0A1Y2AQA0"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="151"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="358"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="394" mass="43939" checksum="C547F43134B771CC" modified="2017-08-30" version="1">MPLLRSSSALVIRCFKSVENCADWITGAAGPVFVTLAWLLIVAGGIGFFDVIARQLPIFLSILLSPIFFLVPLNLYGQYYLVTHVPPGFPSSRAMGLSPHRALSTDTESRWLVPKPSSIFSAERWGLGKRGMPLSGMDGYADIRAQGKRVRRCRKCDGPKPERTHHCSVCKRCVLMMDHHCPWINACVGLHNQRHFVLFMAWLSIACWTVGMLGFKRFWESFDYHSPWPCYTPRIVFTLVYVLALAIGIAVPVLMSWHLYMVSNGETSIESHDNDYLGRKAKAEGLIYLNPYDLGRRRNLETFFNIGPNGYPMTTLLFPLLIPPASNGWSFPRRPLPSLSQHRPTVDLHSPELSAGLMSSSAEHGHASHNAGGYVMGDEDGLTDDEEGGGGWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQU8</accession>
    <name>A0A1Y2AQU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_545323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQU8"/>
    <dbReference type="InParanoid" id="A0A1Y2AQU8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="337" mass="38355" checksum="E70511DA5988F3B6" modified="2017-08-30" version="1">MGKESQDDPWSSFDAFIERMRDTTGDIDIKPWDFPLPPADENELKTPLDREPATPRSPNKRFNASTTSLHHEPTGTGRTSPSKSSLKSNTSVKRPVEPTTPESSTARSIKRLREALSPKRQRPRTPGQSPRVKTLPPPPLRAEDLDSIIKSLQHAHSQSGTALSALEQWKGKHEEDAKAHADLVHRLTELEGSKVRMEQILQTTQIELEAKRIALKRARVSVNEMESLKGRLSDAQETIVALRSQLEQVGEVARRSTENTDRQVFVLEQELDRVRHERVREVERLRTENDMFRKRAEESEFGQNALREGGARLQREVERRDREIEALRKGLARGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR05</accession>
    <name>A0A1Y2AR05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_561295</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR05"/>
    <dbReference type="FunCoup" id="A0A1Y2AR05">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AR05"/>
    <dbReference type="InParanoid" id="A0A1Y2AR05"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY24971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="139" mass="15534" checksum="E8E7D9CE3B65228A" modified="2017-08-30" version="1">MIPSLSRVVRRAPIILRPAYTSVRLNSGGPGAHAHETESYEAFNSRYQQFFASCSDLFELQRGLNNCFAYDLVPSVEVIDAALKCARRVNDYATAVRILEGISVKVENKGQYKSYLEELKPVLSELGVSSKEELYGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARQ8</accession>
    <name>A0A1Y2ARQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_292189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARQ8"/>
    <dbReference type="InParanoid" id="A0A1Y2ARQ8"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="243" mass="25239" checksum="33A8C84CE2C31979" modified="2017-08-30" version="1">MGSGASKSARRLPTTIPTTIRSTTIPTPTPTPAPAPTPASTPAGPYDPIASAHPPASAGDVGGSDAVMSQYGGRGQDGGDASVPGRSRPGFSGEKDAAVLRDGMDPQFASNLSRLGQVAIHDAGLFMRTPSAAQRTLSARQQASSSSSSSSTSSSTSQNQQQLLTTTLLISLLDNLKELPPGSDPTHLYKKFGVDQSLIGEVRKWVNSPSIGDEIVLVDEGEEQKFLPAIWVDAADMAEKPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARX8</accession>
    <name>A0A1Y2ARX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_544301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARX8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARX8"/>
    <dbReference type="InParanoid" id="A0A1Y2ARX8"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="103"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="557" mass="61349" checksum="4A6952F1455D67E1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS38</accession>
    <name>A0A1Y2AS38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_544516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS38"/>
    <dbReference type="FunCoup" id="A0A1Y2AS38">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS38"/>
    <dbReference type="InParanoid" id="A0A1Y2AS38"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="10">
        <location>
            <begin position="89"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY25371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="162" mass="17513" checksum="6E7E88706AD05289" modified="2017-08-30" version="1">MAEDNKDDQHETFEQAGAGASSTYPMQCSGLRKGGHVVIKGRPCKIVDMSTSKTGKHGHAKVHLVAVDIFTGKKLEDISPSTHNMDVPNVSRNEYQLLNIADGFLNLMDPDGNSKDDVKVPDTDLGREIEAGFDDGKDLMVTIISAMDEEQAVSVKEAPQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASA3</accession>
    <name>A0A1Y2ASA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_561035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASA3"/>
    <dbReference type="InParanoid" id="A0A1Y2ASA3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="261"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="771" mass="87150" checksum="1A104EBC2EBEB8D7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASJ6</accession>
    <name>A0A1Y2ASJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_544078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASJ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASJ6"/>
    <dbReference type="InParanoid" id="A0A1Y2ASJ6"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="76"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="359" mass="40470" checksum="E9AE2EE0B918DB54" modified="2017-08-30" version="1">MSTTTTVTESTPVASEPTVLRLNAYTEENPLKYPRYLPVWEKSQTAPALEEDKDYVDPGTRGTPDKRHLLIPGTTIKSLTPNFGSEIKGVQLSALTKEGLDDLALLTAERGVLVFRDQDFKNIPIEQQAETVRHFGRLHVHPTEAHPEGYPSFRVVYRDPGDNTVTKNLRYGNPNKVDTVTSTLFHVDHSAEIQPPGITFFWALETPESGGDTIFSSQIAAYEALSDDFKKRLEGLEVVHDNSAQINNSKRAGGPVRFEPVIVNHPLVRTHPVTGKKSIYIHGFSQRIVGWKKEESDYLLQFLHDVIVKSVDFQVRASYDDNTVVVWDNRISSHSAIVDWQTHERRHMIRCAAHADRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASL6</accession>
    <name>A0A1Y2ASL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_545042</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASL6"/>
    <dbReference type="FunCoup" id="A0A1Y2ASL6">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASL6"/>
    <dbReference type="InParanoid" id="A0A1Y2ASL6"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY25197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="289" mass="31262" checksum="04471D76CE142656" modified="2017-08-30" version="1" fragment="single">MSTAIASASSHLISNATLIKQGAEAKVYSLLSLYPEPQIFWPESSSSTSSSSPSSSTTAGTTPVILKYRFPKQYRHPTLDSALTRSRLAFEARALTRCARAGVAVPRVLWVDEGGGVLGLEKVEGWSVREVLGGGAEGEIEVVEEEEEEQEGDAAEDVERLKLDDGDEDGLGQVESEGMIQLKRISVTQEHLMSSIGTALSRLHITTIIHGDLTTSNMMVRLTPGAAQPYEIVLIDFGLSSTAQVAENYAVDLYVLERAFASTHPQSEGLYAGVLESYARGMGEKRWQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASP0</accession>
    <name>A0A1Y2ASP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose-binding domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_590126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASP0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASP0"/>
    <dbReference type="InParanoid" id="A0A1Y2ASP0"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.10">
        <property type="entry name" value="alpha-amino acid ester hydrolase ( Helical cap domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="373"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="626" mass="69292" checksum="2854CD994B67A79B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT49</accession>
    <name>A0A1Y2AT49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_288545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT49"/>
    <dbReference type="STRING" id="71784.A0A1Y2AT49"/>
    <dbReference type="InParanoid" id="A0A1Y2AT49"/>
    <dbReference type="OrthoDB" id="2558704at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="17"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="389" mass="42674" checksum="1D22F9F9007F7D87" modified="2017-08-30" version="1">MPTEFISATFPNSSSELDPKPGSPLDPDFLVRYARTLDDNDFNYTLIPYGSSSFDPFTIGAAIAMVTKKLKLIIALRPNTMYPTVAAKQLATLDQISQGRAVVHFIAGGDDAEQQREGDFLGKDERYAREEEYIKILRRAWASSEPFDWEGKYYQFKDFRNSVLPVNGTIPVSVGGSSPEAYRIGGALADIFGLWGEPLKETKEQIDRIYAAADAAGRAPNDRPRIWVTFRPIVAETEDLAWAKAHRILDQLKANRAGFANIMPPSKTGPQNVGSQRLLEIATRGEVQDRALWYPTVTATGARGASTALVGSPQTIIDSILDYVDLGADLISIRGYDNFNDAVDYGRYIIPGVRKALKERSSNGDGANGKETNGTGVNGEDRATKRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATG2</accession>
    <name>A0A1Y2ATG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_566194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATG2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATG2"/>
    <dbReference type="InParanoid" id="A0A1Y2ATG2"/>
    <dbReference type="OrthoDB" id="2413468at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="508" mass="53803" checksum="73A6C50CC08B5B26" modified="2017-08-30" version="1">MLGGAIDAIGLIDSRDTPPPTVIEPSKKDGPSASDALGFSEDRHMSPPTFLQPSRTGRSDHSVGSLAPPSEVSDKSSVSPASLPSRGASLPTPSANPSLNLVMPPPLLSRRSAQSDILHKVSSSLSLRQNAQSQLTITNIAARPWPAAMLYGHIKNMKNPGDRAKGYAKAFNELARAETGIREWCIASDAQARRSVPRPVGKVATQQHSLGVRSESILSPKSHSHSLSVPDPSRLHSRNTSSSSEFPMRADSYTAREISQRAIDPDDQPTALPPNLPYPQLQPQFQTSGMKHSQSMQSVASSVTSKKSHERSFWGIRKSGNKKDSMSLSLGPANSGSAAKKDVRGLPISSPSLGTTSPQRTGGGGGGEGGLAAPRVQSSVSVPMGPRGPRMGSFTPPPNNNTYTDRSSFEQPGRASLDTGLSRMTITNTATATQQARGSLDNFASPLLPGQKSSPLAAGREDDLKSMADVLPHVERGVLRAYLGRYGDQMAAIGAYIEDEQRGTVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATY5</accession>
    <name>A0A1Y2ATY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_542595</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATY5"/>
    <dbReference type="FunCoup" id="A0A1Y2ATY5">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATY5"/>
    <dbReference type="InParanoid" id="A0A1Y2ATY5"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="272"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="174"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY25924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="338" mass="36706" checksum="19DA1511EF5C0A9B" modified="2017-08-30" version="1">MAAAVPLHVHPETFNAEEAAHVAAEFVSSLDNLPGEVTFLLEEIKDKDNRINHLLQRISNRHTGLTKSALKFSTVQPSGTTFPLPIPAGAPIPLDHLSTKDQQTLIKIQGEWAKVSALQDEKIRLAERLERIVARARVRGAAEWARVGGMGLDEVERENNVKLGGMGEMGAGELVLPPGGLGSGSDGRPMKKRRPNALPLPLPSTFSSPLGTQIHPSTSMPPPSFPTPSARGSLSGRAARHARHISNSPMSEPDADADGDADGDGEVEADNQLYCLCQQKSYGEMIGCDNDNCRYEWFHVKCVNITPPLPETWYCPDCVRKLGLSSSDGKRDKKGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU36</accession>
    <name>A0A1Y2AU36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mitochondrion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_274274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU36"/>
    <dbReference type="STRING" id="71784.A0A1Y2AU36"/>
    <dbReference type="InParanoid" id="A0A1Y2AU36"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="91"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="300" mass="32794" checksum="44DA39EFE9707698" modified="2017-08-30" version="1">MPAPTSDPTWSRLVRFIPSPTIDDPVPGPTLGEPVDVAIDVGLAYHEGVMIEVWLLYGDPQRPWTAGRRTGEKRVVAHLLCPVSNEICGTIRATGLSYKDHAAELNMPLPAVPSVFFKPSTSLANPSETIHIPLEAQNEEMDYEVELAIVLSRTCKDVSENEALSYVLGWTCANDLTARKVQATSSQWGYSKGFDKFLPLGPVLVSPRALPDPHIVALQTYLNGQLMQDGSAKKMIFPLSKVISYLSQGTTLPAGTVIITGTPPGIGDGRTPKVWLKHNDEVRCWISHGIGTLINRIEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU43</accession>
    <name>A0A1Y2AU43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_277857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU43"/>
    <dbReference type="FunCoup" id="A0A1Y2AU43">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AU43"/>
    <dbReference type="InParanoid" id="A0A1Y2AU43"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="237"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="339" mass="36820" checksum="12F2C1015009085F" modified="2017-08-30" version="1">MALVLEKPGESSTAISEKRQTIPLYLVNGVATVWDAQVAATLHCDHAISGLRVGTLPGVSQQNGFLGLPITLMQEETAYLVRSGIAHIVPVATDPYALVPSPEQVAAHTAARKERIKRIEAQLQAAAQNKERNRQQAFEKGGEKARLKREARARVKAEKAKSTESSLFEGEGQSTSLPDRPASATSPDKTAPSSNGHFYAFSALPAYPDLSLSAPITSVPHPLFPFPITPRHCALLGVFSALQARGYRTGLGPRFGGEYLVYPGDYLRYHAHFTSQVIVRDEPIKPGELVAWGRLGTGTKKAGLLCCWDDGVRPIDTEIGDEEKEGDVEFYSLEWANFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUA0</accession>
    <name>A0A1Y2AUA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BCR39DRAFT_542069</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUA0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUA0"/>
    <dbReference type="InParanoid" id="A0A1Y2AUA0"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="24">
        <location>
            <begin position="122"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="60"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ORY26168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="509" mass="55709" checksum="0C356F310CACE3D5" modified="2017-08-30" version="1">MTQQKQIDGKQVAEHNDRDKGVWIVVHGHVYDVTDFLDEHPGGAEIILRYAGMDATEEYEPIHPPDAIKDNLDPSKHIGQLIPNSLPKPQAASPAPPPASISVPQKTTSATGEPVAEEYVKPPLEEILSLHDFEAVARRTMSRRGWNYYSSGADDEITMRENHNAYHRLWFRPRILRNVGVVDFSTEILGYKSSMPVYITATALGKLGHPEGEVCLTRAAAEHNIIQMIPTLASCSFDEMVDAASPGQIQFMQLYVNSDRSRTNKIILHAKERGVKALFITVDAPQLGRREKDMRTKFEGTASAQQATGKDNFRRDQGAARAISSFIDPSLNWTDLGELMEAAKGMKVILKGVQCWEDAVRAAEAGCDGVVLSNHGGRQLDFAPSPLAILPSVVSALQSRGFMSRHPSQPKFEIFVDGGVRRATDVLKAVALGATAVGIGRPMIYAMSTYGQEGVSKALQILKDEFEMNMRLLGAPTMADVVPSMVDTSALHAPSGEVTMYDENCESAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUA6</accession>
    <name>A0A1Y2AUA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TFIIH p62 subunit, N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_542095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUA6"/>
    <dbReference type="FunCoup" id="A0A1Y2AUA6">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUA6"/>
    <dbReference type="InParanoid" id="A0A1Y2AUA6"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="239"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY26173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="632" mass="69516" checksum="ED686A5EA9CDB852" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUB1</accession>
    <name>A0A1Y2AUB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MT-A70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_541996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUB1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUB1"/>
    <dbReference type="InParanoid" id="A0A1Y2AUB1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="525" mass="57952" checksum="8CD54A48A5B60A0E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVF0</accession>
    <name>A0A1Y2AVF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_540594</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVF0"/>
    <dbReference type="FunCoup" id="A0A1Y2AVF0">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVF0"/>
    <dbReference type="InParanoid" id="A0A1Y2AVF0"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="352"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="568"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="796"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="805"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY26573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="854" mass="96171" checksum="DC646A81E273F05A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVW7</accession>
    <name>A0A1Y2AVW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_540565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVW7"/>
    <dbReference type="FunCoup" id="A0A1Y2AVW7">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVW7"/>
    <dbReference type="InParanoid" id="A0A1Y2AVW7"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="165" mass="18202" checksum="4426029A1527F052" modified="2017-08-30" version="1">MSGRGFSRGGGGDRGGRGGFRGGARGGRGGFQRDFGPPDTVQEIGSFMHPVESEMLCTLTQPTRIPYFNAPIYLANKTQIGKVDEILGPINEVFFTVKMDAGVQAGSFHKEDKVYIGGDKLLPIDRFLPKPKVAGAKPESEFKFYISLNSIDRERSNWERDKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX29</accession>
    <name>A0A1Y2AX29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_578347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY27004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX29"/>
    <dbReference type="InParanoid" id="A0A1Y2AX29"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="494" mass="54761" checksum="5E6AD2A4CEB2F1BC" modified="2017-08-30" version="1">MPELEKHEDTRLEDASGVVHEKPEDIELSRDEGLIDKKAERKLLLKLDLAILPMTVLMYLSANLDRGNIGNARLQGLQAELLSGSDSKYSVVLLSFYITYMLFSIPGTLLSKMVPPNYALGAGCLIWAVAASCMASCQSYAGIIVCRLFIGVGESIFGQAVVLHYSLWYKKNEIATRLAAFIGAGVLAGAFGGLIAYGVSHIKSHIETWRILFLIEGCPSVVLGICVCLFLPSRPDRSKYLTETERELEFLRLRSQNLDEGNNGIDWNGVKRGFTDWKSYVVTFIYSCMQLSLSSLSGFFPTIIKSLGYTNAEAQLYTVPPYAVGFVFMILVNFASDRTRLRGPFIILVFFINVLGFVLLITVVSNEHARYFACFCIVIGGYCTIPLIQSWVSNNSGSQSQRAVHLGMLNSLANWAALTSPFIFPSSAAPTWHLGFGLNLGFSCAAILVTTIMILYYRYENSRRDEVEGGRPLQGQKVEQARLHDLAPGFRYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXB4</accession>
    <name>A0A1Y2AXB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_539023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXB4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXB4"/>
    <dbReference type="InParanoid" id="A0A1Y2AXB4"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="174" mass="17933" checksum="A7BFDBF7A295D2C3" modified="2017-08-30" version="1">MSDFLNQAKAAATSALNTASDLASQAATQASALASQAANSQAAATATEQAKHLGAQAYTAAGNLAGQAHAGAHNLAPTVIPAPAEGVDKSHTLEPSSPVETAKFEKLFQARPDHTKLQEEGILKGPPGDQLAGKRAELLESMKKDKLDKDIAQRPQPEELVKKGILSPDDAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY15</accession>
    <name>A0A1Y2AY15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_538122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY15"/>
    <dbReference type="STRING" id="71784.A0A1Y2AY15"/>
    <dbReference type="InParanoid" id="A0A1Y2AY15"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000081">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011816859" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="117"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY27461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="398" mass="45466" checksum="450FD768D304FFA2" modified="2017-08-30" version="1">MTFSPCRLLRLSLYLVIPVVFLLSEVVAERDHFQTRDFQTLSAESLRELVDLDPPQWTSTDEGHLSKLLIPRASGSENNTLVQEYISSIFSELGWHEETTPFTGETPIGPVEFTNRIYTFDPEAPRRIVLAAHFDSKWFPDYPANQFIGATDSAAPCAMLLDLAQSLTPLLRKRKERLVSGMGQLRDGFDEEEAGETTLTILFLDGEEAFHDWTATDSIYGARHLAELWDSTYLSPSHPLSVSKRRFAPLATQLNTIDHLVLLDLLGNSHSRIFSYFRETDWLHAKMAHADERLRREELVEVEQGQENWFGWIKMHKGMIEDDHVPFLDRGVSILHVISNPFPPVWHTLKDDATALSMPAMRRWNRILRIFTAEYLGLSPEKDKKPPSRSGDELPRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B093</accession>
    <name>A0A1Y2B093_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_536762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B093"/>
    <dbReference type="InParanoid" id="A0A1Y2B093"/>
    <dbReference type="OrthoDB" id="3429435at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF1">
        <property type="entry name" value="ESTER CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="384" mass="43497" checksum="F6FF00A1B0DB8757" modified="2017-08-30" version="1">MPDANFHSGSSAGTPSESSAHSSVVQVERLDYIDLVSSKRSRAHPMDGFDDTYTDIVDYIVRCTHRIWEERDIGLIYTHYTHNSIMYGTMATLYDREQVVRDTIQSLVTCPERRITATQVIWDGNDQEGFYTSHLVVNAGHHTQHGHLGPPTGRSFASRTIADCMVYRNRIYREWVVFDNMAILKQLGIDPNPIAEKAARALFEKGLVSVDVGENGRCLGQYPPESEPDLSLAHNEVEKDTLRWLHEVFNKRMLGHIRKIYSPQCQYHGPRMTELYGIAAVIHQHLGLIGSIPDAAYMPQRICSLPSEEGGVKLSVRWIIEGHHLGYGLLADLGPPSGQRLQVMGITHYHYKNSRIIEEWNVYDEVALLMQVKLGKMVEEARSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1P4</accession>
    <name>A0A1Y2B1P4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GLTSCR protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_533746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1P4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1P4"/>
    <dbReference type="InParanoid" id="A0A1Y2B1P4"/>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="50721" checksum="DE7D606CD8828D2B" modified="2017-08-30" version="1">MSTVDHGQQTPKTSSTPLNPSIVVPSPLTPTQSSQLTPNNISSSRPSHSLPTTSNKSYPLPPIPSSSSSSSSYPIPSSTTTTTTSRPIASTATSRPVPSTTSTTSRPVPSVPTSSISTSHQQPSSNKRKRPDLTPDESLIASERSTTLALALAQDQLDTLYPSPEALDRFKNLNDAVARLVPWHLWSYGEGEGELEGSGERAKKAQERDLAESADLLRRMATVNKRFLAVRQREGRHPSPLPVLISLINDSTASVRSEIGVLGARVSAAKAQYEGLESRRREGERVRVEMQRRKEEAEAAAVAAALERGKPRGRPRGRGGRPGANLPVVTHASSAAATKPPSQAPQGPVQITVALGILPQLVQVGVLNKTNVGANKTPGQVIRATEDKKSAVLSIHLGACTPPQLATLAKLLNVKAASDESSKATPPGTPSTSTSDKAQSAPARGQNAPNKPDDTSNKPQGNGDTGQTTQSTPNGRTRSAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1W8</accession>
    <name>A0A1Y2B1W8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_533947</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1W8"/>
    <dbReference type="FunCoup" id="A0A1Y2B1W8">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1W8"/>
    <dbReference type="InParanoid" id="A0A1Y2B1W8"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY28803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="301" mass="32562" checksum="A75CC5A604609E54" modified="2017-08-30" version="1">MDALASSLSAPPRLTRDLNEDGDDAGSSAEWGSQGGFGNLHSGFVGGMTVPRTPDPAAFLNLHTDSMSSNPQAKIKLAHGTTTLAFRFKGGIIVAVDSRATAGSYIASGTVKKVIEINPYLLGTMAGGAADCQYWETYLGMQCRLHELRNKERISVAAASKILSNIVYQYKGMGLSMGTMICGWDKTGPALFYVDSEGQRLKGDLFSVGSGSTFAYGVLDQGYKFDLTDEEAQDLGRRSICAAGHRDAFSGNTINLYHVKEHGWDFIGNYDLSETWYEYTQKEKGDKMTRVEAPSPMAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1X7</accession>
    <name>A0A1Y2B1X7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_534961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1X7"/>
    <dbReference type="FunCoup" id="A0A1Y2B1X7">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1X7"/>
    <dbReference type="InParanoid" id="A0A1Y2B1X7"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="151" mass="16984" checksum="E668E7375F2258C8" modified="2017-08-30" version="1">MGRMHSKGKGISASALPYRRSQPSWSKATPEEVSDQIFKLARRGLSPSQIGVILRDSHGIPQVKGVTGNKILRILKTNGLGPSIPEDIYHLIKKAVSVRKHLERNRADKDAKFRMILIESRIHRLARYYIKKQQLPPTFKYEAATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3Q9</accession>
    <name>A0A1Y2B3Q9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_532563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3Q9"/>
    <dbReference type="FunCoup" id="A0A1Y2B3Q9">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3Q9"/>
    <dbReference type="InParanoid" id="A0A1Y2B3Q9"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="265" mass="28006" checksum="54B9B5366120D02E" modified="2017-08-30" version="1">MSVTPDYTINVAGLAAETTEEKLHDFFSFCGKLVSVKKTGSTATIQFEKLSAMRTSLMLNGGTLDGAHLEVTAANDVETKTPSVLPTGATGSTPIGASGEISQEDKPKAAIIAEYLAHGYVLGDHVVQRAIDFDHKQGISNRFLSFFTGLDHTVGEKVVGEDKTISGKLQEAGAAVYAKTREVDQKGGVSAKFAEYYNKVVGTPVGQKVHSFYTSTQKQVLDVHEEARRIAAEKKAAETGATGDVKTAETATPTTAPLVSAVAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B493</accession>
    <name>A0A1Y2B493_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alginate lyase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_575017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B493"/>
    <dbReference type="STRING" id="71784.A0A1Y2B493"/>
    <dbReference type="InParanoid" id="A0A1Y2B493"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011002863" evidence="6">
        <location>
            <begin position="21"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="7">
        <location>
            <begin position="233"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="569"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="799" mass="85959" checksum="6F03F3BC8FA90318" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4B7</accession>
    <name>A0A1Y2B4B7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4B7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4B7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4B7"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF5">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="110" mass="12159" checksum="CA32E31283864034" modified="2017-08-30" version="1">MADAQTAILLEDKILAKAMTSDLEKVEGNWYFKEAALIDRSKYSASNTHTTCPWKGVASYYNYTTDEGKEIKDIAWFYPHPKAGAEQVAGRVAFYVGKVPGLKVGVPPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4K3</accession>
    <name>A0A1Y2B4K3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">beta-glucosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_530965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 7"/>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4K3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4K3"/>
    <dbReference type="InParanoid" id="A0A1Y2B4K3"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="8">
        <location>
            <begin position="418"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="863" mass="94572" checksum="9E7AA6517381A029" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4R3</accession>
    <name>A0A1Y2B4R3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_163672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4R3"/>
    <dbReference type="InParanoid" id="A0A1Y2B4R3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="260" mass="28494" checksum="F00F9A71C4429486" modified="2017-08-30" version="1">MSRDSSTSSRSSPHPTVSELPPQASLTAFDPDGSLQLDTDSQGILYIPSFLNPHTTFAELPFHEPPPSGSTIPATGEGTDQSGAYTPNTRRMADLGARTDRLLRQYFATSLAMMDLTQPDLTDWDKEQSIQDLERLKTTARETATSLNQMKIVLFNTADESGQVVPSVFCAWKHGDQVEDSFNGLEAFLAFRDMYADASLVNSWGDAPTVPFEGSGMPTREQIEYDLALRRAVHDPYALASIPHVDPTTLTGVGSIHHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4X7</accession>
    <name>A0A1Y2B4X7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_532887</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2B4X7">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4X7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4X7"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="MARCHF6-like_C"/>
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    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="862"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1151"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1245"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1288"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1341"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="422"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
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        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY29145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1445" mass="160837" checksum="F6585D198C44E02D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B550</accession>
    <name>A0A1Y2B550_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_588260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORY29680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
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            <end position="222"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="367" mass="39084" checksum="75D41C59900F556F" modified="2017-08-30" version="1">MPTDAPPSYETVAHNPELNVTDPTGHTDLPRTASQSDTQHPFQRSQSNSSISTVSSSGLGADDLVGDEGRRSMDDEARELPPGWVRCFDPKTEHHFYVDESTKRATWLHPYDDPEYLRTLPDTHPANPNSVEAQAMRKRAEDEALLAKRIQESDAKGSKKAAGHGADTSAVDDGMVVQNTKAAGGDRNWLQRQKDKLVGTKEERAQAKEQRRKQREEERKRMKEAQEAYMKRRQELLKKQLNDPNIRAMYASDPYRYAAPSMAYTRSGGLYDSPYGYGYNGGYGRRYGYGYGGMGGGMGIGMPLMGGMAGGLLLGDMMSGGLGGGGFGGGFGGGGFGGGGFDGGMGGGFGGGGFDGGGGMGGGGGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B608</accession>
    <name>A0A1Y2B608_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bud-site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_532022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B608"/>
    <dbReference type="FunCoup" id="A0A1Y2B608">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B608"/>
    <dbReference type="InParanoid" id="A0A1Y2B608"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="82"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="515" mass="55718" checksum="5DB9310AADE69E16" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6F1</accession>
    <name>A0A1Y2B6F1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_529782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6F1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6F1"/>
    <dbReference type="InParanoid" id="A0A1Y2B6F1"/>
    <dbReference type="OrthoDB" id="2591449at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="755" mass="81414" checksum="E32B0368FA81A63A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7F9</accession>
    <name>A0A1Y2B7F9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_529770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7F9"/>
    <dbReference type="InParanoid" id="A0A1Y2B7F9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="72"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY30407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="554" mass="61533" checksum="F60E1E6D73FA04D1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8U5</accession>
    <name>A0A1Y2B8U5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_494026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8U5"/>
    <dbReference type="FunCoup" id="A0A1Y2B8U5">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8U5"/>
    <dbReference type="InParanoid" id="A0A1Y2B8U5"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="72"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="128"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="335" mass="36198" checksum="3597F74FB4350C75" modified="2017-08-30" version="1">MSQPKVLICANPKNGIVWSKAEQSSKLGAVAQVIEFSEPDRKSFFDACKPGAKYDGVVGIYRHNDSASAIGVFDKELIEALPESVKYICHNGAGYDQIDVEACTKRGIQVSHTPQAVDDATATVGAYLTISALRQFHRAEVNLRNGKWKAGLSPASDPEGKVVGIIGMGGIGSAMARRLLGFDMKIIYYNRKEISPRPDFPCTYISSLDDLLAQADVVSLNLPLNDKTKGSFGKREFGLMKQGSVLVNTARGAVVDEEAFIEALESGKLASAGIDVYPDEPNVNPKLVAMDNITLLPHMGTETRDTQKKMEILVLDNLISAVSGKGLLTQIPEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B993</accession>
    <name>A0A1Y2B993_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP12-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_527206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B993"/>
    <dbReference type="FunCoup" id="A0A1Y2B993">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B993"/>
    <dbReference type="InParanoid" id="A0A1Y2B993"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32492" checksum="A9094C263A5166AD" modified="2017-08-30" version="1">MNTLTRSSRLLCPRCSRLAPVYIPSRRFTAQSVLRAQVAPGPALSQTNRAEITLRRFWKTVHIKREEDGTYQITLDHRNLKTPSGALLRVPPQRRLLALLVAHEWDNQDEVLKQHALPLTSLASRAIDGLSNDQTRQRVIDDLLRYLETDTICFPSDRPDALVRLQKEHWDPLHQWLKDEYGVQLVLAEGFAPARQSEETVKVLRGLVEKMDNFELAAFERAAYASKSFVIALALCTGRLSADAAAHAAHVEVTSQIEKWGEVEDTHDVDHHDIRRSLGSAACALVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA30</accession>
    <name>A0A1Y2BA30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA30"/>
    <dbReference type="InParanoid" id="A0A1Y2BA30"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="249" mass="27108" checksum="C536F7175D2B3405" modified="2017-08-30" version="1">MAGRRGTEIDKDKEHELEDEDVHKDKSTDGDGWTGQVPKLILSSETTIHSLSLTSVPISPSPSPTSPSPSSTHDLNDASRPPRSMPRRSSIPLGPPTSTQVSPSHDTLRSSLSDTDTDTIPSPISVAISSTSRISDSISSLQQNTTTLLTILSNLQTSAMALSSGSGTSRSLRGIKASIDSFREREAVEVRARKIIEQWESQRLRAGLGLTAKLARPVLQDECQAFKIVLDDCQRRFENIIQRPQVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAX6</accession>
    <name>A0A1Y2BAX6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_465186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAX6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAX6"/>
    <dbReference type="InParanoid" id="A0A1Y2BAX6"/>
    <dbReference type="OrthoDB" id="3363836at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="650" mass="67826" checksum="0897BF2EE67E06C0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB89</accession>
    <name>A0A1Y2BB89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_524145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB89"/>
    <dbReference type="STRING" id="71784.A0A1Y2BB89"/>
    <dbReference type="InParanoid" id="A0A1Y2BB89"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="622" mass="66989" checksum="793245EADBB6F00C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBV8</accession>
    <name>A0A1Y2BBV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_523879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBV8"/>
    <dbReference type="InParanoid" id="A0A1Y2BBV8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="178" mass="19336" checksum="325F47D22097382D" modified="2017-08-30" version="1">MSQSSVTSKSHATLSKGVNADVQRASFFPVDPRCMCIPYGQRYKQEYGNEIAPSPTTPHLRLTSPRTVKSTSHSLLENLKSQLTTMTPAVDCHRYPEVGVQRSLEESHEGPFSISHSGGPPDLRSGVFGVTSERLALWSRNGLERGLTITVGLSGDGWTGKLDDVWAFESALESGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCP3</accession>
    <name>A0A1Y2BCP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_375602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCP3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCP3"/>
    <dbReference type="InParanoid" id="A0A1Y2BCP3"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000008">
        <property type="entry name" value="alpha-centractin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY32524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="377" mass="42060" checksum="15132931BAE4B637" modified="2017-08-30" version="1">MATEFDDVLTNQPVVIDNGSGMIKAGFAGEEQPSCYIPSFVGRPKHPRIMAGAIQDNLFIGRRAQELRGLLKIKYPMEHGVVVDWDDMERIWGWVYAEGLKALSEEHPVLLTEAPLNPRQNRDVAAQVFFETFNVPAFFTSVQAVLSLYSSGRTTGIVLDSGDGVTHAVPVFEGFSMPHAIRRIDIAGRDVTDHLQLLLRKSGYYLHTSAEKEVVRTIKEKTCYLALNPAKEEKDNGGAWEEFRLPDGKVIQLGAERFLAPEILFNPELIGQEDPGVHQVIVDSINRTDLDLRKSLFSNIVLSGGSTLCTGFGDRLLNEVKKLALKDVKLKIYAPPERKYSTWIGGSILAGLSTFKKMWVSADEYKEDPDIIHKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCQ6</accession>
    <name>A0A1Y2BCQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative COPII-coated vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_523132</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCQ6"/>
    <dbReference type="FunCoup" id="A0A1Y2BCQ6">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BCQ6"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013163967" evidence="9">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="200" mass="22693" checksum="27DAB2C8CDA4D83A" modified="2017-08-30" version="1">MILRSLSFSALVLAFLTLCSAHRIEIDPGGKECFFETLQPQDRMTVTYEVGGSTGGGHLDIDFFVTEPSGDTIYTSFKEPQGTFSLAADRSGKYTYCFSNEMSSYSRKVLSFNVHGVLYVGDDEHIAPVEQEIRDLSSGLQLVKDEQAYLVVRERVHRNTAESTNSRVKWWAIVQTIILFSLCAWNVHYLKSWFEVKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDC3</accession>
    <name>A0A1Y2BDC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_522706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDC3"/>
    <dbReference type="FunCoup" id="A0A1Y2BDC3">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDC3"/>
    <dbReference type="InParanoid" id="A0A1Y2BDC3"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="250" mass="27858" checksum="00D5FA32FA61FE73" modified="2017-08-30" version="1">MATSSQISKKRKFVADGVFHAELGEFFTRELAEEGYSGCEVRVTHARTEIIIRATHTQEVLGDKGRRIRELKALVEKRFKFPENSLELYAEKVQFRGLSAVAQAESLRYKLLGGLAMRRACYGVLRFVMESGAKGCEVVVSGKLRAARAKSMKFTDGFMVHSGQPARDYVDYAVRHVLLRQGVLGIKVKIMKPFDPEGKMGPAKNLPDVVNMVEPKPEGVIEIRSEHKDPPVQPIAQAAAPQEAPQQSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDI0</accession>
    <name>A0A1Y2BDI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_522329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDI0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDI0"/>
    <dbReference type="InParanoid" id="A0A1Y2BDI0"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF7">
        <property type="entry name" value="PROTEIN STB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="669" mass="75145" checksum="3E4554410A9E2FEE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDK7</accession>
    <name>A0A1Y2BDK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_464417</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDK7"/>
    <dbReference type="FunCoup" id="A0A1Y2BDK7">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDK7"/>
    <dbReference type="InParanoid" id="A0A1Y2BDK7"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="950"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY32630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1155" mass="125834" checksum="43F4B9E1D55356AA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE90</accession>
    <name>A0A1Y2BE90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_521437</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE90"/>
    <dbReference type="FunCoup" id="A0A1Y2BE90">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE90"/>
    <dbReference type="InParanoid" id="A0A1Y2BE90"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="183"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="413"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="543" mass="58647" checksum="7062D8700EF1F215" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGF3</accession>
    <name>A0A1Y2BGF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Foie gras liver health family 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_519278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGF3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGF3"/>
    <dbReference type="InParanoid" id="A0A1Y2BGF3"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055428">
        <property type="entry name" value="TRAPPC13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23643">
        <property type="entry name" value="TRAPPC13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="407"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 C-terminal" evidence="3">
        <location>
            <begin position="1141"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1253" mass="136943" checksum="82E65372E6830279" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGS3</accession>
    <name>A0A1Y2BGS3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_232913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGS3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGS3"/>
    <dbReference type="InParanoid" id="A0A1Y2BGS3"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118845" evidence="13">
        <location>
            <begin position="19"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="342"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY34011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="468" mass="50013" checksum="BCA818436A824829" modified="2017-08-30" version="1">MIAVRAFVVTTLIAVASAHIALWDEGMYGWTDDPNQNNLVTPLANLTFSEWWFHGQIDSPPPDGKVMNLPSGGTYHGQVACNKALTTYGQNPAQQTGLYACDGTGPQGGIGAMHTSDAWESPDPKDVKGCGIAIAYESDVSKIKPEDFAVISVNYTCPWFKHVDFEIPSDLPACPEGGCHCMWGWIHSADSGSEQMYFVGYRCNVTGATGTTPIPQTKTANKCDYPTDTSNCTIGAKSPHYWLQAEGNNNFQGTYDPPFYNGAYGYMNGAQTDLFAGESYTMSTETPSTSSSVALLSASSSPVSNTVSSSQPLAATLTGSPTLTTSAVLSSLSDAAALASPQTSSTSSTFPPSLSSSNDPALPNATVAANSTVSPPGSNVTSATASASSNLTKQCKRRRSPSARALQHLASHPEYIKRHDDLNLRLRRKRTNKAQKRGIEPNLTMRKRRSRQASSRLSFDRHTGPRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHJ0</accession>
    <name>A0A1Y2BHJ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_517252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHJ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BHJ0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="23643" checksum="FB9319555B5483D2" modified="2017-08-30" version="1">MDSVIPIPQETRNNAAQETGNVVPQDTRHFVPAPTPPPNIPLPPIPLHPSPALSLSRISSAPHHASFPASVSPTIRTSPAESASTRSVYRARNPMPTQNRPSRVNSLTKRPLPPSPTTSTSSVMFDLDPDPFAAPPLPETVSMSTQTQTQARGAQVPYSYSHHPTLTRLERQHAAWKKSREDLGRVQMVIGEAQGRVLTPPPMYSIEFDSEESGRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHM2</accession>
    <name>A0A1Y2BHM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatases II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_477537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHM2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHM2"/>
    <dbReference type="InParanoid" id="A0A1Y2BHM2"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="197" mass="22145" checksum="574EE396769B46CB" modified="2017-08-30" version="1">MRREAQLIIPGLWLGPFQSSTDLRRMHSMGITHVLCIRDKREAALIYPRFPTEFRYMTIEISDTADQKLINILSDSKAFIDEALSSGGTVLAHCNGGISLSPAIVIGYLMTISKATWEDALAYVQSRRYCVAPSSFQIQLQEYEPIVRATQKILPGTSLGNGERKRSMSLDDQEEDTDDRARIAPSLRREGSDMDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BID3</accession>
    <name>A0A1Y2BID3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrion organization and biogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_517756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BID3"/>
    <dbReference type="FunCoup" id="A0A1Y2BID3">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BID3"/>
    <dbReference type="InParanoid" id="A0A1Y2BID3"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="682" mass="76026" checksum="48539FCFC708475E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ01</accession>
    <name>A0A1Y2BJ01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chromatin remodeling-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_573186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ01"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ01">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ01"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ01"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="222"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="449" mass="50705" checksum="E6D5267857A3DE66" modified="2017-08-30" version="1">MAQPTPGPSQPPATPAQGSVDIKRRAEAEADVSRRIKHQRAPLPPPHVLATLVPDSPAFNDLMKVEQKLDWTLLRKKAEINDALGRPVRVKRSLRVFISNTAHHQTWQDDASGRSQEQNGDSTQNVDVNTGKGIPGWVLRVEGRLLDSGNVRLDKTKRKFSSFLRSVVVEFDNREPPTYPEGNIVEWHPQTLQAPLDGFEVLRRGDTNVNCRIILHVAHFPERFRVLAPLDGLISMKEGTRADVMAAVWKFIKVVGAQDKEDGTIIRPVGGMEKIMPPGQEGVAFHQLPELVTRFLNHPQPVVIPYTIRVDQDFNLHDKCFDIPIEIDDPLKSKMAYIVQSFEGEEGREIVKLEDKVGELAYFARDLKQKRDFLEAFAAEPYTFIQNWLAAQARDLDQMLGFQIGVAGPNGGSVREEDLRRSDVFQMPWVDEAITVHESTRMEAERRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJH6</accession>
    <name>A0A1Y2BJH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_514465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BJH6">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJH6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJH6"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1349"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1607"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1717"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1469"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1569"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1808" mass="200959" checksum="BBF630E25CEA0804" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJN2</accession>
    <name>A0A1Y2BJN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_517786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJN2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJN2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJN2"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="52"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="206"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="336" mass="37137" checksum="545AC3FE541DC18C" modified="2017-08-30" version="1">MIRISRSLQKPTTSFKAAFTMSTTSTAPLAESSRTVVKSVYAQEVAEGVGATVRRSLGSGQLRNLSPFLMLDQFKASRGSGFPDHPHRGQSTITYVLQGYIQHEDFVGNTGFLGPGDVQWMTAGRGIMHSEMPYWDPDPEKAVDPEGLQLWVDLPADKKFIEPSYQEKKAKDITTIDPKPGVQITIISGESHGATGFVRPVGGCWYFDFRLSEPGAEVFQPIPEGWTSFVYLIDGPLQLESSDKVYTKHHTLVLSSSPSQTGVLLRRPASAGPDEPTTRFILVAGQPLDQEVRQMGPFVLNTERQVREAIMDFRMGRNGFERAPGWKSEIGKAMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJQ4</accession>
    <name>A0A1Y2BJQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lethal giant larvae like, C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_516015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BJQ4">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJQ4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJQ4"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="763"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1189"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1227"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1313" mass="142855" checksum="A371EFA2D031E7F2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJU1</accession>
    <name>A0A1Y2BJU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_596860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJU1"/>
    <dbReference type="InParanoid" id="A0A1Y2BJU1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="230" mass="25474" checksum="986CDCB04E860D8E" modified="2017-08-30" version="1">MSSFLETSDEQGNSFACTQVGNDHGAIVANIAALSTWADNGNSHPNFVIVLAKYIEKITTLCQESDTYALMSNGDIHTCVLFSRDIFDAHHGSVVPFSSNVSDGPYIDWYFDPNDIGSSNSFQTALFRPTEKDNDTIRVLRRFPTMAEVAIKSILWPDNMTFLERAATFRAVIKTHEGSMEMKDTKGMEKKGDTGVGEEMHSMPTTKTTVDLTITIWSVDPDSNQTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BK23</accession>
    <name>A0A1Y2BK23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_515789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BK23"/>
    <dbReference type="FunCoup" id="A0A1Y2BK23">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BK23"/>
    <dbReference type="InParanoid" id="A0A1Y2BK23"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="83"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="289" mass="32961" checksum="D2C77CCEA1A5EAAD" modified="2017-08-30" version="1">MLRRQTRERREYIFKKSQEAQEQAIYERKQRIKDLLAAGKSLPTELRNEARELGGKDLVLDEAQAAPKSHVDDEYAKVGTYDPKIVITTSRSPSSRLLQFSKELRLVFPNSFRLNRGNTVMRDLVQACLAQSVTDLLLVHETRGVPDALIISHLPHGPTLSMTLHNVTLRHDVSSNASSTVSEQYPHLIFDGFTTQLGSRVEGILKALFPVPKDDAKRVMTFANDRDFISFRHHVFAKASHKDVQLAEVGPRFEAKPYEIKQGTIDQTEADVEWLLRPYMRTAKKRNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKN2</accession>
    <name>A0A1Y2BKN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_508851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKN2"/>
    <dbReference type="FunCoup" id="A0A1Y2BKN2">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKN2"/>
    <dbReference type="InParanoid" id="A0A1Y2BKN2"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="226" mass="25050" checksum="1531C43C489F1C29" modified="2017-08-30" version="1">MANPRQRNKARSGKSTKPSQAAIRRMHHKLRKAPPMKGPAVLAANWDKTKTVFQNYAALGLLSSIPVPSGPSSSRTHRTTLPFLPDHMKSSTSQKTDESSLIVGYGRIIRDEQGNVVDIVLPEDEASQDGDIAMEDDDEEEEEKEERVVEGKTDVVRSLESLAASAQPIKRHTSSSERTWLQNLVAAHGEDYAAMALDRRGNVWQKTQGEIKRMVRKAGGREKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKQ4</accession>
    <name>A0A1Y2BKQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_513966</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKQ4"/>
    <dbReference type="FunCoup" id="A0A1Y2BKQ4">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKQ4"/>
    <dbReference type="InParanoid" id="A0A1Y2BKQ4"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="170"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="32"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY34675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="340" mass="35803" checksum="6B5E3B2C6F7B4494" modified="2017-08-30" version="1">MFSRNVARQASSIARRGFASSARAERKVAVLGAGGGIGQPMSLLLKADPLVTSLSLYDVRGAPGVAADVSHVNTASEVKGFEKDDIKSALTGAEIVVIPAGVPRKPGMTRDDLFNTNASIVQTLAEACAEYCPKAFICIISNPVNSTVPIFAEVYKNKGVYDEKRIFGVTTLDVVRSSKFLAEIKGVDPKDVKVTVVGGHSGVTIVPLLSQTPQGKDVTGEQYKALVKRIQFGGDEVVQAKAGAGSATLSMGFAGARFTNSLIRALNGEKGVIEPTFVKSPVYASEGVEYFATNVELGPNGAEKILPIGEVSAEEEELLKACIAELPKNIKKGVEFVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKR4</accession>
    <name>A0A1Y2BKR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_508937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKR4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKR4"/>
    <dbReference type="InParanoid" id="A0A1Y2BKR4"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="679"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="913" mass="99058" checksum="D10CA0C12971F6B5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKS8</accession>
    <name>A0A1Y2BKS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_591902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="SSSCA1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537:SF1">
        <property type="entry name" value="PROTEIN ZNRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537">
        <property type="entry name" value="SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="318" mass="34728" checksum="EFCFCC152A65495A" modified="2017-08-30" version="1">MPAPRMSSQLDQTSAILGEYMLKGWTLTDLHCDTCRVTPLMREPAAVAQREGRTSIQFCALCDGSPAGQSTTPLSPPSSSNQPSASVPAKHDPEPSSSYAATSEDPASQISSLLLKGYSLLGTNCPNSTCRGIPLVGFPRKADKTRDGRRMCVSCHGRWVEEGNMGGLKIIAPPRTKIEETRDDRSLLEASEESRSPREKRRRELYGLDVPSVGKQDSKGKNREDEDDFDVDMDIEGPIPPPKEAASKDLPSLATNASLNSALHAAQSSLALTLSRLAISLEQHHTSDEARYFVDVKLHTEAMRDVLDVLERMKRVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKV9</accession>
    <name>A0A1Y2BKV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_5828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2BKV9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="315" mass="34410" checksum="9BAA2C17A4E98309" modified="2017-08-30" version="1">MPATSPSSTSAPPSSIIGTSSAMDTPAPIARTSTETITTAPPTTATVPQAADTSSRSIYTLTPFIRPPSKLPTGEILLDWVVRVTINDGSGTGSDVRRDHPVCEWVNSQFLECKGPFYIRAEEAWKTSGISFSKTGERLTRVESKTGERLTWDQANSEWLTLDTETRRVLKKQKEEKGERLEGVNRDASYIESLKAQLQSYDGQEEEFTDDSSGTVRTYRIKWGSTIAPVTDRDKISVTTRRSTASRRSSLRSLSQKLSSMTLLSSSRPKSATGSNDREAPPEPNGDTATDGASELQDGASTWESAQCWGGMVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL57</accession>
    <name>A0A1Y2BL57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_555494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
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        <lineage>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BL57"/>
    <dbReference type="InParanoid" id="A0A1Y2BL57"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="180"/>
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    </feature>
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        <location>
            <begin position="358"/>
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    </feature>
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            <begin position="12"/>
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        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="40184" checksum="531C7A2F9DFFCE27" modified="2017-08-30" version="1">MVRNNKPYSRPETQRRANPDAGPWKHDLHESVKQSLASRISSSRGGSSSSSSRPSLLDRISGGQGKELFPSDSSGASKLHGFGSKPPINPTNPNAGLELFPAGGGRSTKREGPLKRVLEPGQRSLVSSGLDAALGRHQPRITPRSYAGQGVELLSPPLTGASSSSGFGLGRSTGNANGNGNGTSVGSVSIMGAAKGTVWIRVENLAQGTTADDVVSAFSPSPILTSRQTSPSDALTVTVELELASRTDADDLVKRYHGAVADGNTLSVTVIRVGLVERMQSAARVQAPPISAVVKKKEAYTGQELLTGRSSKLYSDTILASNPSAAIITLADQGASQRNRAAAWSRDTPQRESLASRMGFARGAGARNRGGGRGQIGGGSFASMMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLA5</accession>
    <name>A0A1Y2BLA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_8208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BLA5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLA5"/>
    <dbReference type="OrthoDB" id="2575338at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="97"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="334"/>
        </location>
    </feature>
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            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="825"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="965"/>
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        </location>
    </feature>
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            <begin position="186"/>
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        </location>
    </feature>
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            <begin position="288"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1158" mass="129838" checksum="54FE8BDABC3A0FC7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLB9</accession>
    <name>A0A1Y2BLB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_20738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLB9"/>
    <dbReference type="InParanoid" id="A0A1Y2BLB9"/>
    <dbReference type="OrthoDB" id="2574883at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="317" mass="35977" checksum="458603C0740A0A29" modified="2017-08-30" version="1">MKAASQRVTRSSPSPLLRQVSTSPPSLPHAPALPPVLPDTDTDTDTDTNTNTDAEVERGSPSSLNDGLAICLFGVSREMYDIEYEEEMRKQAVMNEVLPDAEMWRKWANSEAPLRRVRGWNPDLDRYFLQLLVESEILCLANPLNAPNPSGPPGQADRIHRHASRVRRVACDRIGIERLQAYCDRVREAFEAYMMTGWRGFIHDQNGKETGSDSDEEDNQDGRDEQVRDESEGEKKLIHEQEDDEDEDEDEERGRSIERGKGSVVRDNKEPRGGVVRDTMESEDLALDLDQEGMMRIELDDVHEVDEVSNDKTRVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLY5</accession>
    <name>A0A1Y2BLY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_475888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLY5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLY5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLY5"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="346" mass="36273" checksum="384157321BAF718C" modified="2017-08-30" version="1">MTTTNGTTNGSAAPHRLWANGPSVPLTTPFVAGGEEVDHEALAKQVVRIAKAGLGIVLLGTTGEASHMSHSERKAATATARKALDDAGLTDVPLCVGTGGGSLKTTIELCNDAAEAGASHCIVICPGYFSFAMGRDKTAILGFFKGVFDRSPLPVMIYNFPGAASGIDLNSDDISELAEHPNCFGVKLTCGAVGKGQRIATYTQTPEYLARRGNSLKASTVTGQFQVLPGFSESLLPTLLGRHTGCITGTGGIIPKTVRKLYDTAVKGLQGDSKALSEAVDLQEKVAAADWISIKTGVQGTKYALDTYIEKNLGGDWRSPLGPLTPAVKEMIDVDLKPFMEFEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLZ2</accession>
    <name>A0A1Y2BLZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_555928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLZ2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLZ2"/>
    <dbReference type="InParanoid" id="A0A1Y2BLZ2"/>
    <dbReference type="OrthoDB" id="3258237at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="308" mass="32485" checksum="521E84F50012C121" modified="2017-08-30" version="1">MATQTTTIDDTSPFIVYSSGGEWATDATLNTVMNASSATEAREPYYNHTYHNTPHDGDTATISFNGDGITAYGSMKQAHGYFQCILDGNYTLTQQGYSTVDVIPAEMCSFYDLTSGPHQLVLHNVPSLNASWQDPGFIGLTMAVDYLDISGIPIDADAYTASIAAETSGTATSESLASSTPSATTTSSSSPLPFSVPSPASHSSSTSTLPETLPVPPFSQIINPSTSNTSTSSRATLSSSQSTSSALTMTTSLQQSGISDLTTSGIPKIQQQSMPNLVLTSSSTPKSLESRALQVYMLLTIIMMYLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM21</accession>
    <name>A0A1Y2BM21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_512413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM21"/>
    <dbReference type="InParanoid" id="A0A1Y2BM21"/>
    <dbReference type="OrthoDB" id="2536450at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010995102" evidence="1">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="342" mass="35720" checksum="6EE4F302ABF1E69F" modified="2017-08-30" version="1">MRTATTTTAAFALGAASLAVAQNATSPISSIAQTAFGLLTPQCQSTVLQLTSNQALSQCLDFSGALQVISTNDSVLPPLDSWITDLCQVDPCSNETLTNVTSSLIAGCSSDLTNFGLSNDSISELVGFYPLAREVLCLKTVQPYSAPNATIPSNYTGYNSTNGTFCVTSELTKFSTYLGANFTVGYLTTLALGGNASALMSIDALPTISPTTFCSDCIFSAVDLIEQGYPKFGNIVLNSTANVTLDQYLDGSCSIYGYNTTTNGTLPLTIDEVAFNSTYAYNVTTANQTFTPPPYAVSETPLNGTAVTAVESAISTASEAVATTASVNATAMRARWMGQRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ACZ9</accession>
    <name>A0A1Y2ACZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_601503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000136">
        <property type="protein sequence ID" value="ORY20423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ACZ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2ACZ9"/>
    <dbReference type="InParanoid" id="A0A1Y2ACZ9"/>
    <dbReference type="OrthoDB" id="2552042at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="167" mass="17980" checksum="12DC79E7BCD1C087" modified="2017-08-30" version="1">MSVLRSSRYNPGSVYSAPPVGPHADAWDARPSMESLRDDGKPTGYQNEFSDVPGQHEYANPTGRYEDAYAEGSRAYPNEAGAYDQPQHGQYAFSTPGGGYVDHPPEAYSRDPGQTPTVNAYQAGQGWSAGGGGSNSGGLRMPEGTQRHPDCRSIRHTGHFHNPAEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF83</accession>
    <name>A0A1Y2AF83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_65853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000115">
        <property type="protein sequence ID" value="ORY21249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF83"/>
    <dbReference type="InParanoid" id="A0A1Y2AF83"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="118" mass="13981" checksum="42D67A298D76C15B" modified="2017-08-30" version="1">MVLTRVFFPKVMRVSRDKNAKSQFEDQRIKRPLGSFIKSVFGVHMLTTLTRRFGYKTKTHTQKNDLELWFWHSHAASFTLDRFFVVYVYVSASIVLTEQTKGKHKLWYAKLFSSRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGM2</accession>
    <name>A0A1Y2AGM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_567167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000105">
        <property type="protein sequence ID" value="ORY21743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGM2"/>
    <dbReference type="InParanoid" id="A0A1Y2AGM2"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000419">
        <property type="entry name" value="Monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="15"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY21743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="505" mass="55050" checksum="FA80D13FE5AB2B52" modified="2017-08-30" version="1">MPTIPLRGNKLLYAISATGGMGYCLFGIDNASLGGVISSDPFGARFHLNPTGQGAVTGAYEIGCFFGALLVSAFGERVPRRAVLLVSIIPLMIGAALQVSSFGVAQLAAGRVVAGLGMGGITSTLSVWQNETSPARLRGTLTCCSLSLLIVGQLIAYWAAYGLLLHYPTSDKTWRIMFSLQIIAGAILALMLTFMPESPRWLLSHGHEKEALGVLERLLDDTQKAQSQVREILAAIELEKASAKSWGDLFKRSHDGQGEKRRMATAIIIQVCQAFSGSTIISYYVTTIFQEAIGLSPHLSTLLSGYLQVFFLVCSFGTWWLIEYVGRRTLFLATALGMAIVLFLMGGMIKINTHGSGIAAAVLVFAYQALFTWGWMAGVWVYSSEINPLSWRTKGMGLAVAFQWLFVFTLLMVTPVGIANIGYGMFMIFGAFNLLFIPFVYFWCPETAGLPLESIDALFIPGVDPVKESARLRKELGRIRQETREEVTNQGDIDGKVLQEYVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJV5</accession>
    <name>A0A1Y2AJV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_370332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJV5"/>
    <dbReference type="InParanoid" id="A0A1Y2AJV5"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012621192" evidence="6">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="78"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="264" mass="28497" checksum="84B17005853B86DF" modified="2017-08-30" version="1">MLALLRYPTAFLALLSFTRAWNWKVSNGTDFHPCSGTVNPNQTADVTTDVYNQLQLARSSADRLTLLNDQNNTDLWKFNFNPTLESSFASRGAGGLAVLADRKSFPALIGTGVASALGFLEPCGLNAFHFHPRATQLVTVVQGGPLTAGALWSNAQTHQQFTTLVHTWEMIALPQGTIHYVFNDNCVPAITSNAFSSEDPGILNIAPSTFKFNADVLNGTLGYPSQLNGMSPSEFLESIPPSYVLGSQACLDRCGIDFTTAAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK14</accession>
    <name>A0A1Y2AK14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">BCR39DRAFT_551280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK14"/>
    <dbReference type="FunCoup" id="A0A1Y2AK14">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AK14"/>
    <dbReference type="InParanoid" id="A0A1Y2AK14"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY22567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="377" mass="41063" checksum="8237E0B701C709AF" modified="2017-08-30" version="1">MKRASVVLRTSRSSLSNSTRSRLSPASHPGSSSSGPFFGQQTIRSLSSSSKAYDAAPSSFTTINQSEISHFSRLSSQWWSPTGEFKLLHRMNPTRLEYIRQRVAFDERDEPEWTYAGRKQADTRGTGRWLQGKRCLDVGCGGGLLSESLARLGGDVVGVDASESNITIANLHASQDPFLPYKPVSSPLGSTTSSSSWFASTTTSAGSSSIPGSLEYRHTSAEALRDAGEKFDVVCAMEVLEHVDEPAEFMRCLGEMVKPGGHLIISTISRTPLARLLTLTMAEDVLRLVSPGTHTYSKFVKPSELRRFVYSDMGGFDTWEPELNAADVRKDEVGETKGIVYDPLGGVWRLWGGAVGTISRGLGEGCNYMFGARKRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKB1</accession>
    <name>A0A1Y2AKB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_550334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
        <property type="protein sequence ID" value="ORY22981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKB1"/>
    <dbReference type="InParanoid" id="A0A1Y2AKB1"/>
    <dbReference type="OrthoDB" id="2565303at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="335" mass="37977" checksum="C0DC0A0DD6DF7093" modified="2017-08-30" version="1">MGKWADSEYDRLAVAKLQRLFDIATASTDIEGSPGPRTLRTFIKELDPNDKAVQACFTKLVKRHFYSHSFPDTRIRVPVSPGSDPTFPTYPLGENWELFHEPARRRVDLAGDLAVSDVTIIDHRANFWRDQAAQSDQAATPVDPESPGRLERRSASPSHSPSRQALIDGAPSPSRSPRSPSRAWLDEYQASQSAAIRPSSSFRYLYPTRYRTRGREEEGQDEERERAVRLRHERDSPERRARRHRTNVVDLQRLMRTGSGRDTRRDGIVLDMPDDQPPWPTLNPEAEPFLPSQIIPNRSGLMAALMEDGTIDFVGNPAGTYEDSESDSFPPWRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKU7</accession>
    <name>A0A1Y2AKU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_487394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKU7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKU7"/>
    <dbReference type="InParanoid" id="A0A1Y2AKU7"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056300">
        <property type="entry name" value="SusG-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23915">
        <property type="entry name" value="SusG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="25"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="598" mass="69570" checksum="E0A46B418C01FA12" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKW1</accession>
    <name>A0A1Y2AKW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_549736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKW1"/>
    <dbReference type="FunCoup" id="A0A1Y2AKW1">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKW1"/>
    <dbReference type="InParanoid" id="A0A1Y2AKW1"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="264"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="427" mass="45566" checksum="0DBA32DEF1EF2715" modified="2017-08-30" version="1">MYYATAGQQATQPPGQSQARGMGFPPIGGIGRGGPPGFGRGSDSSDFPALGSHVPSSTYASQAQPAQGSSQPPHLAQQMLFSQGMAQGLAPPPPPGLGVPASASSNQTNGSGENLRGEDFPALGAGPDGKDRLAGYLRTPNQQPPPSPPVTLPNGAGGSHSNSATPSTNPPHPASGAGAPSTADSSWARHSPSRQQEPIVRPVQQIMSSPADQWGLKGLLYEIQMSLGKPDQQRWLFGDDLAEMGMDLSTDEPIYHNLVTPWVEPSQLSHPPQSDDPFHIPQCYYVNAQPIASKIQNFVDETLFYMFYTGIQDVSQLEAAEELYNRNWRYHTELQVWLTSPNIPSVENDPSTSWLTAPILVFDPSTFSRRQTPDDFMVELSLLEKTRSAATIISEEDARKGGAGEETNGLPGRQALASSFGQGIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL33</accession>
    <name>A0A1Y2AL33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BCR39DRAFT_591059</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL33"/>
    <dbReference type="FunCoup" id="A0A1Y2AL33">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AL33"/>
    <dbReference type="InParanoid" id="A0A1Y2AL33"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="252"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="473"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="541"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="806"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="1066"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="73"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="612"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="676"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="835"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ORY23212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1134" mass="126280" checksum="9D799EC03E607EF8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALK3</accession>
    <name>A0A1Y2ALK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_549321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALK3"/>
    <dbReference type="FunCoup" id="A0A1Y2ALK3">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALK3"/>
    <dbReference type="InParanoid" id="A0A1Y2ALK3"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="11">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="84"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="12">
        <location>
            <begin position="490"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY23443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="629" mass="70750" checksum="CED1D61D7A008600" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALN3</accession>
    <name>A0A1Y2ALN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_363937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALN3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALN3"/>
    <dbReference type="InParanoid" id="A0A1Y2ALN3"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY23127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="551" mass="60757" checksum="73141AF344B8A0BF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM31</accession>
    <name>A0A1Y2AM31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_549356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM31"/>
    <dbReference type="STRING" id="71784.A0A1Y2AM31"/>
    <dbReference type="InParanoid" id="A0A1Y2AM31"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY23350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="235" mass="25261" checksum="FE060474EED38DA6" modified="2017-08-30" version="1">MTTTHTTAKGMLFDMDGTLLDSTPAVNATWDYFAREYDLDLHEVLKTSHGTRTIDNLRKWCGLSEQAELEAATEQFESMIVSEAQRLKSEGKTGLEILPGVLDILGELDKASTPVWAIITSATLLYASDALPTAGVPKPPKLITANDVTKGKPHPEPYLTGAKILGYDIKDCIVIEDAPSGIRSGVASGARVLAVCTSHTRAKVTGLGATWIVEDLSKVKASLRDGLVHLDIDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM44</accession>
    <name>A0A1Y2AM44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_473005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM44"/>
    <dbReference type="STRING" id="71784.A0A1Y2AM44"/>
    <dbReference type="InParanoid" id="A0A1Y2AM44"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012101464" evidence="4">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="158"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="466" mass="49885" checksum="2617A1FDBD490CC9" modified="2017-08-30" version="1">MHISNLLLPAVLLGTTVSARVPVHGARRAAHPARAGNFEQIKREPVVETPTKKDKRLVRKKKRGSCQVHYNVTSSASSVAQTSTTAIGGGAWANPSASSSTESWVTASVSSSEAWATASASSSATWAASSSAAAHSTTASSAAASASASSSSSWYLTDTWSGNSFFDNWNFWSYDDPTHGTVQYVDSGTAWNDGLVSISDGHAIMKVDTTETVSSARKSVRIHGNKVWTGGLVLMDAYHMPTGCATWPAWWQNGPNWPYGGEIDILEGVNAFTENQVSLHTGSGCTMPSDINDNMIGQLTTGSFNSYDCASYDTSNQGCGVRDATSDSSYGTSFNSANGGVYAMMWAKNGITVWHFPRSSIPDDITNDAPNPDGWGTPMARFPSDDCSPYEFFYDHYNIFDTTLCGDWAGADSVWNYAGYAGQDQSCASITGYSTCSDYVLNSGSSFSDAYWEIGYVKYFNSTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMX4</accession>
    <name>A0A1Y2AMX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_548267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMX4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMX4"/>
    <dbReference type="InParanoid" id="A0A1Y2AMX4"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="513" mass="55828" checksum="8F19906AAB473FCB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANM6</accession>
    <name>A0A1Y2ANM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_547485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANM6"/>
    <dbReference type="InParanoid" id="A0A1Y2ANM6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="77" mass="8688" checksum="67E10B25BDDEED58" modified="2017-08-30" version="1">MYPVSSGWLKKGRDLQFAISSLQFAVCAAQSQDRHSRGRSHNIRSDATQQLTCLSSSFFSPSLVLWLLCIVQKEKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARG7</accession>
    <name>A0A1Y2ARG7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_544866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARG7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARG7"/>
    <dbReference type="InParanoid" id="A0A1Y2ARG7"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="42"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="363" mass="38740" checksum="CF9DE7D5B6845A51" modified="2017-08-30" version="1">MRFLPRISSPSVTRRIIVRTNMTSLNPKIPETMRAAVLRSPGGPEAFKIENVPVPVPKAGQCLIKVEAAGMNRSEMFTRQGHSPDVKLPRILGIEASGYVAACPDGSLPIGAKCITAMSGLGRAHDGGYAEYTVVDCKVVRLVGSGGESLPWDVLGAVPEMVQTAWGSLFIALKIQQGERLLVRGGTTSVGLTAIALAKNIGCYVAGTSRSEASRQLVLDSGADEFIVDTGSISSSRTEPSLKFDKVLELIGTVTLKDSLKLCRGGGSRDLPLGVVCMTGIAGNKWTMDDFYPMMDIESGVALTAYSGGEREMSLVPWEDIFHDVANGKLKIPVGKTYKLEDVVEAHRVMEDSKAGGKIVLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASJ4</accession>
    <name>A0A1Y2ASJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_544946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASJ4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASJ4"/>
    <dbReference type="InParanoid" id="A0A1Y2ASJ4"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="84" mass="9210" checksum="A8F251B6F2DED828" modified="2017-08-30" version="1">MSGFSIQRAALEGQPGLVRSLLSENPNLINAKDDDGRTALHWASTRDNLGMIQLLLGYQPDLEAKDKMGWTSLMIACESITFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASX1</accession>
    <name>A0A1Y2ASX1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_543682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASX1"/>
    <dbReference type="FunCoup" id="A0A1Y2ASX1">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASX1"/>
    <dbReference type="InParanoid" id="A0A1Y2ASX1"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="47"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="207"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="356" mass="39094" checksum="1A3ECE134F8B60B9" modified="2017-08-30" version="1">MRFPPITIARLRAQPLLVQKTSMSVMSVRMKSSVPLLITPEEYKKLPKATTVPLDVSWHMPNSPRSALAEYLSGPRLPHARRWNLDEVAELDVDKNPLSLTHMLPSKEKFREACEKHGISDDSHVVCYDTVGVFSSPRAVYTFKALGHDKVSALDGGLPRWIAEGGETEIGESADFGEGEYKGKEPLDGVVRSYEQVVSNSEKPLDDGNAEIVLDLRSRARYDGTAPEPRPGLSSGHIPNSLPAPFSDYLEPPSDTKPYSHYKSLPELKTVLVDAVGGEERWHEIEQGHRGVVFSCGSGMTAAIGWLAEELIKDAEGWKGPSAIYDESWTGYASRQESKIVKGDKVVKGGVNPNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT26</accession>
    <name>A0A1Y2AT26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV radiation resistance protein and autophagy-related subunit 14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_590016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT26"/>
    <dbReference type="STRING" id="71784.A0A1Y2AT26"/>
    <dbReference type="InParanoid" id="A0A1Y2AT26"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="803"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="920" mass="100165" checksum="E5100AD11DFD3D49" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUJ4</accession>
    <name>A0A1Y2AUJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUJ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AUJ4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="331" mass="36148" checksum="1AA3B69DDBCDD78B" modified="2017-08-30" version="1">MYHRDGLEEGEARASRSGLSLLLEALALPEKARPEYSLYTQSYLNPSSIEGKSLDRKLFLERTANWLEHGVYARLEVPTRLMSSSKKRKESFYQSLEMCSWLLSEAQVPYTLLSDTDLKAEYQRFREETTIFVVATEEMYGDEQSTKTLDQYWTKSVPWPGDRPEDSSCRAFCRIHPSVFDRGREPQASSQGGEPKANNQGEQGPVVSEIPSDSERPTGIHSSSDGLGDVQVTELSPNAETDPSQQVGDDDRVGKDDGPTAGSQGGHSEGRVSVPGGEIESAGVSPSEVEVFAGDGDASIEWSLDLNGTALALNVETITGPSRGEVSVVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUJ5</accession>
    <name>A0A1Y2AUJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_541795</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUJ5"/>
    <dbReference type="FunCoup" id="A0A1Y2AUJ5">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUJ5"/>
    <dbReference type="InParanoid" id="A0A1Y2AUJ5"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY26273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="56" mass="6283" checksum="4B6367921DD847A1" modified="2017-08-30" version="1">MAIAPVVGKLRKRLLTDLSIAFGIGTAGAYAFWYGYHLPSIKKRDDFYIKYEASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUX0</accession>
    <name>A0A1Y2AUX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="10" type="ORF">BCR39DRAFT_589762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUX0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUX0"/>
    <dbReference type="InParanoid" id="A0A1Y2AUX0"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="999" mass="106443" checksum="83D65F658E594795" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUY1</accession>
    <name>A0A1Y2AUY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_542224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUY1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUY1"/>
    <dbReference type="InParanoid" id="A0A1Y2AUY1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF7">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="448" mass="49413" checksum="98B1F473C724B799" modified="2017-08-30" version="1">MQRISYLIQLMLTPHMALSTTLLSMAPLNVLIVGGGIAGNALAFWLSKLNHKVTVVERFPTLRDTGLQIDLRGHGVQVMKRMGLEDKYRGKLAPEQGVRVVGSSGRQWAFFPAKTSSSGIQSFSTEWEIMRGDLTKLLAEACDGRVEYLFGSSVKDYSEHDKGVHVTFENGTTGDFDFLVGADGVGSRTRRTILEPGQPDPLHPLDNLHVAYFTLPRPIQKDEKYVATVYMGTNGRGIMTRRQNPDSLQVYVGGRTDSGPLTTVKRGDVPAEKKALGDFMRGGGWITDEIVEAFDQADDFYLERLSVVKMDKWSKGRVVLLGDAAYCPSATTGMGTTSSIVGAYVLAGEIAKQKPQPNDINALTRAFTEYENKFRPFMDDVTKGILESGGGFSMPTSRIGITMMNLMAGLVSFLKIDVTRWMVKEHVSGWDLPEYEELSDIVKSCRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVF9</accession>
    <name>A0A1Y2AVF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho GTPase activation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_540643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVF9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVF9"/>
    <dbReference type="InParanoid" id="A0A1Y2AVF9"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000045">
        <property type="entry name" value="RhoGAP domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="4">
        <location>
            <begin position="459"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="654"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="92998" checksum="0235AD7783D99E4F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVI7</accession>
    <name>A0A1Y2AVI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_542604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVI7"/>
    <dbReference type="InParanoid" id="A0A1Y2AVI7"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="449"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="911" mass="103801" checksum="3FCA59C1914EB0B6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVU3</accession>
    <name>A0A1Y2AVU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_470169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVU3"/>
    <dbReference type="FunCoup" id="A0A1Y2AVU3">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVU3"/>
    <dbReference type="InParanoid" id="A0A1Y2AVU3"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="220"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="434" mass="45928" checksum="B0FF18C2C97432EE" modified="2017-08-30" version="1">MPPILLSCGSNGSSQLSLSHAQDVHTLTPCHFHPTISSLLNKPYSITDLVSSSTHSLAIVHSSELDSTILLGAGTNTLGQLGPRCALWDDVKPESRFKPVDLLTPLGLSADDWAPCKIATTWTTSFVVYRRRIANLIGPTSGSGSGSVSEEQMMIACGSNDFGELSIPSINAEEGKISITRPSDVPTIVKLGLEKGEWVEKVKGGQKHVLVLVEGGPDGQRLIGWGASRRGELDPTSTSSSKPKGKGKAIPYPSSSPPTPVRLDIPPGERIVDIALGANHSVALLSNGQVIAWGSDTKSQISSLGQVKGIKSIATTWGGTYLLTETGEIWSQGSNTHSQLLRSGEGPASRGTVQLPSGVVVGTLCTGSEHVMVINQERTQMWVGGWNEHGNLGVGDCADRHRLVAVDLVNKGRKIREVWGGCAATWVCLEDDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWI1</accession>
    <name>A0A1Y2AWI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAP42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_484097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWI1"/>
    <dbReference type="FunCoup" id="A0A1Y2AWI1">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWI1"/>
    <dbReference type="InParanoid" id="A0A1Y2AWI1"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="401" mass="43875" checksum="F5B8838639AF396A" modified="2017-08-30" version="1">MSSTDLPIPQFYAQTLQSLVPIFDDTLSTSDSSAQTLLASALDNLHLIARMLTSLGVFSDNETADELGDKELVFMSLGWVIAECESRGGLGGPERRKAALERSQHAMNGFLSLLASYKVLSPEEYAESSASADSGVIAKDPAKRREAKIRQYRREKELRQQISTMANDHPDSSSTPLIFILSLLPSTSASRPAVISTSTASTSVNPDSHPDIRETSLLLLRLLHTLALASLSSTAMELDILASAPASISELPPPPEDLRSVKRGDEDNTWRLDRTPGQYKPRELISGGGRVLRPFTILPSTSSLSDRARLQGEVFRSSHRLPTMTIDEYLEEERRRGNIITGGGQASYDAPTESELLELAAEEDGNAGAEEAEEKKRIKEENWARYTDDNRKGAGNTMNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWQ6</accession>
    <name>A0A1Y2AWQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_246411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWQ6"/>
    <dbReference type="OrthoDB" id="2607257at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="117" mass="13248" checksum="C36D276337961CDC" modified="2017-08-30" version="1">MEPAVDSLARKQRKRRKLLSCSECRRLKLKCNREVPCSHCVRRKCVSMCSGQNEAEQQEGSRASLSSRVNLEESELITSQSHDKSGHSCSPHVYPFGTLRLIYLTSSRANRSLSYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX64</accession>
    <name>A0A1Y2AX64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_578119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX64"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX64"/>
    <dbReference type="InParanoid" id="A0A1Y2AX64"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="302"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="668" mass="72776" checksum="96583946C1B2F7C5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX82</accession>
    <name>A0A1Y2AX82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_538612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX82"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX82"/>
    <dbReference type="InParanoid" id="A0A1Y2AX82"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF330">
        <property type="entry name" value="SNF1-ACTIVATING KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="159"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="614"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="729"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="902"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="985"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1062" mass="115045" checksum="40CAC862DF2E943C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX85</accession>
    <name>A0A1Y2AX85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_448156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX85"/>
    <dbReference type="InParanoid" id="A0A1Y2AX85"/>
    <dbReference type="OrthoDB" id="2589819at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025494">
        <property type="entry name" value="DUF4385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14328">
        <property type="entry name" value="DUF4385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="128" mass="14973" checksum="0BEB984279E5C7DB" modified="2017-08-30" version="1" fragment="single">YKALKTEQGVFTTPPYSAAIKPLWRFADEAAAIKSSEAIWERFIEYRNQSDFIGMDISRKFIQMGRTRSLRYALRRSGRKYDPSSGKEMERTGEVYDVEKSKGARVFETVLERCWSDIIYSEAFEAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXU9</accession>
    <name>A0A1Y2AXU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_538312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXU9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXU9"/>
    <dbReference type="InParanoid" id="A0A1Y2AXU9"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="102"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="716" mass="80960" checksum="75595FB7711C1755" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXY2</accession>
    <name>A0A1Y2AXY2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SCO1/SenC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_497217</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXY2"/>
    <dbReference type="FunCoup" id="A0A1Y2AXY2">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXY2"/>
    <dbReference type="InParanoid" id="A0A1Y2AXY2"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="130"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY27453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="270" mass="29833" checksum="A20C79C0C20FC855" modified="2017-08-30" version="1">MNTLRSALTRTVGSSSRQALAQPARRAAAQVPRRGYAVKREQVFRDKANVGPVSWTSAVIFIATGFGLYFYFESEKAKVQKRKQDEMAAKSIGRPNIGGPFQLVNSDGSPYTEQNLRGHWTLIYFGFTNCPDICPEELDKMGEAVDKVGSDEVLPLFVSVDPARDSPEQVKKYIKDFHPRLVGLTGDYDAIKRACKSYRVYFSTPPNAKPTDDYLVDHSIFFYLMDPLGQFVDAFGKATTADEVADKVRTAMGKWEAAGGNVAAGLPVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY43</accession>
    <name>A0A1Y2AY43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_539021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY43"/>
    <dbReference type="FunCoup" id="A0A1Y2AY43">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AY43"/>
    <dbReference type="InParanoid" id="A0A1Y2AY43"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="379" mass="39734" checksum="036DD5CFB6310653" modified="2017-08-30" version="1">MAHTPPKNIIIIGAGIAGCSTAHYLSISPYLPSGTRITLVEGTKVAAAASGYSGGFLAKDWHGTATASLSTLSYDLHSQLAKEYGGADKWGYRTVDTLSVEYDATRPSKNKSPVSWLPDSMIHASRQLGDQTTNAQVHPGLFTTFLSEQFLSKPNTSLVLGRATKLDLDGQGKPTSVTVQLQQGGEKQLDADAVVIAAGPWTGKLSVDLLGHRVGGRLGVQGHRAHSIVLKTKEALSAHCLFTSMSMEDGTQGEPEVYTRPDGTTYICGAGDDAPLPDTAADVIVSPVLIARLLKQATELSPVFQTSSGAQVIAEQACYLPIADRGRPLVGKVRDVEGVYVGGGLSCWGITQGPGTGLVLSELILEGKAKSADISKLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZA7</accession>
    <name>A0A1Y2AZA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_559890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZA7"/>
    <dbReference type="InParanoid" id="A0A1Y2AZA7"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="222" mass="24247" checksum="C2A54A933F4378BB" modified="2017-08-30" version="1">MPTDGKASTVTTLEQRAEAEVKAATNAADGKVQDLVDSNADTTDSNMRYAAYLRRARDIVRAGSRYTAYTSDVGEAFRPVVPPYLVTAAYAISWSYLIGDVSWATYKSSQLGPSPIEAANISEPTRLALVAVKRSVFQGIASMALPAFTIHTAVKYAGRQFAKSTNTTLKRWGPTSVGLGIVPFLPYLFDEPVEHVVEATFDKLEENWFRKTTEPSAAKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZD1</accession>
    <name>A0A1Y2AZD1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_217269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZD1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZD1"/>
    <dbReference type="InParanoid" id="A0A1Y2AZD1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="40"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="2">
        <location>
            <begin position="195"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="419" mass="46291" checksum="412AA92E5ACE417B" modified="2017-08-30" version="1">MRPSQLRNLGITRLLRATEGMGSNGPVPKANLLPVTGPQVKVLIIGAGNINFGSEEGPWNHSQRLERKLGTRLKVIGLVDPAVARAQAVLEAKSLTFAAPAYSSTEIYASVQAAVSGLSSEPPDVIILGSPPAFRGTTDASKGFDTEVQLSSGFPSSALFVEKPVSTGLVEEVRLVADLLETRKGNLVSVGYMLRYSAAVRKMKEIIKENELNVMMTSARYIMAYEASRKLAWWDKRIDGGPIVEQATHFCDLSRYFGGEVDLDSVMAHSLEWYEKPGHLSKIQVNELQIPEDERIPRFTSATWKYESGALGHLEHGVSLQGSDFNTELAVYADGYLLKLVDPYNRPTLYVRRPGSDSEEVHAFHDDDPFLSEMSSFIDMATTGKAEVPILSSYADAVRTYEMTWAIRWASEKTRRLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZS0</accession>
    <name>A0A1Y2AZS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_536874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZS0"/>
    <dbReference type="InParanoid" id="A0A1Y2AZS0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="303" mass="33058" checksum="478787CF5A84DEA2" modified="2017-08-30" version="1">MSGIRPRQSAADRQSAPSTSTRQQGAPSTSTESGPSRAPMSVLWQPTSTGMPDLSRADTAQAISSSIRPSRQGSEGATPLTTTKWRTWPDRGSSPMSSPQISTYRRTPPPSSTGRHTDTTGIGSLRTNPTRYRQGNTRSTRERTGRSAGTIPTGGTLGFDPYTLPLPDIASRSRFPTTHNWRGEHTDVWKRRCRLSQQLLWQFRRVCTQAGFLIPLGTSPALLNASRAFDGIVLSRPSEDGNSQISQRLPTGTLLAPALMTTLYASESVINKNQRYLDHAQSNGTPVSLYTRQDDYGSYCAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B028</accession>
    <name>A0A1Y2B028_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_535970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B028"/>
    <dbReference type="STRING" id="71784.A0A1Y2B028"/>
    <dbReference type="InParanoid" id="A0A1Y2B028"/>
    <dbReference type="OrthoDB" id="3046788at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="677" mass="76544" checksum="297901130CE8B0C2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0H9</accession>
    <name>A0A1Y2B0H9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_535506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0H9"/>
    <dbReference type="InParanoid" id="A0A1Y2B0H9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="252" mass="28253" checksum="38CE1689F88B52C7" modified="2017-08-30" version="1">MTSSDPDTRLPGSGPSLYPLYSYPTVRMLDSTEYPFTAFLSPCHPKLKTGTGAGESQDTVGYEDSHAESDVNAGSGWTITIEEYWRNTPTVKADSKLKQMGEAVTRAWERATRYDEKPAKIVVGTDPRTKQILTKTSVQERTTFASRTWSRKYGVLTYDVMSQLFKQKNTAMVDLVGHYLEWEIRNKVLNEFIAAEMINQEYSYAEALKSEQESLFTALVSMAESSHVDTSRDDEDTLSFHPSISVPGNSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B111</accession>
    <name>A0A1Y2B111_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_535893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B111"/>
    <dbReference type="STRING" id="71784.A0A1Y2B111"/>
    <dbReference type="InParanoid" id="A0A1Y2B111"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="434"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="577" mass="64057" checksum="5698D159BDEC0350" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B161</accession>
    <name>A0A1Y2B161_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_198003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B161"/>
    <dbReference type="STRING" id="71784.A0A1Y2B161"/>
    <dbReference type="InParanoid" id="A0A1Y2B161"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="101" mass="11036" checksum="FC18324569F0C169" modified="2017-08-30" version="1">MPAKKRCQFKVIYNIPTTPTSATTDGEVSKPEMTANPTQCPSAALRVAGDCPHCQRVFCSTHRTPESHNCTGIQACRDAAFQANKERLEKERTVASKIAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1Y4</accession>
    <name>A0A1Y2B1Y4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_505773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1Y4"/>
    <dbReference type="InParanoid" id="A0A1Y2B1Y4"/>
    <dbReference type="OrthoDB" id="2571549at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="136" mass="14599" checksum="8044CCEE747207FB" modified="2017-08-30" version="1">MSKPSYAAVVAAPGKPSGSDVTPAQNNGEAPPPFADTPGPSSAPHQTLLPPQHHPETQAQLGWTPPASMQVARARALRRFWVAFFWAWAIWILIGLIIGGGVNDVNSEPVGRHGHWDRNGDWHDDRQGVSIGGGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3E8</accession>
    <name>A0A1Y2B3E8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BCR39DRAFT_532450</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3E8"/>
    <dbReference type="FunCoup" id="A0A1Y2B3E8">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3E8"/>
    <dbReference type="InParanoid" id="A0A1Y2B3E8"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="199"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="735"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="22">
        <location>
            <begin position="1000"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ORY29351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1153" mass="126401" checksum="13464342B03ED051" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3F6</accession>
    <name>A0A1Y2B3F6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_175406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3F6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3F6"/>
    <dbReference type="InParanoid" id="A0A1Y2B3F6"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1145"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1145"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1191"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY29363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1255" mass="138135" checksum="62EA0A36157173C0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3W6</accession>
    <name>A0A1Y2B3W6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3W6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3W6"/>
    <dbReference type="InParanoid" id="A0A1Y2B3W6"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="535" mass="58985" checksum="A4A1F38D66A232A3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4M4</accession>
    <name>A0A1Y2B4M4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_588545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4M4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4M4"/>
    <dbReference type="InParanoid" id="A0A1Y2B4M4"/>
    <dbReference type="OrthoDB" id="2587207at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="190" mass="21076" checksum="1E435CFE22230AEC" modified="2017-08-30" version="1">MIAARNIFPLPSSTPAEVPYQNLIDSSQYARNNFEPTKRKFAKTLSADENEAVLRLRLKQYWGHSEFRYPQLEICSSAMKDHDILVVAPTGLGKSVCFQVPAIVKAYGITLVVSPLLALMKDQVRSLQDKNLCAEMLCHETEESKRKERLANGPSKYSASLRHPRDAIQQASSSRSPGRLFATTVVPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4P2</accession>
    <name>A0A1Y2B4P2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_531048</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4P2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4P2"/>
    <dbReference type="InParanoid" id="A0A1Y2B4P2"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011827905" description="Endoglucanase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="12">
        <location>
            <begin position="46"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY29793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="589" mass="63211" checksum="E3F1236CE2CFDE6F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4Q6</accession>
    <name>A0A1Y2B4Q6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_531147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4Q6"/>
    <dbReference type="FunCoup" id="A0A1Y2B4Q6">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4Q6"/>
    <dbReference type="InParanoid" id="A0A1Y2B4Q6"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="615"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="755" mass="82757" checksum="E187A20021DF7041" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4R5</accession>
    <name>A0A1Y2B4R5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_558950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4R5"/>
    <dbReference type="InParanoid" id="A0A1Y2B4R5"/>
    <dbReference type="OrthoDB" id="1743579at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="63"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="345" mass="36521" checksum="31AE6F10D43A3577" modified="2017-08-30" version="1">MSHTIPSSQQVLVESTIEQFAAGSTVQAQIATAHNTSVSGTYSLYFEYCEPKTATPAGIFQTHHGLVGNAAYWNVQLDNKTDNSFAESAAAAGWSTLSYDRLGVGNSSHPNGLTTVQINYEIAQSIGIAQALRNGYLSDLGKWSKVVGVGHSYGSNLLTGVAAINPGVFDALVLTGFTNNATQGPLGLAGFSSTIASVAYPSRFSSLGNDYVITPSVSADQLGFFHYPNYTQSALELFTTTKSEYSLGQQNSIAGPLKLNRSNYTNPTLVVTGANDAPYCAADCSVTSLGGNKTQLDTARTLYPGVADSAFETFVVPATGHGINYHETAYAAYQEIIAFIKRQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4Y7</accession>
    <name>A0A1Y2B4Y7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">57.7 kDa trp-asp repeats-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_531220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4Y7"/>
    <dbReference type="FunCoup" id="A0A1Y2B4Y7">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4Y7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4Y7"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000926">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="8">
        <location>
            <begin position="372"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="523" mass="57796" checksum="8710A94F43ED810F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5L8</accession>
    <name>A0A1Y2B5L8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_530698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5L8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5L8"/>
    <dbReference type="InParanoid" id="A0A1Y2B5L8"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF129">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE C1773.17C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="77"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="133"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY30024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="349" mass="37453" checksum="1344A94AAC218BD3" modified="2017-08-30" version="1">MPVAVATTTSRPRVLLLGESSGDDKADKSIRAIADTYTVPRGNLEEVAGYIASAVKEHGPFIAFGATWALGEKFPARFDESLLSPLFPGCKLLVTPGAGYEKTDVNYLTLNGCVYANSPFAVGQRTADGALLLTLAAMRGLTPQDNSMRIGNFADPSVRTLSHRSANIAIIGMGNIGLQLAQSLTAIGAPTQNIRYYNRRERVGCGYEWASSLDEIWKWAQVIVLTCPLTEHTRHLISRDALEKMRDSVIIVNVGRGPCIDEQALVDALDSGKVMRAALDVFENEPQAHPKLLTNPNVTLSPHYAANPDGMAPGMNAEVLENIIQFIQTGKPQTPVNLAEVAAAATPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5V2</accession>
    <name>A0A1Y2B5V2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuole protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_466825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5V2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5V2"/>
    <dbReference type="InParanoid" id="A0A1Y2B5V2"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41468" checksum="147C6AEC143BEE51" modified="2017-08-30" version="1">MCCEAEWKREVVQDHKFDFINVSEFHRTDILTRLKYVWKYILILKAFAVMGLDIFTAVTMISSNHWTNTIQSRCGDDCAVDVKFAIAKWVFVGCIIFSFLLYGYELWKAKWVIDSRDISYAFTNLLANDYCSLKSYDNFCLFCYIDRSTKKKDDFAFFVFFTFKDWKRLLLADGPRQSINALILYSFANSFGWQTSDIPAYWDNSPITAMLLFSMILTVLIFAGSLILLIIAAVCYVPLLCYIQGNLKASSEYVCHKVDKRIAELLRKKQRQRVARNLALEKQLAKSGMKTMNGEMVLPTLPDVKLDDDALSISGASKPRSKKMEYDNYNMNVAGLGYPPVVEYQTPYGGAGMLYMEDHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B626</accession>
    <name>A0A1Y2B626_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_153047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B626"/>
    <dbReference type="STRING" id="71784.A0A1Y2B626"/>
    <dbReference type="InParanoid" id="A0A1Y2B626"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="23423" checksum="FD951DF60132D714" modified="2017-08-30" version="1">MPHYFIIGATGQCGLAFAHAALAAGHTLTLYVRTPSKLDPSLNEHESVKVKVGTLTDEAKLREALSGDTHIDGVISFAGPAAGNKGTPLTDGYKVLVPLLETLGIKRFLILSTPSYIVPEDQLTLKWRAVIGLVKIIGGTAYEDITSFSKDIESSSLDYTLFRVPNLTNGEAGPVEATYVGTGRDGLFLSRKSMVKWCLEEFESGKWIRKAPKIANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6D2</accession>
    <name>A0A1Y2B6D2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP citrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Citrate cleavage enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">BCR39DRAFT_529649</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6D2"/>
    <dbReference type="FunCoup" id="A0A1Y2B6D2">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6D2"/>
    <dbReference type="InParanoid" id="A0A1Y2B6D2"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="28">
        <location>
            <begin position="2"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="27">
        <location>
            <begin position="282"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="26">
        <location>
            <begin position="528"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="25">
        <location>
            <begin position="694"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="ORY30391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1139" mass="123556" checksum="CF2D1B2EB89F5752" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9S8</accession>
    <name>A0A1Y2B9S8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_558515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9S8"/>
    <dbReference type="InParanoid" id="A0A1Y2B9S8"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="500" mass="56366" checksum="E86C0CDAF9AD717B" modified="2017-08-30" version="1">MGFFHELRLFFIGEKPATKAESRLLRKIDTTILTFVCLSQFVNYLDRQNLANAYVSGMKEELGFQGTQYNQAVSIFTAGYIIGGIPNALIVSSNRIRLSIWFPFCCMMWGMLTLGLGFTKHVYQVEVIRFFQAIFESSTFAGSHYILGAWYKPSELGKRACLITAASNGGILFSGVLQGGIQSTLDGKCGLSGWRWLMIIDSLITAPIWILGFLTFPEQVTPANTRAFYITEEERRQAVDRLPPHKPTKLDWNVFMKVGRDWRFYAFTIMFSLNTNMEFAGLYSIMSLYLKWAKTYTVQQINYYPLGTTAVTIAGTAFFALWTDYTKSRWWVNIVMALCAGLSSILLLVWDIPLGLKYFAYYFAGLGYIGQAVNFAWANEVCRDDDQLRALTLYSMVYGSNVTIAWFNIALFPVTDAPRFRNGMIAVIVTCVISPPMAIVLRHYDLKRRTKLAGLVHVLPEDQVASTVPAIEEKQDDKGLGQGDVQDTQQQIKVTTVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAU9</accession>
    <name>A0A1Y2BAU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_526125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAU9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAU9"/>
    <dbReference type="InParanoid" id="A0A1Y2BAU9"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000137">
        <property type="entry name" value="DNA polymerase epsilon p12 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="307" mass="33572" checksum="E8C162A085C17858" modified="2017-08-30" version="1">MQVDYAPATIAGASTGMPPPPDMAEISEPEEEEEETVQEDAAAEANAEVKEKKKRIMKQRQSLAEKQPGTTIFPISRIKRIIRADKELDMMTSEATFMVSVAAEYFIKHFMEEGYTKARLEKRRIVNYKDMAAVVARSQDFDFLKDVVPAPIPISEALQLRKQKMALDENPTLHDDIVPSDPRDLADQLPPLTISTNPLFPNAIVKKPPNTHSKGPAAAAKAAAVKEKEKAKDAPADRVEASKGPSTPRLVTGKNAPSTPHSLTTRGSARRSIVPAEAESMELDSTAQNGASEVAVSVEEDDRMDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBA4</accession>
    <name>A0A1Y2BBA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBA4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBA4"/>
    <dbReference type="InParanoid" id="A0A1Y2BBA4"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16521" checksum="933053F0815D11FC" modified="2017-08-30" version="1">MSREAESGTVTPKRRKAHYSTPPATIRKSSGSDSTGLLLTRMLNSQTTSVLNELDTSEAADEGYFTSWRGRRIRKAGVGGWACDEAELERQDSEHWLLRLLLGHPFVGPVREVLHAVQGRPRILDITTGTGAWAIEMADMFPLSGILSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBB1</accession>
    <name>A0A1Y2BBB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBB1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBB1"/>
    <dbReference type="InParanoid" id="A0A1Y2BBB1"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="583" mass="66578" checksum="B4A3CE3D0EAFB9FE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBI4</accession>
    <name>A0A1Y2BBI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBI4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBI4"/>
    <dbReference type="InParanoid" id="A0A1Y2BBI4"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="176" mass="19409" checksum="92986F61C84EBB5E" modified="2017-08-30" version="1">MASLVPQTPSLPSGKPPLPWSVNAVDAASHGSIAFCQIYYETYDEPSRRVRDIPLLYLPQATIIWNGNRISSDRDKLSQFLEAMPLSRHDPQTLDCHPVAALDPTSGPAPDLIINITGSVLHGPSVAAAYDSRGPNVSPQDMPRKYHEVFILRAAEQEEDMQPKYAIHSSTFRFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBM9</accession>
    <name>A0A1Y2BBM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_59383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBM9"/>
    <dbReference type="InParanoid" id="A0A1Y2BBM9"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="59689" checksum="DF770DB904B21DE4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCD0</accession>
    <name>A0A1Y2BCD0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_524513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCD0"/>
    <dbReference type="FunCoup" id="A0A1Y2BCD0">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCD0"/>
    <dbReference type="InParanoid" id="A0A1Y2BCD0"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="140" mass="15317" checksum="2DE100D96D89EEFB" modified="2017-08-30" version="1">MTSLASCLFCKIVKGEIPSMKLLETDTIYAFMDIGPIAKGHCLVIPKYHAAKLSDLPDDQMNDILPACKQLAKATGAEDYNILQNNGRAAHQIVDHVHFHVIPKPAGAGDKAGLVVGWPTQTELSKEDITKSFEEMKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCI0</accession>
    <name>A0A1Y2BCI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase ligase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_479404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCI0"/>
    <dbReference type="InParanoid" id="A0A1Y2BCI0"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="313" mass="35539" checksum="130E4770E1B41742" modified="2017-08-30" version="1">MWVLHQLSETRRHKTRTGAVPSIDPQSQPSSAEKAKAPRAQVGSAWGFSPEEINRFPALRRRNFWCIQRHQARALHYDLRMQLDGSTVSWAIPKGLLGISKRKEAHRLAVETTLHPNSYTTHEGSDGRTLPSGLRGGTLLWDVGYYLITPKPQEDDGMETDNEDMTRKRRRMQYGDDESDGLGADHESAFRRAFHKHPRAGGVKSIHFTLTGGRKMTDHTFILILPSSNSRSIGYESSGRVKKTWFISLPRGVEEYSWGPEGEEGAQYGRSVKTGRTLREVCNSTPYIWQPWPNEPVEWADARREIDATDRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCM4</accession>
    <name>A0A1Y2BCM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_378931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCM4"/>
    <dbReference type="InParanoid" id="A0A1Y2BCM4"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="168" mass="18153" checksum="950019A00135EE45" modified="2017-08-30" version="1">MAPKVREPFHPLLKASEIEDSMDTFPHFLDAKAIKSHSYMSDILGLKGLGVVKVNLPAGNNSCTPHYHLNTAEWLYILKGTGHLILIDASTDCPPFKPDSSKPLPTTAHVPKVELPTEEREVGPGDFIGLPGGTVSARWTHTLRAGQGGLEYLMGGERAVVDVVGYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDG0</accession>
    <name>A0A1Y2BDG0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G protein signaling domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_522977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDG0"/>
    <dbReference type="FunCoup" id="A0A1Y2BDG0">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDG0"/>
    <dbReference type="InParanoid" id="A0A1Y2BDG0"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="393"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="623" mass="69122" checksum="54A462E04D27F953" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDG5</accession>
    <name>A0A1Y2BDG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_522253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDG5"/>
    <dbReference type="InParanoid" id="A0A1Y2BDG5"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY32879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="310" mass="34293" checksum="409CE347E0220C16" modified="2017-08-30" version="1">MATSGAVRAVRIAVSGTSVIQQSARFRSTDGLVGCSCWVQLIPVKQFSTSFRAHRQGHSKQETDRVDGGDVVSASDKEKVGLLEDEAKYDDEEELDGIEVDQVPDEALPATLTNLKRPRLPTSMKKLNRILGSHRSVPLPDSDLLETFVRGRGPGGQAINKTNSSVSLIHLPTGIRVQAQPTRSREENRKAARKILSERLDHLRSNGLLPVYDSESVTQGQVKVDTENKENDNDKKGMGKKKQFKEEAKELAGLYTKKEVRGMKIQARKADKAKKHKRKLKKKGEEEEAMAVKDNRDVAHGGDKEQHGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDT3</accession>
    <name>A0A1Y2BDT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_557432</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDT3"/>
    <dbReference type="FunCoup" id="A0A1Y2BDT3">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDT3"/>
    <dbReference type="InParanoid" id="A0A1Y2BDT3"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="178"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY32876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="432" mass="44415" checksum="3A5148A74C364141" modified="2017-08-30" version="1">MLLSRLQRASRSALRTYATVAEASGVKVAGFEGGSPPATTSITVVVKGGARYESKPGVAHVLKNFAFKSTAGGSALKTARETELYGGVLSSALSREHLYLTAQFLRGDEAHFLELLASVLSSTHYYPHEYAELVLPSIESETLASLASPSTLALDLAHSIAFRRGLGNSLYASPHSPVSAADVKAYAQQAYAKSNIAVLGGGISTDNLAKAVQSAFGGSSSGGSSLSGSTSTYYGGEQRVPLDVHATPGAQPTLIIAFGSAGEAKPELKVLPHLLGGQSSIKWTPGTSPLALIADKVPGSSIKATLYPYSDASLLAVQISAPTSEAVGTLAKEAVQAIKAAGSAKAEEVKKAIAQAKFAEATKFEYSDLFLQTAGPALFSGSIPAPDSSFASLDKVTASALTKSATELFKAKPTVVAVGDLGVLPYADELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDV2</accession>
    <name>A0A1Y2BDV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_520775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDV2"/>
    <dbReference type="InParanoid" id="A0A1Y2BDV2"/>
    <dbReference type="OrthoDB" id="5541797at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="301" mass="33313" checksum="CACF465F8A9D90F5" modified="2017-08-30" version="1">MQNQVSRAASGSKSWTSTRPIKPRRRFGFAYLARLQRASYPKNILIDGVPHTSLPNDVLRALKESRIVSHDFPITSISPPPISLPRTPSLTRTYHLSFGSSTEAISAFEKLKGLTPPLFPLHAFESTLHTAPPSVEFTLDDPSEWRVFCMRDHERHLQDTIQRRGGGGVGGGDRNRGGEAGGIGGGGGGVGRSGNSIIDNEEFDLDWMEKNQPSRGRRVLVKGLPRLLPSSVAAALSKDFEMEQEVKRLPWGPGRSSSLFVYSFTSVADAYRFARATNMVHYVGQRDANKLEFLMRAHVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE11</accession>
    <name>A0A1Y2BE11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_478278</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BE11">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE11"/>
    <dbReference type="InParanoid" id="A0A1Y2BE11"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Region D6 of dynein motor"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="AAA_lid_11_sf"/>
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        <property type="entry name" value="DYNC2H1-like_lid"/>
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        <property type="entry name" value="Dynein_2_N"/>
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    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
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        <property type="entry name" value="Dynein_AAA5_ext"/>
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        <property type="entry name" value="Dynein_C"/>
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        <property type="entry name" value="Dynein_C_barrel"/>
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        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
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        <property type="entry name" value="Dynein_heavy_linker"/>
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        <property type="entry name" value="Dynein_linker_3"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
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        <property type="entry name" value="AAA_6"/>
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        <property type="entry name" value="AAA_9"/>
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        <property type="entry name" value="AAA_lid_11"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DYN_lid"/>
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        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="1925"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="2217"/>
            <end position="2453"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="2577"/>
            <end position="2727"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="2919"/>
            <end position="3085"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="3167"/>
            <end position="3243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="4607" mass="520531" checksum="FF750BC840A6DC8B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE59</accession>
    <name>A0A1Y2BE59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_521355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2BE59"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="234" mass="26522" checksum="5082B9B84360E116" modified="2017-08-30" version="1">MGKRRMPRVYLIRHGETEWSLNGRHTGTTDIPLTANGERIVKEMGPRIMGPGRLIDPSHVRHVIISPRQRAQRTADLIFGSNPPPKCYFQTDPDVAEWDYGKYEGKLTKDIRKEKPDWSIWDDGCPPGDTPGETPQQMSDRVDRVIAKVREIHAKAEKDAPTPEEIDNSDVMIFSHGHFSRVFIARWCNLPLQAGYHFAADAGGLAVLGYQHMTLKEPSLLGLNWYTEESLAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEA1</accession>
    <name>A0A1Y2BEA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA isopentenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_464259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEA1"/>
    <dbReference type="FunCoup" id="A0A1Y2BEA1">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEA1"/>
    <dbReference type="InParanoid" id="A0A1Y2BEA1"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="500" mass="55911" checksum="E88313C30C25491D" modified="2017-08-30" version="1">MLRSSRVLPGMLHRSSARQRPIVAVIGTTGVGKSDLAVSLAQTVPLSLVLSADSMQLYKGLDVITNKMTRQEMKGVEHWGLDLVQPGEGGSWEVGRWCGEADKIIASLDAQALPIVCGGTHYFIQHFLFPPSQLSFDRPPEQPLDKGKSPSTPIDVRWKPRRPRPETPSDLDPELSELLDTFWTSSPTWPGETSPASGPSTSRPSVVDDHQALSLHRLLTAVDPKEAGRWHWRDGRKVRRAIERWWERDGVDLVVTEEDSREDPKSAGRKARFKTLVFWVYEPMDTLRPRLDQRVNKMVENGLLREIAEMRQIATKMYGSSDAVDHTEGIFQAIGYKEFAALPLPQSDPSLDPVFPQMLAHTKIRTQQYAKSQLKWIRKQFLPALREARRLGGEVDIYVVRGGPTGVDGAREVLKSFLHDEPLPDPHTFGHPDAAALLGQLDVEAATAVPDIAQRQVLNSMTQCDLCSTAGQPFSLRTDEWELHLTSKTHIRSVNGSGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEY5</accession>
    <name>A0A1Y2BEY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_519739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEY5"/>
    <dbReference type="InParanoid" id="A0A1Y2BEY5"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="168"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="683" mass="76167" checksum="8297435CB5AB8101" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF98</accession>
    <name>A0A1Y2BF98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_520475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF98"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF98"/>
    <dbReference type="InParanoid" id="A0A1Y2BF98"/>
    <dbReference type="OrthoDB" id="2595969at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="282" mass="30152" checksum="D24EF888AC21281C" modified="2017-08-30" version="1">MNDPTLSPFSAPPPRYLVESDSSDEEGHGEYPGIGPSSSRQAPSEPIISIDLVVGPEEGLNAVLAVGQAGRYIVKKAGLTQVILRLKVDKTEVGRGYYIEGKEGKEVVVVFDTEGDKEWSFAAGEKLLHAIKAKSWTLVTTYAPQLYIHSSSSSSETDDPPIRCLVQQGRGSLPDTTEPYRSPNYVTGVVAAIVSLAAHPASPLEPSTPIQTLLLPLPLSSLPRQSLQSALSPSLPALSSRIAASNTQWTEDNDEAFTSFGQGRIVNNGRSARTEDGAGMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFY8</accession>
    <name>A0A1Y2BFY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_518851</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFY8"/>
    <dbReference type="FunCoup" id="A0A1Y2BFY8">
        <property type="interactions" value="811"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFY8"/>
    <dbReference type="InParanoid" id="A0A1Y2BFY8"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="453"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="658"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="832"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY33722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120084" checksum="3171335BB7A311ED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH29</accession>
    <name>A0A1Y2BH29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_462967</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH29"/>
    <dbReference type="STRING" id="71784.A0A1Y2BH29"/>
    <dbReference type="InParanoid" id="A0A1Y2BH29"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="116" mass="13240" checksum="45E8BA6A2E4C7B2B" modified="2017-08-30" version="1">MIRTQTTTLIRAPLAARSNGKRFASHGPVYHEPSGYLFAEKPPAKGQKRRKESWESIYYIGLFGTVAFGFVGYMYKPDSSIQSWALEEAKRRMEARGDLPKYVPSGYDVVRPYSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHG6</accession>
    <name>A0A1Y2BHG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_190422</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHG6"/>
    <dbReference type="FunCoup" id="A0A1Y2BHG6">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHG6"/>
    <dbReference type="InParanoid" id="A0A1Y2BHG6"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="37"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="533"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="708" mass="76440" checksum="D8B0DB896FA9FF17" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHH5</accession>
    <name>A0A1Y2BHH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_462727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHH5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHH5"/>
    <dbReference type="InParanoid" id="A0A1Y2BHH5"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="353" mass="38857" checksum="C4214B6F69202CA4" modified="2017-08-30" version="1">MHLLYRIKHQRSVLIVPDKDADGLSAGTLMYKTLRHLGLSPDSIKVHHLSKGANVHSDEERQRMEAFHTERSIVLDQGSRPGPPLLTSKGGEKRVLIIDHHMSTEFPRDAVILTACQTLPIATAALLTYVLLRRLWPDLDRVEGWRAIVGVVGDLGTTVAKWGRPPWPAELQEVVKQVGAKNVSDAVASINAPRRTADYNVPKAWDIYLHASHPSEVSRNAFFKLCRLEVKAETERWARTPPSFSLDARVAVITIHTGYQVHPVIATRWAGTLGRKSKKLLMCANTGFNPDPDKVSFSCRIAGSLRGLSENEKPDLISLLVEYGNAIPGFSDGVGADFARGHKEATGGVIPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHK7</accession>
    <name>A0A1Y2BHK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_517339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHK7"/>
    <dbReference type="FunCoup" id="A0A1Y2BHK7">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHK7"/>
    <dbReference type="InParanoid" id="A0A1Y2BHK7"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="316" mass="35006" checksum="A27A52B44B0A3AC8" modified="2017-08-30" version="1">MSGSEAKNTEPEESVVKETSVIKESPVEDSKVEVSELKDPAVKVPSAAPTPAASTSWISLRNILSISIIIIALLASPRFFNFDFGQSTPCETSYLILTAHPDDEAMFFAPTILSLVNAGCPVRGLCLSEGNESGLGRTRKEELVASYEALGVKKEFIEILDHPELQDGPTKDWPKFVIDNIVSSYLSMHHIDTIITFDQTGISQHPNHIAVSRVSAPRREIWKLQSPSILSKYTGPLSVISHYLPFSQSTSTTGKKGKKGKKAKVVKIKVFTTSPFGWARGVWAMTRHKTQLVWFRWLYLAASRLMWINEFEVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHN3</accession>
    <name>A0A1Y2BHN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_517550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHN3"/>
    <dbReference type="InParanoid" id="A0A1Y2BHN3"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="559" mass="61637" checksum="697FDE7230FE7B3B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI48</accession>
    <name>A0A1Y2BI48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_517227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI48"/>
    <dbReference type="InParanoid" id="A0A1Y2BI48"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012688806" evidence="2">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="133" mass="13979" checksum="983A24BC9BC25AA6" modified="2017-08-30" version="1">MIGGGTGLFLIATAFLSGANISRTAAIMTIACGSTYGVLHEVVEKTRNKLERPRPTEETLMTAFNADETTATTPTTSTASPASSREGSIAPVSEDLTRGDGGSDIGAQRSDDTTDESEEEEVLTMLTTTSSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI49</accession>
    <name>A0A1Y2BI49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_519186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI49"/>
    <dbReference type="STRING" id="71784.A0A1Y2BI49"/>
    <dbReference type="InParanoid" id="A0A1Y2BI49"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="37949" checksum="343D94A25B0BAFDC" modified="2017-08-30" version="1">MSAQPVTVSYPTLIADPTSLLPQIERAFGSSPGSLGIIVVSDLPPDFIKLRETLFHGAHALANLPESSRDALARPDTSYMFGWSHGKEVMNGRPDTMKGSFYANPMVDLPNVSAEKRKAHPEYYSGNVWPSDHTLSDFEPSFKALGEIIFNVGVALAKACEPFAAPQIALSGGKTLAALISESQCNKARLLHYYPETGSSDDQDRIANDALCGTHVDHSLLTGLCSAMYLASSNSSSSPTPTPVQAPSPTAGLWIHPRHHSATNAPIPDPVKVSIPPNCLAFQTGETLEILTDGKLAATPHFVSGNAGSSTGDSKVSRETFAFFLQYVQSLCLSQSSIYSFAMTFQADPTFIGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIE0</accession>
    <name>A0A1Y2BIE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_196813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIE0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIE0"/>
    <dbReference type="InParanoid" id="A0A1Y2BIE0"/>
    <dbReference type="OrthoDB" id="2563506at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="615" mass="65858" checksum="B4A057A46A6D5BCF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIE6</accession>
    <name>A0A1Y2BIE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_517866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIE6"/>
    <dbReference type="FunCoup" id="A0A1Y2BIE6">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIE6"/>
    <dbReference type="InParanoid" id="A0A1Y2BIE6"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="267" mass="28628" checksum="A2114033096A839A" modified="2017-08-30" version="1">MRPTLPSLIHVLIPVKRSIDYAVKIRIASDGKGVDTTVKHSMNPFDEIAVEEAVRLRERSPKLVTSITALTIGPPKATDTLRTALAMGCDSAIHITTPESSVVEPIAVARAIKTIIDRGVGESKSDKVDLVILGKQAIDDDSGSTGGMLAGMLGWGQGTFASKLEIEETGNVKVTREIDGGLEKIQGKLPMIVTTDLRLNEPRYASLPNIMKAKKKKIETLKPEDLSLDFTPRLETISVSEPAQRVGGGKVDSVDELVAKLKSAGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIM7</accession>
    <name>A0A1Y2BIM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_513835</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIM7"/>
    <dbReference type="InParanoid" id="A0A1Y2BIM7"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001496">
        <property type="entry name" value="Translation factor GUF1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="90"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1252"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="164"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1303" mass="145815" checksum="B6EEC56E732A6843" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIY1</accession>
    <name>A0A1Y2BIY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_514190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIY1"/>
    <dbReference type="InParanoid" id="A0A1Y2BIY1"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25389" checksum="E3620A276EA36A6A" modified="2017-08-30" version="1">MIQGFLHEAIEPGSKLSEHELTAWYEKEISSKIDGSIPELVSCAQYNAADEKKPSSLVVYETTSTSTSIEVLNKLRADNPVVVDRLEAYHASICEQIYDSGSTEQTRPYLMTGFMTPGQGDDEEFNQWYTQEHLGDMSKVPGWRRARRFRINDSIEKGTGKIPKAKATYAAIYELDHFDGLKSPEYHHACTTPWTAKMTGRCPVAEMRKWKLVKTWSTERTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ49</accession>
    <name>A0A1Y2BJ49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ49"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ49"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ49"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052732">
        <property type="entry name" value="Cell-binding_unc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883:SF1">
        <property type="entry name" value="GLUCONOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883">
        <property type="entry name" value="SLR0207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="375" mass="41369" checksum="1A3D18FE3DBAEE88" modified="2017-08-30" version="1">MSAHDSYSTTEAQIPLERQILLILVGLPGSGKSTFSNALVTHSLEPDWQSNTGTGTSFETGTGTGTGTTRRRKWIRASQDEAPSRRRQECEYAVRSGLENGFNVVVDRVDFDPKQRSHFIAIADQQTPRPQVHCLIFDMTHPTLEKRLIKRPTHPTIPDSETGLRVLGQMKAIWDPPRQNRSEGFDRVLVLDESGLPDNTLGECNTLNESNPPRTTLNESDSTQNDNENDHAGWSFHQVRRILDRLIVEGWEEIGHRISIDQERVQGREQRGGAWWARGGGGGGYRGGERGGYRGGESGLHRGGDRGGYRGGDGGGYGRGDRGGYGGGDRGGYRGGLREWDRGPYRGGDARGDRNGYGGGDRGFYRREHRGQGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJM2</accession>
    <name>A0A1Y2BJM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_195706</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJM2"/>
    <dbReference type="FunCoup" id="A0A1Y2BJM2">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJM2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJM2"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="252"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="316"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="589" mass="65802" checksum="14B00C74E08130D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJM5</accession>
    <name>A0A1Y2BJM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_515782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJM5"/>
    <dbReference type="FunCoup" id="A0A1Y2BJM5">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJM5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJM5"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="406"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="616"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="749" mass="83922" checksum="C2182E10343FB6E5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKK5</accession>
    <name>A0A1Y2BKK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_488933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKK5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKK5"/>
    <dbReference type="InParanoid" id="A0A1Y2BKK5"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="36"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="311" mass="33259" checksum="CD2FFA3EE704F78F" modified="2017-08-30" version="1">MSLCDIPFVSNKDGTSPKCDVFLPENATAANPAPVLVWWHGGGLLQGTRKGTAPHLQRAPEEHGLCVVSADYRLAPQSRLPDILSDVAALLSWLHSPAFAELTSFRASPSSGLVLSGSSAGGWLALLAGTGIGFQACSLPVPASPTAIIGLYPISDLGDPFWHTKQHPVSYMNRIISVSELETHGFLDPTAPKTTESELTGPRSIFYHYMVQEGILEDLLLGGTDLSQDSFAVAQSLRTGGYRAPPTFMMHGTIDDKVPIAQAEAVEAALREIGGQVELVKVVGADHLFDRDPASDLSRMYAFIRNVIPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKN0</accession>
    <name>A0A1Y2BKN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cryptococcal mannosyltransferase 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_461162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKN0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKN0"/>
    <dbReference type="InParanoid" id="A0A1Y2BKN0"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="297" mass="34359" checksum="D6A8F28632BA19B8" modified="2017-08-30" version="1">MHTTETDLALVGRDNVFVSIFESNSVDSTKPLLSTLNDSLSNLNVNHRIITNDDEARHWPYPQSRERIEYLANARNKAMEPLQSPDPTVRLENWNEYTTVVFLNDAWFSWEDVVRLIATETEDGGDYDLACGMDFGWLTERVGLYDTWVARDICGTPLRPFFPYVKDPVSARKVRDEQPFAVSACWNGMVAFPSGPFLCSLASPPLVTPLQFHPSPFQACDHSECFLMSYDLHRLYNTTERPARIVMNPQVRVAYEQNWWKWQNVVLRVPIIRFWVGKLEFLFPCCRIGEREGGRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKS0</accession>
    <name>A0A1Y2BKS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_585005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKS0"/>
    <dbReference type="InParanoid" id="A0A1Y2BKS0"/>
    <dbReference type="OrthoDB" id="2588346at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="379" mass="42477" checksum="AD3AE76F2A69295D" modified="2017-08-30" version="1">MSSSSSGSSHSVESLQRRVKQLEEAVDKYKKRGDPPQKVEQFQKSLEETKQLLREAKKEAAKPKPHPALQFGPVAQTVAIMCTISLGMSVVPLPWQMLPFYILFSRLTILAVICLVLYSSIIWYGYNSALVALNPPKDPNEEILEKLDKMMKPRPDRPDLWANNRAHPSAFLTTRHAPPRLFPFPLGKSRPEASVRDELWWEGGNAPHVGHFNRTTIPEPGIGSSELKKVLMERAMKRMEIEKQRKMWHKRIQSVQILCVVIALAFINKTLAIVILAWLIYSTLASEIDGMLAPPEDMTELHKKIKKIDDAAGKTQSGPRFRGRPGEVEGGMSYIFGPNGEASVEHVADVPIAMVPPHVLMTTNDHLRAGPGAEMEKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKY5</accession>
    <name>A0A1Y2BKY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_514498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKY5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKY5"/>
    <dbReference type="InParanoid" id="A0A1Y2BKY5"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="71" mass="7840" checksum="8C46A0EA4BEEC6E9" modified="2017-08-30" version="1">MISPHFAKLEDKYPSVKFVKVDVEEQEEIAQEQGIRSMPTFIVYKDGKAIETMSGAVPAKLTALIEKVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLF2</accession>
    <name>A0A1Y2BLF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_511086</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLF2"/>
    <dbReference type="FunCoup" id="A0A1Y2BLF2">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLF2"/>
    <dbReference type="InParanoid" id="A0A1Y2BLF2"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="14">
        <location>
            <begin position="62"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="326"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY35604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="82618" checksum="3DFC7095D80FA5B3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLG0</accession>
    <name>A0A1Y2BLG0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mu homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_510102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLG0"/>
    <dbReference type="FunCoup" id="A0A1Y2BLG0">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLG0"/>
    <dbReference type="InParanoid" id="A0A1Y2BLG0"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="436" mass="49980" checksum="4DF06E18202598E2" modified="2017-08-30" version="1">MASLVAILDVKGKSLITRSYRDDVPPSYIERFLPLVLDMEEENVQVTPCFSDEGINYMHIRHNNLYLLAMSKRNSNAAEIIFFLHRLCSVLTEYFKELEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEVQARPPMAVTNAVSWRSEGIRYRKNEVFLDVVESVNLLVNAAGNVIRSEILGAVKMKCYLSGMPELRLGLNDKVMFESTGRAARGKSIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLSTPVKPLVWVEASVESHRGSRVEYMVKIRGQFKRKSTANNVEIYVPVPDDADSPKFRTSVGSVVYAPEKSAFVWKIKQLGGGRDYLMRAHFGLPSVRNEELDKRAPISVKFEIPYFTVSGIQVRYLKIVEKSGYQALPWVRYITQNGDDYVLRTITDAKSSSIIAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLH9</accession>
    <name>A0A1Y2BLH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication ATP-dependent helicase/nuclease DNA2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BCR39DRAFT_461258</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLH9"/>
    <dbReference type="FunCoup" id="A0A1Y2BLH9">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLH9"/>
    <dbReference type="InParanoid" id="A0A1Y2BLH9"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000789">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14 27" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="24">
        <location>
            <begin position="26"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="25">
        <location>
            <begin position="626"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="26">
        <location>
            <begin position="748"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ORY35636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1058" mass="118110" checksum="809460F622D970CA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLP0</accession>
    <name>A0A1Y2BLP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative suppressor of action mutation 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_510087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLP0"/>
    <dbReference type="FunCoup" id="A0A1Y2BLP0">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLP0"/>
    <dbReference type="InParanoid" id="A0A1Y2BLP0"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="56"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="251"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="409"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="615" mass="68562" checksum="97ECAD93A227B341" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLT0</accession>
    <name>A0A1Y2BLT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_511754</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLT0"/>
    <dbReference type="FunCoup" id="A0A1Y2BLT0">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLT0"/>
    <dbReference type="InParanoid" id="A0A1Y2BLT0"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="697"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
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        <location>
            <begin position="747"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY35728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="870" mass="93718" checksum="C0F4B3740D241947" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM08</accession>
    <name>A0A1Y2BM08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_511159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2BM08"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7626" checksum="9CC3434328F5F0A6" modified="2017-08-30" version="1">MVLGKLAHYAFDAIAISTVLAGIKRSTGFTPDVKQLPESYIRNIAEGYLGAGETVFNVAAGQAVTSGYFKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM46</accession>
    <name>A0A1Y2BM46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_36408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM46"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM46"/>
    <dbReference type="InParanoid" id="A0A1Y2BM46"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="89324" checksum="6FEF526D364129FC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM98</accession>
    <name>A0A1Y2BM98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_585399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BM98">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM98"/>
    <dbReference type="InParanoid" id="A0A1Y2BM98"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1159"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="796"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1450"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1487"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1501"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1523" mass="170819" checksum="726C4C8316AB51F3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMC0</accession>
    <name>A0A1Y2BMC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_508673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMC0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMC0"/>
    <dbReference type="InParanoid" id="A0A1Y2BMC0"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="210" mass="23399" checksum="8B1DB29ADE6B2683" modified="2017-08-30" version="1">MALSFLAPSLGPFQRPIVDHKDGSWTFFGGDFKTWAVSGDEDHFKSRQIFKANSPHTGAGRGSTATPPYHMHPYQIETFEVLSGTLCYCIDGKLGKLESGKSVVIPKYQPHTFWNDPSTGTDLDVYITVRGGENPGFDETFVHNFYGYLSSVTMAGKKPNPLQMLRFLDHANVILADPPYLVGRMLNLLLGRWLGGYIFGYKTEYGTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AD23</accession>
    <name>A0A1Y2AD23_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eisosome component PIL1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_475043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000138">
        <property type="protein sequence ID" value="ORY20374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AD23"/>
    <dbReference type="STRING" id="71784.A0A1Y2AD23"/>
    <dbReference type="InParanoid" id="A0A1Y2AD23"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000096">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF6">
        <property type="entry name" value="EISOSOME COMPONENT PIL1-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY20374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="643" mass="68816" checksum="5741BE9812FA972C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE34</accession>
    <name>A0A1Y2AE34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_554685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000124">
        <property type="protein sequence ID" value="ORY20829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE34"/>
    <dbReference type="InParanoid" id="A0A1Y2AE34"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="257" mass="28345" checksum="EBCC190C5B670EAC" modified="2017-08-30" version="1">MGRKGILCISTTMPVSFGHIRFIPRSPRPGIRADDEIVPFSLYRFDHCSGAFSTPEAMLAHYDETHLREPVIDELRGRKRRRMSRRGEYELVPEEFRLADEIRIRHVDSQTTGDVTTTTTNTTLSHPLPPSFGSLPASFPNALPTDFILPPREIIMEEVQVDYGSFLQSPSPERNAMPPPAPSPFVPITQAQPPSAQQPLPQSPDISRSRAGSMGSQAGRKSLAFGAALENETLKPDTPEKGRSAVGGVGFTWGLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHI7</accession>
    <name>A0A1Y2AHI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_569301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000105">
        <property type="protein sequence ID" value="ORY21750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHI7"/>
    <dbReference type="InParanoid" id="A0A1Y2AHI7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="180" mass="20015" checksum="7A93A341A28B7461" modified="2017-08-30" version="1">MAKSGLMHNAIKCMLCLLLCSFHWVVILQYKYQLKGVVTNLSLQGLGAWKDLLQAEVNEDSDDSIYYNKLSSAAEFSVTPIRRLRSMQGIGDRGDQYGRRNDSDQGEMPLLLAIVNGNKSNGWLFGSGPGRVMTKKISVCNRSNECSWRLSGWVFTLGILSRGLSGTCRNTGGLDQQWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI26</accession>
    <name>A0A1Y2AI26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_551866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000096">
        <property type="protein sequence ID" value="ORY22231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI26"/>
    <dbReference type="FunCoup" id="A0A1Y2AI26">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AI26"/>
    <dbReference type="InParanoid" id="A0A1Y2AI26"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="36"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY22231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="611" mass="68332" checksum="9B9539A0AB044CC2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIN5</accession>
    <name>A0A1Y2AIN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_385195</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIN5"/>
    <dbReference type="FunCoup" id="A0A1Y2AIN5">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AIN5"/>
    <dbReference type="InParanoid" id="A0A1Y2AIN5"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="58"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="269"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="555"/>
            <end position="564"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY22443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="748" mass="82487" checksum="A5EA3F6AC55ACB9D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIR3</accession>
    <name>A0A1Y2AIR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BRCA1-associated protein 2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_487923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="BRAP2/ETP1_RRM"/>
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        <property type="entry name" value="RING-H2_BRAP2"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="BRAP2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="346"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="383"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="131"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="553"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY22384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="76272" checksum="B5740D41C617D97C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIU0</accession>
    <name>A0A1Y2AIU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_601105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIU0"/>
    <dbReference type="InParanoid" id="A0A1Y2AIU0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="197" mass="22546" checksum="D7F7C5A3D0BB9B29" modified="2017-08-30" version="1">MEWYRSSPWAAGLKSRIIAAQSQRSRTNTERHKYVQQQKITPRCSVNSENASALQLVPILTKVSWNEEMSIVSRWRRVWKTPKKTSITLTFRLEARTIQDPFKSMGRAFQREPKLDRPLPDDTDAAELERVLSDAIPQLSDSRRYTETIGTTEVGEDQKCTWASIPGDPTDVTDNISRDLIIHLNVPRKHDGSLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ70</accession>
    <name>A0A1Y2AJ70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Trafficking protein particle complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_551248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000090">
        <property type="protein sequence ID" value="ORY22633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ70"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ70"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ70"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="729"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1190" mass="131442" checksum="24427DF746F5B5CB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJP2</accession>
    <name>A0A1Y2AJP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Short-chain dehydrogenase/reductase SDR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_371854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJP2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJP2"/>
    <dbReference type="InParanoid" id="A0A1Y2AJP2"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY22771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="27549" checksum="9440202178BEBE24" modified="2017-08-30" version="1">MSTPPRVILITGASSGIGRTSAIAVSNAFPSTSNPEPLVLILSGRRESELKETASRCREGTVTEICVGDVSKDADVEKMFKTIKDKYGRLDVLFNNAGIDLLNSVPLEEADMDKFRQVLDVNVMAAVLCTQGAIKLMKDQSPQGGRIINNGSISASSPRPNSAAYTVSKHAILGLSRSTSLDGRKYLITCTQLDIGNAQTAMGGHAAKGSRQADGSMRPEPMMDVSNVGKTIVFLCALDPGADVLSMEVIARGMPYVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKV7</accession>
    <name>A0A1Y2AKV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_364147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKV7"/>
    <dbReference type="InParanoid" id="A0A1Y2AKV7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="298" mass="31643" checksum="88C34F1259497C80" modified="2017-08-30" version="1">MGSVPTSPSASRRSLSPPPYSPTRLPLTTDHNIRQSHMSGTDPPSVNQSPAESSRRTHLQPSSPSASTVSSATDDPSTAPTTPALDAPRTWRPTSNVPLYMSQRRARHVAGDEDEERNRWLSDGEGLDGVARSIGRRSRRAHGRDRDRPSYSPGPSQGPASGAETPPQAKARQPTQLNKMARPANRRSRSFEPSAAGPSTVQASEPDSSMYAAPPRIEDLVPSAVVGLGVTTGGASSGIEHFKESGNVPDFVAGHGGDGIGGVSLPSSRPSAEFSATEPQPREAQRELVQKLRRVLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALD8</accession>
    <name>A0A1Y2ALD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_550069</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALD8"/>
    <dbReference type="FunCoup" id="A0A1Y2ALD8">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALD8"/>
    <dbReference type="InParanoid" id="A0A1Y2ALD8"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="62"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="257"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY23037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="43127" checksum="2E6E9115B996CC48" modified="2017-08-30" version="1">MPPSETTALLPPTGRNGLSQPKKFDPIGSSRHLIFGSWINLLLIAVPLSIIADLLHWNAAARFSTSFLAIVPLAKLLGDATEQLSMKLGQTLGGLLNATFGNAVELIVAVAALNQNELRLVQTSLLGSVLSNLLLVLGMSFFAAGFFYHESTFQATAAQASSSLMTLACITLILPAAYHASETDGTLSLFSSEGAPDPHDKSLRGLLVLSRGTSIILLLTYIGYLFFQLRTHSALFEAEQTDEDEEVADMDQWSAGAWLVIITVITSFCADVLVGSIDETAEQWHIPKRFIGLILLPLVGNAAEHVTSVWMACKGKMELTIGVSVGSSIQIAAGMIPLLVIIAWPLNKDLTLFFANFETIVLFVSVMLVNLLLQDGRANYMEGVMLISLYLVIALSYIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALH2</accession>
    <name>A0A1Y2ALH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNH domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_549382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALH2"/>
    <dbReference type="InParanoid" id="A0A1Y2ALH2"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="711"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="938"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1172"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1371"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1794" mass="200066" checksum="96268E7864D43B29" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM07</accession>
    <name>A0A1Y2AM07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM07"/>
    <dbReference type="InParanoid" id="A0A1Y2AM07"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="95" mass="9245" checksum="0E1DFF71225092A2" modified="2017-08-30" version="1" fragment="single">MMNPMMMGMMNPMMMGGMGGMGGMGGMGGMGGMGYGMLGGGLGSGAYGMPRYPPGGMFGDYGMGMGAMPGGMMGGMGTGMGGYGMGMGGMMPYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANZ9</accession>
    <name>A0A1Y2ANZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANZ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANZ9"/>
    <dbReference type="InParanoid" id="A0A1Y2ANZ9"/>
    <dbReference type="OrthoDB" id="2422840at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120134" checksum="9E1F5F14AF7282BC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQC9</accession>
    <name>A0A1Y2AQC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_595232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQC9"/>
    <dbReference type="InParanoid" id="A0A1Y2AQC9"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="174" mass="19049" checksum="1286062E6AAFA7F8" modified="2017-08-30" version="1">MVSLRISDNAVRITHSVLFGITLLISIIALGFSGSLVGHYNSDGYPKEHTGAYRDRIRILLVASVWTTAFAIILVIGFQLLGRHRAFGLLSHLVTITIGFILFLVGSASLTALTDKISCGVKSQGFSRCNIVKGLVVISWIDTIFLLLCLIFLIVLTLADRGAYGVHRRTLYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQI0</accession>
    <name>A0A1Y2AQI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_321864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQI0"/>
    <dbReference type="InParanoid" id="A0A1Y2AQI0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="81" mass="9243" checksum="EE90F1857B128BD5" modified="2017-08-30" version="1">MPRLPLLLQAARNASRGQGVLQDLAPAACLVRKKRHQHRRSRCAHEGEIRYSCRLAFAHNHVDSIVQATRYPDLTLDALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQK0</accession>
    <name>A0A1Y2AQK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_471941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQK0"/>
    <dbReference type="FunCoup" id="A0A1Y2AQK0">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQK0"/>
    <dbReference type="InParanoid" id="A0A1Y2AQK0"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="388" mass="42335" checksum="BCDD4990F93DE09B" modified="2017-08-30" version="1">MISSYPHYDGASLNTFSRIDDSQNHSTPFGISIPQSSPPLSYASASTSASASASASASSSSTPSSSPPMPPFAVFEYDGDNDNDTERALSPYANGPIEIVPGVFLGAEESVFQVSAWGRGKRRVRVLNVAQEIEDPFASQRPHVDNGKGKERASVQVDRYPPSPGKGWPKMDYCHLKWSHGEAGLAGIPDQSTLDDFINPREPEVGDGNWGLWTAILYIEDARRRDIPVLIHCQCGVSRSATLIIAYLMALAASGLEPDLFGHLSGMQDAYNFVKSKSPCISPNVSLVFQLVEFARNVTTLLCRYPSASNIRTAWPKREEHEMSEAEWARRRAAFDDESGIGNGNGTEDSDGQGDDDMAMLASPMSIDEAEEEARYLDEAMRKRKGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQR2</accession>
    <name>A0A1Y2AQR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_499960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQR2"/>
    <dbReference type="InParanoid" id="A0A1Y2AQR2"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="539" mass="59159" checksum="A3457FB60B3D6958" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARG4</accession>
    <name>A0A1Y2ARG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_305348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARG4"/>
    <dbReference type="FunCoup" id="A0A1Y2ARG4">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARG4"/>
    <dbReference type="InParanoid" id="A0A1Y2ARG4"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="40"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY25153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="495" mass="53572" checksum="02B8EDF5C4DB0355" modified="2017-08-30" version="1">MSQDYGTTSASPPRSSSTTLAASSPRPTPGPGGVKQDGHASVLSSVTNLTNTVIGAGALAFPSAFAAMGLLPGIVSCAFSACTTIFGLYLLSRCATMVGKRPGEEGRKASFNEVARLTFGKGWVIRLFDLAIIIKCFGVSVSYLIICKTLLPQVCMTFSRVLRHPLSEHSILLSQDFWLVAVMFVIVPLSFLRTLDSLRFTSQIALVSVAYMIIVVVGWFVLKGVSPTRGEVRLGRFASNTLSSFPVQVFAYTCAQNIFPIYNELKDKTQKRMNTVIFTSIGSACLCYEVLGIIGYITFGSKVGSNIIAMYPASSVFIALGRLGIVLLVGLSYPLQLLPCRECVNTLTSPIKRRHHPSTTVAGPEQVEPEDDDDEQDEEDPLVPKDIDDGHGHASAAGMSNLRFMIITIGILVSGFIVALSVDELEVVLGFVGSTGSTIISFILPGAFYYTAHRDKENKTKWWALLLAMYGCFVMVFCLTFNILHVIHHDGPAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARM9</accession>
    <name>A0A1Y2ARM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_499610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARM9"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARM9"/>
    <dbReference type="InParanoid" id="A0A1Y2ARM9"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="88"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="502"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="638" mass="70020" checksum="CEA9C4D8B71CB721" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS03</accession>
    <name>A0A1Y2AS03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_289245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS03"/>
    <dbReference type="FunCoup" id="A0A1Y2AS03">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS03"/>
    <dbReference type="InParanoid" id="A0A1Y2AS03"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="104" mass="11813" checksum="A766E36AD0A4604A" modified="2017-08-30" version="1">MSNRTVLYVTGFSANLRARDLAYEFERYGRLIRCDIPALKSASSAPFAFIEFRREDDAEDAYYDMHGRSIDGRRISVQWAKRPPSSAWRHDGVSGEPPISLSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS68</accession>
    <name>A0A1Y2AS68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_485517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS68"/>
    <dbReference type="FunCoup" id="A0A1Y2AS68">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS68"/>
    <dbReference type="InParanoid" id="A0A1Y2AS68"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="220"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY25326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="721" mass="80203" checksum="6E566C242130A0C9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASS5</accession>
    <name>A0A1Y2ASS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_285759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASS5"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASS5"/>
    <dbReference type="InParanoid" id="A0A1Y2ASS5"/>
    <dbReference type="OrthoDB" id="2569636at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60310" checksum="842654270F5542AA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATB9</accession>
    <name>A0A1Y2ATB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_543054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATB9"/>
    <dbReference type="InParanoid" id="A0A1Y2ATB9"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF40">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013028169" evidence="7">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="94" mass="10067" checksum="F80B693E1FDA8EB6" modified="2017-08-30" version="1">MVKGSDILLIVVAIIFPPAAAAMITGCSCDLLINILLTILGYLPGHVHAFWLIYKRIKAEEAYGIHGYTYLGNGNFVGTGGAPPPPQQYYGSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATC1</accession>
    <name>A0A1Y2ATC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_471139</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATC1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATC1"/>
    <dbReference type="InParanoid" id="A0A1Y2ATC1"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000097">
        <property type="entry name" value="Potassium voltage-gated channel subfamily G member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="153"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY25736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="552" mass="61244" checksum="2AF9D9492B67D402" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATF5</accession>
    <name>A0A1Y2ATF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_542955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATF5"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATF5"/>
    <dbReference type="InParanoid" id="A0A1Y2ATF5"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="858" mass="95431" checksum="9442218C8DC03CD0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU16</accession>
    <name>A0A1Y2AU16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_542398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU16"/>
    <dbReference type="STRING" id="71784.A0A1Y2AU16"/>
    <dbReference type="InParanoid" id="A0A1Y2AU16"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="290"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="512" mass="53015" checksum="FEFE005292B91AA2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUF4</accession>
    <name>A0A1Y2AUF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_541508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUF4"/>
    <dbReference type="InParanoid" id="A0A1Y2AUF4"/>
    <dbReference type="OrthoDB" id="3361009at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="111" mass="11726" checksum="B40AA0D64C4C0552" modified="2017-08-30" version="1">MTSYNPAPIETSEAILPSKQSTGTSTTAEFSATPQSGNGIPPSVVADVDYPNVQDTTESQQAATAPGAGGVVEEKLPFKEQVNGYAKKFAGSVFRNKDEKEFGEKKLQGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUI9</accession>
    <name>A0A1Y2AUI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_560690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUI9"/>
    <dbReference type="InParanoid" id="A0A1Y2AUI9"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="213" mass="24441" checksum="EB6937D12F6764CB" modified="2017-08-30" version="1">MREYPTPDSPSPPRRVSDLVTRHYVSPSPELSERDTVSGSGRPSPIRRVSNEGREVITHFKRHSHSHPQSHSHSPIPHDAIPQSGEQAYHPSLPLRTQGHPHPYQRPPLELARVPRIPPVPHGYYRDPLHTSGHDLEEWERQEERVAKSRLSHIQSEQRRRESINGGFKQLRSLLPDATEESTKAQVLQMACAYVLRLENTIRRLSDGQYGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVJ3</accession>
    <name>A0A1Y2AVJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_578826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVJ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AVJ3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="474" mass="53056" checksum="87BC48D636278D5D" modified="2017-08-30" version="1">MSEGSALCLLETDHDYGKNEDGNDEVCYDDEDQEEETEQRDHDENDEVDENDENDEKDDGDLHGEGNLDDSGEGNSEEETGSGEDNDWTIEAPRSSSPPCLTTEDTQGLWLGSLVYRLLPRTGLLEGETDTYYRCDSSARTSRWDEEKMICSAKCSQLPALKCRWSEGRIDGTVLNRQAVLCRTHLDELLERPVPFSTYRGPDYIQSYRQVGELCSMYDCQEAGHSWTRKTASGKSTTQMCDKHVSEIAASNSTGPVLKPRLRDLYSKAMAARKDSSIDEMPSEYQTFLDHLCLGVGPEIETEGYQPVPTCFRAKHPNSLYCPRDQRYLNECWLSGVTPQCRLQVKSHCSNPMSDPTSGLCSEHRKAFQISNCCITCNAETSSVSSPSNTAPSLSIIAGMCSNCLRTSGVETILPGLADSLEFQRTPQGMPLEDDGGYTSRLKSTMSELTYWTPPYVQRERERRREALKASQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVJ5</accession>
    <name>A0A1Y2AVJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_256661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVJ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVJ5"/>
    <dbReference type="InParanoid" id="A0A1Y2AVJ5"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012011046" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="370"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="477"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="582" mass="62615" checksum="5AC1138AEEC52302" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVP8</accession>
    <name>A0A1Y2AVP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_540751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVP8"/>
    <dbReference type="InParanoid" id="A0A1Y2AVP8"/>
    <dbReference type="OrthoDB" id="2565027at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="565" mass="63191" checksum="0AF53B67B3D6AABF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVU8</accession>
    <name>A0A1Y2AVU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L18e/L15P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_540475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVU8"/>
    <dbReference type="FunCoup" id="A0A1Y2AVU8">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVU8"/>
    <dbReference type="InParanoid" id="A0A1Y2AVU8"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="120"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="300" mass="33171" checksum="8C0974798F29AC0B" modified="2017-08-30" version="1">MSFRSLSTAFSALRLATSRLQPVNVAPFQVAAFASSSRLKAHYVGLDSLSPARGSTKERKRVGRGHSSGHGRKSGRGDKGAGARTGQKIPYLGFEGGQTPFWRRAPKRGFVNAFAKKLQPLSISRLQQWIAAGRIPTDEPITIRSVVQSNLVHGLSKKDGIKLLGNPDPSLPLPPLTIWLSAFSENAAKSIIDAGGDVKAVYHNKHSLWFELHPDKFKGKGYSAPRPIRRRDIMFYTDPKNHGYLADVKDEFIASLGFNPYFVKGREKDVDENAPIRGKWDVRVSRELYAGQELVPVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW28</accession>
    <name>A0A1Y2AW28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_540246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW28"/>
    <dbReference type="FunCoup" id="A0A1Y2AW28">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AW28"/>
    <dbReference type="InParanoid" id="A0A1Y2AW28"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="384" mass="41675" checksum="C14AE445ABF904F4" modified="2017-08-30" version="1">MTVTAASRLFEPITVGAIPLKHRVVLAPLTRLRANKETGVPSDLAIEYYRQRASDGGLLISEGTMIAQEAGGMPGAPGVHSKEQISKWKEITDAVHSKGGKIVCQLWALGRVADPSLVSTVWGASTLPFVQDGQSPSEAPKVTQLTPKDIERFTGHYVQAAKNAIEAGFDGVEVHGANGYLLDQFLQSKSNNRTDEYGGSLENRFRFPLAVINAVSKAIGVERVGLRMSPLGTFQGMREDDPIGVFLPWAQTVLAAQPKIAYIHAVGPRPEGLKDADEYDTLMLVSGNLDVIRDAVVKAGSRFLIAGGFTTKSAKAHTEQTDDLIVFGRPFIANPDLPERIKNDWPLTPYDRSTFYTPDAHGYTDYPTYKEEGSQDALAPKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXN9</accession>
    <name>A0A1Y2AXN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CNH domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_540370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2AXN9">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXN9"/>
    <dbReference type="InParanoid" id="A0A1Y2AXN9"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="831"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="1213"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="649"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1593"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1602"/>
            <end position="1612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1612" mass="176987" checksum="21C74E1925EA0BCB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXW7</accession>
    <name>A0A1Y2AXW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_506295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXW7"/>
    <dbReference type="InParanoid" id="A0A1Y2AXW7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="314" mass="34447" checksum="EEBCBC09D7962229" modified="2017-08-30" version="1">MSTDSSSAQANDSSGPGAISSESGLVYRWSPEMYVDRFGPLDVGLRLRVQFMEDTRQDRGARQSAEVAARTREADVDCRSGLQKVLESYDANHPNVTASYAETADRLSPIDWWASSVASLVGAYGPTREDEVTRGRYVFRKWRIEKDAYCYGGAATEEVLAAFTRGSTEVLRTTATVSPYISVSGTTLGLHLSANLGDPTFADSVSTVDKELTMRRLKAVEESFSNTFEPSFAKTLRNSFASEPPATDFTPGTMLSLGMVQQWTTAVENRIRAAGLPEITVRPAELIVKIDLDYEDEGTRSAFVPYGGQTNRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY41</accession>
    <name>A0A1Y2AY41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_565716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY41"/>
    <dbReference type="STRING" id="71784.A0A1Y2AY41"/>
    <dbReference type="InParanoid" id="A0A1Y2AY41"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000046">
        <property type="entry name" value="Geranyl-CoA carboxylase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="342"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="596" mass="63957" checksum="2BD986ED972B59F2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYM6</accession>
    <name>A0A1Y2AYM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Eukaryotic mitochondrial regulator protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_537914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYM6"/>
    <dbReference type="InParanoid" id="A0A1Y2AYM6"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="354" mass="40065" checksum="667D6FB70270811F" modified="2017-08-30" version="1">MSAIAGPSRIPWNITRQSRLFSSSSRRRAQRPDHVESEEVVRAKLRDRGYHLGVTRYLNSLAEEFAHPLPGQKAKWLGGNHPYPLNPSFRPPPPLGNQTQDFIYQELCRGVKTTGALAAEFNVSKARVEAIRKLKEVEQEFIRQGLPLQRAFLEAMEPLLGNAASASIRNRYDQQLHVDIAARAEDPATIVELEEEHRFDAGIGDTGAFGDPALASKEGTQLPAFELRDEDLSAAVRRQQQAESQAAEEAAANGEKVEINQGEWTAEQQAFPNPGYVKEKLDFAKREERLRREEKVLPQTTFTPSSGRTWRFVDVSSEKQKQAGVVQRMEKKREKRREKKQQRKDMERLAKAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYW9</accession>
    <name>A0A1Y2AYW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_219041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYW9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYW9"/>
    <dbReference type="InParanoid" id="A0A1Y2AYW9"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="115"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="236" mass="26715" checksum="F754A7FEBDEAC73B" modified="2017-08-30" version="1">MFQGHRLWIERRRYSDAYGYGVDHLRIKTIFYQSSAIEDFLVSVHGDYFRKADDELMIFHASPWSGSWYDPISRPARHWDSVILPPHIKNGLLADVKDFLSEGDRAWYAARGISHRRGYLLHGRPGSGKTTLVTAIASQLKLSVRVISPAARGMHDQKLNLVFRSCNQGDLILIEDIDCVMPMKRQNDNDDGLFEAEEKDSKNKNYLPRSTVTLSGLLNAIDGVSSQEGCILFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ80</accession>
    <name>A0A1Y2AZ80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L22e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_536539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ80"/>
    <dbReference type="FunCoup" id="A0A1Y2AZ80">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ80"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ80"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="123" mass="14074" checksum="EF0911AFE2FEE428" modified="2017-08-30" version="1">MPKAQTAAKSAAGKPLHKFYVDYSVPAGDNVFDPASFEKFLHDRIKVDGKPGQLEDNIVISKEGNKLVLTSQIPFSKRYLKYLTKKHLKKNNFENFLRVVATSKDTYSLRYFKVDQDEADDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZM6</accession>
    <name>A0A1Y2AZM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZM6"/>
    <dbReference type="InParanoid" id="A0A1Y2AZM6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="31199" checksum="4109A5AE29BE83A4" modified="2017-08-30" version="1">MGRRNPVVVYERIGNPFSTFFGKESLPDAPSLSCLPLLTSNNDPAIYADPTSEVAMGSQDLFDAGTSAQTTPALSDFDASRIRSDLSNRSAIQSTAPESANKLESVFIGLVDGEENAIRVVTLNDEFFGSAAWQDMKADLEALCSLMPEKPWDQVRSEISQRWATRVSVNLDPDDDPSISPSSLDRGQSKGTQGSLPDVHTRDFSSYQSEVAFEDMRTASRVVRGAKIEDSLQSRGARANGRTTRYPLPSLASTKPYGKQTSTVWRGWRGRALHLLGSFAPYAPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZY8</accession>
    <name>A0A1Y2AZY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_535807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZY8"/>
    <dbReference type="FunCoup" id="A0A1Y2AZY8">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZY8"/>
    <dbReference type="InParanoid" id="A0A1Y2AZY8"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="169" mass="19348" checksum="E9977A5E7515A167" modified="2017-08-30" version="1">MSNTLRPYLNAVRATLTAALTLENFSSQVVERHNKPEIEAATSPEVLLHPLIVSRNESERVLIEPSVNSLRLSIAIKQADEIEKILCHKFTRFMMMRAEGFVILRRKPLPGYDISFLITNFHSESMLKHKLVDFIIQFMEDVDKEISEMKLSLNARARIVAESYLATFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B006</accession>
    <name>A0A1Y2B006_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_535894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B006"/>
    <dbReference type="STRING" id="71784.A0A1Y2B006"/>
    <dbReference type="InParanoid" id="A0A1Y2B006"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="217"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="370" mass="41511" checksum="FF03063CD5A10D3F" modified="2017-08-30" version="1">MSPIAIDTPTPSDGAATIVKPPKIAEWVAPPLTKQDLPWADLETLDLRLLDSTDPQVRAQLVKAAKKALTVDGFLFVTGTGVSDETLKRNLAIAQFLTTGIPQEDKLPYAANLDGGSYEGYKLRGIWKKEGGVADNIEHYNLESSSFENPQGQHPPQLLPLLSEIQAFAEHTYRHVVYRILKLVSLALELPEDYLWGLHDQRGAIGADCQRYMGYFPRDDEQEQATGGIWSKGHTDYNSVSLLYSQPVSALQILTPEGQWRWVKHVEGAVVVNTADALEFLTGGVFKATRHRVVRPPSDQANINRYILIHFARVRRDLVLNPIWDSPLVKAKGKHSFQERIDAGGSAPTQDEWLRERIRRTGRELCEYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B074</accession>
    <name>A0A1Y2B074_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mis12 protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_208631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B074"/>
    <dbReference type="STRING" id="71784.A0A1Y2B074"/>
    <dbReference type="InParanoid" id="A0A1Y2B074"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35884" checksum="1BFB1B2C5AFF395B" modified="2017-08-30" version="1">MPPRKSALKASRSSQAATLPEKTVASSSKTTLDDIPPPSIPESVTPGYEWEERPRQPLSEEDRMQLIHELVSFHPRTILDQITEAARDVIYPIVGGIEGWGEHQAEGMGEDVDRELAIGLHALETLFETHVDKAFDRFTAWCLRNAFDVPADLDVVLPWHAGLDFQRGEHVAALPKGEAGVVESLDQLRGRVEQMRLLSQRLEGAEKILDRRLEIAKQRKAEIGFVQEVLASSGLSPLSPKVSTILSSLQSLHTTLQPLEIQHPTLAPPALNGNGKAWELGRSAYLNWAVGKMVGGAAGDGEGRLEGVEKELGSVGDVEGVERLGKAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0C0</accession>
    <name>A0A1Y2B0C0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_210537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0C0"/>
    <dbReference type="InParanoid" id="A0A1Y2B0C0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="223" mass="23509" checksum="167CC7F0EBBB6BE0" modified="2017-08-30" version="1">MIDSKVHCSASHRDERSVGNNSFVCCGAIAPSSSLYNSRACGKGTIITSSTLHDSIACCGAVVRSSTATGSRFCGSRHDSHGKHIGDETDICEVRSSTVTKCKVGLGLISSSTVTSSTLGECTIKSSTVASCIMFDILRTSDSTGGDRSGKGRFDFSPHYVPSKKGRHDGGHGGHGDHDHCVKNIQDEDMAPPYSLTANEKTPLITEEQFATDTTPSRCCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0K6</accession>
    <name>A0A1Y2B0K6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_535197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0K6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0K6"/>
    <dbReference type="InParanoid" id="A0A1Y2B0K6"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="77"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="526" mass="56860" checksum="05417029890716ED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0T4</accession>
    <name>A0A1Y2B0T4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_468244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0T4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0T4"/>
    <dbReference type="InParanoid" id="A0A1Y2B0T4"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013276971" description="TM7S3/TM198-like domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="118"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="730"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="780"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="730"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="808" mass="88305" checksum="2A19AA5BBA72DF5B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0W2</accession>
    <name>A0A1Y2B0W2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_448591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0W2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0W2"/>
    <dbReference type="InParanoid" id="A0A1Y2B0W2"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="96" mass="9801" checksum="0D4AA7D92F145778" modified="2017-08-30" version="1" fragment="single">VPNLELHSAAASGNVGLVHYALTHGQPVNSVLHGVLPLHAACSGGSVSVVRMLIERGADVNAPRLPRRYSDGRKPNVPSVGAAGSTPLHFAAANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B190</accession>
    <name>A0A1Y2B190_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_576615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B190"/>
    <dbReference type="InParanoid" id="A0A1Y2B190"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="156" mass="17392" checksum="B9B05735A763F215" modified="2017-08-30" version="1" fragment="single">LDDLPISAYAPQYFCAHHRLSPTLHQVPRNAHYLSLHTKSCQSPNPPRPESQSIPESSQVSISLLNGIRRMKAGKTGLRLYGSTPTGSTEHIGIIRWRRINKSAFSALRPQSHLLSMGPMNGCAMISRMQAKQQMENPCHRTILLGTRSQVELALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1E9</accession>
    <name>A0A1Y2B1E9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_482398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1E9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1E9"/>
    <dbReference type="InParanoid" id="A0A1Y2B1E9"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010983817" evidence="1">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="289" mass="30252" checksum="0CDB4587908B1528" modified="2017-08-30" version="1">MKYSAAAVLLAATAAVALPAKRAISDTDILQYALTLEHLEDYFYHNFLDQFDQAAFMAAGYPDWVRNRVENIAQHEAQHVALLSGALGSAATQPCTYAFPGVTDPVSFMATATLIENVGVSAYLGAASSITEAAYVTVAGSILTTEARHQGWFSSSVDMGPGWSGPEDTPLDFSEVYSIASAFITSCPSSNPTLPVQAFPALSIAADGTITTTASTDGTYVQVIAGLITDTFPVSGGKVANLPAPQGISYAVLTTQSNTTLVSDENIVAGPFIMNNPFLSKFANPAPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1K8</accession>
    <name>A0A1Y2B1K8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_534493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1K8"/>
    <dbReference type="FunCoup" id="A0A1Y2B1K8">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1K8"/>
    <dbReference type="InParanoid" id="A0A1Y2B1K8"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="131" mass="14347" checksum="17B4A117857C8709" modified="2017-08-30" version="1">MADVEMDTRTNGSADEHGWAAKSVEGWIIIVTGLNEEATEEDLQDLFGDYGEVKNLSMALNRRTGYVMGYALIEFATKEEAEKAIKGTNGTTFLEKTISTDFAFSKAPAGARRAPAPRRTGRDRSVSPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1Y0</accession>
    <name>A0A1Y2B1Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_575544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1Y0"/>
    <dbReference type="InParanoid" id="A0A1Y2B1Y0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="372" mass="41329" checksum="E9B404E65D78942D" modified="2017-08-30" version="1" fragment="single">ELEQKSLTATVSQLRRAHCLRPCTACVSWHSRPYLKRQWLYEALHRSFNSRRVYQGVQICNAPDHRLFLPERRATWTLPVLAHLYETDCHPLRLALILILQFSPLFGFGIPFLWRLTSIIMTESDGNETPMIGSEVDDLSDEGLSHSGDERPSESESDAGSPDSYSVGGSSDVLSISAWAKRLEEKSPTPSNFTNPTSSSLWDETSMASTGPSTQPSLNKARPISVYCSMAEFDQSSYDTLRQWPQQRGSHLGSAPFERMISRMISEAALRTESGTLDPYVVTVIEGDISFSSSIEAGTDRKMIKIRVPEDSVPSKPSVTTVSRGPSAWVPGSLSPLAEKDEQDGEKRVHCQQDDEIGDDDDDDDDEDPDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2R0</accession>
    <name>A0A1Y2B2R0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_598805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2R0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2R0"/>
    <dbReference type="InParanoid" id="A0A1Y2B2R0"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="517" mass="57494" checksum="660A1849B7F65463" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4I9</accession>
    <name>A0A1Y2B4I9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_160770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4I9"/>
    <dbReference type="InParanoid" id="A0A1Y2B4I9"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36883" checksum="B6BD5AE410851F26" modified="2017-08-30" version="1">MPGTRTSPDELDIETGFLLFASISTLGEQWFSYAEIRQTMRQMRTRGGFERDEDCYLDVKGRQLGIPGICSWDSDPIYIGPSSGSSGGSSGSPPNLPPIGHEQERLRQGSLSPEVFEALAYPGPRQEAAMRAVNEEWQRARPSVRHPPSNVPRSLPVLPAAFAHPPTPFAPPPTPVPSAPSHFPFGTARQSQQVCTAQPDRLFETDDAPCEDCWQSCLFPSAPPRAWSPGDWLCPQCRQHNFSNRERCFNPRCAAPRPAWLYAYARAGPPAYRRDRDRRVRRFQNDLLGRDRLPTRPPPQPPSISTPNYAESSRMGQLRAAGSRHASRSGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4L7</accession>
    <name>A0A1Y2B4L7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_598575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4L7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4L7"/>
    <dbReference type="OrthoDB" id="2596994at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="480" mass="52719" checksum="246756D627965713" modified="2017-08-30" version="1">MVFDLPINCSLHSNRYLTYYLFQPLTMNSWEGGFRSPSPAGSWSSGDNGGSGSVRYTDLTLDAQLAKDLDLTSRIDRAIHKDNPFTMAKRRATRKPTMKPNIIAEAKKPRGSIKPVVTTTAIVREDNGPRRRATAAADGPTKSWRPHNGWLDGKNNPITMDEKAPSMLEALDEQEKEPLKGGKRKRVGTAPNHSPAKKQEKATKRNKAEEDKIVFTRIPAFAVASKDYPILQGLAKQRSLPKKQKKPAITSRMSTSSDSEADLSIADLIKGSRTRKPANSKPVKTVFEAVRTSSTVQHDGDRLPSGIETLVRHILPRLPSGSKTAVDSGLVSPAGGFDVSDSNDISTITHLPSSVCRELDTSEISSKAPYTSPLQGRDPSLELIRPKPQRVTEAVQLEALAALSDDHAILRYEGTRRLRHPAQSRKEKAPKLRDGCFDSQSAWIDDAADATRARRDTCYSMPRFGGFADCGLYCHDVSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4P4</accession>
    <name>A0A1Y2B4P4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_162614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4P4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4P4"/>
    <dbReference type="InParanoid" id="A0A1Y2B4P4"/>
    <dbReference type="OrthoDB" id="2564065at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="349" mass="38425" checksum="6DB87F43BC2E4348" modified="2017-08-30" version="1">MFHIKRAYLVVIFGLFAQLALSILNVSVLIAVVFRFQPNHAGCDTEGGCGWGTTFTLCAIVILIHLWQASVLTNVVLVINAGGTFSPWYFDNGNLGTRQSLKLAMTRSLGSIAWGSLLVGIIELIHKFFHMMEQALSSNPCTACCCKILSCFTMILKKLIEKFNRYVYIFIAVGRPSLDPPVESFSDDFRAAARHTLQFFGRRGKHDTAIARSQGLASLVDDSIVDLSLTAAAFVTGMLCVGFTYLYMYVVDDKAVSNHSYNWGILIYAFISSHSICLLLTSALDAGVSTIFVCISEDESRLEDKAPDLYQLIVGNARYQAIFPGVARSQPVRKEGSIGQMTDIAKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B509</accession>
    <name>A0A1Y2B509_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein SYM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_531384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B509"/>
    <dbReference type="STRING" id="71784.A0A1Y2B509"/>
    <dbReference type="InParanoid" id="A0A1Y2B509"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="188" mass="20787" checksum="9F6D54C821BC2FA8" modified="2017-08-30" version="1">MAGLLGAYQSFLARRPLFGNMVTSAALFATGDVIAQQGIEKKGKDHDFARTGRIVAWGGGVFAPVVSVWFRVLERVPIKSKWPGAIVRMSLDQFIAAPFVLTGFFTFMTLLEGKDLNAVREKWDASFVPTLKANWSVFLPVQFLNMGLVPLQYRLLVVNAVNIPWNTYLSLQAAKGKNVEPADVVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B564</accession>
    <name>A0A1Y2B564_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cwf18 pre-mRNA splicing factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B564"/>
    <dbReference type="FunCoup" id="A0A1Y2B564">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B564"/>
    <dbReference type="InParanoid" id="A0A1Y2B564"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="177" mass="19806" checksum="890CEAA443FE5DA8" modified="2017-08-30" version="1">METNLAATSAARKERLIALRKRKQAAETGNGANGGPSHFAFKQRNYDPETRQHRKREAGEAGEDTVENAVEGLAEQIIREDEEKRKEELDLFNIQPRRANWDLKRDMTNRMSKLERKTNEAIATIFRQRLQAMRKDAGGGGGEVDILASINAAEHERDEAAEADERAAEADSASDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7J6</accession>
    <name>A0A1Y2B7J6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_528477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7J6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7J6"/>
    <dbReference type="InParanoid" id="A0A1Y2B7J6"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF2">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="612" mass="66649" checksum="7F522546BCBD50F2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B859</accession>
    <name>A0A1Y2B859_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_593552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B859"/>
    <dbReference type="InParanoid" id="A0A1Y2B859"/>
    <dbReference type="OrthoDB" id="2525787at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="166" mass="18570" checksum="2D2B51B7FCF9C05A" modified="2017-08-30" version="1">MIVRYPPALSFSVYLEVQNSIKRRDAVPQSGTKRPEYIAHPAGSLVCRPFGECEPCPHNELDQPFCLPFGNRRLLHCLPADQAHDVLSGYESADDRKQPKGEVPAWEACGKVIVTERRDFYEFVTANLLFLIVALTILWARSSALAAAQYRQLAARIGIPSGSWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8G7</accession>
    <name>A0A1Y2B8G7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_564795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8G7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8G7"/>
    <dbReference type="InParanoid" id="A0A1Y2B8G7"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="213"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="312" mass="34617" checksum="3C55B4337A9438F6" modified="2017-08-30" version="1">MSTTRSMLSSLSYPLRSSVVAVRGVHSTSNALAGAENPRPGDNAPPADPDEDPAKGGSGFLGSIMYGSKKARAEGLVAGDSGSHSRLVGRGKYVHEKITHAIIPSKRAEYLAAAEKYFRTLRERSPELGGVKLTGSWETVVGSVDNFTHIVEYEGYRGYDATLRALRGDSDMVKLETAIFPFVTSRHHQIMSEFSFWPSSPPRDSGYPNGGVFEMRSYQLKPGKLLEWEGAWRRGLEARKRFVVPVGAFFSQVGQLHEVHHIWQYPDMETRKRTREQAWSVGSWSDTVQETVKLADSMKSAILIPTSWSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B995</accession>
    <name>A0A1Y2B995_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_598061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B995"/>
    <dbReference type="InParanoid" id="A0A1Y2B995"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="165" mass="18670" checksum="FC9D0930F2D9F3CE" modified="2017-08-30" version="1">MARRGRAEISSIRTVTAHLLNSDVEQKGDEDSTTFLHEENFNVEKIDSDARLENELVCHAQETTFILIAMLRCASGLFLPLWKVRAQQLVRSNLARFLLRDRRQGVRAEEIRGCLFGSGTRPARFRVPDDPKKLSVVYSYVQVGLLKVRLYDASGDHLTGILVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAB0</accession>
    <name>A0A1Y2BAB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDSL/SGNH-like acyl-esterase family found in Pmr5 and Cas1p-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAB0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAB0"/>
    <dbReference type="InParanoid" id="A0A1Y2BAB0"/>
    <dbReference type="OrthoDB" id="2588793at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52461" checksum="636169B291819800" modified="2017-08-30" version="1">MVGPGSSSSSSKSRASIASIRRFRYLAIASCIACVLLVSGRYSHPETFSALTSFSPSSSFSSSSSSSQQCDPYQSLGYLHVSTFDANAHRWHPFREDCHAPAYLAALVKEAWSIQEPTNSGPLTKPSAWRESDLGPDGREWQDVSWARNKTVVIVGDSVMRFNALYFCKIMGENFVEMKWDHPWSPPSPMLGKPMHGHKRDSTPLSTNSNSDSNDTTTTTIAKSSNAGNPNSHLTHYCHIPSIDLFILQIFHVGLDEDEAWIHKEGATTAYTVEDRIDKLLKVYLQKLEEQEGRSAPVLGYLQSSLWDAARWTQEDAKANAPEDLVLSDERLRWFRRRVREVILHMRRAFPSMALRWMTTHYPVNPSTGRFFDSKRPPSRLDWLSQINAASLSAFRDTDGLDPEEARLLRGVQSNNWGDLMMGQEKHLADDLHPAMFPGGYLWGDMMLWDLKQAVTQRSSLWSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAF7</accession>
    <name>A0A1Y2BAF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_528146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAF7"/>
    <dbReference type="InParanoid" id="A0A1Y2BAF7"/>
    <dbReference type="OrthoDB" id="10394409at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="62884" checksum="A6046D86F3F5A729" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB86</accession>
    <name>A0A1Y2BB86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase/reductase SDR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_526267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB86"/>
    <dbReference type="STRING" id="71784.A0A1Y2BB86"/>
    <dbReference type="InParanoid" id="A0A1Y2BB86"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000439">
        <property type="entry name" value="Short chain dehydrogenase/reductase (AFU_orthologue AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33543" checksum="1F5943FC53B7F1BF" modified="2017-08-30" version="1">MRSPSSMIHQGAVAVITGGASGIGLAAALRYAKSGMSIFLADISEQALSTAVETVKGVSGVGDVLGMKVDVSEVAEVVAMREKVLDTFGEIHILMNNAGTSAPTPAFSLTTSLEDLQTNWHKVLNTNFLGIMNVAQAFAPYMVRQENNSVIICTGSKQGITCPPGNAGYNVSKSAVKTYTEQLAHELRNVGDSNCSAHLFVPGWVHTGLTGAKNGAPKPPGAWTAEQTVEYMIEKVFEEGDFYVICPDNETSSALDKARIQWNLDDILLNRPALSRWDPEYKARFEEFVASKMGLSARSRSRGRQERSPGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB91</accession>
    <name>A0A1Y2BB91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_524114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB91"/>
    <dbReference type="STRING" id="71784.A0A1Y2BB91"/>
    <dbReference type="InParanoid" id="A0A1Y2BB91"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="42902" checksum="97FBA89F45386906" modified="2017-08-30" version="1">MAFFTMFPTSQYNPEVYSPYPFPDQSAHASYPPQDPSIRHTPQPQPPPPPPPSHSYTYHAPHWDPPSPPVDPLLPPVPAVPSNSNNHSQSNYDTSVYHQRVPSPVTVPPLPLHIESAFSPHPAWSNLPQAPNNGFPNVDANENRWQAQHLEECGGTGVNGWGTTLPPLSSLPQMPSVDKGKGVDRGGGDWAEEFGREVKRARQDPSVVDRDVALLQTYLTELVHLMSPFAATPSNPAPPKPPPYLHTHFSRLSALVHSTLTCLVPNIHTTLSPMFTPSPGMVKELTAAEKEMELIRKRRDALIAKAATKSGFDGTASGARASISGISALDESAFSSMGHIVAPGRCHGCGVAATPEWRRGPDGPASLCNSCGLHYAKLAKKREAEAAAAAAEAVINGTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBD6</accession>
    <name>A0A1Y2BBD6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_593290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY32016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBD6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBD6"/>
    <dbReference type="InParanoid" id="A0A1Y2BBD6"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="274" mass="29036" checksum="24194CFF0D212E6F" modified="2017-08-30" version="1">MSDTMTSHGSKQQGIALITGASSGIGRAASGPDTAAIALTSCGWTCILSGRREAELERTAELAAEARNKRYPGDTSRPLCVPGDLTDASNITSLFMTVKTVFGRLDLLFNNAGIGSPKVPLQHLPIESFDQLININIRVPFLCTQEAFRIMTTQSPQGGRIINNGSVSSTTPRPLSAPYTLSKHAISGLTKSTALDGRKYDIACCQIDIGNALSVMSSAKAAGVQQANGNVEEEPTFEVDYAGEAVAYMASLPLHVNVFNQTLMATHMPFVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBR9</accession>
    <name>A0A1Y2BBR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin interacting protein 3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_524639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBR9"/>
    <dbReference type="FunCoup" id="A0A1Y2BBR9">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBR9"/>
    <dbReference type="InParanoid" id="A0A1Y2BBR9"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="3">
        <location>
            <begin position="580"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1063" mass="115640" checksum="6D255A5709207C7A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC29</accession>
    <name>A0A1Y2BC29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_523905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BC29">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BC29"/>
    <dbReference type="InParanoid" id="A0A1Y2BC29"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="6">
        <location>
            <begin position="931"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="7">
        <location>
            <begin position="1767"/>
            <end position="2328"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="8">
        <location>
            <begin position="2859"/>
            <end position="2902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="884"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1201"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1527"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="895"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1532"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2929" mass="326376" checksum="A2312B20CA552E5C" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCF3</accession>
    <name>A0A1Y2BCF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_586847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCF3"/>
    <dbReference type="InParanoid" id="A0A1Y2BCF3"/>
    <dbReference type="OrthoDB" id="2596711at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="721" mass="76306" checksum="58E2E750B5672336" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCU0</accession>
    <name>A0A1Y2BCU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60s ribosomal protein l9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_564253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCU0"/>
    <dbReference type="FunCoup" id="A0A1Y2BCU0">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCU0"/>
    <dbReference type="InParanoid" id="A0A1Y2BCU0"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="112"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="191" mass="21152" checksum="4F3F8A625868CD20" modified="2017-08-30" version="1">MKDISSVESLDIPEGVKVTVKSRKVTVEGPRGSLTKSVGHIQMDIQVVKTPKANKVVFTIWHGARKHVACLRTVKSLVENMIIGVTKGFLYKMRLVYAHFPINAIPSEDGTAVQIRNFLGEKYVRDCPMLEGVTVKMSEVKDELIISGNDIENVSQSAASITDKTRVKDKDIRKFLDGVYTSETTTVVQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCW2</accession>
    <name>A0A1Y2BCW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_464762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCW2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCW2"/>
    <dbReference type="InParanoid" id="A0A1Y2BCW2"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="619" mass="68900" checksum="3D90C497828DB81F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD80</accession>
    <name>A0A1Y2BD80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_521504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD80"/>
    <dbReference type="InParanoid" id="A0A1Y2BD80"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118844" description="DUF7729 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="4">
        <location>
            <begin position="94"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="36748" checksum="ED1FE1390F3AED45" modified="2017-08-30" version="1">MRIPPLPLLLCTMVGGAACSSDIEPPLPLPPEESPTPTPPPTPTLPCSPIFDDIVIFPSPSSRSRRTPRNVTDTIDVTIPSPPTTTPVSLPFPTPTPLDLSISPKLTTNCISYLTNLLSTPLFLSCLPFSLLLTTSTSYATLLATAISTGDYTDLNILLSYVASPQPNTTQCQTYMDSLVGELGNKGQCGSDLAKTPIDPVAEETRVGLGNYKVMREAAGLVSQESGKYCYLEAVSNQTPDDLYLWSVPAGIPLPSTTTPTCSKCSEQLLNLYMLNLASNSTMNATIINNAVNTVNSKCGSAFVTYQAEAVSAAKRRVSVSVYMASTLAGSGCVLGLVVLVAVLSLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDA5</accession>
    <name>A0A1Y2BDA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_521717</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDA5"/>
    <dbReference type="FunCoup" id="A0A1Y2BDA5">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDA5"/>
    <dbReference type="InParanoid" id="A0A1Y2BDA5"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="246" mass="28464" checksum="1D73918EDB17A3D4" modified="2017-08-30" version="1">MFQVSWDLCFIFELNDSGGKMAQVVALLDQPSSYRDNRSELDRETERRLLALSSTLYVGNLSFYTTEAQMYELFSKCARPEYGGGIKRIIMGLDRNQKTPCGFAFVEYYLHTEAVACMRYISGTKLDERVIRCDLDPGYKEGRQFGRGKSGGQVRDEFRQEYDSGRGGWGHQRLEEEQRRQEQDRFKAQFETYASTMGGLGMAGADVPRGEQHEASREKRGRSEDEDDDVDRRDDEKRFRGERDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE21</accession>
    <name>A0A1Y2BE21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_521066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE21"/>
    <dbReference type="FunCoup" id="A0A1Y2BE21">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE21"/>
    <dbReference type="InParanoid" id="A0A1Y2BE21"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="7">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="8">
        <location>
            <begin position="212"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="323" mass="33157" checksum="B528E990D184E8E1" modified="2017-08-30" version="1">MGYTLAVLGCGTMGIAILSGVLTSLETRSQQSNGSNSTSSTAENTSNEPPSGISTPTASQFLDAPDAALPSRFIATVGREETGRKLKKVFGAMGGLGTGVEVRAGKGNVDAVRDADVVLICSKPQIAKLILAEQGMSDAIDGKLVVSICAGVTIAQLESWVPAGTKVVRAMPNTPCKIREGMTVVTPLSDPLSRALILAIFTSCGRCRFLDEKHFDACTAVAGSGPAFVALVLEAMADGGVMMGLPRAEALELAAQTMQGAARMALYAGLHPAQLKDSVTTPGGCTIAGLLTLEDGRVRSTMARAIQVATNHAAGLGQDPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF09</accession>
    <name>A0A1Y2BF09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH dehydrogenase 1 beta subcomplex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_557052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF09"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF09"/>
    <dbReference type="InParanoid" id="A0A1Y2BF09"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY33364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="66" mass="7548" checksum="38421C67868C15C5" modified="2017-08-30" version="1">MPGPLYRDPWAKREAWRSHYIFSSRNYLRHGLPGFGIASVAFAAYVIYDDFFASKPTHSAGHGEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFT5</accession>
    <name>A0A1Y2BFT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_586489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFT5"/>
    <dbReference type="InParanoid" id="A0A1Y2BFT5"/>
    <dbReference type="OrthoDB" id="2585179at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="105" mass="11398" checksum="732A6CD0C3C08CF1" modified="2017-08-30" version="1">MTTTQPAKPLHLDPENTYIQITTSPTHDPTALNISGPSRLQYLGPVGELKGEHIFQLQTSDGAPVKRATIEAGEAELGKRAVEAVRAVQGVKGAKIMEFKHRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG10</accession>
    <name>A0A1Y2BG10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_519029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG10"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG10"/>
    <dbReference type="InParanoid" id="A0A1Y2BG10"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="308" mass="34154" checksum="99E276A227408048" modified="2017-08-30" version="1">MVNKHVVITGASGLLGRAVVEKFRQGGDEVSALAWSRADKDTSYTKLDLMDTASVDKFFEQHEVDVVVHCAAERRPDVAEADPAKAAKINSAVPAHLAELARKYKFTLIFISTDYVFNGRNPPYEVDAAPDPLQAYGHQKRDGEIAVLDQRSKGAKATVLRVPVLYGKTEYNAESAVNLLRDVVQDQSGKQYKMDAYQKRYPTNVLDVGRVLFDLAHIDKPLPAILHYTSPAPAMTKYDMCTIIAKYLHLPINHIMPQTEKPTGPGTTERPEDCTLSTTALSDFGIDTREDQVFEQWWSKEIGSGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG73</accession>
    <name>A0A1Y2BG73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_579484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BG73">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BG73"/>
    <dbReference type="InParanoid" id="A0A1Y2BG73"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="635"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1370"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2009" mass="223326" checksum="DA678AF9DE958911" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGA7</accession>
    <name>A0A1Y2BGA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_564065</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGA7"/>
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        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGA7"/>
    <dbReference type="InParanoid" id="A0A1Y2BGA7"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
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    </dbReference>
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        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
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        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="15">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="316"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="129"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY33115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="587" mass="64401" checksum="2511EC04BDBE088E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH40</accession>
    <name>A0A1Y2BH40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_299834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH40"/>
    <dbReference type="STRING" id="71784.A0A1Y2BH40"/>
    <dbReference type="InParanoid" id="A0A1Y2BH40"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="204"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="309" mass="32723" checksum="B2FA9FEDA92213B9" modified="2017-08-30" version="1">MSALPRTMKGVVLSAPYEISVQDQPVPSIQEEGDVIVRVHVAGLCGSDLHFYRGTEMTEFSPFIMGHEAVGEVVEVGSGVTKWHKGDIVISPFSLSCGDCFYCKRNYTARCTSATLLGSPTYPGAQAEYLRVAMADASLFAMPPDLPKELGLMLADILPTGYSTAYNARRLADEEESPVSVGVEKTSSDPLVKKGVCVVVGCGPVGLCAITSATTMFEKVFATDLQTHRLQSAKKHGAIALPLDQLRPALLEATGNRGADAALELVGHEGALITAIDLVRPYGVISVGGVHSKPVNISGDDLYGKKAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHE8</accession>
    <name>A0A1Y2BHE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_516789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHE8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHE8"/>
    <dbReference type="InParanoid" id="A0A1Y2BHE8"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37311" checksum="0724A1952224361D" modified="2017-08-30" version="1">MGEKTTDFDSLHFDPDDLKPPSWAAGPQFQWAHDKPGEGSKAASSGFKDREPTPLDLSDDEDEEDEEDQVFEDARDDMGADEVEEINGMVTFTVPEMRVLLSKAISFKETGNAAFTTKPPNLDLAIESYQSALKCLPEVPKLAESQPPREPTREAGSGIEEVTDEEAKQIERDEEARRMGEQPDERKDLEADIRECAKACWGNLAACWIAKNDDAEAVKACTEALKLDPTYVKAIQRRASANDRISTWSSLSSARDDYNLLLTLLPPTSTQIPIIRRSLASLTPRLKLQEDKEKDEMMSKLKDLGNSLLGNFGLSTNNFKFDPQPGGGYSMRFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHK5</accession>
    <name>A0A1Y2BHK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Pex12 amino terminal region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_518104</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHK5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHK5"/>
    <dbReference type="InParanoid" id="A0A1Y2BHK5"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="34"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY34007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="422" mass="47151" checksum="A0324C0FEB78DFE1" modified="2017-08-30" version="1">MAVHDFGINAEASSSRNRLPSAPRVSQVDADELDEGLVSMLGERVEKALGNFQSSLGHDIKPEIALVLKLVVFRFSILDPSTRASPGAKLQNLKLAATRSSRRIWLLYLLLHPPIFPSYLLTRLRQHALSSQWPDLPAHDWRRKAWKAVIRAETAAKAWELAGWGWFLWDGRYPSLLMRLLGLRLVPASPHLARLVSYEFMNRQLVWGAFTEFLMFAIPFLPPIPNFLTPSSLFSPIKNLLKHPTPIDYNALITLPRSSDSSKTPTSTLAHSGPLAKLPRSTCPICYLRHSSDPIPLDASTSQGASINLPPISQHESDEETKDETRIYVPAQTDCWGGCRWCYYCIAGELAKHHDKVKEIKLGSKSEEMEKWSCLRCGGGVSRAWRVGPAASMDNETSRVDKETPSIGNELPSIEKRKAQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIX9</accession>
    <name>A0A1Y2BIX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_514314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIX9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIX9"/>
    <dbReference type="InParanoid" id="A0A1Y2BIX9"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF55">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="324" mass="36323" checksum="A3B97090DE6F2323" modified="2017-08-30" version="1">MSAVPSFTDTAALSERRLRDPQRGPEESKKRVLVTGGSGKLGRWVVREMVDHGYEVFNLDMIPPAPSEVDVKARFILVDLRDYGQVVSTIMDVDSGYKGVDAIIHLAAIPAPAKAPNHVVFHNNSLQTYNILEASRVTGVKHVALASSETVFGLPLYPHSPTKLPVTEEVERPESSYSLAKLMGEKMSEQYCRWDPKTKIINIRLSNVMSPDDYARFESWQDDPWERAWNGFCYIDARDCAQAFRLAIESSLTGFHVFNIANADIAYRKQTTAQLAKLVFPEVPYTPETDNPREGLISIKKAKEVLGFKPTHDWQSEAAKLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ77</accession>
    <name>A0A1Y2BJ77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_515103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ77"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ77">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ77"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ77"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="54"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="918" mass="98648" checksum="0F130E405547304F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ97</accession>
    <name>A0A1Y2BJ97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_513938</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ97"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ97">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ97"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ97"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="162"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="484"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="725"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="762" mass="83777" checksum="5A4333E522313546" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ98</accession>
    <name>A0A1Y2BJ98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_133709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ98"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ98"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ98"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="398" mass="43484" checksum="FC246EB0FFCA30A6" modified="2017-08-30" version="1">MSNPEARRHKLSHPAKLKGKESPEGPVPSARSSSLIHTRRSSLPPTASNQSPSSSPRSNIVPDPSATYQSASFASKSLIELRASVPAQSPTLSFRTLPPVQRRALNPGTASTLSDYSLHGTSTGHEFTEQVDETQLAILYTQLQSREAKRRYRQSLVDIQDDWVFQREARNLVKLESTDVAEWQGRRAGSGDSVGAWFVTRELVQGERRHGRILSKGVEMVRAAAAAARVRDDVPTASRIESSVSKSSIRLRRQRTAPGSSRAKSEQRHETSRSEETAVIPLDILLFRLPRLLALSLTLSTRFDHDPSPAGVATAFSEMESNLTSEIGLWAGEIGSIVTTGLGRTIGKSMQSGGADKNDPRGEDRDDRLILGDIADYNADTKSSKVQTSLPRNDRPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJG1</accession>
    <name>A0A1Y2BJG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_515573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJG1"/>
    <dbReference type="FunCoup" id="A0A1Y2BJG1">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJG1"/>
    <dbReference type="InParanoid" id="A0A1Y2BJG1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="88"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="594" mass="63789" checksum="BB15EB1CCCABED55" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJG8</accession>
    <name>A0A1Y2BJG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_137457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJG8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJG8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="76" mass="8556" checksum="3114E0CD9F5F4E03" modified="2017-08-30" version="1">MMNYIIILLTKKSMQNLYINYPTRSPVPFEYPSDRINPDTTSFKSPSSINGNTISPSLTPSTSRYLSPNQARGIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJM0</accession>
    <name>A0A1Y2BJM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_140063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJM0"/>
    <dbReference type="InParanoid" id="A0A1Y2BJM0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="68" mass="7813" checksum="48949DC1967A776E" modified="2017-08-30" version="1">MFPRQSYPSALCICYSALFSCQISSTEGNVWRGHKENKLGYLEVWLNISWENVLDLSAVVFVENLQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJQ7</accession>
    <name>A0A1Y2BJQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_515990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJQ7"/>
    <dbReference type="FunCoup" id="A0A1Y2BJQ7">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2BJQ7"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="516" mass="56566" checksum="DCCAB07CBF89EA86" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJR4</accession>
    <name>A0A1Y2BJR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-induced vulval development antagonist-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_515174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJR4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJR4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJR4"/>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="4">
        <location>
            <begin position="387"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="494" mass="57201" checksum="F9662FD1B6825623" modified="2017-08-30" version="1">MATVHPSRLRLVPQAPPARPPSPVSREEALRRQLLERRGRRESNGDSRDAKRVKEYEDDREADKRRATRRSRSRSRDDRDGSRRRDRSSDRRDGARHSRRSPSDEDHRAVPLKDARSPRRDDRNYRPHRDARSPRQDDRFRRPSPSYKTYSGPPPPREESFIPLNGANGPGPDLSRYGYGGDRSDLGPPRGPPPIRGGYQGGPARVGFGGVANFEERRQRREASTVSVWPPSPKEPYKDEEELDAERKARRKADRSSKRLKRSKRHTRRYSDESSSETDSEEEERRRRRRRKEKERRARARDSDEDNSEAEERRRRRKSRTKSRTKEVEDVMEEEMWVERNDRATSSPLGSAPATKKVGEEVDDGPEVGPQLPNDLSLRDRKDRTAYSHMLKGEGEAIAAFVESGERIPRRGEIGLDSTTIDAFEQAGYVMSGNRHKRMNAVRMRKENQVINAEEKRAILKLQREEKEKKEGAILMGFKEMMDESLRKQGLNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJR8</accession>
    <name>A0A1Y2BJR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1168-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJR8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJR8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJR8"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25229" checksum="EC16F07CE6AB7289" modified="2017-08-30" version="1" fragment="single">MPYVKDDSESPRRRHLSLSPDPKDAPGPSAKKTKLSTVDHMRRQVDKLFEHPEKEVQLPTGPQERTLRAPQEMMKNVPGSSAGAGSGEFHVYKQARRREYERLRIMSNQQRALDEQAAFKARQAERDAAAEAKTAKNRAKRQKRKQGKGPGAAKLEGKDAPVGETKRKLGGGGGGAVVFRKPGEESDSESDDEAQEVGPAIDSSASVPVQSEEVQAPRIVDEANIIIRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKZ4</accession>
    <name>A0A1Y2BKZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_509720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKZ4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKZ4"/>
    <dbReference type="InParanoid" id="A0A1Y2BKZ4"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="157" mass="17604" checksum="8A929CC3DAA855CA" modified="2017-08-30" version="1">MATGLASKRLMKELAEIKSKGTPPGITLLSAEDMQVWLFSIQVLGDETIYKGETFALKMKFGPRYPIECPEVTFVADQTYNAVIPIHPHCYSNGHICASILGNEWSPVLNCVAICITMQSMLASNKKKERPQGNDRYVRNAPSNPKLTRWHYDDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLA3</accession>
    <name>A0A1Y2BLA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_510606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLA3"/>
    <dbReference type="FunCoup" id="A0A1Y2BLA3">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLA3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLA3"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY35543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="329" mass="38133" checksum="7C035E36B9D0BB6E" modified="2017-08-30" version="1">MSTSYIPLSQRGTWTGIEPIAQDDGPNPLCAIMYANEYRDAMDYFRAIRASGEQSERVLELTETIIRDNPAHYTVWQYRLATLLALGKDLKEELELMNEFARINLKSYQVWHHRLLLLTHISPAHPRAEIDFIHDSLIPDSKNYHTWAYLHWLYSHFSTLGRITEQDWGEEIRWCEELLRVDGRNNSAWGWRWFLMVSRPGAEGSKDGGEEEISYTLKAIHRIPHNVSAWNYLRGLLKHLNQPFTPLLPAIQTYTGHGSTPVKDFSYPIPLDPLSRDTPLPISHALEFLADALAEQGKTEEAAEVFKQLGQEVDRMRAGYWDYRKQQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLD2</accession>
    <name>A0A1Y2BLD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_21276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLD2"/>
    <dbReference type="FunCoup" id="A0A1Y2BLD2">
        <property type="interactions" value="795"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLD2"/>
    <dbReference type="InParanoid" id="A0A1Y2BLD2"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="304"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="426" mass="46902" checksum="A6DD177B7BC8AA88" modified="2017-08-30" version="1">MSGSLTHVLFEGSSGYALFTVSMQEEIAAKSKQLQDAITDYNTFSRMVQLASFLPFTSAAQALENANDVSEGILNPHLRNLLNIIVPGDKGKSNKKASGVLLGVSERGLGGAIMSELGIPCDTGERALELIRGVRLHQEKMLVKGGMHKGDVFVAQLGLGHSYSRGKVKFNVNRSDNMIIQAISLSDQLDKDLNTFSMRCREWYGWHFPELYKLVPDAHQYAQLAVLIGDRANLQESALEDMQEILDDDETRARNVLDAARASMGSDISEIDLINISNFAERVVRLAEYRKSLRNYLVEKMNVVAPNLSALIGETIAARLISHAGSLTNLAKYPASTVQILGAEKALFRALKTKGNTPKYGLIFHSTFIGRAGAKHKGRISRFLANKCSIACRIDCFSDVPTKKFGEALRAQVEERLNFFEVCGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLU7</accession>
    <name>A0A1Y2BLU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Chitin synthase</fullName>
            <ecNumber evidence="2 12">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_510658</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 12"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLU7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLU7"/>
    <dbReference type="InParanoid" id="A0A1Y2BLU7"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY35547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="709" mass="79400" checksum="EA08B75DA515E3BB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMD6</accession>
    <name>A0A1Y2BMD6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_513195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMD6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMD6"/>
    <dbReference type="InParanoid" id="A0A1Y2BMD6"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="348"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="469" mass="53439" checksum="DC8FDDBF8565438B" modified="2017-08-30" version="1">MTGFSNPILPGFNPDPTIVCRGDNYFLATSTFEYFPGVPIYTSIDLVDWQLIGHALNRRSQLDMRTAEAAAGIYAPTLRYNERRERWYMTTACVFKNAKKADHDSPPPPRGFYVWTDNIWDETKWSDPVYYDVAGIDQDLFFDDDGKVWLSWATTIPDHIDQPGHFSLTVWTVQIDLDTGDNIGQPKLIRQNTTFGNRVAEGPHIFKKDGVYYLITAEGGTEIEHSEWICRSTDGPRGPWEVGPQSTVNPMVYNGLDYDVMQTGHMDMVEGKDGQWWAVCLAVRPQRGILSHLGRETFLAPVEWKDGWPVVNAGRKIGLTGPEDSGLRRIRNQQSWKTKFNKDLDLYKNGWYHCRTPIKPYHGLSSAGLILKCGQYALQHDEAVSMLLKKQTAFVGTWHIEFEFEPTWPGEEAGVTVWWSKWAHCSVSIRGKRGTACWPEGQYGAELVFRKPKEEGNDFEVGRLLHCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BML2</accession>
    <name>A0A1Y2BML2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_502706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BML2"/>
    <dbReference type="InParanoid" id="A0A1Y2BML2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="175" mass="18840" checksum="039E01764157ED9E" modified="2017-08-30" version="1">MATIRSATTTANTAAVSNKLASSTTSNAPTDTSTYNFLVTDPTDSITLKFGVLITAGTTVSPDVAAQTASKVERKYVGRNGSVLPKQAREAWKVRDRGSASASYQYTFRSNLEKELDIPSGDGNTYADFGPDRMTWLHPRIDVTQESFQGNIVWGQTEVKDSTGCFSGFSDCSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMN4</accession>
    <name>A0A1Y2BMN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_596451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMN4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMN4"/>
    <dbReference type="InParanoid" id="A0A1Y2BMN4"/>
    <dbReference type="OrthoDB" id="3005035at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="378" mass="42691" checksum="887A02EAD8240FFC" modified="2017-08-30" version="1">MSLEHRPTSLTFPTPSNGPQLSDTSSRSPRLPSSPVLLHPLPPSQALQRESLAQSELELDRQTRQRQRERELAEALQEQQWEIQRATARDEIGTSTIRRTADKDKDKGKGKDVNKESRGFTRPPQAYELYQAIDKHDIDFIMRVRDHAFGLLLAKNAGEFPIVYAARIGESHRDIVILLVGALSRYVNHLEDEDFEKKETRNILKALRSNLKLAIDNALLPSHSTHLLSSYLQVLIMSEGDAWLHKATYDVSLLVRAPDEKPVASAEEMVRRFCTKELRGAGGVEEYITNAALDLVIMAVWSVAAQQMGADPLPTHTFARDTRTYSMLKEAMEENKGKLVKVSPRIRRFLDVLLERAGDTKKSIPGRLRDVQEVLDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEL4</accession>
    <name>A0A1Y2AEL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_554891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000127">
        <property type="protein sequence ID" value="ORY20707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEL4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEL4"/>
    <dbReference type="InParanoid" id="A0A1Y2AEL4"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="378"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY20707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="876" mass="95534" checksum="9ACFE2ACFAD2C64F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF14</accession>
    <name>A0A1Y2AF14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_562747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000117">
        <property type="protein sequence ID" value="ORY21161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF14"/>
    <dbReference type="InParanoid" id="A0A1Y2AF14"/>
    <dbReference type="OrthoDB" id="2564008at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="269" mass="30190" checksum="3F98CC36D0AE8864" modified="2017-08-30" version="1">MFRSKKRPESITSGRPSSTTSPRSPSVTGSSGPGNSPRSHHVSATVPMSERRQPQQHIGLSRLLEVYDEYPNVVAELESTISQLHLAEESQRNANLKRFEVEEELVKEKEGRAKDAENAEKAKVAALALFKEEKEKAEQAMDKKVRGELDPKIKALEEKLKTTETEREKWKSESEVRRKKMEGWIESMEKLNKERNDADAREIKAAEERKVVDVKLRELDKTILDGLKEATKPTEETIATKSTATTTAAKSASDPTPPPPFSATPRKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFR8</accession>
    <name>A0A1Y2AFR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_553517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFR8"/>
    <dbReference type="FunCoup" id="A0A1Y2AFR8">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFR8"/>
    <dbReference type="InParanoid" id="A0A1Y2AFR8"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="232"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="417"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="810"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="734"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="861"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY21458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="912" mass="100726" checksum="7E4ED9699D46FA56" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG03</accession>
    <name>A0A1Y2AG03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG03"/>
    <dbReference type="InParanoid" id="A0A1Y2AG03"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="324" mass="36115" checksum="A9EB7825945C8043" modified="2017-08-30" version="1">MSSEHEHSTESEREHSTESDGSHGTESDVLHGTETVQSTSNLDHFSRLPPELIQMVTQQSVDDMAMSGWGVLKRAKWLASLRRTSKKTNYALLGPTSLGSEMWPIFTLPTTDDSASKARFAQCLRFVSNPNVTMENLTIPHGIGEVKYLQLELSSEQEDELVFDALARQKDRLKIRSVCVDLKSYTGAERPEVFESVIEFLNHLNSADEVCYSNTPIGFSDNLFSFMPTLASTTVICSSNDEMPSDGSEVRPLKFVEGWLNTHGLELPSFTLALPREYSNDSVKTIKGRMIEMAAQVCAHDNISLPEGTSLAEILQCTNDWTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG26</accession>
    <name>A0A1Y2AG26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_553512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG26"/>
    <dbReference type="STRING" id="71784.A0A1Y2AG26"/>
    <dbReference type="InParanoid" id="A0A1Y2AG26"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY21529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="208" mass="23639" checksum="932EB402307D8BFB" modified="2017-08-30" version="1">MSISDLLAAYAHRRSHYLIGPQCPISHAELEDVVYASLRHVPSMFNMQSTRIIILYDIHHKALWDLCEESLSAEIRARVPNVASEHFPTVQDKIDRLREGYGTILFFEDEEVIRSCSERYPAYTKAFPTWSLQSAAIAQYAIWLALDISGLGLTLQHYQPSLAAIREKWGVPESWTMTGQMPFGSLAGLPVEKNFKHRVEIMTVFGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG70</accession>
    <name>A0A1Y2AG70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_554066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000116">
        <property type="protein sequence ID" value="ORY21217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG70"/>
    <dbReference type="InParanoid" id="A0A1Y2AG70"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="256"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY21217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="466" mass="48877" checksum="1E35DC982C74CD0A" modified="2017-08-30" version="1">MATSTATASAIELQPRNTSNDPASLETNAVSGALPLDGDHARASIIADSTVPDGGYGWVVIFSCAVITWWFVGTTYSWGILQASLVEAGLSSSSTLSFVGSLTVTCIAVLAIVNARVIRALGARYTGVLGILLLGLGEVLGGFCTHNVGGLFVTVGIIMGIGSSLCFMTVSVTPAQYFSKKRGLANGIVYAGGGLGGTVISFAMDGLIQRLGPAWTFRVIGMITLATGLPAAWLIKERAPIRSTAFLDFTLFRDFKFLILFLAGAVATFPIFVPPFFLPLYAGSLQLSSSAGAGLVAGFNFSSAVGRLGCGFMSDRLGPLNTLFISLLLSAASMLVLWPVSTTIAPLIAFVIINGAANGGFFATMPTVVGNVFGSTRISVAMGMIVTGWAGGYLMGAPIAGYLLKAYGGDGSLTNYHPRHVLCWIHDTRRDRIGGNGTNYARQEDLQEVLSDQRYEASDGRVRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGR5</accession>
    <name>A0A1Y2AGR5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative microtubule motor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_553783</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000112">
        <property type="protein sequence ID" value="ORY21377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGR5"/>
    <dbReference type="FunCoup" id="A0A1Y2AGR5">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AGR5"/>
    <dbReference type="InParanoid" id="A0A1Y2AGR5"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="82"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1083"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="533"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY21377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1156" mass="124880" checksum="0312EBFA39100F09" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHV5</accession>
    <name>A0A1Y2AHV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000103">
        <property type="protein sequence ID" value="ORY21860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHV5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHV5"/>
    <dbReference type="InParanoid" id="A0A1Y2AHV5"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="434" mass="47653" checksum="02328A2FFAF506CF" modified="2017-08-30" version="1">MSSQPLLPSSGNGNGESSAVPSFVRRHRLSSILIPLLLIAGVLLVAIRGERVPKDSLGLAKYYLKTSPVIDGHIDLPELARMVYGNNVDKMNLRKKTPGHVDIPRIREGFLGGFFWSIFVMCPESEENDDFMTPTNSVRDTLEQIDVSLNLIDKYSDTFAHCRTADDVMRAVASGKVASIFGLEGGHSLGNSIGALRMFHQLGIRYMTLTHSCNNAFADSGGIFTPVEEKWGGLSPLGHDLIKEMNRIGILVDISHVSEKTALQALATTRAPVILSHSCARHLGNISRNVPDKVLDKIGRDKHKIDGVVMVNFFPAFAAPGEEKLVDVKYIADHITYISDRIGKHHVGIGSDYDGIESVPKGLEDVSKYPYLFAELIERGWTESELSLLSGGNILRVMRGMEAVSAKMAKEGQRPSYAVYDKRHDLDGGFPIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI05</accession>
    <name>A0A1Y2AI05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative oligoxyloglucan-reducing end-specific xyloglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_388615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000096">
        <property type="protein sequence ID" value="ORY22233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI05"/>
    <dbReference type="STRING" id="71784.A0A1Y2AI05"/>
    <dbReference type="InParanoid" id="A0A1Y2AI05"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002860">
        <property type="entry name" value="BNR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052025">
        <property type="entry name" value="Xyloglucanase_GH74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739:SF2">
        <property type="entry name" value="OLIGOXYLOGLUCAN-REDUCING END-SPECIFIC XYLOGLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739">
        <property type="entry name" value="XYLOGLUCANASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02012">
        <property type="entry name" value="BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012146746" evidence="7">
        <location>
            <begin position="19"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="810" mass="87287" checksum="5804E10031F13897" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIH9</accession>
    <name>A0A1Y2AIH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIH9"/>
    <dbReference type="InParanoid" id="A0A1Y2AIH9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="327" mass="35619" checksum="4B00F67A9EDAE8DD" modified="2017-08-30" version="1">MPPISLFSKIQSAFRRTSQSTRYSPASGPDAGSSTGHTARTTIPSASTRTDIGITEPGSFATRDISSVNPSSSTAVRASSFEANGDSNRFSLTTDRDPTPNLTKADEGLGPIQDYSAANRILTLNDLLSRSEQEGPLQKTQDGLSLEYVPHLMRVTQKISRLPFRKRKTTLTLDIDYVPNSDSKSNRYETQLPPERLHGSLPEPVRSTQQCLREPLPDLSFSLFREALLHGLIYPEPSEFNIGEHSHMRVRPTRVGGEGAVYSGTKVPSTGSAAISAAQSSKILSDISHETSSDKGDFAWEDDKVRVQENVLSCSIFIHVGTPIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJL9</accession>
    <name>A0A1Y2AJL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJL9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJL9"/>
    <dbReference type="InParanoid" id="A0A1Y2AJL9"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33599" checksum="80E0A78EEF33FC3D" modified="2017-08-30" version="1">MSLKRKSGTLTHSASPKPSIGIGAGVKAESLDSKRPRTDASGLGPTRILSSTHGRFQHVDTAALELRDRLKSDGTINLELAVFQITELSPHLDASAVIERFKKLEKVDFNPVNGVFTYIYDQQYSTLPDIRTALRTKSTLTSGVEYSSFRSSLAPGAQILVDQLEREGQILIMRSLKGQYMDAPLPPLGRANMLGLRITDHGAAGIGSRWRSIWWDDTRERGRAGQRVDEDFVAAWADVPIAEADDVERLLAAEDLSASSTAPPPVKINAGPAIKKKKRSNRPLKITNTHMKQQGIDFSKDYEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKF4</accession>
    <name>A0A1Y2AKF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_501232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
        <property type="protein sequence ID" value="ORY22962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKF4"/>
    <dbReference type="FunCoup" id="A0A1Y2AKF4">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKF4"/>
    <dbReference type="InParanoid" id="A0A1Y2AKF4"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000077">
        <property type="entry name" value="HemK methyltransferase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="7">
        <location>
            <begin position="45"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="220" mass="23767" checksum="DE5ABFDC91E90420" modified="2017-08-30" version="1">MLPTPQIAHLSAEDYEHVYEPAEDSFILLDALESDLTELVAAAPSLCVEVGSGSGVVSAFIATILNQSSLFLCTDINPWACSATKRTAKANNVNCVVVLDVIQTDLLSPLERRGKGCIDLLVFNPPYVPTDINEASIGDISAAWAGGHDGMLTTERLILKLPNLLAPGGRFYLVAVQQNQPNEILALMRRLGLEANIHLRRRAGGEVLFVIKCYKPNASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL15</accession>
    <name>A0A1Y2AL15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_549528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL15"/>
    <dbReference type="STRING" id="71784.A0A1Y2AL15"/>
    <dbReference type="InParanoid" id="A0A1Y2AL15"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="462"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="743" mass="83269" checksum="94A679410DB64CAB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL18</accession>
    <name>A0A1Y2AL18_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_549624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL18"/>
    <dbReference type="InParanoid" id="A0A1Y2AL18"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY23268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="57" mass="6493" checksum="38BE58FECF2750F9" modified="2017-08-30" version="1">MSCFLHYFITIYIGFNCGLFLFPSPSCPLPPPHTYTHTPSPLLTHTRIHLYTTVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALB5</accession>
    <name>A0A1Y2ALB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_600833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y2ALB5">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALB5"/>
    <dbReference type="InParanoid" id="A0A1Y2ALB5"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000049">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.14, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000151">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.14, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="361" mass="38154" checksum="856928D1A5633EB3" modified="2017-08-30" version="1">MVNNTAYYKTLGISKDATEADIKKAYRKESLKWHPDKNPGEKRAAAEERFKKVGEAYEVLSDPQKRELYDQLGEEGLKGGGGGPPGGGFGGGFPGGGGGGTSFQYSATDPNDIFNAFFGGGGGGAEEMFGGMGGGRGGPRMRSSRMGGGMPGMGGMGGGMPGGFGGQESPGGAAPPPPGEIVKPLALTLEELYKGGTKRLKITRHMRNGTSEEKILEVAYKAGWKKGTKIKFAGAGNEDEYGQSQTVVFVVEEKPHPRFERVDDDLIVKLNITLSQALLGPDGGGSITKEVDQLDGRRIPVTLPEGQIIQPGQETRISGEGMPVSKAGSAKRKGDLIVRWNVIFPSRLTPAQKQELRKVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN53</accession>
    <name>A0A1Y2AN53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="11">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="primary">PSD2</name>
        <name evidence="15" type="ORF">BCR39DRAFT_548143</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="11">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endosome membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="11"/>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN53"/>
    <dbReference type="FunCoup" id="A0A1Y2AN53">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AN53"/>
    <dbReference type="InParanoid" id="A0A1Y2AN53"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="1 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10 11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023246708" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="11">
        <location>
            <begin position="1"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023246707" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="11">
        <location>
            <begin position="1194"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="100"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="490"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="730"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="788"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1234"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1246"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="1049"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="1107"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="1194"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="11">
        <location>
            <position position="1194"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="11">
        <location>
            <begin position="1193"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="11">
        <location>
            <position position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY24008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1271" mass="139810" checksum="7D6659C1567AEA01" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANE8</accession>
    <name>A0A1Y2ANE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_548626</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANE8"/>
    <dbReference type="FunCoup" id="A0A1Y2ANE8">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANE8"/>
    <dbReference type="InParanoid" id="A0A1Y2ANE8"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="26"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY23820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="357" mass="37703" checksum="B16DA4072B765A9D" modified="2017-08-30" version="1">MSTPLVLCMGNPLLDIQVDSSEGPKYLEKYDLKSNDAILAEEKHMPIYDDIVKNAKVDYVAGGAGQNTARGAAYVLPEKSVAYIGSVGDDDLMKTLRAANEAESVISAYQVQPAPARTGACAVILSGHDRSLCTTLRAAELFTASHLAQPEVANIIAGAKYFYIEGYFLTHGVESCLELAKTASSRGKTVVLNLSAPFIPQFFKVQLEELLPHVDILIGNESEAAAYAEAAGMEKDTPLAQVATNLAAASKSNASRPRLVIVTQGASSTLVASSSPSVSPSNLKLEDENPKTYPVPKLAADKIVDTNGAGDMFAGGFLGALALGKDLDECIEVGHKLGQMCCGQIGPKLVFPKEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANI2</accession>
    <name>A0A1Y2ANI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_547657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANI2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANI2"/>
    <dbReference type="InParanoid" id="A0A1Y2ANI2"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY24119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46813" checksum="7F9DFB6FCA4B1BBD" modified="2017-08-30" version="1">MGSNDPPERRLRIAILGGGIAGATAAIALSQLPHVHVDVFDQASALREIGASIALQPCALRCLEKLGLGEEVEKLAWRYGEHPLVHRHWKTAKVIPTPLPDPLPEFRHQLARFYRVHLHQLLLSRIPASSIHLGKRVADVQVLETDEVRVVFEDGSDWAGNAVVGADGIRSRTRQVFYPDYQLGLGGLVTLRQVYETKLLRGIEGIPSESCHWIGPDRQLFTSPLKGDLFSLVAFLPTNVLAPSDQATSTSRSWGTTTSVSNLANYYADWHPTIAAITRSAPSINLYPDYHGPPLASLSVGEDHVVLIGDAGHPHGGAFAAGGSLAIEDAYTLYLCLKDGRSVQDAWSLFDQVRKEHVHRLLRMAEKLRKQRKDDEGKYLNDDEIRQRVEGRGDVTWLAENDVEQVVEKAKEARHEAREKNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APE8</accession>
    <name>A0A1Y2APE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_472413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APE8"/>
    <dbReference type="FunCoup" id="A0A1Y2APE8">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2APE8"/>
    <dbReference type="InParanoid" id="A0A1Y2APE8"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7638" checksum="A427D47418A45694" modified="2017-08-30" version="1">MAFTCSDIFKIILAIFLPPLGVFLERGCNVDFLINIVSTNQLLGYIPGIIHALYIVCLSPLSVFPYDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQC8</accession>
    <name>A0A1Y2AQC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_545942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQC8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQC8"/>
    <dbReference type="InParanoid" id="A0A1Y2AQC8"/>
    <dbReference type="OrthoDB" id="2503643at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="83" mass="8621" checksum="AF27265B34A7E679" modified="2017-08-30" version="1">MSESYASIKALHSSLPSFTPPISTSVLPYIALFALLAFFALAFTFTTLPKSRNPIPELGLALLASALAGGGVVALFCTVGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQI3</accession>
    <name>A0A1Y2AQI3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamB/YcsF family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_546465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQI3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQI3"/>
    <dbReference type="InParanoid" id="A0A1Y2AQI3"/>
    <dbReference type="OrthoDB" id="5295431at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003814">
        <property type="entry name" value="PRK05406.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27639" checksum="C7C492B85AF0BFAD" modified="2017-08-30" version="1">MVHISPPRIEINCDMGEAFGPYPGGPDEEIMPFIDTANVACGGHSGDPVTMLKTVQLAKKHGVRVGAHPGYPDLLGFGRRSWEMSETELYCMILTQVGALKAVAESEGLSLNHIKPHGRLYTTIASERDLCRPVYKACKTFNVPVYGLPGSFHESVAAELGIDFIPEVYVDANYVSAYTLINKLDKTIPPLQRGDLYTKVKQMRDDDSVIAVSGRTVPMGIKSRPFTICIHSDIPDAIHNVSALQDAVKELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR10</accession>
    <name>A0A1Y2AR10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_545514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR10"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR10"/>
    <dbReference type="InParanoid" id="A0A1Y2AR10"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="218" mass="24103" checksum="DBF041F51AF308BE" modified="2017-08-30" version="1">MEAGVMGVGGVQYRNLLHVSREIPPDVKPRLSTSRSMSFAPFSEPSRNIQHSVPPYSPHEQNDYTAHVNRPFRENPFQEPPPPPPHSRSQSFSTVQSSSRTGIIHPPPARYDMPSGSETRHRTRQAISCFPCRQKKLRCDGAKPCVQCVRRNSIEKCAYADGVRRRGKGRRAEDGEGGSSDSGSGGGERDKTEVMDMAEDKLVVLEDSSSVKEEVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARL0</accession>
    <name>A0A1Y2ARL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prenylcysteine lyase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_545021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARL0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARL0"/>
    <dbReference type="InParanoid" id="A0A1Y2ARL0"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="190"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="559" mass="61763" checksum="CF3DB3818E2FACDC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARW8</accession>
    <name>A0A1Y2ARW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_471453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARW8"/>
    <dbReference type="FunCoup" id="A0A1Y2ARW8">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARW8"/>
    <dbReference type="InParanoid" id="A0A1Y2ARW8"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000345">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000004">
        <property type="entry name" value="Putative ATPase, AAA family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY25329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="595" mass="64805" checksum="05C327722EDC7329" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARZ1</accession>
    <name>A0A1Y2ARZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_544529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARZ1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARZ1"/>
    <dbReference type="InParanoid" id="A0A1Y2ARZ1"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="754"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1057"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1116" mass="120232" checksum="4A59C409B1C7A359" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASQ0</accession>
    <name>A0A1Y2ASQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactonase, 7-bladed beta-propeller-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_566267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASQ0"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASQ0"/>
    <dbReference type="InParanoid" id="A0A1Y2ASQ0"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="360" mass="38867" checksum="A95681377469797B" modified="2017-08-30" version="1">MSDELVLLLGTHGHHIHSARFDPKSLSLTYGTKTPFSENPSWLSRHPTQEGIIYSNGHANGKVFCVKHGPDGSVEVLDEADSGGGGPTHLAVLNDLSGLAIAHYNTGNVTVVPLDGQGRFLSSSISPPNNFIPPYTPHSHARQEGPHAHQIVVVDDQVLVPDLGSNTIWRLKWSEPNGWELVGDIKGFQEGDGPRHCVVHLSGKYIYVLNEITSVLTVHTLPTSGPSQLLNRLTLLPEEDEPHENLMGAAEIVLLPPLTPTSPTLLICSNRDSPNPQGDALALFSVSPDGSQVTRTEQEWVKGVGKHLRGLTVDKTGKWVCCAARNGGGVVIFERVGKDGLELKEVARLDLDTTVAPLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT13</accession>
    <name>A0A1Y2AT13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BCR39DRAFT_543279</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT13"/>
    <dbReference type="FunCoup" id="A0A1Y2AT13">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AT13"/>
    <dbReference type="InParanoid" id="A0A1Y2AT13"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="37"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="219"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="478"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="575"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="667"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="750"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1126"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORY25614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1220" mass="137436" checksum="28CACF2A9F6E1254" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATR2</accession>
    <name>A0A1Y2ATR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">BCR39DRAFT_544306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATR2"/>
    <dbReference type="FunCoup" id="A0A1Y2ATR2">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATR2"/>
    <dbReference type="InParanoid" id="A0A1Y2ATR2"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY25325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="357" mass="39034" checksum="85D7A0347AA11892" modified="2017-08-30" version="1">MSLDIDWSLLTCPTSSSLTTSLITSLNSALQTASRPSFIGPITVTAFSFGSAPPDVEIKDIRDPWRVFDEIDEEEEEEEINDDDDDILHGDEFEDQQVSSPLDDEVYDFVSPYTAYEAEMDEVGSVYSGIGSARGSVAAVGLGPGFARRGFMSPSLSLNRLQHQHQYPASTTRIPAIPLSSQQRHPSSRLPRSSNLRPTSSPPPSPPVRPRGLAAKPPSSIPSLQLHLRLSHTSDLTLTLLTSLQVNYPSQLFMSLPLKLSITGLQLAADLVLAYSGDKHRVHICVVDDDDNNTKPSAASVPIGMRLLPHLQIESEIGHADAHVLRNVGKVERFIADVVRKTLVDELVFPNFHTIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU92</accession>
    <name>A0A1Y2AU92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_274127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU92"/>
    <dbReference type="FunCoup" id="A0A1Y2AU92">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AU92"/>
    <dbReference type="InParanoid" id="A0A1Y2AU92"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="319" mass="35434" checksum="35D9C2D7418A1511" modified="2017-08-30" version="1">MSQHTTDNNYGYVPSEGWAIAFVVLFSLSAIVHTAQATYSKYWIVYPTLVLGAIGEIIGWSARLWSSQNVYLLTPFLMQISSLIIGPVFFSAYCYILLGMAIKRLGPRYSVLPWSWYFFTFIGADLISIVLQGVGGGQASSSAASGSPTQSATNIMVAGIIFQLVSMVVFLVLGIDFLLRATNKRPYAFQERRIARRSDKKAAAKAAKNAEEGVIRSDSDGTRVGGEERKELVETIEAEENLTAWWILLGGVLLASVMIILRGLYRSVELVQGWNGVIIQTERYQNCLDGIPMLITLLAFNFIHPMFLLPKKLTRRGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVC6</accession>
    <name>A0A1Y2AVC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_261103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVC6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVC6"/>
    <dbReference type="InParanoid" id="A0A1Y2AVC6"/>
    <dbReference type="OrthoDB" id="2218151at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="61"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="369" mass="40551" checksum="E1C915E4F3B54F97" modified="2017-08-30" version="1">MEKLRSLTSKLPTFSSSSPSSKLTKAFRFNKSTGVLGSPNNSGNPFSDGQSYEDASLPKVHLILHCVALFFTFLAICTMAAVAAFQAKWFSVSGGTGFTLFILILSFIISALLVMVPVIYDRWDKLKRPAQFFAQTRSTLILHAFGTGLMILAAFIVTISAWTEKGCKDADNDPHSSLGDSFKSGLKQWCNTKKASAIFDWLSFGAWCGLLVLSALLFRRERRRDPSFTAPADYPTSSGVGISSSMTYSNMPDHDDHHGERYYNKESSHVDSTDPYAVSAARAYSYSQPQPRPQPQQVARGSVDAYGAFDDDSMPMEESSRTMQLAYDDPYSQIRANLMSTPAPGGYVQPQGTLYSQGGLPNPPTYGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVJ8</accession>
    <name>A0A1Y2AVJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_589765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVJ8"/>
    <dbReference type="FunCoup" id="A0A1Y2AVJ8">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVJ8"/>
    <dbReference type="InParanoid" id="A0A1Y2AVJ8"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="38"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY26247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="338" mass="39857" checksum="5D19AF31B8C7E4C2" modified="2017-08-30" version="1">MAGGRSVSRVYANVNEKLGRSWWDYDNLVVQWGVQDNYEIVRKVGRGKYSEVFESVHLPSNQKCIVKVLKPVKKKKIKREIKILQNLAGGPNVIGLLDVVRDSQSKTPSIVSEYVNNTEFKTLYPKFTDFDVRYYMFELLKALDFCHSKGIMHRDVKPHNVMIDHERRQLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDYQDYDYSLDMWSLGCMYASMIFRKEPFFHGHDNADQLVKITKVLGTDELYAYLERYEIDLDSQFDDILGRYPRKPWSRFITSENQRYISNEAVDFLDKLLRYDHQERLTAQESQDHPYFAPVREAAAKQERSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVX1</accession>
    <name>A0A1Y2AVX1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_274050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVX1"/>
    <dbReference type="InParanoid" id="A0A1Y2AVX1"/>
    <dbReference type="OrthoDB" id="5421239at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009976">
        <property type="term" value="F:tocopherol cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025893">
        <property type="entry name" value="Tocopherol_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35309">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35309:SF4">
        <property type="entry name" value="TOCOPHEROL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="336" mass="37469" checksum="B42759300BAC945F" modified="2017-08-30" version="1">MTSHNSPHPSAIFEGWYSKFRLPSGSSIALIISSVPHARPPAKKKYMISFNYVSPDGSTWWQRETWPEKWEVTNGAGGDFTIQWEDGRFGATGQTMFWRLESADIQFIATLPTRGVPWKPDDQASTPAGLLTRLPLPIQWHVHTVDAPAEFTLNLKDTKLYPGDEQGTAQVHAEKNWAVSFPKSNIWIQARDHDRHRGVSLAGGSLFPGVQAYLVGYHGNSFHDFSPPSSTSLFGLSLGLKSHVDSTKGEAEVDIKGWFSRIRIFARADTETFFTLAAPLDTGHAEGWTAQSFAAVIDVEVYQRSWPWTGWVKVDGDRFERGSLEYGGSLYKAHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWD0</accession>
    <name>A0A1Y2AWD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_560299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWD0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWD0"/>
    <dbReference type="InParanoid" id="A0A1Y2AWD0"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33160" checksum="8378615814FFAD7B" modified="2017-08-30" version="1">MAPTVALYNHNGMVGSHLLRYLLAAHEAGLIILYILHRSGSNIDAIPQGIETRVVNFVKDSPNFDAELNRRAVQGINVFISAAAKADLVNQVAILEALSTSTELATFIPSEYGIYWTEEDYTHDNLKLAKFKDQLVDLAKSLNIPTTIIKVGSIPETTFGKVPDSGINVKENKVSFYGDARTRKTILASLEYIAAGVIELITTHKPSELANKIYQFIEYEPTGEEIIQALTVVHGRPPLIHINTEEELAEQYLKSIQEAIGAATKYKWGKVGFETPGERVTVKSYISIGLEAELKRFATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWG7</accession>
    <name>A0A1Y2AWG7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_540053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2AWG7">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWG7"/>
    <dbReference type="InParanoid" id="A0A1Y2AWG7"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1290"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1597" mass="181320" checksum="EA03738E49A2478C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWK0</accession>
    <name>A0A1Y2AWK0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PUA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_470304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWK0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWK0"/>
    <dbReference type="InParanoid" id="A0A1Y2AWK0"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="156" mass="17016" checksum="B558B5A943DC51B7" modified="2017-08-30" version="1">MEASTDAIHAPTVAGISGNAIDGAYSVALSGGYPDDIDLGIAFTYTGCGGRDLKGTKQNPKNLRTAPQTFNQSFDWPYNAALKRSAETRQPVRVIRGFKLDSPFAPATGYRYDGLYVVEKAWMAKGLTKGLLVCRYAFKRLTGQPDLITRDEDDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXZ2</accession>
    <name>A0A1Y2AXZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_589152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXZ2"/>
    <dbReference type="FunCoup" id="A0A1Y2AXZ2">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXZ2"/>
    <dbReference type="InParanoid" id="A0A1Y2AXZ2"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="97"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY27441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="233" mass="25403" checksum="2D92FFEC58CD97BE" modified="2017-08-30" version="1">MSIRAPLRALYVATRVSTASSSQHSIASSSTLCSAFSKLNIARSITTSSSNAASPSSSSSSPAGFSASQPPSVIQPVDPLIAPRGYSPLAIPPLVDPILDLFTNLLMRHGKKGEAQRRVAHILELIQKTTNQPPVALLHRAVYMAGPAVKVISIKKSIKTTPAPRPMFERQRVRQAIIWIFKAADPGRKGGIPREVRIAREILRVLEGESQVFKWLEERHKAAALARSNIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY95</accession>
    <name>A0A1Y2AY95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_539795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY95"/>
    <dbReference type="InParanoid" id="A0A1Y2AY95"/>
    <dbReference type="OrthoDB" id="2575002at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="600" mass="66875" checksum="29B0C09A14B4227A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYJ4</accession>
    <name>A0A1Y2AYJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_560089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYJ4"/>
    <dbReference type="FunCoup" id="A0A1Y2AYJ4">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYJ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AYJ4"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000026">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="170" mass="18559" checksum="C4E5F4EA7FD50D71" modified="2017-08-30" version="1">MSYGGLIGKFSNNWGSCFSCTLSQGVDSQAMSTRTVDIPADVKDELKKFRFAHRKGSSALSVKIVKSSLTMAVDEELKDMSVEEIADELPENSPRYVVLSYELKHKDGRISNPLLLINWAPSGSPTDLMTLHASSLSYFQQTAEVAKVLEVREGAEGLTTEAVDAKLLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZH4</accession>
    <name>A0A1Y2AZH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_536664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZH4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZH4"/>
    <dbReference type="InParanoid" id="A0A1Y2AZH4"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="354"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="540"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="783" mass="85591" checksum="78E4FB522A5CF297" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0W7</accession>
    <name>A0A1Y2B0W7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative DNA recombination and repair protein Rad54B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_534767</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0W7"/>
    <dbReference type="FunCoup" id="A0A1Y2B0W7">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0W7"/>
    <dbReference type="InParanoid" id="A0A1Y2B0W7"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="250"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="578"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY28461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="816" mass="91503" checksum="795AC4C89B92DD6D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1F2</accession>
    <name>A0A1Y2B1F2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_559446</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1F2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1F2"/>
    <dbReference type="InParanoid" id="A0A1Y2B1F2"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="107"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="220" mass="24083" checksum="671486C07695019E" modified="2017-08-30" version="1">MSRTGSAVALSPSPSISSLTSEEEAFDHTVRIQPESTSILGLREMASLKRLERDNQAASRRDAMSKRKIELLKAVHPSLKSGEGGDQGKAGRVSPVSGTFASDVRIRGWKMVGGRTWSDKAKVGAYVVYEIEIVLRSGGSMEILKRYTDFVVLRTALKAAYPHLRQAIPQLPGKSHLSKFNPDFLADRQPRLQRFLRTVLLHPEMGRGGQGSVVGGWVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1L8</accession>
    <name>A0A1Y2B1L8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_468345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1L8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1L8"/>
    <dbReference type="InParanoid" id="A0A1Y2B1L8"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="26"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="201"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="709" mass="77752" checksum="AE41EDB23F1EBF50" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2E3</accession>
    <name>A0A1Y2B2E3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_533426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2E3"/>
    <dbReference type="FunCoup" id="A0A1Y2B2E3">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2E3"/>
    <dbReference type="InParanoid" id="A0A1Y2B2E3"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="65"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="474" mass="51129" checksum="35C737102A15700A" modified="2017-08-30" version="1">MSHRSLAPAFQRLISVRRRPSFPLTRSLSTSTPLLNTAESSQRLPAARPRKSSLAPELIPPPTALSALLARLNIPADQDFHPDLITCLTHPSFNDPRGQADKDEPPLQDNEPTNELFCAIGNSLLGLFAAEHLAAQYPLLPTEALKLAVTAYVGHKACFSVARELGVGVQSAGNSGAVGRGRGLQSAGIPVRWRRTQRYEDEGGPERIAFGRRFRRHMEGQARLEEIEEQGARSKRVEGFEEVVAATVRAFVGLIYQEMGIHAARTFVHAHFFTRHLDLPSLFNFKNPKYLLSGVVAKQLVEAGVSPNSGLGRIEARLLASTGAHSASPIFNVGLFLPTGLKLAEGHGSSLKMAEHRAAVNALLSVFLVRGDQGHRIGTIPDRPKAKAGDIYGDGLPTRAHVDFPMDLDGVASGTSESEISEYHGSSWGGGEVEIESSKRRAWEGRVGGKGRAASATRGDPVVSTPDDHSQVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2J7</accession>
    <name>A0A1Y2B2J7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_533830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2J7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2J7"/>
    <dbReference type="InParanoid" id="A0A1Y2B2J7"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="100"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY28780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="317" mass="35483" checksum="E1F049907E451A95" modified="2017-08-30" version="1">MPRLETDQPSWSSRIQSLPRDVLHRYHRLGRKGKTAVWGVTALHLLALALVVIITPTRIGGWFNTFAQHLKGLGAGGVAICFLMVVLASHPPLFGFMGSMTLIGFIYGMWPGAMIAVLASMSGSAFAFLSIRSFFLHWIRKYSNPKWEAFANVMRAKGLPLVIMIRYCPLPWAMGNGLFASIESVKFWHFMVANLMIQPRLLIPVFIGSRLTSLTSETPGHDPLRFWLNIGSIALSASISVLTGVWIYRLTLDQMRKLEKSREGELAAEALEEGALFGEYRDSDDEENEDEPLTERSQMLRPERGALRRVSSSGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B336</accession>
    <name>A0A1Y2B336_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_559514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B336"/>
    <dbReference type="STRING" id="71784.A0A1Y2B336"/>
    <dbReference type="InParanoid" id="A0A1Y2B336"/>
    <dbReference type="OrthoDB" id="2597030at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="447" mass="49281" checksum="FEE2E7DAEE623187" modified="2017-08-30" version="1">MANHDRKSSYGLGIDDVVVESRSTSITPLNRPTNAKSPSPLIRSTEANQTSTYLSKLIDDPRNSPASTRLLKIIQSEAIALDTYAGLKLLELAEDMRVDGPLGPKEIHQANENEKEKEKEKEKDTMAIENRLNDFAEMLNVIAEAVGVNLLENDDDLSTTTTGAVLDTNSKLDQIPSPSSATYSESIQRRSLIDTDLEILMPDVVYANERSNLINVNEFEDDDEDNATEPEVKREKVKAEGKDVEEKRHEDEDEDEDAAQSAVAYIPAVSGSSPQYSPTVAAGLGPLDLTDRDAFTSERQVLHGSQGSSLKRLLDPAQTLAENLEVPVYVDSAASMTVEGPSSRGTSPCYPESTAAPENTPNRPNQWLYTSPILPVIPRYHPYEAVDHARRNLFPLFPHGSSSHIQARPLPRTPVSTIAPPPSMFHGNSWAGDVHPDWMRFVPNNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3D5</accession>
    <name>A0A1Y2B3D5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_174537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3D5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3D5"/>
    <dbReference type="InParanoid" id="A0A1Y2B3D5"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="144" mass="15168" checksum="CDFB923F6E9BA15B" modified="2017-08-30" version="1">MPPKGAKLAPPPSVIDDQSPAAVQQTSVLSSIADFELPKTNLTKLAKGSIPDNVKMQQDVVLALQRSSTLFISYLTAAAHDQALARSGKSITASDVLKAITELDFGPADVLIPQLEQELAGELFLSLNVISQNALMICLALLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4X2</accession>
    <name>A0A1Y2B4X2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Telomere stability and silencing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_532775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4X2"/>
    <dbReference type="FunCoup" id="A0A1Y2B4X2">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4X2"/>
    <dbReference type="InParanoid" id="A0A1Y2B4X2"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="10">
        <location>
            <begin position="77"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="258" mass="27448" checksum="35E8906B63467076" modified="2017-08-30" version="1">MDVQTLFINLPHPLTSVQLRLSADTPLADLPIPSLQNTYLRTPSSGPLSPRTTLASLRHASNPSHPITLDVCARILGGKGGFGSQLRAAGGRMSSGKATNVDSCRDLSGRRLGTIKEAQRQAELLESAPALRAQTLAAEKAKLEAIERSLGISAPGEGEGSSSSVKRLAEVDLEELARKKHKFDDNQFLEESREINDNVRSAVAAGLLKKKKKPKTDAVVAGKEKEKDKVEQAKAKDKAKMPPPPTVIKAAPLAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B572</accession>
    <name>A0A1Y2B572_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative structural constituent of ribosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_530439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B572"/>
    <dbReference type="FunCoup" id="A0A1Y2B572">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B572"/>
    <dbReference type="InParanoid" id="A0A1Y2B572"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="160" mass="17873" checksum="2E4BA586F924519E" modified="2017-08-30" version="1">MNCRANQGNLSSIHLISTKMAAAKGLATDRRKSRKAHFAAPSGTKRKIMSSSLSKDLRGKHSARSIPIRKDDEVLIVRGKYKGREGKVIQVYRKKWVIHVERVTVEKSNAATVPVGIHPSNVVITSLKLDKDRRAILDRKSNKSSEKQEKTESADVEMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B579</accession>
    <name>A0A1Y2B579_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_558789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B579"/>
    <dbReference type="FunCoup" id="A0A1Y2B579">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B579"/>
    <dbReference type="InParanoid" id="A0A1Y2B579"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY29963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="275" mass="31080" checksum="4A4C57B2376D975B" modified="2017-08-30" version="1">MRYAVLVTGPAGAGKSTFCASLITHAQTLGRTVHLFNLDPAAERFEYEPSVDIRDLINLQDVMEELEFGPNGGLIYCFEYLLNNLDWLDEELNSYEDDYLIIDCPGQIELYTHVPLLPRLASYLSTNLNFRVSATYLIDSQFMQDKSKFFAGVMSAMSCMLALGISMVCIMSKMDLVKDKKGRIRPEIGRYLDPDPELLLEDVNSTTNPKYHALNRAVVSLIEDQNLVSFLPLDVSSEDSVNTVMSHIDNMMQYGEDEEPKIPKDMDEGDFEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B580</accession>
    <name>A0A1Y2B580_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_564987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B580"/>
    <dbReference type="FunCoup" id="A0A1Y2B580">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B580"/>
    <dbReference type="InParanoid" id="A0A1Y2B580"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="124" mass="13666" checksum="2120DEFF2C199139" modified="2017-08-30" version="1">MANLGVPVKLLHESLGHIITVELKTGEMYRGKLMEAEDSLNIALREITVTARDGRVSQLEQVYIRGSMIRFVIVPDLLAAAPMFKRVGPNAMRGRGIGAARGRATIQRANARRGTTRTNQGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5U5</accession>
    <name>A0A1Y2B5U5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_153929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5U5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5U5"/>
    <dbReference type="InParanoid" id="A0A1Y2B5U5"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000061">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="353" mass="39824" checksum="6B27FDF857660535" modified="2017-08-30" version="1">MRSQLPNLLLASEQYKTVALCDLSLQALELCGTRFGIPKEGLFTDVSAMLASSLPIDLVLVLTADQYHAEHVIACAAAGKHVLIEKPMAQTLAECEAIEAARVKYGVVIFVGYMRRYATALERVKEAIKGKKIRYVRVRDIIGNNQYFTSQAGMHLRYFRDIPASASSDLSSRKLSNLKENLGDKWDSDPRNMHSWSLLGSLASHDLSAMRDLLGMPQKCLCSTRSNEDDGTSSWWWTAIFQYEGFKAYYEMGIDQVAVFDAHIEVYTNDSRVKIQYDTPYVKGLPIKLTIQSQAPNGDFEEKVIRPTYEDTYTLELQELYKVLIEGKEYKTTPLDARNDTILAKMVMDALVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B638</accession>
    <name>A0A1Y2B638_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_532155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B638"/>
    <dbReference type="STRING" id="71784.A0A1Y2B638"/>
    <dbReference type="InParanoid" id="A0A1Y2B638"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="67765" checksum="C7919BFDFBA2DF61" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B639</accession>
    <name>A0A1Y2B639_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_153271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B639"/>
    <dbReference type="STRING" id="71784.A0A1Y2B639"/>
    <dbReference type="InParanoid" id="A0A1Y2B639"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="357" mass="39649" checksum="6AE3EDCFC80849E4" modified="2017-08-30" version="1">MPISTSNKPRVTVLGSGVVGLTAALELAKTYDVTIVARNMPGDPPSLGWASPWAGAMWFGVDGSTPAQKKMQRASFDKFWKMAETMPESSAKRIDVFDFQNKTDISGESGLWYNFMPNFRYLEASELRLGAGSGMFYTSCVITPDTYLPWLQAQCVEAGVRFIRQEVTSLRQAAQFVPCEVIVNASGNGAKFLVDVNDETCHMVRGQVMLVKCAAPAIHISHGKHWSEYTYVLPRGDGTAIIGGIKEFDDVEPAPKEWLRKSIHERCRKLLPEYIPEKFEDLEIVRDQVGFRPEREDSVRVERELLPSGQKAVHAYGAFFIVFSCARWLIGEGLTGGGYVYSWGMAAEVARLVDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6L1</accession>
    <name>A0A1Y2B6L1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative xylitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_529463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6L1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6L1"/>
    <dbReference type="InParanoid" id="A0A1Y2B6L1"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="33"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="404" mass="42703" checksum="56DFFC54F4F32CDC" modified="2017-08-30" version="1">MSDTLTNGVSTLTVAPGATLNGKTSQKAAVCYGATDLRVEDRPIPVPGDGEAQIQVAVTGLCGSDLHYYSHGANGTFKILSPMVLGHESCGIVTALGPNLPPTCTLKVGDRVAMEVGLYCKTCRFCKVGRYNLCSQMRFKSSAKTFPHLDGTLSEVMTQPVDLLHKLPSTLELPLAALAEPLSVVLHAFRRAHLAPGARVLVLGAGAVGLLACTLARASGCTTVVAVDIEQGKLDFAKEMDWATEIFALPKGPRVSGLDAVAAAQNNWAALKADAAVQNVEGLEDGFDAVFECTGVEVCMQMAVMAALPGSKVMFVGMGTPNLTLPTGPSFLREVDLIGVFRYANTYPDALALLGSGKLGDVGKMVTHRYPLENAAEAFEDLKRGRDKEGRTIIKPMVGNLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6R1</accession>
    <name>A0A1Y2B6R1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_466407</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6R1"/>
    <dbReference type="FunCoup" id="A0A1Y2B6R1">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6R1"/>
    <dbReference type="InParanoid" id="A0A1Y2B6R1"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="302"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY30529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="351" mass="40373" checksum="257D74F9E4EEA4BF" modified="2017-08-30" version="1">MTSMDLRVGGKYRIGKKIGSGSFGDIYLGVNIVSGEEVAIKLESVKAKHPQLEYESKVYKSLAGGVGVAFVRWYGTECDYNAMVMDLLGPSLEDLFNFCNRKFSLKTALLLADQLISRVEYIHSRNFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHLHIPYRENKNLTGTARYTSINTHLGVEQSRRDDLESLGYVFMYFLRGQLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFAIYLNYCRSLRFDDKPDYSYLRKLFRDLFVREGFQYDYVFDWSVAPGPKPVAQDDGMGGHSGGMQGQTTVKPRVRPEDQVMDTQRQLRSQTRNNTREQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6V5</accession>
    <name>A0A1Y2B6V5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_466493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6V5"/>
    <dbReference type="FunCoup" id="A0A1Y2B6V5">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6V5"/>
    <dbReference type="InParanoid" id="A0A1Y2B6V5"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY30572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="96" mass="9962" checksum="35FBB6950630614B" modified="2017-08-30" version="1">MSSAPSVSTSPLPLTAPIPSEDVIARKFDNCVADLIVNAGLGFGVGIVASVLIFRRRGWPVALSTGFGAGVAYSNCNYSLNPHVLPGTKIFPSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6W2</accession>
    <name>A0A1Y2B6W2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50B-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_111009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6W2"/>
    <dbReference type="InParanoid" id="A0A1Y2B6W2"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="263" mass="29091" checksum="49548AB3111D3715" modified="2017-08-30" version="1">MAPDMHATLDSVLSAAQHRNLHVFVSRQDTTPNNFQTNTIIAACVMFLAILIMWNVPILRDVIAGLKLFVVGTHELCHLTVGLLCGGQVVSVCIDPNDGGATHVMGLMRTYPRIPRDPYAMPTYTQLFWSTSAVATLAAGYIGSSVVGWVFIFCSFDIVASKIAALVIHFGLLAPVLRADHWIAFGSIIVCEGVLVGFWFGDHGSTLRFYVLFVGMMNLFYVVWDYVDERLFDKRNTSDCAQFSELLGWPTSGLCRGFPKRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7E8</accession>
    <name>A0A1Y2B7E8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_152090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7E8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7E8"/>
    <dbReference type="InParanoid" id="A0A1Y2B7E8"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY30397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26591" checksum="E56C2E507F0DD182" modified="2017-08-30" version="1">MSRRIAIIIGAGPGLGSSIARALLPTHSLVLLSRSLPGSLPKLGLGQVSDDTVLACSSDGSRDTLDAAVEQMKKKWPEGTVDVGVFNTGGAAWSPGGFLDQKIDDLKANVDNNIYAAFNFSQTILPLILDSEPNPTTKGRGTLLFTGATMSLRGGAKFSAMAPPMFARRALAQSLAREFGPKGVHVAHIVVDGQIETERVQKMSQVTDTEDKRLHPDDLAQTYLALINQPRSTWTQELDIRPYCETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B806</accession>
    <name>A0A1Y2B806_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_528546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B806"/>
    <dbReference type="STRING" id="71784.A0A1Y2B806"/>
    <dbReference type="InParanoid" id="A0A1Y2B806"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="529" mass="56838" checksum="5211916A856853BD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B890</accession>
    <name>A0A1Y2B890_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_528039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B890"/>
    <dbReference type="STRING" id="71784.A0A1Y2B890"/>
    <dbReference type="InParanoid" id="A0A1Y2B890"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="171"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="431" mass="47475" checksum="027EB25C47C7E497" modified="2017-08-30" version="1">MSPKQWPTIVKLETFIPSAHGSGGDYHRQGAEHWIVAGNISCPMHKYPEYRSSRTSWGIGVLGSIFVKLTASDGTVGYATGFGGPPACWLIEEHFKRFVIGQDPRDTNKIWDMMFRASMFYGRKGLPLAALSVVDLAIWDLVGKIRGEPIYKMIGGRTKKDIPLYLTGPKPDVAKKLGFWGSKVALPHGPPDGHEGIRKNVQYLKECKDLVGPDYPLQVDCYMSLDVPYTIALVRAVEKAGVEINWWEEVLHPDDFDGHIKLKEALPHMKFTTGEHEYSKYGFRKLIEVRAVDIIQPDVMWLGGLTELIKVAAMAAAYDIPVVPHGSGPYSFHAIMSFPNSDFCEYIANSPDGSSIAPSFGNLFTNEVLPLNGRVNLGDEPGFGLELNPAAELIPYGHFFSVSRSLGSAGEADIKEVVEAEETGKINGLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8H8</accession>
    <name>A0A1Y2B8H8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_528524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8H8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8H8"/>
    <dbReference type="InParanoid" id="A0A1Y2B8H8"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="201" mass="22209" checksum="31EB65D6659970D4" modified="2017-08-30" version="1">MGLRKPHKPSEYPSFLLYFLDQTHVTVTAVTASILLYTRSPHVLWFSIGALGSSLTAKTIKPLIGESRPPPPPPASSRSSPVRPKRTYGMPSTHSTALTFYSIYLLFNPSFSSSLSQLVPSPIPRFAVQSGIQVFCIAGIWSRVQLGYHTLLQVFAGVLLGTLLALAWTTIWESRRSHGLEYALQASIDYLWSLTGQRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9S2</accession>
    <name>A0A1Y2B9S2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_93582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9S2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9S2"/>
    <dbReference type="InParanoid" id="A0A1Y2B9S2"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="264" mass="27906" checksum="96777114A1725854" modified="2017-08-30" version="1">MDASSLFNVKGKIVLVTGGGRGVGEMIAAGYVANGAKVYISSRDKKACEETCKKLNQLGPGECTALPADLSKFEECQRVVKELGKREKMLHILVNNSGATWGDTLSTYPDSAFTKLLTLNVQRVFTLTQGLVPLLTKSVEAGHGVARIINIGSINGINVPGLETYAYSASKAALHQMSKHLAANLGPKITVNTLALGPFRSKMMQATLDSFESEIASALPMQRIGRAEDVVGACLWLSGKGGEWVTGTVVPIDGGSLIVSNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA96</accession>
    <name>A0A1Y2BA96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_93370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA96"/>
    <dbReference type="InParanoid" id="A0A1Y2BA96"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="85" mass="9400" checksum="F9EEAFFF8EC1681A" modified="2017-08-30" version="1">MSRMVCCVACGQARHVLGCRCNFVRPSVLDTYCNNRTIQIHTIPITTTTAFILLTGMMEYGVSNPSSTHSRSEAILMQSINFNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB00</accession>
    <name>A0A1Y2BB00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_71869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB00"/>
    <dbReference type="FunCoup" id="A0A1Y2BB00">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB00"/>
    <dbReference type="InParanoid" id="A0A1Y2BB00"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="43"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="204" mass="22573" checksum="346590439B0B28F9" modified="2017-08-30" version="1">MASVTLPNDVLKVANEGTVKLFGKWDAQEIEVKDISLTDYINVNHAVYVPHTAGRYAKKQFAKGRMPIVERLVNALMMNGRNNGKKLMAVRIVQHAFEIIYLVTEQNPIQVLVDAVVNTGPREDSTRIGSQGTVRRQAVDVSPLRRVNQAISLLTIGTRESAFHNSKSVSECLADELVNAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB55</accession>
    <name>A0A1Y2BB55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_587209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB55"/>
    <dbReference type="InParanoid" id="A0A1Y2BB55"/>
    <dbReference type="OrthoDB" id="2573713at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="195" mass="21117" checksum="AC6B68E6A44FA604" modified="2017-08-30" version="1">MLLKKESALAAILPLHRNACSDVLRQSQRSLGNIETHNRGQRSACPNLYCCQHSSPPFCRFLSSIFNRYNKETGGNLANMPMNINPYMIHHPLVNPQELPFPTVVLPGGGRVAIYPAVRTRYPGPNIGIGAGGMGMPHPLGGPLGWGAGVGIDNTAAAWRRYVGLGGFLTGYPIDMRLPGRPGLGGYWGGWELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBC5</accession>
    <name>A0A1Y2BBC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_526424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBC5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBC5"/>
    <dbReference type="InParanoid" id="A0A1Y2BBC5"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="467" mass="49167" checksum="040A95C7B91D8E31" modified="2017-08-30" version="1">MSQQSAFYSIVWACLSSWYYGFHLSELNFPAASLTCLSPAIPPPSRLPLCLGLDTTLYGVVTAAFTVGGLVGSLGSSWVVQREGVRGGIALTGWLNVLGVVCMALAPYWVVLALGRFIAGLSAGVAVCLVPPFLSLIARTSPTLSNRSGQVGTLHQMGIVIGLFSAQAAGLILTGKTGDIPGSWRNVVAISGVISLLQIVAGRFIDGLEHEEKDADVESIAEISGRVESGLAVAPVDDSEASPLLGPVDPSNSSQLPLRELLSNTSLRTPTLLCAAILTLQQLSGVNAVMFYSTPVLRPLMPASAATIGLQITAVNALMTVVAIFLVDRMERRSLLLVSVTGMTLTSALLAWGLDNGHNLLSASVIVLFIVFFAVGLGPIPFLLVSELVPQPAIPALASLSLSLAWISNFFIALLFLPLRDALSEPVDPHDPIGDRKGEGRVFYVFTAVCVVLGLLISRGLRGSREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBW5</accession>
    <name>A0A1Y2BBW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_493409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY32020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBW5"/>
    <dbReference type="FunCoup" id="A0A1Y2BBW5">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBW5"/>
    <dbReference type="InParanoid" id="A0A1Y2BBW5"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="438" mass="47373" checksum="5C2DE20878FF2601" modified="2017-08-30" version="1">MSIQKYRLKPRPGALEAIKEAYSAKNPESKAAFDEAVTVLPGGGTRKTLYVDPFPLFITGGKGQHVTDVDGHEYWDLAGDFVSGLYGKTNPILRSAIMEALDSGIQLGMHTKKEAEFATLIRDRLPSMELIRFTNSGTEANLQAICASMHYTGRSKVAVFSNSYHGGVVADFYPGGARANEPGSLTLKVPFDYLICPYNDLEKTRELVNDLKDDVACIIVEPMQGAGGCIPGTPEFLRGLRELSKAIGAVLIFDEIQTARLAYNGLQGVYEIKPDMTTIGKYFGGGLAFGAYGGRKEIMSMFDTRKAVHVKVGGTFNNSIMTVSAGIAALRYVMTRPALEKVNTLGDMMRAEIMALFAKLGAPFEMTGVGAINEIHCLLPGPEGLSGQHLLFFGLLDKGIAIAQRGLCALTLLAEEGDIHRLTRAIQEVLEGDLFCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBY7</accession>
    <name>A0A1Y2BBY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_492735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBY7"/>
    <dbReference type="FunCoup" id="A0A1Y2BBY7">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBY7"/>
    <dbReference type="InParanoid" id="A0A1Y2BBY7"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06448">
        <property type="entry name" value="L-Ser-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="17"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY32226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="331" mass="35173" checksum="77E8D4ADC5B0ECFB" modified="2017-08-30" version="1">MTVSTSSQANVACPWIRTPLVESKRLSDIAGCRVFLKLENLQPSGSFKSRRGIGNLVRYHVQSHPPSTPLHFYSSSGGNAGLACVTAAYDLGYASSVVVPLSTKPMMIAKIKAAGATQVFQHGATWREADDYLRTEVLARDQGGVYVHPFDDQHVWDGAATLIPEIQEDLRGQQADVIVCSVGGGGLFTGIAQGLGDDSSTQIIAVETLGAESLNASIKARQLVTLPGITSLATSLGATRVAERPFALAQQNNVHSVVVTDAEAVRACLSFADQERMLVEPACGASLAMAYEAKLKDVCADLNKDSRVVIVVCGGSNINLDMLAEYKETYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC92</accession>
    <name>A0A1Y2BC92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_564381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC92"/>
    <dbReference type="FunCoup" id="A0A1Y2BC92">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BC92"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000412">
        <property type="entry name" value="SIT1p Ferrioxamine B transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="596" mass="65069" checksum="465F86B5F9A1FFFD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCN4</accession>
    <name>A0A1Y2BCN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_564234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCN4"/>
    <dbReference type="FunCoup" id="A0A1Y2BCN4">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCN4"/>
    <dbReference type="InParanoid" id="A0A1Y2BCN4"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="68"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="323" mass="35297" checksum="489AD23A6C6CD122" modified="2017-08-30" version="1">MNRSGGEAFARLAQQLNKARLQAQGGGGGRGGSGGPNWNQMPGGAKGFMTGGGLIGALAIGGLLLNYSLFNVDGGHRAIKYSRLHGVRSDIYPEGTHLMIPWIETPVVYDVRAKPRNIASLTGTKDLQMVNITCRVLSRPSVNDLPTIYRELGTDYDERVLPSIVNEVLKSVVAQFNASQLITQREMVSRLVRENLTRRARRFNLILEDVSITHVAFSPEFTHAVEAKQVAQQIAQRAAFLVDQAIQEKQSIIVRAQGEARSAELIGEAVRSNKGFLQLRRLEAAREIANTISQSGNKVMLDARSLLLNVADDDVLQSTNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD00</accession>
    <name>A0A1Y2BD00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_586920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD00"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD00"/>
    <dbReference type="InParanoid" id="A0A1Y2BD00"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="666"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="499"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="618"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="86986" checksum="D99A9E196EDABD17" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD44</accession>
    <name>A0A1Y2BD44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_380380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD44"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD44"/>
    <dbReference type="InParanoid" id="A0A1Y2BD44"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="170" mass="18455" checksum="11E0F02423407BC3" modified="2017-08-30" version="1">MIECGIFERTHKRPRPHQPDDQKLRKSTTLLSREAPMRLQVMSEDSDGDDVDSPSSTVPQQLTPPIGVFQHNSAPLLTASSLDTRRYPFPTPVTTIGAHGHGHTHDGASSPYGYAYSQHHQKRAATFGGAIAAPASTKAPGGDSNPGRMPGWQTMNRHNEIVVHDSQGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDE8</accession>
    <name>A0A1Y2BDE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein MutS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_522039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDE8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDE8"/>
    <dbReference type="InParanoid" id="A0A1Y2BDE8"/>
    <dbReference type="OrthoDB" id="2596045at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="23804" checksum="7934B09276A49748" modified="2017-08-30" version="1">MQGVSAFQLVQGPNMSGKSTFIRQVGLLNIQAMLGCFVPAEYASFRLHDSLLSRLSNDDLVEKSLSTFAAEMATSAMILGMATPRSLILIDELGRGTAPQEGFGLSHAIGEALIRTKAFVYFATHFHDLATTLCSHPGVVNVHLEVEHNRHDPNSAEFGTVFQYRVVEGPNREEHYGLELAKLASLPLKVMTRAREVAYKLTELEDKGLGITGSRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BER5</accession>
    <name>A0A1Y2BER5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_520780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BER5"/>
    <dbReference type="FunCoup" id="A0A1Y2BER5">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BER5"/>
    <dbReference type="InParanoid" id="A0A1Y2BER5"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000014">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="61"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="194" mass="21523" checksum="1A915F2FA252ADCE" modified="2017-08-30" version="1">MSRALDNENPTIFAPTHATSSRRQPKSARALLWDSEADMFQESDMEDGSESEEEREEIDSEEVFDLLRSITDPEHPVSLEQLRVVNPDDIRVAGNRVLVYLTPTIPHCSMSTLIGLSLRVRLLRALPPRFRVDIRIKPGTHQSEHAVNKQLNDKERVQAALENKHLLQVVEGCLATAGQRGVGDGNVGAAPITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEU6</accession>
    <name>A0A1Y2BEU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_519447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEU6"/>
    <dbReference type="InParanoid" id="A0A1Y2BEU6"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF85">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="300" mass="33891" checksum="9C949E96C0EEB3F6" modified="2017-08-30" version="1">MAHKLPKKIDLRPKKYHGFQFLLFLLGCLLPPLAVAVRFGIGKDFFINTFLCICGYFPCHFHNFYIQNIRNNTNRARTPKWALKAGLINNSDNERRLKKSQWSKRFDERNNQSTLANQPLEEGEEGENYVPVSEEDRQAQEHRRREGLWDNNDEEYYNEDRAINQERWHYPANFEGTVGDGRSRGKKANAVNGDRWERSRASRSSSMSSGTYPPAAATDADVPEWGKDYGSKRRSTKNKNAAASAGGQGGWAGGGGYVKDVQRDDAWGGSKTPTPANGNGNAPKAGRQQSQSENIFEHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF65</accession>
    <name>A0A1Y2BF65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF65"/>
    <dbReference type="FunCoup" id="A0A1Y2BF65">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF65"/>
    <dbReference type="InParanoid" id="A0A1Y2BF65"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="419" mass="45798" checksum="5136F63D590A06F8" modified="2017-08-30" version="1">MSTEEPTSAPPPDATPAAEAEPAAKSSSSPSGTKKVARPGRPRTSTAGGSKKQVTSENKSFQHGDIVLARLKGYPPWPARICNPDDLPASVQKSRSGKHPSIYCVQFFPVGDYSWLQAREITSLKAHEIQAYINEPHRKAAGGLMEAYQTAADPTEWDRQQTETRLERENAEAAANEDVDELEDEEEEAEAETGGKRKRSAAEKKDKKKKAKVEKKAKNGNAEPKAKATPKSKSEKSKPTKAPASKPVENQEPIDDDPLASNPECVKVKDWRHKLQRAFLGKGLPTADEMTTYDDLFKTIEKYDTMTIEALQYSKIGKVMKKIATLEGIPRDGDLKITERASKLMKEWSDFITNNESKPNGANGESHQATETETKEVKEDAAPEPAPEPAPEPAPATEDATEPAAEGEAEKIEVDAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF99</accession>
    <name>A0A1Y2BF99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_521473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF99"/>
    <dbReference type="InParanoid" id="A0A1Y2BF99"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="137" mass="16171" checksum="8A85E4792BFF81BE" modified="2017-08-30" version="1">MSRISEISEAHLRHALLHRSSDCHPHCHTHCHTHCHIHCHIHCHTHLHHPSHCHTHCDPHCHDDLHHPHCHPHCHTDLHHPSHCHPHCHTNLCHPSRYHSHAHAQRQSPPEFQPQPHHPYPHDQIESDTHCYHLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFV2</accession>
    <name>A0A1Y2BFV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cse1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_518640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFV2"/>
    <dbReference type="FunCoup" id="A0A1Y2BFV2">
        <property type="interactions" value="740"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFV2"/>
    <dbReference type="InParanoid" id="A0A1Y2BFV2"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="994" mass="110213" checksum="5C23904341A0FD99" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFV6</accession>
    <name>A0A1Y2BFV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_592790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFV6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFV6"/>
    <dbReference type="InParanoid" id="A0A1Y2BFV6"/>
    <dbReference type="OrthoDB" id="3364069at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="419" mass="46657" checksum="A2D236D32A36BA34" modified="2017-08-30" version="1">MSRHALIPAAIQHSSNSFTESTPINYDSQPSQASSSRMAVDDRRVSYGATSSGSEPHSPGMKGKEPAVLEDGEDEYEEIEDGLEPVIDGLITQVTWRYMSRLYLLVPVVTLLFLASMILLVTFAWPPNKQERKAGQRYPHPFLFKPFLIGLFASCTVQTLRVPVWEVISWLQLGPMFTNYSATIIHTTLHELIRMSTLPLVSPSPTSGFHSSYYLGLGWGVAEVTWGIVQGYEQLALYSDVMRPEEIDLEGTGSVKFEVQESEEGRLLESPEIAEIQLQLEDEEELERRVEVLERMRGRRDLEEVIGVPYPTIPFPLHLLWRLDTLLLNLGLTLILSAFYFDSAPIYRHTFHNPLATHPGDAPSKYLWLVWAIVAVVHVGVSLVWKVVGRVGVGAVTWGGLIVALGSVFAGLGAWGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH11</accession>
    <name>A0A1Y2BH11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_518401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH11"/>
    <dbReference type="FunCoup" id="A0A1Y2BH11">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BH11"/>
    <dbReference type="InParanoid" id="A0A1Y2BH11"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="134" mass="15190" checksum="C239819E37BC74BD" modified="2017-08-30" version="1">MSLRLLTWFKSPEGRQYFFSTHFWGPMANWGLPIAALGDIIGKDEETISGVMSPTLAGYSMIFMRFAWRVQPRNYLLFACHATNATAQLVQEARFLNYWYGGGREKKHPIESGVDSVKGKVQEEVDKVKNAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHE6</accession>
    <name>A0A1Y2BHE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_516771</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHE6"/>
    <dbReference type="FunCoup" id="A0A1Y2BHE6">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHE6"/>
    <dbReference type="InParanoid" id="A0A1Y2BHE6"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="18" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="400"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY34211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="558" mass="63142" checksum="3C3BC91A1967BC6C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHY0</accession>
    <name>A0A1Y2BHY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_518882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHY0"/>
    <dbReference type="FunCoup" id="A0A1Y2BHY0">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHY0"/>
    <dbReference type="InParanoid" id="A0A1Y2BHY0"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="167" mass="18695" checksum="95451B7F13B389B8" modified="2017-08-30" version="1">MLIYQDVITGDEMASDAFDVKEIGNVAMEIDCSMIIVKEGDIDIGGNPSAEEAEEALENGATQVNNVVHSFRLQSTSFDKKSYLTYLKGYMKAVKTHLQNTNPDRVAGFEKEAQDLAKKIVGNFKDYEFYVGESMNPEGMVALLNYREDGVTPYFTLWKDGLKEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI38</accession>
    <name>A0A1Y2BI38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HORMA domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_586051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI38"/>
    <dbReference type="STRING" id="71784.A0A1Y2BI38"/>
    <dbReference type="InParanoid" id="A0A1Y2BI38"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HORMA" evidence="10">
        <location>
            <begin position="40"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="448"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="725" mass="79727" checksum="68DFDD616681C47D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ09</accession>
    <name>A0A1Y2BJ09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin fusion degradation protein UFD1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_476155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ09"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ09">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ09"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ09"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="55"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="156"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="484" mass="51961" checksum="C860C44CAC5E4028" modified="2017-08-30" version="1">MNHGYDDDEEEDNPYGLPPRATAGPSGLLAQLMGGGMMGYGGLGRFAREPPPSAYDEYFKAYSVAVMGGNERYELMYGGKIIMPPSALARLTALDISGPWCFELRNPRNPSVNRTHAGVLEFIADEGIVHLPAWMMKTLNLNEGDPIRLTGAKLPKGKLVKLQAQATDFLQVSDPKAVLESALRNFSALSKGDIIEITYNSLTFEFLIMETIPEGPGISVIDTDLEVDFETPVGYVEPPRPAPAPIPTMADKLKIDLGETQSVGASAGTSRSASAASMRPGGSGEATPLESFTGVGQSLSGKRIKGKGLAKKIEEVDPNSKINRNEGPRIITPDSLADADRKVPGPLVLPAGKFFFGFKYTPYDPSKAAKKVDEAPKVTQPFSGEGTTLKSRRTPAASNGKRKADEDAVKVDTEEQPDPWANLGNGNTLSSKPVKSERAETGRIPAAAAPLPPHEVIDATMSDDEDFMYYDAGDDEDIIEIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ16</accession>
    <name>A0A1Y2BJ16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_461747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ16"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ16">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ16"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ16"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="58"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="432" mass="47364" checksum="08BE77A2F7652AA9" modified="2017-08-30" version="1">MPVATIRSPSPVGSEAPSKRPRLAVDPEANLVDEQMALPLEYIKSYDRELDYRNKLVLAPMVRTGTLPTRLLALHYGAGLVWSPEVVDKAIIGSERTVDPDTGIITYSKGQGPIFYTHPMEKPYLIFQIGTSDPELAVKAAQTVQQDVAGIDLNCGCPKPFSTHSGMGAALLSTPDILLNILRALLDAIPLPISCKIRLLPTQPSTLLIASRILRTGIRNLTVHCRTRDMRSSEPAIWDRLSDIVQLGKQRGVPIICNGDGDGWANWESIRNKTGADSVMLARAAERNPSVFSPTGQVDTTTEIFSRLLNIAQRIDNPWGNTKFLLNQFKPSPPPISSKSKAEKKVVIEAIARAKSVEEIAEKLQIQLGRGEEVMRDIEARIREKRDPDMFAERKQAEADGVTADPIVNDISLQHADGFEVGVGQAAIERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ40</accession>
    <name>A0A1Y2BJ40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_514902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ40"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ40"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="200" mass="21811" checksum="FEE4A5E34C8CE4D2" modified="2017-08-30" version="1">MPVKFTPGPHPTSQSRSSSSTSLPHHHLTPNHNSSSNNNDDDDGSQSPYQPTSSTSSPSHIPAVPHSTPTSIMVHKDTSTTTTPKSSIFITPGHRDVSTTPKNSRKPTTPGTSSPLTISFRPRQETLDDVERQPLLGRRHSQQQQDGQQEEEAEEEENRRKWIYPVLVGLGIFSILMLVGLGGWRLGMGEGGGRWPGGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ87</accession>
    <name>A0A1Y2BJ87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_515153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ87"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ87"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ87"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012598546" evidence="3">
        <location>
            <begin position="24"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="372" mass="38951" checksum="88751F9F608ECCEA" modified="2017-08-30" version="1">MLSRSILLSALVVVFSTITTSLAATTCNGHAELCDRLYSNVTFIGAHDSYGVGENVADNQDKDVTQQLTDGVRTLQVQAHNASDGPHLCHTSCTLLDGGLLSDYLTKVATWMSSNTQEVVTLVLVNSDDLPPTSFTSAFTTAGLDSKVYSPSSSSLALSDWPTLGTLIDNGTPLVVFMDYEADFSSVPWIIDEFSNMFEDAYDVTDTTWGCAVNRTSGSASSQMMLVNHFLDTTYTIGNTQFWVPDKDAINTTNSEDSIGSHVTNCLSLWGRNPNHILLDYYDSNGDSPFDLVANLNSVSAPTNTVTAGTVGSTASASSSGTGTGNVATASGTNSKLSAAGRGVNILGGPGVWIGMAIGALGIVGGGMGLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJC7</accession>
    <name>A0A1Y2BJC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SacI homology domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_515226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJC7"/>
    <dbReference type="FunCoup" id="A0A1Y2BJC7">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJC7"/>
    <dbReference type="InParanoid" id="A0A1Y2BJC7"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="145"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="786" mass="89218" checksum="DF0613999F489EDA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJF1</accession>
    <name>A0A1Y2BJF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_515491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJF1"/>
    <dbReference type="FunCoup" id="A0A1Y2BJF1">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJF1"/>
    <dbReference type="InParanoid" id="A0A1Y2BJF1"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="831" mass="90941" checksum="B850F2383F7AAD08" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJL0</accession>
    <name>A0A1Y2BJL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_514782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJL0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJL0"/>
    <dbReference type="InParanoid" id="A0A1Y2BJL0"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="92" mass="10208" checksum="81C9F425D269AA04" modified="2017-08-30" version="1">MASSVRNVVRYTALLSGIGYGLVHQGTLQTKYDAEKELAAEKRRTHLIEEARKAYLSKIATEKAGSSSGLITDPEDPQFDPEKIAEYYSKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJL3</accession>
    <name>A0A1Y2BJL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_556705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BJL3">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJL3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJL3"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000825">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="842"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="938"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="950"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1469" mass="161609" checksum="6959178DF2254369" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJQ6</accession>
    <name>A0A1Y2BJQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJQ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJQ6"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="279" mass="30981" checksum="D0E3BC41737D4EEA" modified="2017-08-30" version="1">MSFLPIQPCCLKRQELPGTPTGVFEPPNEKHKVGRYIAKPPQDSSPVKPATAVVLFYDAMGFGEPNPKILADTLAAKLNLPVFVPDYIPNPPKSHDFDAVMASTPNEYANRAWYKTFWEYMKLIFKIVPYIPSIKDGRVVPLCNTAVAEIKAEGYTNLGAIGYCRGGSMVMELLSKGDRSPLKCGVICHPSPSVPWTEKITLPSSWHLASHDIRFKDPEIAKLRQIMEAKKGVEFSCTVYPDTVHGFAARPNQSSESAVKAFEETHEAAVEFFNKHLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJT4</accession>
    <name>A0A1Y2BJT4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_515311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJT4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJT4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJT4"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="256" mass="26626" checksum="F08653EDF45F1987" modified="2017-08-30" version="1">MASNPDSRPLPEGWVAQFNEEHKAWFYVNKNAPGGPQSQWTHPADDQPFAPPPGPPPSSNPYRADTKERPAYNTGTPSYTNGASGSYTGAAQSSTPPPSQSPVGSQSGKRGIGGFFDKLKGKSQPQQGYGGYPSQQGYGGYQQQGYGGYQQQPQYGGYPQQTQYGGYPQQGYGQQPVYAQQRPQRTGMGAGGAAALGLGGGLLGGMLIGDMISNGQENAYQDGYMNGADNNDYGGGDMGGGDMGGGDMGDMGGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BK32</accession>
    <name>A0A1Y2BK32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_573601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BK32"/>
    <dbReference type="STRING" id="71784.A0A1Y2BK32"/>
    <dbReference type="InParanoid" id="A0A1Y2BK32"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35537" checksum="9CAE688939E6C213" modified="2017-08-30" version="1" fragment="single">QSRQPVFSKAIISPLFAKAIISHSNSYRDIISQPVDIRRLSYFFHSTSYIMTEFEALNSLNMSDPSANSTKKEDDESVKTNITLMFHPDFCLPETLAIIRTADGQNFRFSLPLLAQLSTFFANIVQLNLGLDKTEIIELPSATTPALHIVLCLISNSISTNLSRKPLPYGSTILKHLPEVLTIIDAYDLHIVRPLLAKFASEIFHDEPGSVFTVAALLGDEKLAVIITKSNPSLQIDSTCRYTFAAKYLCRVHEFQNHNREEDSKLEQLIKHSEFVQGGPAHDFINACKKRGGCATYVEYEESPMRITRLSQVLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BK57</accession>
    <name>A0A1Y2BK57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BK57"/>
    <dbReference type="InParanoid" id="A0A1Y2BK57"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="207" mass="22947" checksum="71CC4C6FE5CDF37D" modified="2017-08-30" version="1">MPPILPRRVYTFHPQTVKYCTRDELFYKEKTSQLNALVKKVNNKAQYATALKHWTDPGSSIADIGKRSCSIRVNTATGPRKAWTIPADEAKVYGEIVARTADMINTLLETPSAVSDHDLADRYEDLAKLSDKIGHAKIKRLKRPAVSEPLPPRQRMAAAREEIRKNSGVLYSPTAGPSGTPRTAPQQPSARQSPTPERESEVDGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL01</accession>
    <name>A0A1Y2BL01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_502741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL01"/>
    <dbReference type="InParanoid" id="A0A1Y2BL01"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="317" mass="35435" checksum="62B1841E0DA974EA" modified="2017-08-30" version="1">MYNQGSPDQQPGSNTTVSSPSFQDETKFTPVMVLRATFSSTDSKAIVLSAPRSIRYTPSEGYTLVSLEEGDPSVLSGMDYRNIRIAIDKELEENETLRKRKTASTERFQSAFGNDDESYRALEDWTEVVRDAFRNIYPRFAETFGTTNESYHSGIIHNVTLEGRFPLSAYAEPTYNSFEEPPYTRDPSPSTADWEGSQAGSSAYIVESPPDTGNLEESPFQTIEEEEVNMENEEDAEGEEDAEGEEDAEGEGEGEEDVEGEENVEVEDSQYGSDLRSNPREDASGLPSIPQESSYSMNVNIWKTKYNQTKGWDVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLT2</accession>
    <name>A0A1Y2BLT2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_461612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLT2"/>
    <dbReference type="InParanoid" id="A0A1Y2BLT2"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="233" mass="26676" checksum="31B1F7310AC99165" modified="2017-08-30" version="1" fragment="single">MPPKPHRPFRILALPLARLPGPVTSVPPKPKSPLILYQVLQPERPSSKSTTTAGTGTGAGPDAKPPPKEPLLNRALARASDEWLKLGTKPAGSWMLWFYQRGESLMDRIEYEEWALKSIQEGRGVRINKDGQPEERIEVSNVVKLSTLHRLLMHRIPYHRKMMWRSLAFSPVTWPFALIPIIPNFPLFYVLWRAWSHWKAYRGATYLEQLLKSGLIVEKPSLELTQVYRSRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM56</accession>
    <name>A0A1Y2BM56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial ribosomal protein subunit-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_512440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM56"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM56"/>
    <dbReference type="InParanoid" id="A0A1Y2BM56"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50113" checksum="590104471A924B7B" modified="2017-08-30" version="1">MSSPFPKLLRQSTFSSFDPHITRVYKSTPSSISRHGDWGVKYAVQRAPKHIKLDQLDTGVKAIGADWRSGEREARFMDAWGRGRQSWMSEEDQVEYSLLRAGSSIFSDRSRLFAHELAHPAERKGIESEVMADVNMMRVDEFERYIQRIRKMRKGYRETKVDMLRPQVKETLATPQDRTLVALATRGHVADRDAASFQVDLTKKDITSSVGKLYSQPHRLHGLSYSKLSPTASNVNSILHYPGRALDKAGAGNNNSASSRSASRFGTNAPWIVAMGNTTVKTDSTPRRISDVPAMERGVDYSRQDRDRGAAKWSVTRALLQSPPKVLGLRDSATAQKYIVDRGKIISMAKMPSPLDTTHFNIAVKHAGPIAAASRNEVGTREWVGTEPPPSLSRMRASAGDALGLGGPRRGRVQGEAGATLQSFEARKEADQRTKEIAAKRVADMLSRLGGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM91</accession>
    <name>A0A1Y2BM91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_511661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM91"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM91"/>
    <dbReference type="InParanoid" id="A0A1Y2BM91"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="25413" checksum="B50FBFAFE3E7C9EE" modified="2017-08-30" version="1">MSSSGSSITLSAPAYIIPILHAAAHPSSTTIGVFLSSISTSTSTLPSTTTLPSTTTLPSTTTVPSTTSTLPSTTNTTSGSLSISNIQITDAIPLIHAHTTLSPILEIALEHVIVYAREKGLRVVGVYVAEESGSGGGRIRERIISGLKGLVGGDDAFSLVIDETKLAKGENPYIMYTAPSSKPLDGAVQLVSQDLPSRSLQSIKERRLHADLYDLDDHLDDSSVDWLGNTVVVKAIESQVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMC2</accession>
    <name>A0A1Y2BMC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_513001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMC2"/>
    <dbReference type="InParanoid" id="A0A1Y2BMC2"/>
    <dbReference type="OrthoDB" id="549336at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="505" mass="56519" checksum="E123DDA4FA7C8626" modified="2017-08-30" version="1">MSGITRPRNLLAGLALGLLTLLVLFTSHDRYRQKSFTELRIAVVEHTPYHDEVIGGVLAALYEAEADYDLYRDRLHRGFDEILSDVYPDSPIRLDELVPALDEGKYDVLVIVTGDEKFWGGRDDLLDAMRRSTSTHIICLVHEIEIYGNQKDLAMIAPFAEQERLTLLTLGQHSARTLKTKLSRWAWERGEPMWENVDVVHFAPVFKIPASAKLETPVIECSNTPEDGPPSRVAILGRIHQSNRDYEGIFRDLVIALTADPKPWGYDSVPYTAEQLASLPELALETSAPTHRFVPLEHADPPAFTLHLIGEDLGLVAIPFELTDAEHPIVRIHSNIEYREFYDILGAMDLILPAFSTFTYLDARSSASIPAAVIARTKVLASPALLNSYTYLSPPAYVLAPLSVSEISSIALLRQGRDPWLGTFPQALEKEIDVMSAGWVGVSASSSASWFGNRARASASNWENYERRLAKKNREVWRDMLSRTRGNNGLDSKIEQAIEVMKVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEJ9</accession>
    <name>A0A1Y2AEJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_554570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000122">
        <property type="protein sequence ID" value="ORY20916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEJ9"/>
    <dbReference type="FunCoup" id="A0A1Y2AEJ9">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AEJ9"/>
    <dbReference type="InParanoid" id="A0A1Y2AEJ9"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY20916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="464" mass="50172" checksum="AA6C9E9C7105F94B" modified="2017-08-30" version="1">MSTKPILLLDGGMGTTLESLGADVSNPLWGCQLVHSDPETISSVHRGFLDAGADIIETATYQMTLDLLVAQGHSVDQAKTIMRSAVHLADAQTKVTNRPKVVALSIGPLGATLQPGQEYAGNYPSPYGPFSPSTSISTSTSTSTSTPTSVSPPVPTPVSTFTATSTLTSTSTSSTSEFVTSTNQCPNPVEEDSAEEALTEFHLDRLRVFALHEPTWRTIEWIAFETIPLIREIKAIRRAMTRLKSELEITYGTKDGDGEIAYGTDNAGGEIIDGMENGQGEITFDSGDKHRDRKKEARRWYDKKFWITSAYPLGQHGTKSPNGQSVSTSTIVHSLLDPMIDGDTPNGVGINCTNPTYLSRLVHEFTQATTQSLQGTTAKMETEMDMDMDRPYFVLYPDGGNVYDVVTRQWSEGKLAPNDWAAGIASVVESLKNEDAWGGIIVGGCCKAGFNEIKALRTALDEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AER7</accession>
    <name>A0A1Y2AER7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_554447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000121">
        <property type="protein sequence ID" value="ORY20962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AER7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AER7"/>
    <dbReference type="InParanoid" id="A0A1Y2AER7"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY20962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="497" mass="54407" checksum="FAC06EA6863CA592" modified="2017-08-30" version="1" fragment="single">MPSINEQDDIDLISSPLVLPNGTTVPNRLVKVAMEEGIGFGGGLPTKRHERLYKRWAEGGWGMIVTGNVHVDPQHLATPHCRSILDDTSQTVSAYASLRQSISSSSSLPTPICLVQLSHGGLQSSSTINMSRAPWVQAVAPCEARPNTGSSIWGWLLSRVIWPRKSRRLRYFDDWLEIVDMFIRGARIMHEAGWDGVQVHTAHGYLLAEYLSPLTNPDPIPLPGVPYQIPLRLHLLWLILTGIHAATDHKFIKAIKINSSDFVQGGLDEVQAAQVIKEIVSWELVDILEISGGSYSNPAFASLDALHAPTRQSLFSHFTTSLIPHLAPPPKGPAILLTGGLHDRTLIASSLRDHACHLVGIGRPACVKPCLPHEIILNRDIPDCDSAIGGYTIPGGEAWKRFLGGGRSSSASPVSTYTEVETESSPLVAKHTQPAGVPLVGAGISTFWHEWQLSRISRGKEPWMDMGWGVGAVWEGVVWGVFKGFGVALWRDWRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFJ5</accession>
    <name>A0A1Y2AFJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_64728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000112">
        <property type="protein sequence ID" value="ORY21378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFJ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFJ5"/>
    <dbReference type="InParanoid" id="A0A1Y2AFJ5"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="528"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="589" mass="61780" checksum="F80B15E100C48921" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGF9</accession>
    <name>A0A1Y2AGF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dihydropyrimidinase</fullName>
            <ecNumber evidence="6">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_554251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000119">
        <property type="protein sequence ID" value="ORY21035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGF9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGF9"/>
    <dbReference type="InParanoid" id="A0A1Y2AGF9"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="81"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY21035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="527" mass="57384" checksum="85BAA3D0A77884BD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI23</accession>
    <name>A0A1Y2AI23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_591391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000098">
        <property type="protein sequence ID" value="ORY22122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI23"/>
    <dbReference type="InParanoid" id="A0A1Y2AI23"/>
    <dbReference type="OrthoDB" id="2594643at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="210"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY22122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="600" mass="65876" checksum="68A61E1637C88C99" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI96</accession>
    <name>A0A1Y2AI96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_388745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000096">
        <property type="protein sequence ID" value="ORY22236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI96"/>
    <dbReference type="InParanoid" id="A0A1Y2AI96"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="153" mass="17759" checksum="FA1AD45FD784A96A" modified="2017-08-30" version="1">MSYFDDHHPVHFGLVRFQSTEAYELSVKASKRFTFDDVIPRLVLLSFALPKEVTAENIELYGLTSQSLSYRSSDSRLLLSLWVARLINVSLRFKVRNSIRFQHSCQPNAVIISGEKSTEADCMIQEMHCRALEILQGEDITLYYDQDYCQYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ46</accession>
    <name>A0A1Y2AJ46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cwf21 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_455542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ46"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ46"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ46"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY22591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="174" mass="19364" checksum="ABE6628F801EDB93" modified="2017-08-30" version="1" fragment="single">YNGIGLSTARGSGTNGYVSRNTAALQIRQGPPGGGPGGQGQGRYQDFLDELTGPPVHRQPDQGILEHERKRQVEVRCLELRDELEEKGLDEDAIDEAVQILREKLTAKSALLDRGRATDSHSIAAAKQVEMTRLQRALGVSANHVEGKAFQRETEEERAKRLAEREERDRQRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJQ3</accession>
    <name>A0A1Y2AJQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_473921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJQ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJQ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AJQ3"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="275" mass="30632" checksum="77E31FA1BB4D48CB" modified="2017-08-30" version="1">MGLRSCLEVLFAQRASLPKEPEKLAPSTPAPSTSTSNSTPSRRSYHDVLSFDLSSLVGGRDSKSPKYPEKLLKVLDTTLQRIAMGQEPKFSDQRFRRTAASFWSTTWPDKTFQRQMRESRKIEDLILPFVTSATKSLKKEDELVDGAWKFELNTQIALFLDLLADSLNAVGPIPGELSTRLESYRARLRAPEPNGSSSTDARSSDRGHGEKSDVESVRSVRRDIEGLKGRETEGVAQLFGMTEDDLASKLKELQSICTEQAALEDLKVSKFTILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJV1</accession>
    <name>A0A1Y2AJV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_550815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJV1"/>
    <dbReference type="InParanoid" id="A0A1Y2AJV1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="513" mass="57199" checksum="297C3F5D8BFE49B2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALD6</accession>
    <name>A0A1Y2ALD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_360501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALD6"/>
    <dbReference type="FunCoup" id="A0A1Y2ALD6">
        <property type="interactions" value="650"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALD6"/>
    <dbReference type="InParanoid" id="A0A1Y2ALD6"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000005">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY23373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="515" mass="56414" checksum="E7CD190E29C5D4A5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALR7</accession>
    <name>A0A1Y2ALR7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_449630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALR7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALR7"/>
    <dbReference type="InParanoid" id="A0A1Y2ALR7"/>
    <dbReference type="OrthoDB" id="5593376at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="567" mass="62116" checksum="BA842F808A72E2E4" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM30</accession>
    <name>A0A1Y2AM30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_561926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM30"/>
    <dbReference type="STRING" id="71784.A0A1Y2AM30"/>
    <dbReference type="InParanoid" id="A0A1Y2AM30"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF42">
        <property type="entry name" value="DNA POLYMERASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="5">
        <location>
            <begin position="80"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="416" mass="46605" checksum="DE091F87E1828BB4" modified="2017-08-30" version="1">MTTHFIPIVRRAVLSGPRIASWRYKSTGGANSNRISTKKTKPRQLGFNDLDEVSTLQSNSPTFHLDQLKQEDSSGYIHRTLPTSKLLETFREMMSLRSLNPLPNAPRDHGFKPALKAVELAALDGQDSVSISEILANLSPENDIVWGVIYQLLKHGLTPEIDALNDEQRAAVLFNRVHGFGRVKAQYFANAGARTVDDLLVDPDRQWGEKARKISPAELLALQHFAEMELMVPRNEIEQLRTLIDSAFKKADPQLSFEIVGSFRRGEALSSDIDVVVWHPSYTCREAATTKSKKKLEPDSLISRVKQALCSAGLLNEHMIFSQGERKIMALTQLPNSTGSVHRQIDIRLCPTTSLPYMLLGNTGDDELMKYLRVRALEKGWVLNEYGMAKRLRGHTIPTMEEGSGIVVSSEKEIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMC0</accession>
    <name>A0A1Y2AMC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_487029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in 20S proteasome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 20S proteasome chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMC0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMC0"/>
    <dbReference type="InParanoid" id="A0A1Y2AMC0"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY23634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="278" mass="30173" checksum="DA2B7899754F2BB8" modified="2017-08-30" version="1">MVAYYPSGPSTLRNKVLIVPAVSLANLPQLAADLLITTLGLSRTGFIGRGETVIPLSGVGERGEILTGGLEVYGREDSELVVIQQRSPTLKAKKDAHLSLLSDFITSNDFAFVLILASLDASDRDDESLQHAYVTAQSPEISPELYYSTYHRYIIPPNLSSSDKASLTKRLPNLASRMTTPTAHQPYPPFLPYAGLTRRILTTLQKDTDKVPHAALAYWCSEGDNRADAHALAAEVLEVFTSAGDLKLELKEPKSWEGLFGPGEGWTGATARDAVLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMM6</accession>
    <name>A0A1Y2AMM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_472897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMM6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMM6"/>
    <dbReference type="InParanoid" id="A0A1Y2AMM6"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="10">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="86"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="9">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY23811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26748" checksum="043EC8B3D4AE706C" modified="2017-08-30" version="1" fragment="single">MPYSKLRGSESLSRVSHQSRFSCLYLPDVFPERNKLMSDHNAICNCDPESRCGENCINRAMNYLCGKECPCGDLCENKSLAKRRMVPTKVVYTGARGFGLIVQEDVKEGDFVTDYRGEVISLETFIQRIGDEYKGHRNFYALAYDQDEVIDAGMRGNDARYINHSCDPNLEVRKYQQTGDGIEEYEVGMWAIKDIPKGTELSYDYNFDSFAAATETELRTRCHCGAANCVGFLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN68</accession>
    <name>A0A1Y2AN68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_341251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN68"/>
    <dbReference type="STRING" id="71784.A0A1Y2AN68"/>
    <dbReference type="InParanoid" id="A0A1Y2AN68"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="223" mass="24706" checksum="F2C8963D389BBCA3" modified="2017-08-30" version="1">MRLTIIAPDNVYEHEVDPSMEIQDVQALIEAETGLPATAQVLSNDSGVQMTDTKRSLESYGVAGQASSIFLTLPNAQPVASTSYAPPPSQSGFPSSDSDLERMRLQALGDPRLMADLRAVRYLLLNHELELIPFILRHHLASPVVFVLICAPDSPPGSRHPHNPRIWSIHHISVLALSKLQNDPEMASAIQAGTQRFKEAFMRQQLRMRQAALEKDRQIEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP08</accession>
    <name>A0A1Y2AP08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_547326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP08"/>
    <dbReference type="FunCoup" id="A0A1Y2AP08">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AP08"/>
    <dbReference type="InParanoid" id="A0A1Y2AP08"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="208" mass="22056" checksum="8E73EBDF73418C34" modified="2017-08-30" version="1">MASAFRQIIKRGYATAAAGQKAPIQLNSLTGTYATSTYLAALKRSEKDLDTLSKDIDAFDKKIKEDPQVAAFIDNPTLSQGERQAAISSVVPKGASPILLNLLNVLSENGRLAAAPKVFADFNTLMSAYRGELEVIVTSAEPLDSKAMARLDKALKATQIAQGKTLKITNKVNPGILGGLSVDFGEKSIDLSASTKVNRYNAALAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APE7</accession>
    <name>A0A1Y2APE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_582666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APE7"/>
    <dbReference type="InParanoid" id="A0A1Y2APE7"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="549" mass="60446" checksum="193DF2C4B7685AE3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APQ1</accession>
    <name>A0A1Y2APQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_590527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APQ1"/>
    <dbReference type="STRING" id="71784.A0A1Y2APQ1"/>
    <dbReference type="InParanoid" id="A0A1Y2APQ1"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="481" mass="52762" checksum="6C8BFCFB26CFCFE1" modified="2017-08-30" version="1">MAPISLADLATGPVSPSDTVKALKSYTKHPNLLHSLPFPIAKDGKPNAVHSKGIYWYLEDGSVLMDAGSSGVAVTCIGMGIPEVFDAIDKQMRKTAFVYHAYLSCPPAAELADYLLAKSDGAFQKATFFCSGSEAIEAALKLSFNYWRNKGQPQRRHFISREYSYHGNTFGAMQLGDSARSHFYRPLWEESSTFHKVSSGGYLRDKREGETEEEFSERMSQELEAKILSLGPDTVMAFCAETVNGGIMAAVAPPKGYFPAISRVLKKYDILLVMDEVLCGMGRVGTLHAWQTVGEGVRPDIQPIAKGLGGGYMPISGVLVNHKVSEVLGEGMVHAHTYQEHPVACAAALAVQKYVFDHDLLANNRLRGAQLLTLLKEGLDHLEYVRDVRGTGCLLGIEFEPFYFNPKAKPRFAPRLSAAGRINGVLLTNLSGNQDFNYGEGCYLAPAFTLTEDETNLMAELVIKSIKDAHQSYIDDYPKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARQ3</accession>
    <name>A0A1Y2ARQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_544780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARQ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARQ3"/>
    <dbReference type="InParanoid" id="A0A1Y2ARQ3"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16341" checksum="0CC46DA802F49EC0" modified="2017-08-30" version="1">MSSSITLPADFSLVGLGVTAALLLNQWQQHLVVRARKTAGVRYPTLYATDAEAAADPKKQMYNCTQRANANTLESIPFILAEYGFLSIFYPKAALAFLGLYLLGRVSYTINYAKGEPLKRNKGLAPVSYIGLAGLMFGSAGIAVVRSLAAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS09</accession>
    <name>A0A1Y2AS09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_292376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS09"/>
    <dbReference type="InParanoid" id="A0A1Y2AS09"/>
    <dbReference type="OrthoDB" id="2536714at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="805" mass="87009" checksum="C915ACFB5DED1D5D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS16</accession>
    <name>A0A1Y2AS16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_499325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS16"/>
    <dbReference type="FunCoup" id="A0A1Y2AS16">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS16"/>
    <dbReference type="InParanoid" id="A0A1Y2AS16"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="486" mass="51753" checksum="DE9DE889C3A5D9E1" modified="2017-08-30" version="1">MRSTCCRRAAAQTIAARTSAIHPVPYSWVNPDAPGPSSGPLAGRAIAIKDNISYISSPTSCSSLILQDYNPPYSATCVESLVEAGAHITGQTKMDEFGMGSQTTHLPPHYTPVHNPASPSPGEPPRSAGGSSGGSAAAVAEGSCWAALGTDTGGSVRLPASYCGVVGLKPSYGLISRHGIVSYADSLDCVGILAKTTDITRQVFSILSHPDEKDMTCVSSSSRKLANEILDSHQSKITPTSTHPLIGIRIGLPLQTHLPAPHVQTPPSLLEHLQSLGATLHPVDIPSFKMALPAYYVLASAEASSNLGRYGGGWVGSKIGDNEGEFVGESGEERRKRIRSGRFGPEVKKRILAGTYALSADEFNNTYLKALHLRSTLRRQFNSIFRIPHPLRPSHTAPTKGIDILLHPTAFRTAPLLDSSTERGQSEYLQDLLTVPASLAGLPALSVPAGKLNDGWPVGMSLTGQWGMEDLIFRIAEGVEKWDKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASK6</accession>
    <name>A0A1Y2ASK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="12" type="ORF">BCR39DRAFT_544734</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASK6"/>
    <dbReference type="FunCoup" id="A0A1Y2ASK6">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASK6"/>
    <dbReference type="InParanoid" id="A0A1Y2ASK6"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="40"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="88"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY25280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="483" mass="52160" checksum="178833A382472914" modified="2017-08-30" version="1">MSAVGQIPASSGWTFTQGLILGQASFLVLVLLFVRYVVFSPSESIDDEGWRRRREERAKKTVLSTTAVPAPPASTLLFKTEYEMGTHPAESADWLNVLFAQVLQGYRNDLLSSGGEEGARQRVESWLNPEEGRLSWLDPIHVTALNLGSSFPLLSNARIRPADSQGRIRAEIDIDYLDSVSLSLSTAVLINFPRPRFAVLPVSLGVELVSIGGTMSVQLHEPVEEFQHLHVCLLPDFHLNLKTTTLLGSRAKLQDIPKLEQIIIARLRAVVQDRLVHPHHLTITLPRLLSPTASAKPIIADVGEAAVTAMSDAVKQGLSQMVNDFSGASFVPPQPPQSPSSGTVSSHSPHPSDLPPYVPRSPRISQRKITMPAGFPGSAPYAASSIHSTPLQTPDLAGPGQFRRPNHPPIVSGSSSAYRVPQTQGSVNLNSATPSVSGQSQSQSQSQASQFRFRGQFASQPGTPGGAVYSESEHRMGVLNARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASW7</accession>
    <name>A0A1Y2ASW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_543514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BZW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASW7"/>
    <dbReference type="InParanoid" id="A0A1Y2ASW7"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11560">
        <property type="entry name" value="W2_eIF5C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043510">
        <property type="entry name" value="W2_5MP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="3">
        <location>
            <begin position="281"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="447" mass="50117" checksum="D7B470B6EAE5B797" modified="2017-08-30" version="1">MSHTPTSTGPGGNALAPNQSAAQDKKPSLAGVRVRQRKGQAKASAKFEPESFRDSFLLHLALLPSPLTTDALVAKLVQAGTTLEYLKYNEQFFELLFVGGLLQPGGAYLDDKRSPVYIVKTDDTSVTGDEGRGEDSWKDGVKGMVEVLKRVIQRYKYLQKPLEEDFLPNLLGYLGKWDLTARAKLAEATALLILELGASPKCLQSLAKDHVVKDGVALSFLSPFFKTYLSKQNVEHLGSTLRRSGLRDLLLVFPIQTRDRAHLEEYFKKEGLQPIIDWYAKLASLEAREQTINEVGRLINDEETNEQIIEFIKNQQVEKPAPEADLCEWIWQGLMKSIDWSARPDQLDQAVILHLTARAPILEAFCNGAKAQIGLINAIQVYCYTDTRIIKAFAQIVKVLYNADVISDQAIIYWHQKGAKPQGKQHFLKATEAMVKFLEEQESDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT39</accession>
    <name>A0A1Y2AT39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_543429</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT39"/>
    <dbReference type="FunCoup" id="A0A1Y2AT39">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AT39"/>
    <dbReference type="InParanoid" id="A0A1Y2AT39"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="815"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="546"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="676"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY25634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="835" mass="94708" checksum="8CE7C7DB348B5073" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATD3</accession>
    <name>A0A1Y2ATD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_542835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATD3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATD3"/>
    <dbReference type="InParanoid" id="A0A1Y2ATD3"/>
    <dbReference type="OrthoDB" id="2564751at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="472" mass="50066" checksum="ED6D27BE92AAD5E8" modified="2017-08-30" version="1">MPSASHDYSDSEGDSPPPAPASTVSESTSVNVAGPSKSNSTVKSENHHPLRITLRPSLNHLINSSTSAPVPLSDRSSLSPPPPITLKFGMKHATSAKASYSSSSSDEEDIDGDMDVDVDVEADVDAASGHPQGKKSKSETMPAQHRKTYDWLQPGTAAASHHGPPPRLSGWTPEGGETATTPSTTVTSGVKKSSKKRPGDAPAGPGKAWRKGLKKGMAIPWKEGGTFQADGSIGYATPAGSYPLSQEGTPEPPPITEPPVPFVPADPALLDFPVYRKPIIAPKVILGNFPKVTAFFFQDNGGDSGPFPRKERVRDWKLQERVMVGVGGGQLKVKTWHMGPPSELGRLLQAEKEAKDLAKARKSITSQAERPSMPSAQPSYEGERPEDDASEIGDGEESNAGSVLASTQSSKPPKTKSTKPKQPRKSKLAQEIVALEPEPEAEVQVEVDPEPEPEADIEMEVEAEGTPGVIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATM1</accession>
    <name>A0A1Y2ATM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_470972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATM1"/>
    <dbReference type="InParanoid" id="A0A1Y2ATM1"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55279" checksum="87E09C205BD3369B" modified="2017-08-30" version="1">MVAWTYINAVGGSIISGLTVLASVYLMVSLARQGRGKLRVRLLLGMVISDLLVGLIVFPQEFSYLVKHPLTPGNACNTVGFLFTAIVFSQHLWTLSIAFATFLLLKYPLSKTTTILDRYSYFAAPIIWAISFAQSGIWWATVGWRPSGATCYYGSHLIHGSSLDARDLVQFIPRGFVFLVVVALYTRLFSFLRRPDTIQLSSPFVSGTATDGEDHRLGVGNKLLKPFQWRRQRTSIPSNGGGTVDAAAPWEQMEFVQIGGRRNIWSPTQTQNSFNHYPQMISHAEILQPTLGSPVKETKDPFVTELHREASGSDSTVVPESSGSDQPPSESETLAAPELQYAPTNIKRPSTTTTLAPVFSEERTGATGARAGRRRRPSGQTLKEFFQENQIASLDGREQRTSASHGNGTGGMQMSATAYFNRQASLLMLYFPLAYLTVFSISLVRLVYDMVNHQPSPVLALLSGWMVVSVGLIDGLVYGFAEYMVRRRVRRKMPEQFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUT7</accession>
    <name>A0A1Y2AUT7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3HC zinc finger-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_541255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUT7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUT7"/>
    <dbReference type="InParanoid" id="A0A1Y2AUT7"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="112"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="299"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY26312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="403" mass="44866" checksum="E9FA7B206CABCDA2" modified="2017-08-30" version="1">MSASPDPDLRDVFHLLYDDDDEDEAWGDFGSDGDGDGALDVDAVEADIEPDASTKYTRKRFRALIDDLFLPYSQSSKRQRIYTPPIQPVSILTPILSTSSLPLATSSAVYAPFSPYALLARLQTYTPASFPSSLSATKLARNGWICSGRETLSCGACGSSWSVKGVDEIDNEKIRLEVARRLGESANTRHRQGCAWKVRDTPDDVGPRISTLLHPMISSSLAPLAERIQHECLSEGPSLRWKSPLTDKQLARLVVRLDAYVDADESDSPTPLSHLSTSHSSPTSISRLSTTSITNLSAALALFAWYPYHSKTSTPLQIDRSVPPKRTEIVQCRICQRRVGLWAFKGDVKREMDVCAEHLAWCPVRQEGWWETAGLLKENKVEWSGGQWISLSDKLEKKSWRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUU9</accession>
    <name>A0A1Y2AUU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_541299</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUU9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUU9"/>
    <dbReference type="InParanoid" id="A0A1Y2AUU9"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="77"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY26322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="390" mass="41771" checksum="CF5133FD22C53451" modified="2017-08-30" version="1">MSTQDFKQAPHKLLVIPGPIEFSDPVLLANATPGTSHVSPAFIPVFGDCLRMLKTVLYAEQGHGNQGFLVAGSGTLGWDAVGANLIERGDKAVVLHTGYFGDSFADCLEAYGAEVTQVKAEIGDVPSDEQIVQALQSKPKLITITHVDTSTGVLSPAAHIASLVKKHSPDTLIALDAVCSVASEEIRFDDWGIDVVISATQKGLGTPPGLSVLMASGRAIKTFEERKTPVQGYYISWKKWLPIMQAYEAGKPMYFATPPVQLVYALHASLSAITKQSPSLSERFEAHKAAAKYVRSELSQLGFGFVPKSVEVSANGMTAVKYPTGVQASDILPKLAEKDIVVAAGLHKAISTQYFRIGHMGITAIDKQRGDVERVVDGIKAVIKARNEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUV6</accession>
    <name>A0A1Y2AUV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_542425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUV6"/>
    <dbReference type="InParanoid" id="A0A1Y2AUV6"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="129"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY26060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="400" mass="41630" checksum="754A3721493696B9" modified="2017-08-30" version="1">MSFLNRADESGAAPGCVWAWDVSGGISGKSPTATVSRIATVVTTSSVYTYSSSFDDLWASGSPTSELGNGRSSSTGSISTIPGGHVTSTSKGSTSHSSTVSPSASTGSGSGGGGNSSSTGSGGFQVSAPHYVVYADQSNYGYPSASQAGKWNRVVLAFWLTQGAWDNAKVWESLSASARQSQIEAYHAKNIAIMVSAFGDTEQPTTSGEDPVQLADKLAAWVLQYGLDGVDVDYEDAPAMAEGKGEAWLIAFTKELRNKLPKPHIITHAPQAPWFMQNKQAYPGGGMIAVDKAVGGLIDFYNVQFYNQGAAYGDCTGLITNSGNSFPATSIMELNKAGIPLDKIVLGKPVSASEAGTGYMDPKTLAGCVTQGKAKGWNGGVMTWQWTADATNFGNTVCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVS2</accession>
    <name>A0A1Y2AVS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_253550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVS2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVS2"/>
    <dbReference type="InParanoid" id="A0A1Y2AVS2"/>
    <dbReference type="OrthoDB" id="2559463at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="254" mass="28546" checksum="491E15E4A7223CBE" modified="2017-08-30" version="1">MIGNVPPELDQQLGLGVPFSVLDVGCGTGSWALEIALAYPNTQVTAIDLVTCPLPTYPNNLTFEIRDIVKNLPYPDNSFDVVHVCDIKLGIHDYRSLIGECSRVLKPEGWLLGLELDCDPTLMLDNAEDVPRYLKSVSEFIKIFHTALSERGLNAYVARELGDYARQVTALDHVKHVRVVVPWNDWSDDPKLKLAGRHSRLAFEEFSSSIRILLQDHGVLNPDRLGNEAKAEMDQEGIRPIWGFYHLVARKRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWE9</accession>
    <name>A0A1Y2AWE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_589529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWE9"/>
    <dbReference type="InParanoid" id="A0A1Y2AWE9"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="811"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1463"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1492"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1709" mass="184315" checksum="6A3923A5D93320A2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWS6</accession>
    <name>A0A1Y2AWS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FMN-dependent dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_540435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWS6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWS6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWS6"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="131"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="5">
        <location>
            <begin position="234"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="600" mass="65851" checksum="237B2AC7698D43C5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYA5</accession>
    <name>A0A1Y2AYA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rossman fold oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_538151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYA5"/>
    <dbReference type="InParanoid" id="A0A1Y2AYA5"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29916" checksum="D24A9087B9155B20" modified="2017-08-30" version="1">MSVAILQGSSGGLGLAVTRHILQKTRLKVYALTHSSSSDKISDGLGSLVRDGRLEVLTGVDVLEESTLERAAKTVREAEGKGSVRLIACLAGILHPEKSLSSVSAQEALSTFQINTLGHLLTYKHLVPLLPTKRALAQLKEEWEANEGDPAKGLIGASNSLCFSLSARVGSIADNERGGWYSYRASKAALNQVIRTLDHELVNKSTSAVAVGYHPGTVLTSFTRPVIGDKPADPKHGVFEVDDAVSHMTKLMSRVKRDGDQVFGGRCFDWRGERVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYY4</accession>
    <name>A0A1Y2AYY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_589050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYY4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYY4"/>
    <dbReference type="InParanoid" id="A0A1Y2AYY4"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="188" mass="20982" checksum="FDD6B44A70CA72AD" modified="2017-08-30" version="1">MATSKSPDYTIKIAESKDEIEACYDVRIEVFAVEQGFPLETEIDEYDPISVHFLLCVSQPSPPPESTSSISPFSNSTSHSSTSKAIGTIRWTPSIGKVARLAILSPYRKYGLGRKLVEALHAHAANGGQEMEKIIKYVDGKRVAQLKLHSQMQVVPWYEKFGYRAEGDTFDEEGAPHQKMTCEIEIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0A5</accession>
    <name>A0A1Y2B0A5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_594273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY27990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0A5"/>
    <dbReference type="FunCoup" id="A0A1Y2B0A5">
        <property type="interactions" value="736"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0A5"/>
    <dbReference type="InParanoid" id="A0A1Y2B0A5"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="768"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="798"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="891"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="956"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="822"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="968"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY27990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1011" mass="109491" checksum="DA3A95469A60DD13" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0C7</accession>
    <name>A0A1Y2B0C7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_205414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0C7"/>
    <dbReference type="InParanoid" id="A0A1Y2B0C7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="314" mass="35412" checksum="FFDD7CE9E6DA4519" modified="2017-08-30" version="1">MIYSSIDVWRSTTIRFLSLSKLRHISQYHSMTVFRPGTIIRRSLLLSGVVSRAGTGTYDHLEVHLDENELAPWEWRICIKSTPLPENVPCSSTFSKTEGGSDTQDHMDSATEERQFFQETGQIRCYIHSDSQSQDSWSKLRPRHIKSFFKGGAWRASQEICDLARTEVWEARQREKRRHEEEHDTTQMQGSGPSATIFGRCCSSSGKAESESYVYVIDIHNGQTTDSPKATLFEEHETRLKSMLVEQIVNQDGLTEDTDSGYYEGSLPSSGTTTPRSDTSSTGSRTPTMPSTPTRSSTPNYSPIGLHNRSPVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0D9</accession>
    <name>A0A1Y2B0D9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_535231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0D9"/>
    <dbReference type="InParanoid" id="A0A1Y2B0D9"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="506" mass="56526" checksum="3B9B972837CC1929" modified="2017-08-30" version="1">MEPVVNTSLLEATVKSSPLEPTVKSRPLATQDSSKKPLVALDDSTIRATQAAIHSGLPKLATPLANVRDPGKLVDMLKGKLVETSPQIAQFLLYKLDFWLTKRPAWVEVYCKCMCETPGDVVARFVFGGRIDMGDGQGADELEIVNAVFRVTWEGGTEVEQQAAQRGKWVLKRAIMELANKPTRIKPLDHQATPSPPRRPPRRPSSTSSYLTVPSTHTHIQTPRSPNPTEITPSSEAQTQRQQRQQQQHRRTKARLLRAEASQSESNTTDLLVQLVRTANQVRLKDPQSPHGIPSSLIEPHLGHTYLEVARQLLPDPERKPRWASMYCTYQEADLNLETPEMVVCLKYSGFAQYREGQDGVAEKGEQDELAEKGEQDERAEKGEQEGDAENGEKVAREGQAEEVERNEEVGKEGREAKADTTGNEGQNGQNGQEGQADKGDVAERERHKEQVEDSGEELKTVIVYLKFRRTKKEGEGDKSGELIWSYAGRRIQARAPEEMKSKQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0G4</accession>
    <name>A0A1Y2B0G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_207269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0G4"/>
    <dbReference type="InParanoid" id="A0A1Y2B0G4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="449" mass="50073" checksum="56A2A1081B5D0EBC" modified="2017-08-30" version="1">MESETLNKDKFPETVFSLLLGQLGSLLRKYQRPQLLSLLADEETEQEEIDRILSGELDDGEQKWIDTRLLSDSVLAKCQEEMLLDTAEARSAAADFITQYLLDDDIPKIMSLIEEDIREKIREALPEELWPQITLDSPDITPYNFFVQARDVFRASYHCSLKKLKGPPIPELSPEPPSPRPSDRLLDMELGRFSMLVDLLNDQLYSREFDPVPVGSSASRVPTEIPSSPLNNTTALAPGDLLPSSPVGSAPPPSAPTPIAGRSSRSSSSSSDSPDERDLGDRRSASPKVRNKGKQPLQERSPTPSRAPTPVQPDSCHPQSPEPDITPFNIDINIAVDQSPRRITRSRATSSTMNEDCFRCGRRGHDERTCREDTLSSGEPVIANFGVSETATNGLPPWIYYRDDRLCTRYVFNRCNQRGCPAGKHACSLCGGRHMPRECLKYLQSLNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0S1</accession>
    <name>A0A1Y2B0S1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tyrosyl-DNA phosphodiesterase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_201434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0S1"/>
    <dbReference type="FunCoup" id="A0A1Y2B0S1">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0S1"/>
    <dbReference type="InParanoid" id="A0A1Y2B0S1"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38939" checksum="CD3E15855F143536" modified="2017-08-30" version="1">MKFAWIFYKTGRLRVAISTANMVPYDWEFIENTVFIQDFLPKSPSSTSASLMGDDLRQSFVKLFTHLNISKGLKQLKTSHPAGKLIKLDHTDDFASTMSWDWSRVKVRLVMSVPGAYKGPREMDEWGLCRLGKVLDEEGWRAGKGEVAKTEYQGSSLGQYSLDWFDTFYQACCGKTAKDLFGRAKHSGWPPMKVLFPTLATVDASIAGRAGGGTMFCGKAMNGVTRHLFHDANSKRGGVLMHCKMLIAIFEPKGQSLNTSLVSYENGKDKAEDRGGGESGIGGWIYVGSHNFSSAAWGTINKKSQPPTLSIRNYEMGIVFPLRKLQDATTICQMELTLMVCSSEECQQGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0X3</accession>
    <name>A0A1Y2B0X3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_534826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0X3"/>
    <dbReference type="FunCoup" id="A0A1Y2B0X3">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0X3"/>
    <dbReference type="InParanoid" id="A0A1Y2B0X3"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="138" mass="15332" checksum="6D68192DE85E8232" modified="2017-08-30" version="1">MSDLGGPPGDDDVGLPKATVFKLIQEMLPPDIACSKEAKDVIVECCVEWVKLISTQSNTICDESSKKTISPEHVIEALRQLGFEDFIPEVEESNKEFKQSQKDRTRNQPDTAGMSQDELLAMQERLFAASQARFEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B132</accession>
    <name>A0A1Y2B132_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_535216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B132"/>
    <dbReference type="InParanoid" id="A0A1Y2B132"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="78" mass="8431" checksum="E02F95443757EFBA" modified="2017-08-30" version="1">MGGGNGAKSQQKRERNAKEAGKEPKSQLKSNAAAQSIQCDICKQTFQSTAKLPLLQQHVDARHSGKDFSTVFPKFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B150</accession>
    <name>A0A1Y2B150_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_221653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B150"/>
    <dbReference type="STRING" id="71784.A0A1Y2B150"/>
    <dbReference type="InParanoid" id="A0A1Y2B150"/>
    <dbReference type="OrthoDB" id="3250803at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="42833" checksum="6937AD7D8BD5BAD2" modified="2017-08-30" version="1">MADVSNIVASVTDSNDASPSVSPSATPSATPSAASSQPASVEPSPSASPSASPSPSPSPSPSPSASPSPSQVQSSSPPSSASSISPSASASSQASSQSSAQSSDSSSATSQSSAATLSQSSAVSSTDTSSQAPTSTTSTTSATSFGTASDTLDLTSSLPGTTVDANGNTVTAASELTVAQLTTSNGAVFTVTHIVHAPSASSLDSSASGNSSFFANAGAVAGTFVAVGLVITGGLIAFIFFMLKRRRRQRLDRDVAAAAAAAAAANSREAFDDDEPGMTQYGGYYAATTPGMDLHGQPQPQMGQYDYEDPAGGYDPYAADLVAGDRSSTATAAGMAGFGAQAAQASYVQQAGPVNGYEELEAPYNAVSTDQHQQGGAYYYDPAQSYDTGDEDAYGGYGEESQPMRHHRSGSEGSVARGDEARGLKVTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1C7</accession>
    <name>A0A1Y2B1C7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_535317</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1C7"/>
    <dbReference type="FunCoup" id="A0A1Y2B1C7">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1C7"/>
    <dbReference type="InParanoid" id="A0A1Y2B1C7"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="353"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY28287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="426" mass="46162" checksum="894D8217D3E726FF" modified="2017-08-30" version="1">MVKCAGCGVKEASRLECPNCKKLGIPGSFFCDQDCFKSNWGTHKAIHSILQAAAKAEEEKNETLPPNMRNYNFTGPLRPVYPLSEKREVPPHIARPDYADDPQGMSACEAVRERTVKILTKEEIESMRKVCRLAREVLDLVASHIKPGVTTDELDAICHQACIDRDSYPSPLNYAKFPKSICTSVNEVICHGIPDQRPLVEGDIINLDVTLYHGGFHGDLNATYPVGKVDQDSLDLMNTTKKSMEDAIAICKPGVPFRDIGNKIEEVIKPKGYGIVRRYTGHGINQRFHGLPNIVFYGGSKTPGKMEAGQVFTIEPMINAGTSNLDHWRDDWTAVTMDGSRSAQFEETILITETGAEILTRPPPTTSSSSKKKKKKSKANGGTSTPNGGSSTPNGSAGTPNGDGSATPTTEATAGVEGLVVEGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1D8</accession>
    <name>A0A1Y2B1D8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_534599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1D8"/>
    <dbReference type="FunCoup" id="A0A1Y2B1D8">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1D8"/>
    <dbReference type="InParanoid" id="A0A1Y2B1D8"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="111"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="379" mass="40852" checksum="16607C9372D9146B" modified="2017-08-30" version="1">MSKTTTQPVPGSNWAQLKPKLAASSDSASSSPKRRKTRMSGVAHFVRPAERSSSSEAGPSKPTLISISAPARVREDVVLLPSPSDAPLVNELRSMVSGHLALSEGKRAPGNYIAIDCEMVGLGPLGSESALARVSIVNYHGHTLLDTFVAPRERVTDWRTWVSGVRESDMIGAPEFEEVQKKVAELLEGRVLVGHAIANDLKALLLDHPGPMIRDTQRCKPLREKAKTKVPSLRKLVAMELGLEIQKGSHSSVTDARATMALYRLHKTQWERDLRHVTEAYRVKSEAVKGKGKRKREDKEEEREEDEAEDGEKEGERKKKAFPGGGRKGISSGLSVVVKRNGQRVEGGRKRGDGGGGGEGGGEGAGGGGNWWEAVPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1G1</accession>
    <name>A0A1Y2B1G1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_506093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1G1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1G1"/>
    <dbReference type="InParanoid" id="A0A1Y2B1G1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="522" mass="58625" checksum="2BA1B43F9FC4AE2B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1Q8</accession>
    <name>A0A1Y2B1Q8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_186061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1Q8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1Q8"/>
    <dbReference type="InParanoid" id="A0A1Y2B1Q8"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="221" mass="23371" checksum="52A88F8E404440FD" modified="2017-08-30" version="1">MHPSLPSRPSFDLVPKEEIASGAPASKKRLTEHERDKLAYMPGPDAIPALQGSNLDAVNNRKEIRMANMSAADRLRAELSGDTGDADEPEAAADKGDTPSAAADAPDISVAQENPVDPSVIETEPVLPAEPADEAVVAPADDNMNEDEGPAADEGPISASNDSRGRKRKADEDDEDDENAEDADGSDVEAPPNPEADQPVPKKKLKVNPDGTVEGYFDDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2A3</accession>
    <name>A0A1Y2B2A3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_559253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2A3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2A3"/>
    <dbReference type="InParanoid" id="A0A1Y2B2A3"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="452" mass="49110" checksum="37014B84C01E8893" modified="2017-08-30" version="1">MTTNAESPWGPSVLPNKWQRSYWQRSVGDESLLHHGREDSLPDSADVVIIGSGLSGATTAYHLLSAEARPRTVVCLEARELCSGASGRNAGHCRPDAFRGFADYAKIHGEVEARKIIASERITLDKVVQYVNEHEIECELTLRPTVDLILSKEFERYVDTSFQLAKNAGVDVQMVKRLGQDETRDYTGSPIALGSYVWPAASIHPLKLCLGVHRKNMALGGYSLYTHCPVVSVAKDCDSWLVSTVRGQIKAGKVVFATNAYTSLLLPELAKMIEPCSIHASKVAQAPSEGAPLEPTMSLRFSLDRFYSYAPQPDRSAVLGIAAQLFPNKSMDDSAPSAEVEEAIFGSILQVLPDHGYTTNAGIPVQGHGGYEYSWLGVVGMTPDRVPLVGQLPGKDGLFIIAGMGGHGMARIFHCAPTLAEVMLGGQWDPTLPAVYQPSPDRLQREFETASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2E2</accession>
    <name>A0A1Y2B2E2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_533470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2E2"/>
    <dbReference type="FunCoup" id="A0A1Y2B2E2">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2E2"/>
    <dbReference type="InParanoid" id="A0A1Y2B2E2"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="505" mass="56352" checksum="80A5B5EEB780F7EF" modified="2017-08-30" version="1">MATLSEPNGKDVQSSARQRGHSAMDFKSATTGVVAKTMRNELNRMVSNVTDPAKKKVFDAEMQSFFILFNRYLTERAKGEKLDWDKIKPPKPEQVRPYQVLPSVDPSILNKLAVLKLNGGLGTTMGCVGPKSIIEVREGMTFLDLSVRQIEHLNSEYNCNVPFILMNSFNTDEDTARIIQKYQNHNINILTFNQSRYPRVDKESLLPCPQESSSDKANWYPPGHGDIFDALTNSGLLDKLIAAGKEYIFISNVDNLGAVVDLNIMQTMVDSQAEYVMEVTDKTKADVKGGTIIDYEGKARLLEVAQVPKDHMDEFTSVRKFKIFNTNNIWCNLRAIKRIMDEDALNLEIIVNNKVTDSGQAVIQLETAIGAAIKHFDSAIGINVPRSRFLPVKSCSDLLLIKSKLYNLEHGVLTMDKTREFGGTPVVKLGDQFKKVANFEKRFKSIPNITELDHLTVAGDVWFGKGVRLAGTCIIVANEGNKIMIPDGTNLENKLVTGHVTIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2X0</accession>
    <name>A0A1Y2B2X0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADC synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_565229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2X0"/>
    <dbReference type="FunCoup" id="A0A1Y2B2X0">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2X0"/>
    <dbReference type="InParanoid" id="A0A1Y2B2X0"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="3">
        <location>
            <begin position="61"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="2">
        <location>
            <begin position="251"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="520" mass="57217" checksum="8FC89F8561DE997C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B394</accession>
    <name>A0A1Y2B394_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_588343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B394"/>
    <dbReference type="InParanoid" id="A0A1Y2B394"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="174" mass="17681" checksum="F46850056CDA4776" modified="2017-08-30" version="1">MSESEGPGTEAEPLGSGFGLTTVTGATGATGAMGSMREGARTRGGTTLPTSAGMAETPEMSLPTHSSGHTSSVHRDSLITGLSTWIFSSLNAERIFRASVIAGGAYTGFRFASSGDSPFDYIAGTIKGGAAGDVLRRGVEHAYRSFMRGGQIQSSADRTAGQTIRGSAVPGSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3D3</accession>
    <name>A0A1Y2B3D3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_533454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3D3"/>
    <dbReference type="FunCoup" id="A0A1Y2B3D3">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2B3D3"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="825" mass="89231" checksum="C1FDA08A4BFEABD8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B414</accession>
    <name>A0A1Y2B414_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_532135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B414"/>
    <dbReference type="FunCoup" id="A0A1Y2B414">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B414"/>
    <dbReference type="InParanoid" id="A0A1Y2B414"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="206" mass="22341" checksum="B63EA016FFA17A0E" modified="2017-08-30" version="1">MAMEDVLPALLVIGLVWVLIRYMSRSSNTSTLNRDGIIGVTPAMVETVHSAFPHIPPGNIIYSLSKTRSAQATSEEIIERGFLPIPPATFNIPASLLPPSVNPPTPTSPTKPTLPSRPVPSLIERYQLSSRIPSRKGKEKDEEDSGAGAPGAAPGGGVGGEAVKWEDTREGREKGLKERKERMILEARRRLLEKQASATEQQTTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B462</accession>
    <name>A0A1Y2B462_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Yos1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_532408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B462"/>
    <dbReference type="FunCoup" id="A0A1Y2B462">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B462"/>
    <dbReference type="InParanoid" id="A0A1Y2B462"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="108" mass="11535" checksum="7CD4FE64FF5207C0" modified="2017-08-30" version="1">MVFNYFGHILYIGLLLTNAIAILNEERFLAKIGWSTRSPTSVNQGFGHAQNPNIYGDAFGSTSGVGAGDGGLSIKSKLVNLIGATRTLMRLPLIVVNVLVILYELALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4C1</accession>
    <name>A0A1Y2B4C1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_168141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Laccase that catalyzes the oxidation of certain aromatic compounds, including L-dopa, to quinones, which then polymerize to melanin. Able to oxidize a wide variety of aromatic diphenol and diamino groups in the ortho, meta, and para positions but not monophenolic groups such as in phenol, tyramine, or tyrosine. Plays an important role in virulence. Plays a role in dissemination to extrapulmonary sites but is not involved in pulmonary growth or in elicitation of cellular immune responses in the lung.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4C1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4C1"/>
    <dbReference type="InParanoid" id="A0A1Y2B4C1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="27"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="308"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00055106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="428" mass="45953" checksum="3FCCFAFE3155FD91" modified="2017-08-30" version="1">MADGLIGAIVVHSNHDLLQKGVDFDDEIVLLIQDWMDVQSSDLITALASPEGWNGTPAPPQGDAILINGLGQTNCSNEDIQVQTTCLLPTPPEIQVVKGRKTRLRVINSGTYGLLRLSIDQHAFTVIEADDTPVHGPSGVHEICITVGQRYSIVIDADQGKAGDGFWIRVNSAPECLVGGGHVQTGLAVLRYVDEDGSSPSKAQPDTYAWNDLAGADGPCEDFDMQVSLVPRSGENAPTEVLQRHILSSQLGAFVDVNGKTFFGYGINNVSFESQMSNPLLLQLIQGKTLDDRYQASAIFDSIGGGDIVINNLDATSSHPFHLHGRSFWIVARGRGALGPDDGGVGVNTTAPLRRDTIEIPGDSYAILRIISDVSGVWPLHCHIGYHLAIGKMSAIVVNPPAIQEFTQPDKWKKLCSLYKGPAVVHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4L9</accession>
    <name>A0A1Y2B4L9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_574548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4L9"/>
    <dbReference type="InParanoid" id="A0A1Y2B4L9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="182" mass="19530" checksum="06E330DB439DFFEB" modified="2017-08-30" version="1">MPSSATKSAATSASTRTATIGTHTVATGARTRTVATGPSTAMVATGASALTVATDTSGRDVATGTCTRTVVLGREGCREFRVASYLKERKIQADKVMSAKAGRRSVPYLMLVSPDTCARYHTTIQYTELGPKFDEFPDELFDEVTSYITVIERQWSNGLPMLSRYRFTGDGFHPNAVQSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B583</accession>
    <name>A0A1Y2B583_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_466943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B583"/>
    <dbReference type="STRING" id="71784.A0A1Y2B583"/>
    <dbReference type="InParanoid" id="A0A1Y2B583"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="678" mass="75323" checksum="6DD403C94CC786B6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5A1</accession>
    <name>A0A1Y2B5A1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_495010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5A1"/>
    <dbReference type="FunCoup" id="A0A1Y2B5A1">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5A1"/>
    <dbReference type="InParanoid" id="A0A1Y2B5A1"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="693"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY30012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="747" mass="83569" checksum="B7A2EACFC45631E3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5J8</accession>
    <name>A0A1Y2B5J8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl transferase component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5J8"/>
    <dbReference type="FunCoup" id="A0A1Y2B5J8">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5J8"/>
    <dbReference type="InParanoid" id="A0A1Y2B5J8"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="543" mass="61519" checksum="4DA14A04AA03116F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B627</accession>
    <name>A0A1Y2B627_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">53 kDa brg1-associated factor b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_494975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B627"/>
    <dbReference type="FunCoup" id="A0A1Y2B627">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B627"/>
    <dbReference type="InParanoid" id="A0A1Y2B627"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000242">
        <property type="entry name" value="53 kDa brg1-associated factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="463" mass="50992" checksum="F1BB97F15E0FE39A" modified="2017-08-30" version="1">MVYNGDEVSALVVDFGSHTTRAGYAGEDTPRVVCPSFYGYVDEPDASASGTNGEDVPMDGAAETNGGGSVKRKGRKYFVGENGPGLWRAGMEVDNFMVDGVVHDPEPASHLLHHVLHERLGVDPTEHPLMITEPAWNTQKAREALAQMAFEGEKVPAMYLGSAGVLSSFAAGKPTALVLDVGYANSSAVPVVDGYALRAGTMRQPLGSALLVNQLHHHFTNPTPSRAFPLSLTPRQLIAKRDPADSVQPKPLLREDRAPHTTASWRLWAEQFQVVDSWKEACGEIVNTRGFDFASAKELPQTLYEFPDGYHQYFGEERYRFTEMLFDPKNYFNQTIEPPAVLRTVVSGPHSHSLKDLVPLHQLVHDSIMACDVDVRAALLQNIVVVGNTSLTRGLCERLDFELAGLLPGQKIKIHSPTIPFERKYSSWLGGSVLASLGTFHQLWVTKDEYEEHGMSIVNQRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B756</accession>
    <name>A0A1Y2B756_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_529480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B756"/>
    <dbReference type="FunCoup" id="A0A1Y2B756">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B756"/>
    <dbReference type="InParanoid" id="A0A1Y2B756"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="70"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="279" mass="31189" checksum="DC585AAE0D9A4910" modified="2017-08-30" version="1">MTIRGPLWVYQPLLARYLYRRDFVTSTTTTTTTAFTRSSLNDIRHKLKPELTVHPSDLPGHTISISGRGPREAAVLIPLMNIDARPHILMEVRASELRTHAGEVSFPGGKVDSTDTSLTQAALREAFEELALPTDRVEILGMLDCPEYSLGNKARVWPIVGFLHSQSPATTTSILPSGNLASLQIRELVASPDEVSAILPLPLSALTDPARQSLHFFRMDSRKPYFKIKVDDLVHQPSSDRISQQQQDLEIWGLSGWFLNRLAWKLGWMDQPAIPDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B781</accession>
    <name>A0A1Y2B781_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_480763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B781"/>
    <dbReference type="STRING" id="71784.A0A1Y2B781"/>
    <dbReference type="InParanoid" id="A0A1Y2B781"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF23">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="6">
        <location>
            <begin position="266"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="528" mass="58528" checksum="96E5C8730F6B250C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B799</accession>
    <name>A0A1Y2B799_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_529130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B799"/>
    <dbReference type="InParanoid" id="A0A1Y2B799"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2287" mass="251309" checksum="4CA8BCEF1DC48F40" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B868</accession>
    <name>A0A1Y2B868_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_100959</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B868"/>
    <dbReference type="FunCoup" id="A0A1Y2B868">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B868"/>
    <dbReference type="InParanoid" id="A0A1Y2B868"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.480:FF:000002">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="12">
        <location>
            <begin position="67"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY31003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="338" mass="37226" checksum="4886C9373B0F6819" modified="2017-08-30" version="1">MPKATTQVFRPHAASIRPGSTSTKSGEKHGESSSSAGGGGGGGSSGARNHLFNTERFGQHILTNPLVAQGIVDKANLKQTDIVLEVGPGTGNLTVRILSVVRKCVAVEMDPRMAAEVQKRVLGKPEQKKLELIIGDFVKADLPYFDVCISNTPYQISSPLVFKLLSHRPIIRTAVLMFQREFALRLTAAPGSKSWCRLAANVQLYARVEHLMKVGKGNFRPPPQVESSVVRISPRDPPPPVRFEEFDGLNRIIFSRMNKTVRACFGAKGVKDMLERNYRTWCAEQEQGLIVPDEFDMKIKVEEIIVESGFADSRAAKMDVDDLLKLLATFNVQGVHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B926</accession>
    <name>A0A1Y2B926_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_527694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B926"/>
    <dbReference type="FunCoup" id="A0A1Y2B926">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B926"/>
    <dbReference type="InParanoid" id="A0A1Y2B926"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY31010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="355" mass="38369" checksum="B9C04854353384F8" modified="2017-08-30" version="1">MEANGSILTNKYSEGLPGARYYGGNEHIDILENLARERALKAFNLDPKVWGVNVQPYSGSTANFAAFTALIQPQDRIMGLGLPDGGHLTHGYYTAKKKITASSIYFQSFPYRVDPSTGIIDYAQLETNANLFKPRLVVCGGSAYPRDWDYARLRKIADGQGAYLLSDMAHISGLVAAGEQSSPFEYCDVVTTTTHKTLRGPRAGLIFFRKDKESDIEARVNAAVFPACQGGPHNNTIAGIAVALKQAADPAFKTYAKQVRANAAAMASVLVKHGYRLQTDGTENHLILWDLRPLGLTGSKVEKICDAAHITLNKNAVAGDTSALVPGGVRVGASALTSRSMVEKDVEVRLDCLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B954</accession>
    <name>A0A1Y2B954_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_526354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B954"/>
    <dbReference type="STRING" id="71784.A0A1Y2B954"/>
    <dbReference type="InParanoid" id="A0A1Y2B954"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY31378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="602" mass="66406" checksum="71061ADBAA40D92F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9Q7</accession>
    <name>A0A1Y2B9Q7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_525871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9Q7"/>
    <dbReference type="FunCoup" id="A0A1Y2B9Q7">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9Q7"/>
    <dbReference type="InParanoid" id="A0A1Y2B9Q7"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="449" mass="50549" checksum="164F37F5C37D0356" modified="2017-08-30" version="1">MYFLTSGIHGTIYIQRPEEEEEESSSSCSEAIPSSSTITDPGVFHSFDSSGPTTQVTLKNERQVSCRDWKAWRAVKIVHAHHSGQTADRYPHNIRTEVDILRRAEHPNIIRFCVYRYISAYEQWSLSLPLLSFPLSSLLHDPNRLTLATMTHLIKSIIYQLLQALNYLHTILGVAHRDLKPENIMLDWDGTVKVIDFGTACWLSQFEHDTESSVGTGAYRAPELLFGQHEYDRRAIDLWALGAIISEFFAPIAHSARHYQGTDSDSWNSEESDGSGSSPTRSIDPLDGARDRVDEGHTQRATLFDVSFGDVGLAASVFRVRGSPSADTWPGFTSLPDANKIHFDDFPGQSFRDLLPDLQRLGSDAPHMETMLDGFLQLDPERRLSASDALNGVLWNDSILVPTGYEDLVQGRRDTVLVTRLDEKCLADLLAPWIVEAEEGYERRISEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9R3</accession>
    <name>A0A1Y2B9R3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_94863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9R3"/>
    <dbReference type="FunCoup" id="A0A1Y2B9R3">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9R3"/>
    <dbReference type="InParanoid" id="A0A1Y2B9R3"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY31217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="382" mass="41867" checksum="4FB5E8A4C652C4EB" modified="2017-08-30" version="1">MSSPPFVSSRSPPPLQHPKPTHPAYPPPEPPRTPGGSTNSSPYSQAQRISQDGYMRFSSPPVDVGANSLDSTASSSGVNPYAAPQVQSRQGYVASPNPPAPGVQGYQNLGGGFQAWPGMNDATAQMGVQFGKSAVAAGSDYVEKNVSHLWREHESDWQFTRYLPLQLIKTSFSVTNFYVFNKLRLVLFPWRHKPWSRQPKRSSENGSVEGWQAPRDDINAPDLYIPTMALVTYTLLSALVSGLQSRFHPEVLGVTLSKAMAVVITEFCIIKLGCYLLDVRGGGASGVELIGYGGYKFVGIIVTILVGFLRLGTLTSATTFIYTFSANAFFLLRSLKYVLLPDPSNMSAATQSLSHSQRSRRVQFLFFMAVSQVLWMGWLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9W4</accession>
    <name>A0A1Y2B9W4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_526085</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <sequence length="640" mass="69336" checksum="4805D5BD7F601943" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAA6</accession>
    <name>A0A1Y2BAA6_9TREE</name>
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        <submittedName>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y2BAC5_9TREE</name>
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        </submittedName>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
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                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
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                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Trs120_TRAPPC9"/>
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        <property type="entry name" value="Trs120_TRAPPC9_N"/>
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        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="125"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="581"/>
            <end position="867"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="893" mass="95179" checksum="3FB250F0D7B28AAF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAJ3</accession>
    <name>A0A1Y2BAJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_525630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAJ3"/>
    <dbReference type="FunCoup" id="A0A1Y2BAJ3">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAJ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAJ3"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000012">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="431"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY31833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="794" mass="90929" checksum="E7AC016946E25BDD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB76</accession>
    <name>A0A1Y2BB76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB76"/>
    <dbReference type="InParanoid" id="A0A1Y2BB76"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="363" mass="38883" checksum="23194C891D5306F1" modified="2017-08-30" version="1">MSHQSHPHSSNTPLSSSGTPFTSGGQSTPSAGVGSSEGFASHSPGPAEHPAAPPYRGTIRAEISLIDEQSTDEPVEVTSLTQEAEEITLRDMRCSAAAMGGGTTPLELSGYFNRIEGLIQESGRRPQLLQECQDMNESFYTHLHAVVSNTPTREMAEKVFWTSTAHSILQMSAGGRLDKSVASQVEYIARNPGTTDQHLQVMNSIMWSRDRRLEAEQVQAFLTAAIASVVACSSPTGTSEDSDPAPPYTASIGAQQTSISAGNPSVTSSSVPPRRRRRNDTTFDDGLRGIFNNTNTLRRNTNSGLRRRSNNRNGPQAPSSAESQTTTSRAPVWESDETTVSGLRRSPDQGPPPTNSQLPDSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB97</accession>
    <name>A0A1Y2BB97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB97"/>
    <dbReference type="InParanoid" id="A0A1Y2BB97"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="457" mass="50625" checksum="17FD51716585E7C1" modified="2017-08-30" version="1">MSYDETVGHYRPGSRYTSYLVAPHSVNEQLPKQPSSTASNVTNSHNRSAEIMSRHNDPYSMSTLPGTSQNDLALPPYSLVDQSMPPAGSVPTPVSGHPVAPIARGTDRNPSTQVSSYRTIGSDYQSPEMSTGRPASITRPRESQSGWSSLDSASLARQWRESQMDRRPAQPSALRPNIQVRRTRLPSCPPVSLGPRNDLLERRIGTTRRRFSHGDQSISTFPGGLTSTRARIEALERHMAPTSLSPRETVGRRDTRLPRINSSDSEFGSSVDISLASSSVHRLRISDTTRTKPSYPFTPVEASMANAPTTPHEVTQVESASTGSLNKPLPIRPNCNIEIPTYSEHSGLCSICTSTLPTYDESQLLLAGSQQRCPCRLLELFPPDEQLEILDELTNEIPAIALQIQEYRLILCTLSPEGDRDAFDQIVESIKELERRRDSCEKYVNAFQGLMRVLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBH1</accession>
    <name>A0A1Y2BBH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_479396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBH1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBH1"/>
    <dbReference type="InParanoid" id="A0A1Y2BBH1"/>
    <dbReference type="OrthoDB" id="10057598at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01236">
        <property type="entry name" value="Haem_oxygenase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="818" mass="91340" checksum="2EA4E9EA8C625B21" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBJ9</accession>
    <name>A0A1Y2BBJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_524607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBJ9"/>
    <dbReference type="FunCoup" id="A0A1Y2BBJ9">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBJ9"/>
    <dbReference type="InParanoid" id="A0A1Y2BBJ9"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF9">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="558"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="653" mass="72102" checksum="FA53B7C6B9BCDCE4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC77</accession>
    <name>A0A1Y2BC77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC77"/>
    <dbReference type="STRING" id="71784.A0A1Y2BC77"/>
    <dbReference type="InParanoid" id="A0A1Y2BC77"/>
    <dbReference type="OrthoDB" id="2153847at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013186403" evidence="1">
        <location>
            <begin position="24"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="560" mass="55446" checksum="F59256865946A8EF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCK2</accession>
    <name>A0A1Y2BCK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_525513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCK2"/>
    <dbReference type="FunCoup" id="A0A1Y2BCK2">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCK2"/>
    <dbReference type="InParanoid" id="A0A1Y2BCK2"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="54"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="165" mass="17589" checksum="46B7F5A184DEE9D5" modified="2017-08-30" version="1">MFSVARALVRPATSALRSSSRVQPAALRFSAVRFLTTRYTVDHEWVQLDPATNIGTVGITDYAQKALGDVVFVELPEAGSEVAQGDPIGAVESVKAASDIFAPVSGIVEEINETLSESPSLLNKSPQKDGWLAKIQLSSPAEFEALLSDEAYKAHCEGSEDGGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCY5</accession>
    <name>A0A1Y2BCY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_523291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCY5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCY5"/>
    <dbReference type="InParanoid" id="A0A1Y2BCY5"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="355" mass="38260" checksum="7006CD8782D74A7E" modified="2017-08-30" version="1">MSPASTYDALKLPAHVKTVLITGAGGFVGQKLAQLLLDLFPSIKVITTDIVQPPSLSDDPKRFKAVKADLGDSAQVEGLFHGEVIGGVFALHGIMSGGCEANFELGYKVNVDSHLVLLRATHAHSQKTDQRPVYVFVSSLAVYGGPKCTPTSYVVPKDTPVLAGSSYGVEKQIMELYVYDYGRKGYLDTRAVRLPTVAIRSGAPSTAASSFISGLIREPLQNQPSICPIASSLSDPILDEMPVYVSRTRTVVRNIAYAMCMPENQFKKGESRSINLPGIKVTPRQIIDALIEHGGKEKLDLVEFKKDPAVIAICQTWAGDYDSSDAQAMGFQVDDTTSGFSDAVKDFKDELAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDF7</accession>
    <name>A0A1Y2BDF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polysaccharide lyase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_564192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDF7"/>
    <dbReference type="InParanoid" id="A0A1Y2BDF7"/>
    <dbReference type="OrthoDB" id="5980780at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="entry name" value="Polysaccharide lyase family 8-like, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481:SF1">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010994231" evidence="4">
        <location>
            <begin position="19"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 8 N-terminal alpha-helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase family 8 central" evidence="5">
        <location>
            <begin position="402"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY32527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="797" mass="87600" checksum="8CECD35E315CFB1B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFB9</accession>
    <name>A0A1Y2BFB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_521546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFB9"/>
    <dbReference type="InParanoid" id="A0A1Y2BFB9"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="308"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="361"/>
            <end position="381"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="393"/>
            <end position="411"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="448"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="480"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
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            <begin position="62"/>
            <end position="518"/>
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    </feature>
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            <begin position="1"/>
            <end position="23"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="548" mass="58364" checksum="9FBFAC55262CFC63" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFV1</accession>
    <name>A0A1Y2BFV1_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">BCR39DRAFT_518613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
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        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="228"/>
        </location>
    </feature>
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            <end position="310"/>
        </location>
    </feature>
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        </location>
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            <end position="486"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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            <end position="166"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="218"/>
        </location>
    </feature>
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            <end position="228"/>
        </location>
    </feature>
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            <end position="302"/>
        </location>
    </feature>
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            <end position="358"/>
        </location>
    </feature>
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            <end position="423"/>
        </location>
    </feature>
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            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
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            <begin position="442"/>
            <end position="451"/>
        </location>
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            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
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        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
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        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1283"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1663" mass="182836" checksum="22CDCFEC6EC1FE51" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG83</accession>
    <name>A0A1Y2BG83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518886</name>
    </gene>
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        <name type="scientific">Naematelia encephala</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG83"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG83"/>
    <dbReference type="InParanoid" id="A0A1Y2BG83"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="134" mass="14396" checksum="6ACF80D04751C7A7" modified="2017-08-30" version="1">MSMFRLRPVLRQVTVRPVVSRAGMSSVHGNDPDKIAKEKARNLSGTQDSSAPHKEHAPGWNEHLASDSEAAIKADQAAPDGKPGKELQDTTVAHTHKHHHTDAGNHGAESHAAKHAPVEPTHSEDAVKADRGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGM1</accession>
    <name>A0A1Y2BGM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_230785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGM1"/>
    <dbReference type="InParanoid" id="A0A1Y2BGM1"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="409" mass="44081" checksum="6C85E3F202B9476F" modified="2017-08-30" version="1">MATTFEVVPGKSVGDFQLGDSLWHVLDLLRTQKTRYPKIEVSWDPDNAHKSAVTIHLQNITLVFPPSPHQTLQVISLPNLASTVLPVGLTLAYENDTLLSPSRPLTRARVGKILGPTYAHNGSSKLVYPGISFDISGAASGSGGAREDLVTSLTVVPREEGDIPVLNTIKGCIIQPNVGVTLFVPDELEIKINETTSQDLLLDLGPPLRKYWKEDERLERMWGAGDAEKGSCFWNYFQYGLDFLISPSGFVTKVIAHSNIPGTPLFQRYARCPWTLPTSSNNLDFSSPLSSFRAHLASKSQAQYVDEVRLTVPTIASNGHGKKKSKRVGSPSSGRSGSGGSDVSPEHGAGDGFEAVDAMVLDRVVEGGLDGVIGVGTSRLVGFDGLIVEEDQQSGGICSILVWRDDNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGP7</accession>
    <name>A0A1Y2BGP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_577703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGP7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGP7"/>
    <dbReference type="InParanoid" id="A0A1Y2BGP7"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="1">
        <location>
            <begin position="161"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="392" mass="43332" checksum="036B9641ADBAE04E" modified="2017-08-30" version="1">MSPITAIKKAGPINFGSTEGPWNHTKRLEQILGTRLNVVGLVDRDPARADRALAIKRNDDSVKAGYEKTEVFPSLAEAVVALKDKTGSEQLHLTVDGFHSTTRGSTTPNRNSDIVLAEAFPQAAHFIEKPISALESEDFQQLDEVAAALKGKITSVGYMLRYLKAVQEMKRIITENNLTIMATMATYLMAYAYAGEDTKTIGYWNKSLEMGPVVGQGTHICDLARYLAPRPLLDTIHVQTVEAADPPGHLSQIKFDVDSLVPPEQRTPRVTNAIWRWENGAVGQFLHGITLHEGDYDCELVVLADGWKLRLVDPYGVAPKLYVRQPGSKAEVQTTFTDDDCYHSEFATLIDVIDGKADRSVILSPYEDAVETYKFTWAIRLAGEADAKKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGU7</accession>
    <name>A0A1Y2BGU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_518199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGU7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGU7"/>
    <dbReference type="InParanoid" id="A0A1Y2BGU7"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19093">
        <property type="entry name" value="AKR_AtPLR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="330" mass="36685" checksum="E9023FC79EAF59F2" modified="2017-08-30" version="1">MIKRAIMTTINGKATIAGRSVPAMAIGTWSWGDKKWGYKEEDYAKVVTAWKACNSVGLTFYDTAEIYGEGESERIIGRLLREETDEETRKKIYIATKYLPYPRPANWFFFAPGVIAACRKSLARLGVDQIDLYQIHSSNGPFSIESTGKQLAKCVQLGLVKAVGVSNFNLSEMKRMSDTLEKEGVKLSSNQVEYSLLRRLPETSGLLKECKERGIALLAYSPLAMGRLTGKYSRDNPIPSNRKFSSQFTWDQIEPLLAEMKILGDKYGVSISAIALNWVIAKGAIPLGGARNSQQAEENAKATTFMLDEEEVAKLDSLGQIGKLDHWQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH42</accession>
    <name>A0A1Y2BH42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_518538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH42"/>
    <dbReference type="FunCoup" id="A0A1Y2BH42">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BH42"/>
    <dbReference type="InParanoid" id="A0A1Y2BH42"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="209"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="5">
        <location>
            <begin position="605"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="729" mass="85989" checksum="5D1E60816F9880EC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHT8</accession>
    <name>A0A1Y2BHT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_556912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHT8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHT8"/>
    <dbReference type="InParanoid" id="A0A1Y2BHT8"/>
    <dbReference type="OrthoDB" id="2572925at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="415" mass="45807" checksum="B379D56538124CD2" modified="2017-08-30" version="1">MTPIPATTDDIQPVLSSATTTPTSPLSPPLRAISPSEAVPLPLLTNPEISPSQQFTPRNENGEKQCTNCGDTDTPQWRGTLCNACALWKRSRGTDRPLPLLFPIRKRPRSPESPDSGSENQMSEGELGGNPVWAAALSPLQRPSDRGGGQARVCAFCGQAQAVMHWAGRERSNPPQHKSPSYPRTRPYMVPSPLNVRGDACVLPRASSPRSNPSDPLHPRTPLRSESNSNLQQTGLSSRSHTLPPHVQAMLQRAEADTAGHLDLRVSERRSGESNRDSDRHDSHRRAVNLPESHASAFGSAAMIKDKKLPLASDRNPQIQVDSSSRQREHSRTIGNVPRPYPGPNVAWKIDRDREFRQELGRVLGISREEFMARAKWVWNVVEGAAVALERFEMEQRLQGSLSTPRSASGEHWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI57</accession>
    <name>A0A1Y2BI57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein 70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_517280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI57"/>
    <dbReference type="FunCoup" id="A0A1Y2BI57">
        <property type="interactions" value="647"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BI57"/>
    <dbReference type="InParanoid" id="A0A1Y2BI57"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="737"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="782" mass="86437" checksum="1BB7F5925F8C717A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ37</accession>
    <name>A0A1Y2BJ37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_129885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ37"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ37"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ37"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="126"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="228"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="330" mass="35587" checksum="81C38668F28D43CC" modified="2017-08-30" version="1">MSSSTSKPFGGGRSGDRMGEKGTGKVPLSTHLIAGGTAGMAEALVCHPLDTIKVRMQLSKSRKLRGLKPLGFFATGRQIVARETPLGLYKGLGAVISGIVPKMAIRFASFETYKGWLSRDGKISSSGTFLAGLGAGATEAVAVVTPMEVIKIRLQAQQHSLADPLDIPKYRSAPHAAWTIVREEGIATLYRGVSLTALRQATNQGVNFTAYQKFKQWALDYQPQFTELPSYQTMVIGLISGAMGPFSNAPIDTIKTRIQKASHVAGETGMSRLVHVTTDLFKNEGVSAFYKGITPRVLRVAPGQAIVFTVYERVKRLIDATKTSLLDIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJJ2</accession>
    <name>A0A1Y2BJJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJJ2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJJ2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJJ2"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11538" checksum="8A1F0EF024D45324" modified="2017-08-30" version="1">MQGALGRFFNEPPQGQGSRIISARRGNSDEDRAAELSVLEKREAKYWVQQGKLSLLGNRDEEWVGMSSTKVRAAVKRGDESELKRLVSPEIAEYIQRQGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJN9</accession>
    <name>A0A1Y2BJN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RecF/RecN/SMC N terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_141044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJN9"/>
    <dbReference type="FunCoup" id="A0A1Y2BJN9">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJN9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJN9"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="9">
        <location>
            <begin position="829"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="483"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="645"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="951" mass="104429" checksum="D238B061C68CFC91" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJP4</accession>
    <name>A0A1Y2BJP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJP4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJP4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="162" mass="18120" checksum="BF09E656386AE4AF" modified="2017-08-30" version="1">MSSTVVTEDQSDPNSETEPPPDSNTAKHEPEQSSESNKASKATIGQTQTSSLAYLPLVLQTMIADEMDFETQGLYYQLAKFCAVSTYRSRFRIVSVPDQWDWNEARTEFREVLKNSVKCFVLRGTVPADQIPDLDVVTLAGARFFETGVNVSDNSKVFARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJT1</accession>
    <name>A0A1Y2BJT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_556529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJT1"/>
    <dbReference type="FunCoup" id="A0A1Y2BJT1">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJT1"/>
    <dbReference type="InParanoid" id="A0A1Y2BJT1"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="390" mass="43021" checksum="54618802EDE3E7E9" modified="2017-08-30" version="1">MPRPNDSPDVSASKTLAYILRHGAEKEQLDIRSDGYIKLADVLARPKMRGVDLEMVLRLVAENAKQRFEVFYGYDPSAPKPKVKGKGKGAGKGKGKGKKQDKSDGQTIEGASSSMEAVQLDTACVHTPTTTTRIEQDDREKLDDLESSLSSTTISNTALDAPPPPHPVITAELPLIPLPVPTDPSDPSLPPDQKGEYFIRASQGHSLKLESVSHLTPVLLDDDGRARAGEMVHGTRWELWETLKSQGLSKMARQHIHLAPTLDPSKHRITPRPTSTLYIYLDLDRLVNAGIPVYTSTNGVVLTPGDESGKVPKEFWRLVEHKVRRHVTDHEKHKLEGNGKGEGKDEQEGKDGKNGKDGKDGKEGKDIKDDDVVERVVIWRDGKDVDENRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJY7</accession>
    <name>A0A1Y2BJY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJY7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJY7"/>
    <dbReference type="InParanoid" id="A0A1Y2BJY7"/>
    <dbReference type="OrthoDB" id="2554293at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="950" mass="108392" checksum="EE35AB5683AF7CE9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKV3</accession>
    <name>A0A1Y2BKV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_5009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKV3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKV3"/>
    <dbReference type="InParanoid" id="A0A1Y2BKV3"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="541" mass="58350" checksum="3D9776B873195B87" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKX2</accession>
    <name>A0A1Y2BKX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_509565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKX2"/>
    <dbReference type="FunCoup" id="A0A1Y2BKX2">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKX2"/>
    <dbReference type="InParanoid" id="A0A1Y2BKX2"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="321" mass="37161" checksum="55A10A14E29F4B12" modified="2017-08-30" version="1">MILLESHSIIIQDVLTDRFEKPSRMDIQFVDFDHVRFHLSTGESKTQVTLSMGIHCWPDLLKYGAREHLQNEYAGMLLDPSQTEPEYDVSIVIDLEKIPSSQEERTALIHKLSLFKATAMSAPFLAAFEEESALEANYKDPAGASQIDVEQSVDAGELKIVRYREEEAMYIQARHDRVTVIFSTVFKEETDRVYGRVFLQEFVDARRLQSLQSAPQVNYSNREPPLEIRHLPGLKNGEDCGYVTFVLSKRHFANPTQAQSTILRIQLFRDYLHYHIKCSKAYMHSRMRYRVAEFLKVLNRAKPEVAVVERRTATGRTFRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLE3</accession>
    <name>A0A1Y2BLE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_510931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLE3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLE3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLE3"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="349" mass="38194" checksum="C4EAD2DBCEEA2C37" modified="2017-08-30" version="1">MSTNDRLQKGDTILVTGATGLLGASTVDALISRGFKVRGVTRDVAKTQPLKDKIEVLYGPGKIEFVQIEDATKPDAYLAALQGTTGLIHLAVDLGSVFAPDASVDSAVRSATDMTLGLLKTATKIPTIKAAVVTSSNVSIYNPEYGKDLDVSLKDYNEKSVENALAVPKDHPFRTGYIYSAAKTRSEQALWKWFSETKPRFSVNTVLPHMTIGQPFNPAEGVYSTSTWLNELFDGKLDSPIVGFLAPGSWFVDVRDCAIVHVGALLDTSTDGHRLWAAGQPPVHVNEVLKIWREAFPNHELPPDFDLPAQPKQNLDREASTQLLQRYAGRSWTPLKETLIDNVKNHIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLI6</accession>
    <name>A0A1Y2BLI6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_556484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLI6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLI6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="157" mass="17808" checksum="9F1CFFBF633B1FC3" modified="2017-08-30" version="1">MNQSLLPVWQERTLSMAHAWNEWISVKSGIGIFSLLEQAAQSEGNGIDIEIVGDRWVLGNTDRDSDLVEQAPIQLPNCFTITSNEQTWQDRPFACLTLRSYDDQSGLSSKEALAVHKSDDFDEKRKAFRTFWTGYAPSNERISFAKVAESFNISYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLS5</accession>
    <name>A0A1Y2BLS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sec20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_511217</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLS5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLS5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLS5"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="150"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY35630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="360" mass="40235" checksum="8BF1B59950AEA7BB" modified="2017-08-30" version="1">MADPVSTLAGIRRRLTDLQTFQLPRLSSCAGPLDLHRELAEEMRGDMEGVRQSIDLAREIAEGRPRSDEREEILERCDLLESELASLRISYRRGLLDSKRQIASRARSRRHELRTLSSSTIPQSEAEVIEQKNQATSRPTDMGGDDALQSKTNAVTDALRRTTTLMQAELERSVLSVQMLDQSTSTLRLTQTLYDTYTSLLTTSSRIIKSLERADAWDRALILAALILFLLCCGWVIKRRVLDRVVGGLGWWVSASGKLVGLGLGNTLSKQTRYSHRQAIPAPIPVQKEEARKHEVIGHRDSQVGKKEIKVGGILDEVVPPITLPELSDSAVVHVEESQDQPHVDIVVDDEPIIRARDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM95</accession>
    <name>A0A1Y2BM95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prephenate dehydratase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_512822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM95"/>
    <dbReference type="FunCoup" id="A0A1Y2BM95">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM95"/>
    <dbReference type="InParanoid" id="A0A1Y2BM95"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="371" mass="40210" checksum="10AACD87FD473C8B" modified="2017-08-30" version="1">MQAESESSSHARRRVESGQNDTTAQVIAYLGPQGTYGHQVAKRYLSLLPYEIASATRLESCPTISSVLTHRTATHKIVPLENSIHGSVTETLDTLLSSSLSSSSHPSSSSSSSSFPTPPQSSSSNTSKSIGDTLIIGEITLRIQHVLVARKGVSLSDIRWVRSHEQALGQCKRFLNSRIPHAKTQKWASTAGAALSLLDDNENDDLQLEREEGAAICSRAALDEVDGLDIIAEDIQDEPNNYTRFLVLSRHHSISDIHIPQDHHTSPTSFWALETLSDLTCNQTPSSSGPSISIPPLVAVYARPAPPDPTSPNERTPKWFLVEYNGAIKPAPDTKGVYLGVSSWHVQVGDKVQQNGTEKTDADVALVNNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEL8</accession>
    <name>A0A1Y2AEL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_488613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000120">
        <property type="protein sequence ID" value="ORY21001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEL8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEL8"/>
    <dbReference type="InParanoid" id="A0A1Y2AEL8"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY21001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="504" mass="54601" checksum="72448E61A9C1A03F" modified="2017-08-30" version="1">MPTHAKLRVFSLGEVEVPVGIFINNEWVEASSSETFSTTNPATGEKSLDFAHASKEDVDKAVKAARKAFKTTWGNNIQATKRAAVLFKLADLMERDTERLAALESITTGKGIRMVRTTELADSIACLRYYAGLADKLHGQTITSFGKEKFVYTVHQPIGVCGQIIPWNDPIMMWAWKVAPALAAGCTLVLKPSELTPLTALLMCDLAKEAGIPAGVLNTLPGFGSTTGDAIARHMNIDKVAFTGSVVTGRRISIAAAESNLKKVNLELGGKSPILVFDSADVEEAANWTALAIWFNSGQYCCAGSRVYIQEGVYEKFITALKQRAEACAIGQPHDEKTSFGPLICETQRDKVLNYIVSGKEAGARVVTGGEKWPQSNGGFWIEPTILADTTPDMRVVKEEIFGPVIVAAPFSTEEQAVELANDTTYGLAAAVFTNDTRQVARVTSALDAGTVWCNQYAFVHPSVPFGGFKQSGTGPELGTYGMEAYMQVKAVHQNLTQRMKWPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFT5</accession>
    <name>A0A1Y2AFT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative heat shock protein HSP60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_488345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFT5"/>
    <dbReference type="FunCoup" id="A0A1Y2AFT5">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFT5"/>
    <dbReference type="InParanoid" id="A0A1Y2AFT5"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY21478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="601" mass="64042" checksum="01E5D7D226BE3611" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFY1</accession>
    <name>A0A1Y2AFY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_64201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000112">
        <property type="protein sequence ID" value="ORY21372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFY1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFY1"/>
    <dbReference type="InParanoid" id="A0A1Y2AFY1"/>
    <dbReference type="OrthoDB" id="2570051at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="409" mass="46226" checksum="678037FA4527CF39" modified="2017-08-30" version="1">MPFRQSSSGLGPCRRCFAHLMKQNASPSSACYSSISTASSPSNRHSSASRHYSSPLATSSSSTPKQKHLPRLQPPSEYPSGRSSIFYPPFYPAPVGQENATLRKRRIDEAERVRKYEPGRAERARRDRQWAEPSYRMRKSPMRQCIVTRQLIPREFLISLRPNISIDRLYLLPQDILLPDPVVERKPKLGLGYYVTCHKDVLSVLPEKGPHLGFFSRRPVLGTMKIPETLPSMIHSQLCQRILQESKQLSRSSNTSSMNPTINQKEMMIRYLTIEEIEKINNNHKLDEDHNIISILDLSSSPTHQQKEPHSLLPGPKRKKIPTYTLTSLLPPNIANEVITALSTMLDPTTTTPGPPKRAMVAVRSWPTPLDSDSPGHLAVPLTIALWRLACWHGYGWKEYAVSKTGQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG08</accession>
    <name>A0A1Y2AG08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_591602</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="MCFC01000112">
        <property type="protein sequence ID" value="ORY21374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG08"/>
    <dbReference type="STRING" id="71784.A0A1Y2AG08"/>
    <dbReference type="InParanoid" id="A0A1Y2AG08"/>
    <dbReference type="OrthoDB" id="2596127at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="76"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="248"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY21374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="380" mass="41540" checksum="843C6B8DABFCF8C5" modified="2017-08-30" version="1">MMAVAGPSQSASSPDRSFPNPSRLRVVDSDSSSRPVKTDAAALQASLVKRAQMQKRAERWMDRMMETTVDRPSFLKALQYLSPQQYLDTIHERHLNSLCSYPTCSNAPLAPYTPHRRFSISTTKRTIKPVQGNAEEGFCSKVCRARSAWIEKGLDEEPGWLSGKGRRVELLEELEEKGDVRLVPEGRRGVVPRKSGTGPAEKEAAPGGRRLVAPSVRSSPADVSGDVTHLSTNKTADLMANLVIHERPTPSTLPIPPSLPPDPEQDPSHPPVDQSIASSNGPVSDLRAARDTPDPRTARASTSLVSAPQKLTSTLLSASRQMGPIPQLPPDSDDDEVDLAERRWAEEESAMGLGWGAEDEETRDLFEEMRAAQELLEAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG53</accession>
    <name>A0A1Y2AG53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Non-repetitive/WGA-negative nucleoporin C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_553663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000111">
        <property type="protein sequence ID" value="ORY21434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG53"/>
    <dbReference type="FunCoup" id="A0A1Y2AG53">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AG53"/>
    <dbReference type="InParanoid" id="A0A1Y2AG53"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="73"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="821"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY21434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1200" mass="133231" checksum="4ED39ADB17E95E3A" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGG9</accession>
    <name>A0A1Y2AGG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_553244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000107">
        <property type="protein sequence ID" value="ORY21651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGG9"/>
    <dbReference type="InParanoid" id="A0A1Y2AGG9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="425" mass="48017" checksum="25911B168682C6FB" modified="2017-08-30" version="1">MSASSRRLPQTVEERMEGFRNLSVNSKRRLSPIREYNPGEPDTSAVNVWYWHTCVIDLVQNALDLNCEHLQREYGAGKRVGSVDPLYVTVPCSLWNDPPAMYELYVDRILEIVRKKSMVPQTREEIHARTNTFRLLEPTFSGSLHFGVLEGEGGRQEVLEEERRRKEILDETRRQEVLEEKRRQESLEEERRIQEALEEEKRRHKIADEKEHGRRNQDPGTGHFKPASMMSMVGNVSEDWGSLGGEMGDIGYDGGGDEGYREEAPDDGIGLGAEDDAPTPRPKRTRRFSQSPPSPSISPKSPPLTNVQGGDRSRTQTQLGPPTFTTSLASSSFTQMVKTDEKCERCLIKSIDCMWKVGRNGRRQAGGVCIGCQGDTEGCVSLLGGVIGSVYQQLNELDVSDWGFEEEKDQVIEYLTMFIALNRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH09</accession>
    <name>A0A1Y2AH09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_50898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000105">
        <property type="protein sequence ID" value="ORY21744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH09"/>
    <dbReference type="STRING" id="71784.A0A1Y2AH09"/>
    <dbReference type="InParanoid" id="A0A1Y2AH09"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY21744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="535" mass="59802" checksum="62902172EC73E3D2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIQ4</accession>
    <name>A0A1Y2AIQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_562338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIQ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AIQ4"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="58" mass="6122" checksum="5A972AA99FCC057B" modified="2017-08-30" version="1">MTVTGVTSADVATTSYVPPFKYVTSYAPAPLVTGTVTGAIPRQYQATQTMPGHTYSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ54</accession>
    <name>A0A1Y2AJ54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_551549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 9">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ54"/>
    <dbReference type="FunCoup" id="A0A1Y2AJ54">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJ54"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ54"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="188"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY22512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="451" mass="48575" checksum="C6FE11BC5541C83D" modified="2017-08-30" version="1">MSNLPSEPEFQQAVTEITTTLEPFLAKNPEYRKALEVVQIPERIIQFRVTWERDDGSLAVNRGYRVQFNSALGPYKGGLRLHPSVNLSILKFLGFEQIFKNALTGLMMGGGKGGCDFDPKGKSDNEIRKFCYAFMQELSRHIGDNTDVPAGDIGTGGREIGFMFGAYKKYRNEFSGILTGKGADWGGSFIRPEATGYGLVYYVTEMLRDLDGTDWKGKRVLISGAGNVAQYAALKVIELGGTVLSLSDSTGALIATGSEGFTPADVAAIADIKLQRKSLTALDAGSKFTWHKGARPWTLFEKADIALPSASQNELNGEEAKALIKAGVRYVAEGSNMGCTQDAIDIFEASRQTAALSGDKGSIVYYAPGKAANAGGVAVSGLEMAQNSQRLKWTPEEVDAKLKDIMITCYNTCKATGTLYSDAAIPSLVAGANIAGFIKVADAMRAQGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJA7</accession>
    <name>A0A1Y2AJA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_551744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJA7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJA7"/>
    <dbReference type="InParanoid" id="A0A1Y2AJA7"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="100"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="64004" checksum="51B4DD9DF265BA84" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJC4</accession>
    <name>A0A1Y2AJC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJC4"/>
    <dbReference type="InParanoid" id="A0A1Y2AJC4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="139" mass="14931" checksum="FDD1DF0313474297" modified="2017-08-30" version="1">MGMTSDTGDDSLDSGDEGMSFSRASSPAPELLEEYTTLMSSIIDTTSLPLYKAQEGDADSEDGAAEDKKGMTKAEKQNAKKKRRKERERAARMAQAVSDANAGQAVHTSGTVAAFRLFSSTPIRPVDYGEKAEVYDIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJN8</accession>
    <name>A0A1Y2AJN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_550862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJN8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJN8"/>
    <dbReference type="InParanoid" id="A0A1Y2AJN8"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="549"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="783"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1138"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1141"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1159"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1182"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY22761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1194" mass="130471" checksum="F6B8456F19EB1FA6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALM6</accession>
    <name>A0A1Y2ALM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chitin deacetylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_549874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALM6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALM6"/>
    <dbReference type="InParanoid" id="A0A1Y2ALM6"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="80"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY23117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="353" mass="40228" checksum="549E66C136D4F6E4" modified="2017-08-30" version="1">MADISSEECEQWLERDFYGYGPNPPNPNWPNEAKIAVNFVMNHEEGGESSVELGDQGAEAFFHDFGPPGLITPVPGERDPSTESQFEYGPRVAVWRLIRLFDKHKIPITFYAVAKSFERNLDVPKHVEANGHETCCHGYRWRSYGDCSPEEEEDHVRKAVESFRKTSPSGRVPPGWFVGRPNARSAHIVAKVYKELGLEFLYWADSYADDLPYWKPMPGNPDEGLLIMPYSFDNNDTKMWFGQYASDDAFTQHAIDTFTTIREEGLEGRPAYITVAFHSRWMGRPGRFQALRRIVEHMLQFDDVWFATREQIARHFANEHPYDPSKFKTTPTSKALNGAANGHGKAQNTTGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALS6</accession>
    <name>A0A1Y2ALS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_549089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALS6"/>
    <dbReference type="FunCoup" id="A0A1Y2ALS6">
        <property type="interactions" value="729"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALS6"/>
    <dbReference type="InParanoid" id="A0A1Y2ALS6"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY23539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="523" mass="56541" checksum="E9168A275B9E0300" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANB7</accession>
    <name>A0A1Y2ANB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Enoyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_473002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANB7"/>
    <dbReference type="FunCoup" id="A0A1Y2ANB7">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANB7"/>
    <dbReference type="InParanoid" id="A0A1Y2ANB7"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="353" mass="37858" checksum="794E1418560FF6E7" modified="2017-08-30" version="1">MSTSIPKTMKALVQEDKKKASVKEIAVPALEPNDVLVKVQYTAQQNPTDWKHAAFLSPPGAILGCDFSGTVVALGTNLAVPLKVGDKVAGSVHGGLYPDKGSNAEYLRAESDLVFKVPEGLKLDEAATYGIGWGTACQTLVHSQGQQFPPAKVAGSPWLLIYGASSSVGLFAVELAKAMGYKVVAVCSPHSYDLVKSYGADELVDYHDGDAASAEIKRITGGTLERGLDTISEGSSFKIAIGGFGDKGGRLNAILPPPDEAKAIRKDIEIVNTLMYTIFGKPFKFGPNEIPANPKDREFAVEWLRRTPELITKFGIRSNPVVLRGGLEHVTEGWQEMKDGKVSGKKLVYKIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANF3</accession>
    <name>A0A1Y2ANF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_339804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANF3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANF3"/>
    <dbReference type="InParanoid" id="A0A1Y2ANF3"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="237" mass="26532" checksum="203A95466109CFA3" modified="2017-08-30" version="1">MPQLYRFPGSPAPIDFESALLALEPELLTRILLYLSPDDLCTLSRVVPDFIGIEDDEYLRMMWFSRTLPARVGFALFSPLRGRPDPKELVRRGTLRGIAIISGVRSMGYWSSESAVRLSRIHQTLHLQHVKRTLDSALAPSHRPAAAELYRARILPLPSTSTAPRISAGAHVLAKAQEKDEVRRALLRGLVGVRTIGQAIERWGLSAFGGESERVRWAVCPGIKEKRIFWETLATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANQ7</accession>
    <name>A0A1Y2ANQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANQ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2ANQ7"/>
    <dbReference type="OrthoDB" id="2526979at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="904" mass="97797" checksum="5C7DC48B460F2D3C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APC3</accession>
    <name>A0A1Y2APC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">BCR39DRAFT_322753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APC3"/>
    <dbReference type="FunCoup" id="A0A1Y2APC3">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2APC3"/>
    <dbReference type="InParanoid" id="A0A1Y2APC3"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="138"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="280" mass="30754" checksum="7E4AA44E654A4963" modified="2017-08-30" version="1">MGKPGKAKNATGPPRGRGRGRGGSSTRGAGRGRGRGGRSGPIRSMENGVAPESLIVDGQDAESSSQASSSSGTSDDDQVAEEKEEEEEDDEEEEPVKIGVPVAMWDFDHCDPKRCSGKKLARHGLITNMRVGQRFRGVVLTPKGTKPIAPCDDEIVQMSGLAVVECSWARLDEVPFGKIKGPYERLLPFLIATNPVNYGKPWKLNCVEALAAGFYITGHEKWAEALLSKFSWGHAFWKMNGDFIKRYRTCVTHEEVSAMAETLQLEMQQDRDQRKAEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APM6</accession>
    <name>A0A1Y2APM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_472288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APM6"/>
    <dbReference type="STRING" id="71784.A0A1Y2APM6"/>
    <dbReference type="InParanoid" id="A0A1Y2APM6"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="73"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="395" mass="44015" checksum="D63F8950AB3D8B8D" modified="2017-08-30" version="1">MTFTEYTHERPLFGYELSPPDPKWPGGAKLAVTFVIEYTEGGEKSVEYGDDSSEGNTLHNELLVDISRKARDDMGESEWEYGPRAGLPRLLKMFKKYGVSGTINVVTSALEKSPYWAKSVRESGWELSCAGKRWIDYMHVDPATEAEHLSEAIKSIQDFKGEKSAPTGFCIGRRSNYSQRLYAQAAKEAGVPLLYSSDSFADELPFWLTSPLATPEEDEGLLIVPTTIDTSDVRFNVSGQGFATGADYLQYLTDTFKYMYAEGESGIGRMMVITLHPKIVGHGSRAYYLEQFVKFVTEQQGVWVAPRAEIAKHWRANFPYSPSVAHDKVTIVKNVNPYNPLSKPLDAAKQAVAPTWKQFLPPRDFTGYGLESPAGDVWPNGAKIAVSFVLNCTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APU0</accession>
    <name>A0A1Y2APU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_561544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APU0"/>
    <dbReference type="InParanoid" id="A0A1Y2APU0"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10023" checksum="7850E2E28C0B7916" modified="2017-08-30" version="1">MGAVYNGLVNPVAIDAIGWKYYLVFVVLNWVSVVVAWFLLVETKRLTLEDIAVLFDGEEAAVITSDSHKTEMDESKPNPDQHVEISKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ31</accession>
    <name>A0A1Y2AQ31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_566546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ31"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ31"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY24688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="603" mass="66963" checksum="E0EFCDF73E2E8E7D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQF9</accession>
    <name>A0A1Y2AQF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Velvet factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_315454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQF9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQF9"/>
    <dbReference type="InParanoid" id="A0A1Y2AQF9"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF15">
        <property type="entry name" value="VELVET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="5">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="187" mass="20619" checksum="63489B8022AA1332" modified="2017-08-30" version="1">MNLGEINFSDHGRTYRITPIQHPIRSSAFHNAYLSRIPLAPPLIIQLDCWGSDGQLTIPHDELPFLVCHLTLQTPSGDDATLVRSPQDEVVAMLYGTLVAAPAEMNDLTGAAGVYFAFPDVSVRYVGRFRLRASLMRITGGPPLDTCITETIGIVENSDYVAPPVTDLTRHFDSQGIIRFGLPRAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQP2</accession>
    <name>A0A1Y2AQP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_545977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQP2"/>
    <dbReference type="FunCoup" id="A0A1Y2AQP2">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQP2"/>
    <dbReference type="InParanoid" id="A0A1Y2AQP2"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000401">
        <property type="entry name" value="Related to MTD1-methylenetetrahydrofolate dehydrogenase (NAD+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="280" mass="30544" checksum="EF90F2F90EF07C06" modified="2017-08-30" version="1">MWGVKANDDSDVDGIMVYYPIYGGRQDQYLQSVVSPHKDVEGLNHQFLFNLYHNIRFINPTTLRPPPASHLPTPLPSKSTGATPSSDPTPPGTVKSVLPCTPLAIVKVLEHIGVYNSLLAYGDRARGKVITVINRSEVVGRPLAALLANDGARVLSVDVDSIVEFSKRPTTSSTPTSKYNPHHVSTPLDPSFKLEDCLKISDVVISAVPVASYKVPTSALKDGCICVNVAGEKNFEADVRERASIYVPSVGVMTIAMLQRNLLRLCTYRDVEKQLSESPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQY9</accession>
    <name>A0A1Y2AQY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactonase, 7-bladed beta-propeller-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_545501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQY9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQY9"/>
    <dbReference type="InParanoid" id="A0A1Y2AQY9"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF7">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="391" mass="42394" checksum="653F13EBD30D4DD6" modified="2017-08-30" version="1">MIFSPTRLSKSISIETLSLSRKMSTYRLLAGGYRSTISLLSFDSSNAKLHVISDSPAPSNASWLELSPSKSGVLYSLSEDDKGLALSLKFDGKDRVEITGERETNGVPAHVCVLKDGSGIIAGNYGGGSIIYFPIDSDGKLSKTSESFPLKFPFVYEGKEAPVPDRQDTPHPHQIVEGEKGTLYVPDLGNDRIWVIERQGEQGFSIKGYLQCPEGDGPRHAVISPDGKHLYVLTELSNNIIVFSLNDSTYPAHPLPDFETSILPPGAPKPFVGVMSAAELLQHPSIPGVLYASNRGEVEAKKGKKDAVEGDTIAICLLSADGLKIEEIKQVRTDCDFIRAMQISPDGQYVALAGQNGGGVEIWKITGERGDVWKLAAKEESITKITDFVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARR8</accession>
    <name>A0A1Y2ARR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_292520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARR8"/>
    <dbReference type="InParanoid" id="A0A1Y2ARR8"/>
    <dbReference type="OrthoDB" id="2596934at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="4">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="438" mass="46740" checksum="51956D97DA10CB67" modified="2017-08-30" version="1">MGSVAARSPIPRPRSRSRPSNSPLRPVGPEPLRAEEDVEKAEKKPRRRRESGLLEPLHTHNPPTILDAVSSDDVTKHADAAPTMTAVASVMRNVEPDMVVVQEVDNTIGEQEGVDGIVGRHVNDPVLPTPVYLPVAGDSALFSPSSTSAILDDDGGRGRRSRSRKSVNYKEPNLVKKMRKPADYSADDSLSGRQSMSHVDSMPTFDLPLSTFNPSTSLPGSHTSRPSRPPPAAHMAGTRRKSVLPKSGYPPPQAYLDDDDDAVEDALGMSLGLDMDDTRTSTPLPEVQGARTNARSRPSDIRPVAKKLPKDEQSVAPAPQSRPSAKPSQLGGLSRPTASSAARGASVSHRAASGGFGAQSRERDALAEMPSLNGRISGVGKGSSGKEGSKGTTAGMGFEANVKKATRRFPHYYAKKGENTSRQISSHFTFHIKGIHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARX7</accession>
    <name>A0A1Y2ARX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_545348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARX7"/>
    <dbReference type="FunCoup" id="A0A1Y2ARX7">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARX7"/>
    <dbReference type="InParanoid" id="A0A1Y2ARX7"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="194"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="414" mass="46807" checksum="294ABE4712520D29" modified="2017-08-30" version="1">MEEIGIDLKLEDPTLPAQISDKQTLLNSLPAGDEELYSTWKRLEAHKEFLELQEEYIRDETHNLRRELLRAQEEVKRIQAVPLVIGQFLEPVDERRAIVGSTTGSNYVVRILSTLDRELLKPSSSVALHRHSNALVDILPPEADSSIAMLGADEKPNVKYSDVGGLDAQKQEIREAVELPLVQMDLYRKIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPCIIFIDEVDAIATKRFDAQTGSDREVQRILLELLNQMDGFDQQTTVKVIMATNRQDTLDPALLRPGRLDRKIEFPLPSRRERRLIFQTVTSKMNLGPDVDLEDYVSRPDRLSSAEISSVCQAAGLQAVRKNRYVILPIDFEEAWKSTVKRGDDTHEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASJ1</accession>
    <name>A0A1Y2ASJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_590154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASJ1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASJ1"/>
    <dbReference type="InParanoid" id="A0A1Y2ASJ1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="53"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="553" mass="60708" checksum="0566137415BEE703" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT56</accession>
    <name>A0A1Y2AT56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_543229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT56"/>
    <dbReference type="FunCoup" id="A0A1Y2AT56">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AT56"/>
    <dbReference type="InParanoid" id="A0A1Y2AT56"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000238">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.20, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="770" mass="84464" checksum="19353F9DB0C15982" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATN1</accession>
    <name>A0A1Y2ATN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_542931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATN1"/>
    <dbReference type="FunCoup" id="A0A1Y2ATN1">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2ATN1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="511" mass="56698" checksum="C9DA3F63630B2C8D" modified="2017-08-30" version="1">MSHLNLPDEQEKGEDAFVGVLETHVDVEQARKDATLNLLAHHKVTTFDPNSPEVKKVVRKIDLHIMTMVFSVYCLQLMDKNSLSYAAIEGIKKATHLTASQYSWLGSIVYFGYLGGDIPAVYFLQKFDLVRYFSIMTIAWGIVVACQAACSSFAGLAVCRFLLGFIEVCTVPACFHITASYYTAEEQIARVSFWYTSSALAGVFGGFFAWCLYFAGSFGWRAIFILYGGLTICCGLIMLFFLDASPSVARWLSEDEKVIALERLRSTRVGSEKWGFNKEQFKEAFTDIRIYLIFALLVSTGLPNGGLTAFGPTIIQGFGFKTSQTTLLAMVPGAFETLIIPIFVLIARKITRGAAGIIAIAIGIIGTILMLTVPAHAYGARYLGYVLTLQYPICIIFVITYITSGVSGTTKKFAFNCLYQAGFAAGNIIGPQTFRGKDAPNYAPAKYTMLAFIVVSGLLLGVLEAIHYYWNKKRDAQDAEDERNGVVHPIVENEEFMDLTDFQQRHFRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU19</accession>
    <name>A0A1Y2AU19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_471360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU19"/>
    <dbReference type="InParanoid" id="A0A1Y2AU19"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="455" mass="51105" checksum="9E0B1A8441ED313A" modified="2017-08-30" version="1" fragment="single">FQIISYLLSMNKGTKWNVLKQLDMTTNQWAWNSTCWTIAAIIGEVPSNLLLKKTGVRLHFMRIVVLWSIMGACGAAAQNKSGLLVTRFLLGIFECGMYPGILSQLTYWYRRDEIAVRMIVVGGAAAFSGIFTALYAWGITYMNGVHGIAAWRWALLILSLCGVPVGAIVYFFLPTFPWEAKFLTERERAILQCRLPPAQAKRADANFDWPAIRKDLSDPLFWSFTGIQVFQGVGTYGLQFWLPSIITSFGFTTTQSSQLLNIPGAAVGLSVGIFFAWLSQRTLSIPRPVYIIGVISVTFTGFFCLAFVRNKPALYALTIIASSASSAFYAMLYPWRAQTLVGATSTAFVFSFQISAGQISGIIGRCGYLANFHHSRYAPRYTVPFMVCVGFQSLAVLSTLSAWYFSRNLEKISREETKQRRREEKEQKIEQKFEQTPAQNDDIVVEPRQLKEWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUF9</accession>
    <name>A0A1Y2AUF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short chain type dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_485418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUF9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUF9"/>
    <dbReference type="InParanoid" id="A0A1Y2AUF9"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="232" mass="24864" checksum="8A411B0C06FE432A" modified="2017-08-30" version="1">MATTPPVILILGAGPNIGQAVARTFAYHGYKVAVAARSIKAADSTDNQLNIPSDFSKTSDVINAFAQTKSRFGVPSVVIYNASAGHFTPADDPFSLSLADFSSDTNINIHSAFVAAQEAVSGFAQLPASAARTFIYTGNILNTAILPRFLVAGVGKSGAAHMIWAASAAYKERGYKFYYADERKTDGSPKFGVSGDAHANLYWELAYAKTQGPWLQTFVQGEGYKQFDHTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUQ4</accession>
    <name>A0A1Y2AUQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Initiator tRNA phosphoribosyl transferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_470459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUQ4"/>
    <dbReference type="FunCoup" id="A0A1Y2AUQ4">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AUQ4"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="403"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="452" mass="49512" checksum="7EDE2598AA790E8C" modified="2017-08-30" version="1">MSAQAKAIRKQTAQHDLFNRLHSIAADEAFVRQVAHDWYEDRFDVIANQRCGNWYCDPSTSATAYAYFKSTDGHTNNWDFNLRRSNLPFATIAADRGGVILVDSTRRGKRMPDALSKTVPVWCTVINRAVGAMDPTLYLPPSIVSPSEASQIEDRLQGWVDALKASSLPLPKLAKPLRPFFIHPATSRPPEIPEDPPYIPIICLSASRQGDVPSATRVGTRTVGFEYVSGAGDDDELWARGLTPKIFHRHKTRLLESERDELEGVVDEIVGEDGVVGIQRLELNDCVTAISPRLALDIGPPVSPAPTAPTATLHVVLLDKHPKPHLHRIPGGAVLALPSARSDGPGFSRAIDEAVQYVRSVQGVVLLCPAHRELLDKPDAPSIDRSDEARKGILPLALVLLCTTSGAKEMTKPYIASQLHTLVAQWPDGNPPRAALKRVNEYLMSPQHVHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW15</accession>
    <name>A0A1Y2AW15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_470175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW15"/>
    <dbReference type="FunCoup" id="A0A1Y2AW15">
        <property type="interactions" value="840"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AW15"/>
    <dbReference type="InParanoid" id="A0A1Y2AW15"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="587" mass="64480" checksum="145E90622C87F2FF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWC6</accession>
    <name>A0A1Y2AWC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_539991</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 12">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWC6"/>
    <dbReference type="FunCoup" id="A0A1Y2AWC6">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWC6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWC6"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="13">
        <location>
            <begin position="28"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="273"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="290"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY26893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="346" mass="35746" checksum="597127F88FF85C2D" modified="2017-08-30" version="1">MLRAAVRPLRASAFSSSSKVQQWRLASSLVFLEHKGGKLNDSSLSAVTAAKTLGDTAGIVIGSKADVDGVVGEAKKIEGLSKIYTASSDLYAHTIAEAVAPLLADFLPSKSITHLFGAHTAVGKNVFPRVGGILDTSVIADIIALESSGDIFTRPIYAGNAILKVKSSDKDKIKIVTVRTTAFDKTPIGSGDAPVEEVAEISSDSPTKYVSEELTVSSRPDLSSASRVVSGGRGLKSLENFNTVLDPLADALGAAVGASRAAVDSGYADNSLQVGQTGKVVAPELYVAVGISGAIQHLAGMKESKMIVAINKDADAPIFQVADVGLVADLFEAVPELANKVQAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWN5</accession>
    <name>A0A1Y2AWN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_539607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWN5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWN5"/>
    <dbReference type="InParanoid" id="A0A1Y2AWN5"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF5">
        <property type="entry name" value="CBM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="14"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="307" mass="33688" checksum="7807DDF48269DAC8" modified="2017-08-30" version="1">MTVDGWFSGTSDCPNTDQIHHFVGDGVNLIRVPVSWQALVCNDQTSTSLNTTYFTEVDKVVQAALAQGSYVMLVVDNHARWDGKIIGEDGPAPIYLASLWGLLAYKYVYDQNVLFGLMSQPYDVDIQTWAEVLQSCVNSIREVGATMQSIVLTGNDWGSVSEWSSGRNDPLLNIADLYTTDTSLLILDAVTFLNQDHSGNSPECVTNNVDILKTFHKWLKRNDRKALISQTGAGSSSVCIAKLYQQLEYIADNDDVLVGFAILAAGNVNSSYPLNIAPENGQDRPLFTNAIKPLLPGHVVHNLVMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX86</accession>
    <name>A0A1Y2AX86_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ loop repeat-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_538987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX86"/>
    <dbReference type="FunCoup" id="A0A1Y2AX86">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AX86"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000028">
        <property type="entry name" value="Vacuolar membrane protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="583"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="626" mass="68127" checksum="CE83C3E07C17EA1A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXR3</accession>
    <name>A0A1Y2AXR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_577632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXR3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXR3"/>
    <dbReference type="InParanoid" id="A0A1Y2AXR3"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="33"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY27379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="238" mass="27366" checksum="7F8F0A2BBA394F2D" modified="2017-08-30" version="1" fragment="single">LQPAVPTDLKPEQNQQVLSHLKNPSFVRTVRTEEVRSDDLSRLRPGMWLNDAIINTYGALLLDRAEVPGAPRSIHFFNSFFYQKLSEQGYDKGMLKRWTKRSKVDIFEKDVVLFPINLGNAHWTAAAINMKEKRIEYYDSMGDRGGARKAIFRNVREYLQKEHQDKKGSAFNLSGWEDVFNPVNNGSDCGVFSCQTLEAIARGRDLVNDGFDFGAKHMSMMRKLMVFEIAQGKLEKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYN0</accession>
    <name>A0A1Y2AYN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_589233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYN0"/>
    <dbReference type="InParanoid" id="A0A1Y2AYN0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="291" mass="30671" checksum="1FF16671EDF62B00" modified="2017-08-30" version="1">MARSGELPVLEELGVEILELEVIEGEVLEPTTVEVGELKIGVLELEALELEPLEPDALEMEEVLEMEICNGGVLVGPPITLILVGLLLADTDPSSPPAFTATPVARHCAQTSAARVISDVQAHVSAVQVLSKREKTLQLAPIVAQFVVGVETTAAMENDNVIDAELEVGAEVILELELEAEGEAKGEAKGEAEGDTEGDTEGDTEGDTEGDTEGDTEGDTEGDTEGDTEAEADEVGLASARRLLASDSALSVGLVDVFWETDDGTENVLDAFCAATNGRANRRGNRFRNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZE7</accession>
    <name>A0A1Y2AZE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_537845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZE7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZE7"/>
    <dbReference type="InParanoid" id="A0A1Y2AZE7"/>
    <dbReference type="OrthoDB" id="2572208at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="352" mass="37643" checksum="E326E6D426D90BF5" modified="2017-08-30" version="1">MSPSDNSSHTPAKRVAPISASAFAFTLNASSSKKPKPPLAPPTSFAAGTSSKLAETSIKSEPNVEAQATPRKTLFQTLDALPTPIVPRPQHRISSVFGSPSALKTPSKSKIKEENTEVARALRPVGDLRGGISVEQLGKRTGQVKEEHEGVGVSPSKHKGGLKWSGKGPLPPSMQLQRLLQSHTSSTLLFYTSTHRSLFGPASVRRMLDNSKLHPTAIEHLRTAPLVLEILSIIPGVSQNGLMAHSCVLVERAALTLVPEESSSDRSAIEAAPIVVIFESVPAESPRLGMDPRLLSTKIESGMPSRQFQAGVWAPWSEVTLPIVADVNLPSRVGQSCKALFVSRYLIAEAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZX9</accession>
    <name>A0A1Y2AZX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_594234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZX9"/>
    <dbReference type="InParanoid" id="A0A1Y2AZX9"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32475" checksum="0F51397C7773ED21" modified="2017-08-30" version="1">MISEEDIQAYKSFYESQGYVIVPSLIPASQLEPLRAAADRVTDKARAGNWTHVRTVGKQFPPWIPGEDVDVWGVQHVLHPDLGEGAFAEFYGGEDMLEVSRGLMGCKREDMQFELFNLLINPLRTSYGLSWHRDDVRASALPEEEREALAVPFHAVQWNAALYDDSCLRAVPASHRRVRTDEERKAGEEGGDMPGAVVVGLKAGETVFYNNNILHVGTYNPATKRRTLHGSYGAPPPGDMTRARNVLQHDLSYVRDPSFRDGLPENLVPMVDKLNGYYAALGGKEVGYSQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2B7</accession>
    <name>A0A1Y2B2B7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_533399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2B7"/>
    <dbReference type="FunCoup" id="A0A1Y2B2B7">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2B7"/>
    <dbReference type="InParanoid" id="A0A1Y2B2B7"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="75"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="198" mass="22312" checksum="73007427231314B6" modified="2017-08-30" version="1">MALPKILQPSLTPDELTFLAEEERIDIVPLFSMTRVRLLGGIYGPFTPPSTATVPVWLALSLKRKRKARIVPPTWLNIESLQSLLSEEKTNAESFQRLPKRFIEISKVLLDVAPDDLQSPSTLRSLLKDLREVRQAKIRLGLQSEGVMRGSYLQVTNLTPLELTELKPFLVKAMGMMQALEPKREEEGEEGLGEYSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2C4</accession>
    <name>A0A1Y2B2C4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_559271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2C4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2C4"/>
    <dbReference type="InParanoid" id="A0A1Y2B2C4"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="356" mass="39194" checksum="4B4E64D991CAB04F" modified="2017-08-30" version="1">MSNAKTVFLTGVTGYVGGTYLQQLLNSPNPPSQITCLVRSPEKVKPLDAIPTVKAVVGDHAEYDLLTELAETHDITIESAESDNQKMMDALLRGMEKRHEKGLETIFIHTSGTGELADDARGEYASEVTYTDGEARPPHVLHINSLPDTAFHRKVDLSIIEADKKGWCRSYIIFPGTIWGKGTGSLFGSGISNPYSKQIPMAVQASLDRGRAGMIGKGLNYWVHVHIDDVGSHFALVYDAALFDKGPHGELGYYLCSAGEYQLLRATIAIGEVMQKHGWSKVAEPDSFAEAELDKYFSGFAKSPGGHKYYPGTNSRAESAQAKKLGWKPEHEDVDEFYQYCRDETERIGAKGAPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2N2</accession>
    <name>A0A1Y2B2N2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock factor binding protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_533483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2N2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2N2"/>
    <dbReference type="InParanoid" id="A0A1Y2B2N2"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="134" mass="13707" checksum="FF70BAB08E0434A8" modified="2017-08-30" version="1">MSAEAGPSTAALAPSGSNIKRLSTIGKHPNQASGGNTMSPVIGANKGKSVGAGSSVSGGGAGGQVFSPVELCGFVDTMLAQLETRFEDHSEQMLARMNDMSTRIDNLENTISDLMNGDIDVPISPSPSPMVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B370</accession>
    <name>A0A1Y2B370_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_533467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B370"/>
    <dbReference type="STRING" id="71784.A0A1Y2B370"/>
    <dbReference type="InParanoid" id="A0A1Y2B370"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="120"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="678"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="789"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="589"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="895"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122388" checksum="D62EC3B79394AB09" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3E1</accession>
    <name>A0A1Y2B3E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_532414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3E1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3E1"/>
    <dbReference type="InParanoid" id="A0A1Y2B3E1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY29341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35749" checksum="4E2A3DCB8A1BC2B0" modified="2017-08-30" version="1">MPIELPQGSISAHALDILQADTNLPICTACGTQYPKSVTSCVICEDPRQFVPASGQSWSSLAELGETRTQRLTEDQEDGRIKFIHTEPGFGINQTPILIETNGGSYIWDCAAYISPHLISYLSSLRMPLKAIAISHPHFFSTSLTWSRALRVPLYLCSADKEWFQRLSDITPQDDVRWWTDEIDLGPAVKLIQCGGHFPGSSILHWDRLSESPPPLDNLPTKPTPVSGIILTADTIMVQPTQKRFTFIWSAPNMIPLDPHEVIRIYDKVKYLPFGQASSTWPGRFIRQDAKDVLRRSIEEHARACGWKWDEGNELVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B499</accession>
    <name>A0A1Y2B499_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_558993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B499"/>
    <dbReference type="STRING" id="71784.A0A1Y2B499"/>
    <dbReference type="InParanoid" id="A0A1Y2B499"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="Ribosomal_bS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY29659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22309" checksum="26DF20B056F394AF" modified="2017-08-30" version="1">MSILVGTAFRAVFRAPLGFASIRFNTTDSTASTSSLNPSTSSSNPSPSSTGTGTSTSSTRSAETNTSTPTTSTTRTSSGRIWPNIRINLPSEALELVKPSNPRTEAWWQAASNARQSGKVGNTYSGRTVPVRRATDVAKEFKNLHFLMRRAGIPRLLRNEEYYEKPSDKRNRLVSERHRRRFAALVRTKVHQVQLLKNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4B1</accession>
    <name>A0A1Y2B4B1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_167816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4B1"/>
    <dbReference type="FunCoup" id="A0A1Y2B4B1">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4B1"/>
    <dbReference type="InParanoid" id="A0A1Y2B4B1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="445" mass="48786" checksum="57C1B3AE7C481F95" modified="2017-08-30" version="1">MPISPLLSFCFPRSAPGPHKSIGYAHIRATPSIPSTLPSPTLDGRALFDMEEVSYAVYYPANPGRGSWWGGEGKVGWFPEPIGAFVAGYERFLGKQGLGWIFRGLQVGIGHLKFPAYLNAPLVAPLSQKYPIVIFSHGLAGTRNTYSQYCSAIASQGYIVLAVEHRDGSAPAVVLKPGESGEERILSYVKYPDLEWKDETQPSLEQFRTLQLDYRVKEIYETYLSFLDMLGSSKGESSVSGLSQEKKVEWLESFRDTVNIDDLSLAGHSFGGGAVLHVVQTPPPESYSKLPVIRAIALDPWLEPLPTPTAMSDPKDNLPSTLVINAPGFTEWSTHFNRLLELCQAKESNANLVTVLGGNHQSFSDFPLLNPTGPGSAIELLNVIHELTNSFLLDKFTESPLIIDKVPDRGEFQRGKDGHMAGKRGQVILHVLSESQSHNDVAPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5A5</accession>
    <name>A0A1Y2B5A5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Saccharopine dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_531539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5A5"/>
    <dbReference type="FunCoup" id="A0A1Y2B5A5">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5A5"/>
    <dbReference type="InParanoid" id="A0A1Y2B5A5"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="8">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="752" mass="82890" checksum="3BB009D3D76E772B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5L5</accession>
    <name>A0A1Y2B5L5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_530978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5L5"/>
    <dbReference type="InParanoid" id="A0A1Y2B5L5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="63" mass="6902" checksum="ED1FD379ABA63011" modified="2017-08-30" version="1">MHFQWFRNGNPFVRTNSLESALSCPSVTSTTPLSASSNMTLAETVRESRVRGYSTCTASRKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B629</accession>
    <name>A0A1Y2B629_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_532115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B629"/>
    <dbReference type="FunCoup" id="A0A1Y2B629">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B629"/>
    <dbReference type="InParanoid" id="A0A1Y2B629"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="867"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY29555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1105" mass="124902" checksum="90F7776E7A03C13B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6T9</accession>
    <name>A0A1Y2B6T9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_558675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6T9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6T9"/>
    <dbReference type="InParanoid" id="A0A1Y2B6T9"/>
    <dbReference type="OrthoDB" id="2576082at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="752" mass="79458" checksum="7C88288A66C61F5B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6V9</accession>
    <name>A0A1Y2B6V9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chitin synthase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_528990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6V9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6V9"/>
    <dbReference type="InParanoid" id="A0A1Y2B6V9"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="780"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1012"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="10">
        <location>
            <begin position="308"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY30579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1044" mass="116463" checksum="65B230A7E5A0D12D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7J5</accession>
    <name>A0A1Y2B7J5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_528470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7J5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7J5"/>
    <dbReference type="InParanoid" id="A0A1Y2B7J5"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000138">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="255"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="520"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY30811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="657" mass="70273" checksum="7FF803617B81C20D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8A5</accession>
    <name>A0A1Y2B8A5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_527506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY30984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8A5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8A5"/>
    <dbReference type="InParanoid" id="A0A1Y2B8A5"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="516" mass="55449" checksum="44A4E7A5C0798999" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8Q4</accession>
    <name>A0A1Y2B8Q4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative methylcrotonoyl-coenzyme A carboxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_95168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8Q4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8Q4"/>
    <dbReference type="InParanoid" id="A0A1Y2B8Q4"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="13">
        <location>
            <begin position="89"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="208"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="666"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY31228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="746" mass="80885" checksum="F7D25DE42BA3D454" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B953</accession>
    <name>A0A1Y2B953_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_526260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B953"/>
    <dbReference type="FunCoup" id="A0A1Y2B953">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B953"/>
    <dbReference type="InParanoid" id="A0A1Y2B953"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="127"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="366" mass="40733" checksum="05454264E20D89B8" modified="2017-08-30" version="1">MPASLRIIYTCLRYAAGAGLAGAFLLAGGLWYFQRRLIYPADMPSGSRKLVPKPSDIGLAYEDVTLQTRDGIKIKAYVIPARRQYIPVGELQSMTSKERKERGEQAMHAWAEELASGDAVEYAKSRPTVVIFHANAGNMGHRLPLARKLHAEHGCNVFMLSYRGYGMSEGHPSEHGMRIDAETALEYITTHPLLGDTKLVLYGQSIGGAVCLYAASRHPDLISGLIIENTFLSLASLIPLVLPQVPTILIPILLTEHWDASASLPLIPKTTPILFMAGKKDELVAPSQMKALKALRGDGKYTWKEFEGGHNDTCLIPQYWMEIGKWLKEEIESEEEKRDDPDEKRESVEEKSSSEDDSGWEHVEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9D0</accession>
    <name>A0A1Y2B9D0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_526817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9D0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9D0"/>
    <dbReference type="InParanoid" id="A0A1Y2B9D0"/>
    <dbReference type="OrthoDB" id="2581067at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012598539" description="Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20659" checksum="3F794EDA53DF8BD5" modified="2017-08-30" version="1">MLVALFALLLLPFSFAGTVSTIYWPISSPDTNNPWIVGQKNLLAWKTGGGSGVESFDIQLHNWNKTIMNGFIPIALRVPMERLPTGRHNYGGEIEVDLDLDMPTGEGFSLIFMNTLHGQVYTKSKPFSILASTPDNYTSPDLPTATVTATITTLPNPQQEYAVTLNGIDPDATATTTTNFAGVAGNGQARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9T4</accession>
    <name>A0A1Y2B9T4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9T4"/>
    <dbReference type="InParanoid" id="A0A1Y2B9T4"/>
    <dbReference type="OrthoDB" id="2595549at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="540" mass="59312" checksum="1995E40B675A8BF2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA93</accession>
    <name>A0A1Y2BA93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gluconate 5-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_526392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA93"/>
    <dbReference type="STRING" id="71784.A0A1Y2BA93"/>
    <dbReference type="InParanoid" id="A0A1Y2BA93"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000421">
        <property type="entry name" value="Probable NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29574" checksum="B682BCC81FA09F2A" modified="2017-08-30" version="1">MISIDYSGKIVLITGGGRGIGLGIAKAFAEAGATLIITYTSTNPAATAQAIEKQYGVKVHVYYCPAEKSDLVDEMVEEVAAEVGEIDVVIANAGVSLWRDAIDMTDAELLNIMQINLFAPMYLTRAVVRQWLKVPVSLHSSSSDRGLRDQKLHLGKKILFVSSISGIVAMTPQKQAAYNASKAGLTMLAKSLAGEWAGYGITVNAISPGYIQTDMIANPPPGEGEEWVKIWKSMTPVDRWGTAEDVANHIVLLCSDRAGSFMTGSDIVVDGGYTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAD5</accession>
    <name>A0A1Y2BAD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_80876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAD5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAD5"/>
    <dbReference type="InParanoid" id="A0A1Y2BAD5"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="914" mass="100545" checksum="4E1972E2DBEBC93C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAR2</accession>
    <name>A0A1Y2BAR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ATP-dependent protein binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_493244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAR2"/>
    <dbReference type="FunCoup" id="A0A1Y2BAR2">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAR2"/>
    <dbReference type="InParanoid" id="A0A1Y2BAR2"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000016">
        <property type="entry name" value="Polyubiquitin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="381" mass="42760" checksum="828544FE217D2F0D" modified="2017-08-30" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAZ5</accession>
    <name>A0A1Y2BAZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_557942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY32018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAZ5"/>
    <dbReference type="FunCoup" id="A0A1Y2BAZ5">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAZ5"/>
    <dbReference type="InParanoid" id="A0A1Y2BAZ5"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="87"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY32018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="553" mass="61241" checksum="F49FBE884979458C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB48</accession>
    <name>A0A1Y2BB48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_79135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB48"/>
    <dbReference type="STRING" id="71784.A0A1Y2BB48"/>
    <dbReference type="InParanoid" id="A0A1Y2BB48"/>
    <dbReference type="OrthoDB" id="10673349at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="394" mass="43943" checksum="E803BD8CA40D662E" modified="2017-08-30" version="1">MSRALSDGQVVEAILYLVDEDPRPNLLFGAPAFSISQIANQLSVPIHSLNPNQLCDVIRPLCDSLFATPRVPCIRTRERGGQIRHWLVFEDFTLDKPSNYPRPQARPAAGMMLGGERRLREDVANFREKRRNRSATIVQDSPSTARFDQWHSTDPKQRDDQALQYRGAVEIEESTFDLVDMYQDGFDEAEGGKIGRGPEGEESGPRVVRFQDEIIEFSRKHPNSMTKEKPSNERPATLWEMGSLIPESTEQQYHTSQPLDITLSIPFDENDESMRSTGMEPTPLKNTVTINQPLSDSRLSPSAALSGISSLSVNENDVIHSQVDATAVVLEGASEERHHQPPTPWVTKTFADLPFGPEIAVGSSIDMISRQWQVLVAQLVVVLGLTYLIQVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCG4</accession>
    <name>A0A1Y2BCG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_459029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCG4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCG4"/>
    <dbReference type="InParanoid" id="A0A1Y2BCG4"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7396" checksum="1BB9D9AFB3545B34" modified="2017-08-30" version="1" fragment="single">ADKFVKGGFKAKMDRNEAMQVLGLRDPITSTRLKDAHRRLMLANHPDRGGSPYLAGKVNEARVFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCX3</accession>
    <name>A0A1Y2BCX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_524682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCX3"/>
    <dbReference type="FunCoup" id="A0A1Y2BCX3">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCX3"/>
    <dbReference type="InParanoid" id="A0A1Y2BCX3"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="148"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY31935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="499" mass="54405" checksum="7EAAE446411059E6" modified="2017-08-30" version="1">MSPIRSASKRGIPASSPSLTPPPDLQSKAAKKPRASKVKVSPAGKKVNDQAKTNGTVATDDIKRDDDDLPPSRPTKKPRGQGKLWPPTELDPSDHPSRAGYPIYNLPPLQVPRNGGIGPIDDVGNSKRPHLLGAHVSIGGGPATALLRASKAGANGLAMFVKSQRQWKSNPYEAEAVQRFLDLSTSKDLGGLGYPKESILVHGSYLINLGNPDKEKWETSYQCFKDDIFRCHQLGIGLYNWHPGSTVGMCTKEESYASIAKAINRVHGEVPEVICVIENMANANSNIIGTTFHDLASIIALVTDRSRVRICLDTCHLFAAGYDIRTPETYRETFRKFNEEVGNGYLAGVHLNDSKADLGGCKDLHENIGLGKIGLSAFRMIMRDPLFSGIPLVLETPAPEKALESGELSVWTSEIKLLYEIQGINDEEWVTREGEIEKRWRAERDKLNPPKEKKVKGKKSDEDGNGKKGKGGGGGGRGKGKKVKKEEDDEESGCESHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDC6</accession>
    <name>A0A1Y2BDC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_521892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDC6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDC6"/>
    <dbReference type="InParanoid" id="A0A1Y2BDC6"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="42622" checksum="E8FC4DC908C76F0D" modified="2017-08-30" version="1">MAAWVSQIQCTTAADVIMAVRYHTYPPGPTFIPSIDIALSEARPHPGGSTLQRGDLLELVGSSGSGKTTLMSFLLLVHLLPASLTIPLPPPHTSGNATVEVPLGGKGGHAAFLCPSTHRTPLPSLARAMNGHIITCVRSALTENLRSHHLTNAILEEINITIRASLSRLTIKRVKPRWRAWTLALRSVRQPPSLQLDPDSSGDVELGLVLCDGLGDSFWVEKWSEEDRRLNRRGPAGLRGGDDVGMGDVMEEVEGLRSQLGSTVIISTQGLFQGKGTSGYKAHLPPPFPSPFTAPRQDTATNFPVLPQATLWPSQWPLNVQITCKGRTTGLQYPVDLTLIDALRSNGLVAHDASPRSGQRFEAVIRVLGGAGLSGTIAGVRCGFRIGKEGMEVWGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDS5</accession>
    <name>A0A1Y2BDS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_522195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BDS5"/>
    <dbReference type="InParanoid" id="A0A1Y2BDS5"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="221"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="568" mass="61147" checksum="CD9182AAAC567C62" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDV0</accession>
    <name>A0A1Y2BDV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_504009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDV0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDV0"/>
    <dbReference type="InParanoid" id="A0A1Y2BDV0"/>
    <dbReference type="OrthoDB" id="2129662at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1240" mass="135267" checksum="79BB774EFEFD1A7F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDZ0</accession>
    <name>A0A1Y2BDZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Golgi to vacuole transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_520824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDZ0"/>
    <dbReference type="FunCoup" id="A0A1Y2BDZ0">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDZ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BDZ0"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="203" mass="22063" checksum="B69A75CF729FA2ED" modified="2017-08-30" version="1">MIQAVLIFNTHGKPRLSKFYTQSPPLMQQSLIAQIFSLISDRPAGVCNFLDAPDLVFPSSAGKGKEVRGDDDDIRVIYRHYATLYFVFVVDGAESELGILDLIQVFVESLDRAFENVCELDLIFHFDEVHHVLSEIIQGGLVLETNINEISACVQASARNRKASAASSNPLLPSMLTAPGAGRSGSRGGSADGPRRWLAAMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDZ1</accession>
    <name>A0A1Y2BDZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDZ1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDZ1"/>
    <dbReference type="InParanoid" id="A0A1Y2BDZ1"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="360" mass="40392" checksum="C328D5435A53E13D" modified="2017-08-30" version="1">MRRLADVDQQWYFSRDALDHTPSRQDGMSLDVELQRRKEVIENIRSLAFRVKLADEEIDPTSIRARPVITSAATLVHRFYMRRSFADFEARLIAPTALFLASKIEDEQVKLRHIVNSCLDKWERGATPWHPEDERSPYAQQSREHQRWERDIIAVEEIMLDTLCFDMSIPQSYSILREATLGLGEMAAETSARAVAGGVTNGHGKRKSMIDEQMVATTGWVIILQSHFPPLPVLCLPNVLAFTVFAFLVSLLDQISWSEALAAASELGDRFGLDVHFDAEQGAVGANDLKLVQECRQLFIGYMTSFIDASLMTVLPNDSTVPSHYTRRFTAHLVEIVDTHPSKDESGSLAQAPPAAPIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE06</accession>
    <name>A0A1Y2BE06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_520933</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE06"/>
    <dbReference type="FunCoup" id="A0A1Y2BE06">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE06"/>
    <dbReference type="InParanoid" id="A0A1Y2BE06"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000104">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="82"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="308" mass="35916" checksum="6430A600650F504A" modified="2017-08-30" version="1">MTQPMNQFMTDEYVLAYHGPLLYEARILLAENWTESTTLLGSTGPHYFIHYKGWKQTWDEWVPEQRLLKLNEQGFAKRRQLIEQQTKKTRPPGADSPSTSASKGKEKSSVGKKGEPVGKKRTRDSGVDTEADYLKRPEVKIVIPDALKLQLVDDWENVTKNNQLVTLPRRPNVRDLLEEYRNYVNDTKKDRTARATALLSEIISGITLYFDKALGNNLLYRFERAQYVEQKRANSDKAMSEIYGAEHLLRLFVNFGPFIAYTNIDTESLNILREYINDIMKWMIKEQKRLFVKEYETTTTQYQNLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE76</accession>
    <name>A0A1Y2BE76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidative stress survival, Svf1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_521562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE76"/>
    <dbReference type="FunCoup" id="A0A1Y2BE76">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE76"/>
    <dbReference type="InParanoid" id="A0A1Y2BE76"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="46"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="216"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="422" mass="45583" checksum="01CB09C21F87440C" modified="2017-08-30" version="1">MSWFSSKSNETPAQNFFPITSYSSGFGELSDTDTAWACTSNRGFQTETQIWYSILEDGSVLMVQIIWSYLGLFVIPATNQMTFKLYNPKTKKSVWKSINASGFKPNGRSSKSDQYEIKHTGTSKTEEKYDITASLDKHVQLSITVTKPASAPGFKFGQGKDGGISTFGQDREDGKRDGFVVHRFHPLAKSAGSIIVDGAVVDAKGEAMFVNAIQGMRPDSLASRWNFAFFTTGGGHPDGELGTVRALQMEFETTDGYGPKGAKSGRTKCSVGAVYSTALSTNPIIVVGQTKHADPSAFPTTSTDVCSATHFGAAHDKDTGYMAPSAVEFQWEGDRRDGQGRLSAKVRTEEGSGATVGKGGLMEKVDVLAEIPYVIRKGLAAVTGTKPYIYQNLSDTTLEVTTGDKVVPVKGWMFSEASFISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE78</accession>
    <name>A0A1Y2BE78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_564129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE78"/>
    <dbReference type="STRING" id="71784.A0A1Y2BE78"/>
    <dbReference type="InParanoid" id="A0A1Y2BE78"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF18">
        <property type="entry name" value="PEPTIDASE M48 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="366"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="594" mass="67399" checksum="FBF58A8FC7C683D9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE79</accession>
    <name>A0A1Y2BE79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_478415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE79"/>
    <dbReference type="STRING" id="71784.A0A1Y2BE79"/>
    <dbReference type="InParanoid" id="A0A1Y2BE79"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="400"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="498"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="756" mass="82058" checksum="B0D70B899206C494" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BET7</accession>
    <name>A0A1Y2BET7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_519397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BET7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BET7"/>
    <dbReference type="InParanoid" id="A0A1Y2BET7"/>
    <dbReference type="OrthoDB" id="2538319at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41950" checksum="EDD27170BA7A5871" modified="2017-08-30" version="1">MTMTEPRPYRAGLGLPEAVVIRSRPLPENARPILDGPLDPLSAQVTWREWNINPARHGPERMTRPPVFVPSQLTYDELGRSMADGVGVDVDDGIRREVESGQKVSEWYKALSNVQPEAELSRRSSPDRQAVPSSRPSPIHPEAGLSRRPSPYQSEDSLLCIQPEAGPSRSRSTSPPTRPIRVKRSEWFIRRALLKSATSTPTTPSTPLSIGSMLNIGPSQQRVKPAQYVLGPDNKGYTILRDRLGWEGGGLGRPEGYEPALASDDEIVPIDASGNIIIDLTADSDEEPVMRPGGPGRTAPIATALKLDRLGIGHRRSQTSTARKVTHTVEEIEKAQRRARYRKIEKVELGKKGKIKWKDKDKRERDERRRLLSMMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEV4</accession>
    <name>A0A1Y2BEV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein CFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cleavage factor two protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein cft1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_520958</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BEV4">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEV4"/>
    <dbReference type="InParanoid" id="A0A1Y2BEV4"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000730">
        <property type="entry name" value="Chromosome 15, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="11">
        <location>
            <begin position="106"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="12">
        <location>
            <begin position="549"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="10">
        <location>
            <begin position="1036"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="812"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1396" mass="152896" checksum="69CD346B780ABB67" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEV8</accession>
    <name>A0A1Y2BEV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_519477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEV8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BEV8"/>
    <dbReference type="InParanoid" id="A0A1Y2BEV8"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="6">
        <location>
            <begin position="245"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="594" mass="65557" checksum="DD98A4FD899E23D1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF47</accession>
    <name>A0A1Y2BF47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_519954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF47"/>
    <dbReference type="InParanoid" id="A0A1Y2BF47"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012440661" description="Protein BIG1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29355" checksum="4FC2C6BBEF0E5E9A" modified="2017-08-30" version="1">MRSQGLLIALALSLPSALAFKDTSPLLIWASEPNDALRDASEAVTSGVIRADEVYGTISSLGCTWERMAVVTVKDLHASHISALTLPASKADLHIPYLVRPDTASFEAAIDEWALVCGAGLSSGIQGLDGPGRRIVRLEMDKQGDTLKSLSNLSPPPDLILLHGSPLSSSSSSSSTRTSPSVATKIKRQEYPFPPSSSSSSITTTSTATSTSAPGNSTKGPLLDRVQILTTPIIVALLISFLIFIPIVGLGVSALAGIQVPPRMMEIGKGLTVGKDRKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF82</accession>
    <name>A0A1Y2BF82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_520457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF82"/>
    <dbReference type="FunCoup" id="A0A1Y2BF82">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF82"/>
    <dbReference type="InParanoid" id="A0A1Y2BF82"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="195"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="31629" checksum="E1F496369C97C3EE" modified="2017-08-30" version="1">MSESQLTSLRQRLTSTSSLLLERSRVLSLGLPPSASSQNQITRNLSTIRSELANLSEVVELESSGLVVGSGLSSSLKRKGKEGALAAEVREMEEGYDRLIGMLEEDEVGREKAKTLRREEVKRKSSPSPSTTSQPPRIDTTPALAPTQTPPNVPSFNVEPPTPAVERPFRDDPDLEHDDEDDDGATPHEMLSQQQSLMDDQDERLNLLSHSINRQNTLSIQIGSELDIHNELLEDTDAQMDRTAARLGSARRRLDKVAHDAKQYGSTITIVVLIFILLVLIIVFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG23</accession>
    <name>A0A1Y2BG23_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_520540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG23"/>
    <dbReference type="FunCoup" id="A0A1Y2BG23">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BG23"/>
    <dbReference type="InParanoid" id="A0A1Y2BG23"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="361" mass="40481" checksum="A4EC2D0227570527" modified="2017-08-30" version="1">MAPAQTVPCQYKTGKTLGSGTYAVVKECVHITTGEYFACKVLNKKFLVGREHMVRNEINVLKRVSAGHKNIVSLHDFFETTHNLYLVFDLCTGGELFDRICARGSYFEKDAAEIVRTVTSAVKYLHDQGIVHRDLKPENILFKSKAEDADLMLADFGLSKVLDEDAFSILTTTCGTPGYMAPEIFKKAGHGKPVDIWAIGVITYFLLCGYTPFDRDSQYEEMQAICNGDYKFEPAEYWSGVSQTARDFVRSCLTIDPTNRPTADELLQHPWLKAGVAFVTDTTSATGKDVDLLPNVKAGFDAKRTFRKAVLGMMAAHRFQENKTIGGQTPLEKERIRQEVEERKQEAEQEDVKDVIAQSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGS8</accession>
    <name>A0A1Y2BGS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_556776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGS8"/>
    <dbReference type="InParanoid" id="A0A1Y2BGS8"/>
    <dbReference type="OrthoDB" id="2558794at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="93" mass="10557" checksum="B45DE2D3BE26A1DB" modified="2017-08-30" version="1">MFAQSRRILSTAAPVARNMVARRAAHTAPVHEGPITKFFRDVPMPVEAYPLAALTVTMCSFAGYHAYKHIHEDRDHIRWLPGMGNVQYVQPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH18</accession>
    <name>A0A1Y2BH18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_518431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH18"/>
    <dbReference type="STRING" id="71784.A0A1Y2BH18"/>
    <dbReference type="InParanoid" id="A0A1Y2BH18"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="721" mass="77594" checksum="9432715779C85F53" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHB8</accession>
    <name>A0A1Y2BHB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_491169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHB8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHB8"/>
    <dbReference type="InParanoid" id="A0A1Y2BHB8"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012124096" description="Vacuolar sorting protein Vps3844 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="4">
        <location>
            <begin position="314"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="411" mass="43548" checksum="14E60B6B4CA72639" modified="2017-08-30" version="1">MRIIAIAALIAAPLISAVSQQPLQVYLHPSPSSPAHLTSAPTLSASQAKAVLAHHLGENIGDFEEIPQDESLWGHLVSMWSGNEDADRRARVVVIEGGVMSQDVIPTTLGQSPSFYLEEDSSSRALLAPYLQRASNFMHTLLKSLPSLSKSFKDTFELAGTKAAATLGRELSAFTALADSIPWLERLKDSHPWDAITISGLGHVDRHDEVWETGRAGVKAGLEAMSQPDSPPLLVIIIPSTSTRSSSHIVSRQIDDGDDGDDDDEDPVPGDEEPEEPQQPGDDDDDDDDEGEGDGDDEGSPEEPSGNGTLAQSCYTSNDSCSASTSCNGRGACALKLTTADGECWGCKCASGFAGVECQKEDYSVPFVILIFSTILLLGLLVGSVMLLMTVGDTKLPSTLTLAVGGHMKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHE1</accession>
    <name>A0A1Y2BHE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn-dependent exopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_518112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHE1"/>
    <dbReference type="FunCoup" id="A0A1Y2BHE1">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHE1"/>
    <dbReference type="InParanoid" id="A0A1Y2BHE1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="282"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="471"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="847"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="102346" checksum="27EA4C0FF6FCF50D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHM8</accession>
    <name>A0A1Y2BHM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_517488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHM8"/>
    <dbReference type="InParanoid" id="A0A1Y2BHM8"/>
    <dbReference type="OrthoDB" id="2596913at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="702" mass="76787" checksum="441B260E1EE6B6F5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHV4</accession>
    <name>A0A1Y2BHV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_517874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHV4"/>
    <dbReference type="InParanoid" id="A0A1Y2BHV4"/>
    <dbReference type="OrthoDB" id="2571288at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44937" checksum="0A9EBA13696B1513" modified="2017-08-30" version="1">MNSFSAQTHHLTKRYYWVYVYTSSSPTTNNKRETITTSNMQGLHIDLLVSILSLADRSTLAACLRVSRLFLQVAGPILYREIPFGPALSSVQDSDNGNGNGYSKIKRDLLECTRTMNIPSHPGSCCGLAEVSDLLPNLNTVRLSDQSPWYTYCHIGSNGPSSNLIFPWECSLLKQLRPSTLVLQDTLPPTSRAHVGFGSSFLQPTVRRIVITLQYGCFWIWGAEGTRMLDRLGPTVEEIVLAFGPWESGWKSSSSWKKDWPGSPCVASQIACMALEGHWRVTVVGSDNFNIEWAGEDEPESVVHRKVEDIQARSTLAKDKDETDSWIPRLDDNVATQEVQKRISFVDLDDWLKEEGKGVLAEDQLNSWRSMRSKQRQAKLSGRRISPPDPYFSPGLYWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIL0</accession>
    <name>A0A1Y2BIL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIL0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIL0"/>
    <dbReference type="InParanoid" id="A0A1Y2BIL0"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44488" checksum="D2314CC765207B50" modified="2017-08-30" version="1">MSPFEPAQGLGRKDGIEVGSGTRVKRNWGYSHNDEMQGSNALNLALSLGFGALEIDVHLKRPYDPMPYKTHSHTHKTDKSPPVDGLHTTASMFEDFASLPDEEYTLYTGHTDLSLTGLTLWDQYLGPLMTRLDGNNEGRKVGMEDKVVGVYLDDPLAEVAIVIDMKSDGDSTWPYLDKLLQPFLAKSYLTTYNASTSTLTRGPLRIIGTGNTPLAAVYHQPNALTSKYQGQDQSQSQGQSQSQGQSQGQGQGEGHDQGQGQGQGQGKSQGLGLRYIFYDGPLLTLSKKGKIDQTAYGPAAEFEWTASICPMASDRFPILDTVGVALPSWNPIVASLKAYTDEARRKGIESRWWGAAREPEWVRRKIWEMQKMGGVDWLGGDDLVDLSKWLAEQDLKEIQVERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ14</accession>
    <name>A0A1Y2BJ14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_563441</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ14"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ14">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ14"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ14"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013163965" evidence="10">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="214" mass="24288" checksum="96640E3E9EB602EB" modified="2017-08-30" version="1">MLGTCSRWAVLPLVLLLLSHRVQATALTAMLAGSERSCYYADVDGTGEKIGFYFAVQSGGNFDVDFVVMDPDDKLLLEGSNEKQGDYIFTANKIGEYSFCFENEASMSDKLLDFDIMVESEPRRALSAQQAPLREHTSTLEESTYKISGLLSSITRSQKYFHTRHHRNYSTVLSTQSRIFWFTVLESVIVIGMSILQIWVLKTFFSRSGRRYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJS8</accession>
    <name>A0A1Y2BJS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_516020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJS8"/>
    <dbReference type="FunCoup" id="A0A1Y2BJS8">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJS8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJS8"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="229"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="279"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="568" mass="62364" checksum="07291709C62EF068" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJU8</accession>
    <name>A0A1Y2BJU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_447387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJU8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJU8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJU8"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="74"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="240" mass="26221" checksum="B8732161618347AC" modified="2017-08-30" version="1" fragment="single">TTPESAQSYFTELFHLPPDRQIPPSLALQILTHKSFRNVKLLRHSSSPSSSSSSFSSSSTSTSSLSSSPSPSSSSYTHTLEQLASHNARLSFVGRRALASYFTMFLHSALAAVSSQRGLGLRDLDFLRGRSLQEKLDALRDAQNLGREVGSNWSVLDVMRWDENPNTIASAAHKIQGTTVEAIIGGIFTVYGSPAAHRTFHLHVLPHMAPQLRDPALIERAKTFQKNLLEEAGPAILGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL21</accession>
    <name>A0A1Y2BL21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_509859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL21"/>
    <dbReference type="STRING" id="71784.A0A1Y2BL21"/>
    <dbReference type="InParanoid" id="A0A1Y2BL21"/>
    <dbReference type="OrthoDB" id="2595178at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45013" checksum="D901EEA8FF84D2EB" modified="2017-08-30" version="1">MRSSVRLMRVCKSWRKEASAYLYATPCITATNLPLLTEQVVRGDKKWTDIHLHPYSTPGRWIQTLDLSHLTDQGFFSPHPTTIARSMFALSSLCPNLKHLVLPLGAEGGWEEHVIRSCARGLKALEGVHENTLAKVLRAESRCLKNLQVLSFVGAAGDGGYEGIGQWNNNQQEGSFKFDKLHTLILHNRVNDGPLLDALVDRELPQLKRLVITAYHQRTRAIHETHGNQLLSLTFLPPIEYPIIRSLPPLDTLDLHPQLLQLGFLLYNQYSHLSGILARAHELHHPLHTLTITNWTIPGSAPHDFLADLVNRPPPHLKVLNIDGYRWVNAELGRTACMSGVSGEKRVWAERLAGAGIEVRDCEGRKMPCLGDVRDAEGERGRRRASFASPPKKRDQSQDDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLB0</accession>
    <name>A0A1Y2BLB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FIST domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_510672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLB0"/>
    <dbReference type="InParanoid" id="A0A1Y2BLB0"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="46042" checksum="40F0C03F12469084" modified="2017-08-30" version="1">MLKRLYSTTTRSSLSSGILAQTLYSPTVASLTSFLTNSPRIPPSTSRSGSTSTSTLYLLSTSLESLPTLIPILQSHLISSDASYRSESIGSFSTCPPGCEPTLSILTVPTLKVFRTSLSGRPPAQVGRYQRPFNPSETGEGKKGREEDKKGSEIGEGSDFGFGKGNNEGWDGFWRAERGIERMEELEGIDAKGFLLLCDGTPRPVLDSISEMYPGMSSLGLITAPTPFLTGRPHTLIHNKDVFSTGTLGLALPFPLSTDTSYGLEQLDEPCSITSAQGNMLLKLSTTNPNPTQILISAIQRRTGGTLSKEEDFFLALLSPDDSKIQRAVKILSGDPSRGAISLEMEEPLLVGQRIQFMHRPQSTGDLTPKQGQITFAALRKSDNLDSIPLQGTPRVQDGFLACSEDGFINNSSICTVPGATCSWTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLK6</accession>
    <name>A0A1Y2BLK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 71-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_461579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLK6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLK6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLK6"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF9">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118850" evidence="3">
        <location>
            <begin position="28"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="148"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="771" mass="80220" checksum="F44F8A0143590D4A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLN4</accession>
    <name>A0A1Y2BLN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_555823</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLN4"/>
    <dbReference type="FunCoup" id="A0A1Y2BLN4">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLN4"/>
    <dbReference type="InParanoid" id="A0A1Y2BLN4"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY35686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="225" mass="24678" checksum="35D74F4089DF8652" modified="2017-08-30" version="1">MSAIIQKPAPAFAGTAVKEGSFEEIKLSDYQGKWTVLVFYPMDFTFVCPTEILAFNAALDKFAAINTEVICVSTDSEFTHLAWSQTPRKEGGLGPDLKLTLLADRNHAVSKAYGVLIPEEGIALRGTFFIDPKGTLRASHIHDLPVGRSVEETIRVVKAFQFTDEHGEVCPAGWEEGKATIDTSDKSKYFSKQAELEDQMDIDPANNGKRKTNVVNGNAAKRAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLW4</accession>
    <name>A0A1Y2BLW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioesterase-like superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_555896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLW4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLW4"/>
    <dbReference type="InParanoid" id="A0A1Y2BLW4"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="5">
        <location>
            <begin position="241"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="399" mass="43938" checksum="6619D66802018123" modified="2017-08-30" version="1">MAPQVSLLSTLAVAATSTPSHLPPSTSSFSSQSLWLPCGARGVFGGQVIAQSLASASNTISLPLGLHSFHCYFLLPADAGVPITYGVERLRDGKSYSTRLVRAWQGKKVVFILVASFALPPMELPPLIKGDEIPFSFVPTTKEPALSHSLRFANSPWSNTSDSRKKITDAAGPVPSYKARFQIDLKDDVVPWEESEEEESRWDRFLGDMASKVQGRARTAVEEYIQERRESPVGIAVAKKKRRVDDKEEERNRRMIWLKARLSPGEKLDAEGIKIMIAYMTDYQLIGTASRSVGLTRTSSPRLGMLASLDHSIHFYPFPANFDETRPILHVMEAALADVSSGRGVVRGLLYDENGWLLAVTQQEGVVRADLGGGKKEKGLVEGGGVEEVEEERRERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLY0</accession>
    <name>A0A1Y2BLY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="5">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_32499</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BLY0">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLY0"/>
    <dbReference type="InParanoid" id="A0A1Y2BLY0"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012214861" description="assimilatory sulfite reductase (NADPH)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="628"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY35778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1361" mass="147884" checksum="9CE552FC41E72BDA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM62</accession>
    <name>A0A1Y2BM62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_592062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM62"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM62"/>
    <dbReference type="InParanoid" id="A0A1Y2BM62"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000020">
        <property type="entry name" value="Pre-mRNA cleavage factor Im subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="203" mass="23338" checksum="97357384F52F9EB2" modified="2017-08-30" version="1">MRRTMLKYSSWTRLTPLSERESQPEEDSSVSARVARLQAQYKETGIRRSVDAVMVVIHMGFPHVLVLQVANSFYKLPGGYLDPSESDVDGLVTRLQEQLGLPATQQPENGPNVYSSEATDWKIHDCLSIWWRPNFDVFLYPYLPRHVTRPKEVKKLYLVELPEHKIMAVPANMKLHAIPFFELYDNAARYGPQFVGLPHILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM64</accession>
    <name>A0A1Y2BM64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_512474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM64"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM64"/>
    <dbReference type="InParanoid" id="A0A1Y2BM64"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="541"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="913"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="692"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="754"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1266" mass="140021" checksum="3519FB00E8331BBB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMA1</accession>
    <name>A0A1Y2BMA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_512795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMA1"/>
    <dbReference type="FunCoup" id="A0A1Y2BMA1">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BMA1"/>
    <dbReference type="InParanoid" id="A0A1Y2BMA1"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00349">
        <property type="entry name" value="Ribosomal_eL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047868">
        <property type="entry name" value="Ribosomal_L34e_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="114" mass="12451" checksum="0EB4C9BDC24C4F18" modified="2017-08-30" version="1">MAQRVTLRKRQPYNTTSARRHVVKTPGGKLVVHHIKKLAGSPKCGDCGDALAGIPALRPRKYATLSKRQKTVNRAYGGSVCAKCVKNRITRAFLIEEATIVKRVIKAKATGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BN06</accession>
    <name>A0A1Y2BN06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_510744</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BN06"/>
    <dbReference type="FunCoup" id="A0A1Y2BN06">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BN06"/>
    <dbReference type="InParanoid" id="A0A1Y2BN06"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY35555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="204" mass="22301" checksum="AF4316ACCACDEA87" modified="2017-08-30" version="1">MASNITFHPGAVEQDERGQLLGQKGATIWLTGLSASGKSTIATALEQHLLHKRLHAYRLDGDNIRFGLNKDLGFDPASRVENIRRIGEVSLLFSLSCSITITAFISPYISDRDLARALHVAHSPSIPFIEVFVDAPLSVVESRDPKGLYKKARAGEIKDFTGISAPYEAPLDPEIHIRTDELDVAGAVAKIVQYLEEKGLIGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ACV7</accession>
    <name>A0A1Y2ACV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_555449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000149">
        <property type="protein sequence ID" value="ORY20120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ACV7"/>
    <dbReference type="FunCoup" id="A0A1Y2ACV7">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ACV7"/>
    <dbReference type="InParanoid" id="A0A1Y2ACV7"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY20120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="254" mass="28874" checksum="711AA089AEADA1C2" modified="2017-08-30" version="1">MEEHRKRYGRRLDHEERKRKRTAREAHKASADTQKMFGHKAKLHHAKRHAEKIQMKKTLKAHDERNVKQKDDGAVKEGALPAYLLDREGQKDAKALSTAIKDRRKDRAAKYAVPLPKVRGIAEEEMFKVIKTGKHKGKSWKRMVNKATFVGEGFTRKPVKLERFIRPMGLRMTKAHVTHPELKTTFQLPILGVKKNPQSPLYTSLGVLTKGTIIEVNVSELGMVTTGGKVVWSKYAQITNNPENDGCINSVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADJ6</accession>
    <name>A0A1Y2ADJ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thioredoxin-like [2Fe-2S] ferredoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_83203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000131">
        <property type="protein sequence ID" value="ORY20576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADJ6"/>
    <dbReference type="FunCoup" id="A0A1Y2ADJ6">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ADJ6"/>
    <dbReference type="InParanoid" id="A0A1Y2ADJ6"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY20576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="250" mass="27484" checksum="ED36A2878818B1BC" modified="2017-08-30" version="1">MSVARSLLSSVRTAVVRPAGRRAFTSSSSRLSESLFVHRDTDYNNPNISFEFDAANMKRAQEIIARYPPQYKKAAVMPLLDLGQRQNKGWTSISVMNAVAKLLEMPKMRVYEVATFYTMYNREPVAPNFLQLCTTTPCQLGGCGSTKILETISTHLGIEPGQSTKDGKFTFIEVECLGACSNAPMMQVGDDFYEDLTPETTIKILDALAKGEKPKPGPQSGRMTSENSAGLTTLTGKPYGPGEFCQPEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADX8</accession>
    <name>A0A1Y2ADX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_555005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000128">
        <property type="protein sequence ID" value="ORY20674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADX8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADX8"/>
    <dbReference type="InParanoid" id="A0A1Y2ADX8"/>
    <dbReference type="OrthoDB" id="2563900at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="368" mass="38598" checksum="23CEFDDF4F2BFFE6" modified="2017-08-30" version="1">MTLIPPGAHLAPVDLPPPPPEADPREPSPSVRRGTRTPQKARSPAHSRSASPTRPLLPHPTSSDATSPTLHQPMPTASPVPIHFPHHLSRPSSPASIHSSSSAIFERDIELPAVASLSLNTTPQQGLNHKSSRLHMTHGSALDHTVPAVLDDAVEALANSKDDLEIEAPAVGMARQSSAIGSRKALSHSRSPSPISSRVSSPAQSPPILGQLTTQLATQAATQHATQAASPTRPAAPNRLSTGPHLPGAWSWQDAPIEEIPAIPSHLTPTKDKRRISFISYNDLLLSVPTTVTPLGDITSGNLSPEHLPGTISPNTRSPVLPSAGPADHKPRPAGLGLGEGEWSREGLGKGLEQRLEDLVQTDSNGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AG67</accession>
    <name>A0A1Y2AG67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_553550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000110">
        <property type="protein sequence ID" value="ORY21472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AG67"/>
    <dbReference type="InParanoid" id="A0A1Y2AG67"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="218" mass="24741" checksum="8661817BD7B8ED8A" modified="2017-08-30" version="1">MSKSFHYVIEHMEDDDETTHALPEWVKLEYSHMLTLIGPSSELHFTSLSSTSIPPLTTYLSSHASSSKAHAHTEPILEWLSTQHIPLGRVCLLDPKAPQVLCPEDSDKFDVFLYGGILGDDPPRDRTGELRKLGFEGRHLREVQMTTDTAVGVTKIVVEDKIPIEKIPYVDFPTITFNKNESIEMPFRYVRDEKGEPILPPGMKEHLKADLDRTIDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHC1</accession>
    <name>A0A1Y2AHC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_553769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000112">
        <property type="protein sequence ID" value="ORY21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHC1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHC1"/>
    <dbReference type="InParanoid" id="A0A1Y2AHC1"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="143"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="317"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY21375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="430" mass="47459" checksum="85E562E6285C877A" modified="2017-08-30" version="1">MAASGRPAPYDGIWTGRARRSDEQLRRNKEWLAPASASVVSSVVSFPLDSLKSRLQTLRERVSMPRLAAQIIREEGLRGLYRGLPLPLLTITINRTVSINVLDSIKRILISEPSADSLHGNPTANSPWIKARFGFFSRDSAQDIAATSLIAGATSGVVQCVLGAPFELVKTRRQLEFDIYKASHPGISATSSTQAHTSVRHPRNHSLPRSAIGMSATAPISHPNPGPALPKAHPVFVPPTTRQAVREIVNKAGYRGLYTGWRLQLPRDIMGSALYFAVYDVFRYQLGFRYSTSGVNSGFSDGLVQGDVPEWARGWLPKGVIPFVSGSAAGIMSWVVIYPIDTLRIKAQMRALSNQEPLTPWVQLMRLVRGTKEANPKPLSMGIFRLYQGLGVSSARTMLTHGAWWTIYDWVKAWIESQPFERAAFTIEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHK4</accession>
    <name>A0A1Y2AHK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_48682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000101">
        <property type="protein sequence ID" value="ORY21952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHK4"/>
    <dbReference type="InParanoid" id="A0A1Y2AHK4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="181" mass="20155" checksum="68484DEEB43A73E4" modified="2017-08-30" version="1">MSTSDSRSQAASHRSTALESQAHQAVYLSTLKQFGVRWTSLRERLGSGSGTAPLGRPAVRERVVETMPGWVQKLEDVVKPSSPPLLSTLYDVISEFDELDISLQSEKAWTKPALKIFEAIWSDNLFKVSECAFRVAMRYLAEGIAGFRCRPLIQSHSGCVEQKLGKGFSNTRYSCIPRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHS5</accession>
    <name>A0A1Y2AHS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_501992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHS5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHS5"/>
    <dbReference type="InParanoid" id="A0A1Y2AHS5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF15">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="72"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY21515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="561" mass="61337" checksum="31093955A88E7846" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI36</accession>
    <name>A0A1Y2AI36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase 9-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_552157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000098">
        <property type="protein sequence ID" value="ORY22124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI36"/>
    <dbReference type="FunCoup" id="A0A1Y2AI36">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AI36"/>
    <dbReference type="InParanoid" id="A0A1Y2AI36"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000248">
        <property type="entry name" value="N-acetyltransferase 9-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY22124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="243" mass="28052" checksum="A76D84B9519561E0" modified="2017-08-30" version="1">MRLNESTVIHGDRVILVPYRTEHVPTYHQWMQSLELLELTASEPLSLDEEFEMQRKWHLDEDKLTFIILERPMHLPTSCHPILSPAELRESRMVGDVNMFLPNGLAEDGECEIMIASPQDRRKGFAREALLLFLSYAIKTLSIPPRNLIARIGNTNSPSIRLFSQLGFGLVRIVKVWDEVEMRWGWTSLPTDHLENDPQHVIEDKDQEKDDEEGQEGGERGRQKDDSEWIGIDLSGRIGVWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJF1</accession>
    <name>A0A1Y2AJF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_551813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000095">
        <property type="protein sequence ID" value="ORY22327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJF1"/>
    <dbReference type="InParanoid" id="A0A1Y2AJF1"/>
    <dbReference type="OrthoDB" id="2594753at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="139" mass="15877" checksum="9D4B80BD897E8CEC" modified="2017-08-30" version="1">MAYQLRDHVRAPAAAGWVRFYSGLLMNDQTISLDKGPKRYTFVAYKLDSENTYFGGRAGTTTMVNGVVVHHGIVTAVNQRQLPPKPDYNVWAISEVEFVRLQALERLWWRDYDMAVAAGTDTARAMDFAHHMVLKQQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJU3</accession>
    <name>A0A1Y2AJU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_369809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJU3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJU3"/>
    <dbReference type="InParanoid" id="A0A1Y2AJU3"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000653">
        <property type="entry name" value="Polyamine transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF24">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="89"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="536" mass="59302" checksum="BAA0E9FEE17AE337" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKS0</accession>
    <name>A0A1Y2AKS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_550013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKS0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKS0"/>
    <dbReference type="InParanoid" id="A0A1Y2AKS0"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39676" checksum="962E9A8F5CF9A5A0" modified="2017-08-30" version="1">MEIYMSLASRLETDEPAASGLGFLDPTKPVLEIEFDLTLQKVEVANIKISGRSRKGAGGRSHKELQDQGPIIFVKLQQDLGALKSRKGDTGSVLWRSSYHLARNLLASHHHPPGAPLLPLLDLSKLRQARILELGAGTGLLAILLSPLCKEYTVSDRIENLRLVERNLELNGINPVSSARKSEHLHPTTSAGKAGHMYPASSASKAAKDRHERNRGESERKYQDGLVRLEEVDWTEVSRERQRHRSRHDQNNTGPYNPTSSEKDTYDLVLAVDCIYNENLVQPFVDTLAFYCPKGGRTVVWVVVELRSADVLTLFLETWLADSEGQWTIVRIFGEALGDWGSQKPRWVGWVGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKS5</accession>
    <name>A0A1Y2AKS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_550752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKS5"/>
    <dbReference type="InParanoid" id="A0A1Y2AKS5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="426" mass="46300" checksum="D0104C5D83B11E08" modified="2017-08-30" version="1">MREDFGHNPYHGYACQPTPAHRPACCCAPIGSYVEQDKRLVLYNAVSLATMESTLAALKSLQLYAPLTKSISSDVLSVLAIALGSKRNLDLYLLVRGLQPPLPSEVQVEPRPPTPPPFTTHRRSFLNRIIPNKRQLKLIGTQAVILVGGLVLPRLGIQWSTVFEGALSIVFPQPKDINLTIPRSSTDTEYNLSMKTRADAPFFARDDGRCYLALAAAVVTVFAIASGFDSLTILILPAWVLFIFTGLNCSSFSTRGNAIFILSFVGLVTIGGTVGGLIVQSIYPPNLDKIQTSTRLQPSAWLLDMIMIPTKILLLAPPAAIISLTHRFEATSRNTETGVSDFPSPPSGAPRLISSLGPLYCTGLIVTSLTVAGVIAATEHYKDDIFIIDILQVDSVLLTTIFPLLGIGLAAWMTGNVKNWWSYHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKT2</accession>
    <name>A0A1Y2AKT2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_381828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKT2"/>
    <dbReference type="InParanoid" id="A0A1Y2AKT2"/>
    <dbReference type="OrthoDB" id="2571873at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="392" mass="44808" checksum="526BD9ED8ACFD7ED" modified="2017-08-30" version="1">MSGLSLFVKPSHPGLFATGYPTPPLTPTSPLTPVTPVTPTPPNPSYAMLRQHHAYALKYVIAKLRWEQLNNDYLRGEDAWLKHNVMIQKLEQELMDVEAAQKTLDPLPPCYAPMAFPKPHGPMTKEQYDQKKLDDMEKERQLDEKLYEKFPFVKQLFIGPLTKHQARNFKMAKEQLLEGDLDQISLLLPDENVAMLNAMHGAGGKHNPDKKSYEQRRFEKEQAKVAALHPPTPKKVPRIGPMTKEEYLQSQPKYGPKTKSEAMLQTQRDQREIILTWLRRPWDRFDQDAARLLEKLGGLALHKLEEESKASKHRHDLVKGRNEAPERVEGKENKDVKAVKDVKDGRDDKAVQSIKDGKDIKDGKDIKDGKDVRKMKDVKETPKGGRVQEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALB7</accession>
    <name>A0A1Y2ALB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_507848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALB7"/>
    <dbReference type="InParanoid" id="A0A1Y2ALB7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY23368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="236" mass="25617" checksum="98844ECE97222559" modified="2017-08-30" version="1">MSDSSSNSFVFPPGRPTFFSLCVLPSSLMDPSGHPTPASSSADPSFLLFGSGESLSNHLTAVHDNLCKPTPNSNATYWLMTGTLALAAAAHGTKTKINNKEITELCSAVHDYNSLQSFRETTFSGNATESELKATMGDMNDPDMKNCAEQSFRAWEKYTSDEMSPLMLQSLLSCHELHPGQTHFGYQSSMDPSFTHNLSRFEQALEAHRKPSHITEVSEVDESSGVESLIGGVEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALQ0</accession>
    <name>A0A1Y2ALQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_549216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALQ0"/>
    <dbReference type="InParanoid" id="A0A1Y2ALQ0"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013096026" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="69149" checksum="1F7722C19B7B4C00" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM77</accession>
    <name>A0A1Y2AM77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_344039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM77"/>
    <dbReference type="STRING" id="71784.A0A1Y2AM77"/>
    <dbReference type="InParanoid" id="A0A1Y2AM77"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="158" mass="16923" checksum="51F2E6768705518F" modified="2017-08-30" version="1">MKPGGRVVTVGSTASFQLKFANPALKKRAMDDKLGLEDLEQLFQEYKAASSKPEDDDGWNRAGYAPAYSASKGFMNLATAALAREHPELIINVGCPGICETAEIPKGVNWVLKTTDEGCRLPLRLAFDDLDGVNGQFWAGKSTADKGPGVGKQYGNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMW8</accession>
    <name>A0A1Y2AMW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMW8"/>
    <dbReference type="InParanoid" id="A0A1Y2AMW8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="349" mass="38484" checksum="9A1FC24E766D93CE" modified="2017-08-30" version="1">MSKSGSTHLPSTLPSSTFPIKTDIPTSSTIATLTISRIRRATATSAPPDTSGSRGYTFKVPLLPIEIPATFELLTSNPPDPPISECPTSDRLYPPDPPISTSDPPDSPTSGCPTSDPALQSRGDSAKPKESDPTKSKKRRRRRDTTMAASSFTSHSPTQSYQNPSRLQKETNSLEVVSSEAFKSIYMSMTASEVEQLKKVQTRTMEKNGTEQSDGTEIAQTDGMKKKKTQINEDLIVLTDKELYSLWASLKQSKRRISGQLKDELRIAAKQSSGGWTVVPEVRRNRTLEQKDTSEGRRVRKILSFTYTFVYTSNDGSVTIESKLKGNLHIPDQSLVAKWDPMLSIDHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANA4</accession>
    <name>A0A1Y2ANA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_547978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANA4"/>
    <dbReference type="InParanoid" id="A0A1Y2ANA4"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="428"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1203"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1330" mass="149508" checksum="7789B19CFC9439F2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AND3</accession>
    <name>A0A1Y2AND3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_337216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AND3"/>
    <dbReference type="InParanoid" id="A0A1Y2AND3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="199" mass="22091" checksum="086E6B50D950F800" modified="2017-08-30" version="1">MSTTTLLDENHTGYIATTEVEQLPGERGVESYERKIREAMETFQGEIESMLDTGLAGRSNPPPIFPYLELDRTGNTSMRFRSLLADPDSNYQQVVCYQQDQETASRERFANTDENTLPIVDWRRFPIGGSFDLDSSTQMTPQNSSSGTTAANSLNTFPPQDGGTASFTSSVSQILISSTPRTQHHLSSGKVPDHGRYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP33</accession>
    <name>A0A1Y2AP33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_547449</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP33"/>
    <dbReference type="STRING" id="71784.A0A1Y2AP33"/>
    <dbReference type="InParanoid" id="A0A1Y2AP33"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013299490" description="ABC transporter domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="346"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY24311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="976" mass="104259" checksum="5696EA7772DB4282" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP80</accession>
    <name>A0A1Y2AP80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ER-golgi trafficking TRAPP I complex 85 kDa subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_547160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AP80"/>
    <dbReference type="InParanoid" id="A0A1Y2AP80"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1325" mass="144924" checksum="984DB01457446752" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP91</accession>
    <name>A0A1Y2AP91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_340023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP91"/>
    <dbReference type="STRING" id="71784.A0A1Y2AP91"/>
    <dbReference type="InParanoid" id="A0A1Y2AP91"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="263" mass="29976" checksum="B699CD720C76FEE3" modified="2017-08-30" version="1" fragment="single">DRNDHRQRGSIEALYVEIELLKDLYHPNIVAYLGCETSPQYISIFLEYVPGGTIASIYRTPNQGRFEEQLVKFFTAQILEGLAYLHDRNIWHRDLKGDNILVDAAGVCKISDFGISKQTEDAYNSFGQATNMKGSVFWMAPEVIHSANERTYSGKIDIWSLGCVVLEMWTGTRPWGVMEQVAAMFELFNKRSRPPLPPDIHLNDVALDFMNEKCLAKDPRDRPTAKELMEHRFIAERDPTWSFATSKIGKAVAKKAPRTMKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APY6</accession>
    <name>A0A1Y2APY6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_320510</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APY6"/>
    <dbReference type="STRING" id="71784.A0A1Y2APY6"/>
    <dbReference type="InParanoid" id="A0A1Y2APY6"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000156">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="121"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="151"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY24592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="551" mass="61814" checksum="9D14D4AB51A616D0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ56</accession>
    <name>A0A1Y2AQ56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_546348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ56"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQ56"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ56"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="356" mass="38083" checksum="5D983F0631E6656C" modified="2017-08-30" version="1">MSSSTGTGTAKTIPTSLVIFTTSQSPLGLRYEHPRKPLLVIPPLIHRSLHAALDGETPSVLIQDGISYLPHPDTLGKQDIPTRPTGPPSSSSSSSSPVIADPILDSQPARIISRGDSEITVKFHLVGNGTSTDKVKWIEDGLELLGRYKGLNQVDTLLVGFKGIDYRGKKTAASEMFGCGAEGLESDTGSEDVSDQARKQVLDIWQDVKAKVEGKVGRIGTMYLPLGLLKDVKELDGKLAVNALDTPDCHSLPKDYSGWAKESGVELWAGGGGEGSDPLPSVHLHNLLSEFNDKINTLGVSHGAGDVILLRKDGLKFEQGGKLAVDVRWVLSYTLVSSTRGLVRDKGYIVMADIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQE1</accession>
    <name>A0A1Y2AQE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_499916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQE1"/>
    <dbReference type="FunCoup" id="A0A1Y2AQE1">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQE1"/>
    <dbReference type="InParanoid" id="A0A1Y2AQE1"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY24694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="389" mass="44546" checksum="E283CF647CA19DEA" modified="2017-08-30" version="1">MPSAAPPTAGEPSKPRASPLPKDDPLRERILVCGWRKAGKSSCIKTVFQGVPTKDVPYFGVTQKIEKINYDTIIPLQIWDTPTNFELDQLDVPLGSFSTIVYVMDMQQEDMYPEIIARFVQIVVRAHFANPNMKFAIFIHKAEAMAQDYREDNYRQIQQTAEDELLDFPFHTIQNLAPSLNFSDPSVTNALANDLVGSIRYRITSAYEANLREAWSGVVQGVMEMLPSVEQLLLNFTANCGMDNSFLFDIASRVIVAADNRGKNDETLDQVTDYLSRFMQFRELYKNLHLEVDENGPNSADGDEEDKEEEEEEEEYEPEGWWDEEDPEIPWMTQATRLTPNTTLALWQFTPHLALVVLLRTATWEATRGMIEYNLTFLRQGVRRILMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQE2</accession>
    <name>A0A1Y2AQE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_545922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQE2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQE2"/>
    <dbReference type="InParanoid" id="A0A1Y2AQE2"/>
    <dbReference type="OrthoDB" id="5964929at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="96271" checksum="60E21532046BC16F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQM0</accession>
    <name>A0A1Y2AQM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_313078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQM0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQM0"/>
    <dbReference type="InParanoid" id="A0A1Y2AQM0"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="326" mass="36946" checksum="D5E748BAE9CDD630" modified="2017-08-30" version="1">MPVACRRCRQLKVKCLVPPDHREGQPCQRCVRASLDCVFENHQRGRKPGFRLTDRSRALSRLKSAYRVLHAQDTDSRDLLASPDPGPSSRRNSQQFHLQSSFRPPHSLGVSCQYTSIEPTDPLRPPAHASFLPTYSDMEPSHRSPSSLREFFASICGEVMGEPVEALDLYRQDPVACGYMSEEEARQLFEDFHERIGPAIELLDPLLHTHDWVRNRSQFLYTTIIAVALKFSHDPDIVLLGRCQALAQDQLLRTFVDGLSSVESAQALLLLTEYKEPEDKSMYLLVGLACRIGMDLGLGNTPTSGDERMNRNYTRTWLALFCADQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARH3</accession>
    <name>A0A1Y2ARH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M24, structural domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_544832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARH3"/>
    <dbReference type="FunCoup" id="A0A1Y2ARH3">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARH3"/>
    <dbReference type="InParanoid" id="A0A1Y2ARH3"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="8">
        <location>
            <begin position="58"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="398"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="9">
        <location>
            <begin position="678"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="742" mass="83835" checksum="2BF1EB02511CF924" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARK7</accession>
    <name>A0A1Y2ARK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_544980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARK7"/>
    <dbReference type="InParanoid" id="A0A1Y2ARK7"/>
    <dbReference type="OrthoDB" id="2565091at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="606" mass="65333" checksum="3073C8F8D6A93484" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ART9</accession>
    <name>A0A1Y2ART9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_544640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ART9"/>
    <dbReference type="STRING" id="71784.A0A1Y2ART9"/>
    <dbReference type="InParanoid" id="A0A1Y2ART9"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="168" mass="18678" checksum="EDFC954F8325BEEC" modified="2017-08-30" version="1">MRLQQLQSISVLTRSSSSPSSSRLITARCSLSTLLAATSTSPSTTSSSSSTSPPAFTVNEQSNSTATSTTTTHEPTPDLSVLRTQAIKLYKELYRLGKDYPDPAYKFNDRLRRAFEKNAKISDPHALKKQLELGEHIKKEVLALISLKKYRHLRRSYHADEPPRATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARZ5</accession>
    <name>A0A1Y2ARZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_561095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARZ5"/>
    <dbReference type="InParanoid" id="A0A1Y2ARZ5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="218" mass="24348" checksum="869972AC74ADBDD1" modified="2017-08-30" version="1">MSLDSLCDESEILQQYSPLDGLLNRLDVLATDASPPRVILLTTGVVLIDTEVHWIIALTEKKHDGGCKRWTHEETLDTLNGTQSGLFSNMVQIKLASLKGLVKLETDDSGEPSKVTRFQRSYSADVQVTFTLAEVNEIVLEGFTAKNHDPSVDTEQMLFDAILTLLPRTGPELGGGAAGYWRFKVSHLKKTIKDFTSFWDEEKWVERPASEIRPLEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS31</accession>
    <name>A0A1Y2AS31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_544373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS31"/>
    <dbReference type="FunCoup" id="A0A1Y2AS31">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS31"/>
    <dbReference type="InParanoid" id="A0A1Y2AS31"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="330" mass="34984" checksum="E4EBD6F4D5463358" modified="2017-08-30" version="1">MPSPAVSRLSSSMPGVDGPSLIRQLANFVPPTQPVSAGRQLPTSVPLPVLPAVEAAKRLAAFAAVDRHVGLEHKFIGIGSGSTVPYVVDRIVAQGPEANRHRVFIPTGFQSKELIIKAHLTLGDVDQFPNLDVTIDGADEVDNDLNCIKGGGACQLREKVLAEAATTWVIVADYRKNSHVLGTTWTQGVPIEVAPFAYAKVLTNLSQLGSPHILPNGKPGLALRMAKMKAGPVVSDNGNFIIDAPFPPEQMKKPAELLHQIKMLTGVVEVGLFCDMAEAAYFGNEDGTVMIRHADGAVENLNSVPATPDLASALTSAFIEDERPAPDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASX8</accession>
    <name>A0A1Y2ASX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_543640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASX8"/>
    <dbReference type="FunCoup" id="A0A1Y2ASX8">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASX8"/>
    <dbReference type="InParanoid" id="A0A1Y2ASX8"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY25652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="101" mass="10978" checksum="2490DD6C08E267D6" modified="2017-08-30" version="1">MSFIFGGKQQNPNAVDPAKIEMAVAELDMITDVFNRLVSSCYSKCIQPNPMSHRYVEGDLLKGEGVCIDRCSAKFFEVNKLVGERMQTMGGAAQAGGSFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASY2</accession>
    <name>A0A1Y2ASY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_308504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASY2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASY2"/>
    <dbReference type="InParanoid" id="A0A1Y2ASY2"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="139" mass="15249" checksum="2B3C60D1793CB03B" modified="2017-08-30" version="1">MAPLPRTFFDFTVGDLPLGRVVFELFSDVVPKTTENFRALCTGEKGLSPISHVPLHYKSSIIHRVIEGFMIQGGDFTKRTGAGGESIYGRMFEDERLEGEGTEVDKAGLLVMANRGPNTNGSQWFITLAPSPHLTGKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATA5</accession>
    <name>A0A1Y2ATA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_544088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATA5"/>
    <dbReference type="InParanoid" id="A0A1Y2ATA5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="56" mass="6347" checksum="C6D5C64072D30EAA" modified="2017-08-30" version="1">MANKALSKSLQALRLGDFVALLFLVCFEEAHIIIVNQLFRIRPIERLALDAAHVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATL7</accession>
    <name>A0A1Y2ATL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_286297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATL7"/>
    <dbReference type="InParanoid" id="A0A1Y2ATL7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="268" mass="29045" checksum="B842F8CDB7AD345D" modified="2017-08-30" version="1">MPGCWTCRKRKVKCRDFLSTSESPSGSHSSTDDSCPNCRRLKLHCIRTKPSTSEEESDAAVRGWKPLRKRSGVLSKINHGSETNGSPLDCNRPRSTGTGDDVFCVRDPRSRQDNLTTGGGAAESQATYSSNTGMQSTPPTLDLGMDAMSSQSNIFAAVPLSSGTNSLFPWDTGQTATSSFDIVDPWTITTVSAAGHGNSSTGNGQLYVVDEEDEGSALLSQYPSTNDCGPERTWYKSLVDVIYPDQDLIAHYLVSRLIFCMSLLSCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATR6</accession>
    <name>A0A1Y2ATR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_542663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATR6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATR6"/>
    <dbReference type="InParanoid" id="A0A1Y2ATR6"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="253" mass="27570" checksum="0F7C145594D86A2A" modified="2017-08-30" version="1">MSLTPQALRLLSREVVSLRSDPPEGVRVVFDEDDLTAMEGWVQGPDGTPYQGGYFRIRFDFGLEYPNLPPKCTMLTKIFHPNMSKSGEICVDTLKKGWKKEYGVGHVLVTIKCLLIYPNPESALDEEAGKQLLADYDGYCKYAKLITSIHATPKLPPPEFRNTTSKTIPQASSSSNTHVIPSTSTRPPNSTSSTTSSKPAPLQTRVDQEQSPVLPSTATMDEKALKPATSTKVAGGTKTSTAASKAKRGLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUC7</accession>
    <name>A0A1Y2AUC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_542039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUC7"/>
    <dbReference type="InParanoid" id="A0A1Y2AUC7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="52" mass="6068" checksum="5D031A3F894AA36A" modified="2017-08-30" version="1" fragment="single">MGYASELQYLKRLSGKFCLGRDRVGCLYTFLISLSFLLVVLGRREEENEMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWM2</accession>
    <name>A0A1Y2AWM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_539960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWM2"/>
    <dbReference type="FunCoup" id="A0A1Y2AWM2">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWM2"/>
    <dbReference type="InParanoid" id="A0A1Y2AWM2"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="299" mass="35048" checksum="C564ECD293C55A8E" modified="2017-08-30" version="1">MASFFAFSSQPVEVEVKLAGEEERRQVEVKGEKDKKEMCPVYYDGESVVGQVHVRVKDGKKFQHDGIRIELIGSIELFYDRGNHYEFVSLSQELAAGGEMRSAQTYDFTFKNVEKQYESYSGINVKLRYYLRVTLARRIGEVVKEREIWVHSYRMPPDSNTSIKMEVGIEDCLHIEFEYNKAKYHLKDVIVGKIYFLLVRIKIKHMELSIIRRETTGAAPNQYNESETITKFEIMDGAPVRGETIPIRLFLGGFELTPTFRDVNKKFSTRYYLNLVLIDEENRRYFKQQEITIFRIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWN4</accession>
    <name>A0A1Y2AWN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_539600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWN4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWN4"/>
    <dbReference type="InParanoid" id="A0A1Y2AWN4"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="163" mass="18385" checksum="2BA945F0CDD4548A" modified="2017-08-30" version="1">MSAQQQQQKYSRPAYEIIKVSTPEELSESMAIRYEVFIEEQGYDPQIEVDDYEDPISTHFLLRLETGEFAGTVRVQDKRGKLGRLALRKAYRGMGLAKPLCYAVHDYIRGIGGKEIIADAQASEGGTGVNAVGFYDKLGYYPRGEKWVKVGTPHQLMVFDLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWS4</accession>
    <name>A0A1Y2AWS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 26S proteasome regulatory subunit rpn-6.2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_540030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWS4"/>
    <dbReference type="FunCoup" id="A0A1Y2AWS4">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWS4"/>
    <dbReference type="InParanoid" id="A0A1Y2AWS4"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000019">
        <property type="entry name" value="Proteasome regulatory non-ATPase subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="221"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="424" mass="47628" checksum="FE55C407E7BB841A" modified="2017-08-30" version="1">MAIPPAEPSLSKQLTEANSAASSDPTKAEELYQGILKRKSTDEDDLRDQEQALIKLGALYRDHEKAQELAQLVSDSRAFMSQIAKAKTAKLIRTLIDYFPPSARDLQMQVTKDNITWAREEKRVFLRQSLEIKLVGLQIDAENYRTALSATESLLKELKQLDDKIILTEVYLLESRAAHAIQNLPRAKAALTSARTTANSIYCPPLLQAQLDLQSGATNADDKDYKTAYSYFFEAFEGFAQADEKDPRALKALKYMLLCKIMMSLPDDVPPLLLLKSAAPHAGRDLDAMKATATALKERSLELFKTALKEYQQQLQQDPLIRSHLSILYDTLLEQNLVRVIEPYSSVELSWIAQEVGQSLQVVEEKLSQMILDQVFHGVLNENVGTLEVYDEPVEDPMYNTALDTLKQMGEVVNSLYVKASELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX73</accession>
    <name>A0A1Y2AX73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_538711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX73"/>
    <dbReference type="InParanoid" id="A0A1Y2AX73"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="107" mass="11463" checksum="499C2E4E8570DC96" modified="2017-08-30" version="1">MGDGSAESFHTSSTTLDESQAQMKLRRPGENVSTPGSQESTLPSTPAESPILPSFIINMLSTYSKPATSPSPQASPKVGGQYQWTSTNDLQVLVSHLDYEALRFTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXZ3</accession>
    <name>A0A1Y2AXZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_538135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXZ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXZ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AXZ3"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="190"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY27463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="460" mass="51659" checksum="807ABB7EB170504D" modified="2017-08-30" version="1">MLRSLRPVLSAIPSSSRAASIPFRAISTSPIRSLATPSSEERVSPLRAHSVEELHGLSAEEILAESGKRKEASMRHFTVNFGPQHPAAHGVLRLILELNGEEILRADPHIGLLHRGTEKLIEYKNYTQALPYFDRLDYVSMMTNELCYTLAVEKLLNIEVPDRAKWIRTLFGEITRILNHLMAVLTHAMDVGALTPFLWGFEEREKLMEFYERVSGARMHAAYVRPGGVAFDLPHGLLDDIFKWATQFGSRVDEIEEVVTGNRIWMARTIGVGTVTAQQALDYGFSGVMLRGSGIPWDIRKVAPYDMYDQVDFDIPVGKNGDCYDRYLCRVQEFRESLSIIHQCLNKMPTGAIKVDDHKIVPPPRASMKESMESLIHHFKIFSEGYSVPPGETYSAIEAPKGEMGVFLVSDGTNRPYRCKIRAPGFAHLAGADFIMRHHYLADAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B019</accession>
    <name>A0A1Y2B019_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_536634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B019"/>
    <dbReference type="FunCoup" id="A0A1Y2B019">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B019"/>
    <dbReference type="InParanoid" id="A0A1Y2B019"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY27890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="491" mass="52027" checksum="CCA64AC9942D451E" modified="2017-08-30" version="1">MMSFAQAAKRQAATGLRQQVTSRALRTSAPASALSKFGMPAMSPTMTEGGIASWKLKEGDKFTAGDVIVEIETDKATIDVESQEDGFLAKIILQDGAKNIQVGTPIAIIGEEGDDPSGADALAAESDASSSQSSEPPKETEPKKEDTEKEAPKQTSSGTTSALQTPADQTKYGSGSTTEPPKAPELKGDKPKFFASPLARKIALEKGIPLAEIKGTGPEGRIVKEDVEKYSASSSTSSKAATTPTSGASATPGKAAPAAPAEYEDVPTSNMRKTIGKRLTESKQQLPHYYLTVEINMDRIAKLREMFNKAGEGKTKLSVNDFIVKAAALALAEVPEANSAWMGDVIRFYKRADICVAVATPNGLITPIIKDVGAKGLATISAETKALASRAREGKLKPEEYQGGTFTISNLGMFGIDDFTAIINPPQSCILAIGKTSTKLELAPEDPKGFKAVQVMKATLSSDHRTVDGAVGAKWLKAFKDYMEQPLTFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Q9</accession>
    <name>A0A1Y2B0Q9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="6">PME-1</shortName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_208751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Q9"/>
    <dbReference type="FunCoup" id="A0A1Y2B0Q9">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0Q9"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Q9"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="122"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="413" mass="44519" checksum="83E3E7C17F471098" modified="2017-08-30" version="1">MSEHFRKAVLSRLPDLPPTRAPWADAPDEDEDTEELEDDQLGELGGASFATSKRAADDLSPISASQFFTQALEVTPPSSDTTFRVYLTPPVIPATSSSSSSSSSIASGTPLGQSQNRHGTVLVCHHGAGAGGLSFAALAKEIKEKSQGELGVVAWDGRGHGKTRTEGPKEKDTDLSLPTLLNDFMGVLQHLFPDPKESPSLVLLGHSMGAAPILSASPLLQQAGYTVAGVGVLDVVEGTAVEALPLMKSILGQRPQSFRSVIDGIHWHITSNSIRNPLSARVSVPSYLVPEQDQTDPGPSGKQIWRTDLLATEPYWEEWYRGLSSRFLTAKCARLLVLAGQERLDKELMVGQMQGKFQLEVMTDVGHYLHEDDPAKLASVIVTFWRRNTRVVLPPKIGSTGSSGIAVRRVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1F5</accession>
    <name>A0A1Y2B1F5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Afadin and alpha-actinin-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_535495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1F5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1F5"/>
    <dbReference type="InParanoid" id="A0A1Y2B1F5"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="606" mass="66247" checksum="D3378DB8A87E474A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1T5</accession>
    <name>A0A1Y2B1T5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylinositol-glycan biosynthesis class S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_533920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1T5"/>
    <dbReference type="FunCoup" id="A0A1Y2B1T5">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1T5"/>
    <dbReference type="InParanoid" id="A0A1Y2B1T5"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="656" mass="73214" checksum="D54FE69C686299F2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1W7</accession>
    <name>A0A1Y2B1W7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_482486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1W7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1W7"/>
    <dbReference type="InParanoid" id="A0A1Y2B1W7"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="108"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="333" mass="36075" checksum="A313FFB41393A8F0" modified="2017-08-30" version="1">MSTTLTKKQQKAQAFRAKQRAKKSGKGETEQDEVPEVDLLEDDVPAETEATIAESSSSSSKKRKREGEEEKEPKASAGKGKGKKTAWDDEEQDGDAAKKTKKDIKQRFILFVGNLGFKTTRDAVQNHFKPVLTQTPSVRLLTTKATPTVPAKSRGIAFLEVPTSTDLQACLKLHHSTLDGRRINVELTAGGGGKSEARQGKITERNERVGVQRERKAEKEKEDGTGDAGAEQARESIQSEPVKRKRVEGQDGVVDGPDGKVKIRGGRRVKVKTDNTEETSTKQTDKAQLSGWTSRTAGGGRGQQAARGGRGRGGAPSGRRKFEPTGANAVFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B248</accession>
    <name>A0A1Y2B248_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_200190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B248"/>
    <dbReference type="InParanoid" id="A0A1Y2B248"/>
    <dbReference type="OrthoDB" id="5599874at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="2">
        <location>
            <begin position="443"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="592" mass="64238" checksum="B8DAF51A6BEC32F6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3B6</accession>
    <name>A0A1Y2B3B6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_532323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3B6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3B6"/>
    <dbReference type="InParanoid" id="A0A1Y2B3B6"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052567">
        <property type="entry name" value="OP_Dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202:SF1">
        <property type="entry name" value="HD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="316"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="475" mass="52408" checksum="3BAA92A57F4FC2A9" modified="2017-08-30" version="1">MIQIPDYNVPYALSPEQIKSFHEDGFLMLPDVLKPDQVKDMQAWSAEVKGWPNRLGQHMHYEEVRADGTTGLCRTENYVNYHKGFNDLFRGERLTGLLSELMGQRAVLFKEKINYKEAGGSGGFDAHIDASAYNHAGANKHQTFLMAVNDMDMSNGCLEVVPGSHKLTIPLAPNRCIDPTWEAKQTWVPVPMPAGAMLLFGSYLAHRSGANSSPKPRAAIYATYNGISEGDNHDSYYVHRRKLWPPTSERVPGEKYSEGAMIYAYGSPMSGGKESIAETLSSGNKKQTITSTVTDLFHLLEAQGQEGYIGEAISQLEHSLQAAEAARQSGADDATVTASLLHDIGQFLPHANAKEMMHNGESVGRKSHEVVGEVYLRKLGFPEKVCQLVGAHVVAKRYLTATEPGYLEALSSASKASLKYQGGPFSSQQVEEFLQDPLHKEKIALRQWDDQAKRTDIKAPGLQTFRPIVERALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3C2</accession>
    <name>A0A1Y2B3C2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_532387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DExH box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3C2"/>
    <dbReference type="InParanoid" id="A0A1Y2B3C2"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001714">
        <property type="entry name" value="ATP-dependent DEAD/H RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="768"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="697"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1557"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1635"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="716"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1557"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1575"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1639"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1665"/>
            <end position="1691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1701" mass="188944" checksum="1CCFB28A07FF83C1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B492</accession>
    <name>A0A1Y2B492_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipid metabolism-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_531404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B492"/>
    <dbReference type="FunCoup" id="A0A1Y2B492">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B492"/>
    <dbReference type="InParanoid" id="A0A1Y2B492"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="138"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="37935" checksum="6AC63E2AE53F3618" modified="2017-08-30" version="1">MTSFADTVRFCFPAPRPPPSTLPLHGLSSNGAASHSRNDALEPDLSEGVAKATVGNVLRAYAPDWILAAVLWGVLAILNRSPGHKREFSLNDISIQHTFAEHERVPPTLLGIISAGIPLLVLLPISILVARNPWDVHNSVIGLFMSYTMTGVVTQIVKMMVGRPRPDLINRCMPAPGATDAPVFGLSTYEICTSTNQARLDDGFKSFPSGHSSLSFAGLGFLSLYLAGKMHLWDKRGHRNRAWFALSPLLGAAMVAISRTEDNRHHWQDVLVGSILGLAIAGVTYRCYFPPLSHRQCHLPLAPHTASPEELFDPDASVEDGRVQLLSEENDRAARPSEEEVVWSSQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5X1</accession>
    <name>A0A1Y2B5X1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_529990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5X1"/>
    <dbReference type="FunCoup" id="A0A1Y2B5X1">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B5X1"/>
    <dbReference type="InParanoid" id="A0A1Y2B5X1"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF96">
        <property type="entry name" value="BCDNA.GH08385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="539" mass="60038" checksum="BA41FBA8C116CCEE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B694</accession>
    <name>A0A1Y2B694_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_587913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B694"/>
    <dbReference type="InParanoid" id="A0A1Y2B694"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="369" mass="40432" checksum="2C1189EB18889E4C" modified="2017-08-30" version="1">MSKSWTRPSATAFRKLSRKRIRRLWRGITAYKSTFTGAASSKISHPTIPSVNYVPPGHRFPLLPMTTPQCSSTSGNPYPICPVTPTSSEGSTMPFPIPHSSTFPTYQPRPKFCLPGTKESIFPSNPSPIPFQLVGTSTITYRVPSYPSNDFDTPETTMLTVALRESNSPTRGFVEAFTNGKSSCRIYTVYSLTTTNDDISSPASQGTQRESACSSKSDGHSGDNQAQSVGDLEPTIFVYTPRSIRSASPVSSSADTRTATCVDSQDDEELSEAIELSRISWEDARTGLRNQLVSALQQLDTVSSTTNKEQGQWPLGNRGSYSSMDLVGGQQQDETRQRARDLISDYIWRGYATKTDASLLSDALDEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6B2</accession>
    <name>A0A1Y2B6B2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_530571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6B2"/>
    <dbReference type="FunCoup" id="A0A1Y2B6B2">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6B2"/>
    <dbReference type="InParanoid" id="A0A1Y2B6B2"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000008">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY30007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="186" mass="19787" checksum="80E989C2ECE4AFD2" modified="2017-08-30" version="1">MMMRSTIRATSMLASTSFRPASSAIIGRPTTAIATQMVVKRGYHEKVIDHYENPRNVGNMNKMDHDVGTGLVGAPACGDVMKLQIRVNDDGIISDVKFKTFGCGSAIASSSYMTERVKGLSLADAGLVKNTDIAKELCLPPVKLHCSMLAEDAIKSAIKDYQTKRAKRLAMASGPTIQAGAAAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6T5</accession>
    <name>A0A1Y2B6T5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative O-acetyltransferase CAS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_528688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6T5"/>
    <dbReference type="InParanoid" id="A0A1Y2B6T5"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="10">
        <location>
            <begin position="387"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="832"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY30551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="979" mass="107806" checksum="83D280D51835322B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B798</accession>
    <name>A0A1Y2B798_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_529300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B798"/>
    <dbReference type="FunCoup" id="A0A1Y2B798">
        <property type="interactions" value="794"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B798"/>
    <dbReference type="InParanoid" id="A0A1Y2B798"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001189">
        <property type="entry name" value="Periodic tryptophan protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="436"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY30347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="570" mass="62395" checksum="995F49009BC6FC57" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7R9</accession>
    <name>A0A1Y2B7R9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_558455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7R9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7R9"/>
    <dbReference type="InParanoid" id="A0A1Y2B7R9"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="193"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="647" mass="71295" checksum="B0A730BC5B15F4DE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B855</accession>
    <name>A0A1Y2B855_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_527684</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 17">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B855"/>
    <dbReference type="FunCoup" id="A0A1Y2B855">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B855"/>
    <dbReference type="InParanoid" id="A0A1Y2B855"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="14">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="318"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="488"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY31009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="590" mass="65206" checksum="A3250DC51503BFF7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B870</accession>
    <name>A0A1Y2B870_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_103586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B870"/>
    <dbReference type="InParanoid" id="A0A1Y2B870"/>
    <dbReference type="OrthoDB" id="2596840at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="333" mass="35797" checksum="DA80338AD0A7DFF8" modified="2017-08-30" version="1">MPLHSVPIIIGTTIALVGSGYAFKKFIYDPHLAPLLEALLAAHSGNALPTPRHRRPSHSYESIPIRAQAVGATTARRDHQTNVRRRSAGRREALDVHELREPLISGRSTHPVIEETAVLLDEHNAMEGSPRRGKTADLIDLSLEDAEVREVVFNIPTPIESRAASPPPLATSSIQLSTPESMSKVSPSQASRSIHLPPEVPSTTFSFLSLSQASSPDTAGHQMPLSPIGRLLSINADRSAWEDDVISIHTSTSGYEDAEAYSPISGAMSPARLHASPRIEAVQELGLRFVSPEDLDGVAARRGALSVISMSDDEGWGADSDWDGARSEAEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8D0</accession>
    <name>A0A1Y2B8D0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_104452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8D0"/>
    <dbReference type="InParanoid" id="A0A1Y2B8D0"/>
    <dbReference type="OrthoDB" id="2575102at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36029" checksum="8699780B9AA5A649" modified="2017-08-30" version="1">MHLILPTSSMVATLVDQPACLPWSIIDYDPHSNSLIPPPSLFVMRLEGQFLDQVFTSFSSELSDPIGVLSTESPWSDFLRTAQQLHVSAGSRHSFLGWALIRVNWLNIIHRAPLVNHPLLAASSWSIIARAASHILRVYYDLAITDSLYPCWVQLRRIVICTQLAVLTCDHGHLHQVEAGELLSIGIELVRRHEIVWETARSTRIGLESARDRLLSSVYGVVVGPQMATVLQDAVSSEATRPMLPIHLHQTDPDQGVVTDITAPSSIDNNVSHGNGTWHSGFGDWQELGIDWPELWTGAMSDMKEVTVSGAAAGQLAQVNLDELFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8X1</accession>
    <name>A0A1Y2B8X1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_504904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8X1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8X1"/>
    <dbReference type="InParanoid" id="A0A1Y2B8X1"/>
    <dbReference type="OrthoDB" id="2593363at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="181" mass="18648" checksum="3DAB97007F56C450" modified="2017-08-30" version="1">MGRSKPRTNKRPPPKPAKVSASAPSQTPATAPLQPSNTNLPYLAPPQAFDLSSFVPPAAAVNPSDPSFPSALHSWSTSTLSRLGNLPKLTPSQLSAIAGAAAGIGEGGTGGAPIDLPASLAALFEAKLTLDREKAKLMRMQKELKGYRDGVAQVQGSVANGKGKEVVIDEDLGECTCGRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B924</accession>
    <name>A0A1Y2B924_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_527136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B924"/>
    <dbReference type="STRING" id="71784.A0A1Y2B924"/>
    <dbReference type="InParanoid" id="A0A1Y2B924"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="50"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="472" mass="51776" checksum="DD059B18C57F1266" modified="2017-08-30" version="1">MGGKADSPSIKSMFTSRTGPDGSERYGFFAPELANARKEWAKVTAIAFTMITVCMFGLLSIYFGSYYQQIPRAAHFSVQIIDLDSIASPYGSVAHPAILGPAVRQAASTALGSEPHLGWYEADTATLQNFRLTETGQGLDAYEYGMKIVTDQDVWAVIIVNANATSGAWSAITSGTEWDPSGAITFIYEEARNFYGTDQYVSRLTTDLLTSATGSAATTLASQVLALGNASAVLGSAAQGSISGAFAYNLVTIHPFDQLAGIPATTVGTIYLIIFTFLISGSWNNLGLPIIQDKLALGSEIAIKILVPLGAYLWLSLHYSLVSLAFLVDFTRKFGKGGFVVYWMADWITMSALGFVMETFFLWLGPWFSFFLVFWVVLNVSVAFLSIADAADFYRYGYILPVWNLVDMAKSIIFATKNHLAQNFAVNIGWMLVWMIILTVTVVVQRRKKEAVRMKAKWEEMKRLDGERGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B934</accession>
    <name>A0A1Y2B934_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_113636</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B934"/>
    <dbReference type="FunCoup" id="A0A1Y2B934">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B934"/>
    <dbReference type="InParanoid" id="A0A1Y2B934"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PEP5/VPS11 N-terminal" evidence="14">
        <location>
            <begin position="20"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="10">
        <location>
            <begin position="458"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="1007"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting protein 11 C-terminal" evidence="12">
        <location>
            <begin position="1047"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY30605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1097" mass="120323" checksum="5FB68300F77E57D0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9P0</accession>
    <name>A0A1Y2B9P0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_504799</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9P0"/>
    <dbReference type="FunCoup" id="A0A1Y2B9P0">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9P0"/>
    <dbReference type="InParanoid" id="A0A1Y2B9P0"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="17"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY31406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="553" mass="61169" checksum="D409561FFDCA9C3F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9P6</accession>
    <name>A0A1Y2B9P6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_450231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9P6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9P6"/>
    <dbReference type="InParanoid" id="A0A1Y2B9P6"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="196" mass="21978" checksum="651A7607989520C9" modified="2017-08-30" version="1" fragment="single">NRRLTKKTIKGKEGLHPGSRKAGQLTRVHLRTAKLQSQAKARKEANASKVQRPLFFYNSLSSPHPLTVPSLKALVALVYLTRYDTRIEELVAERRPGRPKAKELSELEEVKARETKEYETGLEVPDLTHPPTTRLLHGMLSAGSELTPAHIDLLRFVRVFKDSDQVEVTRPGRTGKMGLGGDKLLPGDERLGEDWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9Q2</accession>
    <name>A0A1Y2B9Q2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_526866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9Q2"/>
    <dbReference type="InParanoid" id="A0A1Y2B9Q2"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="98" mass="10752" checksum="FB29CFE2202A26B3" modified="2017-08-30" version="1">MAGSLYLVATVHAAPGQIDNLLKHIKGIRDYALSNEKGTLTYIVTQSVDDKDSVVIWEEYTSSATHEEHTNGELFKAFLAESSTLLDRELNVTILSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAG4</accession>
    <name>A0A1Y2BAG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trehalose transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_571955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAG4"/>
    <dbReference type="InParanoid" id="A0A1Y2BAG4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="60"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY31075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="546" mass="60533" checksum="754F3B7BA7E2C78E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB38</accession>
    <name>A0A1Y2BB38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_524636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB38"/>
    <dbReference type="STRING" id="71784.A0A1Y2BB38"/>
    <dbReference type="InParanoid" id="A0A1Y2BB38"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY31926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="368" mass="40028" checksum="A893A0B3C6862029" modified="2017-08-30" version="1">MSRPGPSAGSSRNPSAGIATPPDPNQIQDVYRPLAAQIKKPLTEYLPPGVTQPPPLADLLSLDTTTYASRLAGKTFLLSQQEAGSGSTSSLVKGKKRNRGDPALRQRVREETEGRQRDREELGVEGIRKARKRTGGGSVTKRGAIIDYNALKPLYHLHIIYLSTLLNLPPLPVPLPQPLPTLPNGLSADSIHSKLVKADFTGIHLSILSSRCPSLISLAGIVIEETASTFRLVSPDNRVRIIPKDGTQFQLSIPAYAPSMPEPSQDGEMPDSPDMEGFLASCPRLEMTLLGSAFGFRSGDRAGRKFRPAQGEDGSGWGFEWLRGEWKDTLDLVDSPKEVHPDEKGKGKKKRGKARRKDPPAWGALQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB77</accession>
    <name>A0A1Y2BB77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Pol II transcription elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_58080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB77"/>
    <dbReference type="FunCoup" id="A0A1Y2BB77">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB77"/>
    <dbReference type="InParanoid" id="A0A1Y2BB77"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="564"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="970"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="863"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116752" checksum="25F4AF04127DB7AE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBI7</accession>
    <name>A0A1Y2BBI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transferase family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_557835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBI7"/>
    <dbReference type="InParanoid" id="A0A1Y2BBI7"/>
    <dbReference type="OrthoDB" id="2581980at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52372" checksum="158D212104EC0725" modified="2017-08-30" version="1">MSETQFVAALAPDNPNLPEDIISIPIQPISLWPISSIPSVLVFPHELQLDRLVNAIQRVSAVWPTIAGRYVRRPRPGQPDHADFSIDLTRSSIPLTTQSIHAETAFPTKHVVQPTLAPYLDSLHPQYYLPNIDCPLLLLRLTTLLPSRRSVLGIMWAHILGDAGANAMFIQLLSSLYAKDQSTKLDPSQAPTFFPHISMPHYPPSDEIREKYRIRQITPTLPAPKQREAYANFGNGTEPVRASLSRKELSAMTIECATEASERISTQDVLSAWWVGVLQRAGFKIDSLIYTISYRTLHRQSEFFPSSLPTLAGNVAQMLKIQLPAPQAINTAHPAANTASMARAIRSALNELRTDPQKTIDWLSAIAYSLEQSALRDEGQVVVSGEGEALVNSNLRFNWNIPFGFRWDQTAFHTAYSVVRSLRVFQANPNEGQQEGETDVELIFNVPSNGGAKTSIEQIIEEDKRRWAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBS7</accession>
    <name>A0A1Y2BBS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_524435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBS7"/>
    <dbReference type="InParanoid" id="A0A1Y2BBS7"/>
    <dbReference type="OrthoDB" id="2306919at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="169" mass="19434" checksum="661B24E67B8FE4BD" modified="2017-08-30" version="1">MFSRSLPSQHLYRTFTFKSFSTITMTTIDSVQSKLFARPLPPLEPGKTVWDPALTSQISDLKAHQFVKAALHLANDDIKRCHDVTEKNQGDPTADVLHAVLHRREGDYWNSKYWISNVSSHPLFPSTSSAKKFVDSCESVKPGSDEEKRLRETQWEELKRIVVWTRENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCL8</accession>
    <name>A0A1Y2BCL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_378169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCL8"/>
    <dbReference type="FunCoup" id="A0A1Y2BCL8">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCL8"/>
    <dbReference type="InParanoid" id="A0A1Y2BCL8"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="216" mass="24173" checksum="A8EDFB69AB22B394" modified="2017-08-30" version="1">MVNIRNIELLNNPAKFDDGYHFRIKFEAVAPLAEDLEWRLIYVGSAKSEEHDQELDSCMVGPIPAGINAFEFTAPSPVHNLLPSQETEEILGVTVIIITASYRDKEFVRVGYYVNTYYEDEEMKENPPAVVEWDKLFRNVLIEKPKVTRFQNPWDSAPVPNAFDGFSSQPQSFDPPPQSQDGSSYMLDSAPLPPPVQKAPPALSNGGMDVDNPMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCU8</accession>
    <name>A0A1Y2BCU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_597802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCU8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCU8"/>
    <dbReference type="InParanoid" id="A0A1Y2BCU8"/>
    <dbReference type="OrthoDB" id="6288785at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1172" mass="127512" checksum="314C3AF5077B1D48" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDL2</accession>
    <name>A0A1Y2BDL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_522349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDL2"/>
    <dbReference type="FunCoup" id="A0A1Y2BDL2">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDL2"/>
    <dbReference type="InParanoid" id="A0A1Y2BDL2"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="453" mass="49752" checksum="B9A7101D3BA92DE8" modified="2017-08-30" version="1">MSPVAVQDAKPVANGKAKLSTVDVMQLEQEYSAHNYHPLPVCFERGLGAHVWDPEGNEYLDFLSAYSAVNQGHCHPDILNTLISQAQKLTLSSRAFYSSNLGPFAKKVTSMFGFDMVLPMNTGAEAVETAIKLARKWGYMKKGIPEGKAKVLSVEGNFHGRTIGIISMSTDPESRTGFGPFLEGVGPKWDTGLIRYNHPEDLEKVLEKHGDEVAAFLVEPIQGEAGIYVPDDGYLAKCKAICEKYNVLLIADEIQTGLCRTGKMLCYEWDNIKPDMVILGKALSGGVYPVSCVLASKEIMLCIKPGEHGSTYGGNPLGCAVAITALEVLERENLAQRSLELGELFRSELKALNSPYIKIIRGRGLFNGVVIDEKQSTKGRTAWQLCLLMKSKGLLAKPTHVNIIRFAPPLVISEEDVRKAVRIIGESLSELDTLEHIPGDEHEDHDTKIELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE05</accession>
    <name>A0A1Y2BE05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_520995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE05"/>
    <dbReference type="InParanoid" id="A0A1Y2BE05"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="384" mass="42061" checksum="83FF144D72F0063A" modified="2017-08-30" version="1">MKLNKGIRLSGSTPAGHALRRQRDPVRFTAMCLMAVSNAVTVTSRLHFADQSTVAMIKHGSPCDMEVHFRESHSQEVPIDSNMVCSRLVCSSYYPDRLDISPVVGGILLSVSAGISTIWMILCVVLAWIDLASVQSAVDGLTIINQRFKRRDLLPSISTNNLSGFLGVASAITFTAANYPQPQTLSSFLVIILATCSSLGWIDLETADDLVPKAIDCLTVVVTAILVMDKSTSYEGEWYWYHDPNLYCLIALSMEASCGMAGFWAFRAVSRPFRADSRPFRANSSPEMSRENKRHAITNSKAALPARILLVIVLGTTLASFGLCARAVIGDIRPYTIGFGLVLCTLLTSAALSGVILRQSFKRYPLWFPGKYPHPYNQVVGTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEH0</accession>
    <name>A0A1Y2BEH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_521225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEH0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BEH0"/>
    <dbReference type="InParanoid" id="A0A1Y2BEH0"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="133" mass="14185" checksum="52E0560F9F55C266" modified="2017-08-30" version="1" fragment="single">MSTSEPIANGHSALASSTASLPAITPPPEIEATLSRLSAYRNVKGVMIISRRETESSGHIGAIVQSTGAIFDGEGGRRYARALESVVANVAGAVGECDDGDELRLMRIRTKRHELIITPDEKYLLVVLQDPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEY1</accession>
    <name>A0A1Y2BEY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_520743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEY1"/>
    <dbReference type="FunCoup" id="A0A1Y2BEY1">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEY1"/>
    <dbReference type="InParanoid" id="A0A1Y2BEY1"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="118" mass="13432" checksum="705E0C454B7CAEBD" modified="2017-08-30" version="1">MKITRHAVISRLPFCSSYTLPPRYSTYIPKMSASQVPQFDAATKKELEEFLEQEQSKAKLQATVHELTNTCWKTCITGSIGAKFSRSEASCLENCVDRFLDSSLFIVRQIEAQKNQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF16</accession>
    <name>A0A1Y2BF16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_521385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF16"/>
    <dbReference type="FunCoup" id="A0A1Y2BF16">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF16"/>
    <dbReference type="InParanoid" id="A0A1Y2BF16"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="509" mass="55317" checksum="0128AF2101B64951" modified="2017-08-30" version="1">MDEYPLKALQRSMSPDPDDTRRRLLSDNEDVNRRYSGEDAELDGEDIDDLIAAHDTLPPSAKHARTRLFVAFLIFGLLNNVLYVIILSAALDLVPASTPKGVVAFFNILPALLTKVAWPLISNGQIQYGRRVGFCTCCSWSGIIIIALSSGLWPRLFGISLASLSSGLGELTFLQLTTTLPTRTSSKTALGAWSSGTGFAGIAGAGLWWLLRGLGVKRGLGISSLLPLFFPLTYLVLLPPVAHLKDPSTTTYAPLPNSIIPESITPTSIVISLPGSEAGHRDSKRVEVRLTTSEKIELLKPLVVRYMVPLCAVYVEEYVINSGVAPTLVFPLPTSGIWSTLFKSPRDYYPFWSLTYQTFVFLSRSSLSLGLPAIPLGLLPIPTIVQFIILTLLSLQASNFIFSSTSYTPPSDPPFAGVDRSITIVFLLMCLEGLCGGSSYVNTFYHVGREGEESDQEGLKQKMEKEFRIGAVGAADSCGILFASLISMPVEVALCNAQVNRGRSTCREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF30</accession>
    <name>A0A1Y2BF30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trehalose utilization-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_300250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF30"/>
    <dbReference type="InParanoid" id="A0A1Y2BF30"/>
    <dbReference type="OrthoDB" id="3482285at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012463360" evidence="3">
        <location>
            <begin position="23"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ThuA-like" evidence="4">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="365" mass="38332" checksum="3C494BFDF1484BF3" modified="2017-08-30" version="1">MLSSTLLVHLLGLFALTTNALASSPLVLVYYATAGYYHDSIPTGLRVLGEQGPLYGISFDFTEDKTQFRPEILTKYDAVLFFDNTDQVLDETGEAALKAYFEEGGNFVGIHAASSCEWDDRRFSLAIGALFDYHPTLQNVTYVNLDSNFPATKYLPTKFRYEEEAYHFQSDPRENGAVVVLALDPDSFYNDGTSSGNYSGGGHPLPAAWYNESPLSAKPLAQGAPVSGRSFYTALGHSNRTWESPWYQGHVMEGIKWVLDGNSTLAYGVGLVGNPIGTATASSSGASVSSTQFSARDAGALVATSSTSASTGTNTDTSTSTGTSYSSAATSSSAAMGKSAVLGGAGAGIIGTVLAGIVAGVGLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG06</accession>
    <name>A0A1Y2BG06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_592698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG06"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG06"/>
    <dbReference type="InParanoid" id="A0A1Y2BG06"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="481" mass="54889" checksum="F2AA32346AC67370" modified="2017-08-30" version="1">MGDKSCSGWDPSLDPEIDPPSCLKARQYRQVSSVLAREEEGKHPHWSFTTNHNLETLRRLLNCYLPTSHVNYTTCPDRPLVVSGYWYTATILNGETSGEGIWQRYLVKEIEDLGYFWIAVGPYENWVTVAEMLPDVYRILWNWQREIISCFTDPRCIAKDHYVPPEDAPDLSLDVPDEERGVIPLWALNVIDYWGTRPKERSHNDYWWGTSGKGEWSYQPLGQEWIATPWALPGGHFHLPYSMEEECLNLPATPHAARSDHVLILAKRSSYFDHGYSPPREYFTRLSQEPGFHLISAAQVEEGHPLPEGLNSIGVQKYEKYSEVVGGVKVMLGIGQPTISPSIYAALCQGVPAVLPYFDKEPILEGWSVFAGPWQHGPASLIGPPYVYSYYNKNYTMMLESIQEAIKTPIERYIPDDMKPAFALSKMSEYLERDLQGMFRDKLLKNGGQVPRLIGNARERCIELKHCTEGFPAGRKPFRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG74</accession>
    <name>A0A1Y2BG74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_504056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG74"/>
    <dbReference type="InParanoid" id="A0A1Y2BG74"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="190" mass="21039" checksum="4EBE2C9942EBC5D2" modified="2017-08-30" version="1">MTSSTKDTDLAPAQESTIFSELTTPVDHWNSSENDSSDSNDDDDNRRRRGSLGGVSKRRSRPTSPVQSTERMMGRDNPATKLLLLLSRYGGAETAVQESEGEGENTSMMQQESQTNQTQQNILVSTLGERVRTWVKSGDHSGARRIFPLLGLVGIKEEEVQDMKASVGYVSDDEHHDDFLGFDDLNVKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGX7</accession>
    <name>A0A1Y2BGX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_518285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGX7"/>
    <dbReference type="InParanoid" id="A0A1Y2BGX7"/>
    <dbReference type="OrthoDB" id="2574956at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="301" mass="32489" checksum="0E77758CE5DFA0A3" modified="2017-08-30" version="1">MTTPEQHARSNTSLTPIAIHSTPTSHAAPVSTHPKLRYPYPLALLAILDLFYTLHHASKHRAAPHLIGLSIIRAGVLIIGLGSSRLWRQRGVWLGLASGISVGAVVWEWCVGQLRKSETGEADVQSRAHASFLGTTILISTIEYLCFLVLLRLSPAPGLSLRDSIQSPTGYSFRTSATPPSQSQDSESDPEMGFTDPEDDDVSSVSDSSIIDLPPPLSPSRIVPPHSLSMNGGLNLAALDDTPVVGHLVRRTRSARFLGRSWGSRVGPEDDDDDQGEGEELGRTAQNRGTREEDYGTFGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGZ3</accession>
    <name>A0A1Y2BGZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGZ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BGZ3"/>
    <dbReference type="OrthoDB" id="2574468at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="245" mass="26530" checksum="4AF3382A69E8C317" modified="2017-08-30" version="1">MTYQPFFSTMAQPHASGSSFKTKRKYVDDEEQNDLDQDKGKQMRMCSPPPFHRNTTFPPPDLMADHSASASDEDQAMDMDMDGDRDEVEHDGYGPGNTSPSIRDGEALYTFGGGGSGGFGFGPGAEEDEDMEEANIKSMYPSLTPHPNPNHFSNHPSHSPNSPWSAQPFTTSLRPVASPIRGVIQPSIAAPLPENASEIEKARATHGPQCKSIPKLVVSPYPDAVTGERSMWSVCQDCGAAERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH12</accession>
    <name>A0A1Y2BH12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_233931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH12"/>
    <dbReference type="InParanoid" id="A0A1Y2BH12"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16493" checksum="6F0B080A138E5E1D" modified="2017-08-30" version="1">MSPVPQQKGRTIQWPDNPHSMPQYSRLSVAEIDTTRLIVDLYETIHAQNSWNLMTGLFILCVGFALGILVFASVHDLVLHVNGCYGRERESTTSETRSCEHQHHLHGEKESVEQALALVSVNTIDEKRGDTLDEEELVVLTIGRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH37</accession>
    <name>A0A1Y2BH37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_518571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH37"/>
    <dbReference type="STRING" id="71784.A0A1Y2BH37"/>
    <dbReference type="InParanoid" id="A0A1Y2BH37"/>
    <dbReference type="OrthoDB" id="3199651at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="219" mass="23028" checksum="68AC9B9459AE758E" modified="2017-08-30" version="1">MSTPEASSTRQRTSRLDEEPERKTSNPASLSNDPNKQVHRNKPVVKPPFADVTMGKFLTYLVLFLVAIAAFYTYRFTVWAADAGGYWNLVTGRRTSPQPGAVEFAAKVAERAQSAGSTANSYPGSAVGGGGSGKPTKQGTDVQSQIYNLANALGIKPAELSDAIRPLIDPSAPNAAEKAQQEVEILKAQLAASGAAAGGEKEEQPQGSLLGLVGEVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH72</accession>
    <name>A0A1Y2BH72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_520193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH72"/>
    <dbReference type="FunCoup" id="A0A1Y2BH72">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BH72"/>
    <dbReference type="InParanoid" id="A0A1Y2BH72"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="41"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="198" mass="22569" checksum="31B8E90520582E22" modified="2017-08-30" version="1">MHICSSLINPLYQTVQRPLSNTLSRTFIKMASTTSDPSTYRFNHTMFRIKDPKVSIPFYEKVLGMELFNESPGSDFTNFFLAFPCGFGPDADKMSKEEKANVQMAREGVLELCWNHGTETDSEFKGYVSGNEEPGRGFGHIAITVDDLQAACKRFDDLGVKFKKRPEEGRMKHIAFIYDPDGYWIEILNNSRRSPDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHN7</accession>
    <name>A0A1Y2BHN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_477258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHN7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHN7"/>
    <dbReference type="InParanoid" id="A0A1Y2BHN7"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="488" mass="52838" checksum="A00C97CADD46795E" modified="2017-08-30" version="1">MAGGAVLVGQSSGKPYGNPLRKGFIQREYLWAFMLVTSLFFLWGFAYGLLDVLNKHFQNTLGITKLQSTGLQVAYFGIGYFAYSPLAGEIMKRRGYKFTIIMGLGLYSLGAILFWPVAKFSVNTTNPHGIFGGFVVCTAVIACGLATLEVAANSYVSVMPPHQVANFRLQFSQSFNGVASFSGPLIASKYFFSDGNSNNLTNVQWVYLAVSGMGLLVATAFIFSKLPEVSEEALQAEAEALADAQGHDTQASKPFYRQYRAITGFVAQFLYVGAQVTIGSFFLNYSHENAGIADSRGSQLLSYGLITFTVARFIGTALLSVIAAPVILAVYAFACIILALMIGSLHGMSGVICLIIIMFFESIMYPVIFVLGTTGMGRHTRRAASLLVMGVSGGAVFPPIQGAIADKFDTRTSYYLVVPCFVYICGWAIYIWNKDGRRWTAGGGEIEREVEAASGGVIPPAHVGLSYTGHQENYESSIKEDVTEVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI19</accession>
    <name>A0A1Y2BI19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_516713</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI19"/>
    <dbReference type="FunCoup" id="A0A1Y2BI19">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BI19"/>
    <dbReference type="InParanoid" id="A0A1Y2BI19"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="530"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="612" mass="66654" checksum="F231535CDF940E1B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI80</accession>
    <name>A0A1Y2BI80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_517417</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI80"/>
    <dbReference type="STRING" id="71784.A0A1Y2BI80"/>
    <dbReference type="InParanoid" id="A0A1Y2BI80"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="37"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="389"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="737"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="942"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY34280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="997" mass="108676" checksum="7F4AE99A8EE5F7A2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BII9</accession>
    <name>A0A1Y2BII9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_513615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BII9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BII9"/>
    <dbReference type="InParanoid" id="A0A1Y2BII9"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="914" mass="99770" checksum="46639C15F0874AF1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIP8</accession>
    <name>A0A1Y2BIP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_513904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIP8"/>
    <dbReference type="InParanoid" id="A0A1Y2BIP8"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012011058" evidence="3">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="88" mass="10006" checksum="3A9EFAE4F40C6401" modified="2017-08-30" version="1">MAMNVSFFLLILTLFALAFLTKWNQHVLIMLAVTTCLWAAMVWFVLEITKVQTRPDNMPLSGDLLPASEPDPKPETEIQTEAEGRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ85</accession>
    <name>A0A1Y2BJ85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">BCR39DRAFT_515038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ85"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ85"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ85"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="422"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="504"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="788" mass="85769" checksum="299BB78A4A16D2DD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJF3</accession>
    <name>A0A1Y2BJF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_517260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJF3"/>
    <dbReference type="FunCoup" id="A0A1Y2BJF3">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJF3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJF3"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="292"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="355" mass="39412" checksum="63FCA7757FABC938" modified="2017-08-30" version="1">MSFFKRNKESLAIPPVAQPSEPKADPYAARSTEKQSDPYARNGTPVGGDPYAKKGAAGGGGGGDPYASSAAGRDPLGGKSNPYAKAVDPADQARNELFAGYNAPEKPQSDRKLGYDGREEEPDFDPDEEAEAIKSGMRELKQDSLASTRNALRLAREAEDSARGTIAKLADQSESIANSERYLDKAKANNLRAVDKADELKQLRRSIFRPVVVWNKDAKRAAQEQKIDERHTMERADRAKALEDISDTRQRLGQATNPSPYGRSERAPMPGEQKARRDARARYQFEATASDDELEDELDENLDETHEVVKRLKNLAQGMNSEVTKQNTRLTRVTDKTEDLEYGLEKTTDQLRRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL40</accession>
    <name>A0A1Y2BL40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_510130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL40"/>
    <dbReference type="InParanoid" id="A0A1Y2BL40"/>
    <dbReference type="OrthoDB" id="2596551at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="678" mass="75928" checksum="A1191607EEC29BC6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL97</accession>
    <name>A0A1Y2BL97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_510476</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL97"/>
    <dbReference type="STRING" id="71784.A0A1Y2BL97"/>
    <dbReference type="InParanoid" id="A0A1Y2BL97"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="353" mass="36560" checksum="4DAD43D26AE65D2F" modified="2017-08-30" version="1">MGLVLLLAQCVCMFVASFLCGSLPLMFKSAMSGLRLKAISVLGMGLLVGAALTIIIPEGVSTLYDSLPNDGRDHEEATIRAVGLSLLSGFALMLLIESLTPHPPHSPPSSPSSTPPTIHTPLTAISPDRRSLESGRPSPHHLNSSSPMIPKRMHVSDVDESGRKNPHPQGGVQGLNATLGLVIHGAADGIALGASSLSGSGSLGLVVFLAVLVHKGPTALGLTTTLLGLSLSPPQIRRRLLIFSFAAPLGAILTYLLVRVFGGNSAGGQHDADGLGWWTGIALLFSGGSFLYVATVIQPLSAPSPHSHTHSHHTSADLGEENDPPLGKYLRTGMLVGGMIAPVILAALVGDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM15</accession>
    <name>A0A1Y2BM15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_511681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM15"/>
    <dbReference type="FunCoup" id="A0A1Y2BM15">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM15"/>
    <dbReference type="InParanoid" id="A0A1Y2BM15"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="111" mass="12610" checksum="C7179E3AC1E6B9CD" modified="2017-08-30" version="1">MADVEMSSAPRTRSNIRNGANKGHPTTVIPKKVRPSNKKGVKTEKKTFVKSVIREVAGFSPYEKRVMELLRNSKDKKAKKLTKKRLGTLLRSKRKIEELSNIIAEQRRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM53</accession>
    <name>A0A1Y2BM53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_511919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM53"/>
    <dbReference type="InParanoid" id="A0A1Y2BM53"/>
    <dbReference type="OrthoDB" id="2564972at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="67066" checksum="865C03ADE7C5B03D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM76</accession>
    <name>A0A1Y2BM76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative GTPase activating protein for Arf-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_512658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM76"/>
    <dbReference type="FunCoup" id="A0A1Y2BM76">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM76"/>
    <dbReference type="InParanoid" id="A0A1Y2BM76"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010989673" evidence="7">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="535" mass="58739" checksum="4FFDAD1347453E83" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMB1</accession>
    <name>A0A1Y2BMB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_512857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMB1"/>
    <dbReference type="FunCoup" id="A0A1Y2BMB1">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BMB1"/>
    <dbReference type="InParanoid" id="A0A1Y2BMB1"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="120" mass="13451" checksum="80012560CDA6EB5B" modified="2017-08-30" version="1">MSTAAKRRLIRDFKRLASDPPIGISGSPNPDNIMIWNAVIFGPPDTPFEDGSFRLTLTFTDAYPNKPPTVRFVSKMFHPNIYNNGELCLDILQNRWSPTYDVAAVLTSVQSLLNDPNPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AD05</accession>
    <name>A0A1Y2AD05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_475040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000137">
        <property type="protein sequence ID" value="ORY20386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AD05"/>
    <dbReference type="STRING" id="71784.A0A1Y2AD05"/>
    <dbReference type="InParanoid" id="A0A1Y2AD05"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="168"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY20386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="496" mass="55113" checksum="E370C60D406E19DC" modified="2017-08-30" version="1">MPPRRKAAGDGSAIVTPSTSQTVSTASSRRKSGVKTNGYTLEHTYDSVGQKREVLVINDSESPAVALPPRKRTRAQVAAEANAVANGHTTNGSASLTASGSIKKRKVDEASDAGSAKKAKTKTHQASHAPPLPTPKQNPAATGPGQPGWDDAEGHYIVTPDDVIAGKYRIVRLLGQGTFGKVVEARHIETRRKVAIKVIRAVQKYRDASKIEIRVLETLKRNDPLNDNKCIHLDEYFDYRNHPCIVSELYGMSVFDFLKQNAFAPFPEAHIQDFAKSLLKSVAFLHSLKLVHTDLKPENILLCTNEARQAGPRVKGSKAKRILRNTEIRLIDFGSATFENEYHSSVVSTRHYRAPEIILGLPWSYPCDLFSIGCILVEFYTGEALFQTHDNLEHLAMMEIVMGKMPQRMIERGRAKKPEFFKGLKVDFPNPSVSKSSRKYVKSLKTLKEIIVPNSKHNQLFLDLIVRLLDFDPDTRITVTSALRHPYLALDVPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADY5</accession>
    <name>A0A1Y2ADY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_474910</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000127">
        <property type="protein sequence ID" value="ORY20706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADY5"/>
    <dbReference type="FunCoup" id="A0A1Y2ADY5">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ADY5"/>
    <dbReference type="InParanoid" id="A0A1Y2ADY5"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="68"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY20706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="492" mass="53786" checksum="033ED55FDF2BA17B" modified="2017-08-30" version="1">MCPTPLPTTNGHANGHPTEEMVAIDTSAPALPPSLNETSSTPQAPPSVKSHKGLYARPSDFLSNTSNWKIIESTLREGEQFANAFFTLETKIKIARMLDDFGVEYIELTSPAASPESKAHCEAICKLGLKRTKILTHIRCHMDDARLAVETGVDGVDVVIGTSSFLREHSHGKDMTWITKTAIEVIEFVKSKGIEIRFSSEDSFRSELVDLLSIYRTVDKVGVNRVGVADTVGCADPRQVYELVRTLRGVVSCDIETHFHNDTGCAIANAYAAIEAGATHVDTSVLGIGERNGITPLGGLIARMMVADPEYVKSKYNLPMLREIENLVAEAVEIQVPFNNYITGFCAFTHKAGIHAKAILANPSTYEILNPSDFGMTRYVSIGHRLTGWNAVKSRVEQLDLNMTDEQIKDATAKIKELADVRTQSMEDVDMILRIYHKGIHSGDLKVGQSAVLDKLLEQHMPSRDSSPNGKANGVNGNGTPAKRQRIEEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE03</accession>
    <name>A0A1Y2AE03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial F1-F0 ATP synthase subunit F of fungi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_474992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000133">
        <property type="protein sequence ID" value="ORY20510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE03"/>
    <dbReference type="FunCoup" id="A0A1Y2AE03">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AE03"/>
    <dbReference type="InParanoid" id="A0A1Y2AE03"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="100" mass="10804" checksum="6056A82E9D589710" modified="2017-08-30" version="1">MFSSAARRSLANLIPPKIATPSAVSSGSTSQRTANVIEFYSKLPKGSLPDSQRAGGIRGRYFEGKNASGFPIVATVLSLIVVGYTLDYHMHLKHHKNGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFC0</accession>
    <name>A0A1Y2AFC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_569933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000114">
        <property type="protein sequence ID" value="ORY21298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFC0"/>
    <dbReference type="InParanoid" id="A0A1Y2AFC0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="354" mass="38158" checksum="5F9B1F348E4FD868" modified="2017-08-30" version="1">MSRVSSTSSNNSPGKPQRSRPAPPSSTPDTTANPATPIVRPRHLKYLSFSDFVPGDSTTAQPAAESSAHNQSSSSSIVTVPSHQSIDQGATNPPKRSFWRTLWNSLHLGKESRQIVQTRSSASTPRASPVSTNPAGSAQAGTNTRYSSGTGRRAIMQLSSLRGAGSHIDTSKRSVPRSSAPASFTNRRPEAELMHWWVSQTETGPAWSPSAELRRASHLLAQQLVSQIGNARRDDRASMVKEFTNLVTLLYRSVHTTCLDSDQKNDLLRLVQLLNRTLDPIKPGTSLLDSFSKVPLKERLDSLESTITDVKGVPPDAPTVEWDEDSVGSPRASPSTGTSSRLPGPSTRSRGYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFP8</accession>
    <name>A0A1Y2AFP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_474576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000113">
        <property type="protein sequence ID" value="ORY21326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFP8"/>
    <dbReference type="FunCoup" id="A0A1Y2AFP8">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFP8"/>
    <dbReference type="InParanoid" id="A0A1Y2AFP8"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="4">
        <location>
            <begin position="127"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY21326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="222" mass="24584" checksum="BFA039E3B04F03C6" modified="2017-08-30" version="1" fragment="single">RIEQIQEVPLVVSSDIESTTKTKAAVELLKTLAAYADITKVSNSRKIRAGKGKLRNRRYRQRRGPLVVYAKDEGIVRAFKNVPGVETAPVESLNLLQLAPGGHVGRFIIWTEAAIAALDSVYEKKSHFILPTAKIATSDVTGLINSDEIQSVLRPAGQAVAKRPFTQKKNPLRNKAVLFRLNPYAKTLRRQELLRQERKSKAPVKKAADVAGKDFLDILHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGU2</accession>
    <name>A0A1Y2AGU2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_50554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000104">
        <property type="protein sequence ID" value="ORY21799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGU2"/>
    <dbReference type="InParanoid" id="A0A1Y2AGU2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="218" mass="23808" checksum="961E15FA036A7F36" modified="2017-08-30" version="1">MSSQCLIFPVPVRLLMYAILKMYGEFSLASDTVKYAIVLNESTIEEDGDEDASSAILFQRRATDIACTGDVITTDYAPRGLISNTSALVLALSVLERDEYLPPPYTPSPDLSTAVPERLNFRIGIAASGSGLRERTPGIRVTNEADIQRRPVDIDTGTPSEPPAAAAAAAAVRRSSRLSDHRFGRTQTRPVGRSFDEDNGVDEFSEDLFDLTRITTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHF6</accession>
    <name>A0A1Y2AHF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_552566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000101">
        <property type="protein sequence ID" value="ORY21946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHF6"/>
    <dbReference type="InParanoid" id="A0A1Y2AHF6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="531" mass="58934" checksum="A556B01B43031988" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJJ4</accession>
    <name>A0A1Y2AJJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CwfJ C-terminus 1-domain-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_473730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000089">
        <property type="protein sequence ID" value="ORY22686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJJ4"/>
    <dbReference type="FunCoup" id="A0A1Y2AJJ4">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJJ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AJJ4"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="618"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="750"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY22686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="878" mass="99142" checksum="3168B3F28E04D600" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK99</accession>
    <name>A0A1Y2AK99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_550255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
        <property type="protein sequence ID" value="ORY22961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK99"/>
    <dbReference type="FunCoup" id="A0A1Y2AK99">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AK99"/>
    <dbReference type="InParanoid" id="A0A1Y2AK99"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="31"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="490" mass="55353" checksum="7362E3E828DB217D" modified="2017-08-30" version="1">MDEGYEALFDDLRPAVDLTALCSLCAQGIPKHPRHLRALCYSLLVGSLPPEKAKWDKAREQNRRVYEDLVVRLSSDIEQSDDPLEPLSASDEKLRGIAHDVERLKLRGRLRPDCPRHSRAILKRIDRIGQGSRQQELGTRPELTLSPPPLSTPQLSLSLASSSSPITLLPSRQLISDTSIRSSAPSIGPADTAQESMTRLLFVLFRDRQYHSAIAEIIPPLYHIFVEDSPEEDMYHFLSRVMELAEEPNLQRLSYRVRWLDETLYQALCSRNLDPATPLYAYRWMTTLWVHDVPDFLPLWDYCFSQQDRVGAGLDICTAILVLTWPMISPHSKGFWGQEDDEGEEFVRAVQLLRGVRIPGKIIADKAKQIRDVHRKEGFDEMPYQAASTPPRASLQHRLTGLLGTPPSRSDAVLPRTLLLSSSARRASNSSNRAPSSIASPTGSTLTESLTDSPLYRIRSRQSNRSPRLSHTPDHSMARELEYEGSMHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKJ5</accession>
    <name>A0A1Y2AKJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_550633</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKJ5"/>
    <dbReference type="FunCoup" id="A0A1Y2AKJ5">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKJ5"/>
    <dbReference type="InParanoid" id="A0A1Y2AKJ5"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="304"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY22820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="420" mass="45611" checksum="2BE832375AA82A14" modified="2017-08-30" version="1">MSSTTTSTFTPLSLLPLPDKAQVNDAFVGRSLSSLRTPALVVDRGVFKENCERVTLEAERRGMRFRAHVKTHKTIEGTRLQATASHGVKAFIASTLPEVWSVVQSGLFTEDLANDILYSMPVSADKLEDLNDAQEKIGNKGVLRLMLDHPAQVAAIEGFNARFKRGAWSVFLKVDGGGRRAGAPPESEQMRSLIKACLASSAVDIYGFYSHFGQSYASTSLDKATAYYHSEIECVNAAAKVARSLGANGQFVLSVGATPTAHAATQTPEDSENLQGELELHAGCYCMNDLQQLATTLIDIDACALTVLARVVSVYPLRNEAMCDAGAIAFSKDTGPFPGFGRVVHPDRLTTWDVGRISQEHGTLVHRPGVEEDKIEQIDVGDLVRIVPQHACLVCAAFPWIYVVDGSDEVVDVWIPFKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKP7</accession>
    <name>A0A1Y2AKP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_550209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKP7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKP7"/>
    <dbReference type="InParanoid" id="A0A1Y2AKP7"/>
    <dbReference type="OrthoDB" id="2593364at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="497" mass="54155" checksum="74A66B686C8F1E9E" modified="2017-08-30" version="1">MRETRGSAARELEAPVNKRKRSPVPLKIVLPSPASLEEQEPKRQKISIKINRPKVKDALGQDVRAALALVIAQMAEDLPPPLNGILALSLPPKFEKTDENTLGYLLQQDNLTWDVLVNTLHTFSENLLVPCAYPNPMPSLSQFHLPIPPLPSHYPPHAIYNFCAALHSVMLQIEPHVSTTESERWALVQRQGGDWFTSSVDFRQKSSLQDLAAAGDKFGYATAVAVQSAIEKPGNPSSLSESLLRRASLKASRWKEARGSFGSVTRGVIIPPVTTASFTPGFAPTYDSTFSTGGFGYYSTIQSMHERTRHRQWSATVNRPLEFGYWGSPDTSTPLETNASLIAELHAWQGIRVRRGEQAPSDREQEIADALLSSLTDLVANTSPKDLVSSVNAHDLADRFLPVPSPVLRGTLDPKRPHAIHDNATLRPGVAARNAYPPAPGRPTPASPAPWPDPKSATTYTRPGPGPSRLSQSFRPNPYGLGARGPGTSPSMRPLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL35</accession>
    <name>A0A1Y2AL35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_473277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000081">
        <property type="protein sequence ID" value="ORY23261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AL35"/>
    <dbReference type="InParanoid" id="A0A1Y2AL35"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="8">
        <location>
            <begin position="1827"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="601"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY23261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1911" mass="212515" checksum="3CFD283D02FC209D" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALA3</accession>
    <name>A0A1Y2ALA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_550199</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALA3"/>
    <dbReference type="FunCoup" id="A0A1Y2ALA3">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALA3"/>
    <dbReference type="InParanoid" id="A0A1Y2ALA3"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY23060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="213" mass="22873" checksum="BEF41A98B0939DDB" modified="2017-08-30" version="1">MAVQFKGGVVIGADSRTTTGSYIANRVTDKLTHIHDRVYCCRSGSAADTQAVADIVHQHAQVYTAIYGEPPTVNTVAAMFEKLCYENKDQLSAGIIVGGWDKENGGSVYNVPLGGGMFQQPWAIGGSGSAYVYGYCDATYQEGWSEEETVNFVKNTLSLAMGRDGSSGGCIRMCVITKEKVERHFIPGNELPRFWEGKEVVGASAGMRVGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANV9</accession>
    <name>A0A1Y2ANV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_334588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANV9"/>
    <dbReference type="InParanoid" id="A0A1Y2ANV9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="234" mass="27251" checksum="2A3ED15B0348626E" modified="2017-08-30" version="1">MAMCLNLIPMPLNTSHMPLNNPNRRFRTVILRNPNRSRTVCHRAKVHRSNNLLISRRRLSPSLVLLKRKTSLEASTLKINTKARESVHSELQRVRLTSPRRARHDTIRSPEQLGSVLEQTPKRNTRQLGTLIMLLKPNNRLIQDSSTHCRTVVLFRLFSNLMERHHTHLSMVLKHSHSNSLMERQELEWLLLQMGWEGCLYMASKCTCMLLMTLYKGDMGRHAKAVHIRIEICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP46</accession>
    <name>A0A1Y2AP46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_323021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP46"/>
    <dbReference type="InParanoid" id="A0A1Y2AP46"/>
    <dbReference type="OrthoDB" id="2595104at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="490" mass="52247" checksum="DD0E1598AB4617C8" modified="2017-08-30" version="1">MFEEDFERCFICQQPCKGLYCSSECRMQDKGTPSPAIRAAGVRLTSQIPAHLSPLIRPLPHITPSPRMPAHLPAGSSASSSANSSPIQSPRTNPSADVSPQKEAFNLPPPAFPSHQVQIMAFPGSVPVKIPALVPRASPATQASPAPESHGSSMYPTGTSIDTLRFGRKPGVINSVTSPNALLPRCACGKPANHRSRTTSKDRGGLDSGFSALLLGPSLADDRVRSHRIVSDPAHFGNGRTKAASGLATPAEGYHTPSTTLSGSLLARSRSDPMPSSPKDRSVIAPMTSRVPATISPRRLSNDEDGRNSAILPALKRSAATSPTDVEISPLTSPRRGRSRERTRHRDESLSRGRLLQTIEREQAPSRSRHRREEAARRRSDERLPLPLPPIQMTSQMHLQTPLVEPAQIMPSWSKRTSSTDVKLAKGEGVVAPSARRSGGSGSGSGASSPRTAVDDAKGKSEAAITAERGRKAEELQRANAQLGQIFGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ40</accession>
    <name>A0A1Y2AQ40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptin N terminal region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_547823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ40"/>
    <dbReference type="FunCoup" id="A0A1Y2AQ40">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQ40"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ40"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="44"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="768" mass="84388" checksum="DDD6C98EB858440F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQB4</accession>
    <name>A0A1Y2AQB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_507370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQB4"/>
    <dbReference type="InParanoid" id="A0A1Y2AQB4"/>
    <dbReference type="OrthoDB" id="2563170at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021660">
        <property type="entry name" value="DUF3253"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11625">
        <property type="entry name" value="DUF3253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="161" mass="18290" checksum="9AFAA62EECF676B1" modified="2017-08-30" version="1">MTVDKPAKRVNKQRARQRSDHKVSSTKSPTTGRNHVRGTKRPSCPEVKLSAQAEKSTVAVDDEDKRKAIKKTMNDLLCRLTKAESTICPSQIPRSLHDSDRVTYPDWRGMMDQVRDVVWDQVREGRVQVTQGGVVRSLEEREGLKGPIRVRKGPEWDDSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARQ4</accession>
    <name>A0A1Y2ARQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2421 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_291018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARQ4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARQ4"/>
    <dbReference type="InParanoid" id="A0A1Y2ARQ4"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="2">
        <location>
            <begin position="126"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="362" mass="40315" checksum="2453F91170EC41FA" modified="2017-08-30" version="1">MPALAIYSGDTTAAWLGRVVASFWGCVLGMVAWYIGSGNGQGNAYGLGATCAVAFPVAMFFRIHFPGPVLTAVMLPVTFGLVIGYSYLNGTFVELTYASWGFDVAWRRFVSVLIGITAAWIFSYLPPVYSRKRAIRSSYATIIGVSGSLLCDILSYANNPHYHLQENVECRSNLLTWRSKLTKLAARHANAKLEYSLRGRWPEERYLALREILEDLLSLLAQFNHVLGQLDRPWRKALLDRTRFSDPIFLGDVLAVLTMCSSGLRAGTALPQITPAPLIERFRKGKYRGLELPHDPTDQSGEVPSLVTVDVLESENYMRYALGTTTTFSIMARLDRLVVTCKTLLGENYHVSGLHFERDLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASH2</accession>
    <name>A0A1Y2ASH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_560993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASH2"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASH2"/>
    <dbReference type="InParanoid" id="A0A1Y2ASH2"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="302" mass="33155" checksum="0F07DA49B2DBCB5A" modified="2017-08-30" version="1">MVRNIALNNGKTIPSLAWGNMGGKAKALKAGAIALKAGIHHIDSAQIYGTEAEVNGAIQAAGVKRDDVFVTTKLWKFTEPTIGLEEIKASVQRSLAELTFIPDLLLVHNPYIPEKGKIGEFWKHLETLVEDGTLKGCSLGVSNFRPVDIEEVFKTAKIKPVVNQIEYHPYVLEHLEPLLKVHAKYSIVTQSYATLSPVARHPTGGPIKPILTRLAATLSKESGETVDEAGVLILWAVSKGVVVITSSGDEGRIKKMAATERVRDLSSEEIEEIDQAGRKIHFRVWDEHMTNEFPDPDLPTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASR4</accession>
    <name>A0A1Y2ASR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_545481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASR4"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASR4"/>
    <dbReference type="InParanoid" id="A0A1Y2ASR4"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000120">
        <property type="entry name" value="MAP kinase phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF530">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0271350-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="575"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="649"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="728"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="794"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="888" mass="95352" checksum="22C1CF91BA359C3D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT21</accession>
    <name>A0A1Y2AT21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_544091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT21"/>
    <dbReference type="STRING" id="71784.A0A1Y2AT21"/>
    <dbReference type="InParanoid" id="A0A1Y2AT21"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000426">
        <property type="entry name" value="Aldehyde reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="373" mass="41839" checksum="242A92632403CB3B" modified="2017-08-30" version="1">MRRTSNVRYRTTTMYSLYESTITDRSAQPHTHFEMARAIPKDSLILVTGVNGYIGSHVADQLLQAGYRVRGTTRDLEKVKALKQYWETEHGPGRLEVVVVKDMAHEGAFDEAVKGVAGIAHTASNMTFSPDPNKVIPEVLAGINNILQSAASEPSIKRFVYTSSSTAAVHPKPNEEFTITTDSWNEEDVEKAWAPAPYEAERAVAVYSASKVEGEKALWKFVKDYKPHFVCNAVLPNSNFGKILVKGQPASSASFIQAIYYGNITEGVRSFTPQWFVDVQDTGRLHVAALIDQTVENERIFAFSEPFNWNDVLRHLRALRPDHKFVDDFCDDNIRDRSKVQNERGAELLKTFGRPGWTSLKESLKNLLDSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU00</accession>
    <name>A0A1Y2AU00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_589854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU00"/>
    <dbReference type="STRING" id="71784.A0A1Y2AU00"/>
    <dbReference type="InParanoid" id="A0A1Y2AU00"/>
    <dbReference type="OrthoDB" id="2559954at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="291" mass="32637" checksum="7CA80907CCC2F8F6" modified="2017-08-30" version="1">MEVIGANLAYRLVGDASRPLIITLHVGRGLGSHGSDFTAYKSLSDRYRVLSFDKRGHGVSSVTPPFTFQQLVDDINCIREKIVGDEKVISLGGSFGGFLAQQYVLTYPQTVSHLILLGTVPSHHHETEAHEQFKSRLHLAPMDSVSMLIKVFSAFKDDNELRVAFFAINRLYYANYDPDVGLEKNRSTSHRAEVHNELYSERETYFDYRERLRSVIAPTLILVGENDWVYTPSRSLLSSRLSPFGPAIDQSRLIAEKIPASTLLVVPNANHAVHHDQNGVVIEAICEFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUH2</accession>
    <name>A0A1Y2AUH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BCR39DRAFT_279272</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUH2"/>
    <dbReference type="FunCoup" id="A0A1Y2AUH2">
        <property type="interactions" value="649"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUH2"/>
    <dbReference type="InParanoid" id="A0A1Y2AUH2"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="21">
        <location>
            <begin position="274"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORY25857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="531" mass="60595" checksum="C2B44675E260C1A7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVF6</accession>
    <name>A0A1Y2AVF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_541117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVF6"/>
    <dbReference type="InParanoid" id="A0A1Y2AVF6"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="430" mass="47090" checksum="6B35A170DCA84575" modified="2017-08-30" version="1">MLYPHHPPSLLPLIRPLLPQSLALFGTVVLNTWPVSPKPGSSSELFGSAWCTFPTTSIPFPLPRPSPLTATIATTSTSSSLSTLSTQTQTPSLNGTFKPVSPSSLSTSPSTQSPSTSTLTPSSSLSTLPPSTSPTVPTANPDQWVMMIHLPHPTSYQLRLLTSLDNTPLSSLTPDQIESMQNLVQSSLREIKRLDPGLEILGGLNVKWLQGAERVDGVKLRNRCLTFIAPDSWGREYNLNPNHNQAQNGKERDGLRIDGGHQDDCQTIKQYRDSSAPIEYYIDRIPYTTVIRPSTSVTTDAITTTTTNTNNSATPDTTANTTNTPTTLDTDNTNDTTSINSKPIPPVAWIMTHTYGDMGALFTLPSHRRKGLAKWLVVERLQAMRQDGRQPIGWVVVKKGNLASEALWRGMGWQEGWECVWMTLSSDTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVH0</accession>
    <name>A0A1Y2AVH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_540674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVH0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVH0"/>
    <dbReference type="InParanoid" id="A0A1Y2AVH0"/>
    <dbReference type="OrthoDB" id="2565167at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="37240" checksum="F4E83926F9211955" modified="2017-08-30" version="1">MSSASALPSSAAPSSPSSQAPSSVAPSSDTPSSIPPSSTQPSSTVSSTPSSTPSSTSSSNAGASSTPSSTPTSSGASSVDPSSSASSVSSVSSTPSASGESASSASASAASASQASASSNQPTLVTSVVYVTTTNGAGQQVTLTSDVVSTSAAGASHGSNTGAIVGGVVGGVVGLALILALLFFLLRRRRRSHRDDFDDMMFDPSRAQNAAPVDLADEGNRTVEPFYTPGPAATATAATSPQMSQYPRSAATTSDGGDLSRGPSTATSAGFAGRGTAGAYAAEQFQPMPVPHPTGAADSGVGAAAGSAEAMSAKQREAYHEHQRFRVANQAGPSMALGEPMSPTLDGTGPVTVHEDAGLAEEPVYSAEIPPTYDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVQ8</accession>
    <name>A0A1Y2AVQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sin-like protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_540784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVQ8"/>
    <dbReference type="FunCoup" id="A0A1Y2AVQ8">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVQ8"/>
    <dbReference type="InParanoid" id="A0A1Y2AVQ8"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="344" mass="38376" checksum="61BDB8C9544AA5D6" modified="2017-08-30" version="1">MSAGNPDQPPPPASDIVAVPSTVDPSPGPELEVDVPSSSTLDPIPLNLDVPGPSTTFIPRQPSPPLPDLSHRPFPPNHSYLDDEEPDEVIAQLPIYLSPAIFPNLHLFQYPLHHTDFGVTEWASARGKTVSARMKEAVGRIEVEVPIKTETNVWRDERARELGYVTDVNAVNGSNGDIEGGKRGRKKDTLPKWGDKMRLKGEVVPEATGYYSGIIRDGALHLHPISTVSQFRTSMTYLDEFHSHENPKSQGGDDDDKRRKALPKPLVQKIRDEEKDGSGSLRELREKMVGTAQREEDDIWVPYSWKAGDDEDVLDRLERLIVPDEKRDRLKCATSGLDYLDRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVR5</accession>
    <name>A0A1Y2AVR5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative eukaryotic translation initiation factor 2 alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_541312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVR5"/>
    <dbReference type="FunCoup" id="A0A1Y2AVR5">
        <property type="interactions" value="637"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVR5"/>
    <dbReference type="InParanoid" id="A0A1Y2AVR5"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="300" mass="33521" checksum="96BFB9B2550F4E9A" modified="2017-08-30" version="1">MPRFYENKYPEVDSLVMVQVQSIQDMGAYVTLLEYDNIEGMILLSELSRRRIRSVQKLIRVGRNEVVVVMRVDPDKGYIDLSKRRVSAEEVVKCEEQFEKGKSVDSILTQVAKKRGVPVEELYEKVAFPLHRQFGHAYEAFKLSISEPDNVFSSLSIDADTLADLRAVIARRLTPKPVKVRADIEVKCFAYAGIEAIRNALQAGEAVSTEDVQIKVKLVAPPLYVLSTTSTDKVAAVELMEKAVEAIGEKITQEKGDMTVKMKPKVVSETDDAELKALMDQFAQANTDVAGDDDSDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX55</accession>
    <name>A0A1Y2AX55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_539118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX55"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX55"/>
    <dbReference type="InParanoid" id="A0A1Y2AX55"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY27076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="808" mass="89603" checksum="E7BF2E913411E6B9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXM5</accession>
    <name>A0A1Y2AXM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_538400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXM5"/>
    <dbReference type="InParanoid" id="A0A1Y2AXM5"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="732"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="732"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="818" mass="89263" checksum="7AA09FB39F9D8DBE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXV8</accession>
    <name>A0A1Y2AXV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BCR39DRAFT_538354</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXV8"/>
    <dbReference type="FunCoup" id="A0A1Y2AXV8">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXV8"/>
    <dbReference type="InParanoid" id="A0A1Y2AXV8"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORY27326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="609" mass="66138" checksum="CA52DD681AF1DA16" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYF1</accession>
    <name>A0A1Y2AYF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_538218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYF1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYF1"/>
    <dbReference type="InParanoid" id="A0A1Y2AYF1"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="431"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="746"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="902"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY27484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="945" mass="104990" checksum="00F3B87E7007602F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYT2</accession>
    <name>A0A1Y2AYT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_537598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYT2"/>
    <dbReference type="InParanoid" id="A0A1Y2AYT2"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22092" checksum="CCAC653AF4DC092C" modified="2017-08-30" version="1">MTTEQVRFNDHRFRPHNSPPDFHPSVSSDGHQVAFRTVGGTDWWRLPEESRDTGVMFGFNRVMIPQGIEVGCEVDLDVTIQYDQATIMLRAGDTWVKAGLEYDNDKLYAGCVIANYYSDWSIQPAEHTISKRFTIALKDRMLKVYLGDEMIREVVAFGDGKSEEVWVGVMGCSPKGTGTEVRFKDFTIKEGVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ63</accession>
    <name>A0A1Y2AZ63_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_588952</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ63"/>
    <dbReference type="FunCoup" id="A0A1Y2AZ63">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ63"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ63"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="411"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="695"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="900"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY27869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1024" mass="111122" checksum="CD5AD76E7A3B6522" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZN6</accession>
    <name>A0A1Y2AZN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tet-like 2OG-Fe(II) oxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_589011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZN6"/>
    <dbReference type="InParanoid" id="A0A1Y2AZN6"/>
    <dbReference type="OrthoDB" id="3132747at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046798">
        <property type="entry name" value="2OG-FeII_Oxy_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20515">
        <property type="entry name" value="2OG-FeII_Oxy_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tet-like 2OG-Fe(II) oxygenase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="402" mass="45196" checksum="CB6C70F0A0B30376" modified="2017-08-30" version="1">MDDKIRSKQNQLMSKRLLHLEDSMSKSQKRRCRRRRSMAKASAYIELPKLTAQLADTSQSLVVLSHLAEVDLPKFRVLKVCHSQSRLEKIRSLEALNGDRPMGCITLDEAKQHLDVTIVKDGFSVLWDEEQGTCVGVISFRNLNKLDEVERDKTIRLFEVLDKVCATTNNLAKTNGAKCLGRMHAWGWSPSFAPSKAVKRYKPAPGSDKTQKWDELAGGEIEEVAAHLETRFRKTYRCGFEAVKTTAEEHHVVPFSASNPNCSKLQAGPNSLTVTKNGFSNRQHQDHDLSPYTFGMFFAGNATDGRFNGDVHGGNGKVIGGEFFWGGYGIVVGTAADDEFVELMWRGPQDFHGTLACRLGDGQSWKNVSRWGCSMQMTKAYRQRSLKYMDHKGQFPEELIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZP5</accession>
    <name>A0A1Y2AZP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_588937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZP5"/>
    <dbReference type="InParanoid" id="A0A1Y2AZP5"/>
    <dbReference type="OrthoDB" id="2595387at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="199" mass="22500" checksum="F6BBCFDE9C87AF57" modified="2017-08-30" version="1">MDEITHTTLKVVEEDASMRTVRDLSDPEVFISQVFERQCRYVGIYQPGDFHRPEYRLVLPCYDTPRPGRGYRGAREEVFYATSDRKNVDRVISSLLELAGDGPLVAARHIVNPSNKDEGLRLIWASIQEDASVKEEMNDWPRRDAMIRQGKTVQPVQGSEWDMDNAGLENLNIPGSRMESGSHVGASTAKRSSSMEIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B117</accession>
    <name>A0A1Y2B117_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_559530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B117"/>
    <dbReference type="STRING" id="71784.A0A1Y2B117"/>
    <dbReference type="InParanoid" id="A0A1Y2B117"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="307" mass="33393" checksum="E273B7BAAFC8F667" modified="2017-08-30" version="1">MHDIAGPYNSYAGYAQPVDHTSHSPSHYYHPYSRGGHTSPRFLQQAQPISPPLSASPPGSLRLPSGVLTSPPTSISPNMVSPVSALDSGFSSDVSPMGHWAYHQPIGTPLTSVTALSGLSPQMSPGLAMVQGYFPQQTSPKGAVTRTRVTRPRAAKTQTSSRTIKKERRSSDDGLSDDEGQNNSGGGGLGFTPAIRESDGLIIFDRPEAIKKARIESEQRRRDELRKGFERVKDVLPKSNQRASKSNILDRAVAHIEQIHASNNYLLAQLEQKEKELASLRAAHQDLASIMARRSDSDSNKSSPQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B163</accession>
    <name>A0A1Y2B163_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_496423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B163"/>
    <dbReference type="InParanoid" id="A0A1Y2B163"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="134"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="630" mass="70970" checksum="61E5985FB5C370E8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1A5</accession>
    <name>A0A1Y2B1A5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eukaryotic porin/Tom40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_534316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1A5"/>
    <dbReference type="FunCoup" id="A0A1Y2B1A5">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1A5"/>
    <dbReference type="InParanoid" id="A0A1Y2B1A5"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000013">
        <property type="entry name" value="Voltage-dependent anion channel protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="292" mass="30702" checksum="BD93E71834CC79A6" modified="2017-08-30" version="1">MSQPVPPSWRDFGKSSSELLLKDYPISGIGLEVKTLTPSNVTFKVAGTRDGDSGAIAGDIEGKYVDFKNGLTFTQAWTTSNLLRTQLELENQIAKGLKLDLATTLNPAKSQKAAILSAVYKQPSLHTRATIDVFKGPTFTADTVIGRDGFLVGAEASYDVTSGAITRYNGAVGFSAPEYAITLHGLGNLSTFAASYYHKVSKDVEAGAKAVYDTKSTTGGVSLEVGAKTYLDNAAFVKAKINNAGVLCLGYTQALRPGVVASFGLALDSTKLNDPAAGQAAHKVGAKFTFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2A2</accession>
    <name>A0A1Y2B2A2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_533329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2A2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2A2"/>
    <dbReference type="InParanoid" id="A0A1Y2B2A2"/>
    <dbReference type="OrthoDB" id="2594499at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="767" mass="85118" checksum="AD01872954590CD6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2M2</accession>
    <name>A0A1Y2B2M2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_533440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2M2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2M2"/>
    <dbReference type="InParanoid" id="A0A1Y2B2M2"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="200" mass="21988" checksum="0C4FCD22060621F5" modified="2017-08-30" version="1">MSATTRNIKCVVVGDGAVGKTCLLISYTTNAFPGEYVPTVFDNYSSQVNVDGMTVSLGLWDTAGQEDYDRLRPLSYPQTDVFLLCFSVVSPPSFENVRTKWWPEILHHSPGTPIILVGTKLDLRDDPLTIDKLRERRSAPIQYAQGSAMGNDIKAAKYLECSALTQKGLKTVFDEAIRTVLNPNRRAGKAKKQGGGCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2T3</accession>
    <name>A0A1Y2B2T3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_532733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2T3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2T3"/>
    <dbReference type="InParanoid" id="A0A1Y2B2T3"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="6">
        <location>
            <begin position="62"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="161" mass="17489" checksum="A4AAAB48C50C082F" modified="2017-08-30" version="1">MSQSSTPTQQSTSTPLSPNRSIDGTWSSSPLSSPDKDSVGSGDGGIRVTSILGLHQVPDDRPVFTCQSCSEPVALQDELVSQAFTGRHGKAYLMNSTINTRLGKREERKLLTGTHTVADLACASCNASLGWMYIRAPNGEQRYKEGRYILEAANIVKENNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2W2</accession>
    <name>A0A1Y2B2W2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_533026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2W2"/>
    <dbReference type="FunCoup" id="A0A1Y2B2W2">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2W2"/>
    <dbReference type="InParanoid" id="A0A1Y2B2W2"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000009">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="110"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="315"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="623" mass="68495" checksum="317D637F59CC9150" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3F4</accession>
    <name>A0A1Y2B3F4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_532500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3F4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3F4"/>
    <dbReference type="InParanoid" id="A0A1Y2B3F4"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11082" checksum="8E5D3985A405313F" modified="2017-08-30" version="1">MALCIPLIFGFPTKIHQDAPEPGRACPHCHNASVVGASSRTWFEFFWIPLIPFPKHRIWKCGICQWEMRMGDGPDPQAPGAFAQQGFGGVRPPPPQGYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B458</accession>
    <name>A0A1Y2B458_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_531877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B458"/>
    <dbReference type="FunCoup" id="A0A1Y2B458">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B458"/>
    <dbReference type="InParanoid" id="A0A1Y2B458"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8 9" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="226"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="360"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY29514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="486" mass="52370" checksum="4F4BEB53B7D250B5" modified="2017-08-30" version="1">MSTSWTELLNELNRDVSREQPKDVVQWGSDWFQARLKRDRMSTSGTSNVPLKRGPPGSLSAFSALPSHDLSQAPHTPSPFSETGPSDNPFGGPRRATVPTGSNNVNTGAPIFSAPFGAAPAREASPFGDVPSFAANPFGQAQSAPSAEEQQDEPPVPSYALGRRTSVSAESLVPTNQRGPALSNGLETTMEEDETTPNQGSTAIPVFPKTEEQLARIKSAIKPNFLFRNLDEEQEADVLAAMNEVTIPAGEMIIEQGAAGDYFYVVESGKLDVFVKRDGQVLDPEKGDKPALGKKVATCTEGNSFGELALMHNAPRAASIISLTPCNLWALDRVSFRTILLDHTSRKRRLYESFLAEVPILASLQPQERAKIADVLESRTFTEGEAVITEGDAGEEFFLIESGSAVAIKKDASGQEIVVKQLVKGDYFGELALLNHQTRAATVRAEGAEKLRVAALGEQAFTRLLGPVKDIMARNVGERYGFAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4Y3</accession>
    <name>A0A1Y2B4Y3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_495109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4Y3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4Y3"/>
    <dbReference type="InParanoid" id="A0A1Y2B4Y3"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="332" mass="37286" checksum="826067FE4A36F9FE" modified="2017-08-30" version="1">MPIKVDEAPNGHAPSKLPTVQRLPSTATVDEVCEELKLAGGVIIERFLENEVLDQMEAELRPYLEADWTKNKEIVSEDSFLVSRTQRCAGFFGKSKTSALAFLTNKLWRGVSDKFMTDRYSYWEGPVRKTATCAPAVNNSIVFSVRPGAPNQPLHRDDIVQHYINEAIDVYPDLDSEHHREGCIGLFIAGRPSTKANGATRFIPGSHLWAEDVPPLESQAFYAEMARGDACIILGSAYHGGSANTTEDEERLLFSSFMVRGYFRQEENVYLSTPISTVSKFPKDVQKVFGYQRYFPHGNYGPDGRDPIESVEKWEEYWSCGKPADATVQFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4Z9</accession>
    <name>A0A1Y2B4Z9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Secretory pathway protein Sec39-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_505522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4Z9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4Z9"/>
    <dbReference type="InParanoid" id="A0A1Y2B4Z9"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="250"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="928"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="951"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1087" mass="119331" checksum="8E5EDFEB3A4649E1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B596</accession>
    <name>A0A1Y2B596_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_574689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B596"/>
    <dbReference type="STRING" id="71784.A0A1Y2B596"/>
    <dbReference type="InParanoid" id="A0A1Y2B596"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF16">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="678" mass="73308" checksum="318071B84ED50D33" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5B5</accession>
    <name>A0A1Y2B5B5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsular associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_467284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5B5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5B5"/>
    <dbReference type="InParanoid" id="A0A1Y2B5B5"/>
    <dbReference type="OrthoDB" id="3235770at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF2">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="606" mass="68144" checksum="698D1844656CF4ED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5R1</accession>
    <name>A0A1Y2B5R1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_494779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5R1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5R1"/>
    <dbReference type="InParanoid" id="A0A1Y2B5R1"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY30179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="320" mass="35542" checksum="1EC9F7E8B633A4D9" modified="2017-08-30" version="1">MMRQVSVDEPLLRVGNTLGEACVWDARTQRLYFVDIDQRKIFTYEPSSGIYGYQVFERKISSIAVMEDGTGLVAAIEAGFAYVDFSSLPFPPTGKPSSMRLIIDTNISFTDREQRFNEATVDPAGRFLGGTMGFNIGDSDSKLYALTVMPDGRHQTTLMLKGIGCSNGMAWSLDHQTMYFTDSWVKEIYAFDYDLKRGTMSNRRSFHTFSDPYGYPDGMCMDTEGGIWSACWSAGKVIRIAPQGKVDVVIDFPTAWHMTCCIFGAGPDLKDLYVTSANSAYTGSDLDSPDRHDGGSLFVVRGLGYRGLERNKFRGASARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B674</accession>
    <name>A0A1Y2B674_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_529268</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B674"/>
    <dbReference type="FunCoup" id="A0A1Y2B674">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B674"/>
    <dbReference type="InParanoid" id="A0A1Y2B674"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011830354" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="17"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY30341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="487" mass="53315" checksum="1A1349D2F3EF870A" modified="2017-08-30" version="1">MLVWQLVLPLLPFAFALGPPPSFVNTAIARTVELGGATTQITTQYNVKANTDGPGEYWLALGGEKEDEPAWWEVQVGGKVVSDVQVISSSETNGAPTVVVPVGNLKKGDTFTLSLTCLLAHKSRPKPAAIEQRDPQYLVWETNSTYVDSWYSSDVERIKIRSPSPQIAGYGSVPSTFTRDSEITKSSSTLTLGPFHSLPPTLGEGAAEQPAFWVHYEAKEPVVELKKLKRSAEVSHWGANLNIQDEMSLVNSGPKLKGHFSRLAHQQSKFHATTPAQILTDITLRVPPTAHSAYYYDTIGNVSTSHFRPGSPPAIKTKASRVSARTVDGVLELRPRYPLLGGWNYSFVVGYDMPLGHVLKVENGTSGRKILGVPFLTAWKDLLVDDAELTIILPEGAIDVEVYTPFPVDSITHSIHKTYLDSTGRHAITLTKTMCTENHAQNVYVTYTYPTSATLQKPLTVSAVVGGLFILMMGLRRIDYSIDKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B687</accession>
    <name>A0A1Y2B687_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_155188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B687"/>
    <dbReference type="STRING" id="71784.A0A1Y2B687"/>
    <dbReference type="InParanoid" id="A0A1Y2B687"/>
    <dbReference type="OrthoDB" id="2594106at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="313"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY30244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="59894" checksum="232756884F1A9F16" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B745</accession>
    <name>A0A1Y2B745_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_587910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B745"/>
    <dbReference type="STRING" id="71784.A0A1Y2B745"/>
    <dbReference type="InParanoid" id="A0A1Y2B745"/>
    <dbReference type="OrthoDB" id="3192156at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="292" mass="32100" checksum="BAFF338B352E486E" modified="2017-08-30" version="1">MHPLAASTISSTRSFLPYLTTPVHPWIPFGLIDVFGFYRLPGVINWIASGVFDPNHPKGQRSTLLQELFGLCVVLFGGETFLCMCTGQTPSWMLDPKLALFFCTSHTLLTRTPLRKVLPSRPKLAVELPLAIPDAIGRVFLLTRFSLIPLLHPSATTLSLPATPTTLILVPVILAVPSASIIFTATNWFSPKPHLSTPLELRPGGWAYVDTWAPLAVPLLFLSLVAPVKGWPWGFGTRLDEQSAEAVCVLFLSAVFAARAIYNFGYSRDQWVEAFTFGFGSKRKGGKKFKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7D4</accession>
    <name>A0A1Y2B7D4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_158930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7D4"/>
    <dbReference type="InParanoid" id="A0A1Y2B7D4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="353" mass="38880" checksum="B4D89226F9B176AE" modified="2017-08-30" version="1">MRSPSPVVSDPQPVPTRIALSPDSSPELESTTRSTWVTRTPPRIAQQPVEYDELGTDSDSKSDDQEAVDLGSTSSGLLDSIESFRPANDNPTESFSKRKQGASPEATEVDWTRTPFARFIRRDESLRTKMQIVSPESIERDWTGNAFARFIREAKDATKSPNATHKLSQYSENISRDSGQASTPVQPARLQIASKSDVPTTPIRSKSAKLPCTPPMTSSTEVSFILDPTAQHSIPTTPTQHSTPSRSLMTLKAPMTPDSTHQSILTTIHTLVDLIASPSPARLPILTDEYNHDVPQRICKGEKDLNEKYEKYGTTDMADLAEQVARKVRTGNGADMNDAKYMVLALSKLLNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B895</accession>
    <name>A0A1Y2B895_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_466187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B895"/>
    <dbReference type="STRING" id="71784.A0A1Y2B895"/>
    <dbReference type="InParanoid" id="A0A1Y2B895"/>
    <dbReference type="OrthoDB" id="3366231at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51084" checksum="864CB0156FFA7893" modified="2017-08-30" version="1">MSAETTTTNIRHSQRQRVPRVIYSPPLPSLPRHHHHHHHHHHHHHHHHHQPPHHSVNPEEGVEVASRDEPHARRSQRTRRPREVYAPEEPQPSRRSLGQLQRHSLARQDINQPQSPPVESFPESQQPVNPRQRWDNLQATRLACCLVLPLSVGRHMLGSLNVVCESCLALHWEGEKGDSAPAESMGDFLTCCMYGAIDLQPLPPPPPFLQHLFTHHGPGNEEARHFRQSIRSYNNALAFTSLGVKDDHSLSRSRGPPIFKIQGQLCHFIGSLLPVTASAPQFLQVYISDNTLAAQNERRLARAGPFNLRPSLLHQLSALMESHNPYAQIFLNARTRLSMLSPDETLSVHLSTIQPHEKDPRCYNRPRGQEVGMIIGGQNGNDEGNQGHRDLVVEQRDGRLARVSETHSTYLPLRFVLLLPYGSNGWVQHLPRGQLHRWAQAVDTSRGGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8U6</accession>
    <name>A0A1Y2B8U6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_558300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8U6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8U6"/>
    <dbReference type="InParanoid" id="A0A1Y2B8U6"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="513" mass="55981" checksum="8CD2BA474AE40A7A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B932</accession>
    <name>A0A1Y2B932_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_571286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B932"/>
    <dbReference type="FunCoup" id="A0A1Y2B932">
        <property type="interactions" value="647"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B932"/>
    <dbReference type="InParanoid" id="A0A1Y2B932"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="277"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="509" mass="57892" checksum="ABDE3BCA5D0D178F" modified="2017-08-30" version="1">MSLNTRKQEKDYTEEVQTLVPEAEAVAKDGKLQEAIDKISSLEKQTRNAADMTSTSTLLTTLVRLCYEAQDLDALNTQLTLMSKKHGQLKEAVTRMVDEAMTWLPELKKQKVEGKFKVGKDRWLELVQTLRDITEGKIYLELARARLTVLLASYHESLAESAPAEASTSTATAIPAKTSKDEPKPEPITKRDHIDTAADLMSEIQVETYSSMDKREKTDFILEQMRLESLRGNWARVRVGSRKINRVYLKEADSADLKLRYYDLMVQLALQEDAYLEACSAYQEVWDTEEVKKDEARELHVLENIMIYVVLAPYNNEQSDMLHKLYADQALQKAPLYYDLVKCFVTKELMRWPGIETLYGPTLRQTPVFSPNSKLGIKTGSIAEGKRPEELSNPGDARWEDLHKRNIRVIAAYYSRITMTRLTELLDLSALTTERTLCKLVTDKTIYARIDRPAGIVSFKQKKGINEVLNAWSGDVAKMLELVEKTSHLVSKEYAMHEASQGKKIGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9D6</accession>
    <name>A0A1Y2B9D6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_558163</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9D6"/>
    <dbReference type="FunCoup" id="A0A1Y2B9D6">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9D6"/>
    <dbReference type="InParanoid" id="A0A1Y2B9D6"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="333" mass="35838" checksum="5FD103F9E40B83DC" modified="2017-08-30" version="1">MSTSSLPSSGSFPVDTSALFGKKSKSKDEVISFRYAFKPASITSATPAVLTTESGSRRLIYEMQNGSRQVFDVREETCKPRECVLIYNEVDQTFSLRALPTTLHLTLNRSLSTATRPAGPPSIASSSSSGSVPLSKRKHTDISESSNTTAKIEAESETAHRPKKARPSQVRPAAPTPQKVSRKTLPATSTTTSSSAIKAKESKSVGGKKGQTKQPVGKYKSAEIIEDSDEEAGDLTIMDKDKDKDKEEIGVGDEDVGVGVGGDGDEVEEEEDEDDFARLLGDEMAADEAAADDDSDDEDEEDDEEDMGLGGARYISRKQTAPQEDLNGDSEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9T9</accession>
    <name>A0A1Y2B9T9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_86195</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9T9"/>
    <dbReference type="FunCoup" id="A0A1Y2B9T9">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9T9"/>
    <dbReference type="InParanoid" id="A0A1Y2B9T9"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000062">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-36 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="19">
        <location>
            <begin position="112"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="168"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="18">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="712"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="815"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY31608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="843" mass="93948" checksum="E020B25B37288D80" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9V0</accession>
    <name>A0A1Y2B9V0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inhibitor of apoptosis-promoting Bax1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_525839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
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        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="94"/>
        </location>
    </feature>
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            <end position="124"/>
        </location>
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            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="274" mass="30163" checksum="44ACD93331945B68" modified="2017-08-30" version="1">MASPPKYTDSPTKGYGTTSTDAAAVQPLLAAQAGSSRNAWMNQPAEDDIPEDFKIGVAVIDCDASIRLAFIRKVYAILFVQLLVTSLVALGLSTGPAVEFTGQHPWIMWIPILGSFTSLAGVYWKRHQHPANLILLGLFTIFEAMMVGLVTSYYDSRIVLQALFITLGVFTGLTLFTFQTKFDFSSFGPFLFAGIMGLLTASLVQIFLPFNQNVDFAIAAFSVLLFSGFVLYDTQQIMKRLSVDEAILGALTLYLDFLNLFLSILRILNNAKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9W3</accession>
    <name>A0A1Y2B9W3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_504725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9W3"/>
    <dbReference type="InParanoid" id="A0A1Y2B9W3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="302" mass="33799" checksum="826279FDBC7EE773" modified="2017-08-30" version="1">MAPTIYVQTRFDRARREYTDKYPSSQLASTTKEERARLAIKWYAEFGGQYPVLATETSSTGSSSPPGASSDTSSKAVQQYTSHQSTKNPSQLSSPADHSEPSTPSHLQPTSSSNWRPSLWSNPFVRYAVTVGKSLLETDPVAQQVSLPDARSKDYLWTIQKDWTDADWDVFWRRQPSTDMQKKFTPADWDAYWMDQPSNVPPALANFLQGSPGRFGTLWNSMHNPYVNEMKTNSALESSEEFTPCWPDPLGVWKAKDGSDIAASCSETPSSVGWPRFVPNLEGSNQGIGYLDLTPYDDQDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9X6</accession>
    <name>A0A1Y2B9X6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_493693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9X6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9X6"/>
    <dbReference type="InParanoid" id="A0A1Y2B9X6"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="385" mass="43472" checksum="AD9DEF75C72C70C5" modified="2017-08-30" version="1">MSDSEDDFMSDKFLVDVAPSSKSYSDKRNAQTLKSLRASQAKTQVPLKQLEAERRREGLNRSLFDREAESSTSGGASKAMGMMMKMGWKVGDTLGKQEASRRSASPESSSKRARIDEDDDVPRGGLGRARAEPIRVSMWAGRKGLTARDPSPPPLPSLSGRNVDALDPSKLERLGRETEDFRARQRREFAEKEIERKEYKAREILVGFDRDKGIKFHPLHVLPTDPLGTLPQPLLKLIYPSQIVSPSRSPSPSEAIQGQPVQRNLTAAEKLREEMRRDMLTQLGGEEDSDNDEDDDLAFGKISRQVDEKPERKKQSLEDWDGIDWAEMVSGAKKVLSMEPKTHLTFLVDQLRHEYLFCFWCAHRYKSWEELEGPGGCPGVDEDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA03</accession>
    <name>A0A1Y2BA03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_558313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA03"/>
    <dbReference type="STRING" id="71784.A0A1Y2BA03"/>
    <dbReference type="InParanoid" id="A0A1Y2BA03"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="111"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="356" mass="39181" checksum="5D8E8467DEDA6FC6" modified="2017-08-30" version="1">MGILSKAHRIPAALLGAYIGLLVLLAMPPVQRMLVYMHVFHWPLFAEFDKPQSYGLAPFKTRDMELTTPDGETLGVWHVLPSSVYHDAAEEFPPTSSFSDEVFDAAFRARPTIIYLHGNTASRAVSRRVRSYSAFSTYLDCNVVVIDYRGFADSTGKPTEGGLLIDARTAFDYVYERNGNRADQIVLIGQSLGTGVASGLSGLLADDGITPRALVLIAGFTSIRDILLTYKLFNVIPVLSPLRLIPSLHNFASKLLLHPFDSPAALSRTSLPVLLIHAADDPVIPNTHSTRIFELLRTSASPAREIQYDGWGVVRSYERQGKGEVVWWDGLTGGHDDVGWAEGTMDLIKRVAQIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAE7</accession>
    <name>A0A1Y2BAE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_466231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAE7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAE7"/>
    <dbReference type="InParanoid" id="A0A1Y2BAE7"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="439" mass="48258" checksum="902F3629C904E2C0" modified="2017-08-30" version="1">MYLNAYLGRRMSLVCTAVVSLVGIVIEMTSATGSSARYGQFIAGKIFNSIGMGLTANIVPIYLSETSVSAARGFVINMYQTIQIVGIVVASAVVYAVSKRTDRSAFLIPMGVQAVAPGLMLFSSPFIPESPRWLVWKGRNEEAVQAANALFSTPSNTFNAEEYCYKLKVAYEEEKRASAGTGWLDLMRQPDLRRVLIATGVQSLQHAQGSSYMTSYIVSFLIGIGVKDYFPIVMALNCVYFAAVCTGYFLPDMFGRRSLLLGPSALCGICLICVAALVTAYPVPPPAVQKASIGLIFIWEFAFGLQGPAVWIVTTESAPARNREKVLGVATFFGFGVALMITFVSPYIQNKGYGNLGSKIGFIWGSFSIIMVFYTFFFVPEYKGFSLEQIDYLFETKVPTRKFATFQFTDEILATVTDDIKDTKEDEAKMEVEEVKELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAF6</accession>
    <name>A0A1Y2BAF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_525600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAF6"/>
    <dbReference type="FunCoup" id="A0A1Y2BAF6">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAF6"/>
    <dbReference type="InParanoid" id="A0A1Y2BAF6"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY31829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="673" mass="76043" checksum="8F63A27C6DCF7278" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB41</accession>
    <name>A0A1Y2BB41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_524825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB41"/>
    <dbReference type="FunCoup" id="A0A1Y2BB41">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB41"/>
    <dbReference type="InParanoid" id="A0A1Y2BB41"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY31964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="486" mass="52858" checksum="C83993F4F6A3A91A" modified="2017-08-30" version="1">MEPFAGSSALRDIPNEKEDAKSTLVTWDGPDDPENPQNWPRTKKVGVTALLGFTTMSATFASSIFSSASPYVAKQYGISSEVGILGLSLYLLGFTVGPIVFGPVSEVYGRKIAILPAVFIFICFSAATATAENLQTIFISRFFAGGFASSPVSVVGGAMADFWSQRERGGAIVIYSLCVVAGPSLAPLIGSAISESYLTWRWTEYVCVILTSTVLAFNLLFLPETSAPILLTGKARRLRFETKNWALHSAHEELDHSLTVFMHKNLVTPLAMLAKEPMVTLIATYNAFAYGVLYLLFAAIPIIFEEVRGWKPVPATLPNLATFVGTLIAAAINGYYSGKIFVRYLDTHGGKAPPEKRLPPMMIGAITFPVGFFIVGWTSNPSIHWFPSLIGFTLIGMSFLLIFQSGMNYLVDAYTRVAASAVSANTFLRSLFGATFPLFAKPLFNNLGVSWACTLLGCIAVLLGLTPIMFTRYGQRLREKSKFIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB93</accession>
    <name>A0A1Y2BB93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NUA/TPR/MLP1-2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_525256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB93"/>
    <dbReference type="InParanoid" id="A0A1Y2BB93"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="6">
        <location>
            <begin position="451"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1136"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1195"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="521"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="626"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="897"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="977"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="954"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1136"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1195"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1235"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1261"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1310"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1325"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1406"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1417"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1469"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1478" mass="158760" checksum="500420CD81442A87" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBB9</accession>
    <name>A0A1Y2BBB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_79797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBB9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBB9"/>
    <dbReference type="InParanoid" id="A0A1Y2BBB9"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="140" mass="16409" checksum="9334007519CDDDAE" modified="2017-08-30" version="1">MQELPTGLPPPPLPDGSAAPPRSQERQANLIRFQSELEFVQCLANPLYLQELFVQKYFAQKEFLNYLKYLEYWREPEYVQFITYPTCLVFLTLLQSESFRARLADPGFVTELCRIGQRHHETWRVEKPPDALKTDDGKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBH7</accession>
    <name>A0A1Y2BBH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBH7"/>
    <dbReference type="InParanoid" id="A0A1Y2BBH7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="214" mass="24260" checksum="5835ADEA133C113F" modified="2017-08-30" version="1">MSSTPRRLASLLSRLPSNGLHAIVRPHNAPSDAFYIITRSRLTFKPSPIALSPKSPSTQSSSSSSTQRVKKAVKSQDQDQEHVDVVEESSEAGPAWPEIGRLKANGKIWALPFYNGTYSAPQRKTRSPSPQIPRSLMRIGWVQVDPSTLPEAVQQNISNWKQTLQEQNEIRDQVVLQVQEKTRLARQETEDKWARFKEFKINKRQAEKTVTVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBQ4</accession>
    <name>A0A1Y2BBQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_60290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBQ4"/>
    <dbReference type="InParanoid" id="A0A1Y2BBQ4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="148" mass="16829" checksum="DED8E6C745F25915" modified="2017-08-30" version="1">MKRDNKKEIRYCSKFTPPCQAVTERRMSRMYLTKASHLRRQFLGVVTPELMIPDQPDPKQIPPISFPSFERGTDTFPIKRKGRYKCSPIYPRRSLTAIRRPQGPCVTITLGTALVMAIQVIYNATHPLGGLGRSLISRTSPIHLPYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBS6</accession>
    <name>A0A1Y2BBS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_524918</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SQRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBS6"/>
    <dbReference type="FunCoup" id="A0A1Y2BBS6">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBS6"/>
    <dbReference type="InParanoid" id="A0A1Y2BBS6"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY31980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="446" mass="48201" checksum="10674244C3372879" modified="2017-08-30" version="1">MSVISRAVPSISRSYATAATGAAKHKVVVIGGGAGGLAAANQIFNSLKAQNASLNPGDIAIVDANKNHDYQPGWTVVGSGLAKKENFRRSLDSLIPAHIAHIPVNAAGFEPESNQVVLSDGSKVGYEYLVVAAGIQTNWNKIKGLEEALKDPNTTKVSSIYSYETADKTWDLVEGYRGGGQAIFTQPFGVIKCAGAPQKIAYMSDSYWKQQSRPISSSFITGMPTMFSVPHYSKALDAIRESKGIAGEFSTNLVEVRPADKVAVFEILAGDKKGEKIEKEYGLLHAVPPMGPLDWIKKSPLADAAGWVDVDSATLQHKKYENVFSLGDSSSLPTSKTAAAITAQTPVLTHNLTTHLLTSSLAASPATYDGYTSCPLFTGRGELLLAEFKYGLERKETFGKWIDQSKPNRLFYHLTKDVFPRAYFGQMLKGNWYGPKGVFPPQFVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBU9</accession>
    <name>A0A1Y2BBU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_568999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBU9"/>
    <dbReference type="InParanoid" id="A0A1Y2BBU9"/>
    <dbReference type="OrthoDB" id="2569915at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="107" mass="11146" checksum="83E73C9EAF76CC6E" modified="2017-08-30" version="1">MPSGIGPGRPVHPFAVTVEEPIPNAIVPDGYGIKYHAYHTITEGVFLPTGTSLPGGAVLPMSSIADFPMVLPQGTKMPGGVMVPITMQKKDKLISAGSPPEPICVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCL0</accession>
    <name>A0A1Y2BCL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_478691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCL0"/>
    <dbReference type="InParanoid" id="A0A1Y2BCL0"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="273" mass="31151" checksum="72E8E75D3DD3601D" modified="2017-08-30" version="1">MRRPSFQDPLAPIWSDDKTVTAKDDDEDEYRGRPTLPKRTSLSNDGAIPNLINADSIQAVSFHSHHHLPSPRDEIPSDPILYLPPLLSPLPASVPRRPQDPSTKDWATFETRLPDIDPASLALHQALHHFRPLNSGYAQEDYDKAFNWDELTLPKEIAREWYCVVFRSRRNPESSSLSLYKADREAHEEAVRNGGLVMYWYGVPDETGLNLATCIWQSRRHAVNAISGPKHIQAMKQAKDAYERYDLERWVLSKERGQSTVSLSKWQGGDVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCQ4</accession>
    <name>A0A1Y2BCQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">acylphosphatase</fullName>
            <ecNumber evidence="2 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_523612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2 5"/>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCQ4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCQ4"/>
    <dbReference type="InParanoid" id="A0A1Y2BCQ4"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF3">
        <property type="entry name" value="ACYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY32257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="102" mass="11339" checksum="C598FF933B4A187C" modified="2017-08-30" version="1">MVDLIQFKVTGSVQGVSFRYATQKEAQKLGLKGWCRNHPDSSVEGAAVGPSDKIQQFHQFLHRGPSAAEVERVELITEKRNISEQEADKALGGRLSGFEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCT6</accession>
    <name>A0A1Y2BCT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1776-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_375726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCT6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCT6"/>
    <dbReference type="InParanoid" id="A0A1Y2BCT6"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="58059" checksum="FB284B4940BD3813" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEB8</accession>
    <name>A0A1Y2BEB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_522298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEB8"/>
    <dbReference type="InParanoid" id="A0A1Y2BEB8"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY32890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="65459" checksum="D33C464C3A6C256C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF00</accession>
    <name>A0A1Y2BF00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_519897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF00"/>
    <dbReference type="FunCoup" id="A0A1Y2BF00">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF00"/>
    <dbReference type="InParanoid" id="A0A1Y2BF00"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="150" mass="16946" checksum="7DB46F5FEDC64EBA" modified="2017-08-30" version="1">MPRILPSNIKVPTTIPVPGFRHFLTPLRKLIFDYDPYQLRHEGIRTYIKSHLVSMAKANPEVEVVVRKTKRGEAALLRGHYVNGRDKVICVNRLEHNQVAQKVDLLLNSSGAKMKHIRRIQVEAAPGGEAARGIWSAIHDQARPNGGYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF72</accession>
    <name>A0A1Y2BF72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_563974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF72"/>
    <dbReference type="FunCoup" id="A0A1Y2BF72">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF72"/>
    <dbReference type="InParanoid" id="A0A1Y2BF72"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="359" mass="40246" checksum="CEE338D9CF46162C" modified="2017-08-30" version="1">MSSPSTAPQFDPKNMIFRNLGKTGLRVPVFSYGGWLTVGAAQKGDIVKELMQTAWDSGINMFDTAEGYAAGESEREMGRVIKELGWDRRDIIVTTKIFFGTARGEKHNTRGLSRKHIIEGTNASLKRLGLDYVDVIFAHRPDRTTPMEETVRAFNWLIDQGKAFYWGTSEWSQYELQHAHEIARRLNLVGPACEQPHYSMMHRERFEIEYGPIFKQEGLGTTIWSPLDSGLLTGKYNDGIPEGSRYHTNQSVMADNIKALESPEGKAKIEKVKQLSQIAEKELGCSMTSLALAWTIKNENVSTCILGATKPEQIKENVKALDVVPKLTSEIMAKIEKILDNKPALPNAYGRHDAEGRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF90</accession>
    <name>A0A1Y2BF90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_520273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BF90">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF90"/>
    <dbReference type="InParanoid" id="A0A1Y2BF90"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="1447"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="1732"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2013" mass="222785" checksum="8B915CC5EDBEBD36" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFW9</accession>
    <name>A0A1Y2BFW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PXA domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_264808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BFW9">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFW9"/>
    <dbReference type="InParanoid" id="A0A1Y2BFW9"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="110"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="448"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1401" mass="154838" checksum="3BBFF6A21ED0DBE3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG51</accession>
    <name>A0A1Y2BG51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_520310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG51"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG51"/>
    <dbReference type="InParanoid" id="A0A1Y2BG51"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="229" mass="24114" checksum="535F7AF6FB7AEA09" modified="2017-08-30" version="1">MSSEADLQKLKVTDLKELLAKHALPQTGKKDDLIKRLLDNKISADGGEEELTDPEPLAPPETSSAPAQPPTTDAAPSDTTSTLTPEQQALKARAERFGLAFNPNPPSKPAPKPVSTPAEAEPKPAPTKAGAIDKAPLGISEETLAKRREKFGVVEKTTVASTTKAAAASNGKKEATVVAKAPAPELTPEMAEKQAIEDEKKRKRAEKFGTAKPATNGSEAEPETKKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGW8</accession>
    <name>A0A1Y2BGW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_491296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGW8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGW8"/>
    <dbReference type="InParanoid" id="A0A1Y2BGW8"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF101">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012508313" description="FAD-binding FR-type domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="309" mass="33663" checksum="AB6164BA6D85F941" modified="2017-08-30" version="1">MQTTMSKLLLGTSLVVGTGLAYTALRPTPAAGSKMFSSFRLPTSLELESVEQVSHNVKKFRFKLPEGVSAGFPMTSALLAITFPSQSWIPVIRPYTPISSPSTPGYLEFMIKRYPSGKSSEHLHSLRPGSNVLFAGPISGPKYDPKFGHVTLIAGGTGLTPCYQLMRHILKDNPLETNTNANTNNKNSTSLSSSSSSSATQIPTKITLVIGANTIGDILLKSEFDEWEKKYPDRLEIHYCISKPEGGPERPRGGLDKAFLEKTVFEPKSESSAVYLCGPPGMEESLAGKRRKGGVLEDLGFKKDRIFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH13</accession>
    <name>A0A1Y2BH13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH13"/>
    <dbReference type="InParanoid" id="A0A1Y2BH13"/>
    <dbReference type="OrthoDB" id="2596179at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="228" mass="25540" checksum="F43339D0F2870362" modified="2017-08-30" version="1">MFSRAGPSRIRAIRQTQTPTPTQTHTPIQPTVARVPFRQNSQSSRLFPDLSMRPDPRDLVVPPLKERLKPLIPFLFWWTVITSLTTNLLQLRQRSERESALSSAQITVLEGLIEKVKDGQVLEDVEIRKELEMVGLRERTELTKGLESGLEEGGDVGLLTAMLGRNSRFSAGDRKKKEQEDDERAVAEWAEIVNNESKGSIPAAASVPTTKPERIGTSRRPTSVSVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH41</accession>
    <name>A0A1Y2BH41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_234980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH41"/>
    <dbReference type="InParanoid" id="A0A1Y2BH41"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="168" mass="18028" checksum="E1B97B324C65447A" modified="2017-08-30" version="1">MPRQTLPFPFSTHHLSLSQLHLTSTSSIQKMDFSSANVPVSRDTWAPRSPPSGPAGDRDYPPPSREGYDSRAPPPVAAPETDRSYNGSTGRGGYGSGEGGYRGGRGDGGGGGGRGGYDRPIIFILPSTSSLHHCLAIYIIVYLCLAVYIYVRSPLGRRVLYSTSIRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHZ7</accession>
    <name>A0A1Y2BHZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_518922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHZ7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHZ7"/>
    <dbReference type="InParanoid" id="A0A1Y2BHZ7"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="221"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="610" mass="66488" checksum="BDB5AC016E4193F1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIB0</accession>
    <name>A0A1Y2BIB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_517462</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIB0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIB0"/>
    <dbReference type="InParanoid" id="A0A1Y2BIB0"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000002">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF134">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="12">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="386" mass="41495" checksum="79C8EEA29799214B" modified="2017-08-30" version="1">MTNSSLLPDTVPRVGINGFGRIGRAVFRQCLARSDLELVAVNHTALTIEHLMTAIRHDSTHGPCPQAVELSVAPPDHPDLLPRTEHNPVPSALIFRGRLIHLLSQRDPVKLDWQAAGAEYVLESTGKYTTRAKAELHIKHGKARKVLISAPSKDVPNVVYGVNHTTYTRADDILSNASCTTNCLAPIALVLQRAFGVETGMMTTIHASTSSQKVLDGFSTKDVRSGRSAMGNIIPATTGAAQAVVKVLPELAGKFHGISVRVPVTNVSLVDLTVRFSTPISSKEHLMAAFREAAALPVLTSSSDDTLPGDATRPRLKGVLGVSDEKLVSSDYLSSTESSIIDVDASVMLDEYTGKVVAWYDNEVGFSSRMCDLVVYMAKCEAQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIH1</accession>
    <name>A0A1Y2BIH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_513482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIH1"/>
    <dbReference type="FunCoup" id="A0A1Y2BIH1">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIH1"/>
    <dbReference type="InParanoid" id="A0A1Y2BIH1"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="161" mass="18250" checksum="AE773AA5F3E2B820" modified="2017-08-30" version="1">MPTELLSPDDFLTRLTESFSTPQTAGSIWLTHKRLSIEDGGDAEDEEAEHEVLIRCTRGDGSKFSSKIPASSLHTFHTTYGTLLKSTFAPHMRKRDKKKEKARADAVAAKRRELYVDVDIGSGGKRGKGRRQRERKIRAQHKKEEEREKVEARETKANGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIL3</accession>
    <name>A0A1Y2BIL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase family 18 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_513651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIL3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIL3"/>
    <dbReference type="InParanoid" id="A0A1Y2BIL3"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="1">
        <location>
            <begin position="265"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="495" mass="56035" checksum="54865D3B80BF164B" modified="2017-08-30" version="1">MAIEYVPLATSSAEASEVEDLQTTKRRRLGHSTLSRIALPSHLTSRPRLLYTVVGSLLLVSFFWLVRAKRSTGWTEPEPGPNPYFHTGKIWEHNDQVAARLDRCASLGLLRNISLPLPSLSADEEAELSAEGCGTAETTVVILASLWFAEAYSGTSTTGETIYAQSVISTLNALGYAYVFSSLGWYNDDMKKTTELWHKHRWNTRVVLADPEQVKVCWQHRGGQCAKDESFQEGIEVWRLLSFWYWDDSGNPLGTAFTLSPSPRNENHFLSFSIEPTCHRLPRIHPQDRPKPPQVYLLAKQMRYLDNSSAFSWTLPALDSLQDEFGVRVVGGIVDDDADAAKALSETGITNFGKLDKIEFYEQLARSSVLLGVGRPRISPSPWDALCMGVPFINPILQWDEEDPFDRSKWHAQQWHMTDIEPPYVYHVHAHDLDELRTTVGEALAHPIESWIPDYMKFDFACERTREVIEGDWLDVARGILEERKARGEGNLFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ24</accession>
    <name>A0A1Y2BJ24_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_514788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ24"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ24">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ24"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ24"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="434" mass="48458" checksum="67B84F76A75D83DC" modified="2017-08-30" version="1">MASTDPIEIDDEERDEAEINQSINEEYKIWKKNTPFLYDTVINHSLAWPSLTCQWLPDRETPKDADYTIHRMILGTHTSGQDADALLIAEVFLPKSALEMGKDVAEMYDEERQEFGSHGKSPARIQVKQTIRHQGEVNRARYMPQNPDLIATKTTMGEVFVFDRTKHETKPAANAECKPDIRLKGLNKEGYGLAWSKVKSGHILSAGDEGIIAHWDIEGYTKSSPSIQPLRKYTGHDGTVGDVDWHPSYDYMFASGGDDKQLMLWDTRSAITSKPDVQVEAHERGEINAVAFAPSSEYLILTGSNDHTIGLFDIRKLSRKLHSFEGHVDGILQLAWSPHSPVHFASASADRRVHIWNLDAIGAEQTPEDAEDGPPELLFVHGGHTAKVSDISWSPMAKWHIATTAEDNILQVWEPSRNIRAGGEADVSAMDLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ54</accession>
    <name>A0A1Y2BJ54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_585588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ54"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ54"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ54"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNNM"/>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="217"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="138"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
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            <end position="792"/>
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    </feature>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY34620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="923" mass="98689" checksum="1C00F1BAE04720AD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y2BJ82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CWC16 protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Naematelia encephala</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37905" checksum="81064DB2E27957DE" modified="2017-08-30" version="1">MQGFNRYIPPEFDPKHNSTLNSHQGKKHALGKRAKDIDKGILVVRFELPFNIWCGTCNAHLGAGVRYNAQKKKVGNYYSTPIFAFRCKCHLCSGWFEVRTDPKNAAYEVTEGATRKDEDWNPAENGGFAVHDTEAPSAAEPAADPFAGLEKTIDQQTWAKSNTSRLTELTQASARISADPYAVSVHIRRRFREEKRVMLEKQGRDDDLRERYGLAEEVQLGEEDVERGREVWEAARERRGLPIDDVSGGTGAPVIRRNGNGNGKGKAVDLAQVLRKTTTRKYDPFGEAMESVSSPGPIRTKGRIKDPIVLGGLAAGMKSAKVAEKPKPASHGLAGAGGLLAGYGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y2BJP1_9TREE</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BCR39DRAFT_592330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
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                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
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                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="53"/>
        </location>
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            <begin position="497"/>
            <end position="535"/>
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            <end position="413"/>
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    </feature>
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        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="556" mass="61003" checksum="E4DF32B4FBAB059F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJS5</accession>
    <name>A0A1Y2BJS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_515219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BJS5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJS5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="476" mass="51395" checksum="64DC4F994B1EB56C" modified="2017-08-30" version="1">MVNVNIQTTISPYTQKPLLTRPLLSDTELDGVISESLKAQKSWKKVTLDERIAVAEKWLVEFEKLTDLMAEDISLSMGRPISSCKGEVGGTLYRARHLIKIARDCLRAVPQDDASTDALKMIIVKQPIGVIGVITPWNYPLLCTVNTVIPAIISGNSVIIKPAPQTPVPAERFLSSFQAAGLPANILQVVHLTQATTLEKFCQDPRIDFVAFTGSVAGGRAVQQAASNGKGFKGVGLELGGKDPAYVRADADLKYAVENLVDGAMFNSGQSCCAVERIYVHSSLYDEFVKQFVEIAKQFKLGDPSDPTTTLGPVVSLASAERIRKQVKDAVAAGAKLVLDESAFPQAKEGTTLVGPQVLVDVDHTMEVMMEETFGPVIGIMKVESDEEALGLMNDSPYGLTASIWTSPTDPASLAVFNSMVDDLECGMVYMNRADALEPSLPWSGWKDSGRGVSLSTLGYDHLTRAKAVCMRVQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJZ5</accession>
    <name>A0A1Y2BJZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJZ5"/>
    <dbReference type="InParanoid" id="A0A1Y2BJZ5"/>
    <dbReference type="OrthoDB" id="2526154at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="957" mass="102918" checksum="7265ECE6D50991FA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKK6</accession>
    <name>A0A1Y2BKK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKK6"/>
    <dbReference type="InParanoid" id="A0A1Y2BKK6"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY35304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37700" checksum="FB178F91A8A53996" modified="2017-08-30" version="1">MLRGSSNTTSASTEVATGHIGVLRLRSDISEYRRNIETNGFAVVRGVIPPERVEDYVNRSYDWLERFGPDFKRNDKSTWDVKNLPPHAKGGMYTLGGVAHEQFMWDIRCEPAVVDTFAQLWGTDELLVSYDGMNLALPLPQEQYDHGGKPWPHVDQSPLRDNFHCIQGIVALTKSEVNDGGLLILKGSKELYGEFFKQHEHEMPEGGWPTRDLYLHTEQQLQWFYDRGCKWEKICCDAGDLLIWDSRCVHYGAVPSGDRARVAAYVCYKPASMVSADALRVKQQGFKSLRNTTHDPVIVEVPPPLPSWDGYPIAPENPPVLDTRGQKLAGLVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKU9</accession>
    <name>A0A1Y2BKU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_514123</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKU9"/>
    <dbReference type="FunCoup" id="A0A1Y2BKU9">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKU9"/>
    <dbReference type="InParanoid" id="A0A1Y2BKU9"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000965">
        <property type="entry name" value="Autophagy-like protein 18 Atg18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="282"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY34715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="437" mass="46804" checksum="AD96431FA6EBEC2F" modified="2017-08-30" version="1">MSRLTTKRHPDLLCCNFNQDFSCIAVGHKKGYTILNCDPYGKVHSKTDQGATGIVEMLFCTSLVALVGAADTQPNNSPRKLQIVNTKRQSTICELIFPTSVLAVKMNRKRLVVVLESEIYIYDISTMKLLHTIETGPNPNAVCSLSSSSEHSYLAYPSPAPSATATPSLSSTAVPSAPPAPTTGDVLLFDTLNLSALNVIQAHKTPIACLALNSDGTMLATASDKGTVVRVFSVPDAKKLWQFRRGSSNARIWSISFNLTSTLLAVSSDSSTIHIYKLANSTKKTSTTTGEQQHQLVANDNNSLDDVRSPTPSETPSSPPLPLGATTTTAPHSATSSLGRRSFRIGKSFVGGVGGYLPRSVSEMWEPQRDFAFIKLRGNHGRTVVAMSATVPQVMVVSSEGLFQAYNIDLENGGECSLMKEFALLGNEDTSGGQNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKV6</accession>
    <name>A0A1Y2BKV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_5952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKV6"/>
    <dbReference type="FunCoup" id="A0A1Y2BKV6">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKV6"/>
    <dbReference type="InParanoid" id="A0A1Y2BKV6"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="373" mass="41525" checksum="29AA88DBB0DA83EB" modified="2017-08-30" version="1">MTTDPTELHLLFILLDSNLPTGGFVSSSGLESWAKHGFLSNPTYSSSSTTQASSVTQSSSSSKSSYNSRPNQVQVIKAITDFARAEVESYSRTTGYFVRDAWKALDQISTMEMDICSKCGKSRKSSIINRKMAEEDVEKVSVEDVKIKVSVEDVVKVLVELDQYHESTLLSHVSRRSSKAQGIAMLTLHARGLSKPVRVDMDEDKDEDGNENKNEIQREREKDGRAREVVEGFKRCIRAGKSPGHLAVCWGVMCAALGLSLERTLHLHLFLHARSLLSSAVRLNLIGPYASSQLLLHPFESIISNNIPSSTDTTGILECRCVQLESVDKYASLDRDWDWDWAIDAEMGPATTWPLGEVLMARHDLQHSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL94</accession>
    <name>A0A1Y2BL94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_555659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL94"/>
    <dbReference type="FunCoup" id="A0A1Y2BL94">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL94"/>
    <dbReference type="InParanoid" id="A0A1Y2BL94"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="6">
        <location>
            <begin position="280"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="402" mass="43731" checksum="938927288D766C2F" modified="2017-08-30" version="1">MAVTKGVILVGGPSKGTRMRPLSLDCPKPLLPIAGKPMIWHPLAALAQVSGLVEIIIIGFYEDSVMSGFIKDAKREFPNITITYLREYRPLGTAGGLYHFRDSILRAPTPQHIFICNIDVACSFPLAEMMTLHSKHRGVGTILSVTVKKETATQYGCIVTDPETQQMVHYVEKPDSWISNMVNGGVYLFDKTLFDEIKVAMDDKTARAAEDPLVKPDEILRLEQDVIVPLAAAKKMYVYETKSFWRQMKTAASAVTASSLYLNNFAKTSPELLAKPSASIISPTFIDPTASIDPTAKIGPNVAIGPHVRIGKGARVKDAIIMEGSVLEQHSCVLNSIVGTDCHIGPWARVDGAPEPEAEVKGQISVTVLATEVTLAPETLVRSCIVLPNKSLDRNSANQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLB6</accession>
    <name>A0A1Y2BLB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_502826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLB6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLB6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLB6"/>
    <dbReference type="OrthoDB" id="3230530at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="245"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="726" mass="79008" checksum="CB0CB6F5561F963E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BME8</accession>
    <name>A0A1Y2BME8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_513179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BME8"/>
    <dbReference type="InParanoid" id="A0A1Y2BME8"/>
    <dbReference type="OrthoDB" id="3365874at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="238" mass="26477" checksum="6C914448B9F47BBB" modified="2017-08-30" version="1">MPRGRHLDPHLPLTRELVRQRDFRARKSARLLALEDEVDQLRHENQAMRKELQTLRDGASPQASCLDSETLVVAARYLDTALNMIRPPVLPATKHHDDRAQWPHANPCHESLLHSPRLLSSSSPSSPWEPSGTLSSYDNHPASESSEPSSSRRSITMYHEATKHSERPPTSHTRTVTVPPSLTPPTSQPTSLTSLKTQESMSSSPVPIVHGTLNPGGDQCCYGWVDCEQDDHNPDTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BN02</accession>
    <name>A0A1Y2BN02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_555693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BN02"/>
    <dbReference type="STRING" id="71784.A0A1Y2BN02"/>
    <dbReference type="InParanoid" id="A0A1Y2BN02"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16667">
        <property type="entry name" value="RING-H2_RNF126-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="487" mass="51241" checksum="E94BF9C55E6D46B7" modified="2017-08-30" version="1">MSSRPSPFWLCHECGAQMRPLEVNGVKHCASCNGEFLEILDPEVNPDPYHELPPAPPVRPSTSPPPSGQSRSSLEEEQHAEGGGFMQHLFGSLFGAAASNAGQERAGPDPSSPGGSSAPRTGVSGLGQNQGAGGRTFTWNFPGGGQGRVVFGTMGGQMGGMGQVGGPFGPGGDDGLDAFFSGFGARPGGQQNRAGGLNDPMAGDDLLRGLMEIMSGEPGVMPPFLTGAPQGRANPGDYVMTQQGFDQILEQLMQAAGPQGPIPASEVVIEGLPRITFTEESLEKSVYKDCPVCKEDFTVGDEVMRVPCAHVFHPDCLQPWLKINGSCPVCRFSLVPEDGNRQNPQATQAQAPSGGLTSVTDILQRLWGQGGAPSNPTSPTTEQAPPVNLTSQLSTSVPPPPAPQPSPPPAVQPQSAADTPASTSEGQTEGTPTSGAPVEVDLEGPMLSSAIPADYRERHRQRELERERERERQTQQNSHDPYVDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AD00</accession>
    <name>A0A1Y2AD00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_555363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000136">
        <property type="protein sequence ID" value="ORY20428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AD00"/>
    <dbReference type="InParanoid" id="A0A1Y2AD00"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="309" mass="33376" checksum="4162410B6579D652" modified="2017-08-30" version="1">MSESQGPPDQEDVPVASSSRLPLPPQAVSSPSVDPATREDSAGDEDNRDKTPPVYDINQYVQLGEEFDRLKGHMREGLQTMIEAAYEGLSGVEDPEYQRTISDLIRDRLSLFEDDLKNSNTGRSGASQYDRGIAGSDARGVAEGSGGGVAEGSGGGGAEGSGGVPDRSNSVDSIDLIITDLLPRSGSLELKPLATLSDQQLIDLFYSVGSDQVPPFSSLPEYENKEPLAQQLTGIPDNPMYAAQRGEFRSLIYGSISDYVDRMRVERSDQAESDNDSQEDEDYGSDEESVQVEGREDSSFVGEDEDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE65</accession>
    <name>A0A1Y2AE65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_562859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000125">
        <property type="protein sequence ID" value="ORY20792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE65"/>
    <dbReference type="InParanoid" id="A0A1Y2AE65"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="387"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY20792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="46709" checksum="BC8990903B9D0636" modified="2017-08-30" version="1">MSFVSNFYAHTFAALSTGEELSLNPMSTAESEFCGFLNFDGEEPNQVDDLLPTAVANSPSGQSSSTENSADLDNASFTPPVMPIDHKDPFTYSAPSLDDYSFVPFTNQPDPAMGSDPTMLATFGEAFSQTAANTTVSPADLGFLNATDFFNFSQPAPAQTRTVNELYADLAASLGESFTDESPVAGTVAPASLVSSPAPFMKRKFSESSAASDPDPPSKRKVGRPKGSTNCKSKSKSKSASPTQPSTALPVHGSLDPQIPEQGSIYVPNATWQADEAGLGLKYDPVTNDPIFPAVGQSSVAVAGKFGGINCLTATGFDIDEANKYVKAEEDGILKGPLQRFWEAIRLWINASEDQVGRMDSAGNVIRKLDPALYKTARAYCCKVYAERKASADVVRAKRQQEKVEKELREKEIAELKAENAALKAQVARLMSRASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEQ9</accession>
    <name>A0A1Y2AEQ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_474886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000126">
        <property type="protein sequence ID" value="ORY20757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEQ9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AEQ9"/>
    <dbReference type="InParanoid" id="A0A1Y2AEQ9"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="37"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY20757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="389" mass="41485" checksum="D590B3D385F03B33" modified="2017-08-30" version="1" fragment="single">MSTLAASSKDVDAHTSGGVDGGTSKHHWQGVLSSALDAVGHTPLIHLERIQEEEGLECNLLAKCEFFSAGGSVKDRIAKRMVEHAEKDGTLVPGKSVVVEPTSGNTGIGLALACALKGYQCIITLPAKMSLEKEVMLRALGAEIVRTPTEAAWDSPESHIGIAKSLRKAIPNAVILDQYSNPNNPLAHYYGTYEEIMYSLETSSLPRKDITLLAAGAGTGGTITGIARAIRDVEMRALSSGKDISRTTVLAIDPEGSILGGGEPGNYQVEGIGYDFFPEVLDPNPPVVDEWIKTNDTEAFAMTKRIIRTEGLFVGGSSGSALSGALRYLKSPAGSRIASDKSANVLVILPDGVRNYMSKPWFLDIKADESHETLRVKIRNALGRDLGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AF96</accession>
    <name>A0A1Y2AF96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_554190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000117">
        <property type="protein sequence ID" value="ORY21166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AF96"/>
    <dbReference type="InParanoid" id="A0A1Y2AF96"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="61" mass="7011" checksum="19FDBD520024B795" modified="2017-08-30" version="1">MSQNETPSLTPTPAREAEPTIPQRPTHDGTRKLYYRSDLDEVESDIRGFHIDPAVRVSFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFG8</accession>
    <name>A0A1Y2AFG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_553978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000115">
        <property type="protein sequence ID" value="ORY21246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFG8"/>
    <dbReference type="FunCoup" id="A0A1Y2AFG8">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFG8"/>
    <dbReference type="InParanoid" id="A0A1Y2AFG8"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000899">
        <property type="entry name" value="Chromosome 15, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY21246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="567" mass="61651" checksum="2EA58A4DD25EF5CE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFP0</accession>
    <name>A0A1Y2AFP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_63646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000111">
        <property type="protein sequence ID" value="ORY21428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFP0"/>
    <dbReference type="InParanoid" id="A0A1Y2AFP0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="276" mass="31029" checksum="6C9EFF36F28F72D5" modified="2017-08-30" version="1">MTLFLVRATLTWNHSMRVQGTVESAFPSFFIYHVLRAKDVSIAEKSGNKKYIKALKAKAKFDATVAKSLSSTFKESPAFTHMSTLMNRLNGFAQSDDLPFLVNFTAPTGDPSSDATVKRIEKFRDFLLPTVANKIFPIDASILETRADLYYVSCQRTLLNSDLFRHHDPSLLLDSVEEIGVNRKAYKQEVIQTFDGESFASDPSTRNATQVAERFRTWVERNRSTNNELIFGTGGEQSLDHRNPGELEASEPAPSTRRSLLQKATHMVGKFRGQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ09</accession>
    <name>A0A1Y2AJ09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SacI homology domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_551568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000092">
        <property type="protein sequence ID" value="ORY22516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ09"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ09"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ09"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="173"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="562" mass="61223" checksum="2E89B0A0FF14AC90" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJC1</accession>
    <name>A0A1Y2AJC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_508050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000090">
        <property type="protein sequence ID" value="ORY22616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJC1"/>
    <dbReference type="InParanoid" id="A0A1Y2AJC1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25884" checksum="FE92A4DE9A0C3180" modified="2017-08-30" version="1">MNSLSLHDTASIYNRMVAVALMGLTLSGSTQPIRTQQPSDHAPIVNFAMPKPSSLKKAPQEASDEHWSDPRADIVIVSSQGMRFRAHRYNLSKARIYRLVEHYECVALKRVVADSIRRTATQGPWEHFLIAANQNDIALARVSLTAMSQAADLKKFEVLPDFFLAIEELPPAWRTALLVARFQKEDHKKNKKNGEKNDDIEGSGNYSARDWNRVAELFSPKGAQSKVSELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJY6</accession>
    <name>A0A1Y2AJY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative 3-ketoacyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_550676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJY6"/>
    <dbReference type="FunCoup" id="A0A1Y2AJY6">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJY6"/>
    <dbReference type="InParanoid" id="A0A1Y2AJY6"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY22826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="361" mass="39382" checksum="5F5B8A3F3A5B2EA2" modified="2017-08-30" version="1">MVADTIHLQTSSGLVHPSVNVLGYEIVVDLPIHTLILSAIGGAFVLRYAYSWLKLLAELTIIPGINVKSFQSRKTSTWALVTGCTSGLGLEFARQLAAKKYNIVLLGRRQEALDDLAKEIESKYGVQTKTVLVDMAQAESRSTAFAQVEALGKELDFGVLINNAGVSHEMPVTFAETPLAEIDNIVQTNFLGTFHLTRVVLPFMIARSKSGPKSLILNIGSMDGRVPPTLLAVYGATKGGLSVFSKALAEEVRGQRVLVNAVTPAFVISNMSKIRKSSLTVPTAKVFVHATLTSIGLARGAQGRPYEMTPFWAHAFMDYFVSLFGYASEMAGIKIVDYVHKDLRRRVLRKRARDAAKGKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM17</accession>
    <name>A0A1Y2AM17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_549074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM17"/>
    <dbReference type="FunCoup" id="A0A1Y2AM17">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AM17"/>
    <dbReference type="InParanoid" id="A0A1Y2AM17"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="498"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="839" mass="93905" checksum="78A278C0DF9DF2F3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM28</accession>
    <name>A0A1Y2AM28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_549041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM28"/>
    <dbReference type="InParanoid" id="A0A1Y2AM28"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="88" mass="9629" checksum="698E57E12607427D" modified="2017-08-30" version="1">MLLQVSRIAGLLGLVASGNHALAAARLSRHVHHQSQALLSSQNRTQRRAVAGDPPRLHTSSLLGMSCRSPWILARHKSKGKIAMWRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMH7</accession>
    <name>A0A1Y2AMH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_549234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMH7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMH7"/>
    <dbReference type="InParanoid" id="A0A1Y2AMH7"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="8">
        <location>
            <begin position="243"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY23427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="643" mass="72053" checksum="DF3E3965C7342480" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMU3</accession>
    <name>A0A1Y2AMU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_343002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMU3"/>
    <dbReference type="FunCoup" id="A0A1Y2AMU3">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AMU3"/>
    <dbReference type="InParanoid" id="A0A1Y2AMU3"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="157"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY23816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="419" mass="47113" checksum="8687FB2A78A97168" modified="2017-08-30" version="1">MPEYVPRHDRPPYYSSLPSPPPSQNLPSPRYASPDLDPDQPYPWTRQGIAMSLHGEEESGDTAEYGTQNVEYSQEQYDAEAAAEEQAYATEAGPSRKRPRPIEGEPSYQNGHASSSRPSSGSSFQPRQRQQLAQPPRPLRIADMQIIPSFFGLAPRNEFTKRVGDFLMEYCRGQQNIEIEMKLGTVMAVANPSQQPQRVRMPTWSEMILPPDYPTGGFVANMLKHRNKQLNQLLNTAAAAAQTSPVPVRFFRARHTDSFHDSGRGDKVRVTRDRDNEDQVVAVIKKKRLSNLNVYNPNQALDWRVSVSIEEPCKSLLLNMNQADAVSGEMPSGPITMIREKDRACYQHQLCQVDLTVVTTKSPKTGQATGVSYELEIEILDVPTLIAEGEKEIQGLPNRFDEMLQSCLDTVRMLVRNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN70</accession>
    <name>A0A1Y2AN70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_548453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN70"/>
    <dbReference type="InParanoid" id="A0A1Y2AN70"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY23946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="587" mass="65047" checksum="49E3FBC809EE2272" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANP1</accession>
    <name>A0A1Y2ANP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_547607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANP1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANP1"/>
    <dbReference type="InParanoid" id="A0A1Y2ANP1"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="3">
        <location>
            <begin position="149"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="633" mass="69919" checksum="7D2B5A204D60E3D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANQ8</accession>
    <name>A0A1Y2ANQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_547556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANQ8"/>
    <dbReference type="FunCoup" id="A0A1Y2ANQ8">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANQ8"/>
    <dbReference type="InParanoid" id="A0A1Y2ANQ8"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="30"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="311" mass="35282" checksum="95926089FBC936BE" modified="2017-08-30" version="1">MSMLRTIKPKNARVKRALEKREPQAVENEKTAIFVRGQSTSEKVRKAMQDLYALKRPHAINFSRKNDIHPFEDASSLEFFASKNDSSLFVTGLHSKKRPHDLVFTRIFDGRILDMVEMGIEEIRTISEFESPKSSLGARPLMVFHSDLFDTHPTYQQIKSTLLDFYNGHPVSDIPLNAVEHVISITAGPISDTAPLPRVHLRVYTVKLLASGSHAPRTQLTEMGPSIDFSIRRIQTADEEMMRQALRRPKLAKSDVEKGLGKKRKNIETDEMGDRVGRIHLGKQDLSKMQGRKMKGLKVRKEKPVSAGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANR2</accession>
    <name>A0A1Y2ANR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_507553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANR2"/>
    <dbReference type="InParanoid" id="A0A1Y2ANR2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="341" mass="35793" checksum="F426CC15903046F9" modified="2017-08-30" version="1">MAIEPPHQPSTAQSAASNTSSPPDTSTNGTAGSNGSAARLNPRPPVLFRHTLPIQNPPSTDTATGNGGNGSRSSGTPLSWIGPDRQRSLSVGATTLSTDALYLVPRRSAVGGSSGLRFPVGSSEDIPQRDNETPESHQSNVPRTDSPTVSSPEPSRTVSTREPNESNVSEVPQKLDLDWVMAELRPRVPFQVASPSLQKDMARTVCPGCVSGEHNTGMPSTTRTDHGTSGHRDFTAGHGLHSPQATEDNTSTNTRHGPTVEPESTIYTTSPASSTGQGITGGYGPASEANVRPPRHVDDDDDDDDDDDNTSRIESPDGNGENQLISGEIDPSCLSSLPVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANT5</accession>
    <name>A0A1Y2ANT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_472529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANT5"/>
    <dbReference type="InParanoid" id="A0A1Y2ANT5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY24211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="101" mass="11257" checksum="43358776B647EAA0" modified="2017-08-30" version="1" fragment="single">KRFEGNSRCYRCRVDDGACIVPTGRSKCVSCPNECSFKPSERSQRQLLRLSSAWSMLRTLRLLQSDHKEAAAIEEAQDDLARVAMVFGGLSHNGQIVDKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP92</accession>
    <name>A0A1Y2AP92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_547659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP92"/>
    <dbReference type="STRING" id="71784.A0A1Y2AP92"/>
    <dbReference type="InParanoid" id="A0A1Y2AP92"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="264"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="586"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="783" mass="84608" checksum="B2CA20E02C17E6FC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APF7</accession>
    <name>A0A1Y2APF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_472396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APF7"/>
    <dbReference type="FunCoup" id="A0A1Y2APF7">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2APF7"/>
    <dbReference type="InParanoid" id="A0A1Y2APF7"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="621"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY24376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="681" mass="75240" checksum="D0198032796DA82A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2API0</accession>
    <name>A0A1Y2API0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_547638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2API0"/>
    <dbReference type="OrthoDB" id="2564806at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="356"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="401"/>
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    </feature>
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            <end position="501"/>
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            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="62"/>
            <end position="81"/>
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    </feature>
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        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
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        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="387"/>
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        </location>
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        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="535" mass="56746" checksum="D9A116F07F4CD952" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y2AQ43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_546319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y2AQ43"/>
    <dbReference type="Proteomes" id="UP000193986">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="78" mass="9412" checksum="3C7C9AD4BB01FF59" modified="2017-08-30" version="1">MAQEPVPYHIPKEEKERKTFAVKKREKLEKASQQDLIKDSYPRENKRDCKEKGFLERKRRKKDRHVKAISRSIVKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ96</accession>
    <name>A0A1Y2AQ96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="13" type="ORF">BCR39DRAFT_472635</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ96"/>
    <dbReference type="FunCoup" id="A0A1Y2AQ96">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQ96"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ96"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000045">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000032">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="11">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="240"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="77"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="418"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="452"/>
            <end position="455"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="548"/>
            <end position="549"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="554"/>
            <end position="558"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="631" mass="70911" checksum="BC6B67BB1864EB9B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQH5</accession>
    <name>A0A1Y2AQH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_546370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQH5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQH5"/>
    <dbReference type="InParanoid" id="A0A1Y2AQH5"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="298" mass="32185" checksum="5772CB3A0D663E2E" modified="2017-08-30" version="1">MVSWSRLIRFVPAEDPSSILYGEPQGDDFGDIGALADDGRLKAAVIEVDSSGPLSDSAKLTETILTVGKLLGPLAPDDCTDIKCIGLNYKKHIEEAGRSLPPFPSLFIKPTTSLGDYNEVVPIPKCAQEGEADYEGEVCAIIGEDCKNVGVENALDYVVGYTAGDDVSARKWQRLKERAGGVPQWCFSKGFDKFAPLGPMIVSTEIIPDPSTLHMKVHINGEERQDTPVSDLVFDIPTLVSFLSQGTTLRRGTVIMTGTPGGVGCSGPEDKWSPLKDNDKIEISVTDIGTLRHTVKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQX0</accession>
    <name>A0A1Y2AQX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_545589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQX0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQX0"/>
    <dbReference type="InParanoid" id="A0A1Y2AQX0"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="5">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="767"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
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            <begin position="470"/>
            <end position="480"/>
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            <end position="499"/>
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            <end position="539"/>
        </location>
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            <begin position="542"/>
            <end position="559"/>
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            <begin position="560"/>
            <end position="593"/>
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            <end position="609"/>
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        <location>
            <begin position="610"/>
            <end position="651"/>
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        <location>
            <begin position="662"/>
            <end position="677"/>
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        <location>
            <begin position="705"/>
            <end position="731"/>
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            <begin position="779"/>
            <end position="797"/>
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    </feature>
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        <location>
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            <begin position="842"/>
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        <location>
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            <end position="881"/>
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            <end position="914"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY24864.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="936" mass="98329" checksum="95B9F9E6A77F137E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">BCR39DRAFT_545167</name>
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            <taxon>Naematelia</taxon>
        </lineage>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="110"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ORY25051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="124" mass="14020" checksum="ADFD971A34E3C978" modified="2017-08-30" version="1">MPKPELEFVDVQTHFKWERNKEGSSQQVLAYDADTGNITKIVTRDPGHEQFTPVQVHDFWEEVYIMDGALFDKGLNKWFRAGMYTCRPPGMLHGPYKACPHQGAKMFVTLTYPPGTKAAGSDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Homeobox domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Naematelia encephala</name>
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            <taxon>Naematelia</taxon>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
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                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y2AS95"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="2">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="444" mass="49848" checksum="453596BD32463925" modified="2017-08-30" version="1">MSTKDDTLQEHQGPQDAANLADEFPSPEPHHAAPIDMSHELANQAAAQAIEAAVAHAAQDNDDPSTFAHHHHHHHHQHQHTTASSPTPPPPPARFHESTPQGALTNNEQIAILRESYARNPNPGKAELETLAIKTGRPWNKIREYFRQRRNKLRGLDDLAVMEEPGRATGWLQVTYRSAPTTSFVSQLNLYEAYKDRFDPYSTSTPLLGGQELIALACATFPGCEMAKDESDYVLRGLREKDGAEREAWERGMEGLVEPLRGSSWLLSHYQHPTDPSAPATLTQTELYTSYATRFSSLLPQPEPSTSDFDTAPGGTSSTDLSEQDLETLFSSAHPQQPQQSPQQQQNQAQEQEQAQISPRENRLLNPVELINLARMTFPKCEPVVDEQGRFVIRGLERRDWVERGRHVRPDDMFPFALANGMFSLSSLSSLLFSRVKDTKRHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASH3</accession>
    <name>A0A1Y2ASH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine triphosphate pyrophosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_291706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASH3"/>
    <dbReference type="FunCoup" id="A0A1Y2ASH3">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASH3"/>
    <dbReference type="InParanoid" id="A0A1Y2ASH3"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="249" mass="27478" checksum="3AFEC60A543BB592" modified="2017-08-30" version="1">MSIKRPSPVLPTSLPLPIFKQLQNRRIVLASSSPRRKDILETAGLRPEIIPSTFAENLPKSRFQGHLADYPIATAGEKALEVYERLIKEDDRDPADLVISADTVVIFPPEKDTQENGAAHGEISEILEKPINKDEQIRALLSMSGRSCEVITGVTIVYPCVEAPGYKLESISCSTLVQFYDNSRKVVKAYVDSEEGLDRAGGFAIQGLGGILIEGIEGNYDNCVGFPSAPFWRWMSELAEHGVFKEAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASW3</accession>
    <name>A0A1Y2ASW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_543513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASW3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASW3"/>
    <dbReference type="InParanoid" id="A0A1Y2ASW3"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="2">
        <location>
            <begin position="325"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="483" mass="51627" checksum="CDBAC4A8A4C20E92" modified="2017-08-30" version="1">MAKLGGIKFGAPPATRKQSSLSPGPPQSPLEEPTSPLEAPMSPVKVSSSITEDVTEEATAAAPPMGDDETPDQESARRRATLARLRAGGTLGFGMFGHGPAAISASDDTRGLEQELETQEAEAAPPPPPAPSKRTSLPPPPADEGPRSPPYSPRQSLPPPPPVEEEEDAPPPPVSAVRPPQPTTSPVPLSPSTPTRRPPIPASEKRYSQHQPHPIAIPEDAPPPPSQSFDSQLVNEPAVMMMNQQSPVSPPLPPPLPPISTRPHTQPESPRRSMSAASRISRTSTTEHSPVLPHGSPASRQPSRQEAFPTPEQPVEAPRPSMNQGRPGYDQLVAASRDGGARLARAAKAMFDQGKRGHFGDGSSAGFVMVAIDQAQLARPTQEWGQVVFEQEGSSVMKRYDEPRPGDIAAFYDAKLKGKKGLAGYSQHVGSVEEPLLGVVVEFESKHKQKMRVLQVERGVPEEVSYRCEDLKSGKVIVYRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU85</accession>
    <name>A0A1Y2AU85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_273539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU85"/>
    <dbReference type="InParanoid" id="A0A1Y2AU85"/>
    <dbReference type="OrthoDB" id="2536450at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013345066" evidence="1">
        <location>
            <begin position="18"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="303" mass="31123" checksum="6ECB664DB9514E52" modified="2017-08-30" version="1">MRVSSTIVLAALGSASAVVGQLSIPSSFMGLTFSAACQQAILGVLTTGPFAECTHFADVLPALVSNISVVPVLDKFMSDVCYSAACSNATLQQASTTILSGCASDLSGEGLPNSTVTTAFSTYPLVREILCLKTSDPYTNASYGGVLGNPPIPISSAYNTTGGVFCVTSLLTQLSAYFGTNLTIPFVETIVKGGNSTALKLAEGIQSNIICNGCIFGALDVVEEAYPGVGSVPISKIYGLLNRTSPVNTTINGFVNGTCAYVPLNATSNGTLPTNISVSIIDSTFPYNLTNGTTTFLPNATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUG2</accession>
    <name>A0A1Y2AUG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_542553</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000052">
        <property type="protein sequence ID" value="ORY25920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUG2"/>
    <dbReference type="FunCoup" id="A0A1Y2AUG2">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUG2"/>
    <dbReference type="InParanoid" id="A0A1Y2AUG2"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="18"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="16">
        <location>
            <begin position="655"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="17">
        <location>
            <begin position="806"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY25920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="919" mass="100188" checksum="66EEEF9B95898348" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUL4</accession>
    <name>A0A1Y2AUL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="7">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_272465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUL4"/>
    <dbReference type="FunCoup" id="A0A1Y2AUL4">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUL4"/>
    <dbReference type="InParanoid" id="A0A1Y2AUL4"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="583" mass="63288" checksum="297BEBD99E2C8DFD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUP4</accession>
    <name>A0A1Y2AUP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_542101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUP4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUP4"/>
    <dbReference type="InParanoid" id="A0A1Y2AUP4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012621195" description="CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="257" mass="25176" checksum="335DFC2535BC8EF3" modified="2017-08-30" version="1">MLPSLFLLALPLASAFNLGLHSYGERQSQAPACLQDCITEEAENSECRTASNTTCLCTRSDVAGVIQSCADASCSTSELQTALQYYENLCGVSIGGSNTSSASSSVSESTSSSSPSSTKTSAASSSKSSASASSSSSSASSSSSELVLSSSSGQSSSATETSSSADSSATSAAAAVTTVTTTSSSTSSDSIVIVTTTSTDSPSSTPTSTAIPTSTVHVSASAAAASGASTAGASQVIHVGWQTGFAGVILVAAFMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUX4</accession>
    <name>A0A1Y2AUX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_470584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUX4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUX4"/>
    <dbReference type="InParanoid" id="A0A1Y2AUX4"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="105" mass="11201" checksum="3F96B063AD394E23" modified="2017-08-30" version="1">MSILRSAFITSRQGYALRALSTSSPRSKTVTETVKDTADSINKKIGKTLASGLDTVEKTTDSAKQTVCAKVSTETAESARLESNHALGKAAGKVRDAKDELEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV45</accession>
    <name>A0A1Y2AV45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_589709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV45"/>
    <dbReference type="InParanoid" id="A0A1Y2AV45"/>
    <dbReference type="OrthoDB" id="2564618at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="785" mass="86228" checksum="C06586C48659D081" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVC5</accession>
    <name>A0A1Y2AVC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_541046</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVC5"/>
    <dbReference type="FunCoup" id="A0A1Y2AVC5">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVC5"/>
    <dbReference type="InParanoid" id="A0A1Y2AVC5"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="49"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY26509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="378" mass="40680" checksum="5D0805566963457F" modified="2017-08-30" version="1">MLLSRPASRTLVSSLRSFQVPARSYNSAFGSSTPTSAFAAQKGPDGNYTVTMIAGDGIGPEIAESVKTIFATAKTPIKWEEVDVTPILVDGKTTIPPDAIKSIKKNTVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCVSIKGYKTAYDNVNTVLIRENTEGEYSGIEHELVDGVVQSIKLITYEASERVARYAFHYASENGRDEVTAVHKANIMKMSDGMFLTACREVAKDYPKIKYNEDLLDRVCLRIATDPSPYADRVMVMPNLYGDILSDLSAGLIGGLGLTPSGNIGRDASIFEAVHGSAPDIAGKGLANPTALLLSSLMMLRHMGLYEYADKIEKAALSTIAEGKHITGDLGGKASTKEYTEAILSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXG2</accession>
    <name>A0A1Y2AXG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_506624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXG2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXG2"/>
    <dbReference type="InParanoid" id="A0A1Y2AXG2"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="330" mass="36029" checksum="826585E06A252E24" modified="2017-08-30" version="1">MDTTLSPRLRHLLIKEDGRTGRLIHPEGYTPRESITELTPPLSPASYGFTPSPLEKPLRLPTPPTHAPLLPLPRLQHDRRPSTSIFTLLNDLHVDAPSTSFSSTSRSRQIGYGRYSPPVAPLSASHIQPPSGLDPHRRSSTAPRPDLFRRHSSHPYEYGVTTPRPATSYQPSDFAPVVGSRAPISRTTKACNACRSRKVRCDAGGSASGEPSTCSRCRESGGTCVYSGVQKKRGPCLGTTRPVQIPARPRRPSGRSSISSRDDVITPPDEYPSQTPSSSYGFPSSTDWTSSAPQSFDSNATLRARPATVDMYCRGLRWSRQSKLTMIVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY27</accession>
    <name>A0A1Y2AY27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_538275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY27"/>
    <dbReference type="FunCoup" id="A0A1Y2AY27">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AY27"/>
    <dbReference type="InParanoid" id="A0A1Y2AY27"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012395307" evidence="2">
        <location>
            <begin position="17"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="82"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="482" mass="53406" checksum="2B5231CFA00F5187" modified="2017-08-30" version="1">MSPLQLLFLGTGTSSGLPLAPCLTLSEPWPWSIAQTIPTSSAKSPPKGGFDPNGSWPSNIPCACCRSAVHRDVPEGWKNRRGNTSVVVRKKDKKGQWRNIVVDVGKTFREQATRFFPRWGVKTVDAVILTHGHADAYFGLDDLREWCTRQGKPIPIYLNRATYEIVANSFPYLVDKSAASGGGDIPTLQWNIIENEASFEVFDIHVQALPTHHGVYFRSPPETALPTAGSASTKVPPVKPVPEPLICLGYMFDREIVYISDVSFIPETTWDLITNRYDVRRDDNAKHDNVSDLIDGVKRLTSHSKAILPTPGMTPTRPRTPSSDFIPVQSVPSSFNRRSSSGGRLPILIIDALFPIRTHSSHFNLAQALDAAMRLDAEITYFVGSSHPTSHYMWQEICRSFRGEDGQRKDHPDNDQCKTLLRNLMADEQFSGTQDGKESFAQKLIHWGGRAEPAWDGLVVQVGAKDGGFQELENESAGGWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYQ1</accession>
    <name>A0A1Y2AYQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myo-inositol 2-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_497705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYQ1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYQ1"/>
    <dbReference type="InParanoid" id="A0A1Y2AYQ1"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="137"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39344" checksum="D927BB8355A88AEB" modified="2017-08-30" version="1">MSGPKLPVAVIGIGRMGQSHALNFAYAVPRAELVAVCDPRESALDRARKELPPNVQGFLDVKECFAKSGAKAVLIATETASHAPLAKLAMESGLHVLLEKPISIDVETSKEVVKVAEAHPELKTMVAFVRRFDESTRELKRMIDDGEMGEVHLLKSASNDPYDPSGFFVNFSGTSGGIFTDVGVHDIDVARWLLDVANGCPNPAKQVHRVFAIGQSVRHPELKEMGDADNGMGIVEFTNGTVFMCHMSRTQMNGHECWAELFGTEKKVVINGNPQLNKLEIRDKYGVRTESTATHYLRYKDAFVRELQDFTACVLDNKPLPVSLRDALEASKIATAFTLSYHKGVPVFFDDQGEVTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYT5</accession>
    <name>A0A1Y2AYT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exocyst complex component Sec10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_536888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYT5"/>
    <dbReference type="FunCoup" id="A0A1Y2AYT5">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYT5"/>
    <dbReference type="InParanoid" id="A0A1Y2AYT5"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="70"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="206"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1028" mass="112320" checksum="A0276A0A6DB84342" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ87</accession>
    <name>A0A1Y2AZ87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_538739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000040">
        <property type="protein sequence ID" value="ORY27175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ87"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZ87"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ87"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="33"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="517" mass="57476" checksum="0854CC1B94C93AE2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZP0</accession>
    <name>A0A1Y2AZP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_468725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZP0"/>
    <dbReference type="InParanoid" id="A0A1Y2AZP0"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="523" mass="58145" checksum="ABF92532E4B6A687" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B052</accession>
    <name>A0A1Y2B052_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_576773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B052"/>
    <dbReference type="STRING" id="71784.A0A1Y2B052"/>
    <dbReference type="InParanoid" id="A0A1Y2B052"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="457" mass="50354" checksum="10D6D699274E56EE" modified="2017-08-30" version="1">MPIATPKVSPWGKEVLPPTWSLSAWQRSTREDPLVNRGRDEALPEFADVVIIGSGLSGAAVGYNLLTASNRPASVVCLEARECTSGASGRNAGHCRPDTFRGFKEYADLHGEEQSAMILASESITWRRMDAFIKEYAIDCEWTPRLTVDVAVGQEFKNYMEESIAQAKRADAIKEDWMYLDPAATQQRTSLPSTLGSYGWQAATLNPAKLTYGVHRVNLTLGGYQLFTHAPVTSVDEAVRGEWLVQTTRGALRAAKVVFATNGYTKLILPELAGLITPLAVQALQVGEHEPKLESSMSLRYGDRRYSVAQRPNGKVVLSNTMTWVGQTEAEWQSLYENMDDSTPIEAATKDTMDEWLKHVPDADPNGFEFAWRGILGMTPDRAPWVGAIPGKEGQYIIAGMNGHGMARIFHCAPCAASLVLGGQWDETLPKAFECSQERIDTVRQKVKEGLLGYQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B081</accession>
    <name>A0A1Y2B081_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_536605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B081"/>
    <dbReference type="STRING" id="71784.A0A1Y2B081"/>
    <dbReference type="InParanoid" id="A0A1Y2B081"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000363">
        <property type="entry name" value="D-isomer specific 2-hydroxyacid dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="141"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="354" mass="38653" checksum="85DD76A6311E74A5" modified="2017-08-30" version="1">MTEYKTAAVTIEISDDKLAEIKTKFETVHYYPDGEFPDEYLASVDIWYPGLPTKVTSVEQVPRTKIVQLASAGANVFLAKDIMKTEQGKQQISVCSASGIHSLSIPQYIVANIVNLYMKAQVYTHLARTHAKWPQRTEILKMVNTAKAGEFNRSLFGKTVGMLGYGHIARETARLLKAFNCEIIAANSKGDRRPETGYAIPGTGDPDGSLPSEFYSTTDPKSFEAFLSRCDVLVASLPSTPATKYMLTPKHFDYLPTGAILINVGRGDLVKSEYILQALDAPNGLAGAALDVTDPEPLPDGHPLFTHPHVIVTPHASGNFEGYYDGGADVLLFQIDRLNRGESPVNVVDPAKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1D3</accession>
    <name>A0A1Y2B1D3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_534486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1D3"/>
    <dbReference type="FunCoup" id="A0A1Y2B1D3">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1D3"/>
    <dbReference type="InParanoid" id="A0A1Y2B1D3"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="52"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="368" mass="41051" checksum="05C52F994734F649" modified="2017-08-30" version="1">MEALKPLKRAAEKERRRANRKALREKANAGLLSLEEQALVDSRKQLRQARRGARGLAEADMQGDWKGGVVVDLGFDDCMTDQEIISMTTQLGRLYSSNRTASRSVATVLHTSFSPNASPRLWEKMRKSNWEKWTRSSWWGLGLDELVKAFKDHPDHIQSDSFTPTDTKPSETDLMMNSSTALNTDRSAANGKGNPSDLIGDGTDTDLLLSNLSHPHLPSPFTSKYKLVYLSADSEEELTTLSEDEIYIIGGLVDRNRFKNICQDKADKLGIRTARLPIGTYLQNLPTRKVLTVNQVFEILVNYIATQSWKEAFEAVMPQRKFNVGKPRKYNKDDGEDGVGDDGDGDEVEQVGNIATADEIDEEAALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B299</accession>
    <name>A0A1Y2B299_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_534407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B299"/>
    <dbReference type="STRING" id="71784.A0A1Y2B299"/>
    <dbReference type="InParanoid" id="A0A1Y2B299"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="104" mass="12302" checksum="CCC50A205DF75079" modified="2017-08-30" version="1">MQALSRREETDLMDRMRKEALVKCEDVVREYVECTKSRTVTIGWACKDQLKAWTECMHRHVTQETIDAAKLDYLATRGDKEKEAIERLKKERVESYKRHAGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2C5</accession>
    <name>A0A1Y2B2C5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_533457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2C5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2C5"/>
    <dbReference type="InParanoid" id="A0A1Y2B2C5"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="234" mass="25969" checksum="A4AA31860BEF1432" modified="2017-08-30" version="1">MTQPRIVLYSALLCPFAHRARIALKASGAVYETVEIDLKNKPAWYAPNINPASKVPAISYGAPPDSDVTKPPAGTFLLPESALVVQFIASLYPQIDYKDPIIRAKASFAQLQWDNLVAGRWRKYQFEGSEQDLEPLLEGLKQFSDSVPEEILGDEYGVADIILGPFVTRLFIFANEDIGKWAPGSGPKLVSALSGPEYDKLRKLGAKLDKWPALQETIDNDILVKKFTEILKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2E4</accession>
    <name>A0A1Y2B2E4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_559307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2E4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2E4"/>
    <dbReference type="InParanoid" id="A0A1Y2B2E4"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="371"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
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            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="540"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
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            <begin position="576"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
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            <begin position="612"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="648"/>
            <end position="685"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="859"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="718"/>
            <end position="748"/>
        </location>
    </feature>
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        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY29008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="889" mass="95056" checksum="3C52AC7AEE42C6C1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2K6</accession>
    <name>A0A1Y2B2K6_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BCR39DRAFT_181685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2564766at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="146"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
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            <end position="125"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="225"/>
        </location>
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            <end position="248"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="420"/>
            <end position="440"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="ORY28966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="540" mass="56249" checksum="0F2A9D3715C10DD6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2Z5</accession>
    <name>A0A1Y2B2Z5_9TREE</name>
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        <submittedName>
            <fullName evidence="10">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">BCR39DRAFT_534734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eS31"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
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    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
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    </dbReference>
    <dbReference type="NCBIfam" id="NF001669">
        <property type="entry name" value="PRK00432.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S27"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="159" mass="18011" checksum="15FAD3844BA29E58" modified="2017-08-30" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKNYTTPKKIKHKRKKVKMAILKYYKVGSDGKIQRLRRECPAPTCGAGVFMAWHKDRQSCGKCGLTYTFEPGTKPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3U7</accession>
    <name>A0A1Y2B3U7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase Rpc34 subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_588445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3U7"/>
    <dbReference type="FunCoup" id="A0A1Y2B3U7">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3U7"/>
    <dbReference type="InParanoid" id="A0A1Y2B3U7"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="577" mass="64570" checksum="9F303057E96EAB5F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B406</accession>
    <name>A0A1Y2B406_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_187378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B406"/>
    <dbReference type="STRING" id="71784.A0A1Y2B406"/>
    <dbReference type="InParanoid" id="A0A1Y2B406"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF21">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE YFCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="139" mass="15097" checksum="816B6324C9921B8B" modified="2017-08-30" version="1">MADPASLSESGLPPCLDISKSCVLYTQWRSSSSMRVRISLEFKRLCPSVHTIDLDNIPEGYKVLNPSLSVPSFVVDGVLMTQSLAISEYLEDRWPDRGLGRLLPERADQRAAVRAVCCSVDTAGAESSDTTCSKAPSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B438</accession>
    <name>A0A1Y2B438_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_532313</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B438"/>
    <dbReference type="STRING" id="71784.A0A1Y2B438"/>
    <dbReference type="InParanoid" id="A0A1Y2B438"/>
    <dbReference type="OrthoDB" id="2560721at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY29320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="512" mass="56001" checksum="412552DCBA8E9DBE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B487</accession>
    <name>A0A1Y2B487_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_532023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B487"/>
    <dbReference type="FunCoup" id="A0A1Y2B487">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B487"/>
    <dbReference type="InParanoid" id="A0A1Y2B487"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="68"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY29536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="545" mass="59353" checksum="A661519BF993B882" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4Q7</accession>
    <name>A0A1Y2B4Q7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_505396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4Q7"/>
    <dbReference type="InParanoid" id="A0A1Y2B4Q7"/>
    <dbReference type="OrthoDB" id="2573023at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="319" mass="35430" checksum="215183441F8CB8F3" modified="2017-08-30" version="1">MTMSTPIVTDSPHPLTRPLYPSHTAPAPKRLRSCLSPTRLSRSSSPVEDLSMIQLASNSSDGWRRVKSVRWEGEDETDDEGSVVKSYHLTWSATEYDRTPLDPPSAAERLCVLPERNSRCLRTSLESFDTILSCLEAEEEAGADEMFHRTLLPPAIQEDKDRENEEQNEDEDCGDAEWEECMERRRMMFAHMCRSSEGDERYPEFDGYRSISSTLVELLRQGGEYEGIVHAEPEEMESGWHGLDESDETAQTPSLVWSSGSEMGCSSAGPPSPSPTVVGPEHVSDMMIPLTKGTEAEGGVKPLMAGMEVEVEVVTPSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6C7</accession>
    <name>A0A1Y2B6C7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_460490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6C7"/>
    <dbReference type="FunCoup" id="A0A1Y2B6C7">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6C7"/>
    <dbReference type="InParanoid" id="A0A1Y2B6C7"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000067">
        <property type="entry name" value="Endopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="136"/>
            <end position="457"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="167"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="570" mass="59529" checksum="CBAB12D9AECB7046" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6D8</accession>
    <name>A0A1Y2B6D8_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BCR39DRAFT_529753</name>
    </gene>
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        <name type="scientific">Naematelia encephala</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6D8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6D8"/>
    <dbReference type="InParanoid" id="A0A1Y2B6D8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="420"/>
            <end position="504"/>
        </location>
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        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
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            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="653"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="660"/>
            <end position="670"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="708" mass="79252" checksum="C3014ACC986FAB67" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6Y9</accession>
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        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">BCR39DRAFT_529121</name>
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        <name type="scientific">Naematelia encephala</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="71784.A0A1Y2B6Y9"/>
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    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="796"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY30601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116384" checksum="40C48A051CD8FA32" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6Z6</accession>
    <name>A0A1Y2B6Z6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S2, flavodoxin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_529185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6Z6"/>
    <dbReference type="FunCoup" id="A0A1Y2B6Z6">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6Z6"/>
    <dbReference type="InParanoid" id="A0A1Y2B6Z6"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="257" mass="28557" checksum="66C83ED009CF203F" modified="2017-08-30" version="1">MQAFRRRKAAMHINTPFIPPSSKPIPSPSPLNLTLSTLLASGAALGHSPSLLHAAFAPYVYGTRSGLSIIDLDQTLPLLRRAASLVRDVVKADGIVLMVGTKPSLRKMLEKGKERLGDNGYIARDWVPGLLTNTESIFGIKPMLDRGFLPDLVIFLNPADVRPGLRECVIRNIPTVGIIDSDMDPRNVTYPIPANQESVRTAELILGTLTLAGQEGRRMRLKEAEAKAEREKERRARDREDMRRRAPPRRGRDEVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7L2</accession>
    <name>A0A1Y2B7L2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_494399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7L2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7L2"/>
    <dbReference type="InParanoid" id="A0A1Y2B7L2"/>
    <dbReference type="OrthoDB" id="429183at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483:SF1">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="74"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="288" mass="32285" checksum="24D55FAAE03D4FEA" modified="2017-08-30" version="1">MPTDDPTSRLSPSDFEFHDEEDGDEELNSQAYRPTSTSTVPSTARSTASMYHLPPSEQLRGVANRIIFSRYYILFYLVMFGLGVGTVVLSLIATHNKSCPPVAWHILEVVVNVLMVLEVGTRWVAYGKKYPLTLLNIVDLLLVLFCTLTLILVFHNPCSTGTRQEEVLDTILLVIRNLVQFLRLGHILRRSGHSLLNPPKPIDLSQARTASLALDLDLDLSDEEAVAERQLGRSLVGSRTSRGNYEPIFQDTTPQEDDEPQRQPLGVKNNARSDQLTAEDEEVWDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8L6</accession>
    <name>A0A1Y2B8L6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_107469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8L6"/>
    <dbReference type="InParanoid" id="A0A1Y2B8L6"/>
    <dbReference type="OrthoDB" id="2564578at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY30837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="102" mass="12042" checksum="B84EAF96996E1B09" modified="2017-08-30" version="1">MDEMIKKHLWSAIKLDGRLSSRGSYGVQYHAKMLMKKGLGKQVEMSEDSMMIDIDPVNWDVGYRMFDIYVVISKQETNKERREIKIYCTYTVLQCRYITCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B958</accession>
    <name>A0A1Y2B958_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_526283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B958"/>
    <dbReference type="STRING" id="71784.A0A1Y2B958"/>
    <dbReference type="InParanoid" id="A0A1Y2B958"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="461"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="688" mass="74200" checksum="777A3D4E28CD26EC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9D2</accession>
    <name>A0A1Y2B9D2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_465977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9D2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9D2"/>
    <dbReference type="InParanoid" id="A0A1Y2B9D2"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="547" mass="60671" checksum="43BB22A7C62CBE00" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAP3</accession>
    <name>A0A1Y2BAP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COQ9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_479444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAP3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAP3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAP3"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="41884" checksum="15D1F4C0EC4149B4" modified="2017-08-30" version="1">MSLRATILSHSLPHLPTHSFTRSTLVHALTALPPSHPDYREPQVVENAIDTIFGPGNVGAAKALVEAWEDAGRDDMTGKQGGLKEILQRRLEWSAAVGEHLVEVSCITIGSWTDHKLLIYLVSHLTPLSSIKDWTTCCGGACLIVMLILLLSIQAYANLSTPTSPPSIPLPSLPTSLVSRLLTALRPPPLYSPPSSSSSSSFSPSPSFSSSLSSTSPSSPSSASSSSSPSSTSSSSSTSSLSFSSFLSSSQLALITINPLGPFSYAFRIADTAMTANERLLLEQQQQQSNLRRGAWGEPLGAGSEWYISRAGLGIVYLIAESNLLRPMPSDQPVSRGINPYLPQAIESLETGIDRYNQVMNTLENSEQGLGEAAGYLGFLGRSLQGIIRSRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAZ8</accession>
    <name>A0A1Y2BAZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_465525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAZ8"/>
    <dbReference type="FunCoup" id="A0A1Y2BAZ8">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAZ8"/>
    <dbReference type="InParanoid" id="A0A1Y2BAZ8"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="180"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="361"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="470" mass="51858" checksum="002EB4335280B6F3" modified="2017-08-30" version="1">MPSLAQQLKQLEAEDTPPRIVDPESAYTSIDALEVGTREGDEGREHYLDVGPSRLRQGLGNGNGSDQTLLSEKYGGKRVGRMKIFDDEDEDEDEDEEEERGDDGGNSDDQEEDDREDDEEDDDDEEEEEDEEDEEDEEDEDGEDEDDPVEGEEEEASHGPRPSARTLDPLAALRESRAKDIEKGKAVRAQKQLFESLLTMRITLQKAVTSTLKLPTPLPEDPEGETEAKRAEVLLSLAKLNERLTGLRRDAALPGVEFPENVGKRKRDEGNELEEGYWMNAGRESLEMTDATEPQLVSVLNKWSNKIQAATLQMGSKQAGGSKFLQSTKDGSSGIMDAIEAGLASKRDSDKSLFEHEEASYRTLLREVIESRTGSSAGPDLSHLRREKKKKREAERGASKGRKLRYTVHEKAQNFVVPIPLRHGWHEEQVDELFSSLLGGAGLKGAGAEASTGALLSGSAGQGLQGLRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB69</accession>
    <name>A0A1Y2BB69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_79834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB69"/>
    <dbReference type="FunCoup" id="A0A1Y2BB69">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB69"/>
    <dbReference type="InParanoid" id="A0A1Y2BB69"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="232" mass="25639" checksum="74CCA89C6D75C24B" modified="2017-08-30" version="1">MDEIQHPREWYPLESSPEVFTHLARQWGLAEQYSFIDVLGLDPELISLVPKPVHGVIFLFPDTPEIVKKRTGEGPCMPVGPKIEPLWIPQVDVGHSCGTFALVHILGQTGLASGLNEFFKSCREAQPAERPKLFGSSPMIYKAHHSAITAGQTLIRPEDWDECDHFLSFVHHEIDGKIHLVELDGNISRNGPLDRGETQSGDLLEDVASAVKEVYLTAGGESLHFSMIALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBN8</accession>
    <name>A0A1Y2BBN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_524461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBN8"/>
    <dbReference type="FunCoup" id="A0A1Y2BBN8">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBN8"/>
    <dbReference type="InParanoid" id="A0A1Y2BBN8"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="376" mass="40419" checksum="F83090DB372AB0E5" modified="2017-08-30" version="1">MSVRKSPPPAGPGYALTKRARVDDEDAEDPNSMTLTVASSGEGQRKNALIRTIKRTSGLEAPIVSLTGAHGGEITACKFDPSGRRLAACSVDRAISLWNTFPPHDNYGILPNVHKQAILDIAFSIDSEVIYSGGADGMLIATDLTNGERLVRYAAHYGPLNSIAVGVSGGRELVLTGGDDGIARVWDLSLDINHPVAEFDDGRDCPVTAVEWSTDGNQCFVGGVDNEIKVWDLRTTKVVYTLHGHTDTISSISLSPNGHYLATYSLDSALIIYDVRPFSSDPMRVYRSLTGAPAGFEQTLIRVCWSRHDGGARIAVGGGDRTVTVWEVETGKVLYKLPGHKGTVTGVDFHPREPIILTGSKDTNMLLGELDAQDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBQ7</accession>
    <name>A0A1Y2BBQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_587007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2BBQ7"/>
    <dbReference type="OrthoDB" id="10685742at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="771" mass="86606" checksum="2B11BD92E9F9529B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBV0</accession>
    <name>A0A1Y2BBV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_525132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY32000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBV0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBV0"/>
    <dbReference type="InParanoid" id="A0A1Y2BBV0"/>
    <dbReference type="OrthoDB" id="2596887at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="661" mass="71541" checksum="34CB7E1714A4D96B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCL9</accession>
    <name>A0A1Y2BCL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_522843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCL9"/>
    <dbReference type="InParanoid" id="A0A1Y2BCL9"/>
    <dbReference type="OrthoDB" id="2564985at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="248" mass="26827" checksum="3BC5D6F08C13964B" modified="2017-08-30" version="1">MATMEDLVASLGGNMHVSQDGYELKALHEFLSQNLAMPPITPMSPTAHFHGMPSSRSASVTRKPTSLPSTYPYTDALNQPLPTPSAYSMYPAEHDDEPMFSPRPGTLRRSSSYGFGTPVNAGLSGFESDAFAPLAFGGPSAKPPAGSSNPWAAFQKQPTQVQVQVQEVQGSNDPEPESQDYGGDEDYEDEDDERMMMDEDEADESMMDEDEEEEKVERVMGIGGSGQRSSWGSFGGQGAAGWDRGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCS3</accession>
    <name>A0A1Y2BCS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_564255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCS3"/>
    <dbReference type="FunCoup" id="A0A1Y2BCS3">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCS3"/>
    <dbReference type="InParanoid" id="A0A1Y2BCS3"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="10">
        <location>
            <begin position="602"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1160" mass="130707" checksum="F6EB4BE0EFACCFC7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD77</accession>
    <name>A0A1Y2BD77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_557940</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY32015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD77"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD77"/>
    <dbReference type="InParanoid" id="A0A1Y2BD77"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="12">
        <location>
            <begin position="39"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="13">
        <location>
            <begin position="359"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY32015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="568" mass="60879" checksum="D17699A9ECEA18A6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD98</accession>
    <name>A0A1Y2BD98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Survival protein sure-like phosphatase/nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_522648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD98"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD98"/>
    <dbReference type="InParanoid" id="A0A1Y2BD98"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="387" mass="41489" checksum="84C55239DA2F3E06" modified="2017-08-30" version="1">MSVQPLPLPMYGDRPVVLLTNDDGPPSASSPNIFAFCKLLQERLGWIVKVVIPDCQKSWVGKAYAISDIITLSYFYPLGPDGLTGDITPTPRPLKEGETMEWILLAGTPASCTNIALHNLYPGQIDMVISGPNHGRNSSTAFALSSGTLGAALAGALSVPLPGPTPSELSLHVEHIPCIAVSYGVVARPVPPKALEYSHDVAVDVCDRLWRNWGYEGEPGPSRRRVQIYSINVPIVEEALEPQNRKVVWTTMWRNAYGQLFKTTKLDKAAYDPSDNAKQDPNRPAKAVPPRVSTTATAGPGALPTPDPASPAETGSSRQLKFHFAPTMGPLLFPPEEIVPEGTDAWAFAKGYVSVTPMRAEYAGLGAGGCGFGSEESGMVPGSEWKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDC8</accession>
    <name>A0A1Y2BDC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cell division cycle protein 91</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_521894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDC8"/>
    <dbReference type="FunCoup" id="A0A1Y2BDC8">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDC8"/>
    <dbReference type="InParanoid" id="A0A1Y2BDC8"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="427" mass="47645" checksum="5751080292722857" modified="2017-08-30" version="1">MVLQLKLHEQQQQWLTLAAGAVLRLALFALTSLPSKLQHRPELVSPLTTFRSLSEGVFLYKHDTNPYDGGVFHQSPIYLGLFSFFIPVTSPSFTALLWVFADLASAVFVSEIWLSRKPLGKEDHRKTLLVAWSLFNPYGLLTCLARSTSTLDNTLLLMAISRVASGKTYTAGILLGLSMHTSLYPVLLLPAFLMLSTATKQRAVQLIVFFSAIILPALASTSAFSTVWLRQTWGSILAVPDLTPNVGMWWYFFTEIFDHFRHFFLGVFQLHIVIYVAPICLRFRHDPLIAILVLAGVLGTWKSYPTLGDTAVWACLLGCFPEIVSNLRHPLFTLTVHLYTSILLPLLHSLWLLTGTGNANFFYAATMVYGLNASLAIVDVVGAAMRARVKDEVQKSVESVAEQDRHGRDAFWESQDWAIVQLTGPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDV1</accession>
    <name>A0A1Y2BDV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_523548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDV1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDV1"/>
    <dbReference type="InParanoid" id="A0A1Y2BDV1"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="256"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="579"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110224" checksum="A6AA3C85E4061CC1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDV9</accession>
    <name>A0A1Y2BDV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_523592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDV9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDV9"/>
    <dbReference type="InParanoid" id="A0A1Y2BDV9"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="935"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="935"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1069"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1096" mass="118545" checksum="FF506DE3337E9F3D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE17</accession>
    <name>A0A1Y2BE17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_587053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE17"/>
    <dbReference type="STRING" id="71784.A0A1Y2BE17"/>
    <dbReference type="InParanoid" id="A0A1Y2BE17"/>
    <dbReference type="OrthoDB" id="2576496at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="509" mass="57378" checksum="FFB8666F2D70A6C1" modified="2017-08-30" version="1">MTRVQPSSGRNTYPSRTYSTPSPSPDVYYPHSSQYRRYEPYARTQPPPRLFPTPPGHNGHQSSYAAKAYETNRPTGRYQPSRGAQRDAKWHARYGDRQHPILRSSPGVVAHARYPEIPIQTNTGMSNMERIRAEQRAAIDAARKAHLENVRKETEERKIRRIQLQVFVHARPTHCRWSACHAVMNSWALLERHLHHAHLHPQKTTSYGRVQCGWQGCQDTFFTREDCYRHCLIVHMAEFSGRCPFNCLFESPRFSDLLAHIGRRHPQATPDDFVPGLIHHRPPLPQSTELPKLPGTVILSEKDGVDHSVKAFKGGISARVRRMVARSCISGRRPRKEHFADRQGAKAAISAVIENSRRLSLAPPVHSAIEEGEDEADFAEPPSPFSVPHTARTDVDLIDVSTTAKEAADIAARQLQNDDSTLPTQVVDIDSESNTGSRPPSQTRILKIDTEMSETDSVTEITPVKTPVKTRGDRQRSRRGSEVGLLAEEGLKRSTRLRLRAERGFSTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE95</accession>
    <name>A0A1Y2BE95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_522211</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE95"/>
    <dbReference type="STRING" id="71784.A0A1Y2BE95"/>
    <dbReference type="InParanoid" id="A0A1Y2BE95"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="316"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="665"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="736"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY32870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="916" mass="100594" checksum="476FBDD1DEE6572D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEC3</accession>
    <name>A0A1Y2BEC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEC3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BEC3"/>
    <dbReference type="InParanoid" id="A0A1Y2BEC3"/>
    <dbReference type="OrthoDB" id="2592275at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="714" mass="77147" checksum="B5B1CFD494F36D48" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGT3</accession>
    <name>A0A1Y2BGT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_586218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGT3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGT3"/>
    <dbReference type="InParanoid" id="A0A1Y2BGT3"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="462" mass="50335" checksum="B9797C916D3FF0C5" modified="2017-08-30" version="1">MDWIAYSADHQSDAALEAELPWADSENNCSEDDWNCNGDAVGAAVLMGDDAVSGGSTRPIIDPEMLASMLRDCLLQPFLSTIPNPKDVTSDENTLPVTPPSCSLPQELELMVNPLCEEFFDPLWLPHETSPVKVRIPNDYLSSQHGGCDACGELGVSKVIRLIPCGHIICSLCFTTSLSAVSVVHGSSKCTACMEEVSSFRPFNNIRQAPRDKGHSDIQQSQSTASRSMAANDGNVVMRIDNVAWDITPAIVKAFLPRDSLVSSPVPIHILLDRFDGRTKDYMYIEVISQEAARKIMKTRQNTFMAGGALTGGRKRPVTISPVSHAELISELRPRSAVELNGLLSLCQAAVSTPPITNPALSEMTSFVAPNGVAHFVKSRHGPFYALMSILSKLRGKQSPAYWDVFHVASGAIAALANSISRYSTKTLHTTSLTEDPTDEDILERLADLFQFTFQLRPDRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH23</accession>
    <name>A0A1Y2BH23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH23"/>
    <dbReference type="InParanoid" id="A0A1Y2BH23"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012214859" description="DUF1748-domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8740" checksum="692C904D4626294B" modified="2017-08-30" version="1">MFGRLTHLAIDLIAISTILAGVKKATGFAPQTDHIKDTSIRHFLESYFSIGDTVFGMVCGYVVNSGYFRQDRRLGGGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH34</accession>
    <name>A0A1Y2BH34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_586293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH34"/>
    <dbReference type="InParanoid" id="A0A1Y2BH34"/>
    <dbReference type="OrthoDB" id="2573934at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="155" mass="16625" checksum="B878DEE18333877D" modified="2017-08-30" version="1">MPSLSAAAKMSETPTTSTSKSTTSTKTSSASPSSITPYSYATSDIVKVTVAAGVIVLVLSALVFFFKISSWIQYHRRLSRQRHLTTLLATEQRANVYEIAAWSDEPGTAPVRTGIGGGVGGSDRKSRKEIREEVRAFKRGGANAHAVHEWEGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIE4</accession>
    <name>A0A1Y2BIE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_556079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIE4"/>
    <dbReference type="InParanoid" id="A0A1Y2BIE4"/>
    <dbReference type="OrthoDB" id="2563592at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="140" mass="14834" checksum="B3953319B2AD5372" modified="2017-08-30" version="1">MLSPKSLTVPDFSAPPKVTRSFSISSSLSSGSGSSAYSGTSASSAYSRSADDMLDRLAALDSTATVHLWSAGNVRFNGRDLTIPSQDAAELIEAMKVDERFEVTDLVHLGGGEDWKVSFRRTTAVSLTTNGDKGERCPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIK9</accession>
    <name>A0A1Y2BIK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tubulin-tyrosine ligase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_513665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIK9"/>
    <dbReference type="FunCoup" id="A0A1Y2BIK9">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIK9"/>
    <dbReference type="InParanoid" id="A0A1Y2BIK9"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000133">
        <property type="entry name" value="Probable tubulin--tyrosine ligase C12B10.04"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="500" mass="56177" checksum="BB781590366E0624" modified="2017-08-30" version="1">MSGQSSSSPGRLTTFVSFPSPYTQSLLVSALVSTIPNLALSLAPYPEDDPPSLQWADYDLLSFDKPHANPSRYLISSYIYRKALIRKHQLHMTIAEYLAKIRHRGQHSVLEEGGVPKGWIVDIQFTDELDELLVDDLYELAEQLRENEEVSEDAKRWYILKPGFADRAQGIRMFSTEDELRAIFDEFEPPSDDEDEEESAQDSSEEDSPNRLASRIDELGVEDDDEGGTGVMTSQLRHFVIQEYMPRPMLFDIADASSGHKFHLRAYVLITGAYTVHVAHTMLALFSGSPYVPPRSSEDLDLLPHLTNTCLQTDAYGAPTPPAELVKTFWELEGLEALKNVGENNEVVGKIDKAWLERTFAKVGEVVAESVRAGAECGSFGLQFLPNAFEIFGVDLLLSFPESTSTSVSSRVPEPIVTLLEWNASPDFHQSGDRLRKELREMFKGAIRIAVLPFFGIRSDDEDVEIPGEKEAHEVEWEVGDERWGWRMVGKGEIRNFGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ53</accession>
    <name>A0A1Y2BJ53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_461978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ53"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ53"/>
    <dbReference type="OrthoDB" id="3338772at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="681" mass="78723" checksum="3E40204D7F353FA2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJF9</accession>
    <name>A0A1Y2BJF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_515462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJF9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJF9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJF9"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="287"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="578" mass="61816" checksum="2E594B56EC3312C1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJI7</accession>
    <name>A0A1Y2BJI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_490578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJI7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJI7"/>
    <dbReference type="InParanoid" id="A0A1Y2BJI7"/>
    <dbReference type="OrthoDB" id="2574383at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="290" mass="32552" checksum="B7BAEFABBBC4A2EA" modified="2017-08-30" version="1">MTPIGFIADFLGFLFLYNTGLKQLKSGLRNAHAESIKSLLTVFLIISTAQLIPSFLFDSSYHFGSMWSFFFPVLLFTRWSQTNKDATIASSICDTFFAQLSTIIHGFYPDAWKGDQGQSFGIIVGVVVILLFWVGYLGSTGSFLTIWFFLAISTINTIGEYVPDQTTQLEYYRTQQTIWHNLLAIWMFRFLISTLESISIPGLVSLLDVVLHHLPSYFLWITIFLFAMLLTKKTVDDTTKVADTWYARWLLGTRKSAPVSSQSTTTAAPVAQTKASSSHGSSSRSHSKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJJ0</accession>
    <name>A0A1Y2BJJ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_515699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJJ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BJJ0"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012960188" evidence="2">
        <location>
            <begin position="18"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="434"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="708" mass="74586" checksum="467F9559998AF371" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJJ3</accession>
    <name>A0A1Y2BJJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEMO1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_515739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJJ3"/>
    <dbReference type="FunCoup" id="A0A1Y2BJJ3">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJJ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJJ3"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="341" mass="37821" checksum="1F784020A96FFDA4" modified="2017-08-30" version="1">MPGTREPTHAGSWYTSNGSQLQRELSSNLSRVTPIPDLAYNPPIQNAKALIAPHAGYSYSGPAAAWAYASIPTNKIKRVFLLGPSHHAYIPGIALSSFDSYGTPLGDIPLDLDVINKLRRTGLFLEMKPSVDEDEHSLEMHLPYIRQVFAGRDDLQLVPLLVGHVDSKSASKIHQVLAEFWADEETFFIVSTDFCHWGTRFSHTPYYPHAPHPPHPVPPVPQIAQPAALDPPDLIKRFSKADPDTPIWKSIQYMDHEGMDLLRDPAGEGSVEKWLAYLDHTKNTICGRNPITILLGLVSHIHGQEAAKPEIVFVRYEQSSRCENGKDSSVSYVSGVLRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJP6</accession>
    <name>A0A1Y2BJP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_462412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJP6"/>
    <dbReference type="FunCoup" id="A0A1Y2BJP6">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJP6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJP6"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="9">
        <location>
            <begin position="323"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="9">
        <location>
            <begin position="458"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="538" mass="59423" checksum="534CF4C551F16DD3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJT0</accession>
    <name>A0A1Y2BJT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_144265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJT0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJT0"/>
    <dbReference type="InParanoid" id="A0A1Y2BJT0"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="196"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="393" mass="42794" checksum="FE1777D0E8243EF2" modified="2017-08-30" version="1">MVQMCDKPANSGSLRVYGHEFLAQRCLVQLSLGHPFSRTSSKPPPVKLYSRSGQDSLHLWSSLKLVMTSKLDITAVPHSVILPLADEREVFSFQVQSLERFTLELSLYPTFGSKVIGRAVILPATFLDIRYHKSLVAPLLDHQLKTIGEVAFEVSCIKPFEGAQLEIGGRVETYWKSKVTPSAPTQDHAHPFQTHRPLSVSTSSPALRPPAIPPSSQPRESALVTASSLSGDYVHVVVQVTKDGHPVVYPDWHLPIPGFEIGVTGVTLAQFQALAASTSRPLVTPETSSPSEWSPVISNSLVSLEELLAVLPSDIGINLQLRYARSFDAQALSVGRSGEINEFVDSVLHVIYEAGKATQGRKVIFSSFDPTVCTALNWKQPNCKSADSSASTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKL8</accession>
    <name>A0A1Y2BKL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_461596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKL8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKL8"/>
    <dbReference type="InParanoid" id="A0A1Y2BKL8"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="484" mass="52303" checksum="632DF93DAED8CCB1" modified="2017-08-30" version="1">MTIKVDDIAATLPPVGAEGTYKSDSNGEVRSEAAQKRNIDLPLPEGQCLSLWLQTVRNNPLLDHRTTEELPSQAEVVIIGSGITGSLTALSLLQSANPPSSIVVVEARELCSGATGRNAGHCKPDQWRGFTKYKQAFGAEQSLKALVAYVRKHNVDCDLWVGKTVCASSLDVAMTREIAEVSAKNFADYKAAGGKVDHIEVITEPAAAEKRSRLKGAQAVYAWDASTLHPWKLVANVIQKALDLGLNLQTWTPVSAVTGSEGKWEIHTDRGVITTPIVVHATNAYAGHLLPETKGIIRPTPHMCNKVLPPASFAGSKALQNSYAVMFPEGLYSINPRRAGDGIVLFGGSAPNQKFLNEYVNSDPERKTNDSLINFEPVTDAVRKLGTEHFQWDPVPGQSKGNAVRYDYAWSGIIGRSADGVPYIGKVPGKPGQWMCAGHNGHGMARIFTCAPALAKMIQGASWSETGLPECFEVTKERLDRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKZ2</accession>
    <name>A0A1Y2BKZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_509764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKZ2"/>
    <dbReference type="InParanoid" id="A0A1Y2BKZ2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="223" mass="23975" checksum="F40492463088C027" modified="2017-08-30" version="1">MAKKSTQKPVQAKPSQTPSSSIDDIFAKPLVKSKSQSIPVAGPSTSTSTSTTSKTNSLPSSSHTNSTGDSKTRELKKKKKKSSIKSFDPDSEPTPAQQPSQSLVKQTKVVETILDPSSLPPPSTVSFVGDKGKSIDGVGVRNGGGGGGGGKKRSRKDKDDEEQDALFADSRGEGPSKSFVLWSIPNNPWSWTLEKTQRSYLPCSIYIAYQFTIIQDDVQKRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL42</accession>
    <name>A0A1Y2BL42_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_508741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL42"/>
    <dbReference type="STRING" id="71784.A0A1Y2BL42"/>
    <dbReference type="InParanoid" id="A0A1Y2BL42"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="736" mass="81716" checksum="E97433C2AB3B6B1F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL96</accession>
    <name>A0A1Y2BL96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_461665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL96"/>
    <dbReference type="FunCoup" id="A0A1Y2BL96">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL96"/>
    <dbReference type="InParanoid" id="A0A1Y2BL96"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000099">
        <property type="entry name" value="nuclear transcription factor Y subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="148" mass="16128" checksum="59B96B6E6A730D54" modified="2017-08-30" version="1">MSFSPPPTSTTIGQTPNSLPNLAPVGTSGKPLSAPPTAPDLPFTDAQVEEFREQDRWLPIANVARIMKTALPGSAKVSKEAKECVQECVSEFISFITSEAAEKCLNEKRKTINGEDILTSMRALGFDNYEGVLKVYLAKFREASHPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLL7</accession>
    <name>A0A1Y2BLL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/calcium exchanger protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_511392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLL7"/>
    <dbReference type="FunCoup" id="A0A1Y2BLL7">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLL7"/>
    <dbReference type="InParanoid" id="A0A1Y2BLL7"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012756517" evidence="9">
        <location>
            <begin position="27"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="85"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="750"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="908" mass="98400" checksum="45C008B092299A08" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLN1</accession>
    <name>A0A1Y2BLN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">And other transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_555635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLN1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLN1"/>
    <dbReference type="InParanoid" id="A0A1Y2BLN1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="566" mass="61716" checksum="218A6FA8EFEBBB82" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLU3</accession>
    <name>A0A1Y2BLU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_511830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLU3"/>
    <dbReference type="FunCoup" id="A0A1Y2BLU3">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLU3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLU3"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="767"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="6"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112388" checksum="E6DD135C454C18EC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLY7</accession>
    <name>A0A1Y2BLY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_555729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLY7"/>
    <dbReference type="InParanoid" id="A0A1Y2BLY7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="338" mass="37992" checksum="AEB687E26F86281B" modified="2017-08-30" version="1">MSAAIQPRYQADSLFKDSLPLAFRRDTTIRHEPASVHGDSLHRRNEIEREAENSWRLRNGGGLHAPLNDTTSAGNRQHDGADSSLTRAVNNPVAFHILASATTDDVDEAERTANEARNVEIWAKIKAGLYYVWSWHVMPYDVHPNRWNPTLFWCLAFASLVPLLPALTFHCIGRINKEKINTLLPKLEQAIQLIQSDPSSAEATEIINRHSRLLRTVRISEVGGLWTAIIQLPVLVVTYHFLGVFSVPLSYLWLYLTCLSRGERHSQPRVVIANCLNWIAGECDKCGVYIVGGIRNIHHEDSSIRNTMNIVIGLFFFSRATMIAKCWSGDQPPSPAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADH7</accession>
    <name>A0A1Y2ADH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_82834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000130">
        <property type="protein sequence ID" value="ORY20603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADH7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADH7"/>
    <dbReference type="InParanoid" id="A0A1Y2ADH7"/>
    <dbReference type="OrthoDB" id="2131339at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="POSSIBLE DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26217" checksum="1A141B4CEB7AD0BC" modified="2017-08-30" version="1">MVKDSAEVVKEFNEIVNMTADELDAFLKTEASTSTGWSKDDGSGESIGHESGRKIVDILHRNPDKDPSKYTEQDKEHMRKVVSYCKRHLAQEEHMKQEKTPEELEKTKSTRSLKNWGHDPMKTIKSKPASKGKPVSKAKPASKGKPVSKGKPISEGKPVSKAKPSSKGKPVSKKAANHDKADKVDEVEKDDKVELGKKRQSEPASKTDKPASKKTKTQNPPSEATRKPPSRGAKAQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADU1</accession>
    <name>A0A1Y2ADU1_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_555354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000135">
        <property type="protein sequence ID" value="ORY20450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADU1"/>
    <dbReference type="InParanoid" id="A0A1Y2ADU1"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="645"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="866"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
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            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="189"/>
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        </location>
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            <begin position="267"/>
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    </feature>
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        </location>
    </feature>
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            <end position="438"/>
        </location>
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        </location>
    </feature>
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            <begin position="517"/>
            <end position="527"/>
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            <begin position="577"/>
            <end position="589"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY20450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="957" mass="106528" checksum="D49297876EE3F3EE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEU4</accession>
    <name>A0A1Y2AEU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromatin remodelling complex Rsc7/Swp82 subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_508481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="483" mass="53515" checksum="B162B53AD82E4027" modified="2017-08-30" version="1">MDSIITIKGVDYTVGDDELIIDDDPKGDTKIDALGNLLGGREYKLTTFTSPTRRSPTKVYALTIDAARACGYTDSLAFLRRCPQLLKLACNSDERHMLIEIGRVTGNLRNRMVTMVAMRNVYKLMGARVVKNGKWVTDDYYEEKSLAECVENGFTPGAVAHEDEILANALTALNPQGRPPNNTATQEITRQAANLTSFYTLGGPTTTFAGNGADPFSEHGHGHKRARLRNVGVTEEDWILRTAEESRRIDAQLKAYRAERLVELNGPDLNGWVWTAERSTEKMEGRDDLSLPKVERRRSALSHEVVLQGDEKEPEVDVDVSMHLAQEVENGDGDGKAEAGKIVVQTPEETRHASAAFNWGLGSWAPGLVKAAYEPHTNMPHVPNYTQPSTANSTRLSHFPILAAQADTQHKNFVMSSVTGRAARGLASVEYVLETSEDRMEIKDDKGLFEFTSGGPEVLERMVRDAEEWEKREREKKAAVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFP7</accession>
    <name>A0A1Y2AFP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_508549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Naematelia</taxon>
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    </organism>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000125">
        <property type="protein sequence ID" value="ORY20785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFP7"/>
    <dbReference type="InParanoid" id="A0A1Y2AFP7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY20785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="216" mass="24180" checksum="BC9035F740DBC4AB" modified="2017-08-30" version="1">MTQLSETPDDECSVVFLPPRPVCPSADRNDPSVSSAAEEIMKKGTDWYDAASRAIPESEVNSQIMRDHRDQFMEYLDEESVLKNDENLTKMVDTAYLRATKKVYQETHLTGSKRSHQKHFYSQNKSRTDGLRTWAHKNRFSNSSVSSTIGRFGTGPVWSQNLAPSPSTCFGFHDDATNVSNAPLTGEMNHEKEEWDFCEGATCGDITGGAELSWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGM3</accession>
    <name>A0A1Y2AGM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_553874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000113">
        <property type="protein sequence ID" value="ORY21337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGM3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGM3"/>
    <dbReference type="InParanoid" id="A0A1Y2AGM3"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="305"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="683" mass="77041" checksum="78DC5D121A8F1A95" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGV9</accession>
    <name>A0A1Y2AGV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_591561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGV9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGV9"/>
    <dbReference type="InParanoid" id="A0A1Y2AGV9"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39090" checksum="5B4C85DCB2065D08" modified="2017-08-30" version="1">MAPRNIKPGVYAPVLTFFKAGSQDIDLETFKKHVVYMGERGVGPVVCGSMGEAPMLSEDERLQLVRSARSALDNAGLELPLIVGTGLSSTRGTIDLSRKVAAAGADIVIVIPSGYYASLMTRAALKKFFLEVSQASPIPVLTYNFPNAAGGVDMDSELLEEIARDCPNVCGAKLTCSQIGKVTRLAGVVSQPAFAELYPRSWRRNDDQPPFVVLGGFADFLLPSLIAQAHGAIAGMGNFAPRTLRRLYDVAQEALKTGDIGLLGDAQKLQAMVSQADFPTSWVHIPGAKRLLEDLRGYGGLPREPLRPVDEEAYQKMMRNPAVIQLLELEKSLEAGGEEDALSEQIVPSNLVSHLQTTIRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGW6</accession>
    <name>A0A1Y2AGW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_591588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000111">
        <property type="protein sequence ID" value="ORY21427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGW6"/>
    <dbReference type="InParanoid" id="A0A1Y2AGW6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="314" mass="35375" checksum="619AE08C955D8866" modified="2017-08-30" version="1">MTILCFKIRILGSSVFTYAFSYMLRREGRAADEVMEARRTEVSSRETEVSSREVDVSREVEAIRLKTKRDVAVMSHLSAMFPTSRTFGTLGELLIEVDRICQNGYFPDLVQKFRGQKGFYPDFLHTKQIHETIKTIVHIADAEWRKYTLDDVLTEADLYYTGCVPFLEHSLDDLTTLLQYRTASQITFKDIFDHPDFAIDPAATDPRVIATHFFKWMEVVRNWRRNNSQVLASTAIATATEALATAIATMTATETEKETATGTGTGTEISTAATDILTTRSLMSVPATETAIVTEGPTRRSLMSRLSPFKSRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH41</accession>
    <name>A0A1Y2AH41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Exosome complex component RRP4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exosome component 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_552650</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC4 and EXOSC7. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with GTPBP1. Interacts with ZFP36L1 (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000102">
        <property type="protein sequence ID" value="ORY21899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH41"/>
    <dbReference type="FunCoup" id="A0A1Y2AH41">
        <property type="interactions" value="720"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AH41"/>
    <dbReference type="InParanoid" id="A0A1Y2AH41"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000022">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="15">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="17">
        <location>
            <begin position="104"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="16">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY21899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="339" mass="37061" checksum="7B4D4739C5F2BE76" modified="2017-08-30" version="1">MFKITRSAPTLSQSFLEDESVPSVHRRHPDELSAMDIDDNDNDLGIGPSSLRKDIVSAGEVITSSKEFMRGHGTYVEDDQVISSVTGTIEKVNKLISVKALKSRYVPEVGDLVIGRIVEVQPQRWKVDTNARQDAVLMLSSVNLPGGVQRRKMESDALKMRDFLAEGDLLVAEVQAFFADGAMSLHTRSLKYGKLRNGQLLTLPPRLIRRLKSHFHHLPPPCGPTGVDIILGLNGFVWVSAGTSESQREGGEGFDAEGVYSNVNDDISPEGRRAIAEVANLIEVFAAYDVPLSDTLIADGYAWITQQRKSRPSSGAIRGGEAERMVFEVTGLDIISTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI35</accession>
    <name>A0A1Y2AI35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_552219</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000098">
        <property type="protein sequence ID" value="ORY22132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI35"/>
    <dbReference type="STRING" id="71784.A0A1Y2AI35"/>
    <dbReference type="InParanoid" id="A0A1Y2AI35"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="15">
        <location>
            <begin position="46"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="14">
        <location>
            <begin position="163"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="13">
        <location>
            <begin position="270"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="377"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="404"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="406"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY22132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="432" mass="47010" checksum="D60C897D550436B3" modified="2017-08-30" version="1">MKLRSVGCSLGAVLRSSHFSLYRVGISPTIQRRAASSYNSAVAGLTSDQEEFRQVVSNFAEKELAPRAAEIDRENEMPPDMFLKLGEMGLLGVTVPEDQGGLGLGYLEHTIAMEELSRASASVALSYGAHSNLMVNQLTRWGTESQRKKYLPKLLTGEHIGSLAMSEPNAGSDVVSMRTRAEKKGDSWILNGSKCWITNAPLSSTFLIYARTSVDGQPSKGLTAFLVERTWKGFEVGPHLDKFGMRGSPTAELFFDNVEIPEENVLGGVGKGAKVLMSGLDLERLVLSGGPLGIMQAALDLTLDYTHDREQFGRKIGTFQLMQGKLADMYTKLSASRAYVYAVARACDSGNISRQDCAGAILYASDRAVEVAMEAQQCLGGNGYINEYPAGRLLRDSRLYTVGAGTQEIRRMLIGRGFNEMYDEARGKGVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI50</accession>
    <name>A0A1Y2AI50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_48481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000101">
        <property type="protein sequence ID" value="ORY21950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI50"/>
    <dbReference type="InParanoid" id="A0A1Y2AI50"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="387" mass="43179" checksum="9BB1B22612ED2044" modified="2017-08-30" version="1">MVRASKRRLHRESSDEQQAADSVPTSLPTPAPMQKRPSSIAPSGMSEPLGRLTMLSNVATRSSHPLNSHGQEQLYLRQTFILVPETFQPGDLKLYEELIKREGGLTITTSAFNFQATSTAMCAPSASSPRPSTTFLLLPTPEHASTAFASQFPSSSDLLYSFLSLLGIPDTIPSSIEVRSTKWLLSTICSTRTTETPDTAFFDDHHPPLGPRDVKRYMALTKYYRENKDEFRNLSGFYQRADQALKDFGPDVSRFLAPVTHMREPGVLAIFFRCNGPCLRSLGLLCLPSVYHLFLHALGAYSISLSVLVCIPPFLLCEVTSIAQSTYLMLLRHFRVSSDLTISPQFWLHFCPVLKYSHRPSIVPALAHRSQADRSRHHCQSPLTPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIQ7</accession>
    <name>A0A1Y2AIQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_385423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIQ7"/>
    <dbReference type="InParanoid" id="A0A1Y2AIQ7"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="340" mass="37985" checksum="1EC3C401219E8990" modified="2017-08-30" version="1">MQTHPLLEEQLTVPLRHRLLKDSVPSRLLLLLLSIRLDNSNRLDLVVKVKVIVVLLDNPPTKLPIPHVRLLKMFRITLTRQLNLLVSRLIRRQTRLARLLRPLGRLLRTQLKRLATLLRTQSSPLVRPPIKPPTLPNQLRRTSLIPLDRLLKTSQSLPDRPPPASPNPLDRLPPTLPSLLDRPLKQQSPVSESGSTACLASSRTLAIFQLCRTPKAQLRNKSDNYALLLVDPLRSLTSRNAPVLIESSSSSEESYSLLTLLPPSILAVDVLESPGSNVSNDDDKFKGLLAYFVVLGFIQFLESLAAGVLAKTIRESTCLYSLDVPHPSLFLTLVYGTFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJK4</accession>
    <name>A0A1Y2AJK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_551682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJK4"/>
    <dbReference type="FunCoup" id="A0A1Y2AJK4">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJK4"/>
    <dbReference type="InParanoid" id="A0A1Y2AJK4"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY22377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="234" mass="26319" checksum="90E175A9B4213FCF" modified="2017-08-30" version="1">MASHLANIFGTEQDRVNCSFYLKIGACRHGDRCSRKHIKPQFSQTILLPNVYNNPAHTPEGQLMTPQELQANFDRFYEDFFIELCEFGHVLEMHVCDNVGDHLSGNVYARYEWEAEATNAVNHLNDRWYAMRPLHAELSPVSDFRESCCRQNELGECSREGFCNFMHLCHPTPSLVKSLQASQRVTRRKKAANGGNLPQGDLGWTPSAAKNDEGAAAWQPRNGGGGSGDSYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK08</accession>
    <name>A0A1Y2AK08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_550814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000087">
        <property type="protein sequence ID" value="ORY22846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK08"/>
    <dbReference type="STRING" id="71784.A0A1Y2AK08"/>
    <dbReference type="InParanoid" id="A0A1Y2AK08"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY22846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="274" mass="29063" checksum="477F7477A7D2A893" modified="2017-08-30" version="1">MSEPTIAQRVNHIRKAWHEGRPAYGIITKAPGASLVRTLAGLSRFGLDFLVTDGEHGNYDEASQHDAFHAIASLGVSPIARVAGMGSEKWGIRVALDAGAHGVMVPLLESKEQAEDVVHRAKYPPQGGRTSGGSFNLQAFHLEPHGRTLTQEEYFKAANEATLIIAIIETKHGLENIDEIVQVKGLDAIFIGQYDLALSLGSLPQSSPIVQDGVKKIFASAKAAGVPVIAWSPGDEAKAAAAQGYEGLIVGLDMSILTRGGAEDLAKAGATKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKC4</accession>
    <name>A0A1Y2AKC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TLC domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_550832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKC4"/>
    <dbReference type="FunCoup" id="A0A1Y2AKC4">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKC4"/>
    <dbReference type="InParanoid" id="A0A1Y2AKC4"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="112"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY22750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="381" mass="43565" checksum="39D57FD1E2B8B651" modified="2017-08-30" version="1">MQRNMTQLPTLTHLQSRLPTSLLQFVSLQYPVPPTTSSRLASIFSSSHSSSLSSPPPTLYSNGPRDVYFVFSCAVAFTVLREVIIRGIVTPSARYWLVKDRASKREKRKLHHIITRFAEQSWSFFYCSIFWSIGVTIVRRVPGFTTPEQLWGTYPVLYLPALTKFYYLAQLGWWFHQIFVIHTEKPRSDHWQMLGHHILTITLIVSSYRANFTRVGTLIHVLMDFCDIVLPLAKMLRYLSLSTACDATFVLFLVSWLFSRQVGLFLVIKTSYFDAPKFIPFEWNPSAGRYLTHTTYRIFIAMQVVLYCLATAWFYLACMVAVRVVRGLGADDSRSDAEDEGIDGEESPLEDVPTTTTSGHHIIPSETPTPNGQDGELRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKK0</accession>
    <name>A0A1Y2AKK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_550047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKK0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKK0"/>
    <dbReference type="InParanoid" id="A0A1Y2AKK0"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="151"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY23036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="387" mass="43131" checksum="DC7809F888233058" modified="2017-08-30" version="1">MRLVRPPFPLGWSSIPLSPLDLTIANTLPVGQSFLWHRRLLEDPGQPSEEFSRAVDDPPRVVCLRQSATTLYYTAIHPTDQAAERDLQSNSTKRWLSDYFQLDRYPDLSQLYADWRNRDPGLFGKVELDGRATGVRVLRQDPWECLVAFITSTNNHIPRITSLMYKLCQHLSPNLLTLEETDGSTITYHLFPRPHSFPSHCESLLREMGFGYRAAFIESSISTLRQTFGDAPGDVDAGLEALRGASIDDVRQKIIGLKGVGRKVADCVMLMCLDQPSLIPIDTHVGAIAARHPAFPSRLRNKPMSKQVYEEIQAFLSEQWGPMGGWCQAVMFAADLPISTTTPRKAASLPVTPRKIVQAVSPSSTLRSLDIATRRRLVSSAPVALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM85</accession>
    <name>A0A1Y2AM85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_344763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM85"/>
    <dbReference type="STRING" id="71784.A0A1Y2AM85"/>
    <dbReference type="InParanoid" id="A0A1Y2AM85"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="451" mass="49023" checksum="FC2F3A9C197E8CCB" modified="2017-08-30" version="1">MVNKVNLLSWLYQEFGLESVYRAGPNAWLIILSRSSRMFAYGAASIIIALLFSALEFSDFRIGLFMTLTLVGDVILTLLLTLVADKVGRRRTLLLGSFLMVLSGVIFMVSDSYWILVIAAVVGVVSATGSDFGPFRAIEESIVSQLTTTETRSNVLTWYVTSASLGSAIGTEASGRVVDALKAREGWTIVDAYHGIFGVYVVMGLLNMACVGLMTERTEADHGEKQSDVVLEEVEPLTLEGRLSVDDSTNAVPPKQSTFAQISKKTRSVMFKLWPLLIVDSLADGMVGYSLTTYYMERRFHIATSTLGDITSISYFLSAGSTIFSGPLANRLGLINTMVFTHLPSSAAVLLFPLAPNLALTIVLFFIRTGLNNMDQAPRAAFIAAAVQPSERTAVMGITSMLRTLAATTGPSVTGWLAESDQFWIAFVLAGSLRIAYDCGLWALFVNMKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP71</accession>
    <name>A0A1Y2AP71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl CoA binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_547309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000069">
        <property type="protein sequence ID" value="ORY24296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP71"/>
    <dbReference type="STRING" id="71784.A0A1Y2AP71"/>
    <dbReference type="InParanoid" id="A0A1Y2AP71"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY24296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="442" mass="48911" checksum="8223C18268E38BA2" modified="2017-08-30" version="1">MASQVIDAQFHRAVDIVQSLPKAGPVQTSYEDKLRLYALYKQATEGDISITRPGLLDMLGRAKWDSWNKQKGVKKVEAKRLYVASLLKILRRFADRESAKKAIEELEGFSEAEPSEIRHRPASPASSSSSYHSSQASPPLSPPSPPRYVLYPPPDPSLPPPDVAPDIIPPSALTHSHRSLLSLTAMAPPDITPSEPQSFAGTPALGPAQGSRTHSLIGGRGGGEAKTARKDSVHSFRQSRMPQGHSALGFVPEQQPKASSSRPYSPQLPQARDYATPEISGSSPYLGISQGMPLYPRPGSASTFSQQPLNVPHTLQQIQTSLAALHERLSSLERSQAMLLRRDDRRKRWFWSSADELDEMEEDVERERWPTTRTTTRIRQRKSLSVRAIWWLIAAVRRATIDAGVGLLILLAGIFIMSGGWRRTRATLARVRVTVRQFISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APD3</accession>
    <name>A0A1Y2APD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_546624</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APD3"/>
    <dbReference type="InParanoid" id="A0A1Y2APD3"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="592" mass="65617" checksum="3274DF8008D02237" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APS1</accession>
    <name>A0A1Y2APS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_321799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APS1"/>
    <dbReference type="STRING" id="71784.A0A1Y2APS1"/>
    <dbReference type="InParanoid" id="A0A1Y2APS1"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF11">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="56"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="158"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY24474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="392" mass="43605" checksum="0E98106217CCBB48" modified="2017-08-30" version="1">MSDTTLPKMHRVGVIMNGVTGRMGTNQHLIRSIVAIRKEGGVKCADGEIIMPEPVLIGRNIARLHELAKLAGLDTSVVTTDLDSALADSRNVIYFDAQTTGRRSDAVKKAIAAGKHVYCEKPTAVNTADAYDLYEVAKTAGVKHGVVQDKLWLPGLVKLQTLIHSGFFGEILSVKGDFGYWVFTGLTPVAPQRPSWNYRKEDDGGMIVDMLCHWRYIIHNLFGPIKALSCFGATHVKKRVDESGTVYNCTADDAAYATFELENGVIVQFNSSWATRVRRDDLLTIQVDGMKGSAVASLRDCVVQHESATPRPTWNPDVPSSIDHLAAWNRVPDWQTFDNAFKIQWEMFLRHVVKDEPYTYDLLEGAKGVQLTELGLESWEKRCWVNVPELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ36</accession>
    <name>A0A1Y2AQ36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_546611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ36"/>
    <dbReference type="FunCoup" id="A0A1Y2AQ36">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQ36"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ36"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="105" mass="10797" checksum="74828EC16D2AE7C6" modified="2017-08-30" version="1">MSDIKRPSSPGSPSPAPGGASSAFQVARPPGANAIRRRAPSTPRPSSTRAAGAGGSSNTMLKLYTDSGEAGLKVDPFVVIVLSLSFIASIFFLHIAAKIVRAFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQG8</accession>
    <name>A0A1Y2AQG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_334238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000070">
        <property type="protein sequence ID" value="ORY24195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQG8"/>
    <dbReference type="InParanoid" id="A0A1Y2AQG8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="102" mass="11624" checksum="D5B9034DCCD5266A" modified="2017-08-30" version="1">MPLSQELVPGLMSARNNRKKAMLFQLSIPILLVWRLSGRCNMAYVSPETSKIISPTSNGYGVFVMIPGWWPALIVPRHLKFRAFGDEITTRPKGKTQRRVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR82</accession>
    <name>A0A1Y2AR82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_600273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR82"/>
    <dbReference type="InParanoid" id="A0A1Y2AR82"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="237" mass="24355" checksum="E13205B765F8CCA1" modified="2017-08-30" version="1">MSPTHSDDSDSDQSAATATQLRLRAGSTHSASSSISLSSGSASRFRHSASRSHSPHLPATENSLSDGPIPHTFPPSTVSTHDTAAGSRRTGSAPVASTAKQRFLLSALSGAAFAALLPVVVLGTKGSISASIQTAILTALGTMSARITEESIHVNMSATGTTHRLRGSDWDIQRDVWEKISVYATAAAVAYSNYRIVLDDNGSLTTAISAGAVSPCGIIMANALIDLLGRGVPADVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR90</accession>
    <name>A0A1Y2AR90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase catalytic core-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_581192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR90"/>
    <dbReference type="STRING" id="71784.A0A1Y2AR90"/>
    <dbReference type="InParanoid" id="A0A1Y2AR90"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013028168" evidence="2">
        <location>
            <begin position="24"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="148"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="385" mass="42222" checksum="AE393D408E79BEFC" modified="2017-08-30" version="1">MRVSTDRLLSLLPTLALVGLALTAVEDVPSAIAHNRRHPDHPRHLVQRQNLAVNVGAQEKKRGEVRRNSDGSQCRVKSSASSAFSSSITSSSKAAPFSTSTTEASKSTESAHSDTTSESATTPTSFVNADHKFGLAWPNGDYTSPGDPGYIGNYIGKRASSYYTWSASNVKSADKLGLAFMPMLWCGDKQSDFQAQQKNWPKTIKHALFFNEPNQDGQCNTAAGDAVSYWMNDFVPLRSRGIKLGSAATTSAPSGLSWVLDMIQDCENDGNSKADCTPDFAAIHWYDVSIDGFQAYVKNFHEKTGLDIMITEYACQNFNGGAQCSYDQTWQLHTTMAEWFDQQDYVIGYHPFGVMKNMQGVNQDNALMNTDGSITQLGNYVCSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARI9</accession>
    <name>A0A1Y2ARI9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PPPDE putative peptidase domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_545015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000060">
        <property type="protein sequence ID" value="ORY25189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARI9"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARI9"/>
    <dbReference type="InParanoid" id="A0A1Y2ARI9"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="7">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="153"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="6">
        <location>
            <begin position="333"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="620" mass="66642" checksum="6CB5BCE94093D3B9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARQ9</accession>
    <name>A0A1Y2ARQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome C oxidase copper chaperone-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_544643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARQ9"/>
    <dbReference type="FunCoup" id="A0A1Y2ARQ9">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARQ9"/>
    <dbReference type="InParanoid" id="A0A1Y2ARQ9"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000005">
        <property type="entry name" value="Cytochrome c oxidase assembly protein subunit 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="91" mass="9603" checksum="5CBCDAF69A5D0D65" modified="2017-08-30" version="1">MVSVLGFGSSSSSSSSVSSRSSSPDVALAPSAAKEVNPLNPQGLKPCCACPETKSKRDDCFLKFPAEEATDQCKQLVQAHQACMRSYGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARS7</accession>
    <name>A0A1Y2ARS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_293013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARS7"/>
    <dbReference type="InParanoid" id="A0A1Y2ARS7"/>
    <dbReference type="OrthoDB" id="2595963at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="93" mass="9915" checksum="6DE806E9B6A12850" modified="2017-08-30" version="1">MSAPLQQANTNTQPAKGLPSMLQKKGLLGAAGRGKMNNSIVSPTDNVLSPCSAKLSGAKQRHFQKYVVLPAHIPTLQSTIQIFNHSIHPTIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARU8</accession>
    <name>A0A1Y2ARU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_486174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000065">
        <property type="protein sequence ID" value="ORY24685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARU8"/>
    <dbReference type="FunCoup" id="A0A1Y2ARU8">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2ARU8"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
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    </dbReference>
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    </dbReference>
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            <begin position="66"/>
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        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
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            <end position="194"/>
        </location>
    </feature>
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    </feature>
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            <end position="329"/>
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    </feature>
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            <end position="402"/>
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    </feature>
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            <end position="456"/>
        </location>
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            <end position="484"/>
        </location>
    </feature>
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        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
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            <end position="601"/>
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    </feature>
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        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
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        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY24685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="802" mass="89519" checksum="DE7FE9F56CC31A5A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUI5</accession>
    <name>A0A1Y2AUI5_9TREE</name>
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        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_541526</name>
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        <name type="scientific">Naematelia encephala</name>
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            <taxon>Tremellomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
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    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="1072"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY26231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119917" checksum="7DFCD5B02CBA93B6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUJ7</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BCR39DRAFT_470528</name>
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    </organism>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
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                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="29"/>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY26229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y2AUS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_566124</name>
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        <lineage>
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            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUS1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUS1"/>
    <dbReference type="InParanoid" id="A0A1Y2AUS1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="53"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="342" mass="38000" checksum="E4CDDF13BD5E5AAE" modified="2017-08-30" version="1">MLIRTDPLYPSYLPTRPEGYTSNIDVPFFEADERALRADPALPELDNGSTQLTNITPRVGTEIRGIQISSLSKDGLDQLALLAAQRGVLVFRNQDFADIGPNRQRDIVRHYGPLHLHPTMGYPEGTGPEFHVVYADEKVGSIRDLLGPHTSYDLWHVDQTFTPNTPGPTFFWVLETPANGGGDTAFTNLAAAYEALSPAFRETLLGLDLYHTSASVGEIGRIGTERALKEAVNTIHPLVIEHPVTRKPVLFVNPTIAQRVVGFKPEESAHLLNFLHSHIKSLDFSCRVRWEPGTVVVWDQRTVAHSAVPDFEEGARRHMVRIIPYGAKPRAARDSIAQVHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV54</accession>
    <name>A0A1Y2AV54_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_542807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV54"/>
    <dbReference type="InParanoid" id="A0A1Y2AV54"/>
    <dbReference type="OrthoDB" id="2585251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="568" mass="62492" checksum="39E30706E43AAA1E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVA0</accession>
    <name>A0A1Y2AVA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_542997</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVA0"/>
    <dbReference type="FunCoup" id="A0A1Y2AVA0">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVA0"/>
    <dbReference type="InParanoid" id="A0A1Y2AVA0"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="35"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY25845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="712" mass="78426" checksum="A87EA67D99E45104" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVQ5</accession>
    <name>A0A1Y2AVQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_258354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVQ5"/>
    <dbReference type="FunCoup" id="A0A1Y2AVQ5">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVQ5"/>
    <dbReference type="InParanoid" id="A0A1Y2AVQ5"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="699" mass="77863" checksum="38A29B54942DB954" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWR6</accession>
    <name>A0A1Y2AWR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_251529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWR6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWR6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="131" mass="13234" checksum="78A7BD6774A2794D" modified="2017-08-30" version="1">MYSWNKSGFTVQDMYRYYALPFFCSFIAAILAFLSSRLLANSFSFSSLDICAKLGAGVAEGEGDDGLSSTSPQVSNVAAGVCTGVAVFGGIVAGTAADILGAGVGLGGLGCTVLVVVVVVVVPFGFEVGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWU6</accession>
    <name>A0A1Y2AWU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_539595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWU6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWU6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWU6"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="75" mass="8599" checksum="02D620A961D85761" modified="2017-08-30" version="1">MRPTAARPFINALVNRPNLVRDKQIALQNDPAPTYLKGRGKYYYRGFLVMLACSLGWSQFTLIQYVRGKAKKHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWX2</accession>
    <name>A0A1Y2AWX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="10">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_539060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWX2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWX2"/>
    <dbReference type="InParanoid" id="A0A1Y2AWX2"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18015">
        <property type="entry name" value="DEXHc_RecQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001544">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="163"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="379"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="726"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY27061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="829" mass="91481" checksum="D7F26A178C234FDF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWZ8</accession>
    <name>A0A1Y2AWZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannosyltransferase putative-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_560191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWZ8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWZ8"/>
    <dbReference type="InParanoid" id="A0A1Y2AWZ8"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY27091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="688" mass="78530" checksum="80C147EA3BBC25F4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX90</accession>
    <name>A0A1Y2AX90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_257183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX90"/>
    <dbReference type="InParanoid" id="A0A1Y2AX90"/>
    <dbReference type="OrthoDB" id="2588950at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="343" mass="38000" checksum="40BB62B218E8814B" modified="2017-08-30" version="1">MQADNVQAGVKDLAKKLVSLDPVDFDSAVNQYFEAHAVLESPQFAVNGASRIKQWCLVQTYPASESKLVGEPRYDEKTQIATFSYQRTYITPYIPVASFLSQKRKVLNFDAKLRLNVVEDDEVDLLVTKASVRRRELAPFEGFIPWDLFRPLLSFAVIGLFVTAGFLFRHNPKQENIAAIGYHAVVEAFQSVWIFLIGEKERVQAKATKYGDAQREKIMGLVQRARSTAGNLKRDAEVGAEKAGDEFDQIKQSGVVYLEEAIQVVDDTKSKGEDKAQELSTEARAYASGFGQKVQGVAEDVESRVEGSFDEAQQDVPEGAKTPLGGNNPQAYNAPSYAQAAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXD8</accession>
    <name>A0A1Y2AXD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_539963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXD8"/>
    <dbReference type="FunCoup" id="A0A1Y2AXD8">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXD8"/>
    <dbReference type="InParanoid" id="A0A1Y2AXD8"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF24">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="98"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY26887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="497" mass="53324" checksum="8EFB5804CF53BE8F" modified="2017-08-30" version="1">MSATTIPTTSPTLADQLLGLTFPSSPPPALLARFAEEYAIPSYLAGSGLRRGSIEGDDGRRSPPEPYRDPDAMLNTFIQHLLNPEHADTQPNLLAIGYELEALLSMYPGSVKLCVSSRPSSIYHVAELEVAGIPSSSSMGGEGRQASQAWTDAVADEALGLAGGERIRYEVTLPAWEDGDAPQGVEAGAEVPRLRVLVSLPPTYPDSSPPQLQLLGRYVGNYGIDAGLFGDITRTYITSSGVPFASGDVCVFEGLNHVQSLVRTWYASHLSSAQTSELERKKPLALALTSQSQPLSRTSTPDPTSAEMRPSPSRATFSYTRHQKSSSDGTETPSAITNAEAGLPVGLTIISSDPIHDRKSTFVGHAIRVTDEREVPLVIHELLSDKKIAKAAHPAIFAYRIVKDVGGVAGKVINSDYDDDGESAAGARLSHLLEILELENVLVVVTRWFGGTLLGSDRFKHISQAAREALEAAGFLDEKEKEKEKESGGGNKRRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZZ4</accession>
    <name>A0A1Y2AZZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_469083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZZ4"/>
    <dbReference type="FunCoup" id="A0A1Y2AZZ4">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZZ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AZZ4"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="204" mass="23035" checksum="7AFADC1B7B21FCA4" modified="2017-08-30" version="1">MATTAASSSKMEMNPRGIPRAPFVADVAEYIAGKNGDVEGVVKTFQETSAKYRYMELSLQQRRKALTTKIPDIDQTLNVVKYLQLRRRKAAGEEITEETDGDEDDDLDDLEEPTEEGALKTLFELNDTLYAEAEIEETGEVGIWLGANTMLLYPLDEANELLSTKLAAAKKSLEETVEDLEWLREQVTVMDVNFARVHNWDVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B008</accession>
    <name>A0A1Y2B008_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">BCR39DRAFT_536438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B008"/>
    <dbReference type="FunCoup" id="A0A1Y2B008">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B008"/>
    <dbReference type="InParanoid" id="A0A1Y2B008"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="341" mass="37673" checksum="107435CC3DD45477" modified="2017-08-30" version="1">MKPIILQGHERSLTQIVFNAEGDLLFTASKDHIINVWFTSNGERLGTFGGAVGGAKHNGTVWTVACDSESKYLMSGGADNTMRMWEVNTGKCLKVWEYETAVKRVAWSEDDELVLGITEQRQGQPSIIRVYALNREDGASQSDEPIQTITLTGSKATVALFAPLSDNILVGHESGKVSKYSVKTGEEVLVNEDGHRGEITDIQLSPDGTYFITSSKDKTARIWDSETLDEMKVYATETPLNSACIAPLRPYVILGGGQDAMAVTTTSQRAGKFESRFWHKLFEEEVGRVRGHFGPINTLAVHPQGKAYASGAEDGFVRVHWFDESYFRSRPFGDLEPEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B017</accession>
    <name>A0A1Y2B017_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_535937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B017"/>
    <dbReference type="STRING" id="71784.A0A1Y2B017"/>
    <dbReference type="InParanoid" id="A0A1Y2B017"/>
    <dbReference type="OrthoDB" id="2561731at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="174"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="564" mass="63050" checksum="31D5F3E1B5323C8B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B033</accession>
    <name>A0A1Y2B033_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_535941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B033"/>
    <dbReference type="STRING" id="71784.A0A1Y2B033"/>
    <dbReference type="InParanoid" id="A0A1Y2B033"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="288" mass="30078" checksum="377A8955D835F81A" modified="2017-08-30" version="1">MTHTNGNSDGLSAARKAIIPNRLKDNIEQGKLAHSFSLKLIANIEVVHYAAVSGYDAVLIDLEHGSFGLDITNQLSCAALQAGICPIVRVPANTSDWISRALDGGAQAVIVPHVQNAAEAENVVRCAKFAPIGERSATGGMPILRYANIPAKYGNQVCNEGTTVICMVESVRAVEQAESIAAVPGVDMILVGHGDLTQDMGIPGEFDDPRVGEAFAKVCAAAEKASKNGRLVSVGIGGLHGRPDLIEKLGKKHPNARFAMSGADSVFLLSAMASGAAISQRITQSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0D5</accession>
    <name>A0A1Y2B0D5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_535380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0D5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0D5"/>
    <dbReference type="InParanoid" id="A0A1Y2B0D5"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="98"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="538" mass="58879" checksum="67F51744CACC6234" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0J5</accession>
    <name>A0A1Y2B0J5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_536162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0J5"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0J5"/>
    <dbReference type="InParanoid" id="A0A1Y2B0J5"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="197" mass="21650" checksum="142E8CDF2D74FE4E" modified="2017-08-30" version="1">MSLLPRYLIRSRPSIPSPSLSFRNRMLHTSRPLQAETRGPVDPPPAPAGAAPHTAIMDVVAGLAEGPVVPVEDASVVAAEVVSGAPHELQLRQVRIFKPTKSTMQSAKGKTKRWVLDWDVLQGAGRWENPLMGWASSADYMQGTTLGFRSKEAAISFAERQGWDYIVSEPKVAKIPPKNYANNYVHVPGKLRIHHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0T0</accession>
    <name>A0A1Y2B0T0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cohesin loading factor-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_537919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0T0"/>
    <dbReference type="InParanoid" id="A0A1Y2B0T0"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="78776" checksum="DAD517670F71B3FF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B175</accession>
    <name>A0A1Y2B175_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_535421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B175"/>
    <dbReference type="FunCoup" id="A0A1Y2B175">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B175"/>
    <dbReference type="InParanoid" id="A0A1Y2B175"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="253" mass="27190" checksum="0DEBD3B3C8C03B90" modified="2017-08-30" version="1">MSAPGGSGGAYSFSLTTFSPSGKLVQIEHALAVVAGGTTSLGIKATNGVVLATEKKSPSLLVDSSMIEKVAPICPNIGFVYSGMGPDFRVLVAKARKIAQAYWKVYGEYPPTKVLVSEVAGVMQKATQSGGVRPYGISLLIAGWDAHRGQSLYQVDPSGSYWAWKASAIGKNMVNGKTFLEKRYNDDLSLEDAIHTALLTLKEGFEGQMTEDTIEIGVVTVPTAEQMQEKPGERPPPTFRKLTEQEVRDYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B182</accession>
    <name>A0A1Y2B182_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_534308</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B182"/>
    <dbReference type="FunCoup" id="A0A1Y2B182">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B182"/>
    <dbReference type="InParanoid" id="A0A1Y2B182"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="13">
        <location>
            <begin position="43"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY28599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="263" mass="28477" checksum="B462697ADD63E937" modified="2017-08-30" version="1">MPEDNQDMASTSTSTPPSAPQAEMAPMSRSNRPTIVGPDIGPEAPYPLRLEGTVTKGFGRGARFLGIPTANLPDSSLGPLNDLHLTGIYYGFARVHPSPPTTASNPASAIQSGTSTPLLSLSNPLDGASISAIPAETAPYPPDSVVPGEEAGEGDGEIGKKGKRLNQEDSRVWPMVMSVGWNPYFKNEKITAEVHIMHPFQHDFYGHHMSVLVLGYIRPELNYVSREALIDDINFDVKVALNCLAREGYATFSTDPFLFRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2D1</accession>
    <name>A0A1Y2B2D1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_588512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2D1"/>
    <dbReference type="InParanoid" id="A0A1Y2B2D1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="94" mass="10359" checksum="9AC46287EFF39DF3" modified="2017-08-30" version="1">MQTITARRIIGVGMVTLLPAGIYAGYVWNESLRAGELAEMVPGAVVSERAIRARIVDLAHERNELLAEQDHITGKIEELRHRIAAKKEKSNAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2F5</accession>
    <name>A0A1Y2B2F5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_535192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2F5"/>
    <dbReference type="InParanoid" id="A0A1Y2B2F5"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="298"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="508" mass="54929" checksum="2B41EC4B2471C661" modified="2017-08-30" version="1">MSRPSSPPPHLHHTLSRILSMTTAAPSHRTHSRTSHFSLAPIRSNLLDDGLDNIPPPLPHDHKQLERRLTQDPDVERQMRGSGDGEIGPPPEGGREAWLVVASSFFILFCVFGFVTSFGTLQVYYLSHQLLGYSKSQVAWISSVQMFLTFAGSIFAGRIFDSHGARGLAIAGSSLSVGAIIAIAFCKEYYQLMLGHAAFGLSGSILYSPGTAIAGHWFMRRRSTATGIVVCGSGLGGVIYPIALKRLFDQLSFRDTMLIIAGMNAFLMLPSWFFMKARLPPRQPPPLRALLGPWKEPRYAFLVIGSCMIMMNWVSPYFNAPTLATSNYLPTNIASYSVAILQAGSFTGRALSGVLADAVGVWHMYVLMALLQAVVIFAFWTASPLPAAAVVVGLAGYGFASGAWITLVAASMGAISPTREFGMRLGMLWSLSSIPLLIGPVICGVLVGVDSGKFSYAAIFCGFTFLIGAALAVSPRALEMLAQVCAQRKRSLQQEQPREGEEDEGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2Q9</accession>
    <name>A0A1Y2B2Q9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_177223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2Q9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2Q9"/>
    <dbReference type="InParanoid" id="A0A1Y2B2Q9"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="69"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="474" mass="53619" checksum="3EF40A0A7C017A43" modified="2017-08-30" version="1">METDKQVAKNRPDLKIIVMSATLDVGKFSRYFGDGSPTGLAPVVKVSGRTFPVETFFTQEPETDYVEAAIRTVLYIHQAEDEGDVLLFLTGEEEIEDACRKIRAEGEELANKGMAGPILVLPLYSSLPPHQQQRIFDPAPPARGNLPGRKVVVSTNIAETSLTIDGIVYVVDPGFCKQKVYNPRIRVESLLVSPISKASAMQRAGRAGRTRPGKCFRLYTEKDFVKELEEQTYPEILRSNLANTVLELIKLGIKDLVHFDYMDAPAPETIMRALELLHYLAALDDDGNLTPLGEIMAEFPLDPQLAKMLIVSPEFGCSNEMLSLTAMLSVPNVFMRPASQKKEADLARAQFTHPDGDHLTLLNVYHAYKQNEANAKDWCWQNYLNMRSLSQADNVRTQLKRSMERFDLELCSTAWEDKNYWNNIRQALTCGFFMQVAHKEGERGSYLTVKDNQVSFDDDLHNHISISRRRKRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B314</accession>
    <name>A0A1Y2B314_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_177352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B314"/>
    <dbReference type="InParanoid" id="A0A1Y2B314"/>
    <dbReference type="OrthoDB" id="2565052at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="490" mass="54092" checksum="802133A56032E463" modified="2017-08-30" version="1">MDDGSGSGGWNSPTFAVNAQGQEDSDIASATVVNPYYWPSSTMTIPTPTTVIDSDSASTSTRGQRMRLSSSSTTTTTTTPMLYSIPPNSALTPFSISFSSLPTGPPPPLLQDTHTASRPSVTAIAVPLAICGLIALVGLIFCARSRLSRGRSRDIESVSTSTTTTGLSEKEKGVTVTRHDEPVLALPVLGYRGSQSTPYTRSRHEPYYLRDEEHARKSRGGKREDDWFTSIPHINYRTSYDYTHRDDDWHGNHPRSNNMDYYSPRRLSPMHLGGARMDNRCSCSHSHSDSGARSIHSHSNSGVAGFHSQSRSTMNPHSNSTPNPRPATLSYSSPQSRPPPHFQSRPDYTHSHSHASSRSTPRPHYSRGLSRNSLDGSMHNPHRRPLPTYPIIRTESASTQGRFGLDQVHGKGGKAPNQTGALRRSESRETCTEFEWNRDRSVRDRNTNREGSMYVDRDRDTSGRGRGDRGEEGMEGLYESLRRAIGTPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3E5</accession>
    <name>A0A1Y2B3E5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_532437</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3E5"/>
    <dbReference type="FunCoup" id="A0A1Y2B3E5">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3E5"/>
    <dbReference type="InParanoid" id="A0A1Y2B3E5"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="48"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="243"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="562"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY29349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="612" mass="67223" checksum="F250A0946B403A38" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3Y6</accession>
    <name>A0A1Y2B3Y6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_533910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3Y6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B3Y6"/>
    <dbReference type="InParanoid" id="A0A1Y2B3Y6"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000051">
        <property type="entry name" value="F-box and WD-40 domain-containing protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000987">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF681">
        <property type="entry name" value="F-BOX PROTEIN MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="136"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="339"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="386"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="426"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="673"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="713"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="758" mass="83228" checksum="BBFE895900D72B48" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B469</accession>
    <name>A0A1Y2B469_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative ATP-binding cassette transporter protein YOR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_531296</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B469"/>
    <dbReference type="InParanoid" id="A0A1Y2B469"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="982"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1086"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1167"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1272"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="293"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="683"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1088"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1368"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY29629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1633" mass="179320" checksum="C89DE756F52D3C5D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4K1</accession>
    <name>A0A1Y2B4K1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_588526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY29005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4K1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4K1"/>
    <dbReference type="InParanoid" id="A0A1Y2B4K1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="473" mass="51103" checksum="5166394A365B3367" modified="2017-08-30" version="1">MESPSPRDRVILIGGGIIGLCTAYYLLTLECPDRHPPNVTLLERTETIACGASSRAAGLVMREWHDGRVLPLSRSSWKCWEEMNRKMDDGKGWNWRNIGAWGMDVDMDMDEDQDEDQDEDQDEDSNNKDGKEKGGRSQYRLLPETRERVEEAEEMRGRAYKLGKQDCIAAVDPALFCQTLLSKCQSLGLDYHASTQAASLDTANKTITLADKETLGYSTLVLSSGPWTAHLARALNLPGVAISNLPGHSVIIRPSRSLSDGVVRHCMFVGVDAGVEGFKVARSATGDEDDEDDDTAGWTDSIELVCRPDGTVYVAGENSAPRSSRPPPPSSSSSSRPPSSRPPSSRPPSSSHASSSGGLPNHLPLTPEDVLSLTDKKLVKRLLCSAAATSRLLDVSRGATLVKSQLCYRPVTPDGRPLLGPIGEGVNDVFVAAGHGPWGITLGPGSGRLMAELVLGLKPSIDPKAFDPSRFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5Q2</accession>
    <name>A0A1Y2B5Q2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative carboxypeptidase s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_529795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5Q2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5Q2"/>
    <dbReference type="InParanoid" id="A0A1Y2B5Q2"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="301"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY30169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="617" mass="67734" checksum="D97E4D423885F085" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6A7</accession>
    <name>A0A1Y2B6A7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_573992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6A7"/>
    <dbReference type="InParanoid" id="A0A1Y2B6A7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="450" mass="50162" checksum="C6F3CCC06B97747E" modified="2017-08-30" version="1">MSRIHAQFLANPGFYLRPMLRVVSVSNSISRLGGSVGFPSYETVGDNFTDAATRALSATWSFASNALQSFPTQALKSAQSYCTEALRTAITAAAQKAQSFITATADFRARTTATSFTTLAKATEPPFSSARKPTNTFTTATATRVRAAGPSTTGAPETADSFTTIAPRTEELLRTELFPTTTTPISMSRTSSTPSRNAKRKRRTPERQGYVPLSSDPPDLHTRPFSIYFKPSALPSTLKCRFESRKRDPGTSAGGSRYSRRLKKRNPQTESKLTGSRPGKSTNRLKSSEGHLGASKSTGGSKRSRRLTKRKPQTKRSFIGSRRDPSTNKSQLRKPKPKPKPSDPKSSFIGSRRRQSGVPTTLRKKRLPVYHRKNSHMSNYYSKKTFQYVLSKQEWTASGRDKLLDPWTAKRVKDVERSYDLHVRAAKKRHRKPGTVTRLWNSITTRRSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6B4</accession>
    <name>A0A1Y2B6B4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_150220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6B4"/>
    <dbReference type="FunCoup" id="A0A1Y2B6B4">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6B4"/>
    <dbReference type="InParanoid" id="A0A1Y2B6B4"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="182"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY30373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="407" mass="45234" checksum="ED80A4FBDE48A6F5" modified="2017-08-30" version="1">MSVATQKMPKIPSSTPGGSIKTYYQNKIEAAELDITKKTQNLRRLEAQRNALNTRVRLLREELQVLQEPGSYVGEVIKVMGKKKVLVKVQPEGKYVVDFSPDIPISSLTPNLRVALRSDSYLLHSILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCRFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRGGEGGGGGDSEVQRTMMELLNQLDGFEPTKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNPEARITILKIHSRKMSLQRGINFRSLAEKMGHCSGAEVRGICTEAGMYALRERRQYVGQEDFEMAVAKVLKKNAEGNTSVNKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6U7</accession>
    <name>A0A1Y2B6U7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small subunit of acetolactate synthase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_528751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6U7"/>
    <dbReference type="FunCoup" id="A0A1Y2B6U7">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6U7"/>
    <dbReference type="InParanoid" id="A0A1Y2B6U7"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="365" mass="39307" checksum="F50219BD2ABD0AEF" modified="2017-08-30" version="1">MTCKKAKLIALITKKSLTMSLRKAATSSANLRSFVRCASTTAVRNAPAPKSIDDSTSALDYKMHRTGVRLPHLTNQHPRSQTAEEAVTNILYNTPPPSTEPYKRHLLNCLVQNEPGVLSRVSGILAGRGFNIDSLVVCQTEIRDLSRMCIVLRGQDGVIEQARRQLEDLVPVWAVLDYTRTPTIERELLLAKVSILGPEFAQAQLSPTGSDASASLDAAIEAQDPANPPGFVDASGDKVAREQSLARTFESSGAAPLYPSRREGPGMSASEVLIAKNLHLGAIKTLTDQFGGRVVDVGEDSVIVEVTAKGRRVDAFLNLMRPFGLLEAARSGVMVLPRTPIPDYGEEEAAVEEVGEIDASMLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6Z0</accession>
    <name>A0A1Y2B6Z0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGF29 tudor-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_529122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6Z0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6Z0"/>
    <dbReference type="InParanoid" id="A0A1Y2B6Z0"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="112"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="268" mass="29433" checksum="1C6A9AF3D69ECED0" modified="2017-08-30" version="1">MSGGRGRPSLSRKAMPDNELAMTQTWHGLVDTLRLLPTIEDDRPANRQTLDDALDKLSVLIALRRGESVPPETVAASTPGVVMAKRKRSSSPGTPMSRELSGRQQRRDAYADQLPLAPGRKVAFRVPGQEGENWILATVRKCIQQDKMRYEVEDDDDKQTYNTTLRSLIPLPDPNAPIHTSAHPSNLEDFPKNAQVLALYPETTTFYRATVRSAPIPGTGMGLGVRGGSAAPKADREAKAEKYRLVFVDDGDNVLEVHKNLVVPFPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7A7</accession>
    <name>A0A1Y2B7A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Heat shock 70 kDa protein C</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Transcriptional coregulator SSA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_528762</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with transcription factor HSF1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7A7"/>
    <dbReference type="FunCoup" id="A0A1Y2B7A7">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B7A7"/>
    <dbReference type="InParanoid" id="A0A1Y2B7A7"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000056">
        <property type="entry name" value="Putative Hsp70 family ATPase KAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="9 18" id="KW-0346">Stress response</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013276978" description="Heat shock 70 kDa protein C" evidence="17">
        <location>
            <begin position="43"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY30566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="676" mass="74106" checksum="2645ECC9E0924D13" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7C2</accession>
    <name>A0A1Y2B7C2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_494681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7C2"/>
    <dbReference type="InParanoid" id="A0A1Y2B7C2"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="570" mass="63118" checksum="97C9E892B781551D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7D2</accession>
    <name>A0A1Y2B7D2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_113253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7D2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B7D2"/>
    <dbReference type="InParanoid" id="A0A1Y2B7D2"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="396"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY30596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="565" mass="61875" checksum="87D98B784B14BF30" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8C2</accession>
    <name>A0A1Y2B8C2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_527666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8C2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8C2"/>
    <dbReference type="InParanoid" id="A0A1Y2B8C2"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="234"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="457" mass="49058" checksum="076BF4B423BAC203" modified="2017-08-30" version="1">MSTSPTRGGKARKSAERGMRTGQAGSTEIRLPPSASQAPKANGFKPTFGSIQPGSESGSSTVPVTEDVNQTEASMSSGNASAPLSRQSSAQPRRDSTSKPGKLIPAEATPVSNGSAPITASHTAPIPQNPHFMGMAGHMPRPSRGRDPRAPFPNRGRGGMFRTGSVPHKFTSPTNGFIPLPGQEGFAGMNLYQRGYGMGFPGYYMPGPGMYDPMQVYGRQGVTVPPPPMPQTFVQGLDSLRFYLLGQVEYYFSLQNLAMDFFLRQQMDSEGWIDISTIASFNRVKSLTQDQSLVKEMMNLSSLLEVREDKVRLAQSYKKWVLPDAKPSTFEADPTSPVLASGEQHRIADDVGMTMMNMGVGMEMGVGEHPFGDDIQKKYEYEPGGVQGALMKSASSNTTVQPLPSTSGESTWTAPGDIEADDSMEKSEDGSKVDGMTETPATSMSGDTKDGHEVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8E8</accession>
    <name>A0A1Y2B8E8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macrofage activating glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_528410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8E8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8E8"/>
    <dbReference type="InParanoid" id="A0A1Y2B8E8"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012169235" description="Macrofage activating glycoprotein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="40150" checksum="1E6E9C21F40D6BB5" modified="2017-08-30" version="1">MISPIRPRNTILAALPVMAIASAQYTATYYVGSLPGSSEEGQSGTNACGTSSSQSSECQNVYVNSVSDFCLWGPPATTSDEGDGTSKIGNVEQVVVSYCLNDGYGTRIIPAGTITGAHFIKVQSEKVSYVQVNGVGDLTSLLIPAGDDGGELDPHSWTGLGNPQGGLVFTNALTGSYEQTHEWTSFIDAGSFCIRACQDGPNAAGYCQHIYDTLSCDFTVPGDSSAGSFTDCLSDPTDEEPGVYDGSTFYQGASSTPAPHPAGATSACTTYSTIGGGSVNLAASPSSSSSSSTSSSSTSSVITTSSSNSASSTSAASSNSSSASAAASSTSASVSSTTSVSASSTTSSLSVSRTPSPSASRSASASVSIGAAAASQSTGAGSKTAMGGVSVFTAILLSGLGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B987</accession>
    <name>A0A1Y2B987_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_465781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B987"/>
    <dbReference type="STRING" id="71784.A0A1Y2B987"/>
    <dbReference type="InParanoid" id="A0A1Y2B987"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001062">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000747">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="690"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="770"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="123"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1068" mass="116027" checksum="34452C39FCF784E6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9R4</accession>
    <name>A0A1Y2B9R4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hyaluronan-mediated motility receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_558076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9R4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B9R4"/>
    <dbReference type="InParanoid" id="A0A1Y2B9R4"/>
    <dbReference type="OrthoDB" id="2596629at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031794">
        <property type="entry name" value="HMMR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15908">
        <property type="entry name" value="HMMR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan-mediated motility receptor C-terminal" evidence="6">
        <location>
            <begin position="504"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="444"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY31611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="639" mass="71807" checksum="298276FE00688B55" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9Y6</accession>
    <name>A0A1Y2B9Y6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_526176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9Y6"/>
    <dbReference type="FunCoup" id="A0A1Y2B9Y6">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B9Y6"/>
    <dbReference type="InParanoid" id="A0A1Y2B9Y6"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF20">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="56"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="377" mass="41031" checksum="1073265B3B114801" modified="2017-08-30" version="1">MYPTHQVSVREAMDMLDDRRVKVVRPLIPPQILLEEFPLTLRGAQTVLDGRRQVEAVIKGDDDRLLVIVGPCSVHDPEQALVYARKLKEYADEAKEDLMIVMRVYFEKPRTTVGWKGLINDPDMNGSFQINRGLKIARKLLLELTELGLPAAGEFLDVISPQYLADLNSWGAIGARTTESQVHRELASALSMSVGFKNGTDGSIGIAVDAIKAAGSGHTFLSVTKQGLSAIVETEGNNSTHVILRGSSSGPNYEAQHVISAGEKLAKAGLATKIMIDCSHGNSSKKHENQIIVGKNISEQLVSGPSSQMIMGVMIESNIHEGKQSVPPEGPSGLKYGVSITDACISLEQTWPLLDELRQGVRKRREGVLAKRINGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA85</accession>
    <name>A0A1Y2BA85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_79124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA85"/>
    <dbReference type="InParanoid" id="A0A1Y2BA85"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="136" mass="14071" checksum="7E76125450DD5FCD" modified="2017-08-30" version="1">MPLPPDDSLPEENTASSSQTSSLKTPQPTTEEMIEKFKQLGAEAAVEGAEDDAEDDDDGVEDGEPDEEAGASVGGGGEAVKKKKKKKKGKASKAVAKLKALTTGQAPQEVVDAVRENMGPQDAPVNDGLLNGCHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB88</accession>
    <name>A0A1Y2BB88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fatty acid beta-oxidation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_524163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB88"/>
    <dbReference type="FunCoup" id="A0A1Y2BB88">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB88"/>
    <dbReference type="InParanoid" id="A0A1Y2BB88"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="293" mass="31251" checksum="EFAF058E0A065CD1" modified="2017-08-30" version="1">MAARLRLAHKVCIITGAGSGIGLETALQFAAEGAHVMLTDINEAAVLKAAELVNSSFPNCKANGIKCDVSKELDVKTVVEKTFETYGRLDVMFNNAGIMHGDDDDAVNTEERIWDLTQAINVKGVWYGCKHAIIAMRKNKPNPELGLGIGGSIINVASFVAILGAATPQLAYTASKGAVLAMTRELAMVHAREGLRFNALCPGPIRTPLLMDFLNTPEKLGRRMIHNPMGRFGEAVEQAKAVVFLASDDSSYINGTDFLVDGGLHACYVTSEAEQIVPPPVGLLASKVEKGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBC8</accession>
    <name>A0A1Y2BBC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_593285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY32006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBC8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBC8"/>
    <dbReference type="InParanoid" id="A0A1Y2BBC8"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF40">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="174"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="503" mass="53710" checksum="A7019BF1AF6EC326" modified="2017-08-30" version="1">MSLKPPPPPPRRSAASSSVSSSHSSPDPAAGSTWKSRMKAKGASWGKVAVEKGTKISDNVGGKVNNIAEKRFGTEAFWPVTGDFPKEMDKCARILRAFTVDGVITESKDKDKKKGRKVLRKIPPAVIQQAKGLAIFTSMRTGIAPFGGAGGAGLVVAKLPDGTWSAPASITPNNLSAGFMLGVDVYDCILVIRSQKALDSFATHKATLGTELGVAAGPYGAGAAVEAGMEKAPLLSYVRSRGVYAGVELVGQVFIERFEENAHMYHWPGVKAGDILSGKVRIPVEAANLQKALQDAESGKAQMEKGGAIDIIIPDDTELDLADGEVLKLPPTPDQTDGTEHQSDPETERVHYPSRPVSTASSRVDLIHPTPRAPPPLPSRRPPILTHRSSTSNYSDAEEDLPGSSIATRDAPPSYATEYAQVTRDEYPSEKSVPVQGIAGMEGYDENEPMTEAERREWEQFYAEHVGEGSLAAAPEADGGSVEVVTEGLSRQHLDTEEDHSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBD7</accession>
    <name>A0A1Y2BBD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_59992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBD7"/>
    <dbReference type="InParanoid" id="A0A1Y2BBD7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="376" mass="40575" checksum="98771B26085A5394" modified="2017-08-30" version="1">MDIDVDARVIEAAEQQERVREQGQDDSWLNQFRAYQQQQGQGQGQEQVQAQEQEHQHKASSSSARFTETFSSSRTQIDPPSSWSFDSSPSHTLLRLDHASSSSPSPSSPSSPSSHDRDNVDLGNSPSSPLSSSHSTLHPPRLSSSIRPKSKPIPIVLSHKGNSRSLTRHSPYPPVSSLRSTSSTMTPSTSARHTLPPSAHATPPSLSAAAAARLTSPTPSMSSSNRRRQAPLFPNSPRQDRDHVPATLTPTQTAAIPYSPFRSAYSHAPRPPRQVGVPITPRTASHLAHHPYRPPPSASAPSKLPDPAYPITGPYYLVPSPTRRNAKGEPEMDVVPAVPTAAAILHLKANAGKFWNAPESADIVLSASLSFFADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBP7</accession>
    <name>A0A1Y2BBP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_524310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBP7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBP7"/>
    <dbReference type="InParanoid" id="A0A1Y2BBP7"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase (KR)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="313" mass="33623" checksum="A86265FD5270486F" modified="2017-08-30" version="1">MSGIANQGLEKVSLQGKGFTIAIVGGTTGIGAAIARCFAKLGAERILIVGRNEERAAERIAEMDKLAPAGLKTNYEFVKGDISDLKGMKAAAASLEKIAGTSGITHFIMCQNGIPATEIQTNADGDENGFAVQALSRFTLAYLLLEHNVIAPGGVVLAVANPGLSLDTLSVDDLSLKKVAEAGRSKLLLFLDCSKRDSTVLDSVFEELSKRYPKQRFFHCHPGVVATELFNTGAFPFPMNLAVSLALWTIAPKPDDYAVVPVYLAVGSDIEEKYGSEKFFTSKLKPSPLGTWASNAENRQKLWKKLEARVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCT1</accession>
    <name>A0A1Y2BCT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketopantoate reductase PanE/ApbA C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_464643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCT1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCT1"/>
    <dbReference type="InParanoid" id="A0A1Y2BCT1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF43">
        <property type="entry name" value="KETOPANTOATE REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="217"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="382" mass="41688" checksum="F657E51744E3E4B1" modified="2017-08-30" version="1">MVTTSEASSNGEVVDILLIGLGSIGSVYAYMLEKSGRVRVTAVARSNYDLYTKSGVTLDTDRFGKITGWRPYRVVKTQAEALEGNVHYALCMICTKCLPDVLPTPTLVGDLIHSGKIGAWALLQNGLGVEEDLYQAVKHLDTPIISNCIWIGVMTNPDGSIVSWKGQDAMVAGIYPPKKPMQEEQTRVFSAKESGVLDLWVDALTAGEAKIKVDERIDGVRFSKNVWNCVWSSIQGLTRATPNYFAHHSAAEQAPLRAFIREIVETGFRAGLLREGMPLYPAGTPMGSSAEVQRAAWDSIVNMSLEKAKQGIPPHRMSLLIDVEMGRPFELEVITGAVAKVAKSHGYETPFLDFTYSLLKGVQNNIIDAQKKKNGGSFVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCX8</accession>
    <name>A0A1Y2BCX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_522894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCX8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCX8"/>
    <dbReference type="InParanoid" id="A0A1Y2BCX8"/>
    <dbReference type="OrthoDB" id="58379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="31413" checksum="206122480F00A610" modified="2017-08-30" version="1">MGLFNHQPSDSKVPHLPSSSPSASKADQATMYPHEKPRDPPSYQPPPITSSFAGPSRPVAPTYAALHLAKTDRVRLIGFPPDAQRPVNDAILRAWPVGIQQQGPFDASSYEWKLSGRPWSGQGSEAVPARRLMSHLLHALSASGWHLAMSVDLSRKGWDKDTLLFRSGPGLQRYFFSVSFNEGDKVRIIDPPNEVTKQAFIDAISTWPLGIQASKEKEPACHQLKLRGNPWWTSDGHQINQSRLLACAILSAMDACGFELVGSVDMSVGTGDNNLDLDSWFFASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCZ1</accession>
    <name>A0A1Y2BCZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_522946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCZ1"/>
    <dbReference type="FunCoup" id="A0A1Y2BCZ1">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCZ1"/>
    <dbReference type="InParanoid" id="A0A1Y2BCZ1"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013345064" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="127"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY32576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="401" mass="43077" checksum="75E11BC9F06A3A96" modified="2017-08-30" version="1">MRFITALFLSAAALASASNVIDLDTKNFEQYVGGDRPALVEFFAPWCGHCKNLAPTYEQLAGVFPSDKVVIAKTDADGVGRELGTRYGVQGFPTLKWFPAGSLEPVDYEGGRDLDSLASFVTKETGAKSKIKAPPPPAAVQLDASNFDDIALDSDKNVLVAFTAPWCGHCKNMKPAYEKVAKAFSSESDCVVAQMDADAADNKPIASKYDVRSFPTIKFFPKGSNEPVAYSGGRSEAQFIEFLNENCGTHRTATGLLAETAGKVLTLDKLASSFFSAQVPDRAAIVDKAKEYLASANKTTRAGADYYVKAMERILEKGETWVLKEQTRIAGLLGSPSLAPTKLDELKIKANILSSFAATKAEEAYDAAADAAEYVTENVKDAAGQAVEGVEGFVERVKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDE7</accession>
    <name>A0A1Y2BDE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_582991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDE7"/>
    <dbReference type="InParanoid" id="A0A1Y2BDE7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="136" mass="15499" checksum="36427CFE322DF4A2" modified="2017-08-30" version="1">MSEEARLNEIIFEQAAGAIDYIQELEEAYYSDRGRIAALLEVYLQTLVNDVTEMEDDPDMVMAEEVGEAVLSACADILAYPNLDHSRHIRSIILLRQMMCPGTDMGVWTDDDVDEPPVSMQWPWDVTDLWDEVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF35</accession>
    <name>A0A1Y2BF35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_491763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF35"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF35"/>
    <dbReference type="InParanoid" id="A0A1Y2BF35"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000164">
        <property type="entry name" value="Chitinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="388" mass="41449" checksum="9DC6DB948BC07BB5" modified="2017-08-30" version="1">MAGYYPDWSGDYLSPENVDWSKFDVMDFAFALPTSDGNLEFTQDDSSDLLKRLVSTGHAAGKRVKLSIGGWTGSAYFSTICGSKSLRKTFVSNILTAYNSYNLDGIDIDWEYPGTGGASGNAVSSSDSAHFLTFLKDLRAALPSGAIITTATQVWPFADSNGNPMADVSGFAAVIDWILIMNYDIWGSSSTPGPNAPLSDACGNSTQPLANAYAAVSSWTSAGMPANQITLGVPAYGYLQKSSADHLIQRRGLHPASRHSTSPSSNKTDTRRRRSDITLYNTDGGTTDGQVMFEDLIQQGVLVSDSSTGSYIGAGGFVREWDSCSSTPWLKSKHSDQIVTYDDPQSMSLKGQFAAQAGLRGCNVFSVDGDYINGAWPLTDAVRSGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF45</accession>
    <name>A0A1Y2BF45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF45"/>
    <dbReference type="FunCoup" id="A0A1Y2BF45">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BF45"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="333" mass="36654" checksum="5DEF7C937E440294" modified="2017-08-30" version="1">MTTNSGASSSDHPALPIIPLNSFPNIESLGSALYSACTTDGFFYLSEHGISSELINEAFDVAGEYFVDAPSEERIPGIKNMGYTAVRAETLDSTTRGLGDLKESFYMTNPAWKDESGHEQSLPPTLQGKRERFEKLIKSCDAVADKVLRGLGKALGLEEDFLSKHHTGLECKLRMIHYPPVQVEYQHPDPTIPDIRAGAHTDYGSITLLFQHAVSGLQVFKRGEWLDVAPLPGCLVINIGDALEFWSGGQFTSTLHRVVMPRTANEAKSRFSIAYFVQPENDTRLDPLLSDSGISEEAFEEIIARKGLPRGTRDLTGGEYLRIRIDATYKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFI5</accession>
    <name>A0A1Y2BFI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_522054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFI5"/>
    <dbReference type="FunCoup" id="A0A1Y2BFI5">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFI5"/>
    <dbReference type="InParanoid" id="A0A1Y2BFI5"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="553"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="646"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="677" mass="72297" checksum="8C0F582F6AD79C5F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFM5</accession>
    <name>A0A1Y2BFM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_522283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFM5"/>
    <dbReference type="FunCoup" id="A0A1Y2BFM5">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFM5"/>
    <dbReference type="InParanoid" id="A0A1Y2BFM5"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="195" mass="21501" checksum="5E36C840FF4C5028" modified="2017-08-30" version="1">MFLLGHNLPDTKLVRIALTSFYGISHHISSRLLARLQIHQTCLVNELTEPQITALSAYLSSPNTTPAPPPTPLNTPTPPPFSLVASSSSSSSSSPKTIKVLYEAQRWIDKRPDPLSDLKIETELRKELLANIAHLRQIGTYRGKRHAGGFPVRGQRTKTNGHTAGRLNKIDRRGFSTYAGPTDSPILSMLSRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG16</accession>
    <name>A0A1Y2BG16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_518967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG16"/>
    <dbReference type="InParanoid" id="A0A1Y2BG16"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="200" mass="21944" checksum="0FE04B4BC10D5597" modified="2017-08-30" version="1">MNRTTKSPTRIPAFKSSHTLTLTASTGNLGIGRYYLDRAAMPLVQGKLSLVDFSAAMAAFSSVRLETLREAWGMFSHPNEFVAVRTQAFFLSVLRCQVRSVRHVSFSDAIRDSIITSGIPFSKISYSITSTSPSPGPIQLRHIVKAYLSYTSGSRSTYTRPTRIGLVLFKCGTLQRSGTVLSVWSAKTTSPKWSRGIRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG21</accession>
    <name>A0A1Y2BG21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial transcription factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_519166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG21"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG21"/>
    <dbReference type="InParanoid" id="A0A1Y2BG21"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="600" mass="67339" checksum="093572919B998B87" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG36</accession>
    <name>A0A1Y2BG36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG36"/>
    <dbReference type="InParanoid" id="A0A1Y2BG36"/>
    <dbReference type="OrthoDB" id="2573559at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="683" mass="72914" checksum="B09A530C4EF63476" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGP5</accession>
    <name>A0A1Y2BGP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTLH/CRA C-terminal to lish motif domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_517993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGP5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGP5"/>
    <dbReference type="InParanoid" id="A0A1Y2BGP5"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRA" evidence="2">
        <location>
            <begin position="244"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="384" mass="41953" checksum="95B38F0804A703E1" modified="2017-08-30" version="1">MDTASSSMSRDPESLDDIVLDYVTTHAFASTAKILSRPRRSAPRAAETTTHNGTEESVEDNGDGSMDVDHELGDSTESARKAAKRPMYGERLVDSVSLESVERRRNILNHILNGAIMRAVEALETHFPAVLAEPAEIATNGNSKLHLTSGTYSNGSDTPFHPPWSSYSLSAIPPPLPDHAMPVFPKSTHPSHVRLNLQIQQFIESFRQLGPSSPSSPSSSISSLTSSMHMSTSLHHNGTSSSGATLTNALTAAQGLHSEAKKLPAEARAVYLQEIKDVGALFAYTNPETSILKGFLEQGRRIALAEQVNRAVLRSEGRPVESLLETIARRTDAVYSLLLQHAIDPRPGPDEESSKEAEWISNYFRRRGPGITFRTRELVDRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHR8</accession>
    <name>A0A1Y2BHR8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_517685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHR8"/>
    <dbReference type="InParanoid" id="A0A1Y2BHR8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="158" mass="18481" checksum="91AF80BFF9E7C53B" modified="2017-08-30" version="1">MQSRVIGVVQSSNALTGVIHTWYHFVLCMTSRLRVWNTHTHRSYIPVIHLLDRLQGTVRTCRVKFVFAFFYGRVVFMFRVRVRVRVLVRALCQVDPGSRRKSHLIPDNSICVYILEIRKQSIIVSLHFYHDTIVVVSFIRMTRHHASLLVTCTCTLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHU4</accession>
    <name>A0A1Y2BHU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 21.3 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHU4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHU4"/>
    <dbReference type="InParanoid" id="A0A1Y2BHU4"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="22871" checksum="A1715267F2A6D177" modified="2017-08-30" version="1">MVRLSGVIRNAAKSAQAAGKTEPMSADSTLYHLSPTGFWKKFRDAVVVNPEISSGLPVPLLNRYPQPGSRPEKYATPATQASDPAFNPYHKRDVRRAYPQTSYITQSHLSSLLLASPSLASLPAPETATKVPADSSSIAPNAEGSEQAIVTSSVPSLASVLEKLPVGQAFVGAGLDTGKAQAGALPPAPPGLGKKWIPKAGEDIPHDPDAYFPMVGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIC6</accession>
    <name>A0A1Y2BIC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_513232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIC6"/>
    <dbReference type="InParanoid" id="A0A1Y2BIC6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="178" mass="19888" checksum="EC47BECF99C5F920" modified="2017-08-30" version="1">MPQSFPDLLELILNERALSHYSFGYPHAAFCCMVEFQRQNRLVQATMKISMLPHAQKQHTIGALADPESSNLSPYSSVHSSAQFSLWKVPTVSSSIESSSPLPLISPVGVSTGPNKARRYVTLCANVRNIGIIMSVTGCSRNTGVYLISKEVRGRWRVHLQAIRWTPGRYEVMPRQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIQ4</accession>
    <name>A0A1Y2BIQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_513993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIQ4"/>
    <dbReference type="FunCoup" id="A0A1Y2BIQ4">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BIQ4"/>
    <dbReference type="InParanoid" id="A0A1Y2BIQ4"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="135" mass="15642" checksum="6C1B8FC99716C729" modified="2017-08-30" version="1">MGRTFRIYLAGESVFLCRQCGNHLAVGESVLSKAFTGQHGRAILIQHAVNVYTGEAEEREMRTGKHVVRDVFCQVCHSVLGWKYDLAYEPEQKYKEGKFILERELITEKMENKRDLQSDRPRIDEVPVRELMARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIR6</accession>
    <name>A0A1Y2BIR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_556196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIR6"/>
    <dbReference type="InParanoid" id="A0A1Y2BIR6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="337" mass="37094" checksum="BD59FDE5110F6D21" modified="2017-08-30" version="1">MASTTYSMVGEDAITCMQDMSSLWRTPIETQLQRNGLMHLGTKSRWTTANREMTKSGQTLRTSMEGSLHLNCWATIRCPRLKERDMDDCTVTSFNTQLHTGKVSSNSSNVSRDGTLSIGSRKQTHLASLIVIGSASVVRQDGYVTTEAAFMQCEISAETTAVRSLFDQVIIMTLNKPTLESQVTQWLDGALSTPMDLDRDGRCVFKSLWYRTRLGPADFSGGGDRPALVPISFSLQLCPDTMTRSESFEGQSFHPPPRFVKVMDEFRSPHSMLDRHKFAVNTNADSPSLPIASTRIFGMLSGPPHSTEDATPCWATISVSTNAHSLTDGLHVGGDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJC3</accession>
    <name>A0A1Y2BJC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_515359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJC3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJC3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJC3"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="298" mass="30585" checksum="E374EEA09F5B2BF5" modified="2017-08-30" version="1">MSTREAEINSAATAILEEMISDLILSTAISAHREIKRGLVLCGTCNTFCRSHNVLELSSSSASSSSLRVPSIEAGSSTSRSNSPQPPSAESRVAGYLVGPEKGTGGATGIGSGSGRMDGSGNVFFDCLVCSRPIASNRYAPHLSSCLGFNGGRRGAARSAANKARLGAHDRSSPSPYTGDSDGESTASRRKKNGLNGNGKRGKSPTKLGGLGKKSKTTSGTSTPIPSSRPALPPSKLGRTPTVSTASPVLAPSQTSTASRKTLPGIDVPIEIDADGDEYVPPIEVLDDDSSEGADDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJG9</accession>
    <name>A0A1Y2BJG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_503382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJG9"/>
    <dbReference type="InParanoid" id="A0A1Y2BJG9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="242" mass="27398" checksum="F604E954C8640DC3" modified="2017-08-30" version="1">MYLMLSPKVVQLCEPACNLGMFKRRKRNSDVLLIGERVCQECQEGRSRDSNFLDDQNRDETSAWREVPKEEGKGRREGKREGGVDQTQGSDGRVFDGVMKWPIMENTSMPRLSATINRGRRYLIPSRGEGSRELEDVWATIADSIPVTVTVYVKASRGGWAFNSPITGKRRTVEAYNLSRQEDQDRDRDRDIEDYKVECVQLGSKSARDSGIRSEAKTGLGDRAGKQLLEQWKHPVPGTTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJN1</accession>
    <name>A0A1Y2BJN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_515912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJN1"/>
    <dbReference type="FunCoup" id="A0A1Y2BJN1">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJN1"/>
    <dbReference type="InParanoid" id="A0A1Y2BJN1"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="445" mass="49803" checksum="B788062214330816" modified="2017-08-30" version="1">MSARIPMSRIYAGARISKTAKPSTRLLIPRRGYASTPKPDEPKRTSLASAAATGFVAGLLFVVGSRYTSSADAGTVKADGAPALEFVDTYGKPWHPAEAIEKDDPRNPMRIRMASWVKNLQDHIVTTIESLEASAPPNANETSPSTTSAPKFLRDAWIRPNASGEGSSCVLANGRIFEKAGVNVSIVQGMLSPGAQAQMRADHSSLPINRTEPLPYFATGLSIVIHPRNPHVPTVHLNYRYFEIADKDDPTKPVAWWFGGGSDLTPSYLVEEDAKHFHKTLKDAADRHHPNYWPKFKPWCDKYFYIPHRSEARGIGGFFFDDLTSSSEVHGDKQPSKEEIFEFIKDISGAFLPSYVPIVVRNRDKGWTEQQRRWQLIRRGRYVEFNLLYDRGTKFGLNIPGARVESILMSLPETARWEYCTELGQEQGTEEAKLLEVLKTPKDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJP8</accession>
    <name>A0A1Y2BJP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_515032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJP8"/>
    <dbReference type="FunCoup" id="A0A1Y2BJP8">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJP8"/>
    <dbReference type="InParanoid" id="A0A1Y2BJP8"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="213" mass="23167" checksum="73AFA1D7FEBB8A5A" modified="2017-08-30" version="1">MAEGSNYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSINVDSKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHATYENVTRWLKELRDHADQNIVIMLVGNKSDLKHLRAVPTDEAKSFATENGLSFIETSALDASNVEAAFQNILTEIYRIVSSKSLESSGDVIKPSGGETILVAPTADDGGAKQGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BK73</accession>
    <name>A0A1Y2BK73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BCR39DRAFT_462026</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BK73"/>
    <dbReference type="FunCoup" id="A0A1Y2BK73">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BK73"/>
    <dbReference type="InParanoid" id="A0A1Y2BK73"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="201"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="414"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORY35017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="594" mass="64644" checksum="5BBBF3B59D3879D9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLK1</accession>
    <name>A0A1Y2BLK1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-lactaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_511245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLK1"/>
    <dbReference type="FunCoup" id="A0A1Y2BLK1">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLK1"/>
    <dbReference type="InParanoid" id="A0A1Y2BLK1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="345" mass="37686" checksum="CBBF3D518B5BD295" modified="2017-08-30" version="1">MPAIQKGAYVLVTGASGFIASHTVREFLREGFRVRGTVRSQGKGEYLQKLFAKDGPFDFVLVDDITKDGVFDEAVKGVDAVAHLASPFYTTGVKDPQELIGPAVKGTTGILKSIQKNNPQVKRVVITSSVASIMSLASRKAPVRYTEKDWNEDAVKHVEENGLKSQGGFAYQASKTLAEKALWKFIEDEKPSWDAVAINPPYVLGDVIHECEKPEKLNTSVASFYEWAAGQKKEEDTASQLGNWANVHNVAYAHVKALTVPEASGGRFIVSSGPLAGQAFCDILHSKYPELKNVPVGKPGTSDDINKDANVFVGDHAAKVLGVKYESLEQTVVEMVESFKERKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLQ3</accession>
    <name>A0A1Y2BLQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_28811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLQ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLQ3"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="693"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="738" mass="81991" checksum="357D3A6BC4B955E6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM12</accession>
    <name>A0A1Y2BM12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_596398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM12"/>
    <dbReference type="InParanoid" id="A0A1Y2BM12"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="430" mass="46678" checksum="7394FAE8D48FF410" modified="2017-08-30" version="1">MSSSSSDQPSLELIQICFRSLQDDQSPQQFLQTLRVISDLNSAFPSTISTVPSTTLKELVGDQPIQYTTLDAIWLSYFRRTSQKSEHNPLDQWVKCLETINNVRDEALSDLNRLIDGKDKRRARKKRVTAQWLLAVQSGSQACLETSLYKHRLQGGPVSALEEQLARIALDPVTKDYRTKGLYTSRLQELLVDDGVIVTPQDFIDSLAPELARHDFRALAKCLTTDFPHVYNATLELLKKTQSGQSTLASSAQTAQATTDLRASTADPGTHTTVEASATSGGGPLQRNTVFDDGTTPSASSAPEVTDLPESVDAKESVTSGSADSTDTPELKCTSSTASTQVFFSLKSGPSSQYLGVDWPKVEASDPHGDYNPNPKQLSPRASRRHLVSSRSSGVMTRPSSPVGSSTDPELSTASTRPRASSVPDSKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMA8</accession>
    <name>A0A1Y2BMA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cation efflux family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_592170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMA8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMA8"/>
    <dbReference type="InParanoid" id="A0A1Y2BMA8"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="403"/>
            <end position="421"/>
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            <end position="459"/>
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            <begin position="495"/>
            <end position="513"/>
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            <end position="669"/>
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            <end position="20"/>
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            <begin position="126"/>
            <end position="137"/>
        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY35889.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="81878" checksum="5A53638AEE2629D7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ACN7</accession>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
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                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
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                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
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                <person name="Spatafora J.W."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">68-887.2</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
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</entry>
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                <person name="Labutti K."/>
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                <person name="Salamov A."/>
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                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
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                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
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    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="OrthoDB" id="6275295at2759"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ORY21007.1"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFV2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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                <person name="Haridas S."/>
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                <person name="Salamov A."/>
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                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
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                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y2AFV2"/>
    <dbReference type="OrthoDB" id="2594372at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
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        </location>
    </feature>
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            <begin position="515"/>
            <end position="597"/>
        </location>
    </feature>
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            <begin position="136"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="597" mass="64792" checksum="9BFC17D01EB9CF4A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFW8</accession>
    <name>A0A1Y2AFW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000113">
        <property type="protein sequence ID" value="ORY21334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFW8"/>
    <dbReference type="InParanoid" id="A0A1Y2AFW8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="610" mass="66949" checksum="91F1214B802F0737" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGG7</accession>
    <name>A0A1Y2AGG7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxyphosphonoenolpyruvate phosphonomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_554276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000119">
        <property type="protein sequence ID" value="ORY21045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGG7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGG7"/>
    <dbReference type="InParanoid" id="A0A1Y2AGG7"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF5">
        <property type="entry name" value="CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="310" mass="34177" checksum="2513D8109B2E58B4" modified="2017-08-30" version="1">MFDKRPRTTFRQLMSAGQVFTPCVWDCYSAKAAEMAGFTAILLSGASLGFSMSGVPDMGLHNQEELIWATDRIADYSPLPLIIDADDCFGDVAQAYRTCRRLAKAGAAAILLEDTPNERGYARFGRAMEAATLAGKLDGNIDHPVVPQDLWLAKIKAALDACAGTDCVVIARTESKLEKGLDDAIERCVRAQALGAEMTYVHGLRTLDECKKVAKALPGWKMFGDVATVDGKPFVELEDIAALGFNLVTMHYLEKGSMWGMMDFGKEVFRTSSTRYADEHTMGGRSKEEQRQLLERDIGWLAAEDEWKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHA2</accession>
    <name>A0A1Y2AHA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_552832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000103">
        <property type="protein sequence ID" value="ORY21862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHA2"/>
    <dbReference type="FunCoup" id="A0A1Y2AHA2">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AHA2"/>
    <dbReference type="InParanoid" id="A0A1Y2AHA2"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="199" mass="21992" checksum="6DB77590C79E9EEE" modified="2017-08-30" version="1" fragment="single">MSSSNFVVVNSPEHFKSVLSEDLNRVSCLNFWAPWAEPCAAFNKAFEDKAAKFPSVLFLQIEAESLADISESFDIEAVPSFLLLRGHTLLARHSGSDTNLLQSLLEQYSGAPSSSTTAPQATTNATPQAPAAPAPRQRTEEEITARCHELMNKHKVMLFMKGNPSAPKCGFSRQIVGLLREKGVEFAWFDIFSDEDVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIE8</accession>
    <name>A0A1Y2AIE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_551926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000096">
        <property type="protein sequence ID" value="ORY22244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIE8"/>
    <dbReference type="InParanoid" id="A0A1Y2AIE8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="483" mass="52958" checksum="E4802E7566D227B5" modified="2017-08-30" version="1">MQSGVLFELESNLAQSAEVDSRESDSSTATNAPALTPIVLHQELPDIDSDPDSSTYLGDDFSFIRQLPLDVLPASAESSRVELPYSIQDLYAENVSLSADLTAARESIARLELENDRLRADLEEDKRSSTEIIEKLRSQLNDMEASMSTVRAMHGSKVESMRLQIQELEDQAKTRTATIGQLSTDGAILRQEVERMQSKEKHLVQERDASLNREASALKRLSVAGQRLDSAERDVRLASASQLLSWQQCNRLLTLVVLAMPLKQQGNDSQEQIGTPKELAVIIRSVMEGLSRGGKLEDISSVWGALRRRMTQGDVANSVRSPLFIISTVHQLLDSESEPLGADSQLRHTLSQIKDDLFAIAQEQMARGLKLRIMNVSAPLAREQLPITLEELLRNIRQSWTSADLEREGCILLEAAFGAIGEAGLEVIERASNSAQTSSQEQNYRTLLRALASKSPTCKSSLTGPSIHSCAAGQGASVLQVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIS7</accession>
    <name>A0A1Y2AIS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_551583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000093">
        <property type="protein sequence ID" value="ORY22436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIS7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AIS7"/>
    <dbReference type="InParanoid" id="A0A1Y2AIS7"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1267" mass="136255" checksum="DAACF63D6185896C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJK3</accession>
    <name>A0A1Y2AJK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJK3"/>
    <dbReference type="InParanoid" id="A0A1Y2AJK3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="290" mass="32135" checksum="CCE5EFB0918944DA" modified="2017-08-30" version="1">MAPLPIPKIYPVPRRLIIKAFDSGFDGSAQPPPPTFSKSNLPSTISSFSASIFPIPSSSSSPYEFSSRSTPSLPPTPPNTPTDSFTAFRPGLVDRDITTRRKRVRFEDDPDDDKTADYEGAHWLDSNQPLSYISSENCWRRIASSLRRLEEDPRTWAPGPGVTAAVDTIQQLVMTRRFEVTHDTTLRAPFDTTWSIRGTALSNTLKVLGERLSPNSHDHPGKTVNTWNGSNSAALRLMATEAREEFNKWMHDTSIVSRWNEGVGDTGNSHGDEHGYTSNRESSLLESSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALJ8</accession>
    <name>A0A1Y2ALJ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA processing factor 3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_590969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALJ8"/>
    <dbReference type="FunCoup" id="A0A1Y2ALJ8">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALJ8"/>
    <dbReference type="InParanoid" id="A0A1Y2ALJ8"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="224"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="450"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY23431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="615" mass="67525" checksum="4EF488F04F07E5E1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM37</accession>
    <name>A0A1Y2AM37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_548981</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM37"/>
    <dbReference type="STRING" id="71784.A0A1Y2AM37"/>
    <dbReference type="InParanoid" id="A0A1Y2AM37"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15585">
        <property type="entry name" value="PHD_ING3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042020">
        <property type="entry name" value="ING3_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="374"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY23621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="440" mass="47754" checksum="0E4E413935EF22F5" modified="2017-08-30" version="1">MPPKASVAHQPSASPPPPPGSSEAQDLLVIQDFMDTLDQIPPELTRVHSDLNELGAVLYSTLQNLEVKLNTLINWIQDPSIGVERRFQLLQEIAEEAARYKLGGDDKIRVAGGACDGIMAHQRHISNLLTASTLLQPGPPSPYTQSLTLANLPPTSNTRRGAMRANNSPFTGRGYASTGAGGALGLEGREHPTPTKKKKSRVQQLGAGRDDDEVSSVGGDRKKPPVKKKRATNRAPSPTESTGSGYGQASKPNLPMTDRQRAAAEAKLKAKERKADDDSEEEEEGRRSGQAARVSPSAESNVREGNGDGRESRVSRVRAGVKRGRADDEDEDDEEDDGEEDVKPQAKRTTSNKKTTIQADELPIEDTAVGDGERLYCTCQAVSYGEMIGCDNEDCDIEWFHLACLGLDKTPEGTWYCPYCVDKFSKVPKKKAPPKAKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMC4</accession>
    <name>A0A1Y2AMC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine dehydratase alpha chain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_500957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMC4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMC4"/>
    <dbReference type="InParanoid" id="A0A1Y2AMC4"/>
    <dbReference type="OrthoDB" id="192663at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000001">
        <property type="entry name" value="L-serine ammonia-lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine dehydratase beta chain" evidence="11">
        <location>
            <begin position="55"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Serine dehydratase-like alpha subunit" evidence="10">
        <location>
            <begin position="287"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY23367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="606" mass="64507" checksum="F7C31C1128225552" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMS9</accession>
    <name>A0A1Y2AMS9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="9">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="9">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAN2</name>
        <name evidence="12" type="ORF">BCR39DRAFT_548593</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="9"/>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMS9"/>
    <dbReference type="FunCoup" id="A0A1Y2AMS9">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AMS9"/>
    <dbReference type="InParanoid" id="A0A1Y2AMS9"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="512"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="908"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="910"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1017"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1070"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY23812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1117" mass="123481" checksum="E1E370DFDFB92E14" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP73</accession>
    <name>A0A1Y2AP73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_547034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP73"/>
    <dbReference type="FunCoup" id="A0A1Y2AP73">
        <property type="interactions" value="725"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AP73"/>
    <dbReference type="InParanoid" id="A0A1Y2AP73"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY24388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="558" mass="60193" checksum="691E5297006EFEF2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP90</accession>
    <name>A0A1Y2AP90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_324992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP90"/>
    <dbReference type="FunCoup" id="A0A1Y2AP90">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AP90"/>
    <dbReference type="InParanoid" id="A0A1Y2AP90"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="4">
        <location>
            <begin position="116"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY24399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="227" mass="24844" checksum="7FACF9CE6170D617" modified="2017-08-30" version="1">MYMTYDHRVARAEHPEPAPPTPMTPYRANAAVVLRSPPPNPRTITPDLIPELESIVIHIMVKEAVVSKHNLLSGIMALRALSGEASNGGNRRGASGVQVIRAKVGAASFRLRAGMPIAAKVEIKGEAMYDFVQTLVDFVIPRIRDYPGIPIPADGKSTKSPSVVGGVFQFGLPPSAMALFPQIEANIDAYPRMHGMHLYFKTNQKGPRAETTARVLMSAFRLPFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APE4</accession>
    <name>A0A1Y2APE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_472377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APE4"/>
    <dbReference type="FunCoup" id="A0A1Y2APE4">
        <property type="interactions" value="1054"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2APE4"/>
    <dbReference type="InParanoid" id="A0A1Y2APE4"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03775">
        <property type="entry name" value="MATH_Ubp21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000215">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000236">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="50"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="210"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1114" mass="127775" checksum="74672B2622EEED7F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQ19</accession>
    <name>A0A1Y2AQ19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_561485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQ19"/>
    <dbReference type="InParanoid" id="A0A1Y2AQ19"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012214841" evidence="2">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY24586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="129" mass="14145" checksum="DF73E5D1A067B0E3" modified="2017-08-30" version="1">MFKQLVVALLASSAALASPVPATEVKVEKRSSSGLATYFEVGLGACGWTNANEDLIVAINSDQYDNGDHCGKWLTIKNKANGKTVEAYAADECPSCDWGSLDLSPQVFGKLTDWDYDEGEFDITWWWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQK9</accession>
    <name>A0A1Y2AQK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_581718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQK9"/>
    <dbReference type="InParanoid" id="A0A1Y2AQK9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="260" mass="28483" checksum="8BDDC87F255A536B" modified="2017-08-30" version="1">MVMSEASPSVKSEDSPSVSRDTSPSRDLIPGSHSLYSGRDKLADGGYDDGDAGFYYEDNSGNVTAKRGKSPSGVTIPWPGSLYSGSDDSAGKRSSNALVPRRTRQSGPKHESSRMSRVRSKRDEASAAMSMGTSEEKEPFDGVCNSSTESMMTCDSDGQQASDETEERFGGWDYDARQRSSQGQSKGMNCRTSTTESDHPEINSEEMEDERGEQERQEGQERQEGQEGQEGQETTDEEEDEHFVSSMLLERPDANAYDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARD9</accession>
    <name>A0A1Y2ARD9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase C13 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_545941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARD9"/>
    <dbReference type="FunCoup" id="A0A1Y2ARD9">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARD9"/>
    <dbReference type="InParanoid" id="A0A1Y2ARD9"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000016">
        <property type="entry name" value="GPI-anchor transamidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027537257" evidence="6">
        <location>
            <begin position="27"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="411" mass="45774" checksum="99F047FA48FF3F6F" modified="2017-08-30" version="1">MQPRPSWLSSALLLSALLALLTTASALSHEVEKQVTDLFTSNGTVPARHTNNWAVLVCSSRYWFNYRHMANTLAMYRTLKRLGMPDSNIILMLADDVACNARNSFPATVYANSGRQMDLYGDWVEVDYRGYEVTVESFLRLLTGRQPAYTPPNKRLLTDASSNVFIYMTGHGGDEFLKFQDNEEISAFDLADAIEQMSEKRRFNKLLYVVDTCQANTMYSKIYSPNVISSGSSAIGENSYSHHNDLDIGVAVIDSYTHYILQYLETTSKTSKATLQDFFNTYDPARIHSHPGISTELSSVAPEEILVTDFFGGVASIEIMSRDKELPIFARGLTSWKEVRRVKSIGGDQREAWQARRPLGSAVAAGGWDRPLSEDKDIWESLRGVGTAVALGVAIVAWSVSGSESRKNKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARN1</accession>
    <name>A0A1Y2ARN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_544586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARN1"/>
    <dbReference type="InParanoid" id="A0A1Y2ARN1"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000700">
        <property type="entry name" value="Solute carrier family 45, member 1/2/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="708" mass="77100" checksum="515F198165DAE5EC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASA8</accession>
    <name>A0A1Y2ASA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_544074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASA8"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASA8"/>
    <dbReference type="InParanoid" id="A0A1Y2ASA8"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="76221" checksum="07558BC5A631FB0D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASR7</accession>
    <name>A0A1Y2ASR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_285917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASR7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASR7"/>
    <dbReference type="InParanoid" id="A0A1Y2ASR7"/>
    <dbReference type="OrthoDB" id="2563380at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="58854" checksum="6333B11C4B5346DF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASS3</accession>
    <name>A0A1Y2ASS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_471209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASS3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASS3"/>
    <dbReference type="InParanoid" id="A0A1Y2ASS3"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48168" checksum="08A6418E93C28DF2" modified="2017-08-30" version="1">MTPSHSPAGRRRSSTTHFLGRLLPPRSTLLLVLVSIIILTVFHIHQPSNLQTLRQRTPRSLQHAFSTSSSAAAAAEPSPWIPLQSVLDRIDADIASSAASYDSALYYRELGLKLGSTTTEEYIAELSETYNEFFSPASPKLLDDVLSRLSHLPRAQTVSLPKQIYTTDLRSPDQFPEQFKSWSEKNPDWETLFVEDEAIEGWVSETVGEDAGVLQELHALRAGRGVLRADLFSRYLVLLLNGGVYTDTDTACVRPLSQWAVSPDRPTTHPLAQSLPTLLELADESLSTQEDSPALIVALEADAPDLNTDWRGESFVRGIQVVQWTIQAKRAHPILLDVLGRGLREAKRVREAEERGEEDLEWTGPGAFTDAVMRYLLVHHGVHPGQLSGLRRPVRYGDIVIMPVHSFRADASEGDQGEDRVVWHGFFGRWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASU7</accession>
    <name>A0A1Y2ASU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASU7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASU7"/>
    <dbReference type="InParanoid" id="A0A1Y2ASU7"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="85" mass="9694" checksum="507EB510F0DD4153" modified="2017-08-30" version="1">MSGQILWGKWALFSTATVTPTEEQLYDRLAPDLKRKVDELRRQREASSPLKERLTDPNSQDQIVWADSLGNNNTNKLPPGTSRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASY5</accession>
    <name>A0A1Y2ASY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar protein 14 C-terminal Fig4p binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_543718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASY5"/>
    <dbReference type="FunCoup" id="A0A1Y2ASY5">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASY5"/>
    <dbReference type="InParanoid" id="A0A1Y2ASY5"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="683"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="914"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="920"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1045" mass="112916" checksum="30F5E590E0CD9EA8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT38</accession>
    <name>A0A1Y2AT38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_544502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT38"/>
    <dbReference type="FunCoup" id="A0A1Y2AT38">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AT38"/>
    <dbReference type="InParanoid" id="A0A1Y2AT38"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="318" mass="33601" checksum="B183C680EB1444C1" modified="2017-08-30" version="1">MSSSRRSDGRSDTSIRELQIQLGRLDRADGSARFGFGATAALASFSGPIEVRPREEQPTRATFEITHRPLEGVAATPSRALITTLEAVLAPLVRTDQYPRSLLQLVVQSLSPSPQAPLSTSYSATSTSSSSTSHTWPPPDTSSEDEDDDGYIVQETDSAPMGGTTFASRAAAINASTLALLDAGSISMRGVPVAVSLALVPLPPKQVISAVNGDGSGGGGDGDGRIVVDPSLEEESRSRARFGFGWAFGEGLAGARQDASDEMDVDEQSSEELVWSEAEGKFNKSEYEQALALSKAASRHILGEIRQTLTEHFASTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT54</accession>
    <name>A0A1Y2AT54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_471137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT54"/>
    <dbReference type="FunCoup" id="A0A1Y2AT54">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AT54"/>
    <dbReference type="InParanoid" id="A0A1Y2AT54"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="63029" checksum="48A9F5773C6FFBBD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATD9</accession>
    <name>A0A1Y2ATD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_280072</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATD9"/>
    <dbReference type="FunCoup" id="A0A1Y2ATD9">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATD9"/>
    <dbReference type="InParanoid" id="A0A1Y2ATD9"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="108"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="298"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="525"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY25734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="559" mass="61781" checksum="562B93046D29C42F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUU0</accession>
    <name>A0A1Y2AUU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_258419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUU0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUU0"/>
    <dbReference type="InParanoid" id="A0A1Y2AUU0"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="164"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY26319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="398" mass="44278" checksum="6E949E4599D91A6D" modified="2017-08-30" version="1">MSSPKPGIIVYTTPPLHPLPASDAESIYLVALFQLVCPGRWGLSTGDWSVNGGKLPYVTHLDRLVTTSQLKSLPSLEDPDERLSATDRGECLCWKAYIEGQLIDLVNHTLYSLPPNYPTLLGPALSTDLSWPQSSYIPQRIRGLIKERLQHVGLWGVGGLNTGDAWEEDQKRQNEAFVAGPGGTLAPRAWSGWRAGRELEERRRRFGEEERAKAVLDPLERRLGSGMYFFGDSPTTVDLFLFSQLALLLAPSWPNQLLPTLLKFSYPALVAHHDRVLSLLFGAVGWSHTALARLPAPPRKTIGIWDEVQSWFRASGAKEAEKSKQSEKDKSLRKGRWAWYATAIGSMAVYLIWSGLVTVEYVGLGGAEQDDEVEEDEAEELQEVIVLEVVDDEDDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVK0</accession>
    <name>A0A1Y2AVK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_470533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVK0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVK0"/>
    <dbReference type="InParanoid" id="A0A1Y2AVK0"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="355"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY26257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="582" mass="63473" checksum="E4B5C79D7D94891B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVM3</accession>
    <name>A0A1Y2AVM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_541446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVM3"/>
    <dbReference type="FunCoup" id="A0A1Y2AVM3">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVM3"/>
    <dbReference type="InParanoid" id="A0A1Y2AVM3"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="282" mass="30583" checksum="DF44E47455057BFE" modified="2017-08-30" version="1">MSDDPMADFLAREKAALGDDADLFASGSAPSQPSGIDSFPDFNTSAPSAPQSAVEPAPRGIDAFPALDSPDIGGTDVRVTGVAGTGEDADREHFESAFPDLTSEVPFEAPSKPVFNALSPQPYGQSPYPPTAAPQPSRSILPPPAFSNILPAAEEETEPIREWREKQAAEIKRRDEQDKAKRDEMRGKAEKAIDSFYEDYNKVKERNIRENKEHEAAFLEKLSEGIAKGTAWERITELISLENSQSKTIRPSVPGGSDLARMKEILLALRREGDKAPGAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVM5</accession>
    <name>A0A1Y2AVM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Carnitine/acyl carnitine carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_541027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVM5"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVM5"/>
    <dbReference type="InParanoid" id="A0A1Y2AVM5"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="118"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="225"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY26504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="315" mass="32655" checksum="DEDF04A2E059E249" modified="2017-08-30" version="1">MSDDASELEALQRSSAKQTIDPIKSFLSGGAGGIACVLVGHPFDLTKTRLQTASPGTYTGAVDVVRKTIAADGIKGMYRGITPPLVGVTPIFAISFWGYDMGKRIVYAATPNRKVQALSIPEIALAGGLSAVPATLVAGPAERIKVLLQVQGQGGNTAYSGPVDVLRKLYAEGGLRSIFRGTVATLARDGPGSAVYFATYEVLKKRLSKPPGTLPSGETAPAPPLSLGAVMFAGGSAGVAMWALAIPPDTIKSRLQSAPHGTYSGFMDCARKLITADGVTALWKGFGPAMARAFPANAATFVGVELSLSAMDKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW74</accession>
    <name>A0A1Y2AW74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_540527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW74"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW74"/>
    <dbReference type="InParanoid" id="A0A1Y2AW74"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY26704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="270" mass="29599" checksum="47A84A74C41C7BAF" modified="2017-08-30" version="1">MSDLASRLEPFLLLARSTKGASAAKVIHDAVSATGVYVFAELLELPNIKQLSGDPNHSKQFNLLQLFAYGTLKDYTDDTDRYPPLTTQQLAKLKHLTLVSLALQHRSLAYAQLSTALQITSVRELEDLIIDVIYAGLLRGKMHHHEKVLHVDWVAGRDVREADLSTIKTGLENWCRTAQTLLDALDSQIDHTLAVTAQKQEDETVYRQKRDNDFAAVVAAMRSEQRPGRERRAAEDLLGITRGDGGSRGGGSGGGLGLGGRREGALFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWB9</accession>
    <name>A0A1Y2AWB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_506629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWB9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWB9"/>
    <dbReference type="InParanoid" id="A0A1Y2AWB9"/>
    <dbReference type="OrthoDB" id="2575478at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="545" mass="59259" checksum="1AFB7CC94A7A5253" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYN5</accession>
    <name>A0A1Y2AYN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_537984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYN5"/>
    <dbReference type="InParanoid" id="A0A1Y2AYN5"/>
    <dbReference type="OrthoDB" id="2564489at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="335" mass="37362" checksum="5DD3226D3793B6C0" modified="2017-08-30" version="1">MSLHRSTSRASYQLTSTSPTKRLSSQPNNFGVGTTSATTLPSDMQDTCHDTLLQLEQEIADLRRELGTAEDLLARSQKDNEQKHEQNEHYKSYVKTLEKLLDDTHTPSWREDINVHHPQNIATTAFFASTPLPKPSPANALRQTASFTLSARRSVRATQLHRASAMDFGALKQIQELKEIPDRDETPTAAMRRLEGRQEVLMDTTGKEASMQTANAGHVKRVLSSSLYTTPNASTRVDIPVDRSAPATTALRPEHVERLISLLSTVPSDFTSRSAADQRRSSEAADVERDRAMLTAERRGMLEMIEAFESRLIDKSQGLNDLLEQVSRYCGEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYS2</accession>
    <name>A0A1Y2AYS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_537551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYS2"/>
    <dbReference type="InParanoid" id="A0A1Y2AYS2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="328" mass="35877" checksum="976101D406ACDCD6" modified="2017-08-30" version="1">MTTASSAPSDSPERTASIGPSLHLTMMSQSETDSSFQSILSVAHSYKEPILHHSSSPPPPGSRKAFTSPTLLAPQPLGQIDDPLGLLELRRPFNSATEANEHVQDRVPSERTDQSYFPTALLPAFPVSDPDRLTSIAILSTTIWKRLAPVLPTADKVKGTHRPGTSPSAIGFGFGKASILPPIWTYHRMVLTHFKMHDVMPSQSIRGSAKHQRQLSTQTVAHLHLFTMQSYPSAMPSRPSTSSSIPQFGSVNKKRPGTSQGLQSTLEKIESERRMIDGTTTVGIWDEATGPDLKRKNVLRIGFGSEQTGKQTWYCSFADTWVCVCNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYU8</accession>
    <name>A0A1Y2AYU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_496925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYU8"/>
    <dbReference type="InParanoid" id="A0A1Y2AYU8"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="550" mass="61644" checksum="D19AA9942EAF1F4E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYV9</accession>
    <name>A0A1Y2AYV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_565606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYV9"/>
    <dbReference type="FunCoup" id="A0A1Y2AYV9">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYV9"/>
    <dbReference type="InParanoid" id="A0A1Y2AYV9"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY27759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="423" mass="46790" checksum="B1607C893B6B89B1" modified="2017-08-30" version="1">MAKGKVILAYSGGLDTSCILLWLIDEGYEVIAYMADVGQEEDFEAARTKALKCGASGFFLADLKREFVEELIYPAVQCNAIYENVYLLGTSLARPVIARGMIEVAEQQGCDFVSHGCTGKGNDQVRFELAFYGLAPGIKVIAPWRLPEFYERFAGRSALLNYAAEKGIPVTQTAAKPWSTDENLFHISYEAGILEDPNQTPPDDMWKLTTSPLKAPETPEQVQIEFTQGLPTKVTFPADGKTVTDAVEVFLTLNALARKHGIGRIDIVENRFIGVKSRGCYESPAATILRVAHMDLEGMTLDRNVRALRDQFITTQLSQILYNGFFFSPEREFITAAIPASQKTVNGIVRLKCYKGNVIVEGRDSDEGLYDAKFSSMDEMGGFEPTSTTGFIDISSIRIKAWGRANIKRGQGGVTPKDVYHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ51</accession>
    <name>A0A1Y2AZ51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_536922</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Plays a central role in virulence and antifungal drug action.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000036">
        <property type="protein sequence ID" value="ORY27744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ51"/>
    <dbReference type="FunCoup" id="A0A1Y2AZ51">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZ51"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ51"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY27744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="175" mass="19564" checksum="0D51EFA85C4FF1CC" modified="2017-08-30" version="1">MGQAESSVFSSLEKNSNFSAPELLRLKKRFMKLDKDGSGSIDKDEFLQIPQIANNPLAHRMIAIFDEDGSGTVDFQEFVGGLSAFSSKGGRDEKLHFAFKVYDIDRDGYISNGELYLVLKQMVGNNLKDQQLQQIVDKTIMEADKDGDGKLSFEEFTGMVASTDIVKQMTLEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZ91</accession>
    <name>A0A1Y2AZ91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_536580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZ91"/>
    <dbReference type="InParanoid" id="A0A1Y2AZ91"/>
    <dbReference type="OrthoDB" id="5420221at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42769" checksum="B1C56C61A83538F1" modified="2017-08-30" version="1">MQVDLLPPIPHHQVPNSALPEAISLQVQLLNVQVEEHLEAQRSRIIRVHRGIDRTGGIDMATTIFPTGLTNQLMRLNSVYIWSAAVQIAYHLPAVLRASGDERFRAVNTMAGAVSAGLLIGGASRALASRITKVVVAQAKTLMGNHSGTALESVCAPFIHNALHNTAFTGVRHGLEAAWSALQACLAYMRGGLSDHAEAAQHRYQAGQAFGGRAAVRVIFNSLAAGSISFVCGPLTFASVAPIGISSILISRISENIVDYVLDTMRPRIYRWRTWAVSFFRDVRPKVWHSTDPIAQHILENVITDQLSCPISHQLIVEPIRSKITGQIYEKRHIQYWVEEHGSDPMAPRTSANWSKHFEVAADVVYWLNMYKQLLGLEQRPEEEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZC9</accession>
    <name>A0A1Y2AZC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Streptomycin biosynthesis protein StrI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_536807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZC9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZC9"/>
    <dbReference type="InParanoid" id="A0A1Y2AZC9"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="176"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY27922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51197" checksum="FEE9CAC2E26F8F63" modified="2017-08-30" version="1">MSLTSVRSPIKPALPLTHSLTQPKMTRNDDHVVSNGPMKAIIVGAGMRGRVYSNYALQYPELIKVVAVADPSRFRRRTMAKTHGIQEDMMFERWEDTMTLGKVADAVIIGLQDALHAAAVAAFSRRGYHILCEKPMATTVADCVAMTRDVNSEPMKGKVFAIGHVMRYSPYNEAIRKVIDSGALGDIVDVQHTEPVGNQHFAHSFVRGSWGNEKQSTFALMSKCCHDLDIVSFYMSGRTPTRVHSFGSLFLFDQARKPKQAGTATRCFDCQYESQCTWSAKKIYLEKPDGDLDHWMVSAVVDAEVMDIETVADALRTSQYGQCVYEAGNDVVDHQTVTLEYEGGATASIVMSAFSEAECQRSTRIAGTKGELIGDMESFTVFDFLTREKTVYKPQALDDSHGGGDAGLSRAFFEAVAKGDQTVLGVTSQDVLHSHLIVFAAEQSRKTGSTVDFRDFKQQALQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZX8</accession>
    <name>A0A1Y2AZX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_535720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZX8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZX8"/>
    <dbReference type="InParanoid" id="A0A1Y2AZX8"/>
    <dbReference type="OrthoDB" id="9980836at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="146" mass="16314" checksum="8BA5F480E1A05800" modified="2017-08-30" version="1">MSSKELLEAFLSTTTDHIIPLTAQGVASGCKVFGAAILRKSDRSVVVAATNHETASPLLHGEINCIQQFWGIPKETRPDPKDCLFFATHEPCSLCLSGITWSGFDNHYFLFTYEDTRDAFDIPYDIQILEAVSYLTDPFRLLLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B092</accession>
    <name>A0A1Y2B092_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="16">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BCR39DRAFT_496331</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="16"/>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B092"/>
    <dbReference type="FunCoup" id="A0A1Y2B092">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B092"/>
    <dbReference type="InParanoid" id="A0A1Y2B092"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000005">
        <property type="entry name" value="crossover junction endonuclease MUS81 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="18">
        <location>
            <begin position="483"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="361"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORY28258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="789" mass="88011" checksum="E4ADE72AF1CD6ECD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0C8</accession>
    <name>A0A1Y2B0C8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP/chorismate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_588878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0C8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0C8"/>
    <dbReference type="InParanoid" id="A0A1Y2B0C8"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF12">
        <property type="entry name" value="TRANSLATION INITIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="118" mass="12505" checksum="7625A4EDE34869BF" modified="2017-08-30" version="1">MSREIISSEEFPLKPHNCAAVKVPGLVFCSGQTATGPIAEATTTSLSNLKKVLELSGSSLEKVVKYNILLADMGQYFEMNKAFVAFLPSPCPARTCIQAGKLPGGDATVIEIECIAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0F4</accession>
    <name>A0A1Y2B0F4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_559617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0F4"/>
    <dbReference type="InParanoid" id="A0A1Y2B0F4"/>
    <dbReference type="OrthoDB" id="2576041at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35413" checksum="F0FEA933434387EF" modified="2017-08-30" version="1">MSTTQTGGSGTDKFSDDSKEAVGEDGVAQPVQQASSKKQRRETFDKYKPPWRVMFLEVLALLLLMLFTFLPPNSSGGVSAIAQVQSDGEAVGVLRSCTGSACDSWMAGATSPSSSSSSSSSTATTRSLEARAASQISSIINLSTFYLTTGLATLAAFYLLLYTFLFTLYRKVRKAPIRSEDNPPDTKLGWEQGLKRLAYRLCRCFLPINAIMSFAITLDCGIKSLKVRSGLKLSGTDGTGNGIGVIAAVFILLLVITLMELSTKDKRIHRFLHKTPGLCANFSCCSSGNRNAASDAERGESGENREDSRSRRIDGSRNRGRSGGRGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0F9</accession>
    <name>A0A1Y2B0F9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_559591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0F9"/>
    <dbReference type="InParanoid" id="A0A1Y2B0F9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="218" mass="24613" checksum="C61A444563D45878" modified="2017-08-30" version="1">MAGTAGTNRHEGPVGFYTKYQPEQVIEAFEHPPEELLTACMEVWRDGRWREEFPETVDERIKLWLEEEANVNKFPSPEDTRSIASSTTAHYHGVFEDVKIEYTIHVLADFISMVTLWKADQGSVRESSESQSENPSHSQSDNHSKDPYEDGVSFFAPHDHRALDYVFRNASADLVQSAKNMLLKGKRSPDANNPPRPFGGSNTSAKLSELSAERNADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0P6</accession>
    <name>A0A1Y2B0P6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_535402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0P6"/>
    <dbReference type="FunCoup" id="A0A1Y2B0P6">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0P6"/>
    <dbReference type="InParanoid" id="A0A1Y2B0P6"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44194" checksum="062ABDEA6F1CD597" modified="2017-08-30" version="1">MVKETEYYDLLGVSPEAGDDEIKKAYRKGALKNHPDKGGDPELFKELTHAYEVLSDRNKREVYDVHGKAGLEGGAGGMGGGMDPQDLFSQLFGGGGGFFGGGSSRPSGPRRGKDLVHRISVTLEDLYKGKVQKLALSKSVICKTCEGRGGKKGAVQTCTSCRGQGVKVMLRQLGPMMQQIQQPCNECEGTGEIMNPKDRCKNCNGKKTLSERKVLEVHIDKGMKSGQQIKFAGESDQAPGIQPGDVVIVLEEKPHPRFQRNGDNLFCEAEIDLLTALGGGEFAIEHLDERALHVTIVPGEIIKPGATKVISGQGMPSYRHHELGDLYVRINVKFPDSIPLDSIPLLENALPPRKEIQKFGKKVHVDEVTLEEPNDRQRRTVQNGDEMDEDDDERGGHGVQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Y5</accession>
    <name>A0A1Y2B0Y5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_204154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Y5"/>
    <dbReference type="FunCoup" id="A0A1Y2B0Y5">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0Y5"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Y5"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="357" mass="40266" checksum="59DE5BDD6E5B3F3D" modified="2017-08-30" version="1">MPHSHHSHSGQFCRHAKSTLREVVLEAIRQGFTTFGLSEHAPRYRLEDLFPEESDLSPVELIKAYDDFLLEASHLKTEFADSITLLIGIESESITPIDSVNLSSLLNNRSEIDYIVGSIHHVCGVSIDFDRSTWLRSVYTASRSTVSTTMISTSSGPRLPPSPDPPILQLESDFIPTQYELVPFLFSYFDAQYNLIIDHQPEVLGHIDLCLLFAPGVSWTSTDLQEIWPMVKKNVKAVVEYGGLFEANAAALRKGWETSYPGREILKLILQLGGRICLSDDSHGVSYVGLNYLRMKDYLVDMGVEEVWYLVPASQRQHDDQTVGRRGRVVARKFKGWAKHPFWDQLSQAQAQPKSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1Q5</accession>
    <name>A0A1Y2B1Q5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_534910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1Q5"/>
    <dbReference type="InParanoid" id="A0A1Y2B1Q5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="168" mass="17878" checksum="D57A34DCB79BE84F" modified="2017-08-30" version="1">MGGWSCLGVSVSISIPIKQSSPVANILQSKVVANLDESSLRRRRRSLQTTSDSDSQSTPRPQPHPTTSSSSSSSPNSSSSSRVRETSSPLTTSTSTSNTNSNTITRTLSTSSPDSPSMTSRYEAIRRRARMGPIINEPIPNHAVPVLGRQDLSTHLSTGGGGDAEEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2R8</accession>
    <name>A0A1Y2B2R8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L33-A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_533855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2R8"/>
    <dbReference type="FunCoup" id="A0A1Y2B2R8">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2R8"/>
    <dbReference type="InParanoid" id="A0A1Y2B2R8"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="106" mass="11884" checksum="03FA405D06989A10" modified="2017-08-30" version="1">MVATRLYTKGRILGHKRGKRNTRPNQSLVQIEGVDSAEAARSYLGKRVAYVYKAKREINGSKVRVIWGRVTRPHGTNGVVKSKFRVNLPAKVFGASCRIMLFPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2X2</accession>
    <name>A0A1Y2B2X2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_180071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2X2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2X2"/>
    <dbReference type="InParanoid" id="A0A1Y2B2X2"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012598538" evidence="2">
        <location>
            <begin position="33"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="148"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="306" mass="32329" checksum="AFA5A344683BCB14" modified="2017-08-30" version="1">MSGWHKSVRGNLPRMAKSVVAFFFVLSPLVQGGPIALRSGAHDRASSLSKRLAGPAPYWGIEELIGGDGCASEDLSQSSTGTSSTSPTATIAAIVRPSSATTPLSGIMAYAHPGGSDILNPTKIVGPPPVSSSHSLDEPSQTSTSTDQSADAWVKAHNAARNEYQAGNVTWNSDLVTIAQSNAQLCTGKHSNAGENIAAQSGSLTPQGSVDMWMSEAADYNWNDPAYSDATGHFTQVIWLATTEIGCFIAECPAGTVFGSQYGISYQGTCEYKSAGNVVSEWQIFEGVLYFCSRCRCRRIRSQCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4R2</accession>
    <name>A0A1Y2B4R2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_170813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4R2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4R2"/>
    <dbReference type="InParanoid" id="A0A1Y2B4R2"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001692">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.18, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="236" mass="26497" checksum="C1A10E2BE89E96CF" modified="2017-08-30" version="1">MYHLLKGLHEHLTRKDEYSVVIIGLDNAGKTTMLEQIKTLYNSTPGMPADKIGPTIGQNIGKISLPSTTLHFFDLGGQRDIRSIWPRYYDECHAVVFVLDAVDQARLSETWEVFDQVLNSPRLLNLPLLLLANKQDSPHCLSVSEIRESFDAWQRARPHQAEVDSNSSVPNSPGDVHSENGRHEHDGKWDDGGAKDERMASLDVMGVSALTGTGVRDAVNWLYIRVQNARKIEDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4Y0</accession>
    <name>A0A1Y2B4Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4Y0"/>
    <dbReference type="InParanoid" id="A0A1Y2B4Y0"/>
    <dbReference type="OrthoDB" id="2561286at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012146764" evidence="1">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="102" mass="10785" checksum="F1E290C429C5E738" modified="2017-08-30" version="1">MKLGYLTLAFSATTAATVLAFQPGEIPLNVAVRSTGGPCSGGDLKFFHKKDEIQHLKKKGIIPPIEIAEKRQSADDPLLKDYEPVAMSGGELKAFTGAGVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5Q0</accession>
    <name>A0A1Y2B5Q0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_574394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5Q0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5Q0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012078878" evidence="3">
        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY30016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="202" mass="22016" checksum="F429CF488844C4C7" modified="2017-08-30" version="1">MTSLIFLMILFISLFLTCQTFASPIAEPNPQPDSTSIVSLKNVYVILYFSRLCLYLYLYLDIYLYIDLYFYLYIYICICIKIYLYLYIYFQECQSGDSSPSSSSSSAILSAATTTETENNTYLSTVTGSISIPTPQTTFSADKIPTTTVSSSESTSASAASANGSTVVTEQQNTNDARGVWGCSAALAGWVGAAVALALYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B675</accession>
    <name>A0A1Y2B675_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_153273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B675"/>
    <dbReference type="STRING" id="71784.A0A1Y2B675"/>
    <dbReference type="InParanoid" id="A0A1Y2B675"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY30196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="729" mass="81864" checksum="24C44F884B05585A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B679</accession>
    <name>A0A1Y2B679_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 9">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_530117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 9"/>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B679"/>
    <dbReference type="FunCoup" id="A0A1Y2B679">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B679"/>
    <dbReference type="InParanoid" id="A0A1Y2B679"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY30234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="495" mass="55850" checksum="B16D5D21031753AE" modified="2017-08-30" version="1">MPLRASQLGHRSWRRALRQRAVTRRLNYSRNPFDLGDTRLLDELKDRGLVAAITHPELRIHLKKPSCVYSGVDPSASSLHVGNLLPLITLLHFQSYGHKALALIGGATGSIGDPSGRSTERPPLSPSQLQENVAGISAQVHRFFSRGNEYISERKFGKQRATDPGTLEVLNNYDWFKNMGFLEFLRVVGKTARVSVMLARDSVKSRMSTDQGISFTEFSYQLLQAYDFSILYRDHRCRVQVGGSDQWGNIVAGIEMIKRLQSDSGEGTEAAKGADGAFGLTIPLLTTSTGEKFGKSAGNAVWLDETRTPVSEFYQFFFRTADEDVERYLKLFTFLPFDVIAKHMKKHDSNTKSRWAQYILAQEVTELVHGRVALKRAQGSQDILYRRAPRDIKSTEVLDAFDGDHRLVRVSWKDIKGLPVTKIGTMFGLWKSRGEATKAVSKQRSVMITDRKIDDPRDEMIRGDLVDEHIAIIRWGVKHVLILYVDDAYPEESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6S3</accession>
    <name>A0A1Y2B6S3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_528588</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6S3"/>
    <dbReference type="FunCoup" id="A0A1Y2B6S3">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6S3"/>
    <dbReference type="InParanoid" id="A0A1Y2B6S3"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002899">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.83, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="370"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY30532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="775" mass="83536" checksum="0F5810A3F0760093" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7I6</accession>
    <name>A0A1Y2B7I6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_528419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7I6"/>
    <dbReference type="InParanoid" id="A0A1Y2B7I6"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY30802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="624" mass="69958" checksum="16118F267A6F8520" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B885</accession>
    <name>A0A1Y2B885_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_104326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B885"/>
    <dbReference type="STRING" id="71784.A0A1Y2B885"/>
    <dbReference type="InParanoid" id="A0A1Y2B885"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="284" mass="31860" checksum="696E30127F8E1018" modified="2017-08-30" version="1">MLPYDSLISDKAGSPSSSAPSSNRNPRACENCRTRRIRCCGGQPCSACINVGLTERCEMRAKARPKRLPRIATEASSSGAMAGWRFDHFVASVQRDIERWAEHRGPIISAALPDVFPLRHILSAARLANRHSPTPTVVHSYLQECLDLLPYVDYVDRTTLVDLFSRYQGDPWALAPPQKALVFAASCLGSFKQSINAERDHAEWYKRSIVELDGWSQASTESLIALHFLHMYTVQAGGILETRDVLKRMAVQVRGLSIHHWPSDERDAKLLFATIYKDRLVKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8C8</accession>
    <name>A0A1Y2B8C8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_528281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8C8"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8C8"/>
    <dbReference type="InParanoid" id="A0A1Y2B8C8"/>
    <dbReference type="OrthoDB" id="4838853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="334" mass="37287" checksum="BF946EB82FCD4874" modified="2017-08-30" version="1">MSLDPIGPCDSSPISPDTDLSKSSSLLPQPTGTSSVHHQQLPSLEYTLKTRKRSITIIWSLLIIDSVVLPISLYFALWYGTSLTPNNVFTVITAVIGIVSLIKYALRTWNLIKKSSACRPRDARRWSLDWFHWWLTFMWILIIIELVVGSIPTLPPIRVLALPGPTALFVWGTLILLMEVLRLANVRAPIRISSQPRGSIILPAIYPIIEDIVAVDGGGGTAYRDRLGKRYEASSVFRQMLGRLSLAWGIGAELAGAVTIALVFTIEKDAAYVVGWALPVIWAGVWAVLTIWYVKKELKRELNQWYSQSGEDTTGPDILELGENRIELQNRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B955</accession>
    <name>A0A1Y2B955_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_528022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B955"/>
    <dbReference type="InParanoid" id="A0A1Y2B955"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="224" mass="24812" checksum="AD816A6EB6C10664" modified="2017-08-30" version="1">MNFSLLLHSSSLCIEHPEADSRHAKSVLPFLLSIPPLPLWWQLVFPPLLGIWTCFLPQHITRNALIEGVAAVGRREPKFGSRVRIGGHENQSDGSISPASGHSCWEHGRGHRWLALEGLPMAVVSVVRFLARKSAWDGRGQLTPWLSRKALSRKRFDLALPVSSLLSKTVSVNTRNEVTNIAFSIRHGERLLLKACRCPTKTVAVHCPTKTVVKSSVPNQDNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAA9</accession>
    <name>A0A1Y2BAA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="10">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_587667</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAA9"/>
    <dbReference type="FunCoup" id="A0A1Y2BAA9">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAA9"/>
    <dbReference type="InParanoid" id="A0A1Y2BAA9"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="563"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="500"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY31015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="640" mass="68912" checksum="B894361EB5C8F50B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAI3</accession>
    <name>A0A1Y2BAI3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_525563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAI3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAI3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAI3"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF7">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="126"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="299" mass="29824" checksum="4CF9928988C71168" modified="2017-08-30" version="1">MQGKASGIWGKVRSTAQTAGQQAGTMLRDGSAMASSGGAGLMQSFSLPGESQKAAKILKGFLADPTRPASALNSIPKAVLLRAKGLAIFTILKAGFVFSGKAGSGLVIARLPDGSWSAPSCIATAGVGWGLQIGADLTEVVIVLNSDEAVKAFSRGGNVTIGGGVSAAAGPIGTGGSVNASIANPAPMFSYSRSKGLFAGLTLDGTILVERKDANRDFYGSSISSTDILTGRVPAPEIASAMYDIIEAAEGLDESDLPAEAYVPGAEGQPIPVGSTGATTGAPVPAPGTGNQTVFDAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAT3</accession>
    <name>A0A1Y2BAT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_564528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAT3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAT3"/>
    <dbReference type="InParanoid" id="A0A1Y2BAT3"/>
    <dbReference type="OrthoDB" id="2802356at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="359" mass="37424" checksum="6D268E48F739C655" modified="2017-08-30" version="1">MQYYNQPNMGGGGMGMDPRMMQGMMQPGMMGGMGGMGGAAAMGGTGALGGMGVVNPMYGQAYRQLGYDYQLPDSTYKPDASWGAWDLARARYSNDRLERPFFENIISTLTNYFSNRHLSEEAAREAHRRIYFRGEGEDAGNKTLGGAAAYQAYLIWDRDHYSAYHTYPSQENRERLVGLAVAELFALWDNVEPRSSRANVEEASQYAAATAKYLFDRVTGMMPGMGMGMGGMPMGGMGGMSGMGAMGGGMGGPMGGMGGGMGGMGGGMGVGMGGGMGGGMGGGMGGGMGGGMGGGMPMGPGGLANPMNEAQAAPGMHPYHYGTQSGVAYGNQPIDQMGHPTFPGGPGRSWYAYGQPRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAU5</accession>
    <name>A0A1Y2BAU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_86241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAU5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAU5"/>
    <dbReference type="InParanoid" id="A0A1Y2BAU5"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="389"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1060" mass="118266" checksum="BA749BB835EC3057" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB28</accession>
    <name>A0A1Y2BB28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_527316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB28"/>
    <dbReference type="STRING" id="71784.A0A1Y2BB28"/>
    <dbReference type="InParanoid" id="A0A1Y2BB28"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="545" mass="59910" checksum="717F565DED1F5157" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBD3</accession>
    <name>A0A1Y2BBD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_82627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBD3"/>
    <dbReference type="FunCoup" id="A0A1Y2BBD3">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBD3"/>
    <dbReference type="InParanoid" id="A0A1Y2BBD3"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="213"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY31860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="569" mass="62419" checksum="57239F2B0A02A003" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBD5</accession>
    <name>A0A1Y2BBD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">13 kDa ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_524254</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
            <location evidence="1 12">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBD5"/>
    <dbReference type="FunCoup" id="A0A1Y2BBD5">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBD5"/>
    <dbReference type="InParanoid" id="A0A1Y2BBD5"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="14" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="13">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY32133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="126" mass="13842" checksum="B343B46EB9DAB031" modified="2017-08-30" version="1">MSTPNPKAWPIADAQLTNKILDLIQQATHYKQLKKGANEATKTLNRGICEFIVLTADVEPIEIVLHLPLLCEDKNVPYVFLPSKTALGRACGVARPVIAASITTNEARELNSQIIAVKNEIEKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBE4</accession>
    <name>A0A1Y2BBE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_60461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBE4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBE4"/>
    <dbReference type="InParanoid" id="A0A1Y2BBE4"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012892279" evidence="2">
        <location>
            <begin position="20"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="45"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="577" mass="64384" checksum="D356CB07C5A00518" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBN6</accession>
    <name>A0A1Y2BBN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_523562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBN6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBN6"/>
    <dbReference type="InParanoid" id="A0A1Y2BBN6"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="184"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="277" mass="30765" checksum="50C1B7C604ADC5AB" modified="2017-08-30" version="1">MSFNDLERGESSQPLLRSGKADEDKAFTSIKDSVSIQIFKLQSNVQGIQRLVDKVGGAGDGPALRTSLHNLTEATRDMVKKSTDDVKNLASMPSGGQYSSRKPIQSKLSREFTSALSAFQRVQRLSAEKQRSNVESQKRRVDALIEDENGAVEEERGSVELDRVQRTEQQQVQQVTPQELEFQETLIAEREAEIREIESGIHELNDIFRDLGTIVEQQGGLVDNIESNITSVAQNTSSAADELTTAHEYQRKAGRRMVCLLLILIVVVLVILLAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBQ5</accession>
    <name>A0A1Y2BBQ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tubby C-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_593108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBQ5"/>
    <dbReference type="InParanoid" id="A0A1Y2BBQ5"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="202" mass="22394" checksum="24FE27FD1BD6707C" modified="2017-08-30" version="1">MGLFTSSAPMQLAPIHPPLGMHPQYCVNVPTTLVLKEKAFSFSGDDFAVKDSNGIPVVHCKGKAFSFRDRKVITDNNGNLLFHLRNKMIAIHKTFIAEDEQERELFRVKKRLAIGTKMEATFVNQSTGQPVTLELRGDMWGGSADLSMGGMPVAQISRKLFNARELFVDKQTYFVTVAPGVDLALIAAICICFDEAKNENDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBV3</accession>
    <name>A0A1Y2BBV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_523929</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBV3"/>
    <dbReference type="FunCoup" id="A0A1Y2BBV3">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBV3"/>
    <dbReference type="InParanoid" id="A0A1Y2BBV3"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY32318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="974" mass="109961" checksum="DB965BF168A71BCA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBX6</accession>
    <name>A0A1Y2BBX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_464659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBX6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBX6"/>
    <dbReference type="InParanoid" id="A0A1Y2BBX6"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="10">
        <location>
            <begin position="243"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="551"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="581" mass="65242" checksum="DC7419B02F483FF4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BC13</accession>
    <name>A0A1Y2BC13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_525214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY32017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BC13"/>
    <dbReference type="STRING" id="71784.A0A1Y2BC13"/>
    <dbReference type="InParanoid" id="A0A1Y2BC13"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="694" mass="76245" checksum="92C13EEDBAAACDBB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCG8</accession>
    <name>A0A1Y2BCG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_375873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCG8"/>
    <dbReference type="InParanoid" id="A0A1Y2BCG8"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="230" mass="25891" checksum="2DFD0012D29D7EE8" modified="2017-08-30" version="1">MTRQPTNWLTTAATASSGSRNVSVEVSIEGSGGSSTFRDIFLRKFLQRGPHSFEGDTTTFRFSESEIPDSKEVNMEPAESKTNFLLRRRYQTNSASLTEAGFTGLVQKRKGEAPVPAMATISFISEARAPIGYDSQRPSKWEVEKSLRSSFLTAPDTEGNHLHRLTIPMKTCKMNRPYEQHIGTTRATVRQWQSGGSTQQEPMKTWKDVKSPSSVNFQNKRDERSRYKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCH6</accession>
    <name>A0A1Y2BCH6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_523521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCH6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCH6"/>
    <dbReference type="InParanoid" id="A0A1Y2BCH6"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01863">
        <property type="entry name" value="Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001312">
        <property type="entry name" value="Ras-related protein Rab-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="171" mass="19210" checksum="9F89B748BF114827" modified="2017-08-30" version="1">MPELPSNLKLLLIGNSSVGKSSLLLRFTDDDFISEEETAATIGVDFKVKSITLDGHKYRLSIWDTAGQERFRTLTSSYYRGAQGVILVYDTTSRATFDELLKWFKEIDTYCSEGVVKMVVGNKVDKEFSRQVTTEEGRAFAHRMGTLFIECSAKTKVGVEEAFKELVARVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCX6</accession>
    <name>A0A1Y2BCX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_492689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCX6"/>
    <dbReference type="FunCoup" id="A0A1Y2BCX6">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCX6"/>
    <dbReference type="InParanoid" id="A0A1Y2BCX6"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="110"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="594" mass="63871" checksum="30EC75058C875D31" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD99</accession>
    <name>A0A1Y2BD99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MBOAT, membrane-bound O-acyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_521632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD99"/>
    <dbReference type="FunCoup" id="A0A1Y2BD99">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BD99"/>
    <dbReference type="InParanoid" id="A0A1Y2BD99"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="571" mass="64010" checksum="BEC6F62A80B66E5E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDE6</accession>
    <name>A0A1Y2BDE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative short chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_355886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDE6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDE6"/>
    <dbReference type="InParanoid" id="A0A1Y2BDE6"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="380" mass="42166" checksum="D7D6778E55DF143C" modified="2017-08-30" version="1">MLEQVSTVCRSLLDWFLDKLNVVFHSGLPLFFWVRPRWSLLDMPDMSGKVVIVTGGNSGLGYVTCKALYDKGATVYMASRSAKKAHEAIGAIKKGGVFGVTGITYPKRNESNNAGRGRLEFLELDLADLESVEKAAEEFQHKESTLDVLFANAGVMASQEGLSTKQGYTLQFGTNCLGHHLLVSLLLTTLLATPHSRFISSTSAGHYAAPRGGVDLRSVIRDPKDPSNTKRGKYEHMKWIEYGQSKWGNIALAKWVHWAYGPEEGARKEKVESYDRSTGQIISIAIHPGLVATNIAQHLLLTPYILEFTLWLTPAIATSPGIGALNQLWAATCPVEEARRLSGEYIVPYQQIGRARPDLNNPERIVALWKWCDEQTRRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE16</accession>
    <name>A0A1Y2BE16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_463909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE16"/>
    <dbReference type="InParanoid" id="A0A1Y2BE16"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="483" mass="53797" checksum="26BC79F833A5086A" modified="2017-08-30" version="1">MDEKKDGYTNPAFVITEEALEHEVGLDLYRDAADLEYTPAEAKKVRRKIDAWILPMFCMCQGLAYLDKTGTNYGNLFGMRASLHVSTAQFAWFASAFYIGYLICAWPANLALQKYPTGKVMGIVTFFWGIVSVTPGLGLMTPLWWTLQEQPIRHLTWYCFNGVASIIGSLVAYGLGHATHSAVATWKLIFIVFGSFTSLWGIFIFIFLPDSPASAKFLTPEQRIIGVKRVAENRTGTKNTEFKWEQVREAFVDPKLYLLFVAAIAAQIPNGVVSNFSTIIIKGFGFTQLQTTLLDIPNSVVQISSLILSGFLAGRFKNSRAILMFVGNATCIVAACALTYAPHHETWGRLVAFWFTSFQSVGFSLSLVMISANIGGYTKRQTTNAITFIGYCIGNIAGPHVLLEREATTGYPTATKAMLAGYVVKTVTHLVLGAYMLYWNRRWDKMAIARGELLSEAQRRKLAEEVGMTDATEFNNPYFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEN4</accession>
    <name>A0A1Y2BEN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_375900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BEN4"/>
    <dbReference type="InParanoid" id="A0A1Y2BEN4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="178" mass="20451" checksum="47D4AFECC737D7F8" modified="2017-08-30" version="1">MYPTAGPSRSNPNPLAAGRGLTGSVPPPRGGSSRRDVDFDRDREDWTGGYGRGDIPDQQGLNRARLSGRGDGFRPTRGRSRTPSPRRRDVQSRDDLDRDMERFRDRERGFDGRDSWPVAEPPRGPAGWRDISPRRGSNFASAPSRERPREPRESEWDRKQRFNERNGTERFRDESRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF84</accession>
    <name>A0A1Y2BF84_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_303286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF84"/>
    <dbReference type="InParanoid" id="A0A1Y2BF84"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="64638" checksum="26CC946941E6EB41" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFV8</accession>
    <name>A0A1Y2BFV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_519583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFV8"/>
    <dbReference type="FunCoup" id="A0A1Y2BFV8">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFV8"/>
    <dbReference type="InParanoid" id="A0A1Y2BFV8"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="6">
        <location>
            <begin position="157"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="392"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="462" mass="50393" checksum="32638907FC267D57" modified="2017-08-30" version="1">MSDPRIGDRELAQINASAAIREYGVNPRMDYRTVAAVNGPLVVLDNVSFPSYNEIVQLTLPDGSIRGGQVLEVSGKKAIVQVFEGTSGVDTSATRIAFSGSSMKLAVSEDMLGRVFNGSGNPIDNGPKVWAEEYLDINGSPINPFSRIYPEEMIQTGISTIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKRPGATKGVHDGHEDNFSIVFAAMGVNMETARFFKQDFEESGSISNSTLFVNLASDPTIERIITPRLALTTAEYFAYQLEKHVLVVMTDMSSYADALREVSAAREEVPGRRGYPGYLYTDLATLYERAGRVEGRNGSITQVPILTMPNDDITHPIPDLTGYITEGQIFVDRQLHNRQIYPPINVLPSLSRLMKSAIGEKLTRKDHGDVSNQLYAKYAVGKDAASMKAVVGEEALSADDKLALEFLDRFEKEFVGQGGCHSMLCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG01</accession>
    <name>A0A1Y2BG01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein of the DRG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_518947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG01"/>
    <dbReference type="FunCoup" id="A0A1Y2BG01">
        <property type="interactions" value="896"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BG01"/>
    <dbReference type="InParanoid" id="A0A1Y2BG01"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="290"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="368" mass="40275" checksum="CCDD75CB47022484" modified="2017-08-30" version="1">MTTAQKIKDIEEEMSKTQKNKATEYHLGQLKAKLAKLRRELIAPPSGGGGGPGIGFDVARTGIASVGFVGFPSVGKSTLMSKLTGTHSEAASYEFTTLTTVPGTLTYNGARLQILDLPGIIEGAKDGKGRGRQVIAVARTCNLIFIVLDVLKPLIDLAILTNELEGFGIRLNKRPPNITVKKRDNGGIAITNTVPLTKIDAGAIKAVLSEYRLTSASVSIHEPDATVEDLIDVVEGNRVYVPAIFVLNKIDAISIEELDLLYKIPNSVPVSSKDWWNIDELLEVMWEKLNLVRVYTKPRGATPDYSSPVVLRRGKCTVEDFCNAIHKEIKSQFRNAMVWGTSVKHSRGQKVGLDHVLEDEDIITIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG50</accession>
    <name>A0A1Y2BG50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_268546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG50"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG50"/>
    <dbReference type="InParanoid" id="A0A1Y2BG50"/>
    <dbReference type="OrthoDB" id="2589068at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="389"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="914"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1099" mass="122195" checksum="B640607D83FF89C9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGV8</accession>
    <name>A0A1Y2BGV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin motor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_518253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGV8"/>
    <dbReference type="FunCoup" id="A0A1Y2BGV8">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGV8"/>
    <dbReference type="InParanoid" id="A0A1Y2BGV8"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000096">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="5"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="664"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="935"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="982"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1119" mass="120479" checksum="557A00AA76710F53" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BH10</accession>
    <name>A0A1Y2BH10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_518425</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BH10"/>
    <dbReference type="FunCoup" id="A0A1Y2BH10">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BH10"/>
    <dbReference type="InParanoid" id="A0A1Y2BH10"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000133">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="21"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="704"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY34091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1089" mass="124118" checksum="1307E2A1EE2362B7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHK3</accession>
    <name>A0A1Y2BHK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NAD-binding Rossmann fold oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_517304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHK3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHK3"/>
    <dbReference type="InParanoid" id="A0A1Y2BHK3"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="166"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="458" mass="50130" checksum="69B40CE1DD73E1E3" modified="2017-08-30" version="1">MAETEIPKQNGTKEPVNGIRNGNGNGIKPVTIAVVGAGQRGQIYANFAIEHPEAAKVVAVAEPRPHRRKVISRLHSIPPENQFSTWEQLIAKGKIADAVLICVLDDLHAALVTEFTKQGYHILCEKPMATSIEDCVQMVQDVSAHPDQIFGIGHVLRYSPYNQAVKQVIDSGALGEIINIQHIEPVGNQHFAHSFVRGNWHKESTTSFGLMTKCCHDIDILSFYLSGLKPSLVSSFGSLQHFRPSQKPKEAGNAKNCFDCAYEKDCVWSAKKIYVEPLGQPTDSERWARHVVDADVLDIENVSEALKTGPYGRCVYEAGNDIVDHQVVNVEYEGGVTGSITMSAFTEAICDRGTRIQGTKGELIGDMQTFTVFDFLTRTKTLHEPPLEGGGHGGGDSGLSRAFVKAVAGLDQTRLGVTPDDVLNSHLLVFAAEKARREKRVVDFELFKKGCLAGTEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHP6</accession>
    <name>A0A1Y2BHP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_194898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHP6"/>
    <dbReference type="InParanoid" id="A0A1Y2BHP6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="23900" checksum="981338505B2D9826" modified="2017-08-30" version="1">MCKTGALNLCATHSFDVKCCSSNHLILEESPFRPWSGRVIMESVTNESARSVIFLPSQQAFSFIPIDRIYAVLELHSDLAPSLSASHTSVVTAPLVSFDHPFQCRSPGSLAIPHLHHPPTSVDHQRNQPCISPNPPTIFGYHFESASSLKMAVSQRIRTIFYPALISKEPKRTPMVCTQRKSNPRPPLTSQLTPSKHHHAADDNDGGSQGSRSALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI58</accession>
    <name>A0A1Y2BI58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_517142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI58"/>
    <dbReference type="STRING" id="71784.A0A1Y2BI58"/>
    <dbReference type="InParanoid" id="A0A1Y2BI58"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="759" mass="81734" checksum="19E7B27D27E07E29" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ26</accession>
    <name>A0A1Y2BJ26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_572492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ26"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJ26"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ26"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="334"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="163"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="340"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY34590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="468" mass="51178" checksum="3237636B35AD5A1A" modified="2017-08-30" version="1">MAPITVKKICCIGAGYVGGPTCAVIALKCPNIIVTIVDLNQARIDAWNSDNLPIYEPGLDEVVKARRGKNLFFSTDVDKAIAEADLIFVSVNTPTKKSGIGAGFAADLNYLQLATRRIAEVSTSSKIVVEKSTVPCRTAESMRTILEANSKPGCHFQILSNPEFLAEGTAIQDLFAPDRVLIGSLQTDEGLDACKALMSVYSNWVPTERILTVGLWSSELSKLAANAMLAQRISSVNALSAICEATGANIDEVAFAVGKDSRMGSKFLKASVGFGGSCFQKDILNLVYLSESLHLPEVAKYWRAVVEMNEYQKDRFAHKVVETLFNTITGKKIAILGWAFKKDTGDTRESPSISIANHFLSEKARVTLYDPQVTESQIWLDLTNYGEVPAEPIKPHVTICESAEEACKGAEAIVVCTEWDEFKTLDWEKIYKNCPRPAFVFDGRLMLDRKALQKIGFSVVTIGSGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ35</accession>
    <name>A0A1Y2BJ35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_514841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ35"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ35"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="603" mass="67762" checksum="2C7F7029AD9B5DC1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJN6</accession>
    <name>A0A1Y2BJN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">3-oxo-5-alpha-steroid 4-dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_132738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJN6"/>
    <dbReference type="FunCoup" id="A0A1Y2BJN6">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJN6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJN6"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="155"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="312" mass="35475" checksum="872DA7545FED494D" modified="2017-08-30" version="1">MVAVTLSTSGKPSINLNFADKHPDQVTVKDLKLAVQAKFPKYVPNRQRITIPPPGGSGKSTALTDEDRSIGSYGVSEGSKLRLKDLGKQVPYRTLYLWEYVGPIFLNPLFLHFSYLLWGPYTPSTLQLAVRNLTIIHFLKRFLESIFVHSFSRPTLPLAYVFRNSLYYWGVNGLLIGLTFYRPGNSASALKGTIYDDPRWIYGWTTWILINEALNLYTHLHLASLRTPPGHPRKFPTGFGFGTVVCANYWFETLQVLGTVAITGGDPGSLVYLVISTYFMQLWAGQKYARYKKEFDPKIFPGKRWKMFPPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BK68</accession>
    <name>A0A1Y2BK68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_516029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BK68"/>
    <dbReference type="STRING" id="71784.A0A1Y2BK68"/>
    <dbReference type="InParanoid" id="A0A1Y2BK68"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY35007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="164" mass="18130" checksum="144CBAEBC7125991" modified="2017-08-30" version="1">MSVTLHTSLGEIKIEIFCEAVPRTAENFLALAASGYYDNTIFHRNIKGFMIQGGDPNGTGKGGQSIWGRPFPDEIRQTLRFNTRGVVAMANGGPDTNKSQFFITYAKQPSLDGKYSIFGKVIDGVDSTLDMMERVPVNEKNRPLNEIKLNSITIHANPIADQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKC3</accession>
    <name>A0A1Y2BKC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_556578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKC3"/>
    <dbReference type="InParanoid" id="A0A1Y2BKC3"/>
    <dbReference type="OrthoDB" id="2596771at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1849"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1714"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1862"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1899"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1927"/>
            <end position="1940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2302" mass="257281" checksum="1CFB87E31806A601" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLI1</accession>
    <name>A0A1Y2BLI1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_563098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLI1"/>
    <dbReference type="FunCoup" id="A0A1Y2BLI1">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLI1"/>
    <dbReference type="InParanoid" id="A0A1Y2BLI1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="101"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="247" mass="26808" checksum="011B0F3E083E42E7" modified="2017-08-30" version="1">MSYEHVSSQQYIQADDEDLDSLSFAGPATLPQNSGPPTNALSGRIGSGNTPATSRTGWGGVKVETRYTGDSTLDEPVSKTIMRDLNSIYAKLLQVLYPPMGSGNNQLLRDWDLWGPLIICLSLAILLSVDAPPDQSMQVFSLVISLITIGSVVVTVNSKLLGGKVSFFQSLCVLGYALAPILLASAISTLVHNIFVRIPISLACFAWSVWASMNFFNGTGLPDSRTFLAVYPMCLFFFVLAWMIMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLZ3</accession>
    <name>A0A1Y2BLZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mitochondrion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_512155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLZ3"/>
    <dbReference type="FunCoup" id="A0A1Y2BLZ3">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BLZ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLZ3"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="197" mass="21673" checksum="8359A741AFABD317" modified="2017-08-30" version="1">MPKVFENDIVYDWNPAHVLSKLHQKYPNPYATHVHSVDTLERTIDPETGIIRSERIVGVVQGAPGWITKLFHLPPTAYVREVIFVDPSIPKATCMSVNLSLAQYVSCLELITYNPHPSPSNPSDPPPEPGHLGPLAVVPQTIFNQRALITSGFPTAMVARRVEKASVDRFGKNAGLGKRGFDWVLNGGSDPKTASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM23</accession>
    <name>A0A1Y2BM23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_512429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM23"/>
    <dbReference type="FunCoup" id="A0A1Y2BM23">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM23"/>
    <dbReference type="InParanoid" id="A0A1Y2BM23"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="891"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="926"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="954"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="986"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114332" checksum="70CD380F93974FD8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMH8</accession>
    <name>A0A1Y2BMH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_512928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMH8"/>
    <dbReference type="InParanoid" id="A0A1Y2BMH8"/>
    <dbReference type="OrthoDB" id="549336at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51515" checksum="DF2905CF35CAE53B" modified="2017-08-30" version="1">MPLSSSTVAYSSKDRSPDRNPLPAMSPSPSILKRRRPLLFLALAAAGVFAYFSFHPLGSRYTNVAATLPNVRKDAVIVFESAIHDEVNGALGNSLVLAGFDPLFICSFRYDFEMILGNLTYPLVPRIQSPYRMPKEVSVESRIDRGEVDVLVLTTCSQALPKLLSHLEPTNTKVVCVVHHSGQPAYRDLKPLIVGLAKQRRIGLLVLGEHVRQRLHSERLQWAEREAEDAWLDMPIEVLVPTFDYPAKPTTPSPAIFPSRVVIQGNIEPGRRKYDAVLRHLTEAMTANPSNWGWKYDSALEKFVQDSSGSPFTLHLLGRRNEQHPVEIKKEIEDVVHIHPDLSYPQFYEFLNGVDLIVPAFGQNGPYEDTASSSIAAAVIVRVPALVTERHLNSYTYLAPPAIVTHSVVESEIAAIERLRTSGDQWQLRRASAKDWRRYQGRLDSENVETWGRVLRTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BN77</accession>
    <name>A0A1Y2BN77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="4">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HCR1</name>
        <name evidence="6" type="ORF">BCR39DRAFT_511149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BN77"/>
    <dbReference type="STRING" id="71784.A0A1Y2BN77"/>
    <dbReference type="InParanoid" id="A0A1Y2BN77"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY35615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="252" mass="27648" checksum="16A1DABDF7368711" modified="2017-08-30" version="1">MDDDWDVEESPAQSGTSTPAVPAVPVVVRAPARARWQGEDEEDEQDDWDASEDEKPKTPTTTAPAPTKKKGGLKQKLAEKERLAAEARERGEIDDLIDTTTEQDRRRQAREREIQADLNVAADLLGVTSVDDPKETLEAILKSKPTSKDSFATLSKQIVATFISRHESNPLFPAFAESLAKDLCESLTAVQTRKVASGLSTLGNTKQLEERDKANGKKKATTKPKLGAVKSLTTQIDTEAYTETFDDGDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADG6</accession>
    <name>A0A1Y2ADG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000130">
        <property type="protein sequence ID" value="ORY20598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADG6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ADG6"/>
    <dbReference type="InParanoid" id="A0A1Y2ADG6"/>
    <dbReference type="OrthoDB" id="2563954at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="116" mass="13010" checksum="733D466D0D72CAAA" modified="2017-08-30" version="1" fragment="single">RRVSKKRKTKKHTEEKNPDPDPDPDPDDDDEFIDPEVWDEDLFMPIEDVPVPPLEELADEAMRSMGAKTKDELREVVVKLVNQGREGVTAEQLTQLKGLLTLMGARGVLSTGSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADK4</accession>
    <name>A0A1Y2ADK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vps53-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_555096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000129">
        <property type="protein sequence ID" value="ORY20639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADK4"/>
    <dbReference type="FunCoup" id="A0A1Y2ADK4">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ADK4"/>
    <dbReference type="InParanoid" id="A0A1Y2ADK4"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.110:FF:000004">
        <property type="entry name" value="Vacuolar-sorting protein 53 long isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="10">
        <location>
            <begin position="625"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="737"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY20639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="802" mass="89711" checksum="BD0CF2A9C8ABDA82" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEF3</accession>
    <name>A0A1Y2AEF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000121">
        <property type="protein sequence ID" value="ORY20958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEF3"/>
    <dbReference type="InParanoid" id="A0A1Y2AEF3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="117" mass="12731" checksum="B2A0AEF9F05994C2" modified="2017-08-30" version="1">MTNPSSATPITPKKGRPRESSSSNPGPIKTKPKKPKTSPSNILDNDNDNDTDQHSYSWTPEKREVIVDYLIGRAISGLDYDELASKVGLSKAQLKNALAKGQKSNLRDRLVTAAKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AET7</accession>
    <name>A0A1Y2AET7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_508472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AET7"/>
    <dbReference type="InParanoid" id="A0A1Y2AET7"/>
    <dbReference type="OrthoDB" id="2595994at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="119" mass="13551" checksum="95E3430DF3C80213" modified="2017-08-30" version="1">MPAKREADSLPQYSAMSNDFLQFLNSVESTSTPSPKKKKLETGRPQTDKPKTESTSISPKSPREIRNWTPEEDAIFLNPMLDTLKEHLFQRVKADGRLDRQNPAVRAHLVAFMNKLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFL6</accession>
    <name>A0A1Y2AFL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative vacuolar ATP synthase 22 kDa proteolipid subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_554004</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000115">
        <property type="protein sequence ID" value="ORY21252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFL6"/>
    <dbReference type="FunCoup" id="A0A1Y2AFL6">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFL6"/>
    <dbReference type="InParanoid" id="A0A1Y2AFL6"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY21252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="198" mass="20558" checksum="82E445E8CC8702F4" modified="2017-08-30" version="1">MGYLAPALLLSSTATFTVVALYLLFTGQGEKFNVGNFLAESSPYTWAFLGIGLCIGLSVLGAGWGIFITGASILGGGVRAPRIRTKNLISIIFCEVVAIYGVIMAIVFSAKTGSVPEIYTAANYYTGFSLFWGGLTVGLCNLFCGISVGITGSTAALADAADPQLFVKILIVEIFGSVLGLFGLIVGLLVSGKAEEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGV3</accession>
    <name>A0A1Y2AGV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_562620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000109">
        <property type="protein sequence ID" value="ORY21520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGV3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AGV3"/>
    <dbReference type="InParanoid" id="A0A1Y2AGV3"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY21520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="624" mass="67426" checksum="F46AFD7ECDB76702" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH50</accession>
    <name>A0A1Y2AH50_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_591459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000102">
        <property type="protein sequence ID" value="ORY21903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH50"/>
    <dbReference type="STRING" id="71784.A0A1Y2AH50"/>
    <dbReference type="InParanoid" id="A0A1Y2AH50"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY21903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="573" mass="62785" checksum="8C997F0DA0292A4F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHZ4</accession>
    <name>A0A1Y2AHZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_50611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000104">
        <property type="protein sequence ID" value="ORY21807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHZ4"/>
    <dbReference type="InParanoid" id="A0A1Y2AHZ4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="217" mass="23615" checksum="1009F9935F08D2BF" modified="2017-08-30" version="1">MQSLLKAKPRRKRRCDPASVSDGSTNQPWKSNSSPRTALISGNAAVPPSTPPSEFTTNLNSNGKRPASRPHMEAPNLHTHVHANTESPLQRAPYVEIDSSPGHNLIPTGSARGTITTANESSVSVEAGTSTNPAEFDELGSSIHASLNLLHARSILRSKLQAQIEEEQIQREVVQRQLRELADRQAALQLQLQRNKEESDALKAKLGKSVSDLLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJE2</accession>
    <name>A0A1Y2AJE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_372605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000089">
        <property type="protein sequence ID" value="ORY22693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJE2"/>
    <dbReference type="FunCoup" id="A0A1Y2AJE2">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJE2"/>
    <dbReference type="InParanoid" id="A0A1Y2AJE2"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="8">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY22693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="203" mass="22648" checksum="9514B8B111E5F13C" modified="2017-08-30" version="1">MSKRGLSVEEKKTKMLEIFHDTSEFYTMKELEKLGPKLKGVVQQTVKEIVDDLVSDDLVCFDKIGTSNYYWSFPSTAGATKQAALSKVQQELQSVNAKIEETSEALEKAESGREDTAERRKLLVALSAVQAESTALKDELAAFGAADPIRYERKKAATQVCKDAAYRWTDNTMILLGFATTLGAEEDQMRAMLGMSEDWDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJV9</accession>
    <name>A0A1Y2AJV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_382624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJV9"/>
    <dbReference type="InParanoid" id="A0A1Y2AJV9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="175" mass="19016" checksum="5028796F9FF85338" modified="2017-08-30" version="1">MLGGDEVGVNANPLNADEVGEKVSLMYADGVVIVSRKAIALALQEASVNQKVIELVEAAVENGTRFVHDEEGVNVHRTRDEEVGNENQRENDVWEVESGNLRAIWDDEGASERWVDLEGVEASRISRVVVEEGTVSRDHDAEVVVILNLHVSLGRLGLLALLAFFKGSAGPGYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKE6</accession>
    <name>A0A1Y2AKE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_550279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
        <property type="protein sequence ID" value="ORY22964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKE6"/>
    <dbReference type="InParanoid" id="A0A1Y2AKE6"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="483" mass="52892" checksum="94CB6A21C33F49F3" modified="2017-08-30" version="1">MDQAPSLTAAAALTDSRVLADSSLPPVVAESSENAAASSSPSSDRPTSPTETIKPEDSISTSVQPLTTAQRAFQYGLDRGNLEQEVGQVMGTLNSWWGGVKKQGATALSTIKADLDKTVSQAQADIEHLRTTKIEVVRKQSGDDSSISPSDKGKSKAINLNDEAPAATSSLMDRLSASTALFQQSLQTTLAAATSNPALSNPSQLRAQLAQNLQLSSARQNLQLSVLQAEKLAEEYMRRGDQWIKDAEKWVGDAVKLLPPEGEETRFVGMDGSDFYSFSTSSNPVERGVIFDAESRTPRASVAGSRKEALLRRLRGDQELLLVDPEGTDESAERHQQFREWIEQKWPAAEGDKVQELGHVGGIRMALVPEHLSDEQFWQRYLFHKHMIEAEEERRKLLFDTSRQTQADDFSWDDEAEEVPQGMDSSTPKVSEESKMPVALAVKPDASTSTSPRDSEESYDLVSDQGVKNKAPPPGDDEDSDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKL1</accession>
    <name>A0A1Y2AKL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_550150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKL1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKL1"/>
    <dbReference type="InParanoid" id="A0A1Y2AKL1"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="233" mass="26035" checksum="86438C9ED089552F" modified="2017-08-30" version="1">MTQISAQALDPPPAPLFHTHTTLVPPEHEPQTYIPSPSPSGMPTPSLKRPITVRAAQPTTSDAEAIISIGRPVYAATFGPTCSEADLRDYLDSTYTSPLVLAELTDPNKQFFIAVQDLLEASNSLDTVVGFVQLTKGTTEPCLGEYDDIIELQRFYIALDHHGAGVAARLMEHTLSVAKQQQYRHIWLGVYEHNHRARRFYQKYGFKSVGEHDFWVGSDRQTDIVCVRELVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AL16</accession>
    <name>A0A1Y2AL16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_362087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000082">
        <property type="protein sequence ID" value="ORY23192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AL16"/>
    <dbReference type="InParanoid" id="A0A1Y2AL16"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012282321" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33913" checksum="0A3BA1BEBF6DAC5A" modified="2017-08-30" version="1">MMMMMMTQVVMLLSFLTVLLVHVQATAVPTFSSGISPLPSPPATALSPDQLKETLNAFLNAFIAPNDVAQAKEINSTFFADDVIGTVDLSTTFVGRELNTEYTFGLFAILAQSPTDPALYGQPVSANVTALVIQGQTVALGMIVMFNYLTLNKAFPVEIDGFFTFNDQSKIQQYDVTFRRYAWASQIITPQLIPLMAKAINISSTNGTYVLQQYLATRTCQGAEQYCTGDNKQYDSYDSCMSFATSIDLGEAWRLGDNNLNCRYLHTAMLPLRPSVHCPHVGPSGGDMCIPRDYDAVVYGSAFQYGLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM03</accession>
    <name>A0A1Y2AM03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_487517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000085">
        <property type="protein sequence ID" value="ORY22965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM03"/>
    <dbReference type="FunCoup" id="A0A1Y2AM03">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AM03"/>
    <dbReference type="InParanoid" id="A0A1Y2AM03"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY22965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="471" mass="52574" checksum="9606D86E59E13724" modified="2017-08-30" version="1" fragment="single">MNEAESSQLVNEINDHGGWVNTSLFRLGPIDGMGTGAVAIVDIPEQTPLFHLPLDQLLMSHSSDIKNRLSSSEWDGLGQGWIPLILAMMWETHIGEESRWQAYLSSMPVTFETPMFWDEDARRELQGTEIENTIGREEADNDYRTILRPVLERHPELFPSSSNHFTLEAYHMHGSRILSRSFTIPAILTGALDNDDDDEDDDDDDDDDDEEDANEVAMIPMADMLNAVTGLDNARLFSHEEATAQSVVKGKGYTMISTSAIKAGEQILNTYDVVPNSGLLRKYGHVDTLPLPAKILSLLSDEEIGQWPLGNPADEVSIAGDLVVEIVTQRAGTGKSAEYQARVDRWLDEQDDTFVLSFTTPIEPQLIVFIRILIFDSEWQRFLKKGKLPLPVIDDSVAKLLFDILDARSSRYLHSLKDDLILVTAIPPVERRQYMSAVVRIGERRVIAAARRTVRAQTTMQGAGGVGKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AML5</accession>
    <name>A0A1Y2AML5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_548601</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="MCFC01000075">
        <property type="protein sequence ID" value="ORY23813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AML5"/>
    <dbReference type="FunCoup" id="A0A1Y2AML5">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AML5"/>
    <dbReference type="InParanoid" id="A0A1Y2AML5"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="49"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="236"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY23813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="466" mass="53862" checksum="C7587598F8E54C2F" modified="2017-08-30" version="1">MSNLIIESIGNGIDRLAQLADNPTIDYQQVAIYGSWLLTTFEVYLYKQQLKQYDIKVIPTELVEHLPRETFDKSQAYGRDKTRYSLIKKVFDQILSVLLIQFGLFTKMWDWSGVCITKLGLSDDRIITRSLIWTIIYVAISTPIGIPWDYFYTFVLEEKHGFNKSTVKLWWIDKAKTMALMAVLGLPIWGAFLWIINWAGKDFVPWLMLFMIVIQLSMQIIYPIFIQPLFNKLTPLPDGEVRTRVEVLANKLGFPLKHLYEIDGSKRSSHSNAYFYGLPWNKHIVIFDTLMEQSTPAEVEAVLGHELGHWYLSHPSKLLLIGNLHLLFTLTLFAVFIHNTTLYKSFGFDPSLALDGPRGPPANVIGFTLFQLLLEPLDAPVKFLFNSITRKYEYQADEFGVKLDKRQELKTALTKLHVKNLSSPYNDALYSMYHHSHPTLTERLRALDEYKDDGKPLKIKSEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AN95</accession>
    <name>A0A1Y2AN95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E1-E2 ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_344755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AN95"/>
    <dbReference type="STRING" id="71784.A0A1Y2AN95"/>
    <dbReference type="InParanoid" id="A0A1Y2AN95"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1211"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1241"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="11">
        <location>
            <begin position="747"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY23687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1275" mass="136884" checksum="B9191E9B556D79CF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANC0</accession>
    <name>A0A1Y2ANC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_547843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANC0"/>
    <dbReference type="FunCoup" id="A0A1Y2ANC0">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANC0"/>
    <dbReference type="InParanoid" id="A0A1Y2ANC0"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="536" mass="57793" checksum="4F3F337F87C1FEBC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANH2</accession>
    <name>A0A1Y2ANH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_547882</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANH2"/>
    <dbReference type="FunCoup" id="A0A1Y2ANH2">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANH2"/>
    <dbReference type="InParanoid" id="A0A1Y2ANH2"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="556" mass="60733" checksum="79301284D3C06CD0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANP0</accession>
    <name>A0A1Y2ANP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_590722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000071">
        <property type="protein sequence ID" value="ORY24132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2ANP0">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANP0"/>
    <dbReference type="InParanoid" id="A0A1Y2ANP0"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000020">
        <property type="entry name" value="Chromosome 10, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="502"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="713"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1348"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1553"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2158" mass="243976" checksum="3F66B196043FA7F0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APH5</accession>
    <name>A0A1Y2APH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_566630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APH5"/>
    <dbReference type="STRING" id="71784.A0A1Y2APH5"/>
    <dbReference type="InParanoid" id="A0A1Y2APH5"/>
    <dbReference type="OrthoDB" id="2101715at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34587" checksum="82C50B0CCDA6D8AA" modified="2017-08-30" version="1">MYLPYSRPRLIEIHEQAWCPPSIRRPIQTMLAFLWTHRIAPFQARAPYEAVVDIVQRVLLDIEDEDERDQEDRGTLQLLDCCSGAGGPVPAIERDINSRRSLASKPPVKVFLSDIHPHLESWIHHSMESPTRSLSYLTFPVDAAHVPAHLKEERHLRTFFLAFHHFSEDAARRVLEDAMRTAEGICIFELQAPDLGSIVTILALFPLSFLLIPFQHPTITTLLFTYIIPIIPAILIFDGLVSAWRTRSPQHIQYLAGLAAMTVQLEGGDKEGEWKWESGGGVHTWPWGRMSYVIGRRDRGGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARP6</accession>
    <name>A0A1Y2ARP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_545725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000063">
        <property type="protein sequence ID" value="ORY24887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARP6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ARP6"/>
    <dbReference type="InParanoid" id="A0A1Y2ARP6"/>
    <dbReference type="OrthoDB" id="2563633at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18224" checksum="F9099A8DDE27B32E" modified="2017-08-30" version="1">MSYKDPSSNPSIELDPLHNGATVRRAFLLEAILNLCSFPLLTHPHIVLPYILKHPDQLNTSTLLFARLFGGLIIGGLTPALLAGYPNTRNAIESRKTVYILLGLGEVVLIPLLLLEGLKSGKQQALTLRATMGAVACLAPPLLWRIYVLFWNKGLLGRYREVKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS12</accession>
    <name>A0A1Y2AS12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_544292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS12"/>
    <dbReference type="FunCoup" id="A0A1Y2AS12">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AS12"/>
    <dbReference type="InParanoid" id="A0A1Y2AS12"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="57"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY25322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="559" mass="60783" checksum="A95187EF392DF4CA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASA1</accession>
    <name>A0A1Y2ASA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_544134</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASA1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASA1"/>
    <dbReference type="InParanoid" id="A0A1Y2ASA1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="819"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="882"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="252"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1066"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1080"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY25449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1180" mass="130231" checksum="10FF15312D97101B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASU3</accession>
    <name>A0A1Y2ASU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_544720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASU3"/>
    <dbReference type="FunCoup" id="A0A1Y2ASU3">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASU3"/>
    <dbReference type="InParanoid" id="A0A1Y2ASU3"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="128"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="269" mass="29871" checksum="0A4871FA9F359080" modified="2017-08-30" version="1">MPKATKGKSRPAATPYGTKKTTKTTQNPLFEKRSRSFGIGGDLAPKRDLTRFVKWPEYVRLQRQKVILHQRLKVPPAIAQFSQTLDKNTATQLFQLLNKYKPESKQEKKARLTAEAEKREKDGDKATTKDTKKPVYAKYGLNHVVALVEAKKAQLVVIADDVDPIELVVFLPALCRKMGVPYVIVKGKARLGLISGKKTSAVLAVTEVRSEDQQALANLVSAAKANYLDKSEESRRHWGGGVRGNKSIAKLRKRAKALGQDAKKIDVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT27</accession>
    <name>A0A1Y2AT27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mate-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_543555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT27"/>
    <dbReference type="FunCoup" id="A0A1Y2AT27">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AT27"/>
    <dbReference type="InParanoid" id="A0A1Y2AT27"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="732" mass="78830" checksum="2B56E26AD6C169EA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AT40</accession>
    <name>A0A1Y2AT40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_287932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AT40"/>
    <dbReference type="STRING" id="71784.A0A1Y2AT40"/>
    <dbReference type="InParanoid" id="A0A1Y2AT40"/>
    <dbReference type="OrthoDB" id="2558768at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY25460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34755" checksum="4C7FF8AADAE96F05" modified="2017-08-30" version="1">MPTAISKPKVETVPATTPIEEILKIIHRDGVIVISDFVPEDEVDRLNAKAVSHFERAEKEGRAQDSFYKNGGRATHTTAAYDLIGSCPEEVTKILQRKAWHQIMEEFLTHKSWDWRGEEKVYRQTGYWLHTTIGYKVSPGANNQALHRDLNSAGIQRTGPESLVNGISTFIAGTNVTAKNGGTHVCPGSHLWPQDRAPKQEDSVAVEMKKGSLAIWLSNIFHGAGENTEDPSNPDAVRIIYGFFAITDNFRQGEATAFSCKPEVFKKMPPEILRLLGLYAGKTGGGRFMGRNPVDTWEPLKGYSGGEWFGAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATY6</accession>
    <name>A0A1Y2ATY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_543219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000054">
        <property type="protein sequence ID" value="ORY25750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATY6"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATY6"/>
    <dbReference type="InParanoid" id="A0A1Y2ATY6"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1274" mass="139106" checksum="57AA13CE8BC12B6E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU29</accession>
    <name>A0A1Y2AU29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_287210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU29"/>
    <dbReference type="InParanoid" id="A0A1Y2AU29"/>
    <dbReference type="OrthoDB" id="2563693at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="679" mass="76058" checksum="7A8C75686A963EBA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUN3</accession>
    <name>A0A1Y2AUN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U2-associated protein SR140</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_541703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUN3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUN3"/>
    <dbReference type="InParanoid" id="A0A1Y2AUN3"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="220"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="6">
        <location>
            <begin position="410"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="7">
        <location>
            <begin position="498"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="702"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="724"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="84010" checksum="B8736EA37DB99A96" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV56</accession>
    <name>A0A1Y2AV56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-5 sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_470347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV56"/>
    <dbReference type="FunCoup" id="A0A1Y2AV56">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AV56"/>
    <dbReference type="InParanoid" id="A0A1Y2AV56"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="341" mass="39809" checksum="1981C177F7082E65" modified="2017-08-30" version="1">MDFLLYWADEYAFDKAYAYLLPYPSTRTSTLLDPHSYNSTTLSEVYSTTSQTYHPSSSSSSSSSSSSNDLLSLLPRDNILRQAISLYVLALLGALLMYYLFCSISYYIFFDRRLEHHPRFLKNQIRLEIKSSMVAAPWIDLLTLPWFLGEVRGKSKLYDDISTYGIGYLVFSATLFLLVTDLSIYWIHRLEHHPRVYKYIHKPHHKWLVPTPWAALAFHPLDGYAQSLPYHIIVYVIPMHKYLYLGLFVFVQLWTILIHDGDMISGHVLERYINSPAHHTLHHLYFTCNYGQYFTWADSYWDSYRSPEPELDPLLDALKVMRKKGLVDEHNNPIGPQDKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVA1</accession>
    <name>A0A1Y2AVA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_270663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVA1"/>
    <dbReference type="InParanoid" id="A0A1Y2AVA1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="264" mass="29088" checksum="3926513ECB979CDB" modified="2017-08-30" version="1">MAEVAGCATSVEYRPNIDRERFPVDDDVVTLGSDDNENMLKGNPIHTHDVEPKTGRDKATTQRTAGSGSKAIRKKEKEPLFLPSEDDIDLSSLLFGKSNQPSREPSSASSVKEPQTLSIRPNKRPSPPDDKMDTMSDKRQKFDGDDLKTDVNLEYSDNLEALLKDDDIMRFVAPSTNSTQPRRMPIKGGPPETQSTPFVQETKRVIENVVKPVADSVWMPCDDGAPRVSTPLGAQDEVDELDSDSDDDREFTSFMNGLTSGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVK1</accession>
    <name>A0A1Y2AVK1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium-activated chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_540925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVK1"/>
    <dbReference type="FunCoup" id="A0A1Y2AVK1">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVK1"/>
    <dbReference type="InParanoid" id="A0A1Y2AVK1"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="52"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="229"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY26484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="790" mass="86427" checksum="C91B01EBE270B42F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWC3</accession>
    <name>A0A1Y2AWC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Flap endonuclease 1</fullName>
            <shortName evidence="13">FEN-1</shortName>
            <ecNumber evidence="13">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_539875</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
            <location evidence="13">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
            <location evidence="13">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="13">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="13"/>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWC3"/>
    <dbReference type="FunCoup" id="A0A1Y2AWC3">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWC3"/>
    <dbReference type="InParanoid" id="A0A1Y2AWC3"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="277"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY26869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="440" mass="48357" checksum="94D1B8E08732AF90" modified="2017-08-30" version="1">MGIKGLTALLSEHAPRCMKEHEMKTLFGRKVAIDASMSIYQFLIAVRQQDGQMLMNESGDVTSHLMGFFYRTIRMVDHGIKPCYIFDGKPPELKGNVLAKRFARREEAKEGEEEARETGTAEDIDKLARRQVRVTKEHNAECKKLLALMGIPVVTAPGEAEAQCAELARTGKVYAAGSEDMDTLTFNSPILLRHLTFSEAKKMPISEISLQLALEDLQMTMDQFIELCILLGCDYLEPCKGIGPKTALRLLREHGGLAGVVQFVRGKMAEKAEENAAAMVEEDDFPSDRESEEGGGGMIINSDGEEVPAASSQAKSTPKKKKKKVTSAGMQIPEHWPWEEAKQVFLHPDVVKGDDLELEWKTPDVDGLVEFLCRDKGFNEDRVRAGAAKLAKMLAAKQQGRLDGFFTVKPKEGTGASAGGKASAKRKGEEKGGAKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWG9</accession>
    <name>A0A1Y2AWG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_497940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWG9"/>
    <dbReference type="InParanoid" id="A0A1Y2AWG9"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="80"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY26794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="529" mass="59182" checksum="8BA0654C9C01A7CE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWP4</accession>
    <name>A0A1Y2AWP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_539664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWP4"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWP4"/>
    <dbReference type="InParanoid" id="A0A1Y2AWP4"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="348" mass="37970" checksum="805233E38FF53EB7" modified="2017-08-30" version="1">MDSMRVITAHCHCGAFSLRHELDPSTLPQPHTLCHCTSCRRRTGQLAVLPVLLPLYFPTSEDHAPLSSYTTCTGINPVTTSWCSTCGAKIFIRTMDSAGQTQWALNLGLIDDPKGLMDVRGHSFLGDTNDGGVSQILWSSLSKYSGEDGDLWEASVPTETMGQSSSLHLRCACSAFSVFLSRPDPTSSPSSRFRAQFCGCETCRLVTGSCIPAVPFISGPLSSVHLHDPLTSNDKPTFNPGKRPAEEEPISLESTLDLSGLSRYESTQGQVSRYFCKTCGASVIYHTAGSPNHIAFNAGLVDSVDGVLAQDWLDWRYEILYFEDAQRWSTVLAWELKDGLAVWCEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWV0</accession>
    <name>A0A1Y2AWV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HSF-type DNA-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_498071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWV0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWV0"/>
    <dbReference type="InParanoid" id="A0A1Y2AWV0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY26717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="196" mass="22238" checksum="A5E2EB90D9F5EBD1" modified="2017-08-30" version="1" fragment="single">MPSPPGFALSSGVPLVNPPAKTQAAFVGKLYKMLEDPDIARTGLIRWSPDGRIFTCPNPTEFSKTILPQFFKHNNWQSFVRQLNMYAFNKVNDLQATTSDPQAWEFRHPLFRRGEPHLLASIKRKSTRPNASDTTHSPPEDDGKGGIAGWMSDAPFVSSPPHERERENERERDRERVRAEVYGMNMQTGEMVTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWW6</accession>
    <name>A0A1Y2AWW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_241064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWW6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWW6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="219" mass="23725" checksum="1C667D67D5E58B4C" modified="2017-08-30" version="1">MMAEQRKRNRSSSVENSSDDSSSGLVVDYRNPPHGSSVSALMASIDSILAAETQQDAAHSSAWNTSGYQMSGLIGPSGIPSSSSSHPTSGSQGAGSQEWYIDAFETVRQSVQDLKTMLRLTDVEEEEKLPLQTRLEMLYRLDDDFQILIPPTSTLRITAQSNSRVSSQNASVPTHSASPVHSTQGSEGAGTQDIYATVEAIRDYVHDLETTLNDVLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXQ3</accession>
    <name>A0A1Y2AXQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_539685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXQ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXQ3"/>
    <dbReference type="InParanoid" id="A0A1Y2AXQ3"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="568" mass="64544" checksum="3D4C69A9E158DD19" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY12</accession>
    <name>A0A1Y2AY12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_589368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY12"/>
    <dbReference type="InParanoid" id="A0A1Y2AY12"/>
    <dbReference type="OrthoDB" id="2593709at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37444" checksum="F4DFA712B3A07D6C" modified="2017-08-30" version="1">MATKALADWNRPSILAVWALYCLISYAIAIGGLTEIRDLLEEMAGQIVDLGLHQQAIAAHYSNQDMVLILFSAFTSADTLFAGLMDTEPFLSSDNFDVKPLAIRFIDLHQASLDELDHNEYFQRAGSELLDLQVASRFNRGWSTCLKKLRAVHVSDGHMIERSWAQLRYNWLQIRLNSLMLIDSTLAAHAYPHLCRAVSQILNCYTELHNLKQLNTSWPQLQRISTCGQILILCMAAGELHKLEAENLFNMLLCLIAEHRPAWPEAEMLLEGFRHAGRCLQIGLGPPVPFPRQDVGTILSIPHLPVGDLESWDDFLEVDTSLVSSTIVLPSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY44</accession>
    <name>A0A1Y2AY44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_589263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY44"/>
    <dbReference type="STRING" id="71784.A0A1Y2AY44"/>
    <dbReference type="InParanoid" id="A0A1Y2AY44"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="182"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY27374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1252" mass="136520" checksum="90D2653C99CE2292" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYG8</accession>
    <name>A0A1Y2AYG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_537511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYG8"/>
    <dbReference type="FunCoup" id="A0A1Y2AYG8">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYG8"/>
    <dbReference type="InParanoid" id="A0A1Y2AYG8"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY27633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="423" mass="45637" checksum="371578CB14CA16BB" modified="2017-08-30" version="1">MFKFDFDLEENEDDNLDLNIPSTEAGPSRPIVPPVSVNSSDQESYEVSLDELLSTLPETILYSPLSLPFLPHPILRRDLHDARFQLASSGIYSDPSLQSPSDPATEADRGTNPVDDEAQYVDAETDLIKGVYEGGLKTWEGGLDILEVLSTIGSSEGGIGDWIRGTSVLEVGCGTALPSSYILHSLLSSSSAGSSPTILHMQDYNLAVLRLVTAPNLLLASLPFLPPTVLHPPIEETDVEDLIPDPQAGTGELHITPELKKAFTSLLAERGVDLKFTYGHWAGLAKSLREDKGNKRAGLVLTSETIYEEASVGDLIDVLKASSLLRAGVDVDSAKAGQKGGSAQDPVVELGDGVERVTLDSWKKNPLRESGESIVLVAAKVLYFGVGGGLQSFLARIEDEKGWWHGVKEWTRGVGRKIVRVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYW6</accession>
    <name>A0A1Y2AYW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_538263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYW6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYW6"/>
    <dbReference type="InParanoid" id="A0A1Y2AYW6"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="133" mass="15293" checksum="C910C628C623023B" modified="2017-08-30" version="1">MSSTSTELPMPQLPRTNEGKRICQVIKVKPEALTEYKKCHGEVWPEVLAALRKAHVVDYSIHFLEPQHLLIAHMRYIGNDFEKDMEGIKESEATRRWWKMTDGMQESFIPGATGSESGPGWWTEAEEVFRMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0C6</accession>
    <name>A0A1Y2B0C6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_207132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0C6"/>
    <dbReference type="FunCoup" id="A0A1Y2B0C6">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0C6"/>
    <dbReference type="InParanoid" id="A0A1Y2B0C6"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="440"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="548"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="684" mass="76862" checksum="4DB2B57BE5B04E81" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0J1</accession>
    <name>A0A1Y2B0J1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_535138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0J1"/>
    <dbReference type="FunCoup" id="A0A1Y2B0J1">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0J1"/>
    <dbReference type="InParanoid" id="A0A1Y2B0J1"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY28254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="556" mass="61469" checksum="79D59867F0970765" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1B1</accession>
    <name>A0A1Y2B1B1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_534374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1B1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1B1"/>
    <dbReference type="InParanoid" id="A0A1Y2B1B1"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="345" mass="36694" checksum="72FDC6436956E495" modified="2017-08-30" version="1">MSFRTFSFPFLGVSLTRSSPLRLLDSHSHSRPDTLILFKRNSTSIMAKEHGHLSAQELFSCKGLTAVVTGGGTGIGLMQTLALVENGAKVFITSRNEEKLQDVAKKYGGDGQSRGQIVPVTGDITSKEGIDKILEAIKKEAPKGINILLNNAGIAGEGSREGYEPSEDAEKFSKQLLKSEFQEWQDIYQTNVTAYYFVSAAFLPLLNAGANSTKGYASQIINVSSISGLLKSASGGQFAYAASKEACVQMSKVMAKEFLPLKIRVNQIAPGIFPSEMTAGDSSQESHKSDLSGTGKGESLPAGRPGNEKDMAAVTIYLASYAGVFLNGQLIHPDGGATVQNPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1H1</accession>
    <name>A0A1Y2B1H1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_534237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1H1"/>
    <dbReference type="FunCoup" id="A0A1Y2B1H1">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1H1"/>
    <dbReference type="InParanoid" id="A0A1Y2B1H1"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="344"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="488" mass="54276" checksum="4BABEC5962B9656A" modified="2017-08-30" version="1">MSNPLPVSGKGGNRARFLANQKKYGHPLPIIIHPPSSSKLSVLSSYLPTFLAPSSSSVERPECVGTFDPVTRSVWVTEPRDMEILFNRGFFGKGTLSRSEPSWRERRIDQVKGGQSAAAEKIREARRIARKQFKIDRAQAMLTAAKAAEAVLTQSTTPGTASSSASVITADEDKVVDGSASPTLSATTTTTIPDVDVSTLTPQTFLIRPTRPDQNRNRGRKAFRRKPPPPQPAPVASSQATESGPSTRVDRPAMEKPVVVVEDTEGEGEGASDDEWDDELVPQMEHLQLALEEAWFLSAGLGVLRIRDPATDTITPIRSLLPLLVTPIPSSISPHPIIRPDDPFLVSYVAYHHFRSLGWVVKPGIKFCCDWLLYRRGPVFSHSTFSCVLIPVYEDLEEKAISPFGNEDWYEERMSWKWMNTIMRVNSLVQKTVVAVYITIPSLNSFPSNCRLQDGTLDPNKVGMRDLLKRYTIREVTLQRFGPARRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1N6</accession>
    <name>A0A1Y2B1N6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_534819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1N6"/>
    <dbReference type="FunCoup" id="A0A1Y2B1N6">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1N6"/>
    <dbReference type="InParanoid" id="A0A1Y2B1N6"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="293" mass="33468" checksum="A4BEDDA7AD1FB4AF" modified="2017-08-30" version="1">MANSTVHGAQSIHGSNPQFLIEKVIRARIYDTLYWKEQCFALTAESIIDKAIELNAIGGVHDRQIPTHFMCLTLKLLQLQPEKEILIEYLLAEEFKYLRALAAFYVRLTFRAMDVYEILEPLMRDFRKLRIRQPGGYAITYFDEFIDELLTKERVCDIILPRLTQRSVLEETEGLPPRKSLLDEDAEEEEARSKRQRLSSRTPSRTPPSSRESSPDLRRRDRSRSASNSESESDRGRYISRSPSPSRSGSEDAQALGEIGDTRGRYVSRSPSISPDRVLEVAGEGDDRIDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1W0</accession>
    <name>A0A1Y2B1W0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_588706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1W0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1W0"/>
    <dbReference type="InParanoid" id="A0A1Y2B1W0"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013050580" description="Galactose oxidase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="815"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="905"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="853"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="936"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY28477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="112773" checksum="E3AA9ADE4EB7BFDC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2J4</accession>
    <name>A0A1Y2B2J4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_559258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2J4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2J4"/>
    <dbReference type="InParanoid" id="A0A1Y2B2J4"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF145">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011835351" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="50"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="199"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="454"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY28956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="524" mass="57931" checksum="50DCB2ABF07055A3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2S1</accession>
    <name>A0A1Y2B2S1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_559200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2S1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2S1"/>
    <dbReference type="InParanoid" id="A0A1Y2B2S1"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="68"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY29129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="601" mass="67850" checksum="C2C89E342DEF9E48" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3Z8</accession>
    <name>A0A1Y2B3Z8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SEN1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_467452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3Z8"/>
    <dbReference type="InParanoid" id="A0A1Y2B3Z8"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="7">
        <location>
            <begin position="94"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase SEN1 beta-barrel" evidence="10">
        <location>
            <begin position="1334"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="8">
        <location>
            <begin position="1476"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="9">
        <location>
            <begin position="1758"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1170"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2031" mass="225345" checksum="DF3B4947FA7066BA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4P6</accession>
    <name>A0A1Y2B4P6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_558930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4P6"/>
    <dbReference type="InParanoid" id="A0A1Y2B4P6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="243" mass="27228" checksum="24CD0C9A207D7FE1" modified="2017-08-30" version="1">MTTLRTTTHDEEIFNSLVKWSIRTAAAHVGPYAAGFLYTLKHEDHNGSSSHPSPSTTFVFLAGIEHENHLYLENYPFETLLVSATDFPTSTIRLGHTKIDSILKDEEVSALSTGVAHTSIDRSTDKTIILANWDEFNNDKKLIGIKWDSDVQQCFQNHTRLPPQFSTMLSEDMPGSSQLPRLDQYSRTGQTSSRTGIGGLYKTLKDVWIHRYRLKKHSNNQSDADSTNNTGPTENTVQTGNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6S0</accession>
    <name>A0A1Y2B6S0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_587798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6S0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6S0"/>
    <dbReference type="InParanoid" id="A0A1Y2B6S0"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="969" mass="107920" checksum="79FDEA872B897F51" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7J9</accession>
    <name>A0A1Y2B7J9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_558500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7J9"/>
    <dbReference type="InParanoid" id="A0A1Y2B7J9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="140" mass="14915" checksum="F247461C310727F3" modified="2017-08-30" version="1">MTETLATLELWSRVTVGTVLLGVTACTLLGYSLRNTSPAQPNLTESQRCTLLSFECLTANARGGRSSGDSASCRKHRLLCEPPEPPESHAGANDDEQLTQAAESSSTDKIPTPEITIVETETSPPSEPPTSDGMMGHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8H2</accession>
    <name>A0A1Y2B8H2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylulose kinase</fullName>
            <ecNumber evidence="6">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_587650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY30996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8H2"/>
    <dbReference type="FunCoup" id="A0A1Y2B8H2">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B8H2"/>
    <dbReference type="InParanoid" id="A0A1Y2B8H2"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000275">
        <property type="entry name" value="Putative xylulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="7">
        <location>
            <begin position="304"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="617" mass="67325" checksum="C63E7F8AEB7B859B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8V3</accession>
    <name>A0A1Y2B8V3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_527184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8V3"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8V3"/>
    <dbReference type="InParanoid" id="A0A1Y2B8V3"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="26968" checksum="F0B1DBF185A8F25C" modified="2017-08-30" version="1">MSAIATKAAQKLLKGKASAWAPSDPHYVEEVDPRSGKIKRKERPIPPGLSKRDQKALRKIRRRAHRLDKGMNLCGFRVGYTFFIGIVPGLGDVVDATLNYTLIVKPARKLDIPDELLTKMLFNNAISAGLGLVPVVGDVGLAAWKANSRNAHLLEAYLTIRGQEHLATLGQGPSAITDSTTQGAHPEEVRGVFVPGSGMDGDATHDDEGKGSGGGRWGKNKSKGKNDAVVGNGTGQGGQYGAVAPGSGTGAGKTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9B5</accession>
    <name>A0A1Y2B9B5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_92165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B9B5"/>
    <dbReference type="InParanoid" id="A0A1Y2B9B5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="498" mass="55144" checksum="F5CB2999AEF009CB" modified="2017-08-30" version="1">MSYSSYQNQHLQPAWDNAPPMPAQNLPRHPGGQFPPRFPHDYHPRAPPRSSFQFDPRFQPSTSVPNPSVRSDDIKVLVEEDDGGWERGYPAHQQVHPSKQSPNQMTKPVHQMPPDDVHHDHAHPLEHSKTDERNARLDKVKQSVPMDHDMENSQSSHFESAVNQNSKVVESQHSDFIQASQAVDHAPESPASAATQDPQNTPSSINVSASSTRVDSANLSSPHANLASDSHDKTTMPNGSNTYRQSPLVEVPTWRGPVPGSFQRAIAEVDCDSNRVVVPHPRQWGASSLPQAASVSQNPIGGDHRSENHVVDSITSPASRQGDWDHNARLQNWADSVQTLSPPEAVDPPSTVLRTPSPPDRPDSVPLAPRPVTAYVSEDEESIPLDPGSQTKDDDQSPKSPAVLSVSAEVNGQEITLDKEVDEQSPERTGVLRRNRFERNSSIRSSSQFHAHRGGAFRGPRQNRLADDRGAYYKRPPHPIYHPKFADRRLLIPLLNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAL5</accession>
    <name>A0A1Y2BAL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_558037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAL5"/>
    <dbReference type="InParanoid" id="A0A1Y2BAL5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="252" mass="27950" checksum="DE80A9A6238FF15C" modified="2017-08-30" version="1">MTTSIITSPRTSSTQSPSQLGPPLTFRPSFTTTTRICAPSPLRESALARSPPYSPSSREYYLSPSNPFSFCRQPVFSPNRRRKVHFSPPTATHLRLHSRLVPPPPPTTYSLAWCRLKAFLEERCNWTAEEIWEAAVQAVFWMCLVIFLTCICGVGYPDKIHIDTARPPIHGHVPSRAFIKPSPAVGYQMKIHSVVGGWSDMDHGIGIGAIQEELGGRSTLGVLSQRAEGDIGMVGPLGIWEGIWEGERKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBC9</accession>
    <name>A0A1Y2BBC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative SAC3/GANP domain protein associated with nuclear localization of protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_465384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBC9"/>
    <dbReference type="FunCoup" id="A0A1Y2BBC9">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBC9"/>
    <dbReference type="InParanoid" id="A0A1Y2BBC9"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="295"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="483" mass="53999" checksum="C71C9D632F090927" modified="2017-08-30" version="1">MSSSWPPQLKQWVQDCLAKATPSNKTAVNNELKQILFRAHADGTINTTDWNTVQLASLKAQTARTTYVPPPPVQSYVTPHPPPSSTYASAFPPLADKSRNDAAHESKGTIHADFPSAYQFKSNKDSEMLARRAARFAGTDDSGPKATPPPPIGVGGWFGGGNDDDDAPSGGMVPIQVGLKKMRGLGGMGYARDIVEVDPNVINWDRFTIKGTNTKLEKRYLRLTSEPSPADIRPLHVLQQTLQLLKRKWKDEHNYAYAVDQFKSVRQDLTVQRIKNEFTVEVYEIHARIALEAKDLGEYNQCQSMLRQLYELGIKGHPQEFLSYRIIYLLHTRNRSDMAALLAHLTPAEKADPGVHHALQVHASLATSNYVRFFRLYNSAPNMTGYIMDHFVERERMSALAIISKAYLSLTLPYLTTTLAFDSDEETDSFLSSHNAAIYTNATAPLPPPTPLHERLWDCKKAHPACLRGTEKYRVVDLKGQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBD8</accession>
    <name>A0A1Y2BBD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13 14">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 13 14">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_465794</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 13 14"/>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBD8"/>
    <dbReference type="FunCoup" id="A0A1Y2BBD8">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBD8"/>
    <dbReference type="InParanoid" id="A0A1Y2BBD8"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="16">
        <location>
            <begin position="9"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="15">
        <location>
            <begin position="195"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY31405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="395" mass="42413" checksum="BE7734B4C0467018" modified="2017-08-30" version="1">MAYQATATAPVNIAVIKYWGKRDTALILPTNSSLSVTLDQDHLRSTTTSRADAAFQGPDRLWLNGKEEEIKDGGRLWVCIKELRAWRREMEESDSALPKLSEWPLRIASYNNFPTAAGLASSASGLAALVSSLSTLYALPQSASELSRIARQGSGSACRSLFGGFVAWREGTSPDGSDSLAEQVEPASHWPEMQALICVVSDAKKGTSSTSGMQRTVATSPLLSARLAGVPARMKAMESAITSRDFPAFAELTMADSNQFHAVCLDTSPPIFYLNDVSRAIIALVEEINRANTTPIAAYTFDAGPNAVIYAQAKDMPVIITAVKKFFPTEQEFTDPLKVGEAPLPQGFNDTVVRHGGWEKGAVKALIHTRVGDGPRVLGESDSLLGENGLPKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBF5</accession>
    <name>A0A1Y2BBF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_524374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBF5"/>
    <dbReference type="FunCoup" id="A0A1Y2BBF5">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBF5"/>
    <dbReference type="InParanoid" id="A0A1Y2BBF5"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="258" mass="30105" checksum="F3247159D7DD768A" modified="2017-08-30" version="1">MADHQAILDEEFEVLESIFPDELEKVDERHVKIRVEPEEPSTSYPLSVYLAISYPSTYPDTIPELSFETIDEESGELTEEESEDILSSLQTLAEESIGMAMTFTIASAAKEALSGIIAQRIRKAQEEDDRRTKEYEEIEARKTRGTPLTPEGFEKWKRSFQRELEEKRAREEEDRIRSMPQKEKEEWKKRRDRPSGKQLFETSHTLATSDEALYEEGVTEVDMSKYTRAEREAERRREEEEEERRRRGLVAGDESDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBM6</accession>
    <name>A0A1Y2BBM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_464790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBM6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBM6"/>
    <dbReference type="InParanoid" id="A0A1Y2BBM6"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="131"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="359"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="570"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY32231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="864" mass="98602" checksum="B753EE75B3E51DE7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBV1</accession>
    <name>A0A1Y2BBV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_586986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBV1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBV1"/>
    <dbReference type="InParanoid" id="A0A1Y2BBV1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="802" mass="84530" checksum="6F5463CD68EB36FC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBZ5</accession>
    <name>A0A1Y2BBZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_446054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2156690at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25068" checksum="3BCA410C3EA0C1E6" modified="2017-08-30" version="1" fragment="single">WTLEKFILSFSVLSIFGYGLAGLIWSMLILLRINDDTDVTIVTDPDIVIFLTIASLLCIFSALIGLTGTLLNSRPILSFYNLLLWPTLLSMCLVGYTSYKRGNLQLDRKLNQMWSQILTDEERLRIQNSLTCCGYYNPLHDATYSKKCYPRTTLPGCKGKWYRFEVSRLHDFATAAFSTIPCHLLNIVVAILCSNHVNRTFGKGLTPPQYRLKVSDVRANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCF8</accession>
    <name>A0A1Y2BCF8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_504247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCF8"/>
    <dbReference type="InParanoid" id="A0A1Y2BCF8"/>
    <dbReference type="OrthoDB" id="2562717at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="233" mass="26018" checksum="D6979DC563D9143C" modified="2017-08-30" version="1">MVVSILLLKMLDDDLVSRLIYLPEEFLLIFNNNNNNIPNPITYNILNNNVLLTTNSSNTNTNSNNSSNTNNSSNNTNNIIYSTSINKQGSTPFAERPPQLPISNSHTNTLFRDPFAVSSNPNPNPNTNPNTNTNAYPYSSQSQNQSQRGYIILQPAPAMISPGQTEFLHHPEMEMETEHETYETLVGLGYSLNKLRAPTPWIRGHAEDAEWLNEDDVSDITDLEGRLKGVNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCL7</accession>
    <name>A0A1Y2BCL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y2BCL7">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCL7"/>
    <dbReference type="InParanoid" id="A0A1Y2BCL7"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="172" mass="18968" checksum="C34BAC53E4FC30A3" modified="2017-08-30" version="1">MSIRLPECHSVSSSCELKTSAIAEYVASVTLESGLMPTDPGEAAQVRMWLHICEAEIMAPLSVVNKGLIHLIPYDDEMSDGILQTVHRRLTNINNWVSDREYLVGGRFTLADLTLASVLGHGYAKFFDKAWQGAYPYALEYHKRILADPKLNGALGEPVLVGKAAVWKPKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD55</accession>
    <name>A0A1Y2BD55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_557615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD55"/>
    <dbReference type="STRING" id="71784.A0A1Y2BD55"/>
    <dbReference type="InParanoid" id="A0A1Y2BD55"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="103" mass="11167" checksum="DB2664A419BD11CF" modified="2017-08-30" version="1">MTFGKEFTTAVEQKQIAQQDAERAKFVVEKAEQERQAAVIRAEGEAEAANTISAALNKAGDAFVQFRKIEASREIASTLAQAKNVTYVPSSSGNLLLQVPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD92</accession>
    <name>A0A1Y2BD92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD92"/>
    <dbReference type="InParanoid" id="A0A1Y2BD92"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="367" mass="40334" checksum="D0AAB0768AE9BA38" modified="2017-08-30" version="1">MSGVTIKVTSGAPGVSSQADDDSDQGDYGELDPEDYGELDPKYYGELDQDDYRVSDQEDHTPPNNSSDFPSPHSLHISVCDPRVFDSSAFELPLRYSVRIAGDGTDPDGHTYLSTFGYVPNKSDSPPTIADHSTTVPPPTLVAPPTTNNSQLPWTAEIEEKATRELRHFEADIRNIRVFASATVIFPPGKEPPDSITASFPELSSEAKDAEIFTRFCLRHADESEPINKEHAHDPDSYNTWDHPWVGTFRLPPPLPNREANATDQQDDSTAVTVARESIRIQIPLMEQKHSDAVNSGDSTNDRVNPIPYYDYSQEGHEFLPSQKQSLTAGNDTFKGLVHGGISYLLVNKGPFLGTSTPSGFFVPING</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDE0</accession>
    <name>A0A1Y2BDE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ER to Golgi transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_464140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDE0"/>
    <dbReference type="FunCoup" id="A0A1Y2BDE0">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDE0"/>
    <dbReference type="InParanoid" id="A0A1Y2BDE0"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="199"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="420" mass="46898" checksum="125FBAB57F55E8A2" modified="2017-08-30" version="1">MYEPHLVNHANDHAANDNVSSLMEELDKLAPIKSFDAFPKVQSTYVSQSRRGGALTAIVGIIIFLLVLNDLGEYLYGAPDYSFLVDHQLEKDLQLNVDLTVAMPCHYLTIDLRDAVGDRLHLSDDFVKEGTTFKVGKATSSRIVAPTAQSASEIIASAKRRTPNQRRSFAGIRRLFSPRPKKSKHSSYRPTYDKVEDGPACRIYGSVEVKKVTANLHITTLGHGYMSFEHTDHTLMNLSHIIHEFSFGPFFPAIAQPLDLSLEVTDQPFTIFQYFLRVVPTTYIDASRQRLVTSQYAVTDYSRSFEHGRGVPGIFFKYDLEAMALTIRERTTSLYQFLIRLAGVVGGVWTVASFGLRVFNRAQREVTKQTDKREVIPSSLPSLSPGMDASSSFGGPSMSRTASWRSGGRSSPMLGEWKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDJ1</accession>
    <name>A0A1Y2BDJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamB/YcsF family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_557462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDJ1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDJ1"/>
    <dbReference type="InParanoid" id="A0A1Y2BDJ1"/>
    <dbReference type="OrthoDB" id="5295431at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11665">
        <property type="entry name" value="LamB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29013" checksum="22DE94DD64D36ACB" modified="2017-08-30" version="1">MVNTSTTPLIAHRLTRVEINVDCGEAFGLWEGGPDEELMPMIDAANIACGGHAGDPVIMRRAVALAKKYGVKVGAHPGFPDKAGFGRRRLDMSAEQAYAEMLFQVGALKAFLDEADVPLNHIKPHGMWYIMMQNNEDVNDAAMRAIAHFKVPVYGLPNTLHESGAKKYGIPFIPEAFVDVNYTTEGVLLGVPGSRKMSPEEIYVATRSLGKEGLVPSVHHVPVDVGVRGKPFTLCLHSDFKGCRENVAAARRAVDEVNKELYSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDW2</accession>
    <name>A0A1Y2BDW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF 4e-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_326841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDW2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDW2"/>
    <dbReference type="InParanoid" id="A0A1Y2BDW2"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="545" mass="57953" checksum="2DBFF0312CA2C704" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BES8</accession>
    <name>A0A1Y2BES8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_463850</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BES8"/>
    <dbReference type="FunCoup" id="A0A1Y2BES8">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BES8"/>
    <dbReference type="InParanoid" id="A0A1Y2BES8"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="241"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="680" mass="76157" checksum="E15F36F11C14B933" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFC8</accession>
    <name>A0A1Y2BFC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sfi1 spindle body protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_520411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFC8"/>
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        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFC8"/>
    <dbReference type="InParanoid" id="A0A1Y2BFC8"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="321"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="924" mass="107636" checksum="0FB818D391E406B4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFY2</accession>
    <name>A0A1Y2BFY2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial protein Pet127-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_518873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y2BFY2">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BFY2"/>
    <dbReference type="InParanoid" id="A0A1Y2BFY2"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="809" mass="89351" checksum="7B9D94586ED7FF5C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGL5</accession>
    <name>A0A1Y2BGL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain binding protein 11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_517890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGL5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGL5"/>
    <dbReference type="InParanoid" id="A0A1Y2BGL5"/>
    <dbReference type="OrthoDB" id="205569at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12622">
        <property type="entry name" value="NpwBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="444" mass="47873" checksum="2B3D1D7D8E26E4E5" modified="2017-08-30" version="1">MAKSKNANPADAYRKALKAKEVKKNKEARKQARESQTIKQDTRDIEREIKSLKDAERQKPLSAFDAERLKSLNTELAHVIKTKEAYVKAHPEARDRVFKTGAHSDRPKRDGDGDEDGEGKQDMSHLYDENGRLRDPTRSIYFDPVYNPWGVPPPGMPYRERTPEESESEEDSEDEDIVMPEGPPPGADDDDEDSDDSDDIPLPEGPPPPKQLPPPPPVPPAGPSGWGAGAPPLHLPPRPPFGVAQPMGMPPFHAQPQMPFQPQSPAQYGFRPPSHRPPRPPPNVQDPLSDAPTQTYQGYRAAKHDLPVRPSAGSSTATAESPASSSLPAKPAPSAASLASATISAAPVLRDLRKEATAFVPRGVKRKAARPTPGGVSVNAAPGRGEVDEDGDERLPGKENGGGLLGKLQGVIGDLRDSGREKEGKAGAADDDYQRFLEGLGELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGT5</accession>
    <name>A0A1Y2BGT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Heterotrimeric G protein alpha subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_563758</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGT5"/>
    <dbReference type="FunCoup" id="A0A1Y2BGT5">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGT5"/>
    <dbReference type="InParanoid" id="A0A1Y2BGT5"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="174"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY34018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="362" mass="41036" checksum="681066A06E233727" modified="2017-08-30" version="1">MGCSQSVEDSAAKARNQEIEEQLKRDRANLKNEIKMLLLGAGESGKSTVLKQMRLIYNRPYDAEERDSYREIVYSNTVQSMRVLLEGVALMGVAIEPSNQSRWDAIMSAPTSIEGDVLAPELADAVKGLWQDEGIKKAFIRRNELQLNDSAPYYFDAITRIAHPSYMPSDQDILRARVKTTGITETHFKIGELTYKLFDVGGQRSERRKWLNIFDSVTALVFLIAISEYDQNLYEDETVNRMMEAMTLFESVANSRWFTKTSIILFLNKIDLFRVKIQNSPLNRTFPEYRGGNNYDAACAFLLEKFVGLNKNPSKSIYAHYTDATDTRALSFVISAINDVIIQSKTSKADAELVNLRDCGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGW5</accession>
    <name>A0A1Y2BGW5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_518895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGW5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGW5"/>
    <dbReference type="InParanoid" id="A0A1Y2BGW5"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="786"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="846"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="956" mass="106239" checksum="9665E2F4B3E66CE6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGY5</accession>
    <name>A0A1Y2BGY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_503730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGY5"/>
    <dbReference type="FunCoup" id="A0A1Y2BGY5">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGY5"/>
    <dbReference type="InParanoid" id="A0A1Y2BGY5"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY34071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="368" mass="39681" checksum="E0B46FD42F3DA1A4" modified="2017-08-30" version="1">MPNSHPKIKVGVLGATGTVGQRFIQLLATHPYFVIHALGASSRSAGQEYAQVTKWKLATPIPVFVRRMIVQECKPDAEGFSECGVVFSGLDHDVAGDIEFAFRAAELIVFSNAKNYRRDPVVPLMVPLVNPHHLPVVRHQQTTLSPPTKKGYIVTNANCSTTGVVVPLAALEKAFGPLETVMVTTLQAISGAGYPGVSSLDIMDNVVPYIGSEEEKIEWETSKILGGVNDDGKGFDHHAHAPLKISANCNRVPVIDGHTACVSVKFRRETPPSLEDIRKAFADYTCEAQTLGVPSAPPQAIVVHDAPDRPQPRLDRDLHNGACVSVGRIRPCGVLDVKFVCLVDNVRLGAATSSIMNAEIAVERGYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHD9</accession>
    <name>A0A1Y2BHD9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IID, 31kD subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_516733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHD9"/>
    <dbReference type="FunCoup" id="A0A1Y2BHD9">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHD9"/>
    <dbReference type="InParanoid" id="A0A1Y2BHD9"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="203" mass="22250" checksum="91275AC44FD594CC" modified="2017-08-30" version="1">MTTAPRPLPRDGRLIALILASKGIEDADERVIHQLLDFTYRYTADVLQSAQSLADHAARPGASKIEAEDIELAIDLRKRSEFFEPPPRDYLATLAHDLNSQPLPILPETFDILRLPPPHHRLAEVNFDIVPEAGLVLDDPNGGGASGSEDDDEDDDEEDDDEARTEDGDRVNGAISDDAAGSDDEMEAVPIAAPVRIEEDYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHG9</accession>
    <name>A0A1Y2BHG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_517931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHG9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHG9"/>
    <dbReference type="InParanoid" id="A0A1Y2BHG9"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="36"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY33957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="357" mass="38732" checksum="3B887642F44433D5" modified="2017-08-30" version="1">MQDQNAVGGPSRIPYKPRHPFVSADNRPERSDGVFRVLVISTGSVASIKIPDIVGALSKDAGIAVQIVATPPSLHFYSQETVDAAVRSELSHNSDDQVMGEGSGQDVGVKVWKDADEWSDWKKVGDPILHIELRRWADLVVVVPCSADFLAKIAGGLSENLALSVLRALTPSTSVVLCPAMNTHMYQHPFTAKHLQIVQNELNYLVLGPQGTGKLACGDDGPGKMTDWREIVSIIQDFAVMFRQNDFKIPTNATDRAAALTPKSNPSVRPSTFRVPWSTPSNLDKPLPSPKTSATPDFDDFPPTMADFFVAKPGLPITPGVAGQEGADTTRTTGVELRKVCSGTGTDSKVWKRWWYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHJ6</accession>
    <name>A0A1Y2BHJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_586187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHJ6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHJ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BHJ6"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="239"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="809" mass="87147" checksum="81C83A53907B977F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHS4</accession>
    <name>A0A1Y2BHS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_517789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHS4"/>
    <dbReference type="InParanoid" id="A0A1Y2BHS4"/>
    <dbReference type="OrthoDB" id="2569217at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="73217" checksum="F7C44E8222766675" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIA1</accession>
    <name>A0A1Y2BIA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bud emergence protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_517407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="548867at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
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        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIC3</accession>
    <name>A0A1Y2BIC3_9TREE</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Naematelia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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            <end position="127"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="1"/>
            <end position="10"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="ORY34320.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="163" mass="17967" checksum="C7D866407DC4D6EB" modified="2017-08-30" version="1">MTALSSASLSPLRPTTYNPPHSSVYHPVLSPPPTAESEIPMFYRHHQPPMHSAPPPLRRFGSSGNLHQQHAFGPDTRPELKRRSLSPDIMARPSNLPPSLAALRITRPRSEAPRLPSFDTPDQDITMDGSWAERTAAATDPARFRKSPIPRLSMVPVINQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BIR1"/>
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    <dbReference type="OrthoDB" id="2576623at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012508322" evidence="2">
        <location>
            <begin position="18"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="384"/>
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    </feature>
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        <location>
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            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="684" mass="68452" checksum="E2BD790B0B4E1F9B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIS7</accession>
    <name>A0A1Y2BIS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_513988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIS7"/>
    <dbReference type="InParanoid" id="A0A1Y2BIS7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="259" mass="28716" checksum="BB9F86816F2A2FA8" modified="2017-08-30" version="1">MDTLFSNPLSTMADTPLTRMLDTLFPTTTPTCILPDDQNWKVSFSVPHTDGSLVSIDHLCDHVVRQTENVSGGPNSDISIEFNTLPTSQDGYDSHLIRSSTDVIMHYQHLEATKTCDTRVLLLSKVTRIDYSGKTVTIKRGSFTPGSFVTETEPESDKQLFRPESMVSRIRAPASPVWDSTRTTHHKPSNPEGKDHAYHILAESKFSGWIEEPVLVDQRQSVIGFYNWKGTVIVALAVMATSTKSAEFLGGGYTCQCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIY8</accession>
    <name>A0A1Y2BIY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_125853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIY8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIY8"/>
    <dbReference type="InParanoid" id="A0A1Y2BIY8"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="287" mass="30166" checksum="C87AF6685C4A18B6" modified="2017-08-30" version="1">MSSYRADALFSVKGKTVIVTGGGSGIGKGMAAALAINGAKVIICGRRVEPIEETAAELNAAAKESSSGGQVIAIQADVSTKHGITDFYNKCEHIIDKLDYLVNNAGFSSNWKDQSPITDPLTLAKKLFSIDDVDFANMTAIHVAGPYLLGVKFIPLFQKSADPSICNITSIASVFLNRAVCEFSYAQSKAAEAHMTTLMAAALQPFKIRVNSVCPGLFPSGLTTTSDGKLYSLLVGQLKNIPKGREGLVEEMAGPVMMLATPAGGYINGANLVIDGGWVLNSSANDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ32</accession>
    <name>A0A1Y2BJ32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_458411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ32"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ32">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ32"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ32"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000024">
        <property type="entry name" value="probable tyrosine-protein phosphatase At1g05000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="201" mass="22924" checksum="8DE91A550DE3D7E3" modified="2017-08-30" version="1" fragment="single">LVPPVPQPLYLPPPALPDVEDDLVPPENFAVVSGGVYRCGFPMKRNFRFMETLRLKTVLTLVLEDYPEANLKWCQSQDIQFMQFGIPGNKEPFDNIPEDVICAALVQILDRRNHPILIHCNKGKHRTGCLIGCVRRLQSWSLTSIFDEYRRFSSPKSRAVDQQFIDLFDLSPVWESVMSSGGGLENLPRWGMLTLPRGRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJB6</accession>
    <name>A0A1Y2BJB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_461826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJB6"/>
    <dbReference type="FunCoup" id="A0A1Y2BJB6">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJB6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJB6"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="261" mass="29631" checksum="8F835E212AE4FA70" modified="2017-08-30" version="1">MDDISTGSESDYSNSWISWFLSTKGNEYFAEVDEEYILDRFNLTGLNGEVVQEYSRALDLITDSLDDEALDDDLREVVETSARFLYGLIHARYIVTSRGLQKMLEKYRKADFGRCPRVYCYSQPLLPVGLSDIPYQKAVKLYCPRCEDIYSPKSNRHGSIDGAYFGTTFPHMLFMVYPQMIPAKGQPVGSSGVAEVKREGPSSVGSVSTASAATKAERFEPRIFGFRVHEEARLSRWRGARRDAQTARLEQLEKEQTQPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKH2</accession>
    <name>A0A1Y2BKH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_117035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKH2"/>
    <dbReference type="InParanoid" id="A0A1Y2BKH2"/>
    <dbReference type="OrthoDB" id="2562784at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="610" mass="66050" checksum="AA6D21E80C0B8DEB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL27</accession>
    <name>A0A1Y2BL27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_508926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL27"/>
    <dbReference type="STRING" id="71784.A0A1Y2BL27"/>
    <dbReference type="InParanoid" id="A0A1Y2BL27"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="584" mass="65506" checksum="2B5247F5EC8014CE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL62</accession>
    <name>A0A1Y2BL62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide exchange factor Vps9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_563092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL62"/>
    <dbReference type="FunCoup" id="A0A1Y2BL62">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL62"/>
    <dbReference type="InParanoid" id="A0A1Y2BL62"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="177"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55316" checksum="EE2D37C58EA2CDFB" modified="2017-08-30" version="1">MDGTQSQQLAEPEPVDNLTTPAPRSRPLTPGAPPPNPPGLAQDTPDKPGESSASGAARAELATPVANAEPNEVPFNFAGFLKDLRAKSAEPVAKYLKSFLSNFAKKPFTVNEQVKLIHDFLEFISGKMRQVEPWQSQPVPEFENALEAMEKLVMNRLYNYTFTPQLVPSQPITTDDLERDAVFAQRVRLFGWIRERHLDVPEGDASQGFLGFAEQELLKINHYKAPRDKMICILNCCKVIFGLIRHAHGAEAASADTFVPILIFVVLQANPENLLSNIEYINRFRSASKLQGEAGYYLSSLSGAISFIETMDASSLSNISREEFERNVEDAIQELPPSPSATVSRPIASEMSPFSATTEGDEPARPLSFPSLDNTRRFFQRTGTQVSDVVSRPLGAIGKIFDGIQKETPERRPSTPESPSQRFAQLEIDESRSRSGTPEVPIPDFQSTLEQSQEAFTQTRHANVQTLHQMFPDLDEDIAEAVLEGCGDDLGLAIDRLLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL74</accession>
    <name>A0A1Y2BL74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_510230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL74"/>
    <dbReference type="FunCoup" id="A0A1Y2BL74">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BL74"/>
    <dbReference type="InParanoid" id="A0A1Y2BL74"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY35513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="205" mass="21259" checksum="20BE2C843E906F6C" modified="2017-08-30" version="1">MSAMDIDKPLDEMIKAKPRGARRGGRGGRGGARGGAGVATSTSARARYATAVPKAAGATPAAKPITAEASKIIISNLPADVTEAAVRDLMQSTVGPTKSVQLTYTAAGKSTGTATILFKNKGDGNKAYAAYNNRMIDNQRPMKVELALDPNQMVSLASRVAPAPTARGAPAKRGRTPRPRNPRPAKKTADELDAEMAAYKTDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLX9</accession>
    <name>A0A1Y2BLX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_26993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLX9"/>
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</entry>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
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                <person name="Sullivan W."/>
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                <person name="Daum C."/>
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                <person name="Spatafora J.W."/>
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            <strain evidence="3 4">68-887.2</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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    <accession>A0A1Y2BMC1</accession>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012260071" evidence="1">
        <location>
            <begin position="20"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="269"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="708" mass="78519" checksum="F657383E08038049" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMC3</accession>
    <name>A0A1Y2BMC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_512985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMC3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMC3"/>
    <dbReference type="InParanoid" id="A0A1Y2BMC3"/>
    <dbReference type="OrthoDB" id="2560689at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012937540" description="Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="54718" checksum="DAFD0D92AFEEA802" modified="2017-08-30" version="1">MAPVLVRRVIFLLPFLTLALLTQHPLTSPYLSALYSSTNEEANIRQADSHAAALEPYFPSDRPADLWGWDNYKHYTESEMRKLAVCITTNTCRENQTTVVIYGHIHAHWAMYEGYGAGEGVWVKSVDDTLRKFGYTILHARDDWRYIWYIYNQIPDLVQYIFAYPHGQGKFDDYRKTEKRPYGIPAWKLFVYNYMPGHKASVVGDHWNVNSESGFARDSIDHLERSWTYLPYTITIPSTPPHIPTNERPPRIWILAKYIRYFYPQSNPAWPLDFFARASLDLQAEFPGFEFTAACKDDRNEQEKEDKPMQLPDGIRVVGVNLKHQEFEREVALSRGMLGIGWPTESPSPHNALSLGVPFLNPYDLNDHPSSKDADRGSWRNSQHHGMMYLDPPYVYHIKRNNYTSFLEGIRQALRTPIEQTQLPWTVRERQEEIVGDFMSTDWKSRAEWILEQRKAGVETQERAGEIFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMH7</accession>
    <name>A0A1Y2BMH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_568839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMH7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMH7"/>
    <dbReference type="InParanoid" id="A0A1Y2BMH7"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF2">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="358" mass="38848" checksum="3196FEDBF934C8CD" modified="2017-08-30" version="1">MINPLVFLSNMPAPMLPIVKVAACHAAPVFLDTAATVQKGIQLIGEAAQAGADLVVFPEAWIPGFPLWSALASPTMNHDLFISLAREAIFVDGTEIDQLRAACKQYRIFAQIGFNERSKASLGCLFNATILISDEGVVLNHHRKLVPTFFEKLIWAPGDGAGLRVVETRIGRLGSLICGENGNGLARYSLMAQGEQLHVSHWPPIFPTRPPGEAGNFDLAGATRIRVAAHCFEAKCFGIVCASPLGAARDFLIQRDPSCAPLLEDVPQSSTMFLDPTGSQIGDELEGESEGIAYATFDLNKCIEPKQFHDFVGGYQRLDIFKLTINRTRHEPVVWEEDGRVQHNTVSAGFIPSAPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BN98</accession>
    <name>A0A1Y2BN98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_24616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BN98"/>
    <dbReference type="InParanoid" id="A0A1Y2BN98"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="244" mass="26934" checksum="4AE077A89960FADE" modified="2017-08-30" version="1">MMPQSSQSSTLVRPKALSQEKNSTMRSNPTVSTRPQLMTQSVGVNDTRPSKRPRLSPAKKPNTNAFAVPRRYAHSGGSQSLHKAASRKDEKALLDDLMAGLDASMFENLASSPAKISTSQVKPRTPLAVKHEVQISTTSRTPVRFNANVKSAKEDALPCSVKLEHKNETNEEAIVDIKTDKRKARSLSPVFVKAEPKVDIADDELYDFDFDLGDLSGLNDDELLQPQQVQVRAATELLRQLRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AC00</accession>
    <name>A0A1Y2AC00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_571435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000151">
        <property type="protein sequence ID" value="ORY20089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AC00"/>
    <dbReference type="STRING" id="71784.A0A1Y2AC00"/>
    <dbReference type="InParanoid" id="A0A1Y2AC00"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="122" mass="13546" checksum="5DDF942ED1B737FD" modified="2017-08-30" version="1" fragment="single">KETTTSSTHEPPSSDKETTSSTEINGTSQNFVPACGVGEWEPIWLGRADYLENGVERDWSFRDVVLRDGEVIEDNGDHGPHPPQDEIPAGLSPGMERFLRRGIPQANVFVPEIQTLKNKGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADQ8</accession>
    <name>A0A1Y2ADQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_451871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000129">
        <property type="protein sequence ID" value="ORY20636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2ADQ8"/>
    <dbReference type="InParanoid" id="A0A1Y2ADQ8"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="250" mass="27087" checksum="00E1EE82D7E9D09B" modified="2017-08-30" version="1" fragment="single">PCDTNNDHLDADSKAFVTDCDSFGYCAINGTCLPRQCRRDEYILSSLVDANSPIPPLCPPGSFCPDSASGCLALVPVGGKCQLNRDDECQPPIQNIVSSDPYDQMQASAAICLLGTCMYGNATLGSACISESTTYVGYDISGMSFSNQVVRDNCIENQGYCDQTQNICLALKSLSSSCAADRECQSYNCNSNNECVIPPESAIHVARWIYVLVGLGLSTAMATILAILILMHNRAQNAHRIMLEEYYKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE52</accession>
    <name>A0A1Y2AE52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_508643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000143">
        <property type="protein sequence ID" value="ORY20235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE52"/>
    <dbReference type="STRING" id="71784.A0A1Y2AE52"/>
    <dbReference type="InParanoid" id="A0A1Y2AE52"/>
    <dbReference type="OrthoDB" id="2597040at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="783" mass="86915" checksum="755CF5FA057D881F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFB8</accession>
    <name>A0A1Y2AFB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_553954</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000114">
        <property type="protein sequence ID" value="ORY21293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFB8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFB8"/>
    <dbReference type="InParanoid" id="A0A1Y2AFB8"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY21293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="630" mass="71344" checksum="B6F2E86ECB0BF520" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFW0</accession>
    <name>A0A1Y2AFW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_554184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000117">
        <property type="protein sequence ID" value="ORY21160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFW0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AFW0"/>
    <dbReference type="InParanoid" id="A0A1Y2AFW0"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="5">
        <location>
            <begin position="259"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY21160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="391" mass="42319" checksum="FE26C9F6209DDF39" modified="2017-08-30" version="1">MGLLRRVLIIGTGGTIASEPTPGGYAPLRNDAFFRRIRQHPQLSDPDSLSSRSGTATPTFSSPVETVPVGKNIRYPTLRTPVLDEHGARVEYEILDLDRHLDSSEMTPAEYNIIASLLEENWDLYEGFVILSGTDTLAYTASILSFLFTNPGKPITITGAQIPLSQPRSDGWTNLLDSLYVAGVLPYAGVGIVFHHQVFHGCRATKTSPNLFNAFQTPCVPPLINLNVKITHQSRLPPRSSALPPRIIPLATSPTVISASIHPGITGTLLAAQIDAVPTCRAVILSAYGSGNLPISEEAGILGALRKAVDKEILVVVISQCPIPNVYPLYTQGRTLLEIGVLPGYDLTHEAAFAKLLWLVSRKDLTFKNRQELFQIPVTGEMSVEGGARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHH2</accession>
    <name>A0A1Y2AHH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_552417</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000099">
        <property type="protein sequence ID" value="ORY22033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHH2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AHH2"/>
    <dbReference type="InParanoid" id="A0A1Y2AHH2"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY22033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="270" mass="29728" checksum="4A790AF29B5249EC" modified="2017-08-30" version="1">MNVMTDVAFVFNPTHARWRLEDQSKQLPPFSLSQRRVCQPVIYNLLPLRSYVGPSVTTSSASKMTTQAPRESHFTLPLPQSDFLAHLEECISATESCSSTLQKGVERLEPGTKDLPRLTKILRNKHHYLLLPHPTIQSHTAALSTSLAPQIDALITKAENLVQGQSGRVDRLAERLSILQSARLPRSNPTPIVDTDKTVKSTGLGPERGDEQGTEGNQQSCKISHLEMKDLSVGQRRKVVMLRGKRERLEKEREKLLSGAGAGGGGGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AI98</accession>
    <name>A0A1Y2AI98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_501710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000097">
        <property type="protein sequence ID" value="ORY22194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AI98"/>
    <dbReference type="InParanoid" id="A0A1Y2AI98"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="453" mass="48581" checksum="0019BBF917DCD04B" modified="2017-08-30" version="1">MSDSELLQSSGGLASSLISQLESTAESLADGLFDLQWAIHEHPELAFQEHFAHKACTDYIEKQGFEVTRHAYGLQTAWKAVYEVGEGGPVIGFNSEMDALRGIGHACGHNLIAIAGIAAAVTTAHLLESRKISGKVILLGTPAEEAGGGKAYLLKRGAYDGMEACFMTHPGTQGYGSAISTLSCNAAFSVKYTGASAHAGAVPERGINALDAAVAAYSNIALLRQMLPDSFRVYDTIQGSEGWTANVIASESRLTVGVRCPTAKETYGTIDRVLNCLKAAALATGCQYEIRREALYFDMQQAHELDDYFTKVCTETWGHKGYTVGRSSSYASTDFGNISYHLPALHPTFSLPDSRAGDFPHSNTFASWTGSKSACEAAIQSAVSIAAVGTRMIVDRAWAKSVRDSWVRQMESIDGSETVSKIEKLVESFPLSPETSNAVCCGHDETNKHSNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ06</accession>
    <name>A0A1Y2AJ06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP/chorismate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_551287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ06"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ06"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ06"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="157" mass="16956" checksum="2F579A96E31266D8" modified="2017-08-30" version="1">MLSTFTRSLPQLVSRTSIRSFSRSHIIMSSPYTVVATDKAPAAIGPYVQAVKYNGLIYASGSIPLDPVSMEVVQGGIEEQTAQVFKNVSAVLSASNATPASVLKTTVFLKSMNDFVAFNKIYADFFGETKPARSCVEVARLPKDVLVEIEFVAVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ66</accession>
    <name>A0A1Y2AJ66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_551328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ66"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ66"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ66"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="806"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="934"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="747"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY22576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="996" mass="108391" checksum="EFBF03168409A783" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKP0</accession>
    <name>A0A1Y2AKP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_363446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKP0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AKP0"/>
    <dbReference type="InParanoid" id="A0A1Y2AKP0"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF5">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY23111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="420" mass="45510" checksum="278A7EC71C4E2D86" modified="2017-08-30" version="1">MSTSDKVRLYLLYLPAFVRFSISQLVFTFRSRLHAYSYSPTFSPKNVLILGGSFSGVHLATRLANMLPSGHRVLLVEKNSHFHYSFNFPRYSVLAGHEYKAFVPYSGLSGSAPPGALRVIQGTALNVSDGEVTLASGERVPFAYLAIATGSASPPPAKLVGTSKLDSCAELRAMQTRIRLANRIAIIGGGAVGVQLAGDVKSLYPGKRVVLVHSRTQLLPSFKSDRLHKYVLAALEGMGVEVKLAERPALPRTTQVEAGPIDLEFGDRKHETFDLVIPCTGQQPQSTVLSSFSPSVVSPRTGRILVKPTLQVAEAAHPNVFALGDVAETGGPKMARAGMVQAEVVAANIVRMILERRDSKRYVPESSEGALKLSLGTTDYIWFLGGGRRDILVPGKRKDVDMDPKEIWKHLGVDSGDMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALB3</accession>
    <name>A0A1Y2ALB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_359508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000080">
        <property type="protein sequence ID" value="ORY23353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALB3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALB3"/>
    <dbReference type="InParanoid" id="A0A1Y2ALB3"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="118"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="341" mass="37121" checksum="C32451054394DB10" modified="2017-08-30" version="1">MVKLAVLDDYPAISKAYFDTLPSSYAAKLDITVFTEAIPPSELAVTLAPFEIISTMRERTRFPADLVEKLSNLKYLTTTGMKNAGLDLPAFKDKGIIVTGASGPAIPAPAVTVQHTWALILDLASNVTRDHNATRNGHWLDATPLNTTLGGKTFSALGLGRLGAAAAKIAKLGFNMRVIAWSENLTQEKADQLAVRDGLPKGTYEVVSKERLFAEADVLSVHLVLSARSTGIVGHEELSAMKSSALLVNTSRGPIIDEPALLNALEKGKIRGIGLDVFDIEPLPLDSPWRTTKWGQEGRSEVVLTPHSGYTYEETLDGWWKETVDNVRRYIDGQEVSNRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALW0</accession>
    <name>A0A1Y2ALW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BCR39DRAFT_549096</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 20"/>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALW0"/>
    <dbReference type="FunCoup" id="A0A1Y2ALW0">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALW0"/>
    <dbReference type="InParanoid" id="A0A1Y2ALW0"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 14 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="204"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="14 15">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14 15">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="348"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="388"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="411"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="435"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ORY23541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="550" mass="58097" checksum="4DE33FE45196F583" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALZ5</accession>
    <name>A0A1Y2ALZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L32e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_548906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALZ5"/>
    <dbReference type="FunCoup" id="A0A1Y2ALZ5">
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    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ALZ5"/>
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    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="130" mass="14835" checksum="DCDB47703E7F5EB9" modified="2017-08-30" version="1">MSPAHIPIVKKRTKHFKRHQSDRYHSVKESWRKPKGIDNRVRRRFKGQLPMPKIGYGSNRKTRHLIPSGYKELLVHNLADLDLLLMHSNKYAAAIAHGVSSKKRVEIVARAKVLGVKVTNAAAKLRTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMF1</accession>
    <name>A0A1Y2AMF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_548683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMF1"/>
    <dbReference type="FunCoup" id="A0A1Y2AMF1">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AMF1"/>
    <dbReference type="InParanoid" id="A0A1Y2AMF1"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="104"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="57566" checksum="C0CC0AF38E466113" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANB3</accession>
    <name>A0A1Y2ANB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_548040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANB3"/>
    <dbReference type="STRING" id="71784.A0A1Y2ANB3"/>
    <dbReference type="InParanoid" id="A0A1Y2ANB3"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="893" mass="97987" checksum="B71EF8F9A792E413" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANZ3</accession>
    <name>A0A1Y2ANZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic solute transporter Ostalpha-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_548385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000074">
        <property type="protein sequence ID" value="ORY23937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANZ3"/>
    <dbReference type="FunCoup" id="A0A1Y2ANZ3">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANZ3"/>
    <dbReference type="InParanoid" id="A0A1Y2ANZ3"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY23937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="531" mass="60653" checksum="C4C9566763FCC05F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP07</accession>
    <name>A0A1Y2AP07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_548751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP07"/>
    <dbReference type="InParanoid" id="A0A1Y2AP07"/>
    <dbReference type="OrthoDB" id="2581860at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY23685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="659" mass="72999" checksum="725A1BE231F19C59" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2APH7</accession>
    <name>A0A1Y2APH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_595325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2APH7"/>
    <dbReference type="InParanoid" id="A0A1Y2APH7"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY24479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="527" mass="58534" checksum="AF18746E1D00884D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQT9</accession>
    <name>A0A1Y2AQT9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_449350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000066">
        <property type="protein sequence ID" value="ORY24587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQT9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AQT9"/>
    <dbReference type="InParanoid" id="A0A1Y2AQT9"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001153">
        <property type="entry name" value="Barwin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00967">
        <property type="entry name" value="Barwin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012801960" evidence="2">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Barwin" evidence="3">
        <location>
            <begin position="69"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="134" mass="14297" checksum="B7E87185BC9C386F" modified="2017-08-30" version="1" fragment="single">MFGKIFTALALVSLVAAAPVSPAAESSLEKRTSHTGRATWFDVGLGNCGWYSQNSDYVLAMSEAFYDENNGANCGQGVYLKNTANGNTAYAVMVDSCPGCSRDQVDLSPSLFKALASDGLGEGELTLTWHFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR81</accession>
    <name>A0A1Y2AR81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell division control protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_321343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000067">
        <property type="protein sequence ID" value="ORY24465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR81"/>
    <dbReference type="FunCoup" id="A0A1Y2AR81">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AR81"/>
    <dbReference type="InParanoid" id="A0A1Y2AR81"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY24465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="191" mass="21279" checksum="B18369DD9047AD4C" modified="2017-08-30" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDDPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVKEKWFPEVHHHCPGVPCLIVGTQVDLRDDQGHLEKLARQKQRPITTEQGDRLARELGAVKYVECSALTQRGLKNVFDEAIVAALEPPVVKKKNKCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARQ6</accession>
    <name>A0A1Y2ARQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="5">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_561147</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARQ6"/>
    <dbReference type="FunCoup" id="A0A1Y2ARQ6">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2ARQ6"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="12">
        <location>
            <begin position="33"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY25243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="639" mass="70544" checksum="AA9D1114408F3991" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARS2</accession>
    <name>A0A1Y2ARS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_485643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2ARS2">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARS2"/>
    <dbReference type="InParanoid" id="A0A1Y2ARS2"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="891"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1738"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2510"/>
            <end position="2670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2471"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2629"/>
            <end position="2686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2479"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2629"/>
            <end position="2662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY25251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="2686" mass="297599" checksum="841B0C5099CC5691" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARY8</accession>
    <name>A0A1Y2ARY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane transport protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_544426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARY8"/>
    <dbReference type="FunCoup" id="A0A1Y2ARY8">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARY8"/>
    <dbReference type="InParanoid" id="A0A1Y2ARY8"/>
    <dbReference type="OrthoDB" id="2499604at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY25349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="589" mass="64078" checksum="30ADFFC2F703103A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARZ7</accession>
    <name>A0A1Y2ARZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BCR39DRAFT_311045</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARZ7"/>
    <dbReference type="FunCoup" id="A0A1Y2ARZ7">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARZ7"/>
    <dbReference type="InParanoid" id="A0A1Y2ARZ7"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORY24977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="189" mass="21462" checksum="6B6C2777C930EAEF" modified="2017-08-30" version="1">MFILNWFWDVLAQLGLMNKSAKLLFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELSIGNVKFTTYDLGGHMQARRLWRDYFPEVDGIVFLVDSADTERFAESKAELDSLLSIESLAMVPFLVLGNKIDAMGAVSEEEMRHQLGLYQTTGKGKIPLRDIRPIEVFMCSVVMRQGYGEGFRWLSQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASA5</accession>
    <name>A0A1Y2ASA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inositol phospholipid synthesis and fat-storage-inducing TM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_287389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000057">
        <property type="protein sequence ID" value="ORY25448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASA5"/>
    <dbReference type="FunCoup" id="A0A1Y2ASA5">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASA5"/>
    <dbReference type="InParanoid" id="A0A1Y2ASA5"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="458" mass="50295" checksum="1B012E7F777E672B" modified="2017-08-30" version="1">MSASTAEIPRIVTTTPTRARRERASFASPTDIKPQTPTARRMSMSSTSQSAAVVPSSIIEGILARPQAVLAGVITLTVLSGIVYSLIHSTSLDTSIASHISSPERSAYFARKSNIVNQWFIKLCWFWTSLIYLVHLFTSPSSRSQSSSGTATKTTSRIERRFSRFAAFLLATAIWYGFTSWFFGAGLGDRVIALSGGACAVPLPESWELDLEELAKLFPGQLPIIAKEKQGQQLYLPLPHSFCHTATALTPKSHPDLFSLLSAASSSWPAGKAANTLHPTEAHPDLVLPRPRWHRGFDISGHTFLLTMSALLLARELAPSWRAWVRQQQISIANQTSTTSAPTSHRRLSVHTVHRLVTLLGTALVALWLWMLLMTAIYFHNPPEKISGLILGLVAVWAINTLTPKSPFPTQPPSRRITPDQPGLADNENAARRGLVVNDGVLEEDDRQDDSPTKRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASC9</accession>
    <name>A0A1Y2ASC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_544492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASC9"/>
    <dbReference type="FunCoup" id="A0A1Y2ASC9">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ASC9"/>
    <dbReference type="InParanoid" id="A0A1Y2ASC9"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY25364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="179" mass="19327" checksum="477C0183F990AE62" modified="2017-08-30" version="1">MSDIEYLKSQLGVHPDFPKKGVTFLDIFPLLRNPLAFETLLTHLLHHILTTHRDSPPDVIVGLDARGFLFGPSLALRLGAAFVPVRKGGKLPGEVQVVKYEKEYGADVFEMQADAIKPGQKCIVVDDLIATGGSAAAAGELIKKSGGITLEYLFIVAIPFLGGEKKLDAPSYSLIQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATC6</accession>
    <name>A0A1Y2ATC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_542928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATC6"/>
    <dbReference type="FunCoup" id="A0A1Y2ATC6">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ATC6"/>
    <dbReference type="InParanoid" id="A0A1Y2ATC6"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="25"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="12">
        <location>
            <begin position="755"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="558"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY25823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="846" mass="92420" checksum="A20E5504A7C1E7F4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATD2</accession>
    <name>A0A1Y2ATD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_498814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATD2"/>
    <dbReference type="InParanoid" id="A0A1Y2ATD2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF78">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY25829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="512" mass="56475" checksum="6873AD2782526CDF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ATD7</accession>
    <name>A0A1Y2ATD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_590124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ATD7"/>
    <dbReference type="STRING" id="71784.A0A1Y2ATD7"/>
    <dbReference type="InParanoid" id="A0A1Y2ATD7"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY25560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="264" mass="29067" checksum="A071754E5C96F742" modified="2017-08-30" version="1">MAPTQFLHRPDGDIAYDDTLGQGRVVVCVPGMGDLRQSNRILVPLLRDTGYRVITVDLRGHGESSTAFTDFRASAVGGDLVALIDHLDIRNAIVLGNSMAAGSAVWAAAQRPERVAALLLTGPVIRDIPINPIVRTMLNIALWRPWGAVLWEKFYKMLYKSNPPADLDTYAKTLSRNLREHGRLEALQAMMRASKADCEARIGEVRANTLVLMGNLDPDFTDPAQEAQHVAKVLKGRVQMVEGAGHYPHIEYPALVVRALQEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUK8</accession>
    <name>A0A1Y2AUK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_261092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUK8"/>
    <dbReference type="FunCoup" id="A0A1Y2AUK8">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUK8"/>
    <dbReference type="InParanoid" id="A0A1Y2AUK8"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY26239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="371" mass="41310" checksum="A623BB785C376239" modified="2017-08-30" version="1">MLYVIGLGLSDEKDITVKGLEAVRGSTRVYLESYTSILMVPKERLEAFYGRQVITATRELVELSSDEILDGAKEVDIAFLVVGDPLGATTHTDLILRATQLSIPIQVIHNASILTALGSTGLQMYNFGQTLSLPFYTETWTPHSWYDRLMENLQVGMHTLVLVDIKVREQSEENMARGRLIYEPPRFMSPYTAFKQILYTESQRHPPRPLISTDSNPTSPRTSATPTTPTTPTTPTDPLNRTNSTTTTTTTTTTTTTTTTAPEEEEEEEEEEQGNIFERKARLSMLPPDKTLALSLSRIGTPTQRIISGTLTELASLSEDEFGPPLHSIVIVGKRLHPLELEYAGRFCVGGQNGDWWKVGKEVYGVERESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUV7</accession>
    <name>A0A1Y2AUV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="8" type="ORF">BCR39DRAFT_541344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000048">
        <property type="protein sequence ID" value="ORY26332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUV7"/>
    <dbReference type="FunCoup" id="A0A1Y2AUV7">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AUV7"/>
    <dbReference type="InParanoid" id="A0A1Y2AUV7"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="135" mass="15272" checksum="58C84EFB958B2766" modified="2017-08-30" version="1">MSVVATEMPSTSGLGYSHSNAPEQVASSIRQDDQLEIRIEFGGGLHLLFSQKPKYTIHIPRTIPSTSQHTNVKYLIQWMKENILSEREEMFIDGDTVRPGILVLINDADWELEGELDYELQNRDEVVFISTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVF4</accession>
    <name>A0A1Y2AVF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="8">HIU hydrolase</shortName>
            <shortName evidence="8">HIUHase</shortName>
            <ecNumber evidence="8">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_470543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="8"/>
    <dbReference type="EMBL" id="MCFC01000049">
        <property type="protein sequence ID" value="ORY26270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVF4"/>
    <dbReference type="FunCoup" id="A0A1Y2AVF4">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVF4"/>
    <dbReference type="InParanoid" id="A0A1Y2AVF4"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="114" mass="12385" checksum="65D6F495FA46EB32" modified="2017-08-30" version="1">MVKSPITCHVLDSSSGKPAQGVQVTLDLLDGPSDQTGSSTTDVDGRVSNLLHPSATLEAGIYKMTFHTGPYFEALATQTFYPFVEITFALSDPTQHYHIPLLISPFSYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVU5</accession>
    <name>A0A1Y2AVU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_540762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVU5"/>
    <dbReference type="InParanoid" id="A0A1Y2AVU5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="85" mass="9888" checksum="0FB252F037D19A96" modified="2017-08-30" version="1">MCIYQIQNIQPTRFPKRPYALVKWIFGLAVTNYFHFPKMFGPRERHDGDAIWLGLAPGRVAFTALRHCIGWGEGNLSQQKKRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVV3</accession>
    <name>A0A1Y2AVV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_484339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVV3"/>
    <dbReference type="FunCoup" id="A0A1Y2AVV3">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVV3"/>
    <dbReference type="InParanoid" id="A0A1Y2AVV3"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="457"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="807"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY26723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="949" mass="107746" checksum="C9569DAF45D1C269" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW22</accession>
    <name>A0A1Y2AW22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CND01770-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_594670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW22"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW22"/>
    <dbReference type="InParanoid" id="A0A1Y2AW22"/>
    <dbReference type="OrthoDB" id="2566743at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13957" checksum="2FDDFEE11B4E95AE" modified="2017-08-30" version="1">MYIPNLQGLLTAGLALTGALTKPSKVVKGHVLDYAVESCLDDDGNVRCSKPFLVKKSTCYKLSWSTDGTLSHTTAEVRDAGSDEIVYYRDTDGEWTPEKGELVYIDFKPKIAGQGNKTVDYKVDTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW52</accession>
    <name>A0A1Y2AW52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tim17/Tim22/Tim23/Pmp24 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_560679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW52"/>
    <dbReference type="STRING" id="71784.A0A1Y2AW52"/>
    <dbReference type="InParanoid" id="A0A1Y2AW52"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="223" mass="25166" checksum="FA9AD7610A3856F4" modified="2017-08-30" version="1">MSALQRYILDPANHDLLALVKGARNGLVYGVKVRFPHALVMTFLFSHKPLPAKIKWIFTATRAHALNLAKFVTIYKLFLLLQKRLNGGKERDLDSLIAGGLGGWWVFGERTPINEQIVLYVLSRTLLSLLPRLYSTTSNPPTNPIAPLPHPLPALTSPQANPKPIPPAQTPFAIVAALSWAGVMYMFRHRGERLQPGMNNSMRYLYHDSDAWNDIRTLLWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWM0</accession>
    <name>A0A1Y2AWM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_539706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWM0"/>
    <dbReference type="InParanoid" id="A0A1Y2AWM0"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="772" mass="86387" checksum="F9692802F6BC44A8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWR3</accession>
    <name>A0A1Y2AWR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_578327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWR3"/>
    <dbReference type="FunCoup" id="A0A1Y2AWR3">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AWR3"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY26999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32614" checksum="83177967B1BBC517" modified="2017-08-30" version="1">MGPALSGELSTFSTGSRTYPYFTSGDLQSHQAVVFIGGLYCGFLDPAYLIKLSEALGHIGWKLVQMHWSGAYDGFGTGSLDRDRQEMSDLVTHLRANGLEKIIIMGHSTGSQDVIHYLSSSDPVALVEGGIMQAPASDREFFTSETGDTQGWKEQLRIAEELIKEGKGDEIVDKAFCKAIGARMTAYRVHSLVGIGQVMTAPGDDDYFSSDLPWEDDGEHAHPLSASFGKLSAPALVLYSEKDEYGRLPDKTATLKSWEKAANGKLTAKIIEGADHAVTGELERENLCTEVVGWLKSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWT6</accession>
    <name>A0A1Y2AWT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_539076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWT6"/>
    <dbReference type="STRING" id="71784.A0A1Y2AWT6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWT6"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="342" mass="37731" checksum="410B0967C20B79C4" modified="2017-08-30" version="1">MIRLLITGASGYIGGEILAQMSDDPHKYGTIEVFAVYRKEEHGEAIRKMGSTPVKLDLSDGDAIKSFILEKQIDVVLELTDPVGSKIAIPSIEALSTLGGERTFIYTSGGKLFSAFADFDTLKETKDDDEDVINTLRNSNSEWIGAKIAKESYPLILETGKKLHVHTHIVVPPMVYGKSRTFGNQLSKQIVELVKIAKTTGKLWTIPQTQPSLGSLAQIWALCHIHDCASGYLALLDSILANKYAPDGIYFEENGKFAWEELSKGILRGLGLEEKMDVAGQEEMVRIADILGTEVEGVAVQMSGRANLKGNRLKSIGWHPKYDVEHLYSTMEDEARFIASQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX40</accession>
    <name>A0A1Y2AX40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX40"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX40"/>
    <dbReference type="InParanoid" id="A0A1Y2AX40"/>
    <dbReference type="OrthoDB" id="509690at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012033636" evidence="1">
        <location>
            <begin position="21"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="481" mass="50522" checksum="7C5FF290517371F4" modified="2017-08-30" version="1">MLYLIVCTILLAVMCQSVSSASVDYTSQVSAQGDRLPDFSFCGYHSSNDALPSIFSVVTTTLSPGSGDQAPRIQKALNNIASAGGGVLLLTAGNYTVDTSLIIPSGVVLRGAGTTKTILLPQSGASTFITMGMAAAPPIITPATNITDTYVGVGAKTFRVVSSSKLSVGQTVMVQRAVTDAWVRQNGMADLVRSGVAQTWLAVGTLVQQPRKIMNISGSQITIDVPLTDSLNSKYMHSQVATYTFPSGSSEMGVEDLGITLLPSCTGAAISDDTCNGNAINISAYTTDSWVRSVNITGFNQFINSSPGAMRITIDSVSMYRDKATNSSSGYPADITIQGTQMLVTGCGTFATSEATTFPIVVQNLTAGPNAVLDYYSQQSSFVISPHQRWAHGLLVEGSRSSISFGNRGTYGTGQGWTLNAGVAWNSNGSDIDIYSPPLGTNWCFGCRWIRSAGNGTFVDPSSTVQPQSLFQAQLAARGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXS5</accession>
    <name>A0A1Y2AXS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_599449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXS5"/>
    <dbReference type="FunCoup" id="A0A1Y2AXS5">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXS5"/>
    <dbReference type="InParanoid" id="A0A1Y2AXS5"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="685"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="741" mass="81546" checksum="91CFC5C09F5A4A7C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY00</accession>
    <name>A0A1Y2AY00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_539242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY00"/>
    <dbReference type="InParanoid" id="A0A1Y2AY00"/>
    <dbReference type="OrthoDB" id="2563819at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY27097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="314" mass="35370" checksum="E6885D90F5323062" modified="2017-08-30" version="1">MPVTATPSKRQRRSERSHVSRACDPCRGRKAKCSGDKPACQTCLRSGRTCVYASDADGRSTERTARQQVELLQSRLQEFESGMSGLDDSAETRDTRANWQPFPTGRLVLSANGNLHLLPSATFYHPAHAAPAWQQILEALEPRPVPLPGYLAPYLPFPMAQDHHRQILHNAFDNLLSFGMNSFEGVFLETMEADSNSRGLYFSPMLHLCCLGVGWRYCRDRRLFAMYHDQDTPYENRGDAFIQKAADLLLDDMAAPRLSTLLSLMLLTLYHIGMLKESLATSFTGENQVPAVLILYSDGNLHRYRLQVFCVSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYC6</accession>
    <name>A0A1Y2AYC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_538239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYC6"/>
    <dbReference type="InParanoid" id="A0A1Y2AYC6"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="27"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY27486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="504" mass="55396" checksum="549ED9432C237AF9" modified="2017-08-30" version="1">MDSNDIIEAEKLRAEEKRVVRKVDWLLMPILTITLGLQYYDKAVLGNAAVFGIIKDLDLSTTVNGVTSTKRYSTATAAFYWGYIVAVLPFAVLLARLPLAKTAAVLVLVWGVICILTTVCSNYSGFIAQRFFLGLAESAVSPAFVAVTALWYKPYEQATRMGIWYSATGIFSMISGLINYGIGHNHLAHKWKGMYYFCGSVTIAWSFVIWFFLPGSPLQPGRFFNEREREVLRRRLEENPFGKDRMPLKFDQFIEAVMDIKTYIYFLMGTAIYICNGSVTAFGARIISGFGYDSLTTTALLIPGGAVTVLTIAIFSTIADKYKDSRTYVLPVSCIPVVVGALVIWLAPWHPTAGPLIGYYLVASFGAPYVLLLTIAAGNVTGATKKAVTSGAIFIGYNVGNIASAYLVFTQEKAVKYRSTWISVIVGMVVASALSLLLRFIFIRENARRDALAAHGSTSTSAGHAEGAEKSALGSSDTHLPHVEKLEAYEDKTDKQRSEFRYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYK7</accession>
    <name>A0A1Y2AYK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_559941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYK7"/>
    <dbReference type="InParanoid" id="A0A1Y2AYK7"/>
    <dbReference type="OrthoDB" id="2224399at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY27661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="239" mass="26050" checksum="2163D81E9EA4CCD0" modified="2017-08-30" version="1">MTANIDPFNAALCCENFHQPASSSTLPTFVAHFAPSSASSIPVAKVQEYSDGTFHNYYPLGISLFFSPSSEDKQQRLLDRIDIYNPPSNSPPLARRRGGANTPWAGYSPPRFPIVFTFNSTSLTIPPSKPDEPPRIIPRPGELLVDGRTKAKDFVAHFGEPTKKGGKLGWVPLFLEWASVGLKAPDGSAVKLGVMLELNDPGPEGMQALSDEVKKKGVGGIWDQAAEWEWADLKLFPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYL4</accession>
    <name>A0A1Y2AYL4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_537855</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AYL4"/>
    <dbReference type="InParanoid" id="A0A1Y2AYL4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000061">
        <property type="entry name" value="ATP-binding cassette transporter YOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1028"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="241"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="603"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="908"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1223"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY27673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1484" mass="165268" checksum="103D91A0161B8155" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYM7</accession>
    <name>A0A1Y2AYM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_539585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYM7"/>
    <dbReference type="STRING" id="71784.A0A1Y2AYM7"/>
    <dbReference type="InParanoid" id="A0A1Y2AYM7"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="689" mass="75702" checksum="FAEB2DEF8DC38139" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZN9</accession>
    <name>A0A1Y2AZN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_536423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZN9"/>
    <dbReference type="FunCoup" id="A0A1Y2AZN9">
        <property type="interactions" value="924"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AZN9"/>
    <dbReference type="InParanoid" id="A0A1Y2AZN9"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY28048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="328" mass="36041" checksum="8723D9E22444F9B2" modified="2017-08-30" version="1">MMSTFGRTNVKPDVELVQPPSDSVSTILFSPTQDILATGDWASEVRLYDVNSQGQSQPRAMYKHNAPVLALAWSKSGTVLFSASCDKTVQMFDINNAAQGSSQVAEHAAPISCCLTITAGNGLEYLVTAGWDKKLKYWDLSTRTLWGEVDLGERAYTMDATDKFLVVGTADRKIHLIELTSPNIIRKTIDSPLKWQTRVIRCFPTQDAYAIGSIEGRVAIQYPYMESKNYSFKCHRLDIPTGTMPGTPATASSQHVFAVNTIAFHKTLGTFCTGGTDGTITFWDGVARTKLKAYSAKELNNGNHEARPPEFGIPIVSATFNHNQEIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B022</accession>
    <name>A0A1Y2B022_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_468625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Preautophagosomal structure membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B022"/>
    <dbReference type="FunCoup" id="A0A1Y2B022">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B022"/>
    <dbReference type="InParanoid" id="A0A1Y2B022"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000150">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="130" mass="14064" checksum="0C425291D366FBDD" modified="2017-08-30" version="1">MSAAAPIPDLLSPPLQKPQLVTSQLLKPSAREALEQYKVKDASKVVVRFKSIGSAPIMKTNVFKVTAGNKFQAVIVFLRSQLGLKPGDPLFTYINAAFAPAPDDTVGNLYKCFGTEGHLIVNYSNTQAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0W4</accession>
    <name>A0A1Y2B0W4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_534729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0W4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0W4"/>
    <dbReference type="InParanoid" id="A0A1Y2B0W4"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="473" mass="51443" checksum="1899DBB2DC86D131" modified="2017-08-30" version="1">MPDSNNNSYVVISGGTGANSFVSAFGSSPAFVLPVSDDGGSSAEILRCFGGPSIGDIRSRLIRLIPVVQDADSIEDKEIEAIYNLMAFRFPADVPDKLSKDIWEEIVEGRGSLWQDIGEDKRECIRAFLVHFQTLCLRRAHKRFSFRNFSLGNGFLTGARELFGSLPSAIFLFKSIAGLNAGVQVIPVINTNHTITIAAKLANDHTLVGQCNISHPIPAAETLNGTSDTLLRQPHPVSQAALLLHSRRRDSRTFDTTSFLSSVDTSSFDEIRGSLDTPVETASDGNLGYRKGEHEEPLEAPIERIFYINPYGQEIFPDPNPSFLAALSSRSTLVYSCGSLYTSIVPTLALRGVATAIATSSTLRAKVLFLNVVNDRETPGYTAIEYVDAVVSTLRRSDRPHKHGTSRGNGSAWPDSKLVSHLVYLEEGAVEVDPAAIEALGVKIVMVPKNIYGDTTLFSQQAVQWAMAQILPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1J7</accession>
    <name>A0A1Y2B1J7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sec63 Brl domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_534396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1J7"/>
    <dbReference type="FunCoup" id="A0A1Y2B1J7">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B1J7"/>
    <dbReference type="InParanoid" id="A0A1Y2B1J7"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="650"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY28616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="727" mass="81561" checksum="EBD5BBC589370304" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1V9</accession>
    <name>A0A1Y2B1V9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_534124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1V9"/>
    <dbReference type="InParanoid" id="A0A1Y2B1V9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="90" mass="9940" checksum="350F3C6C90687FFF" modified="2017-08-30" version="1">MFRSVRIPPCINNPLSFHSFHSLPLPSTPFTPFTPFHSVQSFRPLTATRLPRPPPGDPDVLPPCPTVCLLLIFSFSQDRTLPLDLTAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1Y6</accession>
    <name>A0A1Y2B1Y6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_559395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1Y6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B1Y6"/>
    <dbReference type="InParanoid" id="A0A1Y2B1Y6"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="8">
        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="87"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="346" mass="38031" checksum="BB90DA3E3F5D52C9" modified="2017-08-30" version="1">MAQPLFHQPASVYATDWHDDELDTEAVDQSLPSTPMAEKYEPYVHRSAAEMPSEAPELESDVSPSPEVDVSSEDHREVKPEQDEPQCRICFGGVEEEEMLGRLISPCLCSGSMRYVHVQCINAWRGTGTNAKAFMECPQCHHHYRLRRTLISGIATSRPLLLLLSSTFFLLLTLSSGALIHYLLLSPRLSSSILSPDVRLSTGNLFDLDMDDDYMYDGGGIVIIGGGTTLVADVVFGAIQAFTLIASRLSELDLGMPLPPFLSSIVYWLGLRVLLGISLLGSLSFISLLLSFSLFAPLQIANNFRGGFFRRFRTAQRTEGGGTSVGTIMIVLFVLVGAVNSMRRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2Z9</accession>
    <name>A0A1Y2B2Z9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_588408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2Z9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2Z9"/>
    <dbReference type="InParanoid" id="A0A1Y2B2Z9"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011988181" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="352"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="618" mass="65221" checksum="3BFCABE549664A57" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B452</accession>
    <name>A0A1Y2B452_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1680-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_559136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B452"/>
    <dbReference type="STRING" id="71784.A0A1Y2B452"/>
    <dbReference type="InParanoid" id="A0A1Y2B452"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049049">
        <property type="entry name" value="Beta-AFase-like_GH127_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20737">
        <property type="entry name" value="Glyco_hydro127C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="2">
        <location>
            <begin position="60"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 C-terminal" evidence="3">
        <location>
            <begin position="583"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY29330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="79230" checksum="FD0EED4FAE15EFD0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4Y9</accession>
    <name>A0A1Y2B4Y9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_532084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4Y9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4Y9"/>
    <dbReference type="InParanoid" id="A0A1Y2B4Y9"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="270"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="476"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="588" mass="67287" checksum="BEE3BB68D28C3E6B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B582</accession>
    <name>A0A1Y2B582_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_530467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B582"/>
    <dbReference type="InParanoid" id="A0A1Y2B582"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="231" mass="25407" checksum="7D283DCDF3D94802" modified="2017-08-30" version="1">MLNSPHQNFVSRPSTCSISPHQSPVSDWPPDTWEQEGSVRIRKEPPHISARQLPYRLTPTTSFATQSARPLPVPVPRHSSYSGTTALQRSVSHMAAVLEQRTAQERHDISRVHHSHKVFVRGCELCTSRKPVRPIMNHQGQKRSVTMPPMYTSIPSSPVTSTSRANQDQAKTGHGTGREESGVSLSSPAVNGGQESRRSSYYVPSSALRTGAVVLGPRVRGGRHIRRGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5A4</accession>
    <name>A0A1Y2B5A4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_530582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5A4"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5A4"/>
    <dbReference type="InParanoid" id="A0A1Y2B5A4"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="178"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY30009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="333" mass="36847" checksum="E46EC42065F5544B" modified="2017-08-30" version="1">MSLRYTMGLSQTLLRSGCKCRSPPTILNHLNVKSIHTSSPSMGFRTQKTPPIFFSSHQSTAPPRSMLRLLRSSFRPFSTSPRSLVRPNYFPKNQRGSGSSGSGGGGGWQSFRLAWKRMRYRIDALPENFIIYGLIGTNVAVFLIWQYAQTSFQRFKDPSLYYFMARNFLFSEANLYAGRVWTLITSSFSHIGAEHIFMNCLGLYFIAPITLQITGGSAFLGLYLVGGALSSIAGLAWSKFSGRRDVWSSGASGAVYTCLAFFAALAPQAKIYLWFIVPMPAWLLVGGIFAWDGYSALTHPNSTTNSAAHIGGLVTGILAALRLRRMGFRGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5C6</accession>
    <name>A0A1Y2B5C6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_530729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY30029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5C6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5C6"/>
    <dbReference type="InParanoid" id="A0A1Y2B5C6"/>
    <dbReference type="OrthoDB" id="9995831at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="542" mass="59091" checksum="DB768D9D135A66A2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6A2</accession>
    <name>A0A1Y2B6A2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_150219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6A2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6A2"/>
    <dbReference type="InParanoid" id="A0A1Y2B6A2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="260" mass="27227" checksum="24B2CA64B74CDB5B" modified="2017-08-30" version="1">MASGQSAPPPQTQSVFAPGETVHDLLHSILGVNPFSSAPAVQTPTFDSRSPSQQASEPTRQVSVPPTQSPAPPNQVRAYSNSPAIPPGPYPPYSPGSASKIPTSLAAPVSPPAKASTPWTKIGDASFAQAAGGGSGGAPSDTDAVPGTDADLDFVLQAQTSNYSGRNGGQINQQRRRSPPKKTGQFNGHFDERAAKADTLVNGMVSRPKQFGKVPMSMINDTAKKLQFKQSLLELIHSDPAFVDELWVGYLTRRAQAGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6Y6</accession>
    <name>A0A1Y2B6Y6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_529157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6Y6"/>
    <dbReference type="FunCoup" id="A0A1Y2B6Y6">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B6Y6"/>
    <dbReference type="InParanoid" id="A0A1Y2B6Y6"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY30609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="221" mass="25302" checksum="E7859264BB412206" modified="2017-08-30" version="1">MAQPVEQWFTDIPPVTRAWVVAAVGTSLLVECQVVAPVQLWFSWKAAIGNMQVWRIFTTFFYFGPLSLDLAFHLFFIMRYSRLLEENSFSNKRADYVWLLFLCSCFLLCISPLLTLPFLSSSLAFALVYIWSRRNPSIKMSLFGVITITAPYLPICLVGFSWLLQGGYRAAIGDIVGMLAGHTYVFLQDYWPREMWSRTGKGEIQTPRIVKRIFGQQIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7Q8</accession>
    <name>A0A1Y2B7Q8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_528198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000018">
        <property type="protein sequence ID" value="ORY30764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7Q8"/>
    <dbReference type="FunCoup" id="A0A1Y2B7Q8">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B7Q8"/>
    <dbReference type="InParanoid" id="A0A1Y2B7Q8"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY30764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="307" mass="34432" checksum="CC553D8C26249869" modified="2017-08-30" version="1">MQHSSSSSSSPLHAATLIADYILTRHQQSHMTASNDGSGISKVTQLRPLMVSMQGPQGAGKSTIAYLLVNILKQHKLTCVVASLDDFYLTHVELEDLAHRNPVNGLLHGRGQPGTHDVDLLIAVLEKVQQGEAFQLPVFDKSLFQGEGDRCQDGILVIPPVDVFILEGWSIGFQPVNPDDLDATYRAATHQAAHQRPLFLNHSLESLQAINDNLREFASRVYPFFEIHVILQAQSREYVYTWRLQQEHTMKTKNGGHGMLDGEVKLFVDRYMPSYELFEEGILEHWSQRAFIVSLGEDRSVLGHRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B897</accession>
    <name>A0A1Y2B897_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_528069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B897"/>
    <dbReference type="InParanoid" id="A0A1Y2B897"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="64"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="550" mass="60765" checksum="0176C4E57CABB096" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8C0</accession>
    <name>A0A1Y2B8C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_460198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000017">
        <property type="protein sequence ID" value="ORY31069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8C0"/>
    <dbReference type="InParanoid" id="A0A1Y2B8C0"/>
    <dbReference type="OrthoDB" id="3366231at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="86" mass="9409" checksum="CECE142A956BA8F3" modified="2017-08-30" version="1" fragment="single">MEELGLPNASRSFAGQTGRQLLDDERQFDHDALRREYDLGWAQANGDQQTAISTVTRALGNNHGGLFFLDGPGGTGKTFVERLMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA01</accession>
    <name>A0A1Y2BA01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lincomycin-condensing protein lmbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_87359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA01"/>
    <dbReference type="STRING" id="71784.A0A1Y2BA01"/>
    <dbReference type="InParanoid" id="A0A1Y2BA01"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="585" mass="62391" checksum="E847201B359CD9CA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA95</accession>
    <name>A0A1Y2BA95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_525345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA95"/>
    <dbReference type="FunCoup" id="A0A1Y2BA95">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BA95"/>
    <dbReference type="InParanoid" id="A0A1Y2BA95"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="13">
        <location>
            <begin position="261"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY31781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="361" mass="38897" checksum="4023D7D8CF7FCC54" modified="2017-08-30" version="1">MSRSYKIHVPATTANVGPGFDVCGIALSLSLTLAVTIPAQPSASSSTPILPVITYAGLDSSNVPLDPYQNLLTRVALYVLRSHDIHSFPSGVTIHAHNQIPFGRGLGSSGAAVIAGVLLGDLLGNLKLPRSRLLDFALMVERHPDNVTAALVGGFVGSYLKELSPEDTSAASIPLAEVLPEYPPDAGPQWGMDPPRAPRDIGHYVKFGWAKEIKAIAVMPRFELATAKARGVLPETYSRKDMVFNLQRLAVLTTALARSPPDPDLIYEAMKDRIHQPYRMALIPGLPEILSTLTYTSHPGLLGICLSGAGPTILALATHNFDAIAAEIQRIFKKEGVEVDWEVLEVDERGSWVEEITNETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAB6</accession>
    <name>A0A1Y2BAB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="10" type="ORF">BCR39DRAFT_525350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAB6"/>
    <dbReference type="FunCoup" id="A0A1Y2BAB6">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAB6"/>
    <dbReference type="InParanoid" id="A0A1Y2BAB6"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY31788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="484" mass="52244" checksum="BF3B29242F5AC759" modified="2017-08-30" version="1">MVAEINMEEPAAAAPRALQLPISLFTRHSDLTIPQSTYMIPSSWRRYQLSELINKVLSLPTPVPFDFLVEGEVLRGSLDAWVKRNRGGDEEGEVRVEYVRSMMPPEESGRIQQEDWVSGLSLARPGYILVSSYLSHLRILPLASTSSAEETNTGLYTLPLPNLLGATCCTYLSPQSVTSDIRIAAGGVDRSVHVFQIPSLDADVASSSSGRELYTLMGHTGPISSIAASSNGSELVSASWDGALNYYALPEEEPTEHTFPAEPTTFLPGQKKRRRLNGDAGKGAIEGLKDGDVGAEGWRRGPDGVMRGHKGRVGGIVWDKNNGDKVWSGGWDGSVRGWEVGSGANAVIRQGPSDKSILCIDQFRATGTLATGSMDRTICLWDTQQATSLISLTLPTSSPVAAIACHPTNGFTLASATYHGQIQIWDVRSPKSPLFTAQKQGVNREVTQNGKRLGERLLALDWDGEVIVAGGEDGEVGIWRARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAC7</accession>
    <name>A0A1Y2BAC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAC7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAC7"/>
    <dbReference type="InParanoid" id="A0A1Y2BAC7"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31688" checksum="2336C47218BAC64E" modified="2017-08-30" version="1">MTTTKSRFDPAAHLTKQGWKGKGTALKHGHITRPIAVVQKKSLSGIGKDRDEAAPFWDQIFASTAATLFTTPTESASPTPSGSPGPSAWATLSHLDAGRPQPTPKVRQRVELRVQINQESARRGLYSRFVRGVELKQEEPKWEQEVPGLESQVIDAGPSQYAELEGKNSERGKESKEEKRARKEERARRKAEREERRQRKAANTIAETESKQDTAKSPADNLDTEVQPSKDKSTLQGKVAKATHDDIEGGSEKVKRKRRKDEESGLDTKKKKKKGREGDKMSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAE0</accession>
    <name>A0A1Y2BAE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_526742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BAE0">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAE0"/>
    <dbReference type="InParanoid" id="A0A1Y2BAE0"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="806"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="679"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="749"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1184"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1858" mass="206866" checksum="6724E0C60776634C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAP7</accession>
    <name>A0A1Y2BAP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAP7"/>
    <dbReference type="InParanoid" id="A0A1Y2BAP7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="150" mass="16583" checksum="9D64E84BC5823C15" modified="2017-08-30" version="1">MHSNHMLIKKSSMVHETSQQSPAQRFYTSSSARHSSSLVGRNVLLGHRGPSVGGALALAGSNQHVADRIRSLALTWSFPFLSDTALHITQSSHMRRRTLLMCCFHQMWRADRVSSSTESGGVQAADWISSVEGFFWLVAFTRVMGESSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAX7</accession>
    <name>A0A1Y2BAX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_524815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAX7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAX7"/>
    <dbReference type="InParanoid" id="A0A1Y2BAX7"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000025">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="320"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="487" mass="51219" checksum="E9068749FA862393" modified="2017-08-30" version="1">MPGSKRRALKNLLSPESKPTSSPPPLNDSPSSIAIPTLSSSPISGSSPTDQSTISLPSSIGGGGGGGSGSGDKEKKHSHHFHLPHFNGHGHGSRHGNGNGRRSSIEQANLGSVMSINSDPGIGEYQSDENQIRRNQTIDQALIVDEMQQREHSIGSHGQRIQDGIAGLSVSPSPISTSTSPAPPTPSSPKQIKAHMQQAGAAQTAAAQGGMYGAKPATGPAAGGGGRNGGGGGLYAPAGAVPVTANELLGNGAGSGNGNGTGGRGKKKSSRQKFEERQARKREALLHSAPPSDPGWTAQLEKERQDEIRIISDACAVLGREIYEIAPDGHCMFNAIADQLYQVGMIPAHQATNPLHLRRTAAQYMLAHPDDFMPFLPSINGEDAAGATDDGLITEKEFKSYCRNVEETGEWGGEPEIQALSRHYNIPIHVIQRGPPTIVSHGGNNDTFGGVLTPEQSASQGDRVVRISYHKRMYGLGEHYNSLRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB98</accession>
    <name>A0A1Y2BB98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_526319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB98"/>
    <dbReference type="FunCoup" id="A0A1Y2BB98">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB98"/>
    <dbReference type="InParanoid" id="A0A1Y2BB98"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY31365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="151" mass="17072" checksum="743D22755BC9C8C3" modified="2017-08-30" version="1">MSNVSTRRIQKELAELANEPLKNIEIVPNENNMQHWTVTITGPSGTPYKGGKFIMTVEFTLEFPFKPPAIKFKTKMYHPNIDSDGNLCLGILKTDQWKPSTKMNTVILSIYDLIQTPNPDDPLVTSIADLYRTDRAAFDKKAAEYTAKHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBJ3</accession>
    <name>A0A1Y2BBJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_524226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBJ3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBJ3"/>
    <dbReference type="InParanoid" id="A0A1Y2BBJ3"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33054" checksum="EA582AF4FB317062" modified="2017-08-30" version="1">MSWFSDKMARLTPFFVRGKRYIGRDLEGNKFYELPSKTDARPKRVVEYRRMSEMSDYTSGKHRLPVQWSTWLSHTRSDPPTLSELETDASRLQSLQPLVAAIAERERAERIRQGYLIEPDDASSSKPPRLPPSRETVQRTIKVLEPSFAPPPPSIPPSLSIPSPSPSPSPFSPQFSSSSPPPPSPFPQSRSSQTDESAQPTPSSRLGPVRESEQQSYPIPTPSRPDLAPPGKPVDPSAYSSREELRRLSEEDTKRRMAQSGVDTQSAASDPAQVGNAKEPGSSPSTSSGLQPRRRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBN3</accession>
    <name>A0A1Y2BBN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Family A G protein-coupled receptor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_43126</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBN3"/>
    <dbReference type="FunCoup" id="A0A1Y2BBN3">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BBN3"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="243"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY32241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33622" checksum="3D0B31BECC073220" modified="2017-08-30" version="1">MLISDLVIMVWHFTIPRGQRVFHQIAVILLTTAAIAYFCMASDLGFANIATEFSYLGFPRGTYRQIWYVRYIDWTVTTPMLLLELVLASGLPLSDVVTLIFFDLVMIITGLVGSLVESSYKWGFFTFGCAALFYVWYVLLVPGIASAGVLGSDYKRSFTTSTAILSFLWLLYPVAWGLADGASVISPDSEMIFYGILDVLAKPVFCFIHLYSLSKLDLTALQLSSGKFSASAVGAAGYDAEKTSRFGRNPRNSGSTLAAANSTPETQTTPAKRGMFTSKGRYDARQNPVTVHPIDNAPRNGAATAVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCG5</accession>
    <name>A0A1Y2BCG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl hydrolase family 88 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_479381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCG5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCG5"/>
    <dbReference type="InParanoid" id="A0A1Y2BCG5"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="398" mass="44770" checksum="DF9FB686BF59219F" modified="2017-08-30" version="1">MPSAEKLTPERAEELIRLMTDGLVNIVDETGQFLLKLKDGTVIDTKGWKGWEWTHGIALTALCHHSSISPSSASAQHSLKTALDWFELQYKLSDGKGAPKNINTMSPFYSLACFLQDGRTKDPRWKDWCDEWAEWIMKDLPRTEERGFQHMTYANLHENQMWDDTLMMSVIPLAKIGVLLDRPEYLQEAVYQFLLHVQYLADPVTGLWYHGWRFTPDGKPTEFSVTPNGPNFGHNYARALWARGNCWITVSIPILFEIMGDRLESGVREFLISVFKRQVDALVTLQDEETGLWHTLLVDPTSYVETSAAAGFAAGIYAGLRMGLIKGDAYSKCADRALQGVLDHISPNGQVDQVSFGTGMGKNLQFYKDISITPMPYGQALAMAALVEWERLQGVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCR5</accession>
    <name>A0A1Y2BCR5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCR5"/>
    <dbReference type="InParanoid" id="A0A1Y2BCR5"/>
    <dbReference type="OrthoDB" id="10568483at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="338" mass="36646" checksum="223AA4EB71DB3A81" modified="2017-08-30" version="1">MRKGAPNPTTVPKGAFTSKKKTPGKSIRFKGLTLRSRSIRAGLEAPKLDIKGLMKTPIVIGQAPGSPLGSWDIAHAMSVQSQVSSPIRDHPAIHAQRTGSSAGQWPMPSQPLEPQMTGTGEESCVISKAGKDDIDMEIKPDLVKNLIKVFQLDTVDRVILDSTRTPANTPSRPKRGHPLAPPTDIDMSAFEGEGPPKFANYAPTVSMHGSISSSSTLRTLGTLGSRRGTVRKRTPLCQVFANPPEQAQAQEVVVDMYEARKAMTLLERLLPLAAHLIPLPADVDEDESYDVSGVDQEDLKEAREGLVRELEQKGLELVMLFEEEPLPLSAAQSPDLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCV9</accession>
    <name>A0A1Y2BCV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_522777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCV9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCV9"/>
    <dbReference type="InParanoid" id="A0A1Y2BCV9"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="150" mass="16440" checksum="93B4255CD52DCBB1" modified="2017-08-30" version="1">MSAGTSKKATIYVGNLSPEVHEQQLLDAFVTFGDILEVIIPTEPHEPSKHRGFAFVTFASPADAQDAIDNYDLNELPGTRGSGRFLKCSIAQPNKFGNEAAGEQRFDRPVWESEEWLQKYSKPDEPNGEQNGEPAVAAGQETSGQAEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDX5</accession>
    <name>A0A1Y2BDX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_523726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDX5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDX5"/>
    <dbReference type="InParanoid" id="A0A1Y2BDX5"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="320" mass="34928" checksum="071B38B994202907" modified="2017-08-30" version="1">MFEFLIALVLATLLMIVLMAVGVGLTMPFHGALVRLRANYNPRAVGLEGTENRVGPTLNTLVQTLKRTKRLEGWYGLYKGSYPMLIFFTLVSIASVIFVGGSSTRGPKGTYSTPPAGGIRMGIFTIILTLISLPMTIIINRAIITPYRLPINPRTSLSILLTPLELAAPWKLYLTPGLLATTATHSICVTFLARTVRVGVLGVSDPSDAEASIAAWRWIIFLIFQATATIWLTPLEIIGTRLSVQPNTGGLQAIPSEEEGLPEGVEYAGTNEDVIGLRPTTDPYEGMLDCARKLVDEEGWQSLYRGWWWTMGSNIFGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE91</accession>
    <name>A0A1Y2BE91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_521440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE91"/>
    <dbReference type="STRING" id="71784.A0A1Y2BE91"/>
    <dbReference type="InParanoid" id="A0A1Y2BE91"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="264" mass="28344" checksum="C936545262F11541" modified="2017-08-30" version="1">MPGRSPLGAASSLRPLFARSLQTSAPLSPPTQILSSSTFPAAPSSSTSSNSALASSSSSSEPITSPLLSHLPPILPSTTPAPSLPQTTTSALSLLKSQSTSTAGIYILARLHSRTYLLHPRDILSLPTLKPRQPPGSTLALTRILEVGSRDFAVRAPAANASQLRKQLEWWDLQALPTLDQSVVSCELTVLEHTRSPRQDTFKKKRRKGYEKTIRAKHAWTRLRVGDIILGDGEGVKAGEWTGPTTWKDTNHTADTVIGKASET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF58</accession>
    <name>A0A1Y2BF58_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_302890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF58"/>
    <dbReference type="InParanoid" id="A0A1Y2BF58"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="516" mass="59166" checksum="2CB9AB6D5C409462" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF66</accession>
    <name>A0A1Y2BF66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_563976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF66"/>
    <dbReference type="FunCoup" id="A0A1Y2BF66">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BF66"/>
    <dbReference type="InParanoid" id="A0A1Y2BF66"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="140"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY33473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="525" mass="60129" checksum="EB3409D225107F17" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFF3</accession>
    <name>A0A1Y2BFF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_557131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFF3"/>
    <dbReference type="FunCoup" id="A0A1Y2BFF3">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BFF3"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="12"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="274" mass="29665" checksum="26F11E0D822AF17E" modified="2017-08-30" version="1">MTVPATVKKGDAYFLSHGGPNSISEPKTGAYKGWKDFGRIVTEAQPKGLVIVSAHWENVGREGVLVNSDSSNPLIYDFYGFPKHFYELKFESHGDPVLLKAVVSALEKAGIPVATEKRGLDHGVWGPFLAAFDGKTDIPIIQVSLPGDSSPVTTAKLGKALAPLRDEGYAVVGSGQVVHNLRDVFGRGGDTSGYAPQYMQASIDAAASSKPLEAAMTLFRHPLYKRAHPTPEHLLPLLISTAAVDEGDELETIYAEYSKDNLGWADWRWKSQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG11</accession>
    <name>A0A1Y2BG11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nuclear actin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_519097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG11"/>
    <dbReference type="FunCoup" id="A0A1Y2BG11">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BG11"/>
    <dbReference type="InParanoid" id="A0A1Y2BG11"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="759" mass="82862" checksum="83F93D80149255AE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG42</accession>
    <name>A0A1Y2BG42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_557011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG42"/>
    <dbReference type="STRING" id="71784.A0A1Y2BG42"/>
    <dbReference type="InParanoid" id="A0A1Y2BG42"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="5"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="83"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY33784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="600" mass="66393" checksum="65A1B6022FD35A87" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGQ1</accession>
    <name>A0A1Y2BGQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_518005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGQ1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGQ1"/>
    <dbReference type="InParanoid" id="A0A1Y2BGQ1"/>
    <dbReference type="OrthoDB" id="9975758at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY33978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="198" mass="21570" checksum="D5E5A012B9B29E7F" modified="2017-08-30" version="1">MSDTILIHPPGSSHPSLADGPTGFDRKWLMGKWGVTWSTLPMWKDKKDVVITYDPVAAETRIDTTFDSTVEYRKTSAAANSKPSTVRGSETLSTGANGATFDWRGKSYLFFVTSHWEILGYGKDDSNGLDWAVTFFSKTLFTPAGIDIYIRASPSATVPASTEARIALRDKLVSLLKNNEDQGVVKLADGGFEVPGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGX9</accession>
    <name>A0A1Y2BGX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative intracellular protein transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_491496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGX9"/>
    <dbReference type="FunCoup" id="A0A1Y2BGX9">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BGX9"/>
    <dbReference type="InParanoid" id="A0A1Y2BGX9"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="169"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY33737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="427" mass="48702" checksum="20D19036088ED1F4" modified="2017-08-30" version="1">MISAFFIFNQKGEVLISRLFRTDLKRSISDVFRIQVISNPDVRSPIITLGSTSFFHVKINNVYVVGVTKCNASAALVFEFLYRFITISRAYFGKLDEESVKNNFVLIYELLDEILDFGYPQNSEIDTLKMYITTESIKSEMAVREDSSKITIQATGATSWRRSDVKYRKNEAFVDVIETVNLLMSKEGAVLRADVDGQILMRAYLSGTPECKFGLNDKLVLQKRGDTGPKSEDAVELDDCQFHQCVRLGKFDTDRSISFIPPDGEFELMRYRSTSNINLPFRLQTHVTEPTKSRVEYTIHLRASFDAKLNANNVVVRIPTPLNTTKVESKTGAGKAKYHPGENFIIWKIPRIQGQQEYTLTAEADLAQTTHRQAWSRPPIELDFSVVMFTASGLLVRFLKVFEKSGYQSVKWVRYLSKANGSYQIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHW8</accession>
    <name>A0A1Y2BHW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50B-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_264768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHW8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BHW8"/>
    <dbReference type="InParanoid" id="A0A1Y2BHW8"/>
    <dbReference type="OrthoDB" id="2567489at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="161" mass="17824" checksum="78E1EAF7B2B528DE" modified="2017-08-30" version="1">MEPRASVEWAKGHLTDAQVESIKAFVGSAIVTLVLWNGFPPIGTRDVWSWDEDKDGEIKTNDKGQPMGQWKKKIRWLPVLYPFKILTVFYHEISHAIVGRLTGGKPTFVMVDPYEGGLTEFALPPHKQPEPKSTLAAGYIGSCVFGCALIFAGCEFLSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI79</accession>
    <name>A0A1Y2BI79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_519303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI79"/>
    <dbReference type="FunCoup" id="A0A1Y2BI79">
        <property type="interactions" value="771"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BI79"/>
    <dbReference type="InParanoid" id="A0A1Y2BI79"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="5">
        <location>
            <begin position="263"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="845"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="940"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY33805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116609" checksum="804B981A842F3BAB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BID5</accession>
    <name>A0A1Y2BID5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_517567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BID5"/>
    <dbReference type="InParanoid" id="A0A1Y2BID5"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="150" mass="16565" checksum="AFE7258B422D8F8F" modified="2017-08-30" version="1">MRSIRFAETIPLTSGILCFTLAWAGYTLVEIHGRNASVEVMLISTWVESTINTVLMVSWIMIRKDTMLAMQELKVPTAFPIAYIMTAATISLLEAQLVTAIASHVKTYGFHSLFSSSFWRDTTGCWSERAALGADTMVPGANEAVVEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIY2</accession>
    <name>A0A1Y2BIY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_513271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIY2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIY2"/>
    <dbReference type="InParanoid" id="A0A1Y2BIY2"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="774" mass="85833" checksum="2DF4863B9F764A1C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ95</accession>
    <name>A0A1Y2BJ95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_515084</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ95"/>
    <dbReference type="FunCoup" id="A0A1Y2BJ95">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ95"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ95"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="114"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY34839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="586" mass="62726" checksum="4348D4C106C03FFA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJG4</accession>
    <name>A0A1Y2BJG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-D-glucosamine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_477181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJG4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJG4"/>
    <dbReference type="InParanoid" id="A0A1Y2BJG4"/>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052519">
        <property type="entry name" value="Euk-type_GlcNAc_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190:SF3">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="49016" checksum="E09D4AADD23A57E9" modified="2017-08-30" version="1">MVVRPASPHVSPPSPISSASSSSPTSSSRRLPSLVLCADGGGSKVHVCIRTSDGLEVRGTAGPCNVSSVGHALAVQRLLLATYRALACLPPSHLPSTFQHPLLPSDSLSMSSSFHIPTPNKADVTPYASHTQTPQPSRPSSPSTSATMPSLNVPLFAAIWLGLAGLQTPANAAAFTPKVCKAFNAPLDRVRLTNDVILLAAPVLSRQEFNYVAAVVCGTGTVGRTIRLDRQESHGIGLEVVGYSRGWGHLLCDEGSAFFLGRAALRSILFALDRSNSSHLFATKPDPISTPTFSTPLPLHRDLLAYFATPDPADLIGLVSLSGPGVEGVEVGEAVGKRNALVAGAARVILRWAFPEEQTPSSPSPPSPPIEQDQGELAKASREEALRLAQECISPLIELTLALLGDGSVVKPQETALALGGGLMMSPGYRGLLLTGLKARGVEFGSVGVVSDAAGVGARGLAAVEFGLDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJV3</accession>
    <name>A0A1Y2BJV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_556553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJV3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJV3"/>
    <dbReference type="InParanoid" id="A0A1Y2BJV3"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="306" mass="33432" checksum="6320B5F0DC83E92F" modified="2017-08-30" version="1">MSVSKVIVVFGATGLQGRYLIEALSANNTRALTPWKIIALSRSSTSPSSTALAKLPGVHVVQVEQDVMEAPAKAFAATGIEKGKVYGCVSIQGYVDVEAMYRQGCAIGDAAKEWGVKHFVYSSSDVGNKGKAGIPAFDIKISVEEYLSTLFPDSHTYLRPAHFMEVWTSSDHQFRMVRTVTANIALKSNSSMKHQLVSVRDIGLAGAKAFIEGPSWCDGVVRLAGDGLTISELETIYTEVLWHPPVYDSVSLATELSSTVPFLQQIASFFGNQGYGIDIEACRRQLPEMEDLRAFLIRTRENERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJZ6</accession>
    <name>A0A1Y2BJZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nuclear segregation protein Bfr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_515666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJZ6"/>
    <dbReference type="FunCoup" id="A0A1Y2BJZ6">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJZ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJZ6"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="562" mass="61784" checksum="40301524A715756C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKP9</accession>
    <name>A0A1Y2BKP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_2077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKP9"/>
    <dbReference type="InParanoid" id="A0A1Y2BKP9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012056277" evidence="8">
        <location>
            <begin position="38"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
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    </feature>
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            <end position="204"/>
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            <begin position="274"/>
            <end position="296"/>
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            <begin position="316"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="343"/>
            <end position="363"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="523" mass="56756" checksum="65FB452A84375A83" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKS6</accession>
    <name>A0A1Y2BKS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_585654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKS6"/>
    <dbReference type="InParanoid" id="A0A1Y2BKS6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="323" mass="35423" checksum="D06F8549D8AEEB36" modified="2017-08-30" version="1">MNMVSGSSLMPSGNSQNTVENRWVELTPDAARFLQESVKYLPSIAFQQHYFPAGKDKVLYDPEQVGGSRGDSLLSNCYTGAFLEVNPSNGSSAYAQTSVCRFSHHLGVEIYPTEWVPQQQADLALESWNRHRNTNPVQIYCKQEPIMSLRSRDATTQALRPLSGETFEVENKEGHEFSAKWVIATAQGDLDRRTQDLLAELQGFQACLSIWANVSCVPISDTSSMRHTIGTSSMRPTIGARSSGQVVPRSSLRPSGAKFLPNILYRQPTVPSALLQYTGGPHMPRAPSSSRIITGITGSQTASAIEYGPPPPDSLYDVTRAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKY0</accession>
    <name>A0A1Y2BKY0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative phingosine N-acyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_509596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKY0"/>
    <dbReference type="FunCoup" id="A0A1Y2BKY0">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BKY0"/>
    <dbReference type="InParanoid" id="A0A1Y2BKY0"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="172"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY35426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="415" mass="48788" checksum="1CD3BC7031FCD9D9" modified="2017-08-30" version="1">MSSVKPANRRRSSSVTTALKQIPLNQQTQGHTSGSSTPASNSEVKPLRGSTRPRRSPDALPETYESLGFLKDVQTGRWMLVPSSAFKLMLLPDIFYFSFHFLQNQGYLSKDTTNPFEPLLWLSNKLPNGSYTKGWGDILFVLNHVIFWSFVRQTVTIHFLRPLAKYLGIRGQKIMRFTEQGYAIFYMGIAGCCGIYVMHGLPTWWYKTEHFWLEYPHREMSFELKLYYLMQFSYWLQQTIILAAKVEKPRKDFRELVMHHMVTLWLIGWSYGLYLTYIGVSIFVTMDISDVFLALAKCVNYVDEGASAPVFAVFVGVWTYFRHYLNIRVLWSVYTQFDLIPEQYRTRFAPLDDQWMDWWMKWQIFVPIFLLQCINVFWYFLILRILYRAVVVKTIADERSDDEGEEETSDKVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLQ5</accession>
    <name>A0A1Y2BLQ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_28368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLQ5"/>
    <dbReference type="InParanoid" id="A0A1Y2BLQ5"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY35698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="271" mass="30426" checksum="50727E6A77C3668C" modified="2017-08-30" version="1">MSFRDQSSSVSSLLEQLRATTTPSTVIPQSTVPSKRQLDDLLSSLNQPAPAPAPASSTQSAFLGARRNLIEPFGPVSNQPQPPPRQFYSTPSDDVERENAVAGPSSLRSSEKLSRGKKHPRDRRDEEGYAEMSFAKALPILTELLSEEEFKRELRRIKAEQNALERRLWAKQEKLKADHEKQVQSERDLAKISNRPLAPDKPAEWTRALKVLLAEMHRDRVLPSFDGLALRHRQRLEELGVPGLGGGAQLDEKARERVKRIMDVLEASLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM18</accession>
    <name>A0A1Y2BM18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_512317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM18"/>
    <dbReference type="FunCoup" id="A0A1Y2BM18">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BM18"/>
    <dbReference type="InParanoid" id="A0A1Y2BM18"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="557"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY35814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1137" mass="126949" checksum="495577EE8A169110" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMB2</accession>
    <name>A0A1Y2BMB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavo protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_29736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMB2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BMB2"/>
    <dbReference type="InParanoid" id="A0A1Y2BMB2"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="232" mass="24978" checksum="90EE3D5D79F4E627" modified="2017-08-30" version="1">MSTSLRIAILTGSSRPHSNNAGIAEWVQDRVIRLLSKTSSSTTTDSITTTPLVPILDHRTDPLPLGPLIDDIVPQGLIGIPSPTDSTLEYPYPSARTREFSRIIQKLDALIIVTPQYNWSMPGELKNTIDHMFHEWVGLPTAVITLGGRGGGKAAETMNSILGGIRAQVVSCGVVGVALPRDTYISGDKRSTKDDVELLAPYEAALEGELLKVIQAAESRRKAKAAAAEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BMF0</accession>
    <name>A0A1Y2BMF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_32495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BMF0"/>
    <dbReference type="InParanoid" id="A0A1Y2BMF0"/>
    <dbReference type="OrthoDB" id="10656256at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38856" checksum="A98DF7D1FDDAC7A0" modified="2017-08-30" version="1">MEGMSRFAPIDLRSPSPDCASCESSKTDIAHSVRLENYNSRTQHRVKPSIHTLIEMPPTPPPEVTVFDTHQRRVPVPDSWGPLVTPFYRDRLPKLPKISDRKLRKAVIDRKTPQQGQRGVNDNGVHGWQELALHGDACLNAAIYRALLDANPENVDTKSMVAMRSMLASNNLFSYLAMAYEIAPGRGQKPAADAFEGYIGALDILEHTTTPSDSRPQSQSLSLREFLSTLFSPVVFPIMKQWHSQIDREILTHSVIECLRRSRRKKKFVVGKSVKKSGANRKKERKRRRAIPLPMPTTSKRATRSKRKMNNRKINPVREVIVISDSEDSEDSEESGSNSDSDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE25</accession>
    <name>A0A1Y2AE25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_554683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000124">
        <property type="protein sequence ID" value="ORY20828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE25"/>
    <dbReference type="InParanoid" id="A0A1Y2AE25"/>
    <dbReference type="OrthoDB" id="2596696at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY20828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="422" mass="47432" checksum="0A4F446A95A256BA" modified="2017-08-30" version="1">MGGNALTPFIASRLTTSQLNSLLLHARKSLEGYFNPIEIPRFLVDKVEHGDLDLLCGTDDVRLIESLKGIMERGSINDHQHDHESPHVESDNYQVESDKERQSPRAWCGSVCKALHGTMWKRNSAEIHIGVPASIIGSTLSPVDGYEPFYQIDLILLPRYQVPFARLALSFAITPMLLALILRSISRSLTLHRAEIVLRHAPFVGVPGIDIALTSDPRAFCDWLGLNYTTWLETEFTHEHDLWEWLVDTEPDSLAGGALKRLGTEWETIKLNPEIARARKRAKGGPSASARFIDWLKRPESNWYSPSPIPTAVPATQPQSEEHAIPTTPETITSSSETSTPNNLIDPDHPKQLSDRAKAAVVFWGKLEEYEKELASRLVTARELASNQRRRIEARHRKEEEERNLKQLTQTISAVSVVDPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AFQ6</accession>
    <name>A0A1Y2AFQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_570026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000118">
        <property type="protein sequence ID" value="ORY21097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AFQ6"/>
    <dbReference type="FunCoup" id="A0A1Y2AFQ6">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AFQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2AFQ6"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="40"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="353" mass="38439" checksum="C8C4647504385B54" modified="2017-08-30" version="1">MSSSTSELQSDANVNVTHEWVLGPEDTPFYTLRWSPASEKPKAYILFIHGFSEHIARYDSLFRRLASAPYYLHITAFDQRGHGRTSHAPLSAESPEVKEWKAQGKAVTIGKSTKRKTGGWAKVLPDIEWFVIREQEYIKQQGGGGKLFLWGFSMGGGQVLAFVTRPQKPPSEETVAFLSGLIAGGPMIRQTTPASVLQLKVGSIAASIGLGNMLIPAPVGWDFLSQNKESNERAKNDPFCEPVGSLRGLADMLNGGASLDSQSAYNHFPSDLPLLVYHGGGDKICDPAAARRFAEGAAAKDKTFKEFPGAYHEVHNELEPTPSELASLVGNWVLTRVDGLGAEERGQSQQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGB7</accession>
    <name>A0A1Y2AGB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">BCR39DRAFT_554016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000115">
        <property type="protein sequence ID" value="ORY21257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGB7"/>
    <dbReference type="FunCoup" id="A0A1Y2AGB7">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AGB7"/>
    <dbReference type="InParanoid" id="A0A1Y2AGB7"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY21257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="437" mass="47333" checksum="FADA7A2EC15B96C7" modified="2017-08-30" version="1">MPALQLIADLPPHSATAWAVTFNPTRPLLASCSTDMTFRIFHYILPSPSPSPSPSSSSSFFPSPDAPKPTFQLLNTVKTEHKRTVRSIAWAPSGRTLATGSFDSTVGIWEETDGDEGDDEMDDGQGGGIYRPRNGAGGNGKEWECVTALEGHESECKSVAWSHDGGLLASCSRDKSVWVWEVQPDDDFECIAVMMEHGQDVKHLAWHPKEEILASASYDSHIHLQFDDPDGDWCIFQKLHPKFPPAPLTISLESSSSRPIPVTRNLIDNLAPNDEEREAEEKVVVPPLEEDETVWSLAWSPDGQMLASGGDLGGIRIWTRKGHNPDSLFEETLHTSAHSRSCFSLSWATGGLPEDQGGRGLLASGGGDGKIVIWQVYVSPQSGKAELQPIAAMRDAHGVSDVNCVAWCVREDGKGAGLLSSAGDDGSVKVWRVVADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AHA0</accession>
    <name>A0A1Y2AHA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_48672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000101">
        <property type="protein sequence ID" value="ORY21953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AHA0"/>
    <dbReference type="InParanoid" id="A0A1Y2AHA0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="225" mass="24262" checksum="6C53F78E27DF4C05" modified="2017-08-30" version="1">MPPTEAIRKVYGVQTLGAIWKLVVMEAQFDGVDEAAISGGMASDENGHIDLSPHLFVVTTLWTGDLLDPQALLELVIILRDVRDEQIVRHELIGNWLYCLRDQDAPPARSRRRKPIATGSDSARAIKKSRNERGTDGGRIGPPGGDQSDSGLGLKSVGSTVADKLSRPSLHLDSIRNIMPLRDSTSYVVDWLSEQDSSSPQSSSGDFIEDTALPSKPPAPAAIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AIH2</accession>
    <name>A0A1Y2AIH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_591337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000094">
        <property type="protein sequence ID" value="ORY22389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AIH2"/>
    <dbReference type="InParanoid" id="A0A1Y2AIH2"/>
    <dbReference type="OrthoDB" id="2565199at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="37"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY22389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="490" mass="54092" checksum="62F05028907DC1DA" modified="2017-08-30" version="1">MLQVVSGSAPKYKNYNMSRDPRLNTSRLSSAFIPRKPKASLFQGLDFYVQPKGTRMLDFSNVCGLIEDFGGRICSQPCHKGPIIIIILDSFANGLASITKSNCRASEEIIRLSDWTGRELVKYFGKIKGAVPDQPREWCSVLKADWLRDCVNTGTLVPKAPWEIVGEIEFAPAGPPGSPTMKDTLPTKPVETSQEPALEPASASNVHQSDIRQGPEVATNESSKMMISQNSGRRPSRTSRSASFELDPLPPPAFTIGHRSISDQSQNRITSDPSQDRDSRHGSPNRDMPRQMHTFNPSQDQDSLHRSLERESSLQNQDRDTGPSQISSSSTSVIDCPQSPAPAPLKQERFLNQYGLPVTFHVLGGRNKAIFDIVLKNELSGYLTTATKAQFIIVPAGADVNLTSVQVAVVRDAIVDPTRAAVTSDWIDACIEQQRILEHQPFKFILQENLPLTPSSEAVSADFADSSRKRGSPFDTIERQSKRPVLELRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJT6</accession>
    <name>A0A1Y2AJT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_550886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJT6"/>
    <dbReference type="FunCoup" id="A0A1Y2AJT6">
        <property type="interactions" value="716"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJT6"/>
    <dbReference type="InParanoid" id="A0A1Y2AJT6"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="507"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY22764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="656" mass="73088" checksum="A34F3FAE7847472F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJX0</accession>
    <name>A0A1Y2AJX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_562224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJX0"/>
    <dbReference type="FunCoup" id="A0A1Y2AJX0">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJX0"/>
    <dbReference type="InParanoid" id="A0A1Y2AJX0"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY22772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="269" mass="28373" checksum="5D0CBD14901C5538" modified="2017-08-30" version="1">MSSVFNSSRLIGKTVLITGASAGIGASTAVLFGKAGCNLVLLARRADKLAAVKEQVLAAHKAGGAKEGGRVVVIEADMQKRSDLDAILGKLEGLKVDVLVNNAGMVKGREHVGDISDADIDVMIGTNVVGLIHLTQIFVREFKKQNSGMIINLGSIAGREAYAGGSIYCATKHAVSAFNGALLRELVNTPIRVTEIQPGMVETEFSVVRFRGDKAAADDVYKGLDPLTGEDIAEEIVWAASRPAHVNIAQVLVLPVAQASATINYKRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKD2</accession>
    <name>A0A1Y2AKD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_550861</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKD2"/>
    <dbReference type="FunCoup" id="A0A1Y2AKD2">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKD2"/>
    <dbReference type="InParanoid" id="A0A1Y2AKD2"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY22760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="329" mass="35892" checksum="FD6FF1423849F069" modified="2017-08-30" version="1">MPFTTEQINKASSSSSTPTPTPMSTSSSSSSNTQRIQPKCLKNKMDGTETGTTETEIQATTPRRRRRSQFRPCIDLHGGVVKQIVGGTLDLVSEDGKGPKENFVATQSPGYYAELYRLNSLRGGHIIKLGPKNDDAAREALAAWPRGMQLGGGVSLENAQEWLDAGAEKVIVTSWLFPEAKFDLDRLKSLSDKIGKDRLVVDISCRKRKDGWVVAMNGWKTLTDMTVSEESIKQLEQYCSELLIHAADVEGLCQGIDEELVERLGEWVTLPCTYAGGARDLSDLALVDWLSGGKVDLTFGSSLDIFGGTGVRFDELVEADRQAKISSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKN8</accession>
    <name>A0A1Y2AKN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_550170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000084">
        <property type="protein sequence ID" value="ORY23052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AKN8"/>
    <dbReference type="FunCoup" id="A0A1Y2AKN8">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKN8"/>
    <dbReference type="InParanoid" id="A0A1Y2AKN8"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY23052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="108" mass="11583" checksum="8DA9FFDAB7CDA9E5" modified="2017-08-30" version="1">MSRLGAEPRINARLIPQFKGQTVRFTAKVLKMSGDTATVESSDKQEVGVILARDTHIATTFVEIIAMVKDDLTLKCLTSIDLGDSIDMKAVNNVVDFANSSKGAGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMK1</accession>
    <name>A0A1Y2AMK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_349936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000079">
        <property type="protein sequence ID" value="ORY23447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMK1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AMK1"/>
    <dbReference type="InParanoid" id="A0A1Y2AMK1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547:SF2">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="644"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="928"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="890"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1261" mass="139856" checksum="BA3E54B9190674E9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANG0</accession>
    <name>A0A1Y2ANG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BCR39DRAFT_547807</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANG0"/>
    <dbReference type="FunCoup" id="A0A1Y2ANG0">
        <property type="interactions" value="683"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANG0"/>
    <dbReference type="InParanoid" id="A0A1Y2ANG0"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="65"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="246"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="413"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="488"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORY24052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="542" mass="58592" checksum="4BB122FCA54A6F73" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANG2</accession>
    <name>A0A1Y2ANG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000073">
        <property type="protein sequence ID" value="ORY24024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANG2"/>
    <dbReference type="InParanoid" id="A0A1Y2ANG2"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="281" mass="30170" checksum="DA0D72ED6BAC7A71" modified="2017-08-30" version="1">MHCTSSKDVTDTRLRGKTSHGYIITNSAPSLCHFSFVDYSPPDIQQHSTMAPKASRSSQRPLAPSSSASGINLAPGTSRSTSALSRRGTRRSASDIASTARASSTPDWKNQWNFYALNPKEVNIDDLLESEAPMRDGVKASTGGTYTGVGNTTATENALQSQDADITGATAGTGNVTTVGENATTLRRTQRRRAIQTLLDSEEGARETSVFAIASLASHPSSIIAISLNFQSPGKPCDVIAVTRDPERQEDLTAFRYEGGKESTRVLSQECVHFYLIVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQH0</accession>
    <name>A0A1Y2AQH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_545951</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQH0"/>
    <dbReference type="FunCoup" id="A0A1Y2AQH0">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQH0"/>
    <dbReference type="InParanoid" id="A0A1Y2AQH0"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY24791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="558" mass="61767" checksum="F908CCC5265A03A1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AR92</accession>
    <name>A0A1Y2AR92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">BCR39DRAFT_545476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AR92"/>
    <dbReference type="FunCoup" id="A0A1Y2AR92">
        <property type="interactions" value="720"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AR92"/>
    <dbReference type="InParanoid" id="A0A1Y2AR92"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="365"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY24984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="651" mass="73208" checksum="66B29AB83FD7BBFD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARL7</accession>
    <name>A0A1Y2ARL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_309677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000062">
        <property type="protein sequence ID" value="ORY24950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARL7"/>
    <dbReference type="FunCoup" id="A0A1Y2ARL7">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARL7"/>
    <dbReference type="InParanoid" id="A0A1Y2ARL7"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY24950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="191" mass="21134" checksum="8C31BE0AA172ECEC" modified="2017-08-30" version="1">MSSSNTLKRKVVIMGSPSVGKTSLTQQYIAPPTYNDNYFPTIESTSHKLVSFDGDEYDCEIIDSAGQDEYTLFPAKYAVGVHGYLLVYSINSRQSFEMVKTVHDKILDYAGVAKVPCVIVGQKSDLSAADRRVSVAEGEALAKKLGASFVESSARDNKNVGKAFEILLQVMQKEYNPKPEKKKSSWWPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARY1</accession>
    <name>A0A1Y2ARY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_485611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000059">
        <property type="protein sequence ID" value="ORY25236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARY1"/>
    <dbReference type="FunCoup" id="A0A1Y2ARY1">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARY1"/>
    <dbReference type="InParanoid" id="A0A1Y2ARY1"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111601" checksum="0234EBD7E6D0229A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASZ5</accession>
    <name>A0A1Y2ASZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_308787</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000061">
        <property type="protein sequence ID" value="ORY25065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASZ5"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASZ5"/>
    <dbReference type="InParanoid" id="A0A1Y2ASZ5"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012643780" evidence="13">
        <location>
            <begin position="21"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="261"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="390"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="291"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY25065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="454" mass="47953" checksum="75E796D8725F374A" modified="2017-08-30" version="1">MTGPILAALAVLLFSSSIRAHCTIWHESLYGYNFPYQSTDSNQNYDSEEVSNPLRRADNLTITKWWAHGLLDYPPPPDAVMNLPSGGVFQAEFSQSRHDSSMRDPSKTEKPLPDIAACNLHYSGPLVTSPPPIPSLLGGVALAVAYESDVTKIQPKDMVVFSVNVTAPFYRLTDFHIPIMPPCPGGRCHCSFNWIHLGMHNEGYPYERYNDLYVCNFTGPTDPSKTLEPGSGQIPVLCENDASLCVTGRKQPMYLYQVDGNNVVEPGPQQECPSHNSRYGFDDGAQMLWPDSTTSANDSSTADSSTAESSSISRSLSTDSTASTVASSTSINIPSNVSMSTSTSTSLSSTPIITTTNPASLGGDDNSVGSPSISAGGAFDASSSAVLSSSSSPVSSISSSIAPSLTTDTPTSPIVDLADGNSSSTANASSSTDPAASSPKTCPGSKRSRTRLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU76</accession>
    <name>A0A1Y2AU76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_566193</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000053">
        <property type="protein sequence ID" value="ORY25840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU76"/>
    <dbReference type="STRING" id="71784.A0A1Y2AU76"/>
    <dbReference type="InParanoid" id="A0A1Y2AU76"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY25840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="570" mass="63012" checksum="1A94E70F9886F2D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AU78</accession>
    <name>A0A1Y2AU78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_542320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AU78"/>
    <dbReference type="STRING" id="71784.A0A1Y2AU78"/>
    <dbReference type="InParanoid" id="A0A1Y2AU78"/>
    <dbReference type="OrthoDB" id="2564140at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="502" mass="55334" checksum="87DE0338716BC2F7" modified="2017-08-30" version="1">MVRLSFTLHHHRLSPEPIELVCEVTDGVLPAQQLERIATLVAEQIDKATTAAVGDRETLEVAKRTKVSLPRSQNGCLTCRRRRVKCDEAKPICTSCKRNPNRVCRYQVSIERHSRAVTASTSRISTPSVPAETIPPSAVKSPKVDVADVALLLSRPSSPLTLKTEANLLLLYHLSTVTFSMLGGGSNTRFRFAQLQQAWTLSLHSLLPCCVVAWAEHFNYVQPSRVDQKELSEKLRKEIMFKLSMLSIPEDGHGLEIEELNLILGAADLLATRDIIAADRDWRALLQFTVTLVQTHGGPEAIINRLSDPGKREAMRCMLLHHAAWELFSCLSTGTSPTLLAEGSTLWCEQDEACYAMIEQEFGISLPVLLTAAQVCDLVAATRSRGLQESIQSDAASLYAGLEEIWLATICASPNRPRIQSGNFLFRHTMICVVLRDVLGYSATHPRIRQSVSAIRELLIEAMVVNMAGGMMVGMLQPALVGGSMAAAEERDTFAVVLREMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUB0</accession>
    <name>A0A1Y2AUB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VIT family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_542214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUB0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUB0"/>
    <dbReference type="InParanoid" id="A0A1Y2AUB0"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="373" mass="39297" checksum="2255F2851211D468" modified="2017-08-30" version="1">MSSSCCGSGKCCQRPENQQSPPAPTSVALPSRSTPKPATTEPVWAVEPPAATRDAQLENILGDSEPLVSKCGADARANGQCCRDLKGEDERHLIPPEIVRDVIIGLSDGLTVPFALTAGLSSLGSSSLVVTGGLAELCAGAISMGLGGYLASQAELDHFHYLRRHTQARVLRSCAGEMDREVHSILGPLGVKEPLSRLVAEHLREVEDDAWGQRTEGTEGIMSAAQRRGSDGKKKHWLSWNQQKDADGLENGGTKGNEEMGLTAFLLKFGEGLEEVPVSRLYISALTIGLSYFIGGLIPLIPYMATSNAEDGLIISCILTGLILFIFGGFKTYFTGATGGAWGYIYGATSTMVVGGLAAGAAFGLVKALGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUF0</accession>
    <name>A0A1Y2AUF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_498529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUF0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUF0"/>
    <dbReference type="InParanoid" id="A0A1Y2AUF0"/>
    <dbReference type="OrthoDB" id="4506189at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY26172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="312" mass="34047" checksum="F6EDC21CD5643F9B" modified="2017-08-30" version="1">MIALAESNLPKQPSKQVLRSAKAAASSPHGLINLTRLVKALDEAVDGPAEDPIALRKEWETVQYARVLLNSLRTANEQSSSTNISLEDLDSTLYRIERSYSAAVTSPSIHARKSSFGIPPVPAKVLQPEPAEKIPLPSSPAPPAPSEMMNESHPPPAAALRQRHVPNMAVTDYLRRRQEEDSAGDETGLLPLKVHHPSRPGNNQGARDALLDGARATMGSKELHEELGGQLADMSHRLKLNAIHFASSLEEEKSLLEISQDVLEKNLASTRSSKKTLTAVSKKGRGTTCMTLGVVFMVIVLFVWTYMLIRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVP9</accession>
    <name>A0A1Y2AVP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_540408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVP9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVP9"/>
    <dbReference type="InParanoid" id="A0A1Y2AVP9"/>
    <dbReference type="OrthoDB" id="2594812at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1015" mass="105988" checksum="732172A69068013A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWU7</accession>
    <name>A0A1Y2AWU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_540158</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWU7"/>
    <dbReference type="FunCoup" id="A0A1Y2AWU7">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWU7"/>
    <dbReference type="InParanoid" id="A0A1Y2AWU7"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="364"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY26770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="699" mass="76453" checksum="C32637744146BAF4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX08</accession>
    <name>A0A1Y2AX08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX08"/>
    <dbReference type="InParanoid" id="A0A1Y2AX08"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38029" checksum="19EA16CB5B0AAB64" modified="2017-08-30" version="1">MYRSAESTATLTQMDAPNGTLRLRGDSPMSELRCNGYAVVHGAIPPDRAARYVNEIYRWLESVGKGFKADDRDTWHVQCMPRFQKGGLYKRYGVAHEQFAWDIRTEPAVIDAFAQIWGTDELLVSFDAINASFPFPSDELGQAAKPWPHVDQSPTRSSMHCIQGIINLLENGPDDGGLMVLEGSMSLFAEFFRAHPQLRPEEGWPEIDWYSHSDDTLQWFYERGCKWKKIEAGPGDLILWDSRMIHYGDAAKGDRPRVATYVCYKPAKTITSEKLEAKKECFRERWGTSHDPLNFRISRPNAGDYTLEPKESVYPRRGPTLSERALKLAGIVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX75</accession>
    <name>A0A1Y2AX75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_560196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000041">
        <property type="protein sequence ID" value="ORY27096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX75"/>
    <dbReference type="STRING" id="71784.A0A1Y2AX75"/>
    <dbReference type="InParanoid" id="A0A1Y2AX75"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY27096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="336" mass="36764" checksum="A037BFC05FE0BCCA" modified="2017-08-30" version="1">MSFIRICAVQAESAWLDLEAGVDKTCALIKEAGEKGCHIIGFSEVFIPGFPFSIYTKAPDEEWILKYQKNSLVLGSPQYNKIRKACRDAKVWAVVGFSERDGSTLYLGQSFIGPTGQVHLHRRKLKPTHVERYVYGDGQAESLTTCVTTDKGVVLGGLNCWEHLQPLLRYHHYNQGVQVHVAAWPYVCPAGPGVPMSSCSDISGDVISRMLAIEGGAFVMTCTAVISKEGSKIMNLDPERAGPAAVALEGGGFTAIYGPKGDVLARSKDQFSEELVIADVDLDDIHRHKQMADCIGHYSRPDLLSLHVATGEMPRVSYSDGRHNKTFAEKLAPLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXG0</accession>
    <name>A0A1Y2AXG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_599556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000042">
        <property type="protein sequence ID" value="ORY26970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXG0"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXG0"/>
    <dbReference type="InParanoid" id="A0A1Y2AXG0"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY26970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31461" checksum="9D24513BA704B5EB" modified="2017-08-30" version="1">MVHTHTVGLIGHTGNIGKQILKHLIKPYEDGKLNIIILHRAGSDLSSVPKGIETRQVDISKPVDVALLVGINTLVTAVAFEVMGNTVNLVDAFAKSPDAVTFIPSYYSAAWSEADIAIPQMAVVNQHFLPPIQKAKEAGVGVTIVHSGLFSEYLFVIPFVGASLKDNTIQANAAMLEKTFPIITHEYLGAGIAQLVTNPPETIKDKSYSFIEYQVKGQGLVEAFEAVNGSKPTIIDFTEKDYEEGLNNPMGPIGTLYKAHWSTGELVYPNETKPEGITSKSLVELAKIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXN2</accession>
    <name>A0A1Y2AXN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_469418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXN2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AXN2"/>
    <dbReference type="InParanoid" id="A0A1Y2AXN2"/>
    <dbReference type="OrthoDB" id="2863306at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118837" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12775" checksum="25853488FEE1C722" modified="2017-08-30" version="1">MKLTIFLLATVLSMAANVKADYYANFYDDDGCKINGGEGVSIKNPGCLTEPNRGSVYIPNTGLGTLSDNQFCLVKTHYDGSCSCQNEGYDFTATGFCAVLDPSYQSYRFISGGCASNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXR8</accession>
    <name>A0A1Y2AXR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_538480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXR8"/>
    <dbReference type="FunCoup" id="A0A1Y2AXR8">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXR8"/>
    <dbReference type="InParanoid" id="A0A1Y2AXR8"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="108"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="354" mass="38767" checksum="B2A65C046188AACA" modified="2017-08-30" version="1">MLGWLLKPFALASTIALSTLGILSQKYQRARFYFHLILYISTLGAMSIWGVAVSILATLAGQRLNINYYVARSFYLTCSPLVGIKIDVEGEEHLTGLLTARGGNPQSAVLVGNHQSFLDILFIGRIFPKRASIMAKKELKWVPALGQFMSLSGAVFIDRKNRKDAVKALEQAANDMKHKGVSLWVFPEGTRSSSAEPALLPFKKGAFHLAIQAQVPIVPVVSENYHRLFDGRTRLDSGTLRVKVLPAIETIGLTSDDVNSLAEKTRERMLETLSEISAPGPSTSATKQVEELPETSPALEETPETIRQRPVAQASESSESGKEGGKLFKVDSRGDTTEDEMDDDAVLLKRPKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXZ0</accession>
    <name>A0A1Y2AXZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic amino acid beta-eliminating lyase/threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_594651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXZ0"/>
    <dbReference type="FunCoup" id="A0A1Y2AXZ0">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AXZ0"/>
    <dbReference type="InParanoid" id="A0A1Y2AXZ0"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="327" mass="35078" checksum="38E28975CCB494C2" modified="2017-08-30" version="1">MPTDAQLLYAIGASRGDDGYSEDETTNAFEARIAKLAGKEAALFGMSGTMTNQLAVRSHVKQPPHSVITDHRAHIHKNEAGGIAIFSQATTHALVPANGLHLTMADIESNLQLGTDRCVAPTRLICLENTLSGMIAPQSDIVAIGRLAKRHGLAMHLDGARIWNVAAAVLPWTYSGLTRRLSELLEPFDSASMCLSKGLGAPVGSVLVGTKEYINRARWFRTPFGGGIRQAGCILTASADYALTHHFRLLAGTHLLAKRLSEGLEELGCQILAPVETNMVFFDASPIGLTMKNIAVCLAALPDPIRILEVGRCVIHHQISPQAARIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AY21</accession>
    <name>A0A1Y2AY21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_469326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000038">
        <property type="protein sequence ID" value="ORY27479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AY21"/>
    <dbReference type="FunCoup" id="A0A1Y2AY21">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AY21"/>
    <dbReference type="InParanoid" id="A0A1Y2AY21"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="104"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="335"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="719" mass="79062" checksum="49AA7BE5829EA3BF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYF0</accession>
    <name>A0A1Y2AYF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_560053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYF0"/>
    <dbReference type="InParanoid" id="A0A1Y2AYF0"/>
    <dbReference type="OrthoDB" id="2576593at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="254" mass="28320" checksum="7EA497B804B6646A" modified="2017-08-30" version="1">MTKKQSAAEYKSPFASVAIGGLRYWFSLILLFISWALLVWVYFFNVPLVGTNNQKDSNMDILGWLIQLHSAGKIYGFGVWGICLWSEDGNGDTTCWKSAFWTVPENASDGPTAGLSLPSSIANSLGIAGALLFFPFITHLFFMAVYLFTFHVPVLDQPPRQVKVVSADGKESTKLAWPWTKVDGEPRSKRLWCARLVRHPIYIASLLVFNTTWILTTFICAYVGKSQVSNNYQAHIGRGTNLSVSSLDILLQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AYU4</accession>
    <name>A0A1Y2AYU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_506187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AYU4"/>
    <dbReference type="InParanoid" id="A0A1Y2AYU4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="230" mass="26203" checksum="9CF239FB04E5FAA8" modified="2017-08-30" version="1">MPHQTITEDTGGAVRDPTQDSRQCVTPHPVQKPHQWLSKVWPLHHRMYEKEGCEICLPHVLQRTSQLVFHSANRTRTYPSSCELTGPNSWMILQFEEKMMFLKAPAESYPDSSKEEYISHADTLTLFGSASTLQLSFPLCKHSPYELLLWQGRLLMKEVHLQLDQGSVQRIRFSASREDKGSITYSTGEVLLEWNDHVNRIQRGKTSVEKLFGGLGQNAKISGKAVEPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZA2</accession>
    <name>A0A1Y2AZA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_216530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZA2"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZA2"/>
    <dbReference type="InParanoid" id="A0A1Y2AZA2"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="55"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY27901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="359" mass="40244" checksum="FA4462BC12A69E39" modified="2017-08-30" version="1">MPVAVAPVNPIESLKTALNGTSIEEPVDLREYAHFDATPSIGTEFRTTSSDGQPILSIRQVLEDERKLKALGRLVSERGVVFFREAIITPEEQIELVDKLGKAGGKPETSRLHIHPLTVEGSELGDEISVIDNRFVFDDKFKRDDFEILQRPAGQTLWHSDITFEPVPSDYASLQIRTLPSVGGDTLWASAYEAYDRLSPAYKTFLEGLTATHRGDGFVEIARRSNATLRENRGSPLNIGQTLETVHPVIRTNPVTGWKGLFVNRGFTKRINELTKPESDKTLDFLFEHISANHDLQVRFRWETNSLAIWDNRSTFHAATQDVDHQIRNGTRSVSLGEKPYLDPASTGRREALAKAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZM8</accession>
    <name>A0A1Y2AZM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_225608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000037">
        <property type="protein sequence ID" value="ORY27687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZM8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZM8"/>
    <dbReference type="InParanoid" id="A0A1Y2AZM8"/>
    <dbReference type="OrthoDB" id="2561385at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="845" mass="92783" checksum="AC6FABB807D4FDCC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZP1</accession>
    <name>A0A1Y2AZP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_559732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZP1"/>
    <dbReference type="STRING" id="71784.A0A1Y2AZP1"/>
    <dbReference type="InParanoid" id="A0A1Y2AZP1"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY28032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="242" mass="26921" checksum="C5F1277A199827EA" modified="2017-08-30" version="1">MAESELQTYRDQLAYVNLSLETDPNNDDLLKLKTELVELIELTQIALGASAASSSKPAVDASKSKGKGKETSNWQDNGAYKAGMDCMAKYKDGKWYPARISAVTGSQESPLYTITFKGYTSTTNVPVTSLRPHDPSAPIPQPQKRKPEDLSEREKERKKKKGEKWMESQKARSDEVKDKKNAWEKFGKKASKKGIHISGLEGKSVFRTPDNPFGRVGVVGSGRGVTEYERMGKHKFDDAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZV9</accession>
    <name>A0A1Y2AZV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_505947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZV9"/>
    <dbReference type="InParanoid" id="A0A1Y2AZV9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="102" mass="11237" checksum="D4D2F9B45FD1D1FA" modified="2017-08-30" version="1">MSDDNSNAQSGSSGLSTGAEVGIAVAAVAVILLLGSYILHRKGYISQRCRECREKFLPEMMKNGQKRFLLWTSHVWRHSETLKILTTPERSVRMKGSIGDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZW9</accession>
    <name>A0A1Y2AZW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_535598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZW9"/>
    <dbReference type="InParanoid" id="A0A1Y2AZW9"/>
    <dbReference type="OrthoDB" id="2593594at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="700" mass="69558" checksum="71A4776D6D5D2C13" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B098</accession>
    <name>A0A1Y2B098_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_565415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B098"/>
    <dbReference type="FunCoup" id="A0A1Y2B098">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B098"/>
    <dbReference type="InParanoid" id="A0A1Y2B098"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="134" mass="15423" checksum="658693C5DF3F2BBE" modified="2017-08-30" version="1">MLASLVRRATASSMPLPSSVTDASVQLIPPIPLYRRLLRVHRSLPPEMRYLGDSYIKTEFRLTRSTDNPLHIIGFLSQWKHYLDDLETAAQKKEGGEIKWSGRRLDTDNLDKMSPEQVGQLYELMHATKDVWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0W1</accession>
    <name>A0A1Y2B0W1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxidase</fullName>
            <ecNumber evidence="13">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_534899</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0W1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B0W1"/>
    <dbReference type="InParanoid" id="A0A1Y2B0W1"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="125"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY28488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="376" mass="41173" checksum="4DB2B290CD6892C9" modified="2017-08-30" version="1">MSVRVAPLLRATAGRRIQTAAPSFRSVTFKRGFAEGGPNVPPPSPPRKSSSPYALVGVGVVALGAAYLFFGTSGSANDTAKELGSKARGVAAAVEGKVGLRHSQEDYQKVYDKIADTLEVEGYDDGSLAPVLIRLAWHASGTYDKEDNTGGSNYATMRFKAEASHGANNGLNVARDHMEKIKQEFPWISYGDLWTLGGVCAVQESGGPKIPWRPGRIDGFETNVTPDGRLPDGSKAEDHLRFIFYRMGFNDQEIVALSGAHAMGRCHADRSGFDGPWTFSPVTFSNEYYKLLLDEKWGWKKWNGPAQYEDKKTKSLMMLPSDMALIKDKTFKKYAKQYAESEEAFFKDFSAAFSKLIELGVPTSQFAGDGWTMGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Z8</accession>
    <name>A0A1Y2B0Z8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HIT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_468247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Z8"/>
    <dbReference type="FunCoup" id="A0A1Y2B0Z8">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0Z8"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Z8"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="1">
        <location>
            <begin position="163"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY28509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="246" mass="28549" checksum="1E1DF1FDF2C8823A" modified="2017-08-30" version="1">MSSSLNILRTYATLPNPRKSLPPTTLLTSNPNTIVIFDAFPKAKYHFLVLPRYPFRRQGGDPEDNHSLVKLDQLDDLKSLLTKVGNRDVREQVVNTLADAARDVEEMIRDEMVKTEGFEWKIDIGFHAIPSMKHLHLHVISDDRISPAFKTKRHLNSFRQDLGFFIPIMEVQRWVTQEDWYVKERGLYDAENLLSAPLTCPKCDEPFHSMPKLKKHLENEFAEEKASMLKRIRNTGTQRSSDEELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B183</accession>
    <name>A0A1Y2B183_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_598969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B183"/>
    <dbReference type="InParanoid" id="A0A1Y2B183"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1040" mass="112397" checksum="814E92F94530A393" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B198</accession>
    <name>A0A1Y2B198_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_534412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000030">
        <property type="protein sequence ID" value="ORY28618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B198"/>
    <dbReference type="FunCoup" id="A0A1Y2B198">
        <property type="interactions" value="615"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B198"/>
    <dbReference type="InParanoid" id="A0A1Y2B198"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="478"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="769"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="837"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY28618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1226" mass="136883" checksum="720B5A9DFC93C65C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2V2</accession>
    <name>A0A1Y2B2V2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_178472</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B2V2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B2V2"/>
    <dbReference type="InParanoid" id="A0A1Y2B2V2"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="162"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY29143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="304" mass="35197" checksum="87636B9932F09F85" modified="2017-08-30" version="1">MVHAPEVTEYMKREASKLDVISDGVDAVNKIKGQKFDDGSKFDTGKDKATFRRYEEACDRVKNFYAEQHAKQTLEYNLRMRDQFKNTVRARMSVWEAMEMLNTLVDESDPDTSVGQIEHLLQTAEAMRRDGKPEWMQVTGLVHDLGKLLCFFGAEGQWDVVGDTFVVGCKFSDKIIYPDTFKANPDYYDEKLQTENGIYEPGCGLDNVLISWGHDEYLADICRKQSTLPKEAISMIRYHSFYPWHREGAYQHLMNEDDKIQLQAVQAFNPYDLYSKSDAPPVVEELKPYYQGLIAKFFPDEIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B329</accession>
    <name>A0A1Y2B329_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_180863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B329"/>
    <dbReference type="InParanoid" id="A0A1Y2B329"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="256"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="477" mass="51541" checksum="00AB3A96D7B6685D" modified="2017-08-30" version="1">MGSPSTTPGCFGAFFRQQHRTDSRTTSAADLSRMKPTAVPVQSSHGLLEPCICHERVINHPFYPRHQEDLPAYHSIRTTFNADAKKTIVDEIAKHTDELMVIQSYLSDNPEINYQEHKAHDKLTSYLESKGFSVEKHFLLPTAWRATFVHGKGGRTFGFNSEMDALPGIGHACGHNLIAVCGIAAFMGVAKALVAHDIPGKVILLGTPAEEGGAGKVALLDKGGYEGIDACMMNHPGGHQAGAGRIAPTMAMQLIWVEYTGKTSHAASAPWDGINALDAATLAYASISAMRQQIKPTDRIHGIITNGGQAPNIIPEHTQMKFFARAVNVAALDELLKKILPIFDAAAKATGCQVKVWTESMQKDLNNVRPLAEEYAAAMGELFNIPVDLHFELESGGSTDFGNVTYAMPACHPMFGIDHDPARANHTPEFTARARTPGAHKEAMKAAAGMACVGMRFLGDKAFADDTKSSWKKAVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3G6</accession>
    <name>A0A1Y2B3G6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_532557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3G6"/>
    <dbReference type="FunCoup" id="A0A1Y2B3G6">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3G6"/>
    <dbReference type="InParanoid" id="A0A1Y2B3G6"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY29373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="205" mass="23487" checksum="70DA4002AE48815D" modified="2017-08-30" version="1">MVKHNNELPKNHFHKDWQRRVKTWFDQPGKKKSRRVARSKKALASGAQPLERLRPAVRCPTQRYNIRLRTGRGFTLAELKEAGIRKKEAKGLGIVIDSRRRTKSEEGLTLNVERLKEYQSRLVVFPRKAGKPKSGDAQGEDLTAHITRAIPAIPSGYTAEAPRAIEEEEKEFEAYRTLRDARAAQRHEGARKKREADKAATEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B491</accession>
    <name>A0A1Y2B491_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_467328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B491"/>
    <dbReference type="FunCoup" id="A0A1Y2B491">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B491"/>
    <dbReference type="InParanoid" id="A0A1Y2B491"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="190" mass="22411" checksum="1A77872C07404F53" modified="2017-08-30" version="1">MGNKHTKLSPDELADLQKNTYFDKKELQQWYKGFIKDCPGGQLNKEEFKKIYRQFFPFGDPSQFADYVFNVFDEDKSGTIEFKEFICALSVTSRGRLDEKLKWAFQLYDINHDGFITYDEMLQIVRSIYKMTGQMVRLPEDEDTPEKRVDKIFRNMDMNKDARLTFDEFKEGSKQDPTIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B494</accession>
    <name>A0A1Y2B494_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Complex I intermediate-associated protein 30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_531455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B494"/>
    <dbReference type="STRING" id="71784.A0A1Y2B494"/>
    <dbReference type="InParanoid" id="A0A1Y2B494"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="1">
        <location>
            <begin position="53"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="366" mass="40266" checksum="64E615A394D5AABC" modified="2017-08-30" version="1">MAKPPSQFRQMLERSVKSIQRQTAAVVAMEPTSIYPPQHIYSFTSTQPPVEPIYNIATGSDVDIGGASTCHLTPVPIASSSSSSASIEQSHLAFHGTMSLKFPPAMQGRLSGAYAAFRNKARRMLIGEDMWNLQGYTHLRIVVGYRGWDGWRSRWSCNVQTDSLIKTDLWQHRLDIPPSSTSTPSADELDPLSGPSPTFTTLHLPLSSFVLTNAGETAEDQVPIDLEKIRTIGFGLLGAGRGTDGMPLLGRPPEQISRIATEEEERLMVGEEGLKYLASGSVDAMIDSRRGRKPEVSREVPIAASKYHRVSSHRQSTAAPIGEKDEVEIRTSVEVRPDSEGYYELCLKSVEAVKWDPANDELEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4T0</accession>
    <name>A0A1Y2B4T0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_532132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4T0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B4T0"/>
    <dbReference type="InParanoid" id="A0A1Y2B4T0"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="43"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY29560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="473" mass="50944" checksum="4A223F08998FCE6C" modified="2017-08-30" version="1">MGTASLNFAIAPAVDDTEAPPIPKARAWAETYLSSSLSSSSPLLDLSQGVPRSAPHPEVLSSLSSISASPSAARYGPILGEPELRSSVATEIQNQYLTSNVLSEDIAITAGCNMAFLVLLMVVCPPKTSIMLPLPAYFNQSMCASLQSLNVVYIPAVPDKGFTASIESARISLEKDKKQVSSGTGLPGGQGGDGREGTGRVGEGNGQGKIRMIVLVSPSNPTGTIYNHQQLKEWYDLAKEFKVALVLDETYRDFVQGPNGNGIGQPHTLFDEPDWRGTLVCVGSFSKGYRIPGHRLGSIIASPVLLKRITTVCDCMQICAPRPPQLALAPLLAKLRSDLLESSAQLSHRRRLFSETVNSVPGWSVDSIGGYFAYVSFPAAYLHASSVLGLKRKQLGSEDVARVLATRVGVVTLPGAFFMPPLNADDVWEEIVDGDMLRQDRWLRFAVANVEDDVVLQLGPRLKQMNELMGMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4T6</accession>
    <name>A0A1Y2B4T6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_531690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000025">
        <property type="protein sequence ID" value="ORY29497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4T6"/>
    <dbReference type="FunCoup" id="A0A1Y2B4T6">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B4T6"/>
    <dbReference type="InParanoid" id="A0A1Y2B4T6"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="424"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="588" mass="64164" checksum="6E0165434C6CB1E6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5Q7</accession>
    <name>A0A1Y2B5Q7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SUR7/PalI family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_531136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000023">
        <property type="protein sequence ID" value="ORY29817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5Q7"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5Q7"/>
    <dbReference type="InParanoid" id="A0A1Y2B5Q7"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012688800" evidence="6">
        <location>
            <begin position="27"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY29817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="243" mass="25939" checksum="56B7318C0684FCEB" modified="2017-08-30" version="1">MLARAAFPSFFFTLGAFILLLLVTLSAPVIKSIELLHVEDSNGATVANFGVLGVCYPGGVAKILGITISDDALCPPAHVGYEINSTLFGQNTNSHVETIATKSLTGSLILNTIAAGVAGVSLFFAFFAWFCSSRFMEIFTFLTLLVSSVVAWVAFWLDIGLALVARHMIGDVTNKAFTGHLGNGIWMALAGALSLSFAICLAGCGSFGRYSERYASREIVPGNEKGYRRGWLGRGTPAYRGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6K1</accession>
    <name>A0A1Y2B6K1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_558632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000020">
        <property type="protein sequence ID" value="ORY30354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6K1"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6K1"/>
    <dbReference type="InParanoid" id="A0A1Y2B6K1"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY30354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="146" mass="15628" checksum="F92E2931F3E6A8AF" modified="2017-08-30" version="1">MTLARIAQRAAASSSRAAARPIIANFSSSSSFLAESSASSSSVAPTAASGSRSLKKKKTVISECAPGTVLSGLTIYKNKPDPIAKADEEYPDWLWTLLDEEKASVLASQPKQEVKPGQAMNFEAERKRLRALNKARIKAANFIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6S9</accession>
    <name>A0A1Y2B6S9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_528616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6S9"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6S9"/>
    <dbReference type="InParanoid" id="A0A1Y2B6S9"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="268" mass="29625" checksum="402F5050C5967AED" modified="2017-08-30" version="1">MPPRPSPSPALADPFSALDPSLHPATLHSIATSRRSPSPPDTTRLTDFAQHILGETGFGELLEAAREEENQREIAGVGDGPGEDHGLGHGGGIDVDVDVDGEGEGGEFVPEGEDVDVPPPPPRAYGGRKRRREDVEGVDPVRSKKDSHKEVERRRRDNINDGLTELASLLPEGAAKRGKSELLRHATRHLAEVNAKAYEYDRDMAKRDAEKAELQAELEHTRASVSDERKRSIRFETSWREAENRAAQSQFELQRVKQELEDLRKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B7N5</accession>
    <name>A0A1Y2B7N5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_528683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B7N5"/>
    <dbReference type="FunCoup" id="A0A1Y2B7N5">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B7N5"/>
    <dbReference type="InParanoid" id="A0A1Y2B7N5"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY30550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="611" mass="67316" checksum="2888644B7CA172E9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B8Y2</accession>
    <name>A0A1Y2B8Y2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_465990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000016">
        <property type="protein sequence ID" value="ORY31308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B8Y2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B8Y2"/>
    <dbReference type="InParanoid" id="A0A1Y2B8Y2"/>
    <dbReference type="OrthoDB" id="3365519at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY31308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="172" mass="19317" checksum="AF692809F9C30EB8" modified="2017-08-30" version="1" fragment="single">INTAIRQPQTTEHVLLFVPFIKHKLVPLEYKYCNTGHLPAYLDAFTLPPSYYHPFLPSPQILFLDLAPFAEPAQKSLRLAFDRRDVITASGAILNAKRYLHVTGFEVSAAPAAQEWFGMVTLEAEGTAEGRRDLERRIGSGDPTRAVMGPWEVVREKSMLGAIWLRLVPETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BA39</accession>
    <name>A0A1Y2BA39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_88836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BA39"/>
    <dbReference type="STRING" id="71784.A0A1Y2BA39"/>
    <dbReference type="InParanoid" id="A0A1Y2BA39"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="974"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1230" mass="129267" checksum="D56B3850D8B880B8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAR1</accession>
    <name>A0A1Y2BAR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bacterial low temperature requirement A protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_524717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAR1"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAR1"/>
    <dbReference type="InParanoid" id="A0A1Y2BAR1"/>
    <dbReference type="OrthoDB" id="3243926at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="355"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="393"/>
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            <end position="437"/>
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        <location>
            <begin position="575"/>
            <end position="593"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
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        <location>
            <begin position="656"/>
            <end position="676"/>
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    </feature>
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            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="80006" checksum="8B00F08282759025" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB47</accession>
    <name>A0A1Y2BB47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_450386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y2BB47">
        <property type="interactions" value="147"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY31936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="89" mass="9483" checksum="B5ACF32F2A3F3BBC" modified="2017-08-30" version="1" fragment="single">SSFTRPGPPPLPASDQAEFDNLLKSHQTVGATPAATAPSAELEQHRDLRRGPKKDFEGEVNPKTGEIGGPKVDPFKAGDGDWQYGGRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB80</accession>
    <name>A0A1Y2BB80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_80831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BB80"/>
    <dbReference type="STRING" id="71784.A0A1Y2BB80"/>
    <dbReference type="InParanoid" id="A0A1Y2BB80"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="212"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY31810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="473" mass="52466" checksum="3939B452515D3502" modified="2017-08-30" version="1">MSSYPTRSKPPFNRGLTTPPPTSHDHDHAHDYFSTSPVITAKSPSFHRQGSMFMRHQRRGMTVEDLASMKVISDENRSKLFEGIPIGEKEIKSLPRKLRPYYENLALLHEHYAEVDGLLSGELPSAIAKSFQPAHSAFKVGRKSYTRMICDLEEEVADSPALALSRHESAWRINGRGGEDDEAEVGEGTGLLDGQKRDQRRERIAKLALNINTVVNVLLVAAKAVAVLYSSSISLTASLVDSALDLLSTLIILGTSWAIGVKGDRHRYPAGKRRFEPLGVLIFSVAMIASFVQVFIESFERARAPADEAPVELSKIGIATMLATIIIKLILWQWCSRIPSSGVQALAQDAENDVWFNIMSLAFPFVGTKLSWRLLDPIGGMVLSTYIIVEWVKTLLENFANLSGKAATRDQITRVLYLVSRFTPVQEIGDVECYHIGDDLIVEIDVILPKSSTLHFAHDIGETIQCVLERCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBS8</accession>
    <name>A0A1Y2BBS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_523766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBS8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BBS8"/>
    <dbReference type="InParanoid" id="A0A1Y2BBS8"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY32288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="789" mass="87073" checksum="9359E45256A5C72E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCA0</accession>
    <name>A0A1Y2BCA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_524185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCA0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCA0"/>
    <dbReference type="InParanoid" id="A0A1Y2BCA0"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY32107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="316" mass="35258" checksum="3177A291033FFDEA" modified="2017-08-30" version="1">MSSYDPEPELITPSQFRESMRLVRLQIAIPISVLVALGANLVCALAIKPGLKGINELNPTLLTPNSYMVGIFWAFLYILQVGFCMVLLLVRKDVTKETLVNGVGLRFAIANWLQAAWAVCWSLQFFIGAEVLILLNVINVLSIHLTLLMYPPTLRRPIDALFIHAPMTMLLAILLELDWMHNGFVALGWDIREEKSREKYTWQAVACIAAVNIVVALWAGFRRIYLLTAASVYILFCLLFSSPRTNPTLPTTALPKPTALLVTLIICLVLHPVSLLAGVAWKRTSEREGRIRLEEEVEAAEEDERHAEADAAVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCM0</accession>
    <name>A0A1Y2BCM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tom7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_522536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCM0"/>
    <dbReference type="FunCoup" id="A0A1Y2BCM0">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCM0"/>
    <dbReference type="InParanoid" id="A0A1Y2BCM0"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="52" mass="5710" checksum="D0A4884C0C0B4A91" modified="2017-08-30" version="1">MAFSDETKDRFNAAVGVAKTIITVGWIPMIIYIGYRNSSPQPSLIKLITPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCM2</accession>
    <name>A0A1Y2BCM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome regulatory subunit C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_522934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCM2"/>
    <dbReference type="FunCoup" id="A0A1Y2BCM2">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCM2"/>
    <dbReference type="InParanoid" id="A0A1Y2BCM2"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="262"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY32573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="512" mass="57721" checksum="CC4CBC24B6803AED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCR0</accession>
    <name>A0A1Y2BCR0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PI31 proteasome regulator N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BCR39DRAFT_504268</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCR0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCR0"/>
    <dbReference type="InParanoid" id="A0A1Y2BCR0"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="265"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY32544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="417" mass="42564" checksum="7D7F70D53FA084BF" modified="2017-08-30" version="1">MSNPLDPAHLITLISSILPRGTSSPLPRPTDALAALVHAIHTALNFRLVVTPPADPPNASSSAPSASVQDPPSAEDFDDGASETTTAVDQDEDLSSSPLPENSLAEGWNVRGEDAYAFEYRHEQSSMVFRVRVGRMGGRVQVDATAEDGAPHSLSVILSDLIDTSAFPTPSSATASVSSTASPAKSIGFISIESIVAFVEQYKREIIAHILPGVFTETLPSGSDPRNPPPAGQTRQPAPARPDPLLDPINPLRSGPSYPRNPASVGHRDLDPLAAFQPPGTFDGGGMYVDFNHPLFDGRRGGGRGNPDLDLQGGPGGMIQPPGSRWDPVGPGMGGGLRDPLQGGHDYGDELPPPGEFGPDLGRLGGMGGRGRGRGRGGFPGGGGFPGMGGGFGGGRGGGGGGGGGGFGGGFGGGMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCR9</accession>
    <name>A0A1Y2BCR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_522813</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCR9"/>
    <dbReference type="FunCoup" id="A0A1Y2BCR9">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BCR9"/>
    <dbReference type="InParanoid" id="A0A1Y2BCR9"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY32554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="70" mass="7781" checksum="186C549E46D30A25" modified="2017-08-30" version="1">MSEKVRELVDIPQQFVKEGTLFVNRCTKPTRAEYIQLCKAVAIGFAVMGFIGFFVKLIHIPINNILVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BCW8</accession>
    <name>A0A1Y2BCW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="10">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BNA4</name>
        <name evidence="14" type="ORF">BCR39DRAFT_524016</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="10"/>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BCW8"/>
    <dbReference type="STRING" id="71784.A0A1Y2BCW8"/>
    <dbReference type="InParanoid" id="A0A1Y2BCW8"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0274">FAD</keyword>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 10 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="191"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORY32327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="518" mass="57357" checksum="A441F23DE9DDBAF1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDG2</accession>
    <name>A0A1Y2BDG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_586781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDG2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BDG2"/>
    <dbReference type="InParanoid" id="A0A1Y2BDG2"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="356" mass="41233" checksum="9466F60574E59414" modified="2017-08-30" version="1">MSDNDNDSINKWRARREQDEKNRVAEEARQRQVAEGGEDFRTGTTDSQDSEEGEYFVYDGRTYNNTSWAYRFPADQEEVIRLDRQHYILSAILPGLYRGPVEEVLANDPTKNRRLLDIGCGTGIWLAEMAERFPHVDCVGIDIMNIQHDHHLENCTYMNVEAPRRLHMFPDRSFDVIQVRQMLSSIYHYPELLKECYRLLRPGGLMLVHEPAGQYYSAWEGYEVSDLAPALHSWIEIFRNSFEYRGIRLDQFNHITDFLMGAGFDRTRINVDVQHRAVCQEDQSTVLAQNEIAHALSFVHASRLMILESGQLTTSQFDQLREDAYNELHLQGRGPAGPLGASGIVSPWCYWWVRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDK9</accession>
    <name>A0A1Y2BDK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_464507</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000009">
        <property type="protein sequence ID" value="ORY32577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDK9"/>
    <dbReference type="FunCoup" id="A0A1Y2BDK9">
        <property type="interactions" value="785"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDK9"/>
    <dbReference type="InParanoid" id="A0A1Y2BDK9"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="15">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="176"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="270"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="580"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="693"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY32577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="852" mass="94348" checksum="51A5E3F6FCD0D371" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE19</accession>
    <name>A0A1Y2BE19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_521573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE19"/>
    <dbReference type="InParanoid" id="A0A1Y2BE19"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY32790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="65" mass="6632" checksum="D1CC7B9EAAD1EDA7" modified="2017-08-30" version="1">MIIGGATQAIIFPLSQCVVPDGIDGPVHLFITNSSTPLSTNIVGQDTSSIIAGQLSFESGNIISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE20</accession>
    <name>A0A1Y2BE20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BCR39DRAFT_520726</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE20"/>
    <dbReference type="FunCoup" id="A0A1Y2BE20">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BE20"/>
    <dbReference type="InParanoid" id="A0A1Y2BE20"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="187"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORY33014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="349" mass="38236" checksum="99818892B74A5198" modified="2017-08-30" version="1">MDVEKLSGLVKDLNEANTANKTDDVLDLLARLKNEVKPTEDLLRQSKAGLAIGKLRKHADTRIASRASEVVKVWKEVIDESKGKRKREEGDVKDEVGKRVKVEAGPSTSASPSAASPSIKSESKPRIKSESKPDPDATPTPAPETPLDEAPPKTLTTIDMARKTPRTHKTDGYTAQLKAEENDGEDVRDKSVQVFYDALAGDSTADKRLLGKKAAGIERAVWKSFNFSTGNDYRAKVRSLFLNLKEKTNPGLRDAIVTSQDGFAPEDIAVMSKEAMASDAIKAMNQALAEENLFKAKAVGETTAETDAFKCGKCGARKTTYYQMQTRSADEPMTTFVTCTNCKNRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF08</accession>
    <name>A0A1Y2BF08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_519895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF08"/>
    <dbReference type="STRING" id="71784.A0A1Y2BF08"/>
    <dbReference type="InParanoid" id="A0A1Y2BF08"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="392" mass="44135" checksum="22EA0780B693AB85" modified="2017-08-30" version="1">MASHVRIATRGMRTGGRRVPFPGLGGAPAIGSSTTSIPPSVSTHPSQSVHVPELSAGFIPRRGKRHATPPAPPAELRDWTLTGEPIAHRPPRTIPVTLPSGYPEPPTYPPSSDYLDTVRDRRSKPHPLWQFFHIPKDARENPPDATQTMPRMGDSLDMEDAENESGRPWLTSELQAKSFADLHVLWYVLLKERNVLETQKLERRRLFIAEQYNGELISPRLRKVRISMSRIKYVLNTRRLGLLAATGPHWDKVERQLAEQSEKETVAALQEGRPLPKPIRVTTLPKWSDPRGTQLANRVPLEERPDAEKIKWRAELLARNFNLERREEESTEEAEEAEEIEGEVSQVEGAVAKNVNQEEVEARDEGFGGGREAKEFVEGVQVDQDGKVKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF22</accession>
    <name>A0A1Y2BF22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_504038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BF22"/>
    <dbReference type="InParanoid" id="A0A1Y2BF22"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="201" mass="21054" checksum="16A3944361D5A8C2" modified="2017-08-30" version="1">MAEGSSTRESGPTWGPFGQEPSDSSTANYWTNAEDKVNITPSLPSIEIHPPVPDPVQCHGSIGFHSSQRGRRGRRAAPPVSGSRYSPYGCHGQKRPQSRVGAGSTSSLPPSKPGDVDTTLAKYLQQMSMGGPSSDEAAQMNTDVEMGGTVPGGSSSTLPTRTSLPRKTESPLCASRESNTDATGGQGPSELDCEENASFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFC9</accession>
    <name>A0A1Y2BFC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_520675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFC9"/>
    <dbReference type="InParanoid" id="A0A1Y2BFC9"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY33522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="549" mass="60145" checksum="7E12D99B31D89D80" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFT0</accession>
    <name>A0A1Y2BFT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_518575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFT0"/>
    <dbReference type="STRING" id="71784.A0A1Y2BFT0"/>
    <dbReference type="InParanoid" id="A0A1Y2BFT0"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="270" mass="28207" checksum="7B30B3673FE260E4" modified="2017-08-30" version="1">MHLHLKGKKALVTGSSKGIGEAIARKLASEEAIVIVHGRDRSQAERVANDIVAQGGRAHVVIGDLTQDDEVESLVKQAEALVGTIDILVNNAGGSGGTVETWTTAQAATWASAFDRNVIAAVRITTRLLPNMQEAKWGRVINISSLAATMTPPTRADYSAAKAAMNAMTASMAKAVAADGVTVNAVSPGTIRSEVLDGAFRQAATQHGLEKDAPWEEIERVALPLFAQVPLGRVGTLDELADAITFLASPLAGYITGVNLRIDGGLSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BG04</accession>
    <name>A0A1Y2BG04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_557105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BG04"/>
    <dbReference type="InParanoid" id="A0A1Y2BG04"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="202" mass="22317" checksum="6F85267A3751C64B" modified="2017-08-30" version="1">MSYQQLTPFLGGIISLLSQIMIFMRYYYRDTCCSPTNLKQTCYCFSSCCDIEKTSAGGKSWDSDSDSDSDSDSGSLRKRGHEDLQWMAKEIAKNNFDWTMFCTVVFAGIDAAVILVWMDDTSADEEIGGKMIWAIYAFGLAWLVARLLYRADPGQLTRRIEDAKTSVSGAVGVAKVGARRVGQGSKTAVINGKRIVTGKPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGE6</accession>
    <name>A0A1Y2BGE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_268035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGE6"/>
    <dbReference type="STRING" id="71784.A0A1Y2BGE6"/>
    <dbReference type="InParanoid" id="A0A1Y2BGE6"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013299499" evidence="3">
        <location>
            <begin position="18"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="299" mass="31217" checksum="DD0AAF4531F1443B" modified="2017-08-30" version="1">MLLSALLPLLAIPSTLAFVDKAVHERMRSRSRTHIQKRSFSGRATFYDVGLGACGGYNVASDWIVAENSDQYGGGYPGPNCGRSITISYNGKTAVATIQDECPTCDYGGLDMSRGLFDHFASEDLGEFQMTWWYNDDNSSPTTTTQQPTSTYVAPTSTYTPPTSTYTPPTSTYVAPTSTYTPPTSTYTPPTSTYVAPTTTSSTVIPTSTTSSLMSSTTASLSASITSSTTASFLPDAVISTSADGSNATATATGTDSASDPESTSTTDSDANPALGNLVMFNQAVAYLGHIVVVGAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGQ9</accession>
    <name>A0A1Y2BGQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_597012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGQ9"/>
    <dbReference type="InParanoid" id="A0A1Y2BGQ9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="302" mass="32875" checksum="B98C6EB581219F2C" modified="2017-08-30" version="1">MDPGQSSNPPPGDCSPSTSTNESRMEGPIVLPSFKELITSLPPSSLYSQGPGTCSQMPPSSSPPERSPRDSRKQGSSKSSYSGYSDQEAGWPISQLGVEGTDTSSQQHFHQPTGQTSPSTGLREQQSTFGNISDVMTTASHPGNRKRWTVKTPCTSCFHEPGSSCSGSTIREDRLHPPRQDIQGWRGDSSSRLTTTRLRIMPGAWQILHSHVSCDQQISIVSRPENELSQHKPFLELGFTVLSNAYFPAQVSRPTTGTQTSPADWQSPSLDSKAWTICEVVMLKMHEEIGKIYGTLGPLKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGX1</accession>
    <name>A0A1Y2BGX1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_517997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY33976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGX1"/>
    <dbReference type="InParanoid" id="A0A1Y2BGX1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="57" mass="6219" checksum="1B3EBC1ECC54D471" modified="2017-08-30" version="1">MQYDLLPLPMYLAVGSSVTCSLASLFLFENSLERKFFLSGLDLLCLDAETTGTQAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BGZ7</accession>
    <name>A0A1Y2BGZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_235137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BGZ7"/>
    <dbReference type="InParanoid" id="A0A1Y2BGZ7"/>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="114" mass="12286" checksum="3A342844EA0C4247" modified="2017-08-30" version="1">MSITAPVLDKSDPKSDRLYAFHLPSSPEWEEQKDWFGQSAMMGAGAGMFIKNPLFVWGSMIMGVIGLVNYQPLRAPKDSTSPLITLGMAFAGVATLCLPKMMLAPEAPISSPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHB1</accession>
    <name>A0A1Y2BHB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BCR39DRAFT_520440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
        <property type="protein sequence ID" value="ORY33495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHB1"/>
    <dbReference type="FunCoup" id="A0A1Y2BHB1">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHB1"/>
    <dbReference type="InParanoid" id="A0A1Y2BHB1"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="425"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="121"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="249"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="501"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORY33495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="676" mass="76128" checksum="90B8FF2541B25F50" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHI2</accession>
    <name>A0A1Y2BHI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BCR39DRAFT_518265</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="MCFC01000004">
        <property type="protein sequence ID" value="ORY34050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHI2"/>
    <dbReference type="FunCoup" id="A0A1Y2BHI2">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHI2"/>
    <dbReference type="InParanoid" id="A0A1Y2BHI2"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="9"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="533"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORY34050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="760" mass="82661" checksum="56877CCCBAC5227C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHI5</accession>
    <name>A0A1Y2BHI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_517132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BHI5"/>
    <dbReference type="InParanoid" id="A0A1Y2BHI5"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="417"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="417"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="731"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="824"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="619"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="930" mass="101418" checksum="E222D3820978BE8B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHJ4</accession>
    <name>A0A1Y2BHJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_517272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHJ4"/>
    <dbReference type="FunCoup" id="A0A1Y2BHJ4">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHJ4"/>
    <dbReference type="InParanoid" id="A0A1Y2BHJ4"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="282"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="326"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="404"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="605" mass="66919" checksum="D97FAFAFCECC642D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BHS2</accession>
    <name>A0A1Y2BHS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_517702</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Also forms a small population of homotetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BHS2"/>
    <dbReference type="FunCoup" id="A0A1Y2BHS2">
        <property type="interactions" value="880"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BHS2"/>
    <dbReference type="InParanoid" id="A0A1Y2BHS2"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="211"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY34326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="544" mass="59779" checksum="0FDA23D6812A82A4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BI04</accession>
    <name>A0A1Y2BI04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_188949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BI04"/>
    <dbReference type="STRING" id="71784.A0A1Y2BI04"/>
    <dbReference type="InParanoid" id="A0A1Y2BI04"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="534"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
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        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="901" mass="96737" checksum="CAF89466530D703A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BID2</accession>
    <name>A0A1Y2BID2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_513301</name>
    </gene>
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        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="MCFC01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y2BID2">
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    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BID2"/>
    <dbReference type="InParanoid" id="A0A1Y2BID2"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY34552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="197" mass="22431" checksum="5A298BD6FFDBC8DB" modified="2017-08-30" version="1">MVYWIFGYGSLIWKPPPHAVEQRSGYVKSVVRRFAQSSIDHRGTPEQPGRVVTVIEASDWVQLSGAESVSEGDDYVWGVAYRIEEAFSEEVRAYMEHREQNGYTSHEVTVYTIENGEEIPVVHGATIWIGRLDNPAFVGLEPLSDLANKIHKRIGPSGPNKDYLYKLAESVRTLYPHVRDDYLFELETAVRRLDSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BIL5</accession>
    <name>A0A1Y2BIL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_513805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BIL5"/>
    <dbReference type="STRING" id="71784.A0A1Y2BIL5"/>
    <dbReference type="InParanoid" id="A0A1Y2BIL5"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
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        <location>
            <begin position="344"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="731" mass="77424" checksum="9F9710F2D00358DD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ20</accession>
    <name>A0A1Y2BJ20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XAP-5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_461854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ20"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ20"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
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        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="179"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY34784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="317" mass="37405" checksum="BE1C115645163045" modified="2017-08-30" version="1">MSERIPEASQRQLMIVKQREREAAEHQRQKEALIRDSQKDHTGDRFIGISENIDDRLKKSTIGLVTLSDFQRTRNDLEEEQRQLLAKTLADKEIASTKVKKTKKKQKLKLSFVGDEEEVIEPKRKRTDSEEASEKKRFAKNPDVDTSFLPDREREEQERVEREELRKAWLAQQERIKQEDVEITYSFWDGSGHRKTVECKKGDNIAAFLSKCRAQFPELRGTSVENLMYIKEDLIIPHHYTFYDFIINKARGKSGPLFNFDVHDDVRMMADATKEKDESHAGKVVERSWYNRFKHIFPASRWEIYDPDKDYGTYVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ36</accession>
    <name>A0A1Y2BJ36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UAA transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_461822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJ36"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ36"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="437" mass="47923" checksum="C2E76C727016EBE6" modified="2017-08-30" version="1">MTDRSLLKAFVESTAGEWVLILSLVFGGCCSNVWALEAILKDHPKSGTFLTFAQFVYVAAQNLSHQFYLPPRSTGNDKGWRLPRWRKNQVPIRRWMVQVLLFLGVSLMNNYAFGLKIPVTLHIIFRSGGLCISMLTGYLMAGKRYSIGQVFAGIIITTGIVVATLSAPRRRSPRPTTASVTATSSEEWLSESAQFVSGIALLSIALFMSAWLGLWQEQTYKKYGKQWREALFYSHVLSLPFFIPLHSDLSNTYRSLAASPGLTLFAIPQPSPMALFSLGEIGNSAGKTLLQWKHVVVPSALFAVALDVITQGVCIRGVNRLTSKVNSTTVNLILTLRKAMSLTISVWYYGSGFSVGLAVGGAMVLSELQNVPQNSSSCKAVGTIIYSAAPWPIDKDLIRKHEDAPSLGEKLSRGRSSAVEDSVPGTSQRHSTRSRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJ70</accession>
    <name>A0A1Y2BJ70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_585787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJ70"/>
    <dbReference type="InParanoid" id="A0A1Y2BJ70"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY34841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="311" mass="34690" checksum="A71F71C86BD36BEF" modified="2017-08-30" version="1">MATGALSTTAVGTAYELHCLRYLNNRLQMSLVRCGGSGDEGIDLKGGWWIPSQAFRGYKAPIKKAAGHRIFQSNDVQEFQEEIRKEDKELDRKEINGAKRIRVFGQCKAQKNALSSRQVREMEGVLAHHYGQAVSRGPHQFTSKGRPRPHTPPRALGLILSQSGFSQMALIRAWKSPAPLMLIHLSGGRPLAERSPSAVEPDHHPTLEAARNVLVLNDLNNKNGNINTNREKERNESFELDSQGEGDQERIPVVGAWWNKQVIGTRGIFKDGLELRRIMFGNGKDAEGTYQVWWNGKPLPRSGPSVDIEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJB7</accession>
    <name>A0A1Y2BJB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_516794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000003">
        <property type="protein sequence ID" value="ORY34215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJB7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJB7"/>
    <dbReference type="InParanoid" id="A0A1Y2BJB7"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="4">
        <location>
            <begin position="310"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY34215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="663" mass="75224" checksum="8369C9C86559D15B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJK2</accession>
    <name>A0A1Y2BJK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_515747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJK2"/>
    <dbReference type="STRING" id="71784.A0A1Y2BJK2"/>
    <dbReference type="InParanoid" id="A0A1Y2BJK2"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="217"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="319"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="431"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="580" mass="63667" checksum="8FD279D4A8AFFD2B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BJM6</accession>
    <name>A0A1Y2BJM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative importin beta-2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_462095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY34979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BJM6"/>
    <dbReference type="FunCoup" id="A0A1Y2BJM6">
        <property type="interactions" value="893"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BJM6"/>
    <dbReference type="InParanoid" id="A0A1Y2BJM6"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000402">
        <property type="entry name" value="Related to importin beta-2 subunit (Transportin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY34979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="922" mass="101761" checksum="C840A2D466374E49" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BKD9</accession>
    <name>A0A1Y2BKD9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_596900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000002">
        <property type="protein sequence ID" value="ORY35090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BKD9"/>
    <dbReference type="STRING" id="71784.A0A1Y2BKD9"/>
    <dbReference type="InParanoid" id="A0A1Y2BKD9"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="489" mass="52580" checksum="ACB6C5E6342C7B23" modified="2017-08-30" version="1">MSPKPTADYGSIGPANPVEEPSSLTNDADLENAHLLSEPTDGNGVVRETPPFREIAFLCFGLWMSMFTSAVSATVITNLQLTIGSYFEAGDLVSWLGSGYLLGLAGLTPLYGKVAEIMGRRQAMIVAFVLFAAGTCLCAVASSMRFLIFARIVAGCGGGGLLTLTAVVISDTVSIKDRGIYQGYVNLVWATGSALGALVGGWVADRWGWRWAFWMQIPPLILAFALIVWKVHPPKREHDQSLRERLGRIDWLGFVVLLISITTLMISCSLYTYSLPAKNPLVPPLFIAFLTSLPLLYLVERKWAKEPIIPIDLIEQPTPALILVSTMLLSMNVFARFFMCPIYIHVVKGFGGKDTGLLLLPSSLTLAMGAVFGGYIHRIWAELAIAAFAGGIIITNVLTALVASVPHSEMAVATSVLYLGRAIGQVLGASLSAGLQQLVLSAQVRLRFPDDPELAGAIIKAPEQTIPNLSDDNKLQALLAYLASLKSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BL90</accession>
    <name>A0A1Y2BL90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_6770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BL90"/>
    <dbReference type="InParanoid" id="A0A1Y2BL90"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="112" mass="12988" checksum="9E6A0D677AD6BD0B" modified="2017-08-30" version="1">MSHWLSLCVLIIYITYHSRVQFKRQKTETLTNFKLPTYLSFRTRSISHSMYFISLIAFFLSCFSFSFPTFLCLSSLTPSSHPLFLVFLSCHVPVLFCLKNDLNASVLDSLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLA4</accession>
    <name>A0A1Y2BLA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_19454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLA4"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLA4"/>
    <dbReference type="InParanoid" id="A0A1Y2BLA4"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="166" mass="18038" checksum="8A1A571F724AA2DD" modified="2017-08-30" version="1">MSYDPFSDNNRTQRTRFVSPSPIPSPSPSPTPSLAQPEYPPQSYTNINYEDGSGDVGYGGPAGGVDINGQHVPWSGGDEDEETKPLTSGSPTPFLASDPYGRPPSVLSSGSGADFIRRQTIPKRGATTRRVKLTNEGNWVNEYPVPRPILTAVEPKWLSDKSTEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLG6</accession>
    <name>A0A1Y2BLG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_555765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLG6"/>
    <dbReference type="InParanoid" id="A0A1Y2BLG6"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="431" mass="45368" checksum="5DB7CB171E25CC40" modified="2017-08-30" version="1">MSTNRLTPNSLSSRYDDRILNEDNSGEDGSQTSWSHGSSLARHSQQRYVSSSQTVANTHNQAITPSGSVSITRSTGASSETDAHQQNDSIPGRVVWIPPKATIFSQTVRRLNTPSKSASMKQNAGVHPKSHARARSVSTPAPTDLPLGPTRCFSNASANLQDQVSPSQNFRSTKDASDSIVTPRRVFTYSQTVALPPAESRAHGTSALPHKLPRTSTFSEGVTSHTPAGNSSKSSPNEKNVSTLSTPIRPQIATASTSSNSVPSLRSSINVPNTVPVTRRSVSSLANRAPKVEKSSSSPKTFPPQSPASTSGVLSSSSIGPNSRNPSDSSNDGRNIITFSETIRPPRPQAIVRSNSVSSPLKTSVPYCEGARVPSSEIGSGSPFHQNVARVGSPLDGARESPVSEAADDETPPGSRPDSACSGKTLVNPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLP3</accession>
    <name>A0A1Y2BLP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Single hybrid motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_511548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLP3"/>
    <dbReference type="STRING" id="71784.A0A1Y2BLP3"/>
    <dbReference type="InParanoid" id="A0A1Y2BLP3"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY35696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33130" checksum="0A4D7709534F19C8" modified="2017-08-30" version="1">MATTAMRMPAMSPTMTEGGIAGWKKAEGESFAAGDVLLEVETDKATIDVEAADDGVMGKIIVQDGASKIPVGQVIALLAEEGDDLSAIEIPKDLSPPTEDQPPPRKDESSATTQNTQAAPEPKKEESPVEHKDAGHKEIKHPQPLFPSVSRLLLESDLSSEEIYKLKGSGLHGMLTKGDVLKAMGKIQNVWGSAEKLNLDILGPSGRRQSESAATTPTEPAKQVKEEPLDGPALRRLILAGMSKATEPAKPIVPHTTSPLPLSPDAEFDSILSPYSTLLPSPQPSVSIPGPDALKAMEGKGPSTKKDEWAGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLR4</accession>
    <name>A0A1Y2BLR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_29422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLR4"/>
    <dbReference type="InParanoid" id="A0A1Y2BLR4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="99" mass="11341" checksum="6F981F59819AC250" modified="2017-08-30" version="1">MYWAVLGMILYLVRLYRVMAMCISCHLANIGLLSRYVHYLTFSPGTLTSYGFYSMLDVTASTDANYLSTVFLVLPCSSPPLFLLLHHLYFLHHLLSPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BLT4</accession>
    <name>A0A1Y2BLT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_511732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BLT4"/>
    <dbReference type="InParanoid" id="A0A1Y2BLT4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY35719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="195" mass="20862" checksum="1BE18EBF6C10FDCC" modified="2017-08-30" version="1">MTPLVFAQSAAFDELLFILVALFKRHAVNCHIQVQTNGSPTLRVTPRDGRARQFIKHLWKDCNNWIRNSNDQQIRQDLDLGMEGVLRVKRHLSPISKSSVSALKNFWTNYTPVAIGLGSGAAAGAGVKVCAVAAKGSAVAKGATALKVVVAVAAVPTLPVLAVGAAVGAAVGGWWMWTSAEPDKTVARHSRESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BM52</accession>
    <name>A0A1Y2BM52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_511402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000001">
        <property type="protein sequence ID" value="ORY35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BM52"/>
    <dbReference type="STRING" id="71784.A0A1Y2BM52"/>
    <dbReference type="InParanoid" id="A0A1Y2BM52"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07130">
        <property type="entry name" value="ALDH_F7_AASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521:SF1">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="53"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="545" mass="57928" checksum="549B6BBF82C8CD55" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ADR5</accession>
    <name>A0A1Y2ADR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">BCR39DRAFT_82850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000130">
        <property type="protein sequence ID" value="ORY20604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ADR5"/>
    <dbReference type="FunCoup" id="A0A1Y2ADR5">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ADR5"/>
    <dbReference type="InParanoid" id="A0A1Y2ADR5"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000576">
        <property type="entry name" value="Ribosome biogenesis protein ERB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="224"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="752"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="814"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY20604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="840" mass="93791" checksum="B7CA27BE5FE2EA29" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AE53</accession>
    <name>A0A1Y2AE53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_474895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000126">
        <property type="protein sequence ID" value="ORY20754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AE53"/>
    <dbReference type="FunCoup" id="A0A1Y2AE53">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AE53"/>
    <dbReference type="InParanoid" id="A0A1Y2AE53"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="93"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY20754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="302" mass="32676" checksum="91854C6468E88628" modified="2017-08-30" version="1">MNEYEDGHGHGHGHEHHLLGHDHDLHSHDDGFTMHTHASVESMGGTWTPDEHGHTHEHLEHAACADLLSLIGKFSERDMPDYTGRDWTERAFTIGIGGPVGSGKTALLLALCRALRDSHNIAAVTNDIFTREDQEFLIRNEALPTERIRAIETGGCPHAAIREDISANLGALEELQASFGCELLFVESGGDNLAANYSRELADYIIYVIDVSGGDKIPRKGGPGISQSDLLIVNKIDLAPYVGASLDVMRRDAAKMRDNGPTLFTSVRNNDGVSDVIEAILGAWRVSGAAGRFSKGKGKTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEI9</accession>
    <name>A0A1Y2AEI9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BCR39DRAFT_74549</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">68-887.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000122">
        <property type="protein sequence ID" value="ORY20906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEI9"/>
    <dbReference type="FunCoup" id="A0A1Y2AEI9">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AEI9"/>
    <dbReference type="InParanoid" id="A0A1Y2AEI9"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007654">
        <property type="entry name" value="NAD-dep_histone_deAcase_SIR2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04574">
        <property type="entry name" value="DUF592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="17">
        <location>
            <begin position="126"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORY20906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="536" mass="59898" checksum="06FAB5A604038DE3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AEY7</accession>
    <name>A0A1Y2AEY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal protein S5 domain 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_554783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000124">
        <property type="protein sequence ID" value="ORY20837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AEY7"/>
    <dbReference type="FunCoup" id="A0A1Y2AEY7">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AEY7"/>
    <dbReference type="InParanoid" id="A0A1Y2AEY7"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="42"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY20837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="265" mass="27432" checksum="8FA1E55650AFA1DB" modified="2017-08-30" version="1">MAGVFDRRRIPAPESSFPPIFEPSDEPEAGPSKRAGRSNDHIQDIFLQTGLVTQANGSAYIEQGGVKIACSVYGPRPKQPPYSSTGTLNLEVKFAPFASHSRRAPLRDTEPLPLSALISQSLLPAIQLHLLPKSSLDIHLLILESSTTAAVLSAGLTVASAAVADAGISMNGLGVGGTALRVGKETLLDPSAGEEASGNGLVCLGSLPAQGKVTGVWISGELEVEELCDLIDKAGEAGEQAHTTVAHTLLEEAEARGVGLGVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGD3</accession>
    <name>A0A1Y2AGD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_562598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000107">
        <property type="protein sequence ID" value="ORY21653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGD3"/>
    <dbReference type="InParanoid" id="A0A1Y2AGD3"/>
    <dbReference type="OrthoDB" id="2283025at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY21653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="214" mass="24874" checksum="F0BDF26DE3E4B74D" modified="2017-08-30" version="1">MYTPKRRQDLSADRDHLRSHRLTNDKEKAELLEAEKDVFESQILELNDKITELKSEAMSKSEAFTSVLQSYEELKAQNHQLEESHKAFEEELQVLRRSLDKQADLHRDLVNTWKIKLESSQKLTAEVENARTKLVEKLDDLKATSYETKMNWESRLKLAEDKAIQRGKRLLTSLPELPLWKELLKESTSPADMAEIGMEFINFGVQGCNERALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AGR1</accession>
    <name>A0A1Y2AGR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_50414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000104">
        <property type="protein sequence ID" value="ORY21798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AGR1"/>
    <dbReference type="InParanoid" id="A0A1Y2AGR1"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="58"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY21798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="444" mass="49865" checksum="ED5D855A04AE3500" modified="2017-08-30" version="1">MVYHLSSHASRSRHADRSPSPTQSLSSSAVLPPSVVSTGTIRPSNLPSALGGFKDLSTNLPIFASCRFFLAEETWRSHFYLRITNAVETYCGTILNPYDVQNGTDYLLVPNLFEERTHGVGSRLHHGLEPYQHLVKLVRVSTDWLYRCIQYETVFEPDHGDSLLILGTVSVELDEKSRNTGGTMSRHPKYDKVKEKDKDRVNEILQIMETYAWEDDSATRKRFYDYCDNMSPDSAKLCSTKSFVGKYMQVFEEMHLAFAETRRLKARGEGKHNRSTRTRKSQTKQHSPSTSTIRSRSLLDSVSTHNDLSSVTSSMERSPFSEISAPSPIPTMGFIPTSTPVNDISQNEEPEQSLSIGSSRVNQKKRAFDEVDHNDEDDDARDKDIGGTFPESEPLNSRQQVSHFIANVTAKLLSPGLIHAGIIGSVVKFTQTIRRTSSTYGKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AH81</accession>
    <name>A0A1Y2AH81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_48553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000101">
        <property type="protein sequence ID" value="ORY21948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AH81"/>
    <dbReference type="InParanoid" id="A0A1Y2AH81"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY21948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="254" mass="28157" checksum="4E1366E20AB4C52D" modified="2017-08-30" version="1">MDQHNASNVPRPRQSCTPDNFHATISAYESFALHVKRANSLTRQYDETLTSYAAPNVLYYTCGLYQAELRKGLIGEMASATERDLARRAYGLCVGEPGSRPLISIPESLWSSEPLQERKTAVKIANWLARQFADSQGTSVVVETILRETERTKVSVSDGRSKHEPGKHCKQQADADCTTSFCRSLHYSAPLLSSFTTPFLRPLVFSSIRSCMGSETLHRAQLQVSMRSQVSMRTQATNPSITSTIVKSSASETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ17</accession>
    <name>A0A1Y2AJ17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_551262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ17"/>
    <dbReference type="STRING" id="71784.A0A1Y2AJ17"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ17"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="512" mass="56497" checksum="5C00D18C61A77F72" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ82</accession>
    <name>A0A1Y2AJ82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_501443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000090">
        <property type="protein sequence ID" value="ORY22629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ82"/>
    <dbReference type="FunCoup" id="A0A1Y2AJ82">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AJ82"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ82"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY22629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="141" mass="15994" checksum="D8834040CC07D680" modified="2017-08-30" version="1">MVSEIRLRLARHGLRNSSVYHLVAISNKKARNAAPIEKLGEFNPRPRVQSLSELPPAAQVFGRESWVVPKEKRIEWNVDRIKYWISVGATPTKSVVRLLERGGILQHPHKWQHRWTPGRPPIALEGTVKSPSAAAEQTESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AJ95</accession>
    <name>A0A1Y2AJ95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_591257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000091">
        <property type="protein sequence ID" value="ORY22562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AJ95"/>
    <dbReference type="InParanoid" id="A0A1Y2AJ95"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY22562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="197" mass="22378" checksum="F4B9F5B56001D99B" modified="2017-08-30" version="1">MSRAPSNNNSFRRSTRHTSGGSAIRSSHGYTDNRSRVQPTDNSSQASTDVTNTQNASTDRTYVGVSIFTSPQRTTGDSTFRPPMTTSSIARYRERIGTVVETLRRWSVSQDHSRQIPVDDVVIRAQSLYTELQQFRLPPNVEDFTIGEAYESRITEIEEQVHQYVTTRSYESEPSQQLQSGEGDRRESPEEMFPMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AK76</accession>
    <name>A0A1Y2AK76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aspartate/glutamate/uridylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_551081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000089">
        <property type="protein sequence ID" value="ORY22700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AK76"/>
    <dbReference type="FunCoup" id="A0A1Y2AK76">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AK76"/>
    <dbReference type="InParanoid" id="A0A1Y2AK76"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000041">
        <property type="entry name" value="Glutamate 5-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000045">
        <property type="entry name" value="Glutamate 5-kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY22700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="546" mass="58990" checksum="DCE2C503DE4A958C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AKK4</accession>
    <name>A0A1Y2AKK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_591213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000088">
        <property type="protein sequence ID" value="ORY22767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AKK4"/>
    <dbReference type="InParanoid" id="A0A1Y2AKK4"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1591"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1364"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1714"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1752"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1853"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1424"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1445"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1461"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1513"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1911"/>
            <end position="1921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY22767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1928" mass="212210" checksum="852D27510765925C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALH5</accession>
    <name>A0A1Y2ALH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_550008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000083">
        <property type="protein sequence ID" value="ORY23140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALH5"/>
    <dbReference type="STRING" id="71784.A0A1Y2ALH5"/>
    <dbReference type="InParanoid" id="A0A1Y2ALH5"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY23140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="644" mass="71809" checksum="1841D2FE0084B562" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ALR4</accession>
    <name>A0A1Y2ALR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_507980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000086">
        <property type="protein sequence ID" value="ORY22895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ALR4"/>
    <dbReference type="InParanoid" id="A0A1Y2ALR4"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY22895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="156" mass="17279" checksum="BC69BCE1A6FC3FA3" modified="2017-08-30" version="1">MDPTKAKAWELWTNDLIGTDLSETLGASHPRDYSRRLFFIEEGSYTKVRVSAGQGLLIPGDSVHAVKTTKPAMISMANFGPGRMRETERRGRTFGTMLLVSVSHSLTNRTVTLALFEVETRRGHPVMAVPTAFYPHSQGSVRSLLAFILTELIPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM21</accession>
    <name>A0A1Y2AM21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_549120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000078">
        <property type="protein sequence ID" value="ORY23546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM21"/>
    <dbReference type="FunCoup" id="A0A1Y2AM21">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AM21"/>
    <dbReference type="InParanoid" id="A0A1Y2AM21"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000469">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY23546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="114" mass="13072" checksum="354244988647B685" modified="2017-08-30" version="1">MKFTITSYNAVATWKWDTSSEPHKLWRYAQPDAEGSYGDVEDDEDEDDDVCGICRLAFESCCPECKVPGDDCPLIWGECTHVFHMHCLLKWIGTESSKQQCPMDRREWGKSPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AM80</accession>
    <name>A0A1Y2AM80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FMN-binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_548865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000077">
        <property type="protein sequence ID" value="ORY23606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AM80"/>
    <dbReference type="InParanoid" id="A0A1Y2AM80"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY23606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="261" mass="29182" checksum="4274A76F7C5A1693" modified="2017-08-30" version="1">MYIRPVHAELDPPTLHAFVRTYPLGLFTTYCPHPTISSLQSTHIPFVLDTPTDGPTILRGHIARANPHCKALLAASELPEEVVVIFQAPVHSYVTPKFYTTTKPLNGRVVPTWNYAAVQVYGTLRLHHTGKEGADFLQSQIEALTDQQELKAGHEKPWKVKDAPDKYVDLLKKGIIGLEIQVSRIEGRFKMSQEMADGDWNGVVQGFKGLGTKEGDEMARFIQERGKDREGGSRKEKEESEAVQRSLAEEREAVEQEPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AMH1</accession>
    <name>A0A1Y2AMH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_548802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000076">
        <property type="protein sequence ID" value="ORY23696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AMH1"/>
    <dbReference type="FunCoup" id="A0A1Y2AMH1">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AMH1"/>
    <dbReference type="InParanoid" id="A0A1Y2AMH1"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY23696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="358" mass="37436" checksum="64295B02EDB73DAA" modified="2017-08-30" version="1">MPPAAAKTIFVANIPYDVSEEQLAGVFAEAGPVSNVEIKFDPATGRSKGYAFVQFYDEATAASAVRNLQEVPVNGRNLRVELSTDEPGPRTRGGRGGGGGRPSGGRKDETPPFRGTPSGSVPPPGAYGADDIRVDMSLLPPGVDPLPGQKSTDAISKTLAGINPGQMQEVMNSMKTLIASNPAQARAMLHEMPQLAYALFQAMLLMNIVDPSVLQRIQPLPPAHVPAPTPAYPPAGPPQAAFPPFPPQAQQAPPPSYPPYAGASSTPPYRPPPPPAQQGYGAPPPAQSYQPPQGYGAPPPQPAAGLPPNVQAALSGLPEDQRTMLVQVLSLTPEQISALDVGQQASIRQLRQQFLGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ANB9</accession>
    <name>A0A1Y2ANB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_548007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ANB9"/>
    <dbReference type="FunCoup" id="A0A1Y2ANB9">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ANB9"/>
    <dbReference type="InParanoid" id="A0A1Y2ANB9"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="151"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY24073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="405" mass="44330" checksum="CC07AAB243AD0241" modified="2017-08-30" version="1">MESTPLVAKMPEAFHRASARFVVGVLFLLCVVLLWTASNFITSRLETGDQGWNKPFLITYLNTSSFALYLLPAVWKFYRSPKHSNEEEYRPLPQDEAPGRRSASTIRSRSRSPITMPLSSLGPPPLPVQPSFEDLPKLTTRETAEVAAWWAVVWFVGNWAVNASLAWTSVASVTILTATSGFFTLGLGRVFGVESFTPLKIFGVLVSFIGVVLVTKSDSTIDTSVLVERPTRPLLGDAAAILSAACYAIYVVLLKKKVVDEERADMRLMLGFAGLFSILFLLPAFPILHFTGWETFQLPPNREAWIICGINMLITLSSDYLYMLAMLKTGPAFVTVGISLTIPLTLTISYFFPDLGPNAITALSLIGAVLVCLSFGAMGWSEWKESDRPRSSAAAGESNVTLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AND9</accession>
    <name>A0A1Y2AND9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_547996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000072">
        <property type="protein sequence ID" value="ORY24071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AND9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AND9"/>
    <dbReference type="InParanoid" id="A0A1Y2AND9"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="64"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY24071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="355" mass="38492" checksum="951C8506045465B2" modified="2017-08-30" version="1">MPTVLITGLNGFVAVHTALKFLSNGWSVRGTVRSQAKADKVKQLPSLLPYIQQGKVEVVIVADLVEGDFSQALDGVDAVAHVASPINLADGTWADYRDPAVKGTVRLLEQAAKVPSVKAVAQMSSWAAAADISVPFTEQIGKVYTENDWFPLTDEDAEKLVDNHDGVTQALWYCTSKKLAELAAHETRKRTGAAYSVGSVLAPMIFGPALHYGPKATGEELNKADASTSWLYQSVAGGRDGTLPPSSFPSWTSVESVAEALYKIIEKRSNERYLIYEGPFDYQQFANIARKLYPELDKAGVIPLGNPEDCPSEKGTYTLDTTKAERELGIKFDHTKEEMIKQVVDQIVALGAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AP85</accession>
    <name>A0A1Y2AP85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_561566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AP85"/>
    <dbReference type="InParanoid" id="A0A1Y2AP85"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY24389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="385" mass="42056" checksum="515340803FF3E4E4" modified="2017-08-30" version="1">MCPYVAPDSESSTPATSITTTPLQSLSRSSSTTIVSTPTPTNTVSRLPSPSTPRLNLDRPLPPVPAGEGPDRPNMQRRPSLLDYIRTPPARITDPEAQATANTSPSPPSVTQRDFGRAGQEEVHDEQQQRQQQSPQQRQLSPPSQQQQPLPLHGWTQGWSLTGRGRNDPPSTASTVATSVTLVSNATETSDTRSESSFGHNADGSAVTPRIQYPTPPPRSQSLPRLLEIHARRENIELVDLQSRSQVVRFAEGDDVMAGHDVDQTPRAFNANEFRVPDIPPFRNPSTLRPGDRSAIYAVPASPLSPDPVTFRVGNEGRIDQSATTPEAGPSRARNLLYPPTRIEDEDSEEAIARASTEAQFSTQLREPRPDLFTRAEQDKCCVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AQA1</accession>
    <name>A0A1Y2AQA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_547130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000068">
        <property type="protein sequence ID" value="ORY24397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AQA1"/>
    <dbReference type="SMR" id="A0A1Y2AQA1"/>
    <dbReference type="FunCoup" id="A0A1Y2AQA1">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AQA1"/>
    <dbReference type="InParanoid" id="A0A1Y2AQA1"/>
    <dbReference type="OrthoDB" id="2585648at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="11">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY24397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="103" mass="11409" checksum="AC5C20A04BCA7598" modified="2017-08-30" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDSVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARB1</accession>
    <name>A0A1Y2ARB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 16">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 16">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BCR39DRAFT_545796</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 16">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 16"/>
    <dbReference type="EMBL" id="MCFC01000064">
        <property type="protein sequence ID" value="ORY24757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ARB1"/>
    <dbReference type="FunCoup" id="A0A1Y2ARB1">
        <property type="interactions" value="609"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2ARB1"/>
    <dbReference type="InParanoid" id="A0A1Y2ARB1"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 16" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 16" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="20">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="20">
        <location>
            <begin position="157"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="19">
        <location>
            <begin position="307"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="661"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="750"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR016308-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORY24757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="801" mass="87992" checksum="F827B967AD1A05E4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ARX0</accession>
    <name>A0A1Y2ARX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_545159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORY25050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="411064at2759"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAA_hydrolase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY25050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="292" mass="31505" checksum="F799C179C90F1208" modified="2017-08-30" version="1">MTIPPTATWKRLIRFIDADGVERLGEPCHPEQDVGLAMRNGEVIEAFVVDSTTPWDQAAVTTGQKVHVTSLLSPITGQQAGTIRCTGLSYTDHAAEMGLALPDVPSVFLKPGQAVNNPNSTVVVPKTCQREEMDWEVELAIVIGKECKDVSESEAMDYVLGYTIANDLTARKHQASSSQWCYAKGFDGFCPLGPVLVSTRSLPDPHIVKLTTDVNGKRKQTGSASLMIFPLKHVISYLSQGSTLSPGTVIITGTPPGIGSGMRPPQWLKDGDEVHCWISDGMGTLVNKIVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AS78</accession>
    <name>A0A1Y2AS78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative U4/U6 small nuclear ribonucleo protein Prp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_544349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000058">
        <property type="protein sequence ID" value="ORY25336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AS78"/>
    <dbReference type="STRING" id="71784.A0A1Y2AS78"/>
    <dbReference type="InParanoid" id="A0A1Y2AS78"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="7"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
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            <end position="102"/>
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            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
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            <begin position="213"/>
            <end position="262"/>
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    </feature>
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            <begin position="263"/>
            <end position="304"/>
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    </feature>
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            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
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        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
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            <begin position="413"/>
            <end position="458"/>
        </location>
    </feature>
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            <begin position="95"/>
            <end position="110"/>
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    </feature>
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        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY25336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="532" mass="58639" checksum="0F212CE03498C864" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASU2</accession>
    <name>A0A1Y2ASU2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_543680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2ASU2"/>
    <dbReference type="InParanoid" id="A0A1Y2ASU2"/>
    <dbReference type="OrthoDB" id="2576332at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY25658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="548" mass="58833" checksum="A498B6945F13B9CA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASV0</accession>
    <name>A0A1Y2ASV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_543955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2ASV0"/>
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    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="567" mass="63333" checksum="E649F76119DE5B93" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2ASW1</accession>
    <name>A0A1Y2ASW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_543591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000055">
        <property type="protein sequence ID" value="ORY25649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2ASW1"/>
    <dbReference type="STRING" id="71784.A0A1Y2ASW1"/>
    <dbReference type="InParanoid" id="A0A1Y2ASW1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="796" mass="88361" checksum="968572510475AFA0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUC9</accession>
    <name>A0A1Y2AUC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_543903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="MCFC01000056">
        <property type="protein sequence ID" value="ORY25535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUC9"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUC9"/>
    <dbReference type="InParanoid" id="A0A1Y2AUC9"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="353"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY25535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="563" mass="63497" checksum="CA3195940522D1C4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AUX3</accession>
    <name>A0A1Y2AUX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_274869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AUX3"/>
    <dbReference type="STRING" id="71784.A0A1Y2AUX3"/>
    <dbReference type="InParanoid" id="A0A1Y2AUX3"/>
    <dbReference type="OrthoDB" id="2576135at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY26080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="202" mass="21513" checksum="85FB229C102F461C" modified="2017-08-30" version="1">MGLGSYTCPVCFCQPERAVMTLCGHILCARCLLDSLLAALKRNPNPYPGQPPSNRGRGTRGRGSRGGGRGGRGGYSNSGTHSHFSSTAGESKLGGPTEWTTETLETAWSKNLEIQYLIINGALPEIARGYTDDDRKAIVPDPGYFHVIEVLKGLWKIEPGGYIVEGECPVCRKPLPGGFAPPDTGFGGVIPLQLRLGGIDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AV42</accession>
    <name>A0A1Y2AV42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_541994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000050">
        <property type="protein sequence ID" value="ORY26150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AV42"/>
    <dbReference type="STRING" id="71784.A0A1Y2AV42"/>
    <dbReference type="InParanoid" id="A0A1Y2AV42"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="92"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY26150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="415" mass="46308" checksum="EFA7C88470B4DB19" modified="2017-08-30" version="1">MQRWRLSRFLSSASLQGLRLSSMSFGRVIITKLKAPYQHTFVRSYYRQTSISASTTPPCLSLQRSISLSRTFATTSGNTQKMRCILIKDGKGPVENLYLGEEQTPEPKEGEVQIKIKNFGLNRMDLLQREGKYPLPPKASKTIMGVEFSGIVTKLGESVKQYKEGDEVFGLAYGGAYAEYIVSPEEMLLHKPKEISWIEAAGFPENWMTAYQALFLEGGMKKGSNVLIHAGASGVGSAAIQLALHVGGAAKVFTTCGSDEKVKFLEELGGTDKLHVFNYKTQNFEEEIKKIDEGVDLIIEFIGRNYFVSNLNLLKRDGTMVYLGMMSGSKLDAGVDLLSVIYKRLTLKGSTLRSRTVDYQAKLLKHFEEDALPLIKEGKMKVEVHEVFPWTKVAEAHKEMEANKNSGKIVFEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVB3</accession>
    <name>A0A1Y2AVB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_540908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVB3"/>
    <dbReference type="InParanoid" id="A0A1Y2AVB3"/>
    <dbReference type="OrthoDB" id="2751476at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021425">
        <property type="entry name" value="DUF3072"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11272">
        <property type="entry name" value="DUF3072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="351" mass="37630" checksum="DA8FAF8D6975D81D" modified="2017-08-30" version="1">MADPSSLPPLPKDHLDHPENWATGADPATDKQKGFIKVLEDKNPGLVPSDGLDVVNMGKSEASEVIEKLKNGEEVITGDAEKNGKKVMSGDAEKNGEDVKSREEVKNGDVKEHGKEEAAEITTTEAVEPSGDESQKKEDVALEAPSSLDDDKVDKQTSDKKKAVEGDNKDHSDDKTIAVDPPSEEKLEKGQSTLDSALKPTASSSTNESKRPSDHAENGTGDGGEEDRKSKKARVEDAVDDHVVKTPVSGHRKRSSTVSIPVSEMPIQTPSKTTSHVPPTTAEPSTLPGDGEHLDHPENWTTGDEPATEKQKGFIKVLEKQKGVDAQQKVGDLGDLGKSEASEKIEDLKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVF8</accession>
    <name>A0A1Y2AVF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_470318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVF8"/>
    <dbReference type="STRING" id="71784.A0A1Y2AVF8"/>
    <dbReference type="InParanoid" id="A0A1Y2AVF8"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10067" checksum="DD2ACDA0C350FA8D" modified="2017-08-30" version="1" fragment="single">YYNAGGAPGACGDPIQDSDHIVALNQAQYNPPGAGQISLSCGATVAITAVGHNVTVSATIKDMCPGCGEHSLDLTQGLWDLMNQESGGTFDGIFPISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVV5</accession>
    <name>A0A1Y2AVV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">BCR39DRAFT_540439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVV5"/>
    <dbReference type="FunCoup" id="A0A1Y2AVV5">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AVV5"/>
    <dbReference type="InParanoid" id="A0A1Y2AVV5"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000013">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY26689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="395" mass="42661" checksum="029AF4D71AEFCE0D" modified="2017-08-30" version="1">MVAQAPSGKQPLPEMMTSIRFSSSGEVEIVDQLLLPHAVNWLKISTPEEAFDAIKTMKIRGAPAIASLAALSIRSHLSQASSTLPSFTSTKSVKDHLVPICDYLESSRPTAVNLGEAMERIRKLLESESGQSVITPEVLVEKVKVLCLNVFNEDLERCKEMGRIGAEWLWSKRGDGKKNGLKVITVCNTGSLATSGYGTAIGVITSLFETSHLDTAYYAQTTPYHQGSRLTSLELTTLQVPACMICDTMLGSLMQQEDIDAVIVGADRIVANGDTANKIGTYQAAVLAQRHGVPFMVVAPVATVDLSLQTGKQIHIEHRPAIEATLVRGRNVQTGELSVVRITPEGVGEGKEKWQQVYNPSFDVTPAELISCVVTERGVAERVKGKDSIDVASVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVW4</accession>
    <name>A0A1Y2AVW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_542350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000051">
        <property type="protein sequence ID" value="ORY26045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVW4"/>
    <dbReference type="InParanoid" id="A0A1Y2AVW4"/>
    <dbReference type="OrthoDB" id="408973at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265">
        <property type="entry name" value="BLL2707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
        <property type="entry name" value="GLYOXALASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="286" mass="31451" checksum="B5383B12F02998B0" modified="2017-08-30" version="1">MPDSLPTPQLDHIVIHVPYAYLSSPPSWLTELFTITPGGTHADGLTANALVPFSDGTYLELIAFTPEITAEQKRNHMWGGKPYGIIDWALTLPKKDDQGNASQYQILRKRWLDLPVPPKWKSSELRQGGRTKPDGTKLEWLIAFPPERGVTPFWCLDVTARSHRVSSAIDQITHPSGVQGIAEVSLNLPQGGITSEIKPILDAAVPQSEDRVDDYTWSIGTPAPTENGPGKVYAHSARIRITQESIAKDETRLGVTELIFWTRDKGNSSVEATIDGDKVSFGFVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AVX3</accession>
    <name>A0A1Y2AVX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_540424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000045">
        <property type="protein sequence ID" value="ORY26682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AVX3"/>
    <dbReference type="InParanoid" id="A0A1Y2AVX3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="174" mass="19215" checksum="9B740B6B74C04571" modified="2017-08-30" version="1">MSTVSLSFPSGRQSTADSSFSAGHQPFDDVPGCPPFALRTFSPTAGVKDKASISVARSGWTLLLQCRSYMTVQSEGDNHSLVLQETVKTARISRDSTVVQSNWTDPYIVDPSNSTGYYEQQDPTPRLQTALVEAWDAVHNNRPESDIQQRTDYVASLLDTGDLPSFVTLRRPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AW14</accession>
    <name>A0A1Y2AW14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_540947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000047">
        <property type="protein sequence ID" value="ORY26490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AW14"/>
    <dbReference type="FunCoup" id="A0A1Y2AW14">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AW14"/>
    <dbReference type="InParanoid" id="A0A1Y2AW14"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY26490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="448" mass="48718" checksum="EB2CC3E344000CC3" modified="2017-08-30" version="1">MSFLGRPSTSRLVPLASSSRSIHTSAPVLAKGPKKQTLRVALKRTNRFGKGKENLVKPVRTITRTIPKLTFSGASEIPDLSNFIQLHPDTYASRSVGSPTTFPQQSFGRLQTFGLPRKLEKEFAEGGSPASVVRQRTVDLARTLDAARSSSSADKRYMITGGSGTGKSMLLFQAVNYAIDSKWIVLYTPRMDQWIDSSSPYAYSQETKTFHQPVLAAKLLQTTLSSNQKALAGLRLGETLPLEGGQILGPDTDLAEVCKIGSRDERISVPVLEAFFKALGSQTEVPVVWAMDEVHSVFTSSRYRAPDFSVLESYHLSMPLLALDYLTGRKTFSRGIVLAAYSHSTPSLPIPPVLTTALALPSTHATAITPYTPLNPTHLAHASASIQRFQVPFGMSPVEAGGMAEIWQKKGWARPAGDEALMSGLSLSMGNPEVMGKGWRFDFKSMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWA6</accession>
    <name>A0A1Y2AWA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BCR39DRAFT_539880</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="MCFC01000043">
        <property type="protein sequence ID" value="ORY26871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWA6"/>
    <dbReference type="FunCoup" id="A0A1Y2AWA6">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWA6"/>
    <dbReference type="InParanoid" id="A0A1Y2AWA6"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="15">
        <location>
            <begin position="109"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="16">
        <location>
            <begin position="279"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORY26871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="356" mass="37929" checksum="DE08BEBC4D6E7725" modified="2017-08-30" version="1">MSSEPQTPVPQPNGTDLTPSSSLILPPTSEHSQPASSRTNKSSFGAESTMSLLVESLKDRMLFAVPKKGRLMEKTLELLAGADVKYNRAHRLDVALVQNHPIALVFLPAADIPRFVALGSVALGITGQDVIAESTHAEQITELLPLGYGKCSLQVQVPVSGPYQSVEELSGARVATSFEVLAGEFFSKVDEKAGKGKKTRVEYVGGSVEAACALGMADGIVDLVESGDTMRAAGLHAIHTLLTSEAVLITSRAPHPSLTPALAPLVPMLKSRFAGVLAAKRYVYASYNIRREQLPSALKITPGRRAPTVSPLEEDGWVAVSAMVERKAMAKTMDELERAGAEDVLIFAMDNCRVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWC9</accession>
    <name>A0A1Y2AWC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_540714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWC9"/>
    <dbReference type="InParanoid" id="A0A1Y2AWC9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY26600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="152" mass="16095" checksum="D44E7D5FCA6F6EAC" modified="2017-08-30" version="1" fragment="single">MSLRSAARLARPLRSSVAASAASKRAPAITRRYASSESHGSSSDRVWVLGAAAVWIPLGAYLSFSGPEDNHHVSHPKPDAATDQYGNTGVQAMYKDLNHDEPAKKDAPEGSEESTPDSKDEGEEPSAQDVKESLQQAEVSFSSATNGLAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AWH2</accession>
    <name>A0A1Y2AWH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Topoisomerase II-associated protein PAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_253613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000046">
        <property type="protein sequence ID" value="ORY26587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AWH2"/>
    <dbReference type="FunCoup" id="A0A1Y2AWH2">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2AWH2"/>
    <dbReference type="InParanoid" id="A0A1Y2AWH2"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="316"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY26587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="820" mass="88715" checksum="3DD739B2E61C0683" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AX22</accession>
    <name>A0A1Y2AX22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vitamin H transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BCR39DRAFT_249809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000044">
        <property type="protein sequence ID" value="ORY26777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AX22"/>
    <dbReference type="FunCoup" id="A0A1Y2AX22">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2AX22"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="67"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORY26777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="514" mass="56786" checksum="024FE41598010914" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AXM4</accession>
    <name>A0A1Y2AXM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_483622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000039">
        <property type="protein sequence ID" value="ORY27339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AXM4"/>
    <dbReference type="InParanoid" id="A0A1Y2AXM4"/>
    <dbReference type="OrthoDB" id="5538558at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF39">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY27339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="287" mass="32386" checksum="0F630CB7FB590B2E" modified="2017-08-30" version="1">MLSRARTACTRTALSAWTSRRALSQSKRLMSRNDSEAESESKQLEELFAKFRDPTSHYHLPAGTSGPSHEEDHTTSRLPLGLQLPASSSSFSSTNASSSYSSISGTSASSSSSSTAIVESNNSESRDLAYTYFREEGFDLRGVLEWPVAWGDCDMFRHVNNVQYVRWVEHARIRYSESWDDVLPKETLHGLLSGQGMGYILRDVSVRFKAPVTYPDRVIIANKVHSIDQSRARFMMASTIWSLRQRRVVATAESTMVMFDYDSNCRGTMSDEFRIALESRMPKFDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2AZM3</accession>
    <name>A0A1Y2AZM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_588920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000034">
        <property type="protein sequence ID" value="ORY28029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2AZM3"/>
    <dbReference type="InParanoid" id="A0A1Y2AZM3"/>
    <dbReference type="OrthoDB" id="2591812at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="308" mass="34000" checksum="E496E14C3AF30C3D" modified="2017-08-30" version="1">MSATPTTSTPPAFRRRNLGFDPNQSSTSTPTTSFTDLFPSASSTDGSQQSSGGTNVYYLVFLGVLIILLLLAACLAYRAFRIRRRYRTAAQLAIARGQAPPPMNDQYWGLGRFSGWTPDGLDRFGGGTGWLDPNTRGTGGGRWVRVPELWEAEVGSEDEKQHQQNTDMDADGHGDVWQVANPLAVQSLLSIGEPLLTPDEPSAPVHQMGPRPHPPSSFSLAGLAARRRRTSVLPEEPVVPPEPKEQDREFLEGEPVRVALVIQMPLEAEEARRQRNHGEEEDEVGWNDRMELAVWEGIIGAQDHQRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B009</accession>
    <name>A0A1Y2B009_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_536566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000035">
        <property type="protein sequence ID" value="ORY27880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B009"/>
    <dbReference type="InParanoid" id="A0A1Y2B009"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY27880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="517" mass="54623" checksum="2E78B7AFBC04D2AD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0B6</accession>
    <name>A0A1Y2B0B6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BCR39DRAFT_535179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0B6"/>
    <dbReference type="FunCoup" id="A0A1Y2B0B6">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0B6"/>
    <dbReference type="InParanoid" id="A0A1Y2B0B6"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORY28261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="520" mass="58262" checksum="9F765455D02D741B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0C9</accession>
    <name>A0A1Y2B0C9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_535229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="MCFC01000032">
        <property type="protein sequence ID" value="ORY28272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0C9"/>
    <dbReference type="FunCoup" id="A0A1Y2B0C9">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0C9"/>
    <dbReference type="InParanoid" id="A0A1Y2B0C9"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="313" mass="34319" checksum="F611514BBCC764FE" modified="2017-08-30" version="1">MTPPILSSPEEYKKLIDSVDTFLLDCDGVIYHGSVVVDGVRETLSMLRKAGKKLIFVTNNASKSRQMYKATFDKLNIEAYPEEIFGSGYASAVYLSEILKFPKDKKVYVIGEAGLEEELDSVGIAHSGGTDPEDNTFMSKDDFSVIKSDPSVGAVLCGFDIRINYKKLATAFSHLRDNEGCHFILTNQDPTYPTTQKSKDPSKPDIKTIYPGSGAISAPLLFASKRTPLIIGKPNKPMMDAIIAEHHFDVKRALMVGDNLATDIEFGINSGVRTLLVMGGVTKREQVFGDDPSPVKPDFVMESFGQFATLAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B0Y6</accession>
    <name>A0A1Y2B0Y6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_534830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000031">
        <property type="protein sequence ID" value="ORY28473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B0Y6"/>
    <dbReference type="FunCoup" id="A0A1Y2B0Y6">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B0Y6"/>
    <dbReference type="InParanoid" id="A0A1Y2B0Y6"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="101"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY28473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="213" mass="23338" checksum="FDA5C0127AE49A69" modified="2017-08-30" version="1">MSGTESTVTGPSSTQPLRTTKETHPNLPPGLILGPDGKVCKVCNSWQDFAKTKVKKKDGTGTGIAMGMGAFAGMMSGAKNVKSGATSTPTLEEQQVDRRDCPADNTLLGRSTWTFLHTTAAYYPISAPRQTQDNMRALLVSLSLLYPCGPCATDFRENIRQTPPDLSGREGLSRWLCERHNEVNEKLGKERFDCDWKNLDARWKDGPADGRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B122</accession>
    <name>A0A1Y2B122_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_210603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000033">
        <property type="protein sequence ID" value="ORY28187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B122"/>
    <dbReference type="InParanoid" id="A0A1Y2B122"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY28187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="106" mass="11507" checksum="EA867A31463E378E" modified="2017-08-30" version="1">MSLGNDNGSSAAPRWDQVPRFSVSDDRDNTPPSSGNLGSVLGPPAENPERVVKRMRTRRACDGCRSRKIRCQYPNGREAVGSCAHCELHGLACVATKPTVSTLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B1X9</accession>
    <name>A0A1Y2B1X9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BCR39DRAFT_559386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000029">
        <property type="protein sequence ID" value="ORY28822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B1X9"/>
    <dbReference type="InParanoid" id="A0A1Y2B1X9"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORY28822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="192" mass="20966" checksum="385A0A1FF1E2DB25" modified="2017-08-30" version="1">MKGTCSAKKVSEKDPSPCTITLTAIICDGDMYQATFSVEGDPDNGLSVNNRTRRLGRACIEYLENRFDNFGPFLETYDNLIGDKANGVPQPGCIKCTIRPPGSVETGEQTGSEDEAEATVVTETGTVFGRLHMNEKGTELTLQIWCPEDNNVRSCLPRDKGKSLSQVVDAIVASWRSLRDTWRQNAADASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B2C0</accession>
    <name>A0A1Y2B2C0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydantoinase B/oxoprolinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BCR39DRAFT_533289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000028">
        <property type="protein sequence ID" value="ORY28953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B2C0"/>
    <dbReference type="InParanoid" id="A0A1Y2B2C0"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="243"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="6">
        <location>
            <begin position="555"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="743"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORY28953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1304" mass="140503" checksum="FE4CD26EA3E4F2E8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3E4</accession>
    <name>A0A1Y2B3E4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_593962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3E4"/>
    <dbReference type="FunCoup" id="A0A1Y2B3E4">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3E4"/>
    <dbReference type="InParanoid" id="A0A1Y2B3E4"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY29353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="258" mass="27263" checksum="45231132A3452ED6" modified="2017-08-30" version="1">MASEEAPVKAVQVKLVLLGEAAVGKSSLVLRFCSNDFNENTSPTIGAAFLTQKCRLENRIVKFEIWDTAGQERFHSLAPMYYRNAAAAVVVYDITKAASLEKAKAWVKELQRQANPNIVIALVGNKLDLVSDGPAKSVDEPAEATTDAEGDDSTPPPPSTTAQPSSSDSDDLRQVSTAEAETYAKESSLLFFEASAKTGANVSELFTEIAKTIPMESLAPKPAQGAAAAGGRGGRQEQGRGENVQLGEGQQAKKGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B3S4</accession>
    <name>A0A1Y2B3S4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_532573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000026">
        <property type="protein sequence ID" value="ORY29376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B3S4"/>
    <dbReference type="FunCoup" id="A0A1Y2B3S4">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B3S4"/>
    <dbReference type="InParanoid" id="A0A1Y2B3S4"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY29376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="460" mass="50179" checksum="607163ADBD64DAFC" modified="2017-08-30" version="1">MGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPRYQVTVIDAPGHRDFIKNMITGTSQADCAILIIASGNGEFEAGISKDGQTREHALLAFTLGVRQMIVACNKMDTCKWSEDRFNEIVKEASAFLKKVGYNPKGIAFVPISGWHGDNMLEESTNMSWYKGWSKETKAGTVKGKTLLDAIDAIEPPARPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVSFAPSNVTTEVKSVEMHHEQVSEGMPGDNVGFNVKNVSIKDIRRGNVCSDSKNDPAKEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELIEKIDRRTGKVMEASPKFVKSGDACIVKLVSQKPICVETYAEYPPLGRFAVRDMRQTVAVGVIKSVDKSDKAGGKVTKAAEKATKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B472</accession>
    <name>A0A1Y2B472_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_531222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000024">
        <property type="protein sequence ID" value="ORY29621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B472"/>
    <dbReference type="FunCoup" id="A0A1Y2B472">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B472"/>
    <dbReference type="InParanoid" id="A0A1Y2B472"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY29621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="127" mass="14887" checksum="55149E3318D93C37" modified="2017-08-30" version="1">MSSSNSKIRAFELQSKSKNDLLEQLKELKTELASLRVQKIAGGSASKLTKINTVRKSIARVLTVINQKQRQNLREFYKKSKYLPLDLRYKKTRAIRRRLTHKESHAITEREHKKQIHFPARKYALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B4T9</accession>
    <name>A0A1Y2B4T9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_588407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000027">
        <property type="protein sequence ID" value="ORY29105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B4T9"/>
    <dbReference type="InParanoid" id="A0A1Y2B4T9"/>
    <dbReference type="OrthoDB" id="2564813at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY29105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="210" mass="22435" checksum="F55F142746C36913" modified="2017-08-30" version="1">MPYVDPSSNILSSTPIIKRTSSSSSSSPPFSLSLISTSRPSSPSMVIDTVPRPYPTRIPSHDLTPRPSRTMTVSSHQSSIDLSSPNSNDVEIDTLADNLSSTSLSQSNTSSSSPTPPLSDYTDLDTSPSASSVSIRSLASTEEDTSREGAVARYRAGLYNYTHELYIQAKLASAFAQKKRNAPSPSQFGATQSGMERMAAKKALARRLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B5Z0</accession>
    <name>A0A1Y2B5Z0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase of plants and bacteria-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_588032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B5Z0"/>
    <dbReference type="STRING" id="71784.A0A1Y2B5Z0"/>
    <dbReference type="InParanoid" id="A0A1Y2B5Z0"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY30248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="386" mass="42620" checksum="64196316F8E750FD" modified="2017-08-30" version="1">MPNLQHFFRNLSIAHPPPAPPSQSNPPSSESSRPSSSDPITTYFLGTSSSSSSPTYAQPPLAPIPSTNIAPIAPSSLIFSLTHPPPATSEQTSFFFTALPDPIGFLYHSAQLIRDHLVIDPQARWRHQLIELKLVDEDGLAWTSDGRMSVSLRWMSNILDETKDGRKDMRAAAKEIKGVLLHELTHVIQHDGSGTCPIWLIESLADHIRLQAHLDPPHWRKAGVGKRDKGWEEGYDAGARFLTWLVGSDSELESTGQLQVGVEEVDEGEGQGGYEIQKNEIGFGVGSGVEIEPTKTQGAKTPMTTKYPLPSTGEPGMGQRQGGGREKSTNTTSGSKAKPRRRGPFPEFVKLLDARLEYNKYQESWWVEMTGADLSTLWKEYLDYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B673</accession>
    <name>A0A1Y2B673_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_530351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000022">
        <property type="protein sequence ID" value="ORY29967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B673"/>
    <dbReference type="STRING" id="71784.A0A1Y2B673"/>
    <dbReference type="InParanoid" id="A0A1Y2B673"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY29967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="492" mass="54283" checksum="0448ADBCFBB93260" modified="2017-08-30" version="1">MGRKKIDIRPLVDERNRNVTFLKRKAGLMKKAWELSVLCAADVSILIFSSSGKPYEFSSHDLDEELDRYLEYEGSIERRRGEEFAAMAAAGEDDDDDEDEKPMKVGPGTTSTAPTKSLKGKESFKPRMTSRADLVRARRRTETKDKDKGKRRREVSEKRSFVEDTFSQSDESESESTPEPPRPIRKTSHGEVVGVSAFERPRSPARTHSADLTHLHYALNSHALPGPSHNPHESYTNPSTQYRLPPNATAFRVATLSNQHYPPPPQQPQHQHQQQQQYYSGYPPASTPSHQQQPPPQPQQLQQPQQQQAYYPTLPSGMQWDPALVARYAEFQLQQNHQRQQRALLERQRQQLAELGIPVEDKTLLDQLFGGMSGTPSGSGGPSTGIGGSSGGGGNDSAQTEQGFDWPNVNRSNQPLQGLQGYGMLQGLGSSDGGQVGGPGNDDENLAWAFGEDTSGAGGGTAPLPSPASEGSKARKRDRTAESYRTDKKVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6S6</accession>
    <name>A0A1Y2B6S6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BCR39DRAFT_452925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6S6"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6S6"/>
    <dbReference type="InParanoid" id="A0A1Y2B6S6"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORY30548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="924" mass="98358" checksum="65AD6C68B79E6BA1" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B6V2</accession>
    <name>A0A1Y2B6V2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BCR39DRAFT_109548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000019">
        <property type="protein sequence ID" value="ORY30561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2B6V2"/>
    <dbReference type="STRING" id="71784.A0A1Y2B6V2"/>
    <dbReference type="InParanoid" id="A0A1Y2B6V2"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010993732" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORY30561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="216" mass="21615" checksum="300799A0B121C5A8" modified="2017-08-30" version="1">MFALTAILSLLLLLQPSLAKVYCTGPTASTVGVGGQVLTVTWADDGSSPTVAEIGQSSIDLYVGSVDKQTALQNLAASVDVSKASSVSATVNPTIGESGNYYFVKFTSLSLKDSTNPQYNYEAFSAKFQMSEMSGQFNATVLSEIDASNSTTTAATSGAAAVAAVGASSAAHASSTSSSHASVSTSSKTTTSGALSTVAVPGLMAVVLGVAGILFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B700</accession>
    <name>A0A1Y2B700_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BCR39DRAFT_530225</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="MCFC01000021">
        <property type="protein sequence ID" value="ORY30247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B700"/>
    <dbReference type="InParanoid" id="A0A1Y2B700"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000205">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="19">
        <location>
            <begin position="86"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="20">
        <location>
            <begin position="206"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="21">
        <location>
            <begin position="795"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="18">
        <location>
            <begin position="1123"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORY30247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1595" mass="177124" checksum="D1DF2D3381718A22" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B942</accession>
    <name>A0A1Y2B942_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_526363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000015">
        <property type="protein sequence ID" value="ORY31381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2B942"/>
    <dbReference type="InParanoid" id="A0A1Y2B942"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_Nup160_C"/>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="62"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="7">
        <location>
            <begin position="941"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="6">
        <location>
            <begin position="1213"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY31381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1457" mass="160816" checksum="157281F573E56B93" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2B9Y1</accession>
    <name>A0A1Y2B9Y1_9TREE</name>
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            <fullName evidence="4">SCA7, zinc-binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_87918</name>
    </gene>
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        <name type="scientific">Naematelia encephala</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="247"/>
        </location>
    </feature>
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    </feature>
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        </source>
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            <dbReference type="EMBL" id="ORY31649.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAQ6</accession>
    <name>A0A1Y2BAQ6_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_524603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="71784.A0A1Y2BAQ6"/>
    <dbReference type="InParanoid" id="A0A1Y2BAQ6"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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            <end position="470"/>
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            <begin position="205"/>
            <end position="214"/>
        </location>
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            <end position="234"/>
        </location>
    </feature>
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        </location>
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            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="571" mass="61154" checksum="F3FA8DE0E3A3E304" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAS7</accession>
    <name>A0A1Y2BAS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BCR39DRAFT_587362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naematelia</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000013">
        <property type="protein sequence ID" value="ORY31854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAS7"/>
    <dbReference type="STRING" id="71784.A0A1Y2BAS7"/>
    <dbReference type="InParanoid" id="A0A1Y2BAS7"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORY31854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="481" mass="50374" checksum="BE0AD6930B249C6F" modified="2017-08-30" version="1">MSNIFFPGGSRNTSTTSGSGDGIDETQFALMNDSQDIQRRDKQDKANDKEDDDSHSSVSDTTAISTSVALSTSPAPAFTTTHDSVTSSPPVQEITQTSTATTTSASQSDSSSTPELSFTAGQDLTFSSPAVRSTSTSSPISEITDPNSSSQSSSPIDQNSAPSTPNLTVQSLATAPSTPSVTPSGPPLTSPATFPVSDAIPSATSGPATVAPATILVTSSGPFSADPSTSSTSSVTVGSAADDSSPNISILNTKNHLFPLAVAGIALGGLFVMIALGVLIVRLFGWNKRRRDRLIPSFLQVETMSNQHTLDEDKETQRPMIVRGEAEWDAIASTRTRNSFPDYIAYSPPVAVAVTKATARIPAATTISPARDQQRVLVTGPGDHNEAYDGAFFPTSEPLEPSSQEYIRGEASPTRSSSDGMGSPVPSFHTGRTLYPTNDTLVSSSSRRDESETTERFGLYGYPNSLQSRIVLARASSTNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BAT5</accession>
    <name>A0A1Y2BAT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_524761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000012">
        <property type="protein sequence ID" value="ORY31952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BAT5"/>
    <dbReference type="FunCoup" id="A0A1Y2BAT5">
        <property type="interactions" value="764"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BAT5"/>
    <dbReference type="InParanoid" id="A0A1Y2BAT5"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY31952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="278" mass="30623" checksum="30F87EC4D651E79C" modified="2017-08-30" version="1">MNQHPAMWGHPMTPHQAFNAHTAFPLATPNPMRNQHASSPVSHTQQPLVTGTSVLGLKYKDGVMLAADNLASYGSLARFRDIQRLHPLGNHTCLAVSGDMSDYQYLKKELDGLLREEEALSLSDSHPALHPSQIYAFLANLFYARRSKVNPIWNAILVGGWDATKEESFLGYVDLLGTTYSSPTLATGFGSHIAQPLLREAFEKKAGIDGKGELLTAEEAEALLNECMKVLFYRDARSLNKYQIATVTKEGVQISESKSAETQWGFAEALRGYGAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BB84</accession>
    <name>A0A1Y2BB84_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_564341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BB84">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BB84"/>
    <dbReference type="InParanoid" id="A0A1Y2BB84"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="3">
        <location>
            <begin position="953"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY32079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1395" mass="155391" checksum="A71DF9EAA8201899" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBQ8</accession>
    <name>A0A1Y2BBQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BCR39DRAFT_523632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000010">
        <property type="protein sequence ID" value="ORY32259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBQ8"/>
    <dbReference type="FunCoup" id="A0A1Y2BBQ8">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BBQ8"/>
    <dbReference type="InParanoid" id="A0A1Y2BBQ8"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORY32259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="551" mass="60592" checksum="4A3556F17F621398" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BBZ0</accession>
    <name>A0A1Y2BBZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_525879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000014">
        <property type="protein sequence ID" value="ORY31605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BBZ0"/>
    <dbReference type="InParanoid" id="A0A1Y2BBZ0"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY31605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="277" mass="31079" checksum="DD0CADB789125DE2" modified="2017-08-30" version="1">MSSHQYTKSVETDNSFSSYQPTAVNHTPRLESANYTGPVFLNPPPDYSSIDTPEFRLQSAVDTAISKIPDATAQRVYTLTKSDEYMGFRFPIGYARYSTTHKTSCFYAHIGADEHALMWTFTVSAYLRDREVNNFAGETLTVFLEPGEVTFGQRLKDQIPLGLGWSISRLGQCISNGWIATWKERGRPFTTRPSIVSHNIRYPDESDVMVSLDLTLGFWRPYDEPEPSLDPFTQAEASQGLVSQPEESQAGPSRESLSRRGGYGGLVRTKSRMCRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BD97</accession>
    <name>A0A1Y2BD97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_557372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BD97"/>
    <dbReference type="InParanoid" id="A0A1Y2BD97"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY32809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="171" mass="18391" checksum="1E70B5EC1E6D356F" modified="2017-08-30" version="1">MSRSEREVTVRVPSGEPLNTSPRYNRLIWGCFQHLANHGRTKSLAPSATTGAVPSGQEITSQTQPSSPMKIDSAIGESCVDNSHSNHSNTADTSPGMGELLDFDVCKGKDGTWHLAWGYPTSFTARGRVQNDDGDDDDDGDGDDDDDVTLAFETLEITVEPRSESMVSAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDA4</accession>
    <name>A0A1Y2BDA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BCR39DRAFT_521822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">68-887.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDA4"/>
    <dbReference type="FunCoup" id="A0A1Y2BDA4">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BDA4"/>
    <dbReference type="InParanoid" id="A0A1Y2BDA4"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORY32819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="210" mass="23511" checksum="5A8B21645C0A5FF2" modified="2017-08-30" version="1">MSIMEYNGGSVVAMVGKDCVAIATDMRLGQQSIGVAHNFEKVFPINDKLYYGLPGLASDVYSLREHLRFRVNMYRMKEEREITPKTFTHLLSSTLYEKRFGPWFLEPVVAGLPAPTEMEPHPKPFISTMDTIGCITTPKDFAVAGTATDKLYGVAEGLWEPDLEPEDLFETISQTLLNAVDRDALSGWGAVVHVITHDKVITRTLRSRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BDH8</accession>
    <name>A0A1Y2BDH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BCR39DRAFT_524202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">68-887.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000011">
        <property type="protein sequence ID" value="ORY32115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BDH8"/>
    <dbReference type="FunCoup" id="A0A1Y2BDH8">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y2BDH8"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF91">
        <property type="entry name" value="GENERAL ALPHA-GLUCOSIDE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORY32115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="754" mass="81468" checksum="F6D0759DF566A635" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE30</accession>
    <name>A0A1Y2BE30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_521152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE30"/>
    <dbReference type="InParanoid" id="A0A1Y2BE30"/>
    <dbReference type="OrthoDB" id="10609711at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013050568" evidence="1">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="240" mass="25881" checksum="22076F01BCF1D064" modified="2017-08-30" version="1">MRPSSLGLILPSLFVLLFLKVSALPSPLTTTTDDVTLDNTVLATTIAGLSASISQGTYVIRSTVTNKFMSFHYNNVTWEYDLFVNDTVPYSWTIGQVNFDDDDGFVNGQGTVVASANKRTIEGGIDQCVYAQWNTPAQADINVATKTCALSIPRAKTLWLLVPSATKPCSSSVPDGASTCRGVFSIVACDHLLDAPARAIDASAPPELVTEEGTRWGSGMVLWKNQDQADSLWEVWQAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BE98</accession>
    <name>A0A1Y2BE98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BCR39DRAFT_521480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000007">
        <property type="protein sequence ID" value="ORY33151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BE98"/>
    <dbReference type="STRING" id="71784.A0A1Y2BE98"/>
    <dbReference type="InParanoid" id="A0A1Y2BE98"/>
    <dbReference type="OrthoDB" id="3219336at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORY33151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="603" mass="67353" checksum="ED8FC8561EDBB974" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEB2</accession>
    <name>A0A1Y2BEB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BCR39DRAFT_351775</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">68-887.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="MCFC01000008">
        <property type="protein sequence ID" value="ORY32817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y2BEB2">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="71784.A0A1Y2BEB2"/>
    <dbReference type="InParanoid" id="A0A1Y2BEB2"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000064">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1076"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1119"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1155"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1184"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1227"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="216"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="310"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="1005"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="861"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="862"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="863"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="953"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="959"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="979"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="982"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="983"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="983"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ORY32817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="1328" mass="148414" checksum="ABC0D0824ED18604" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BEF7</accession>
    <name>A0A1Y2BEF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_330670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="141"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="569"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="676" mass="72221" checksum="CE2D57BE3D92FF0E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y2BF11_9TREE</name>
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        <recommendedName>
            <fullName evidence="1">CFA20 domain-containing protein</fullName>
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        <name evidence="2" type="ORF">BCR39DRAFT_519928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
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        <lineage>
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            <taxon>Naematelia</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
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                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="270" mass="30334" checksum="816C5A1E6380510A" modified="2017-08-30" version="1">MSLLAGTIQPPLMTLLSSTSQPSLSPLFRLHVDPKRPNGSIIRTIDDTSEDPELVPRHYERGDIVHRVIHIQSPDNRSTYIQAGCLKTQYDRYNKQDIQPLGIELGWVHLQVKRLGRREMSFEVGIVDARGREGVVRCSSFQQTPKVHAERSPPLIHLPLALPQQGPTTLTQWLDISLDLAALLPLFQSLPRRLPSSNGSSDEEDNVRAQKRRKMVELPSGRFASISCIRVYANCRVRRIWVTAEGQKTMDGMGRALKDEWGLYAAASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BF34</accession>
    <name>A0A1Y2BF34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_299181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000006">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="71784.A0A1Y2BF34"/>
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    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="406" mass="46205" checksum="C8213CF9788838B8" modified="2017-08-30" version="1">MSLNTVVNNLVRAAAGIPADISDDDLDRHVASLLAQEAKQRESKWSEMGLSAFLDRESNDAALPRPNKRFLASVIRNVDGHNAALLREQAQAARNARLGRGESSRTGASRLFGGALQGMRRESGGDRDRRREEDRRNRHDDREDKARSRRYHDERDASPYRRDERDRDDRRRSGHYDQESEPRRREERHQHSRRHGDDEDNDGGGTRQHHSSKQKSTTSKREPDSSPRPPKKRTPSPRPSSRPAPEDSPPPPPRSPISKMDKYFSTSYDPRLDLGEIPKEGMIAAVGWDNMLAVLKERGQKRRHMSPGLSDDLPSVPKGVLIRSPSPDPIVRKKKEERRKRRGDSDSDDERERAKRKEKRRKDKEREKHLSTPAKSNGSTAGGAGALLEGYEYVRKGGVREWDVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFU3</accession>
    <name>A0A1Y2BFU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BCR39DRAFT_503785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Naematelia encephala</name>
        <dbReference type="NCBI Taxonomy" id="71784"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Naemateliaceae</taxon>
            <taxon>Naematelia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Pervasive Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Ramamoorthy G.K."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J.K."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">68-887.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MCFC01000005">
        <property type="protein sequence ID" value="ORY33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y2BFU3"/>
    <dbReference type="InParanoid" id="A0A1Y2BFU3"/>
    <dbReference type="Proteomes" id="UP000193986">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORY33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193986"/>
        </source>
    </evidence>
    <sequence length="458" mass="50431" checksum="5180CA43C6D92054" modified="2017-08-30" version="1">MSCYYPPSTFHPDTCGKQIGSRSSSPESVTRLSQTISHGTHPTKRPLPGYGRLVSVFSWEDPYSRGNEISNPENVDSQVTRSNEDVDPQVTSSNEDVDPQVTSSNEDVDPQVTNSNPTSKATTPYTTPGSVLPEVSGAKSTQPLLSTESLIYHSTIQRSACSGNSTRLTVRDRRKQIRGITKGITKTVCAATSKSSRMKLHALPPWVQGSWKDEDSRAHIRFAVLDGDLFRDPGWDPYVSQFSPKDLPYYERALTMALVNLQTRWTVAFEKIPNKTDFTHVRYSMESVISSMVDYNPGPVGRISVKGKGLASCSGHLRRYPVLDLEISVDRRIRPKDLDDFPTFSPATAEFTATPRSDRSKRKRRNLEESGLLDPSFTMGSSGNQMSARNKEFYPDMEGKGGVCDGQTTSVNTTVNLATASTSPTSMEAYNNLARDREADALQAPSGRGEMSIFSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y2BFZ5</accession>
    <name>A0A1Y2BFZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Armadillo